3,439 results match your criteria Seborrheic Dermatitis


Facial dermatoses in general population due to personal protective masks: first observations after lockdown.

Clin Exp Dermatol 2020 Jul 13. Epub 2020 Jul 13.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Since SARS-COV-2 pandemic began, frontline healthcare workers demonstrated to develop facial dermatoses, such as acne, rosacea and seborrheic dermatitis, secondary to prolonged use of personal protective equipment (PPE). Read More

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http://dx.doi.org/10.1111/ced.14376DOI Listing

Eyelid Disorders in Ophthalmology Practice: Results from a Large International Epidemiological Study in Eleven Countries.

Ophthalmol Ther 2020 Jul 1. Epub 2020 Jul 1.

Kharkiv National Medical University, Kharkiv, Ukraine.

Purpose: Anecdotal evidence suggests that eyelid disorders are common, although estimates of prevalence vary. The current study determines the prevalence of eyelid disorders, meibomian gland dysfunction (MGD) and related diseases (specifically ocular surface disease) in a population of patients presenting for routine ophthalmologic consultations.

Methods: This cross-sectional epidemiologic survey evaluated patients presenting for routine ophthalmic visits. Read More

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http://dx.doi.org/10.1007/s40123-020-00268-4DOI Listing

Susceptibilities of strains from pityriasis versicolor, Malassezia folliculitis and seborrheic dermatitis to antifungal drugs.

Heliyon 2020 Jun 20;6(6):e04203. Epub 2020 Jun 20.

Department of Dermatology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China.

The human pathogenic yeast genus may be an etiological agent of skin disorders and has received considerable attention from dermatologists in recent years. To investigate the different susceptibilities of species to four antifungal drugs, we isolated a total of 244 strains and identified six species of from patients with clinical skin diseases. The minimum inhibitory concentration (MIC) of the four antifungal drugs was obtained by comparing the susceptibility of the isolated strains to four antifungal drugs (ketoconazole (KTZ), itraconazole (ITZ), fluconazole (FLC) and amphotericin B (Am B)). Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322256PMC

Evaluation of the effects of COVID-19 pandemic on hair diseases through a web-based questionnaire.

Dermatol Ther 2020 Jun 28:e13923. Epub 2020 Jun 28.

Department of Biostatistics and Medical Informatics, Medical Faculty, Inonu University, Malatya, Turkey.

Aim: Current quarantine conditions are a difficult process for individuals and can worsen the psychological state. Increased psychosocial stress can affect the course of many common "stress-sensitive" skin conditions. This study examined the possible effects of COVID-19 on hair and scalp diseases such as telogen effluvium (TE), alopecia areata (AA), and seborrheic dermatitis (SD) in individuals who had to stay at home for a long time and the patients' methods of dealing with these diseases. Read More

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http://dx.doi.org/10.1111/dth.13923DOI Listing

COVID-19 Pandemic & Skin Care Guidelines for Health Care Professionals.

Pak J Med Sci 2020 May;36(COVID19-S4):S115-S117

Palwasha Jalil, MBBS. Chief Resident Dermatology, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.

The Novel corona virus is bringing multiple challenges for health care professionals. Skin is the biggest organ and the first line of defense against different infections and external factors. Being the front line warriors, health care professionals are susceptible to various skin conditions due to prolonged use of personal protective equipment. Read More

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http://dx.doi.org/10.12669/pjms.36.COVID19-S4.2748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306944PMC

The Mast Cell-SCF-CB1 Interaction Is a Key Player in Seborrheic Keratosis.

J Histochem Cytochem 2020 Jul 24;68(7):461-471. Epub 2020 Jun 24.

Department of Dermatology, Graduate School of Medicine, Osaka City University, Osaka, Japan (MY-T, KS, RS, DT).

Mast cell (MC) is an important player in the development of skin diseases, including atopic dermatitis, psoriasis, and urticaria. It is reported that MC infiltration and activation are observed around various types of tumors and speculated that MCs play key roles in their pathogenesis. As MCs in human seborrheic keratosis (SK) have not been well investigated, here we focused on the MCs in SK. Read More

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http://dx.doi.org/10.1369/0022155420938031DOI Listing

Non-Steroidal Topical Therapy for Facial Seborrheic Dermatitis.

