3,289 results match your criteria Seborrheic Dermatitis


Whole Fruits and Fruit Fiber Emerging Health Effects.

Authors:
Mark L Dreher

Nutrients 2018 Nov 28;10(12). Epub 2018 Nov 28.

Nutrition Science Solutions, LLC, Wimberley, 78676 TX, USA.

Less than 10% of most Western populations consume adequate levels of whole fruits and dietary fiber with typical intake being about half of the recommended levels. Evidence of the beneficial health effects of consuming adequate levels of whole fruits has been steadily growing, especially regarding their bioactive fiber prebiotic effects and role in improved weight control, wellness and healthy aging. The primary aim of this narrative review article is to examine the increasing number of health benefits which are associated with the adequate intake of whole fruits, especially fruit fiber, throughout the human lifecycle. Read More

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http://www.mdpi.com/2072-6643/10/12/1833
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http://dx.doi.org/10.3390/nu10121833DOI Listing
November 2018
7 Reads

Kava-induced acute cutaneous toxicity: An increasingly recognized characteristic clinicohistologic pattern.

JAAD Case Rep 2018 Nov 10;4(10):1037-1038. Epub 2018 Nov 10.

Department of Medicine, Division of Dermatology, Montefiore Medical Center, Bronx.

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http://dx.doi.org/10.1016/j.jdcr.2018.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232697PMC
November 2018

Recurrent Vulvar Ulcers and "Cradle Cap" in a 2-Year-Old.

J Pediatr 2018 Oct 12. Epub 2018 Oct 12.

Department of Dermatology University of Virginia Health System Charlottesville, Virginia.

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http://dx.doi.org/10.1016/j.jpeds.2018.09.043DOI Listing
October 2018
3 Reads

Increased IL-17-expressing γδ T cells in seborrhoeic dermatitis-like lesions of the Mpzl3 knockout mice.

Exp Dermatol 2018 Dec;27(12):1408-1411

Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida.

Seborrhoeic Dermatitis (SD) is a common inflammatory skin disorder, but its molecular pathogenesis remains elusive. Previously, we have established the Mpzl3 knockout (-/-) mice as a model for SD. In this study, we focused on early phases of skin inflammation and determined the cytokine profiles and identified immune cell types in the lesional skin in the Mpzl3 -/- mice. Read More

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http://doi.wiley.com/10.1111/exd.13798
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http://dx.doi.org/10.1111/exd.13798DOI Listing
December 2018
1 Read

A patient with delusional infestation by proxy: Issues for vulnerable adults.

Dermatol Ther 2018 Nov 8;31(6):e12724. Epub 2018 Oct 8.

Royal London Hospital, Barts Health Trust, London, United Kingdom.

A 57-year-old Caucasian female presented to our clinic with her 23-year-old son, who was profoundly autistic. Our patient was convinced that her son had an infestation with fibers and believed that he had developed the condition as a young child. She described the symptoms of the infestation in her son's skin on his behalf, as he was not able to communicate. Read More

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http://doi.wiley.com/10.1111/dth.12724
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http://dx.doi.org/10.1111/dth.12724DOI Listing
November 2018
4 Reads

Improvement of severe facial seborrheic dermatitis following low-dose isotretinoin therapy.

G Ital Dermatol Venereol 2018 Sep 20. Epub 2018 Sep 20.

Dermatology Department, University of Pisa, Pisa, Italy.

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https://www.minervamedica.it/index2.php?show=R23Y9999N00A180
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http://dx.doi.org/10.23736/S0392-0488.18.06029-7DOI Listing
September 2018
6 Reads

Diagnosing Pemphigus Foliaceus: A Rare Blistering Disease Masquerading as a Common Dermatologic Disorder.

Mil Med 2018 Sep 12. Epub 2018 Sep 12.

Department of Dermatology, San Antonio Military Health System, 3551 Roger Brooke Drive, San Antonio, TX.

