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    3169 results match your criteria Seborrheic Dermatitis

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    [Cutaneous myiasis due to Cochliomyia hominivorax associated with seborrheic dermatitis].
    Rev Med Chil 2017 Feb;145(2):250-254
    Laboratorio de Parasitología Básico-Clínico, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
    Myiasis is an infestation of tissues and organs of humans and animals by Diptera larvae (flies, horseflies, mosquitoes). They are located at different body sites, and classified clinically as cutaneous, visceral and cavitary. We report a 26-year-old woman with a history of seborrheic dermatitis and recent trip to Brazil. Read More

    Advances in pharmacotherapeutic management of common skin diseases in neonates and infants.
    Expert Opin Pharmacother 2017 May 21;18(7):717-725. Epub 2017 Apr 21.
    a Dermatology, Department of Experimental, Diagnostic and Specialty Medicine , Sant'Orsola-Malpighi Hospital, University of Bologna , Bologna , Italy.
    Introduction: neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Read More

    Differential Diagnosis of Diaper Dermatitis.
    Clin Pediatr (Phila) 2017 May;56(5_suppl):16S-22S
    1 Johns Hopkins Children's Center, Baltimore, MD, USA.
    Mild diaper dermatitis often occurs in children before toilet training is complete, particularly from 9 to 12 months of age, and the most common presentation is an irritant contact dermatitis. Diaper dermatitis may account for up to 25% of dermatology visits to health care providers during the first year of life. Fortunately, since the introduction of hypoallergenic, superabsorbent modern disposable diapers, the incidence and severity of irritant and allergic contact dermatitis has decreased dramatically. Read More

    Association of Dermatoses with Duration and Quantum of Alcohol Intake: A Comparative Cross-sectional Study.
    Indian J Dermatol 2017 Mar-Apr;62(2):184-190
    Department of Dermatology, Dr. D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India.
    Background: Chronic alcohol intake impacts skin directly, through organ dysfunction or by modifying preexisting dermatoses. However, dermatoses afflicting chronic alcoholics figure in a few studies only.

    Aim: This study aims to correlate the spectrum of dermatoses in chronic alcoholics with the quantum/duration of alcohol intake and raised liver transaminases. Read More

    Targeting Malassezia species for novel synthetic and natural antidandruff agents.
    Curr Med Chem 2017 Apr 4. Epub 2017 Apr 4.
    Neurofarba Dept., Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence). Italy.
    Malassezia spp. are lipophilic yeasts not only present in the normal skin microflora, but also responsible of skin-related diseases (pityriasis versicolor, seborrheic/atopic dermatitis and dandruff) as well as systemic fungal infections in humans and animals. Their treatment and eradication are mainly based on old azole drugs, which are characterized by poor compliance, unpredictable clinical efficacy, emerging resistance and several side effects. Read More

    Knowledge and Behavior Regarding Cosmetics in Koreans Visiting Dermatology Clinics.
    Ann Dermatol 2017 Apr 24;29(2):180-186. Epub 2017 Mar 24.
    Arumdaun Nara Clinic, Seoul, Korea.
    Background: Cosmetics can affect the skin condition profoundly, and yet no survey has been performed in Koreans visiting dermatology clinics.

    Objective: To assess knowledge and consumer behavior regarding cosmetics in Koreans visiting dermatology clinics.

    Methods: A questionnaire consisting of 43 questions concerning demographics and use/knowledge/selection/purchase of cosmetics was given to patients and accompanying persons who visited dermatologic clinics in university and private clinic settings. Read More

    [How I explore… scalp and hairin erythemato-squamous disorders].
    Rev Med Liege 2016 Oct;71(10):460-462
    Service de Dermatopathologie, CHU de Liège, Belgique.
    In their early stages, some dermatoses of the scalp such as psoriasis seborrheic dermatitis, tinea capitis and discoid lupus erythematosus are often hardly noticeable to others. However, the eruptions are occasionally severe and extensive. Reaching an adequate diagnosis is of utmost impor¬tance for an adequate healthcare. Read More