J Drugs Dermatol 2020 Jun;19(6):658-660

Seborrheic dermatitis (SD) is a chronic, recurrent, inflammatory skin disorder occurring in areas rich in sebaceous glands. It manifests clinically as erythematous macules or plaques with varying levels of scaling and associated pruritus. Although the pathogenesis of SD has yet to be fully understood, Malassezia yeasts, hormones, sebum levels, and immune response are known to play important roles. Read More

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http://dx.doi.org/10.36849/JDD.2020.10.36849/JDD.2020.5121DOI Listing

Potential role of the skin microbiota in Inflammatory skin diseases.

J Cosmet Dermatol 2020 Jun 20. Epub 2020 Jun 20.

Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China.

Background: Inflammatory skin diseases include a variety of skin diseases, such as seborrheic dermatitis, acne, atopic dermatitis, psoriasis and so on, which are more common and tend to have a significant impact on patients' quality of life. Inflammatory skin diseases often result in physical or psychological distress; however, the pathogenesis of these diseases have not been clearly elucidated. Many factors are involved in the pathogenesis of inflammatory skin diseases, including heredity, environment, immunity, epidermal barrier, mental disorders, infection and so on. Read More

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http://dx.doi.org/10.1111/jocd.13538DOI Listing

Itch in Organs Beyond the Skin.

Curr Allergy Asthma Rep 2020 Jun 19;20(9):49. Epub 2020 Jun 19.

Department of Dermatology and Cutaneous Surgery, and Itch Center University of Miami Miller School of Medicine, 1475 NW 12th Ave, Miami, FL, 33136, USA.

Purpose Of Review: The purpose of this review was to explore mechanisms, causes, and therapies of itchy conditions involving organs beyond the skin including the eyes, ears, nose, and genital region.

Recent Findings: Conditions which cause itch in these locations vary from skin diseases that extend to these areas (i.e. Read More

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http://dx.doi.org/10.1007/s11882-020-00947-zDOI Listing

Sociodemographic characteristics and spectrum of Malassezia species in individuals with and without seborrhoeic dermatitis/dandruff: A comparison of residents of the urban and rural populations.

Med Mycol 2020 Jun 18. Epub 2020 Jun 18.

Dept. of Medical Microbiology.

Seborrhoeic dermatitis/dandruff (SD/D) is a common, persistent, relapsing inflammatory condition affecting the areas rich in sebaceous glands. SD/D is widely prevalent in India but Malassezia species implicated are not well studied. To estimate the prevalence and spectrum of Malassezia species causing SD/D and understand the sociodemographic characteristics of SD/D in rural and urban populations, a total of 200 SD/D patients and 100 healthy controls (HC) from both rural and urban backgrounds were enrolled in this study. Read More

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http://dx.doi.org/10.1093/mmy/myaa050DOI Listing
June 2020
2.335 Impact Factor

Dermatologic conditions in Down syndrome: A single-center retrospective chart review.

Pediatr Dermatol 2020 Jun 10. Epub 2020 Jun 10.

Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.

Background: Current literature addressing dermatologic conditions associated with Down syndrome is limited, with emphasis on rare skin conditions and lack of consensus on the incidence of more common disorders.

Objective: We sought to evaluate dermatologic conditions in patients with Down syndrome diagnosed and managed by dermatologists.

Methods: This was a retrospective analysis of 101 pediatric and adult patients with Down syndrome seen by the University of Massachusetts Dermatology Department between 2008 and 2018. Read More

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http://dx.doi.org/10.1111/pde.14214DOI Listing

Langerhans cell histiocytosis: A great imitator.

Clin Dermatol 2020 Mar - Apr;38(2):223-234. Epub 2019 Oct 24.

Department of Dermatology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA. Electronic address:

Langerhans cell histiocytosis (LCH) is an uncommon but serious inflammatory neoplasia that affects many organs, including the skin. Though uncommon, it should remain high on a clinician's differential diagnosis in treatment-resistant cases of conditions, such as seborrheic dermatitis, diaper dermatitis, arthropod bites, and many more. A thorough history nd physical examination for each patient can aid in the diagnosis; however, if clinically suspicious for LCH, a punch biopsy should be performed. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.007DOI Listing
October 2019

Dithranol: An insight on its novel delivery cargos for psoriasis management.

Curr Drug Res Rev 2020 May 25. Epub 2020 May 25.

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana. India.

