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    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Estrogenic activity of zinc pyrithione: An in vivo and in vitro study.
    Environ Health Toxicol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Bio Health Science, Changwon National University , Changwon-si, Gyeongnam , Korea.
    Objectives: Zinc pyrithione is commonly used to prevent dandruff and seborrheic dermatitis. Many consumers are exposed daily to high doses of zinc pyrithione, causing serious concerns about its toxicity. The reproductive and developmental toxicities were previously reported in pregnant rats. Read More

    Distribution of Malassezia Species in Patients with Different Dermatological Disorders and Healthy Individuals.
    Acta Dermatovenerol Croat 2016 Dec;24(4):274-281
    Professor Asja Prohić, MD, PhD, Department of Dermatovenerology, University Clinical Center of Sarajevo, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina;
    There are differences with respect to the commonly isolated Malassezia species, not only between healthy individuals and the patients with various skin diseases, but also between different countries. We investigated the species composition of Malassezia microflora on the skin of patients with Malassezia-associated diseases and of healthy subjects (HS). Two hundred and fifty skin scrapings from patients with pityriasis versicolor (PV), seborrheic dermatitis (SD), atopic dermatitis (AD), psoriasis (PS), and healthy subjects (HS), fifty each, were inoculated into Sabouraud dextrose agar and into modified Dixon agar and identified using conventional culture-based methods. Read More

    A novel cosmetic antifungal/anti-inflammatory topical gel for the treatment of mild to moderate seborrheic dermatitis of the face: a open-label trial utilizing clinical evaluation and erythemadirected digital photography.
    G Ital Dermatol Venereol 2017 Jan 24. Epub 2017 Jan 24.
    Dermatology Clinic, University of Catania, Catania, Italy -
    Bakground: Topical cosmetic agents may play a role in the management of facial seborrheic dermatitis by reducing inflammation and scale production. Advanced digital photography, equipped with technology able to provide a detailed evaluation of red skin components corresponding to vascular flare (erythema-directed digital photography), is a useful tool for evaluation of erythema in patients affected by inflammatory dermatoses. The aim of this study was to assess the efficacy and safety of a new cosmetic topical gel containing ciclopiroxolamine, lactoferrin, glycero-phosphoinositol (GPI) and Aloe vera, for the treatment of facial seborrheic dermatitis by clinical and advanced digital photography evaluation. Read More

    The mPEG-PCL Copolymer for Selective Fermentation of Staphylococcus lugdunensis Against Candida parapsilosis in the Human Microbiome.
    J Microb Biochem Technol 2016 Aug 19;8(4):259-265. Epub 2016 Jun 19.
    Department of Dermatology, University of California, San Diego, CA, USA; Moores Cancer Center; University of California, San Diego, CA, USA.
    Many human skin diseases, such as seborrheic dermatitis, potentially occur due to the over-growth of fungi. It remains a challenge to develop fungicides with a lower risk of generating resistant fungi and non-specifically killing commensal microbes. Our probiotic approaches using a selective fermentation initiator of skin commensal bacteria, fermentation metabolites or their derivatives provide novel therapeutics to rein in the over-growth of fungi. Read More

    Prevalence of hormonal and endocrine dysfunction in patients with lichen planopilaris (LPP): A retrospective data analysis of 168 patients.
    J Am Acad Dermatol 2017 Feb;76(2):314-320
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:
    Background: Studies on the pathophysiology and comorbidities associated with lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are limited.

    Objective: The purpose of this study was to determine the prevalence of androgen excess in the postmenopausal LPP population, in relation to demographics and comorbidities.