Pemphigus foliaceus (PF) is an autoimmune dermatologic disease that typically presents with painful, superficial blisters that evolve into scaling erosions in a seborrheic distribution. This case study intends to demonstrate that due to the relative scarcity of the disease and its distribution on the body, PF can easily be misdiagnosed. We present a 43-year-old African American male that presented to the dermatology clinic with an 18-month history of non-pruritic, violaceous, scaling patches and plaques most prominent on the malar cheeks, upper chest and upper back. Read More

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http://dx.doi.org/10.1093/milmed/usy224DOI Listing
September 2018

Topical Selenium Sulfide for the Treatment of Hyperkeratosis.

Dermatol Ther (Heidelb) 2018 Dec 10;8(4):639-646. Epub 2018 Sep 10.

University of California San Diego Hyperbaric Medicine and Wound Healing Center, Encinitas, CA, USA.

Hyperkeratosis presents as thickened skin. It can be congenital or acquired. Typically, it affects the palms and soles; the distribution of epidermal involvement is either diffuse, focal, or punctate. Read More

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http://link.springer.com/10.1007/s13555-018-0259-9
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http://dx.doi.org/10.1007/s13555-018-0259-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261123PMC
December 2018
6 Reads

Scalp Itch: A Systematic Review.

Skin Appendage Disord 2018 Aug 29;4(3):187-199. Epub 2017 Nov 29.

Fredric Brandt Endowed Professor of Dermatology, University of Miami, Miami, FL, USA.

Scalp itch is a frequent complaint in the dermatological setting. It is common for the dermatologist to encounter patients with no evident cause of scalp pruritus, making it a distressing situation for both the clinician and the patient. The aim of this paper is to propose a systematic approach to scalp itch, which classifies scalp pruritus into two types: (1) with or (2) without dermatological lesions, and presence or absence of hair loss. Read More

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http://dx.doi.org/10.1159/000484354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120392PMC
August 2018
6 Reads

The role of nutrition in inflammatory pilosebaceous disorders: Implication of the skin-gut axis.

Australas J Dermatol 2018 Sep 3. Epub 2018 Sep 3.

Dermatology Division, Department of Medicine, University of Arizona, Tucson, Arizona, USA.

Nutrition plays a critical role in the manifestation and management of inflammatory pilosebaceous disorders. There is rich potential for insight into the impact of dietary effects on the pathophysiology of inflammatory pilosebaceous disorders including acne vulgaris, hidradenitis suppurativa, rosacea, and the closely related seborrhoeic dermatitis. Acne vulgaris and hidradenitis suppurativa are thought to have similar diet-modulating pathogenic pathways. Read More

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http://doi.wiley.com/10.1111/ajd.12909
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http://dx.doi.org/10.1111/ajd.12909DOI Listing
September 2018
13 Reads

Comorbid conditions in lichen planopilaris: A retrospective data analysis of 334 patients.

Int J Womens Dermatol 2018 Sep 7;4(3):180-184. Epub 2018 Jun 7.

Department of Dermatology and Dermatopathology, Cleveland Clinic Foundation, Cleveland, Ohio.

Background: Lichen planopilaris (LPP) is a rare, cicatricial, lymphocyte-mediated alopecia that is thought to have an autoimmune pathogenesis and possibly related to other autoimmune diseases. However, data are limited and studies that examine comorbid conditions are lacking.

Objectives: We sought to determine the prevalence of systemic comorbid conditions, nutritional deficiencies, psychological problems, and skin cancers in patients with LPP. Read More

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http://dx.doi.org/10.1016/j.ijwd.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116820PMC
September 2018
2 Reads

Expression of inflammatory and fibrogenetic markers in acne hypertrophic scar formation: focusing on role of TGF-β and IGF-1R.

Arch Dermatol Res 2018 Oct 29;310(8):665-673. Epub 2018 Aug 29.

Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.