Objective: Dithranol (DTH) is a promising well known moiety that has long been used to impede and treat skin disorders, particularly psoriasis. Now a days, a rekindled interest in the use of DTH for this disorder has been observed. Side effects associated with conventional topical formulations of this moiety have aroused interest of scientific community in novel cargos for psoriasis management. Read More

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http://dx.doi.org/10.2174/2589977512666200525154954DOI Listing

Topical crisaborole is an efficacious steroid-sparing agent for treating mild-to-moderate seborrhoeic dermatitis.

J Eur Acad Dermatol Venereol 2020 May 26. Epub 2020 May 26.

Department of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1111/jdv.16673DOI Listing

Face Mask-induced Itch: A Self-questionnaire Study of 2,315 Responders During the COVID-19 Pandemic.

Acta Derm Venereol 2020 May 28;100(10):adv00152. Epub 2020 May 28.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, ul. Chalubinskiego 1, PL-50-368 Wrocław, Poland. E-mail:

Little is known about itch related to the use of face masks. This internet survey study investigated the prevalence, intensity and clinical characteristics of itch related to the use of face masks by the general public during the COVID-19 pandemic. A total of 2,315 replies were received, of which 2,307 were included in the final analysis. Read More

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http://dx.doi.org/10.2340/00015555-3536DOI Listing

An Unusual Presentation of Menkes Disease Masquerading as a Leukodystrophy with Macrocephaly.

J Pediatr Neurosci 2020 Jan-Mar;15(1):57-59. Epub 2020 Mar 18.

Department of Pediatrics, Lady Hardinge Medical College, Kalawati Saran Children's Hospital, New Delhi, India.

Background: Menkes disease is an X-linked neurodegenerative disease caused by mutation in gene, which codes for copper-transporting ATPase. It usually presents in early infancy with neuro-regression, hypotonia, seizures, and kinky hair. Magnetic resonance imaging (MRI) of the brain shows cerebral atrophy, subdural effusions, and tortuous cerebral blood vessels. Read More

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http://dx.doi.org/10.4103/JPN.JPN_141_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227752PMC

as a Novelty Model of Host-Pathogen Interaction for CBS 1878 and CBS 1879.

Front Cell Infect Microbiol 2020 5;10:199. Epub 2020 May 5.

Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de los Andes, Bogotá, Colombia.

and are lipophilic and lipid dependent yeasts, associated with the skin microbiota in humans and domestic animals, respectively. Although they are commensals, under specific conditions they become pathogens, causing skin conditions, such as pityriasis versicolor, dandruff/seborrheic dermatitis, folliculitis in humans, and dermatitis and otitis in dogs. Additionally, these species are associated with fungemia in immunocompromised patients and low-weight neonates in intensive care units with intravenous catheters or with parenteral nutrition and that are under-treatment of broad-spectrum antibiotics. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214729PMC

Genomic Multiplication and Drug Efflux Influence Ketoconazole Resistance in .

Front Cell Infect Microbiol 2020 30;10:191. Epub 2020 Apr 30.

Department of Systems Biotechnology, Chung-Ang University, Anseong, South Korea.

is an opportunistic fungal pathogen on human skin; it is associated with various skin diseases, including seborrheic dermatitis and dandruff, which are usually treated using ketoconazole. In this study, we clinically isolated ketoconazole-resistant strains (KCTC 27529 and KCTC 27550) from patients with dandruff. To understand the mechanisms of ketoconazole resistance in the isolates, their genomes were sequenced and compared with the susceptible reference strain KCTC 27527. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203472PMC

Implication of Perifollicular Clusters and Folliculotropic Distribution of Dendritic Cells in the Pathogenesis of Seborrhoeic Dermatitis.

Acta Derm Venereol 2020 Jun 15;100(13):adv00183. Epub 2020 Jun 15.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.

The pathogenesis of seborrhoeic dermatitis is controversial and remains unclear. Malassezia is considered to be a commensal fungi and is found not only in the stratum corneum but also in hair follicles. It is an important pathogenic factor in seborrhoeic dermatitis. Read More

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http://dx.doi.org/10.2340/00015555-3519DOI Listing

The effect of the "stay-at-home" policy on requests for dermatology outpatient clinic visits after the COVID-19 outbreak.

Dermatol Ther 2020 May 13:e13581. Epub 2020 May 13.

Department of Dermatology, State University of New York Downstate, New York, USA.