    Methods: A retrospective data analysis of 413 patients with LPP, FFA, and LPP/FFA seen in the Department of Dermatology at the Cleveland Clinic Foundation in Ohio between 2005 and 2015 was conducted. Read More

    Cutaneous features of myotonic dystrophy types 1 and 2: Implication of premature aging and vitamin D homeostasis.
    Neuromuscul Disord 2017 Feb 16;27(2):163-169. Epub 2016 Nov 16.
    Department of Systems Medicine, Division of Neurology, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy; Department of Experimental Medicine and Surgery, Division of Clinical Biochemistry, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy. Electronic address:
    Skin changes have been described in myotonic dystrophy type 1 (DM1). However, whether and in which way skin is a target of specific disease alterations in DM1 and DM2 has not been yet clarified. This study aims to explore cutaneous features of DM1 and DM2 patients. Read More

    Diversity in Dermatology Clinical Trials: A Systematic Review.
    JAMA Dermatol 2017 Jan 4. Epub 2017 Jan 4.
    Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Importance: Though there have been significant shifts in US demographic data over the past 50 years, research cohorts lack full racial and ethnic representation. There is little data available regarding the diversity of dermatology research cohorts with respect to sex, race, and ethnicity.

    Objective: To characterize and assess the representation of racial and ethnic minorities and women in randomized controlled trials across a range of dermatologic conditions. Read More

    Nekam's disease.
    Indian Dermatol Online J 2016 Nov-Dec;7(6):520-522
    Department of DVL, Katuri Medical College, Guntur, Andhra Pradesh, India.
    Keratosis lichenoides chronica also known as Nekam's disease is a rare mucocutaneous disorder, characterized clinically by asymptomatic violaceous keratotic papules arranged in linear, reticular, or plaque form usually on the trunk and extremities and histologically by interface dermatitis. The disease is considered rare with only 128 cases being reported in the literature till date and very few from India. We report a case of a 40-year-old man who presented with constellation of features of lichen planus, seborrheic dermatitis, and apthous ulcers, which upon workup was found to be Nekam's disease. Read More

    Recent Advances in Pharmacotherapeutic Paradigm of Mild to Recalcitrant Atopic Dermatitis.
    Crit Rev Ther Drug Carrier Syst 2016 ;33(3):213-263
    Department of Pharmacology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300, Kuala Lumpur, Malaysia.
    Atopic dermatitis (AD) is a common, chronic skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin E (IgE), T lymphocytes, and mast cells. The key factors responsible for the pathophysiology of this disease are immunological disorders and defects in epidermal barrier properties. Pruritus, intense itching, psychological stress, deprived physical and mental performance, and sleep disturbance are the hallmark features of this dermatological disorder. Read More

    Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study.
    Ann Dermatol 2016 Dec 23;28(6):733-739. Epub 2016 Nov 23.
    Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.; Research Institute of Medical Science, Konkuk University, Seoul, Korea.
    Background: Seborrheic dermatitis (SD) is a multifactorial disease; Malassezia species play an important role in its pathogenesis.

    Objective: We aimed to determine whether a cream containing climbazole/piroctone olamine (C/P cream), antifungal agents with expected efficacy against Malassezia species, could improve SD symptoms.

    Methods: We instructed 24 patients with mild-to-moderate SD to apply the C/P cream and emollient cream on the right and left sides of the face, respectively, every morning and evening for 4 weeks. Read More

    Study of infections among human immunodeficiency virus/acquired immunodeficiency syndrome patients in Shadan Hospital, Telangana, India.
    Indian J Sex Transm Dis 2016 Jul-Dec;37(2):147-150
    Department of Dermatology and STD, Shadan Institute of Medical Sciences, Teaching Hospital and Research Centre (A Post Graduate Institute), Hyderabad, Telangana, India.
    Background: Human immunodeficiency virus (HIV) pandemicity is a major concern today as it causes greater loss of productivity than any other disease. HIV infection leads to profound immune deficiency and patients become highly susceptible to opportunistic infections (OIs). HIV epidemic in India is heterogeneous in nature, both in terms of routes of transmission as well as geographical spread. Read More

    Whole genome sequencing analysis of the cutaneous pathogenic yeast Malassezia restricta and identification of the major lipase expressed on the scalp of patients with dandruff.
    Mycoses 2017 Mar 24;60(3):188-197. Epub 2016 Nov 24.
    Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea.
    Malassezia species are opportunistic pathogenic fungi that are frequently associated with seborrhoeic dermatitis, including dandruff. Most Malassezia species are lipid dependent, a property that is compensated by breaking down host sebum into fatty acids by lipases. In this study, we aimed to sequence and analyse the whole genome of Malassezia restricta KCTC 27527, a clinical isolate from a Korean patient with severe dandruff, to search for lipase orthologues and identify the lipase that is the most frequently expressed on the scalp of patients with dandruff. Read More