    Real-Time PCR Identification of Six Malassezia Species.
    Curr Microbiol 2017 Jun 22;74(6):671-677. Epub 2017 Mar 22.
    Fungal and Parasitic Molecular Biology Laboratory, Faculty of Medicine, University of Sfax, Rue Magida Boulila, Sfax, 3029, Tunisia.
    Lipophilic yeast Malassezia species is widely found on the skin surface of humans and other animals. This fungus can cause pityriasis versicolor, Malassezia folliculitis, and seborrheic dermatitis. Still now, there is a problem with species identification of Malassezia with conventional methods. Read More

    Skin disorders in Parkinson's disease: potential biomarkers and risk factors.
    Clin Cosmet Investig Dermatol 2017 9;10:87-92. Epub 2017 Mar 9.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    Parkinson's disease (PD) is one of the most common neurodegenerative disorders, characterized by a symptom triad comprising resting tremor, rigidity, and akinesia. In addition, non-motor symptoms of PD are well recognized and often precede the overt motor manifestations. Cutaneous manifestations as markers of PD have long been discussed, and cumulative evidence shows an increased prevalence of certain dermatological disorders in PD. Read More

    Global Skin Disease Morbidity and Mortality: An Update From the Global Burden of Disease Study 2013.
    JAMA Dermatol 2017 Mar 1. Epub 2017 Mar 1.
    Institute for Health Metrics and Evaluation, University of Washington, Seattle.
    Importance: Disability secondary to skin conditions is substantial worldwide. The Global Burden of Disease Study 2013 includes estimates of global morbidity and mortality due to skin diseases.

    Objective: To measure the burden of skin diseases worldwide. Read More

    Common spongiotic dermatoses.
    Semin Diagn Pathol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Radiation Oncology, The Ohio State University, Columbus, OH, USA.
    This review article focuses on the spongiotic tissue reaction pattern and some of the common entities that practicing pathologists can frequently encounter in their practice. The spongiotic tissue reaction pattern is the single most common one encountered in the routine analysis of inflammatory dermatoses, and the most non-specific one as well. Spongiotic dermatoses include a very large list of disorders which are best grouped under neutrophilic, eosinophilic, miliarial, follicular and pityriasiform forms of spogiosis. Read More

    Current status in diagnosis of atopic dermatitis in China.
    Allergy 2017 Feb 24. Epub 2017 Feb 24.
    Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    In China, eczema and atopic dermatitis (AD) have been traditionally considered as 2 distinct entities. Eczema typically referred to the milder phenotypes or to phenotypes with atypical morphology and distribution of lesions and many dermatologists have ever recognized that the "eczema" diagnosed clinically by them is actually milder phenotypes or phenotypes with atypical morphology and distribution of lesions of AD. Moreover, AD, contact dermatitis, diaper dermatitis, perioral dermatitis, halo dermatitis, pompholyx, seborrheic dermatitis, etc. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Estrogenic activity of zinc pyrithione: An in vivo and in vitro study.
    Environ Health Toxicol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Bio Health Science, Changwon National University , Changwon-si, Gyeongnam , Korea.
    Objectives: Zinc pyrithione is commonly used to prevent dandruff and seborrheic dermatitis. Many consumers are exposed daily to high doses of zinc pyrithione, causing serious concerns about its toxicity. The reproductive and developmental toxicities were previously reported in pregnant rats. Read More

    Distribution of Malassezia Species in Patients with Different Dermatological Disorders and Healthy Individuals.
    Acta Dermatovenerol Croat 2016 Dec;24(4):274-281
    Professor Asja Prohić, MD, PhD, Department of Dermatovenerology, University Clinical Center of Sarajevo, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina;
    There are differences with respect to the commonly isolated Malassezia species, not only between healthy individuals and the patients with various skin diseases, but also between different countries. We investigated the species composition of Malassezia microflora on the skin of patients with Malassezia-associated diseases and of healthy subjects (HS). Two hundred and fifty skin scrapings from patients with pityriasis versicolor (PV), seborrheic dermatitis (SD), atopic dermatitis (AD), psoriasis (PS), and healthy subjects (HS), fifty each, were inoculated into Sabouraud dextrose agar and into modified Dixon agar and identified using conventional culture-based methods. Read More