Acne vulgaris is a universal skin disease and it may leave a scar when the original skin lesion disappears. These scars can cause cosmetic problems and psychological burden, leading to poor quality of life of patients. Acne scars are classified into atrophic scars and hypertrophic scars. Read More

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http://link.springer.com/10.1007/s00403-018-1856-2
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http://dx.doi.org/10.1007/s00403-018-1856-2DOI Listing
October 2018
12 Reads

A perspective study of cutaneous manifestations in primary psychiatric disorders in a tertiary care hospital.

Indian J Psychiatry 2018 Apr-Jun;60(2):213-216

Department of Psychiatry, Justice KS Hegde Charitable Hospital, Deralakatte, Mangalore, Karnataka, India.

Background: Cutaneous disorders are frequently seen in psychiatric patients. This may be attributed to the common ectodermal origin of skin and neurons. There is a paucity of data on cutaneous comorbidity in primary psychiatric disorders. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_156_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102963PMC
September 2018
1 Read

Wound myiasis: the role of entodermoscopy.

An Bras Dermatol 2018 Sep-Oct;93(5):746-748

Dermatology Unit, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil.

Although wound or traumatic myiasis is common in tropical countries, only recently cases associated with underlying dermatoses, such as seborrheic dermatitis and psoriasis, have been reported. We describe a patient with seborrheic dermatitis and an ulcerated lesion on the scalp, in which the dermatological examination with the aid of dermoscopy allowed the identification of larvae (maggots) compatible with infestation by Cochliomyia hominivorax. Treatment was performed with oral and topical ivermectin, followed by manual extraction of the larvae. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20188043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106665PMC
October 2018
15 Reads

Fogo selvagem: endemic pemphigus foliaceus.

An Bras Dermatol 2018 Sep-Oct;93(5):638-650

Dermatology Service, Hospital Maria Aparecida Pedrossian, Universidade Federal de Mato Grosso do Sul, Campo Grande (MS), Brazil.

Fogo selvagem or endemic pemphigus foliaceus is an autoimmune acantholytic anti-cadherin bullous disease that primarily affects seborrheic areas, which might disseminate. Brazil has the world's largest number of patients, mainly in the Central-West region, but the disease has also been reported in other South American countries. It affects young people and adults who have been exposed to rural areas, with occurrence of familial cases. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20188235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106655PMC
October 2018
10 Reads

Correlating CD4 count with mucocutaneous manifestations in HIV-positive patients: A prospective study.

Indian J Sex Transm Dis AIDS 2017 Jul-Dec;38(2):128-135

Department of Community Medicine, Government Villupuram Medical College and Hospital, Villupuram, Tamil Nadu, India.

Background: Mucocutaneous findings may be the presenting symptoms in HIV-afflicted individuals. A multitude of mucocutaneous diseases also occurs during the course of the ailment, with some conditions being classed as disease defining. They include infectious diseases and noninfective inflammatory and neoplastic dermatoses. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_130_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085934PMC
August 2018
7 Reads

Inflammatory dermatoses in human immunodeficiency virus.

Indian J Sex Transm Dis AIDS 2017 Jul-Dec;38(2):113-120

Department of Dermatology and S.T.D., Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

Various inflammatory dermatoses have been described in association with human immunodeficiency virus (HIV) infection. These either present in the usual way or in varied atypical presentations. This article gives a brief review about the etiopathogenesis and clinical presentation of the common inflammatory dermatoses associated with HIV such as psoriasis, reactive arthritis, seborrheic dermatitis, eosinophilic folliculitis, pruritic papular eruption, photosensitivity disorders prurigo nodularis, atopic dermatitis, and ichthyosis. Read More

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http://www.ijstd.org/text.asp?2017/38/2/113/216986
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http://dx.doi.org/10.4103/ijstd.IJSTD_22_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085932PMC
August 2018
8 Reads

JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin.

Nat Commun 2018 08 24;9(1):3425. Epub 2018 Aug 24.

Department of Dermatology and Allergic Diseases, Ulm University, Ulm, 89081, Germany.