    Non-dermatophyte Dermatoses Mimicking Dermatophytoses in Animals.
    Mycopathologia 2017 Feb 16;182(1-2):113-126. Epub 2016 Nov 16.
    UP Interactions Cellules Environnement, VetAgro Sup, Univ Lyon, 69280, Marcy l'Etoile, France.
    Dermatophytoses in animals are fungal diseases of the skin caused by dermatophyte fungi of the genus Microsporum or Trichophyton. Because the infection is generally follicular, the most common clinical sign is one or many circular areas of alopecia with variable erythema, scaling and crusting, and the primary differential diagnoses are follicular infections, such as bacterial folliculitis and demodicosis. Although dermatophyte folliculitis or ringworm is the most commonly observed lesion of dermatophytoses in animals, other presentations may be observed according to the host species and the dermatophyte involved: dermatophyte folliculitis or ringworm, scaling and crusting in dermatophytosis due to Microsporum persicolor, nodule in case of kerion or mycetoma, matted hairs, seborrheic dermatosis or miliary dermatitis in cats, generalized exfoliative dermatoses in dogs, cats and horses, superficial non-follicular pustules, papules and macules in the Devon Rex cat, pruritic dermatophytoses in dogs, cats and horses, and onychomycosis in dogs, cats and horses. Read More

    Pityriasis amiantacea: a study of seven cases.
    An Bras Dermatol 2016 Sep-Oct;91(5):694-696
    Universidade Federal do Rio de Janeiro (UFRJ) - Rio de Janeiro (RJ), Brazil.
    Pityriasis amiantacea was first described in 1832. The disease may be secondary to any skin condition that primarily affects the scalp, including seborrheic dermatitis. Its pathogenesis remains uncertain. Read More

    Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review.
    Am J Clin Dermatol 2016 Nov 2. Epub 2016 Nov 2.
    Mediprobe Research Inc., 645 Windermere Road, London, ON, Canada.
    Background: Facial seborrheic dermatitis (SD), a chronic inflammatory skin condition, can impact quality of life, and relapses can be frequent. Three broad categories of agents are used to treat SD: antifungal agents, keratolytics, and corticosteroids. Topical therapies are the first line of defense in treating this condition. Read More

    Contact Alopecia: Improvement of Alopecia with Discontinuation of Fluocinolone Oil in Individuals Allergic to Balsam Fragrance.
    Pediatr Dermatol 2017 Jan 25;34(1):e57-e60. Epub 2016 Oct 25.
    Department of Dermatology, Loma Linda University, Loma Linda, California.
    Inflammatory scalp dermatoses can be associated with alopecia, which is nonscarring and reversible in its early stages. This association has been described in seborrheic dermatitis, psoriasis, and atopic dermatitis. We describe three girls with alopecia aggravated by contact allergy to balsam fragrances. Read More

    Low-dose oral isotretinoin for moderate to severe seborrhea and seborrheic dermatitis: a randomized comparative trial.
    Int J Dermatol 2017 Jan 25;56(1):80-85. Epub 2016 Oct 25.
    Department of Dermatology, Universidade Federal de São Paulo (Federal University of São Paulo [UNIFESP]), São Paulo, SP, Brazil.
    Background: The efficacy of low-dose oral isotretinoin in the treatment of seborrhea and seborrheic dermatitis has been poorly investigated in randomized studies.

    Objectives: This study was designed to determine the efficacy and safety of low-dose oral isotretinoin in the treatment of moderate to severe seborrhea and seborrheic dermatitis on the scalp and/or face.