    A novel cosmetic antifungal/anti-inflammatory topical gel for the treatment of mild to moderate seborrheic dermatitis of the face: a open-label trial utilizing clinical evaluation and erythemadirected digital photography.
    G Ital Dermatol Venereol 2017 Jan 24. Epub 2017 Jan 24.
    Dermatology Clinic, University of Catania, Catania, Italy -
    Bakground: Topical cosmetic agents may play a role in the management of facial seborrheic dermatitis by reducing inflammation and scale production. Advanced digital photography, equipped with technology able to provide a detailed evaluation of red skin components corresponding to vascular flare (erythema-directed digital photography), is a useful tool for evaluation of erythema in patients affected by inflammatory dermatoses. The aim of this study was to assess the efficacy and safety of a new cosmetic topical gel containing ciclopiroxolamine, lactoferrin, glycero-phosphoinositol (GPI) and Aloe vera, for the treatment of facial seborrheic dermatitis by clinical and advanced digital photography evaluation. Read More

    The mPEG-PCL Copolymer for Selective Fermentation of Staphylococcus lugdunensis Against Candida parapsilosis in the Human Microbiome.
    J Microb Biochem Technol 2016 Aug 19;8(4):259-265. Epub 2016 Jun 19.
    Department of Dermatology, University of California, San Diego, CA, USA; Moores Cancer Center; University of California, San Diego, CA, USA.
    Many human skin diseases, such as seborrheic dermatitis, potentially occur due to the over-growth of fungi. It remains a challenge to develop fungicides with a lower risk of generating resistant fungi and non-specifically killing commensal microbes. Our probiotic approaches using a selective fermentation initiator of skin commensal bacteria, fermentation metabolites or their derivatives provide novel therapeutics to rein in the over-growth of fungi. Read More

    Collapse of human scalp microbiome network in dandruff and seborrhoeic dermatitis.
    Exp Dermatol 2017 Jan 17. Epub 2017 Jan 17.
    Skin Research Institute, Amorepacific Corporation R&D Center, Yongin, Korea.
    We investigate the relationship between scalp microbiota and dandruff/seborrhoeic dermatitis (D/SD), an unpleasant scalp disorder common in human populations. Bacterial and fungal community analyses on scalp of 102 Korean were performed by next-generation sequencing. Overall scalp microbiome composition significantly differed between normal and disease groups, and especially co-occurrence network of dominant members was breakdown in disease groups. Read More

    Prevalence of hormonal and endocrine dysfunction in patients with lichen planopilaris (LPP): A retrospective data analysis of 168 patients.
    J Am Acad Dermatol 2017 Feb;76(2):314-320
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:
    Background: Studies on the pathophysiology and comorbidities associated with lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are limited.

    Objective: The purpose of this study was to determine the prevalence of androgen excess in the postmenopausal LPP population, in relation to demographics and comorbidities.

    Methods: A retrospective data analysis of 413 patients with LPP, FFA, and LPP/FFA seen in the Department of Dermatology at the Cleveland Clinic Foundation in Ohio between 2005 and 2015 was conducted. Read More

    Cutaneous features of myotonic dystrophy types 1 and 2: Implication of premature aging and vitamin D homeostasis.
    Neuromuscul Disord 2017 Feb 16;27(2):163-169. Epub 2016 Nov 16.
    Department of Systems Medicine, Division of Neurology, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy; Department of Experimental Medicine and Surgery, Division of Clinical Biochemistry, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy. Electronic address:
    Skin changes have been described in myotonic dystrophy type 1 (DM1). However, whether and in which way skin is a target of specific disease alterations in DM1 and DM2 has not been yet clarified. This study aims to explore cutaneous features of DM1 and DM2 patients. Read More

    Diversity in Dermatology Clinical Trials: A Systematic Review.
    JAMA Dermatol 2017 Jan 4. Epub 2017 Jan 4.
    Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Importance: Though there have been significant shifts in US demographic data over the past 50 years, research cohorts lack full racial and ethnic representation. There is little data available regarding the diversity of dermatology research cohorts with respect to sex, race, and ethnicity.