Transcription factors ensure skin homeostasis via tight regulation of distinct resident stem cells. Here we report that JunB, a member of the AP-1 transcription factor family, regulates epidermal stem cells and sebaceous glands through balancing proliferation and differentiation of progenitors and by suppressing lineage infidelity. JunB deficiency in basal progenitors results in a dermatitis-like syndrome resembling seborrheic dermatitis harboring structurally and functionally impaired sebaceous glands with a globally altered lipid profile. Read More

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http://www.nature.com/articles/s41467-018-05726-z
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http://dx.doi.org/10.1038/s41467-018-05726-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109099PMC
August 2018
4 Reads

Parkinson's disease pathogenesis, evolution and alternative pathways: A review.

Rev Neurol (Paris) 2018 Dec 18;174(10):699-704. Epub 2018 Aug 18.

Department of Neurosurgery, University of Athens, School of Medicine, Evangelismos Hospital, Ipsilantou 45-47, 10676 Athens, Greece.

Sporadic Parkinson's disease (PD) is one of the most common neurodegenerative diseases of the elderly. In the scientific literature, surveys aiming to investigate the potential diagnostic biomarkers for PD have focused on skin and intestinal tissue biopsies, whereas more recent studies have reported an association between PD and skin disorders, such as seborrheic dermatitis and rosacea. In addition, a connection between PD and Crohn's disease has been established. Read More

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http://dx.doi.org/10.1016/j.neurol.2017.12.003DOI Listing
December 2018

Association between Diet and Seborrheic Dermatitis: A Cross-Sectional Study.

J Invest Dermatol 2018 Aug 18. Epub 2018 Aug 18.

Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands. Electronic address:

Current treatments for seborrheic dermatitis provide only temporary relief. Therefore, identifying modifiable lifestyle factors may help reduce disease burden. The objective of this study was to determine whether specific dietary patterns or total antioxidant capacity are associated with seborrheic dermatitis. Read More

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http://dx.doi.org/10.1016/j.jid.2018.07.027DOI Listing
August 2018
1 Read

Progressive Facial Papules in an African-American Patient: An Atypical Presentation of Seborrheic Dermatitis.

J Clin Aesthet Dermatol 2018 Jul 1;11(7):44-45. Epub 2018 Jul 1.

Dr. Friedmann is with the Westlake Dermatology Clinical Research Center at Westlake Dermatology & Cosmetic Surgery in Austin, Texas.

This case report highlights a unique variant of seborrheic dermatitis (SD) in a 30-year-old African-American woman with progressive facial papules. Four weeks of uninterrupted mild potency topical corticosteroid therapy produced marked improvement of signs and symptoms of biopsy-confirmed SD. SD mimicking cutaneous sarcoidosis is a unique treatment-responsive variant of SD that may be more likely to be encountered in African-American patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057738PMC
July 2018
2 Reads

Topical Application of 5-Fluorouracil Associated with Distant Seborrheic Dermatitis-like Eruption: Case Report and Review of Seborrheic Dermatitis Cutaneous Reactions after Systemic or Topical Treatment with 5-Fluorouracil.

Dermatol Ther (Heidelb) 2018 Sep 26;8(3):495-501. Epub 2018 Jul 26.

Department of Dermatology, University of California San Diego, La Jolla, CA, USA.

Introduction: 5-Fluorouracil is a fluoropyrimidine antineoplastic medication that is used to topically treat actinic keratoses. Although local adverse effects to the drug are common and anticipated, distant skin reactions are rare and unexpected. In this case report, we describe a patient who developed seborrheic dermatitis-like eruption at a distant site after topical application of 5-fluorouracil to his arms. Read More

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http://dx.doi.org/10.1007/s13555-018-0253-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109033PMC
September 2018
2 Reads

[Iatrogenic Cushing's syndrome in a infant due to prolonged use of topical corticosteroids. Case report].

Rev Chil Pediatr 2018 Jun;89(3):368-372

Unidad de Endocrinología Pediátrica, Servicio de Pediatría, Hospital Dr. Sótero Del Río, Chile.

Introduction: Cushing's syndrome (CS) is an endocrine disease by to glucocorticoids excess, depen dent or independent of adrenocorticotropic hormone (ACTH). The main cause is iatrogenic due to excessive use of glucocorticoids.