    Methods: A randomized, comparative clinical trial, using two groups, was conducted over 6 months. Read More

    Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J).
    J Dermatol 2016 Oct 11. Epub 2016 Oct 11.
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA.
    Psoriasis, a chronic, immune-mediated skin disease characterized by red, scaly plaques, affects approximately 0.3% of the population in Japan. The aim of this open-label study was to evaluate the long-term efficacy and safety of ixekizumab, a humanized, anti-interleukin-17A monoclonal antibody, in Japanese patients with plaque psoriasis (n = 78, including 11 psoriatic arthritis), erythrodermic psoriasis (n = 8) and generalized pustular psoriasis (n = 5). Read More

    The role of topical anesthetics in the management of chronic pruritus.
    J Dermatolog Treat 2016 Sep 30:1-16. Epub 2016 Sep 30.
    a Department of Dermatology , Johns Hopkins University School of Medicine , Baltimore , MD , United States.
    Chronic itch is a debilitating symptom that significant decreases patients' quality of life. Topical corticosteroids and antihistamines are commonly used for itch. However, these therapies are not long-term solutions for chronic pruritus because of their feared side effects, including skin atrophy and cognitive impairment, respectively. Read More

    Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial.
    Dermatol Pract Concept 2016 Jul 31;6(3):11-6. Epub 2016 Jul 31.
    Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Few studies have examined the effect of seborrheic dermatitis (SD) and/or its consequent therapy on a patient's quality of life. Itraconazole has been suggested as an effective therapy for severe SD but its impact on Quality of Life (QoL) in these patients has never been studied before.

    Objective: The study aimed to verify the efficacy of the itraconazole on the quality of life in patients with moderate to severe SD. Read More

    Prospective Case Series of Cutaneous Adverse Effects Associated With Dabrafenib and Trametinib.
    J Cutan Med Surg 2016 Sep 13. Epub 2016 Sep 13.
    McGill University, Division Dermatology, Montréal, QC, Canada.
    Background: Dabrafenib, a novel selective small-molecule inhibitor of BRAF, has been shown to increase overall survival in patients with unresectable metastatic melanoma harboring the BRAF V600E mutation. The development of resistance has led to combination therapy with selective MEK inhibitor trametinib. Compared with vemurafenib, dabrafenib is a more recent BRAF inhibitor approved by the Food and Drug Administration in May 2013 for metastatic melanoma; fewer data are available in the current literature regarding cutaneous toxicity. Read More

    Dermoscopy in General Dermatology: A Practical Overview.
    Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

    Metabolic Syndrome in Childhood: Rare Case of Alstrom Syndrome with Blindness.
    Indian J Clin Biochem 2016 Oct 28;31(4):480-2. Epub 2015 Dec 28.
    Department of Pediatrics, Kasturba Medical College, Manipal University, Mangalore, India.
    Alstrom's syndrome (AS) is a rare autosomal recessive ciliopathic condition affecting 1:10,00,000 children. It's a single gene disorder of ALMS1 on chromosome 2 with multisystem involvement with cone-rod retinal dystrophy causing juvenile blindness, obesity, insulin resistance, type 2 Diabetes mellitus, hypogonadism and sensorineural hearing loss. Till now only 800 patients with this disorder has been identified so far. Read More

    Serum Biotin Levels in Women Complaining of Hair Loss.
    Int J Trichology 2016 Apr-Jun;8(2):73-7
    Center for Dermatology and Hair Diseases Professor Trüeb, Zurich-Wallisellen, Switzerland.
    Biotin is a coenzyme for carboxylase enzymes that assist various metabolic reactions involved in fatty acid synthesis, branched-chain amino acid catabolism, and gluconeogenesis important for maintenance of healthy skin and hair. Due to its availability, affordability, and effective marketing for this purpose, biotin is a popular nutritional supplement for treatment of hair loss. However, there are little data on the frequency of biotin deficiency in patients complaining of hair loss and on the value of oral biotin for treatment of hair loss that is not due to an inborn error of biotin metabolism or deficiency. Read More

    iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis.
    Arch Dermatol Res 2016 Nov 6;308(9):631-642. Epub 2016 Sep 6.
    L'Oreal Research and Innovation, 1 Avenue Eugène Schueller, 93600, Aulnay-Sous-Bois, France.
    The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological functions provided new insights into the affected metabolic pathways of a dandruff scalp. Read More