    Objective: To characterize and assess the representation of racial and ethnic minorities and women in randomized controlled trials across a range of dermatologic conditions. Read More

    Nekam's disease.
    Indian Dermatol Online J 2016 Nov-Dec;7(6):520-522
    Department of DVL, Katuri Medical College, Guntur, Andhra Pradesh, India.
    Keratosis lichenoides chronica also known as Nekam's disease is a rare mucocutaneous disorder, characterized clinically by asymptomatic violaceous keratotic papules arranged in linear, reticular, or plaque form usually on the trunk and extremities and histologically by interface dermatitis. The disease is considered rare with only 128 cases being reported in the literature till date and very few from India. We report a case of a 40-year-old man who presented with constellation of features of lichen planus, seborrheic dermatitis, and apthous ulcers, which upon workup was found to be Nekam's disease. Read More

    Recent Advances in Pharmacotherapeutic Paradigm of Mild to Recalcitrant Atopic Dermatitis.
    Crit Rev Ther Drug Carrier Syst 2016 ;33(3):213-263
    Department of Pharmacology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia.
    Atopic dermatitis (AD) is a common, chronic skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin E (IgE), T lymphocytes, and mast cells. The key factors responsible for the pathophysiology of this disease are immunological disorders and defects in epidermal barrier properties. Pruritus, intense itching, psychological stress, deprived physical and mental performance, and sleep disturbance are the hallmark features of this dermatological disorder. Read More

    Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study.
    Ann Dermatol 2016 Dec 23;28(6):733-739. Epub 2016 Nov 23.
    Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.; Research Institute of Medical Science, Konkuk University, Seoul, Korea.
    Background: Seborrheic dermatitis (SD) is a multifactorial disease; Malassezia species play an important role in its pathogenesis.

    Objective: We aimed to determine whether a cream containing climbazole/piroctone olamine (C/P cream), antifungal agents with expected efficacy against Malassezia species, could improve SD symptoms.

    Methods: We instructed 24 patients with mild-to-moderate SD to apply the C/P cream and emollient cream on the right and left sides of the face, respectively, every morning and evening for 4 weeks. Read More

    Study of infections among human immunodeficiency virus/acquired immunodeficiency syndrome patients in Shadan Hospital, Telangana, India.
    Indian J Sex Transm Dis 2016 Jul-Dec;37(2):147-150
    Department of Dermatology and STD, Shadan Institute of Medical Sciences, Teaching Hospital and Research Centre (A Post Graduate Institute), Hyderabad, Telangana, India.
    Background: Human immunodeficiency virus (HIV) pandemicity is a major concern today as it causes greater loss of productivity than any other disease. HIV infection leads to profound immune deficiency and patients become highly susceptible to opportunistic infections (OIs). HIV epidemic in India is heterogeneous in nature, both in terms of routes of transmission as well as geographical spread. Read More

    Whole genome sequencing analysis of the cutaneous pathogenic yeast Malassezia restricta and identification of the major lipase expressed on the scalp of patients with dandruff.
    Mycoses 2017 Mar 24;60(3):188-197. Epub 2016 Nov 24.
    Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea.
    Malassezia species are opportunistic pathogenic fungi that are frequently associated with seborrhoeic dermatitis, including dandruff. Most Malassezia species are lipid dependent, a property that is compensated by breaking down host sebum into fatty acids by lipases. In this study, we aimed to sequence and analyse the whole genome of Malassezia restricta KCTC 27527, a clinical isolate from a Korean patient with severe dandruff, to search for lipase orthologues and identify the lipase that is the most frequently expressed on the scalp of patients with dandruff. Read More