Objective: To show the association between prolonged use of topical corticosteroids and the development of CS. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000302DOI Listing
June 2018
9 Reads

Effects of Initiation Time of Glycemic Control on Skin Collagen Recovery in Streptozotocin-Induced Diabetic Rats.

Dermatology 2018 4;234(3-4):148-156. Epub 2018 Jul 4.

Department of Dermatology, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Background: Diabetes damages the collagen in the skin. No study has investigated the relationship between the treatment initiation time and the degree of collagen recovery. This study aimed to evaluate the effects of the initiation time of glycemic control on collagen recovery and to determine the basic molecules mediating the process. Read More

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http://dx.doi.org/10.1159/000490345DOI Listing
July 2018
5 Reads

Prevalence, predictors and comorbidity of dry skin in the general population.

J Eur Acad Dermatol Venereol 2018 Jun 28. Epub 2018 Jun 28.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Background: Dry skin is a frequent and multifaceted condition which can be associated with skin irritation, itch, patient discomfort and manifest skin disease. In spite of being frequent, little is known about the epidemiology of dry skin in the population.

Objective: To determine the prevalence of dry skin in the German adult population. Read More

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http://doi.wiley.com/10.1111/jdv.15157
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http://dx.doi.org/10.1111/jdv.15157DOI Listing
June 2018
2 Reads

Unilateral acne after facial palsy.

An Bras Dermatol 2018 Jun;93(3):441-442

Clínica Vespucio, Santiago, Chile.

We describe a case of unilateral acne which appeared after an episode of facial nerve palsy. An 18-year-old female patient presented with papules and pustules predominantly located on the side where the facial paralysis occurred. The patient suffered right facial paralysis, which was treated with prednisone and kinesiotherapy with massages, electrostimulation, and infrared light. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001108PMC
June 2018
1 Read

Pediatric Inpatient and Emergency Dermatology Consultations: A 5-Year Retrospective Analysis.

P R Health Sci J 2018 Jun;37(2):105-109

Department of Dermatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR.

Objective: To characterize and analyze the inpatient and emergency pediatric dermatology consults in our academic hospital center.

Methods: We reviewed 485 consultations that were done by the University of Puerto Rico Department of Dermatology from July 2007 to June 2012. The date, patient age and gender, consulting service, presumptive diagnosis, final diagnosis, and diagnostic procedures performed were documented for each consult. Read More

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June 2018
8 Reads

Malassezia pachydermatis from animals: Planktonic and biofilm antifungal susceptibility and its virulence arsenal.

Vet Microbiol 2018 Jul 4;220:47-52. Epub 2018 May 4.

Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza, CE, Brazil; School of Veterinary, Postgraduate Program in Veterinary Sciences, State University of Ceará, Fortaleza, CE, Brazil.

The yeast Malassezia pachydermatis is a component of the microbiota of dogs and cats, however it can cause otitis and seborrheic dermatitis in these animals. The objective of this study was to determine the antifungal susceptibility, and evaluate virulence and pathogenicity of 25 M. pachydermatis strains from animals. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.05.003DOI Listing
July 2018
2 Reads

The myrtus communis L. solution versus ketoconazole shampoo in treatment of dandruff: A double blinded randomized clinical trial.

J Pak Med Assoc 2018 May;68(5):715-720

Research Center for Traditional Medicine and History of Medicine.

Objective: To evaluate the efficacy and safety of myrtus communis L. solution in the treatment of dandruff and to compare it with ketoconazole.

Methods: This double-blind randomised clinical trial was conducted at Shiraz University of Medical Sciences, Shiraz, Iran, from December 2015 to August 2016, and comprised patients with dandruff aged 18-60 years visiting the dermatology out-patient clinic. Read More

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May 2018
2 Reads

The rapid effect of pulsed dye laser on demodex density of facial skin.

J Cosmet Laser Ther 2018 Jun 8:1-4. Epub 2018 Jun 8.

a Kayseri Health Training and Research Center, Dermatology Clinic , Health Sciences University , Kayseri , Turkey.