The Coronavirus Disease 2019 (COVID-19) emerged late in Turkey but it showed a rapid progression later. We aimed to investigate the changes in the number of patients who requested a dermatology outpatient clinic visit due to the increased social and medical burden caused by COVID-19 in Turkey during the first days of the pandemic. We also examined the most common dermatologic diseases diagnosed during the COVID-19 outbreak. Read More

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http://dx.doi.org/10.1111/dth.13581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272831PMC

Adult tinea capitis in China: A retrospective analysis from 2000 to 2019.

Mycoses 2020 May 12. Epub 2020 May 12.

Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, China.

Background: Tinea capitis (TC) is an infection of the scalp hair due to dermatophytes. Most commonly seen in prepubescent children, but data of adults tinea capitis (ATC) in China mainland are limited.

Objectives: We aimed to evaluate epidemiological, clinical and mycological characteristics of ATC in China from 2000 to 2019. Read More

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http://dx.doi.org/10.1111/myc.13102DOI Listing

Clinicopathological Features of Seborrheic-Like Dermatitis in HIV-Infected Adults: A Single Institutional Descriptive Cross-Sectional Study.

Am J Dermatopathol 2020 May 1. Epub 2020 May 1.

Division of Anatomical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and National Health Laboratory Service, Tygerberg Academic Hospital, Cape Town, South Africa.

Background: Atypical and severe clinical presentations of seborrheic-like dermatitis (SLD) are associated with HIV infection, correlating with advanced disease or low CD4 counts. Previous studies documented histological findings characteristic of seborrheic dermatitis in HIV-positive patients.

Objective: To expand current knowledge of the clinicopathological characteristics of SLD in South African HIV-seropositive individuals. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001670DOI Listing

Dermatological diseases presented before COVID-19: Are patients with psoriasis and superficial fungal infections more vulnerable to the COVID-19?

Dermatol Ther 2020 May 5:e13509. Epub 2020 May 5.

Uşak University, Department of Dermatology and Venereology, School of Medicine, Uşak, Turkey.

Recent studies have focused on the comorbid conditions of the COVID-19. According to the current studies, numerous diseases including lung disease, cardiovascular disease and immunosuppression appear to be at higher risk for severe forms of the COVID-19. To date, there are no data in the literature on the comorbid dermatologic diseases and COVID-19. Read More

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http://dx.doi.org/10.1111/dth.13509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261987PMC

Treatment of hypothyroidism using Korean medicine: 2 case reports.

Medicine (Baltimore) 2020 May;99(18):e19737

Department of Obstetrics and Gynecology, College of Korean Medicine.

Introduction: Hypothyroidism, the most common endocrine disease, comprises a deficiency of thyroid hormone, causing coldness, fatigue, and dysmenorrhea. Here, we report the improvement of hypothyroidism symptoms and thyroid hormone level normalization by using Korean herbal medicine and acupuncture therapy.

Patient Concerns: A 30-year-old woman (Case 1) presented at the clinic with continuous seborrheic dermatitis on the scalp, accompanied by dysmenorrhea. Read More

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http://dx.doi.org/10.1097/MD.0000000000019737DOI Listing

Screening and Intervention for Skin Cancer in the Galapagos.

Ann Plast Surg 2020 Jul;85(S1 Suppl 1):S143-S148

Division of Plastic and Reconstructive Surgery at Stony Brook University Hospital.

Objective: This study aimed to assess the general dermatological needs and correlation of tentative skin cancer screening diagnoses with histopathological confirmation in the highly sun-exposed locals of the Galapagos Islands.

Methods: An institutional review board-approved prospective study was performed at Blanca's House, a nonprofit surgical volunteer organization, free clinics in the Galapagos. After consent, a 40-item modified SPOTme-inspired questionnaire was completed. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002345DOI Listing

A randomized controlled clinical study of acupuncture therapy for Seborrheic alopecia in young and middle ages: Study protocol clinical trial (SPIRIT compliant).

Medicine (Baltimore) 2020 Apr;99(17):e19842

Qin Huang Dao Hospital of Traditional Chinese Medicine of HeBei North University,China.

Introduction: Seborrheic alopecia (SA) has clinical manifestations, duration of disease, and priorities. In the current situation where there are many and complicated clinical treatments, Western medicine treatment can delay and control the development of the disease and promote hair regeneration. However, some patients may aggravate symptoms after taking the drug, and the condition is easy to repeat after stopping the drug. Read More

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http://dx.doi.org/10.1097/MD.0000000000019842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220544PMC

Prevalence and cutaneous comorbidities of hidradenitis suppurativa in the German working population.