    Non-dermatophyte Dermatoses Mimicking Dermatophytoses in Animals.
    Mycopathologia 2017 Feb 16;182(1-2):113-126. Epub 2016 Nov 16.
    UP Interactions Cellules Environnement, VetAgro Sup, Univ Lyon, 69280, Marcy l'Etoile, France.
    Dermatophytoses in animals are fungal diseases of the skin caused by dermatophyte fungi of the genus Microsporum or Trichophyton. Because the infection is generally follicular, the most common clinical sign is one or many circular areas of alopecia with variable erythema, scaling and crusting, and the primary differential diagnoses are follicular infections, such as bacterial folliculitis and demodicosis. Although dermatophyte folliculitis or ringworm is the most commonly observed lesion of dermatophytoses in animals, other presentations may be observed according to the host species and the dermatophyte involved: dermatophyte folliculitis or ringworm, scaling and crusting in dermatophytosis due to Microsporum persicolor, nodule in case of kerion or mycetoma, matted hairs, seborrheic dermatosis or miliary dermatitis in cats, generalized exfoliative dermatoses in dogs, cats and horses, superficial non-follicular pustules, papules and macules in the Devon Rex cat, pruritic dermatophytoses in dogs, cats and horses, and onychomycosis in dogs, cats and horses. Read More

    Pityriasis amiantacea: a study of seven cases.
    An Bras Dermatol 2016 Sep-Oct;91(5):694-696
    Universidade Federal do Rio de Janeiro (UFRJ) - Rio de Janeiro (RJ), Brazil.
    Pityriasis amiantacea was first described in 1832. The disease may be secondary to any skin condition that primarily affects the scalp, including seborrheic dermatitis. Its pathogenesis remains uncertain. Read More

    Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review.
    Am J Clin Dermatol 2017 Apr;18(2):193-213
    Mediprobe Research Inc., 645 Windermere Road, London, ON, Canada.
    Background: Facial seborrheic dermatitis (SD), a chronic inflammatory skin condition, can impact quality of life, and relapses can be frequent. Three broad categories of agents are used to treat SD: antifungal agents, keratolytics, and corticosteroids. Topical therapies are the first line of defense in treating this condition. Read More

    Contact Alopecia: Improvement of Alopecia with Discontinuation of Fluocinolone Oil in Individuals Allergic to Balsam Fragrance.
    Pediatr Dermatol 2017 Jan 25;34(1):e57-e60. Epub 2016 Oct 25.
    Department of Dermatology, Loma Linda University, Loma Linda, California.
    Inflammatory scalp dermatoses can be associated with alopecia, which is nonscarring and reversible in its early stages. This association has been described in seborrheic dermatitis, psoriasis, and atopic dermatitis. We describe three girls with alopecia aggravated by contact allergy to balsam fragrances. Read More

    Low-dose oral isotretinoin for moderate to severe seborrhea and seborrheic dermatitis: a randomized comparative trial.
    Int J Dermatol 2017 Jan 25;56(1):80-85. Epub 2016 Oct 25.
    Department of Dermatology, Universidade Federal de São Paulo (Federal University of São Paulo [UNIFESP]), São Paulo, SP, Brazil.
    Background: The efficacy of low-dose oral isotretinoin in the treatment of seborrhea and seborrheic dermatitis has been poorly investigated in randomized studies.

    Objectives: This study was designed to determine the efficacy and safety of low-dose oral isotretinoin in the treatment of moderate to severe seborrhea and seborrheic dermatitis on the scalp and/or face.

    Methods: A randomized, comparative clinical trial, using two groups, was conducted over 6 months. Read More

    Validation of diagnostic accuracy with whole-slide imaging compared with glass slide review in dermatopathology.
    J Am Acad Dermatol 2016 Dec 11;75(6):1229-1237. Epub 2016 Oct 11.
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota; Division of Dermatopathology and Cutaneous Immunopathology, Department of Dermatology, Mayo Clinic, Rochester, Minnesota. Electronic address:
    Background: Teledermatopathology has evolved from static images to whole slide imaging (WSI), which allows for remote viewing and manipulation of tissue sections. Previous studies of WSI in teledermatopathology predated College of American Pathologists (CAP) telepathology validation guidelines.