Background: Recently, treatment with acaricides, which is aimed at reducing excessive proliferation of demodex mites, has gained popularity due to its providing a significant improvement in the symptoms of diseases, such as rosacea, seborrhoeic dermatitis, and perioral dermatitis. The effect of IPL on demodex mites was reported in skin biopsy specimens in three patients; however, to the best of our knowledge, no study exists to date, which evaluates the effect of pulsed dye laser (PDL) on demodex density (Dd) in larger patient group. We aim here in to observe the Dd before and after PDL therapy with two different skin biopsy techniques. Read More

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https://www.tandfonline.com/doi/full/10.1080/14764172.2018.1
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http://dx.doi.org/10.1080/14764172.2018.1481509DOI Listing
June 2018
5 Reads

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development.

Br J Clin Pharmacol 2018 Oct 19;84(10):2178-2193. Epub 2018 Jul 19.

Centre for Human Drug Research, Leiden, the Netherlands.

Aims: To explore the potential of the skin microbiome as biomarker in six dermatological conditions: atopic dermatitis (AD), acne vulgaris (AV), psoriasis vulgaris (PV), hidradenitis suppurativa (HS), seborrhoeic dermatitis/pityriasis capitis (SD/PC) and ulcus cruris (UC).

Methods: A systematic literature review was conducted according to the PRISMA guidelines. Two investigators independently reviewed the included studies and ranked the suitability microbiome implementation for early phase clinical studies in an adapted GRADE method. Read More

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http://dx.doi.org/10.1111/bcp.13662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138488PMC
October 2018
3 Reads

Pigmented transverse nasal band: A distinct presentation.

J Cosmet Dermatol 2018 May 28. Epub 2018 May 28.

Skin Disease Centre, Nashik, India.

Pigmented transverse nasal band (PTNB) is an interesting morphological entity mainly of cosmetic concern. It is believed to be related to a defect in the development of the nasal cartilages and bones from childhood to adolescence. Some patients may have genetic predisposition. Read More

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http://doi.wiley.com/10.1111/jocd.12678
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http://dx.doi.org/10.1111/jocd.12678DOI Listing
May 2018
20 Reads

Current State of Nanomedicines in the Treatment of Topical Infectious Disorders.

Recent Pat Antiinfect Drug Discov 2018 ;13(2):127-150

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160 014, India.

Background: Topical infections, involving a number of diseases such as impetigo, eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the many challenges to health which stand out for their profound impact on human species. The treatment of topical infections has always been a difficult proposition because of the lack of efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery. The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa undermines the need for the development of new delivery systems to enhance the therapeutic efficacy of existing topical anti-infectives. Read More

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http://dx.doi.org/10.2174/1574891X13666180529103804DOI Listing
January 2018
2 Reads

Analysis of gene expression profiles of multiple skin diseases identifies a conserved signature of disrupted homeostasis.

Exp Dermatol 2018 Sep 30;27(9):1000-1008. Epub 2018 Jul 30.

Calico, LLC, South San Francisco, CA, USA.

Triggers of skin disease pathogenesis vary, but events associated with the elicitation of a lesion share many features in common. Our objective was to examine gene expression patterns in skin disease to develop a molecular signature of disruption of cutaneous homeostasis. Gene expression data from common inflammatory skin diseases (eg psoriasis, atopic dermatitis, seborrhoeic dermatitis and acne) and a novel statistical algorithm were used to define a unifying molecular signature referred to as the "unhealthy skin signature" (USS). Read More

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http://dx.doi.org/10.1111/exd.13694DOI Listing
September 2018

Beneficial Effects of Antioxidant Furfuryl Palmitate in Non-pharmacologic Treatments (Prescription Emollient Devices, PEDs) for Atopic Dermatitis and Related Skin Disorders.

Dermatol Ther (Heidelb) 2018 Sep 22;8(3):339-347. Epub 2018 May 22.