Arch Dermatol Res 2020 Apr 22. Epub 2020 Apr 22.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany.

The association of hidradenitis suppurativa with other skin diseases has not yet been investigated in larger studies based on dermatological exams. The objectives of this study are to determine the prevalence and cutaneous comorbidities of hidradenitis suppurativa in the German working population. Between 2014 and 2017, 20,112 people in 343 German companies were examined for the presence of clinical features of hidradenitis suppurativa within the framework of a cross-sectional epidemiological study based on whole-body examinations. Read More

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http://dx.doi.org/10.1007/s00403-020-02065-2DOI Listing

-Associated Skin Diseases, the Use of Diagnostics and Treatment.

Front Cell Infect Microbiol 2020 20;10:112. Epub 2020 Mar 20.

St. Johns Institute of Dermatology, Kings College London, London, United Kingdom.

Yeasts of the genus, , formerly known as , are lipophilic yeasts, which are a part of the normal skin flora (microbiome). colonize the human skin after birth and must therefore, as commensals, be normally tolerated by the human immune system. The yeasts also have a pathogenic potential where they can, under appropriate conditions, invade the stratum corneum and interact with the host immune system, both directly but also through chemical mediators. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098993PMC

The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Division of Dermatology, Department of Medicine, University of Arizona, Tucson, AZ.

Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. Read More

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February 2020

Malassezia and Staphylococcus dominate scalp microbiome for seborrheic dermatitis.

Bioprocess Biosyst Eng 2020 Mar 26. Epub 2020 Mar 26.

Beijing Institute of Biotechnology, Beijing, 10071, China.

Seborrheic dermatitis (SD) is a common disease of the human scalp that causes physical damage and psychological problems for patients. Studies have indicated that dysbiosis of the scalp microbiome results in SD. However, the specific fungal and bacterial microbiome changes related to SD remain elusive. Read More

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http://dx.doi.org/10.1007/s00449-020-02333-5DOI Listing

Activation studies of the β-carbonic anhydrases from with amines and amino acids.

J Enzyme Inhib Med Chem 2020 Dec;35(1):824-830

Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Sesto Fiorentino (Florence), Italy.

The β-carbonic anhydrase (CA, EC 4.2.1. Read More

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http://dx.doi.org/10.1080/14756366.2020.1743284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170391PMC
December 2020

New Therapeutic Candidates for the Treatment of Malassezia pachydermatis -Associated Infections.

Sci Rep 2020 Mar 17;10(1):4860. Epub 2020 Mar 17.

Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de los Andes, Bogotá, 111711, Colombia.

The opportunistic pathogen Malassezia pachydermatis causes bloodstream infections in preterm infants or individuals with immunodeficiency disorders and has been associated with a broad spectrum of diseases in animals such as seborrheic dermatitis, external otitis and fungemia. The current approaches to treat these infections are failing as a consequence of their adverse effects, changes in susceptibility and antifungal resistance. Thus, the identification of novel therapeutic targets against M. Read More

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http://dx.doi.org/10.1038/s41598-020-61729-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078309PMC

Yeasts in Veterinary Dermatology: An Updated Overview.

Front Cell Infect Microbiol 2020 28;10:79. Epub 2020 Feb 28.

Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, United Kingdom.

Lipophilic yeasts of the genus are important skin commensals and opportunistic skin pathogens in a variety of animals. The species was first isolated from the skin of a captive Indian rhinoceros with an exfoliative dermatitis in 1925, recognized as an important otic pathogen of dogs in the 1950's, and finally accepted, after several years of controversy, as a common cause of canine dermatitis in the 1990's. Since then, there has been considerable research into the biology of yeasts and their interaction with their animal hosts. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059102PMC
February 2020

Terra Firma-Forme Dermatosis: Rubbing with Alcohol Establishes the Diagnosis.

Authors:
Philip R Cohen

Skinmed 2020 1;18(1):51-52. Epub 2020 Jan 1.

Department of Dermatology, School of Medicine, University of California, San Diego, La Jolla, CA;

An 80-year-old man with a past medical history of basal cell carcinomas presented with an asymptomatic eruption on the chest during his biannual skin check for cancer. He had had no prior or current episodes of seborrheic dermatitis on the scalp, face, or chest. He showered and cleaned that area daily. Read More

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January 2020

Topical application of nanoparticles integrated supramolecular hydrogels for the potential treatment of seborrhoeic dermatitis.