    Objective: We conducted a comprehensive retrospective WSI validation study of routine dermatopathology cases, adhering to CAP guidelines. Read More

    Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J).
    J Dermatol 2017 Apr 11;44(4):355-362. Epub 2016 Oct 11.
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA.
    Psoriasis, a chronic, immune-mediated skin disease characterized by red, scaly plaques, affects approximately 0.3% of the population in Japan. The aim of this open-label study was to evaluate the long-term efficacy and safety of ixekizumab, a humanized, anti-interleukin-17A monoclonal antibody, in Japanese patients with plaque psoriasis (n = 78, including 11 psoriatic arthritis), erythrodermic psoriasis (n = 8) and generalized pustular psoriasis (n = 5). Read More

    The role of topical anesthetics in the management of chronic pruritus.
    J Dermatolog Treat 2016 Sep 30:1-16. Epub 2016 Sep 30.
    a Department of Dermatology , Johns Hopkins University School of Medicine , Baltimore , MD , United States.
    Chronic itch is a debilitating symptom that significant decreases patients' quality of life. Topical corticosteroids and antihistamines are commonly used for itch. However, these therapies are not long-term solutions for chronic pruritus because of their feared side effects, including skin atrophy and cognitive impairment, respectively. Read More

    Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial.
    Dermatol Pract Concept 2016 Jul 31;6(3):11-6. Epub 2016 Jul 31.
    Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Few studies have examined the effect of seborrheic dermatitis (SD) and/or its consequent therapy on a patient's quality of life. Itraconazole has been suggested as an effective therapy for severe SD but its impact on Quality of Life (QoL) in these patients has never been studied before.

    Objective: The study aimed to verify the efficacy of the itraconazole on the quality of life in patients with moderate to severe SD. Read More

    Prospective Case Series of Cutaneous Adverse Effects Associated With Dabrafenib and Trametinib.
    J Cutan Med Surg 2017 Jan/Feb;21(1):54-59. Epub 2016 Sep 22.
    1 McGill University, Division Dermatology, Montréal, QC, Canada.
    Background: Dabrafenib, a novel selective small-molecule inhibitor of BRAF, has been shown to increase overall survival in patients with unresectable metastatic melanoma harboring the BRAF V600E mutation. The development of resistance has led to combination therapy with selective MEK inhibitor trametinib. Compared with vemurafenib, dabrafenib is a more recent BRAF inhibitor approved by the Food and Drug Administration in May 2013 for metastatic melanoma; fewer data are available in the current literature regarding cutaneous toxicity. Read More

    Yellow hair following sequential application of bacitracin zinc and selenium sulfide: Report of acquired xanthotrichosis and review of yellow hair discoloration.
    Dermatol Online J 2016 Jun 15;22(6). Epub 2016 Jun 15.
    Department of Dermatology, University of California San Diego, San Diego, CA.
    BackgroundAcquired yellow hair (xanthotrichosis) can result from the deposition of pigmented compounds on the hair shaft or from chemical modification of hair pigment and protein molecules.PurposeA white-haired 77-year-old woman who developed xanthotrichosis of her scalp hair following the sequential application of bacitracin zinc ointment and selenium sulfide 2.5% lotion is described and the causes of yellow hair discoloration are reviewed. Read More

    Dermoscopy in General Dermatology: A Practical Overview.
    Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

    Metabolic Syndrome in Childhood: Rare Case of Alstrom Syndrome with Blindness.
    Indian J Clin Biochem 2016 Oct 28;31(4):480-2. Epub 2015 Dec 28.
    Department of Pediatrics, Kasturba Medical College, Manipal University, Mangalore, India.
    Alstrom's syndrome (AS) is a rare autosomal recessive ciliopathic condition affecting 1:10,00,000 children. It's a single gene disorder of ALMS1 on chromosome 2 with multisystem involvement with cone-rod retinal dystrophy causing juvenile blindness, obesity, insulin resistance, type 2 Diabetes mellitus, hypogonadism and sensorineural hearing loss. Till now only 800 patients with this disorder has been identified so far. Read More