Dipartimento di Scienze biomediche, chirurgiche e odontoiatriche, Clinica Dermatologica, Università degli Studi di Milano, Milan, Italy.

Introduction: Atopic dermatitis (AD) is a common chronic inflammatory skin disease; it requires long-term treatments focused on symptomatic relief. Current first-line treatments include moisturizers and topical corticosteroids. Recently, topical antioxidants have been added to moisturizer formulations to alleviate mild-to-moderate AD. Read More

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http://dx.doi.org/10.1007/s13555-018-0239-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109026PMC
September 2018

is the most common bacterial agent of the skin flora of patients with seborrheic dermatitis.

Dermatol Pract Concept 2018 Apr 30;8(2):80-84. Epub 2018 Apr 30.

Department of Cardiology, Kafkas University School of Medicine, Kars, Turkey.

Background: Seborrheic dermatitis is an inflammatory skin disease that affects 1-3% of the general population. The species has been implicated as the main causative agent; however, the bacterial flora of the skin may also play role in the etiopathogenesis. Therefore, we investigated the most common bacterial agent of the skin flora of patients with seborrheic dermatitis. Read More

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http://dx.doi.org/10.5826/dpc.0802a04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955074PMC
April 2018
11 Reads

Langerhans cell histiocytosis in children: History, classification, pathobiology, clinical manifestations, and prognosis.

J Am Acad Dermatol 2018 Jun;78(6):1035-1044

ClearlyDerm Center for Dermatology, Department of Clinical Biomedical Science, Florida Atlantic University, Boca Raton, Florida.

Langerhans cell histiocytosis (LCH) is an inflammatory neoplasia of myeloid precursor cells driven by mutations in the mitogen-activated protein kinase pathway. When disease involves the skin, LCH most commonly presents as a seborrheic dermatitis or eczematous eruption on the scalp and trunk. Evaluation for involvement of other organ systems is essential, because 9 of 10 patients presenting with cutaneous disease also have multisystem involvement. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.05.059DOI Listing

Treatment of seborrheic dermatitis: a comprehensive review.

J Dermatolog Treat 2018 May 24:1-12. Epub 2018 May 24.

a Department of Dermatology & Cutaneous Surgery , University of Miami Miller School of Medicine , Miami , FL , USA.

Seborrheic dermatitis (SD) is a chronic, recurring inflammatory skin disorder that manifests as erythematous macules or plaques with varying levels of scaling associated with pruritus. The condition typically occurs as an inflammatory response to Malassezia species and tends to occur on seborrheic areas, such as the scalp, face, chest, back, axilla, and groin areas. SD treatment focuses on clearing signs of the disease; ameliorating associated symptoms, such as pruritus; and maintaining remission with long-term therapy. Read More

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http://dx.doi.org/10.1080/09546634.2018.1473554DOI Listing
May 2018
1 Read

High prevalence and correlates of human herpesvirus-6A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai.

J Med Virol 2018 Sep 25;90(9):1532-1540. Epub 2018 May 25.

MOE & MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Skin disorders vary greatly in symptom and severity, and the causes of these disorders are largely unknown. Human herpesvirus (HHV) has been shown to cause many diseases. However, the prevalence and correlation of each HHV infection with different skin disorders remains obscure. Read More

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http://dx.doi.org/10.1002/jmv.25217DOI Listing
September 2018
3 Reads

Missed opportunities in the diagnosis of human immunodeficiency virus infection in the Region of Aragon. Late diagnosis importance.

Enferm Infecc Microbiol Clin 2018 Apr 30. Epub 2018 Apr 30.

Servicio de Urgencias, Fundación Hospital de Calahorra, Logroño, España.

Introduction: Late Diagnosis (LD) of Human Immunodeficiency Virus (HIV) infection (CD4 lymphocytes <350/μl at diagnosis of the disease), deteriorates the condition of those affected and increases the probability of transmission. The objective of the present study was to analyse the prevalence of LD, to identify missed diagnostic opportunities (MDO) and to find out which level of the health care delivery system they took place.