Pharm Dev Technol 2020 Jul 18;25(6):748-756. Epub 2020 Mar 18.

School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.

The current application was aimed to evaluate the therapeutic potential of selenium and ketoconazole nanoparticles loaded hyaluronic acid gel against seborrhoeic dermatitis (SD). Amalgamation of ketoconazole (antifungal medication) and selenium (pro-oxidant) in an optimized formulation setting may help in the treatment of SD. In this study, selenium and ketoconazole nanoparticles loaded hyaluronic acid (HA) hydrogel was prepared by mechanical mixing followed by sonication. Read More

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http://dx.doi.org/10.1080/10837450.2020.1740932DOI Listing

Provision of primary care by specialist physicians: a systematic review.

Fam Med Community Health 2020 25;8(1):e000247. Epub 2020 Feb 25.

Department of Family Medicine, United Arab Emirates University, Al Ain, United Arab Emirates.

Patients with stable chronic diseases such as diabetes and hypertension can be safely managed at the primary care level. Yet many such patients continue to follow-up with specialists at a higher expense with no added benefit. We introduce a new term to describe this phenomenon: scope inversion, defined as the provision of primary care by specialist physicians. Read More

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http://dx.doi.org/10.1136/fmch-2019-000247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046372PMC
February 2020

Off-Label Therapeutic Potential of Crisaborole.

J Cutan Med Surg 2020 May/Jun;24(3):292-296. Epub 2020 Mar 5.

Division of Dermatology, Department of Medicine, University of Alberta, Canada.

Crisaborole, a topical phosphodiesterase-4 inhibitor, was recently approved in 2016 for the treatment of mild to moderate atopic dermatitis in adults and children greater than 2 years of age. Since that time, several case reports and a small randomized controlled trial have been published regarding the off-label use of crisaborole for the treatment of other inflammatory dermatologic disorders. This paper reviews the current, albeit limited, evidence for off-label use of crisaborole for psoriasis, seborrheic dermatitis, vitiligo, and inflammatory linear verrucous epidermal nevus. Read More

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http://dx.doi.org/10.1177/1203475420909794DOI Listing

An update on the microbiology, immunology and genetics of seborrheic dermatitis.

Exp Dermatol 2020 05 16;29(5):481-489. Epub 2020 Mar 16.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.

The underlying mechanism of seborrheic dermatitis (SD) is poorly understood but major scientific progress has been made in recent years related to microbiology, immunology and genetics. In light of this, the major goal of this article was to summarize the most recent articles on SD, specifically related to underlying pathophysiology. SD results from Malassezia hydrolysation of free fatty acids with activation of the immune system by the way of pattern recognition receptors, inflammasome, IL-1β and NF-kB. Read More

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http://dx.doi.org/10.1111/exd.14091DOI Listing

Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis.

An Bras Dermatol 2020 Mar - Apr;95(2):187-193. Epub 2020 Feb 12.

Department of Dermatology and Venereology, Faculty of Medicine, Bahçeşehir University, Istanbul, Turkey.

Background: Demodex mites are found on the skin of many healthy individuals. Demodex mites in high densities are considered to play a pathogenic role.

Objective: To investigate the association between Demodex infestation and the three most common facial dermatoses: acne vulgaris, rosacea and seborrheic dermatitis. Read More

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http://dx.doi.org/10.1016/j.abd.2019.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175027PMC

Newly Developed Anti-Dandruff Regimen, VB-3222, Delivers Enhanced Sensorial and Effective Therapeutic Benefits Against Moderate Adherent Dandruff.

Clin Cosmet Investig Dermatol 2020 21;13:187-195. Epub 2020 Feb 21.

Vyome Therapeutics Limited, New Delhi 110092, India.

Background: Uninhibited proliferation of spp., enhanced sebaceous gland activity and individual sensitivity are three prime etiological factors behind dandruff. For many dandruff sufferers, existing anti-dandruff products start yielding unsatisfactory results after a few cycles of use. Read More

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http://dx.doi.org/10.2147/CCID.S219109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041436PMC
February 2020

Inverse Psoriasis: From Diagnosis to Current Treatment Options.

Clin Cosmet Investig Dermatol 2019 31;12:953-959. Epub 2019 Dec 31.

Dermatology Clinic, University of Catania, Catania, Italy.