    Serum Biotin Levels in Women Complaining of Hair Loss.
    Int J Trichology 2016 Apr-Jun;8(2):73-7
    Center for Dermatology and Hair Diseases Professor Trüeb, Zurich-Wallisellen, Switzerland.
    Biotin is a coenzyme for carboxylase enzymes that assist various metabolic reactions involved in fatty acid synthesis, branched-chain amino acid catabolism, and gluconeogenesis important for maintenance of healthy skin and hair. Due to its availability, affordability, and effective marketing for this purpose, biotin is a popular nutritional supplement for treatment of hair loss. However, there are little data on the frequency of biotin deficiency in patients complaining of hair loss and on the value of oral biotin for treatment of hair loss that is not due to an inborn error of biotin metabolism or deficiency. Read More

    iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis.
    Arch Dermatol Res 2016 Nov 6;308(9):631-642. Epub 2016 Sep 6.
    L'Oreal Research and Innovation, 1 Avenue Eugène Schueller, 93600, Aulnay-Sous-Bois, France.
    The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological functions provided new insights into the affected metabolic pathways of a dandruff scalp. Read More

    Paraneoplastic Itch Management.
    Curr Probl Dermatol 2016 23;50:149-54. Epub 2016 Aug 23.
    Paraneoplastic itch occurs as the result of a systemic reaction to an underlying malignancy. Paraneoplastic itch is most commonly associated with lymphoproliferative malignancies and solid tumors that result in cholestasis. Paraneoplastic itch may occur in the absence of a primary rash or in association with dermatologic conditions such as erythroderma, acanthosis nigricans, dermatomyositis, Grover's disease, and eruptive seborrheic keratosis. Read More

    Itch in Special Skin Locations Management.
    Curr Probl Dermatol 2016 23;50:111-5. Epub 2016 Aug 23.
    Department of Dermatology, University Hospital of Brest, and Laboratory of Neurosciences of Brest, University of Western Brittany, Brest, France.
    Itch management can be particularly complicated in some small areas like the scalp or the anogenital region for many reasons: the frequently poor diagnosis of the causes of itch in these areas, the dense innervation of these areas, and the symbolic value of these areas for the human psyche. The diagnosis of itchy scalp is easier than that of anogenital pruritus. Clinical examination and a careful inventory of all diseases of the patient and of the local environment are necessary. Read More

    Indole 3-acetic acid-photodynamic therapy in the treatment of multiple actinic keratoses: A proof of concept pilot study.
    Photodiagnosis Photodyn Ther 2016 Dec 23;16:17-22. Epub 2016 Aug 23.
    Department of Surgery and Translational Medicine, Division of Dermatology, University of Florence Medical School, Florence, Italy.
    Background: Actinic Keratoses (AK) are considered a form of in situ Squamous Cell Carcinoma (SCC) arising on chronically photoexposed skin. PDT with ALA or MAL is an effective treatment for multiple AK due its high Overall Response Ratio (ORR) but is burdened by important drawbacks: time-consumption, pain and high costs. Indole-3 acetic acid (IAA) is a newly described photosensitizer with proven clinical efficacy on seborrheic dermatitis and acne vulgaris. Read More

    Prevalence and related factors of psoriasis and seborrheic dermatitis: a community-based study.
    Turk J Med Sci 2016 Feb 17;46(2):303-9. Epub 2016 Feb 17.
    Department of Internal Medicine, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
    Background/aim: We aimed to determine the prevalence of psoriasis (PS) and seborrheic dermatitis (SD) (erythematous-squamous diseases) in our region and reveal the frequently encountered associated factors to aid in planning appropriate healthcare.

    Materials And Methods: A community-based study was conducted with 85 sample groups that reflected the population rate and demography of Tokat Province in northern Anatolia.

    Results: In this community, the prevalence of PS in people older than 20 years of age was 1. Read More

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