Methods: Retrospective, observational and descriptive study of the population diagnosed with infection of HIV/AIDS in the period 2011-2015 in Aragon. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0213005X183016
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http://dx.doi.org/10.1016/j.eimc.2018.03.007DOI Listing
April 2018
3 Reads

Role of the keratin 1 and keratin 10 tails in the pathogenesis of ichthyosis hystrix of Curth Macklin.

PLoS One 2018 24;13(4):e0195792. Epub 2018 Apr 24.

Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata", Rome, Italy.

Ichthyosis Hystrix of Curth-Macklin (IH-CM) is a rare manifestation of epidermolytic ichthyosis (EI) that is characterised by generalised spiky or verrucous hyperkeratosis. The disorder is further distinguished by the presence of binucleated cells in the affected skin, whereas epidermolysis and clumping of tonofilaments, as seen in EI, are absent. While IH-CM is associated with mutations in the keratin 1 (KRT1) gene, reports to date have indicated that mutations in the KRT1 gene result in an aberrant and truncated protein tail, essentially affecting the function of the V2 domain. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195792PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918167PMC

The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin.

Clin Cosmet Investig Dermatol 2018 6;11:141-148. Epub 2018 Apr 6.

Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan.

Objective: Dry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases. Read More

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http://dx.doi.org/10.2147/CCID.S158428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896640PMC
April 2018
3 Reads

Evaluation of molecules or extracts modulating seborrhea and its consequences, using normal human culture of sebocytes and keratinocytes, skin explants models and methods: a case study.

J Cosmet Sci 2017 Mar/Apr;68(2):183-194

SEDERMA, 78612 Le Perray-en-Yvelines, France (M.P., R.C., L.L., D.E., O.E., B.S.), IRB, 36077 Altavilla Vicentina, Italy (D.T.R.).

Skin produces sebum through sebocytes. Hyper-seborrhea creates conditions for the development of inflamed cutaneous alterations through bacteria colonization triggering dead cell accumulation and pro-inflammatory mediator release. Study of sebum production, its modulation, and its consequences requires complementary models in order to evaluate the effect of molecules on cell metabolisms. Read More

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May 2018
9 Reads

Causes, pathophysiology, and treatment of pruritus in the mature patient.

Clin Dermatol 2018 Mar - Apr;36(2):140-151. Epub 2017 Oct 17.

Department of Dermatology & Miami Itch Center at the University of Miami, Leonard M. Miller School of Medicine, Miami, FL, USA. Electronic address:

Chronic itch is a common and debilitating health condition in the elderly. There are several common causes of itch in the mature population, such as skin xerosis, immunosenescence, and neuropathic changes. In addition, skin diseases, such as seborrheic dermatitis and stasis dermatitis, systemic conditions (end-stage renal disease and diabetes), or psychogenic derailments, such as depression, anxiety, and dementia, can all serve as triggers of pruritus. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.10.005DOI Listing
September 2018
33 Reads

Malassezia species retrieved from skin with pityriasis versicolor, seborrhoeic dermatitis and skin free of lesions: a comparison of two sampling methods.

Br J Dermatol 2018 Aug 30;179(2):526-527. Epub 2018 May 30.

Division of Microbiology, Department of Pathology, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1111/bjd.16521DOI Listing
August 2018
1 Read

Evaluating and Optimizing the Diagnosis of Erythematotelangiectatic Rosacea.

Dermatol Clin 2018 Apr 21;36(2):127-134. Epub 2017 Dec 21.

University of Florida College of Medicine, PO Box 100277, Gainesville, FL 32610-0277, USA.

Erythematotelangiectatic rosacea is the most prevalent rosacea subtype. Multiple dermatologic conditions may mimic erythematotelangiectatic rosacea. The authors review a comprehensive approach to evaluating subjects with a suspected diagnosis of erythematotelangiectatic rosacea and discuss findings that may warrant further investigation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635173016
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http://dx.doi.org/10.1016/j.det.2017.11.008DOI Listing
April 2018
6 Reads