Inverse psoriasis represents a clinical variant of psoriasis that is sometimes difficult to diagnose due to its clinical similarity with other skin disorders involving the folds, mainly including mechanical intertrigo, fungal and bacterial infections, contact dermatitis, seborrheic dermatitis, and lichen planus. Dermoscopy represents a useful tool for an enhanced non-invasive diagnosis. The treatment of inverse psoriasis may be challenging and include topical corticosteroids, topical calcineurin inhibitors, vitamin D analogs, traditional oral systemic therapies such as cyclosporine and methotrexate, and biologic therapies. Read More

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http://dx.doi.org/10.2147/CCID.S189000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997231PMC
December 2019

Optical coherence tomography in diagnosis of inflammatory scalp disorders.

J Eur Acad Dermatol Venereol 2020 Feb 20. Epub 2020 Feb 20.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Background: The common inflammatory scalp disorders share similar clinical manifestations, and patient work up require invasive, undesirable diagnostic procedures like biopsy to ensure correct diagnosis. Optical coherence tomography (OCT) is a non-invasive high-resolution imaging modality that has found a valuable tool to assist in the diagnose and evaluation of different skin diseases.

Objectives: To describe the structural and vascular dynamic OCT (D-OCT) findings of inflammatory scalp disorders including scalp psoriasis, seborrhoeic dermatitis and contact dermatitis and to compare trichoscopy and OCT features. Read More

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http://dx.doi.org/10.1111/jdv.16304DOI Listing
February 2020

Seborrhoeic dermatitis in an oil painting at the Gothenburg Museum of Art.

Authors:
N Kluger

J Eur Acad Dermatol Venereol 2020 Feb 7. Epub 2020 Feb 7.

Department of Dermatology, Allergology and Venereology, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/jdv.16050DOI Listing
February 2020

Metagenomic analysis of a blood stain from the French revolutionary Jean-Paul Marat (1743-1793).

Infect Genet Evol 2020 Jun 29;80:104209. Epub 2020 Jan 29.

Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), 08003 Barcelona, Spain.

The French revolutionary Jean-Paul Marat (1743-1793) was assassinated in 1793 in his bathtub, where he was trying to find relief from the debilitating skin disease he was suffering from. At the time of his death, Marat was annotating newspapers, which got stained with his blood and were subsequently preserved by his sister. We extracted and sequenced DNA from the blood stain and also from another section of the newspaper, which we used for comparison. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104209DOI Listing

Gangrenous herpetic whitlow initially misdiagnosed as cellulitis.

Australas J Dermatol 2020 Jan 31. Epub 2020 Jan 31.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/ajd.13252DOI Listing
January 2020

Recalcitrant Seborrheic Dermatitis Successfully Treated With Apremilast.

J Cutan Med Surg 2020 Jan/Feb;24(1):90-91

1867 Department of Dermatology, Tufts Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1177/1203475419878162DOI Listing
January 2020

The Unna Boot: A Historical Dressing for Varicose Ulcers.

Acta Dermatovenerol Croat 2019 Dec;27(4):273-274

Assoc. Prof. Halil Tekiner, MD, PhD, Department of the History of Pharmacy and Ethics, Erciyes University School of Pharmacy , 38280 Kayseri, Turkey;

The German dermatologist Paul Gerson Unna (1850-1929) is a prominent figure in the history of medicine for pioneering modern dermatopathology and dermotherapy (Figure 1) (1). Aside from writing extensively on anatomy, histopathology, and treatment of skin diseases, he contributed to medicine in many other ways: he originated the idea of using coated pills to enhance local absorption in the intestine, introduced ammonium bituminosulfonate (ichthyol) and resorcinol into medicine, and described several skin conditions including seborrheic dermatitis. Moreover, in 1881 he established a private clinic in Hamburg, Germany, which became a leading expert center in the diagnosis and treatment of skin disorders, hosting postgraduate physicians from all over the world for training (2). Read More

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December 2019

Sulfonamide Inhibition Profile of the β-Carbonic Anhydrase from , An Opportunistic Pathogen Triggering Scalp Conditions.

Metabolites 2020 Jan 16;10(1). Epub 2020 Jan 16.

Institute of Biosciences and Bioresources, CNR, Via Pietro Castellino 111, 80131 Napoli, Italy.

The critical CO hydration reaction to bicarbonate and protons is catalyzed by carbonic anhydrases (CAs, EC 4.2.1. Read More

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http://dx.doi.org/10.3390/metabo10010039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023381PMC
January 2020