    Indole 3-acetic acid-photodynamic therapy in the treatment of multiple actinic keratoses: A proof of concept pilot study.
    Photodiagnosis Photodyn Ther 2016 Dec 23;16:17-22. Epub 2016 Aug 23.
    Department of Surgery and Translational Medicine, Division of Dermatology, University of Florence Medical School, Florence, Italy.
    Background: Actinic Keratoses (AK) are considered a form of in situ Squamous Cell Carcinoma (SCC) arising on chronically photoexposed skin. PDT with ALA or MAL is an effective treatment for multiple AK due its high Overall Response Ratio (ORR) but is burdened by important drawbacks: time-consumption, pain and high costs. Indole-3 acetic acid (IAA) is a newly described photosensitizer with proven clinical efficacy on seborrheic dermatitis and acne vulgaris. Read More

    Prevalence and related factors of psoriasis and seborrheic dermatitis: a community-based study.
    Turk J Med Sci 2016 Feb 17;46(2):303-9. Epub 2016 Feb 17.
    Department of Internal Medicine, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
    Background/aim: We aimed to determine the prevalence of psoriasis (PS) and seborrheic dermatitis (SD) (erythematous-squamous diseases) in our region and reveal the frequently encountered associated factors to aid in planning appropriate healthcare.

    Materials And Methods: A community-based study was conducted with 85 sample groups that reflected the population rate and demography of Tokat Province in northern Anatolia.

    Results: In this community, the prevalence of PS in people older than 20 years of age was 1. Read More

    Inframammary Dermatitis: A Case of Localized Late-Onset Darier's Disease.
    Case Rep Dermatol 2016 May-Aug;8(2):189-92. Epub 2016 Jul 12.
    Rare Diseases and Periodic Fevers Research Centre, Department of Internal Medicine, Rome, Italy.
    Darier's disease (DD) is an autosomal dominant inherited genodermatosis which is often under- or misdiagnosed. In the majority of cases, the disease manifests in adolescents or young adults with small brownish-yellow, warty, hyperkeratotic papules in multiple seborrheic areas of the body. Localized DD (LDD) is a clinical variant, first described by Kreibich in 1906; only a few cases are reported in the literature. Read More

    β-Endorphin enhances the phospholipase activity of the dandruff causing fungi Malassezia globosa and Malassezia restricta.
    Med Mycol 2017 Feb 5;55(2):150-154. Epub 2016 Aug 5.
    Mycology Division, Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    β-Endorphin is known to stimulate phospholipase production by Malassezia pachydermatis during canine dermatoses. The role of β-endorphin in Malassezia infection in humans is not well studied. The present study compares the influence of β-endorphin on Malassezia globosa and Malassezia restricta isolated from patients with seborrhoeic dermatitis/dandruff (SD/D) and healthy controls. Read More

    Histopathological Differential Diagnosis of Psoriasis and Seborrheic Dermatitis of the Scalp.
    Ann Dermatol 2016 Aug 26;28(4):427-32. Epub 2016 Jul 26.
    Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
    Background: The differential diagnosis of psoriasis and seborrheic dermatitis can be difficult when both conditions are localized to the scalp without the involvement of other skin sites.

    Objective: We aimed to evaluate the histopathological differences between psoriasis and seborrheic dermatitis on the scalp and identify favorable criteria for their differential diagnosis.

    Methods: We evaluated 15 cases of psoriasis and 20 cases of seborrheic dermatitis of the scalp that had been clinicopathologically diagnosed. Read More

    Treatment of Seborrhoeic Dermatitis in Asia: A Consensus Guide.
    Skin Appendage Disord 2016 May 23;1(4):187-96. Epub 2016 Mar 23.
    Dermatology Clinic, University of Catania, Catania, Italy.
    Seborrhoeic dermatitis (SD) is common in Asia. Its prevalence is estimated to be 1-5% in adults. However, larger population-based studies into the epidemiology of SD in Asia are lacking, and the aetiology of SD may differ widely from Western countries and in different parts of Asia. Read More

    A highly sensitive LC-MS/MS method for determination of ketoconazole in human plasma: Application to a clinical study of the exposure to ketoconazole in patients after topical administration.
    J Pharm Biomed Anal 2016 Sep 19;128:504-9. Epub 2016 Jun 19.
    Department of Pharmaceutical Analysis, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Electronic address:
    A simple, rapid and highly sensitive LC-MS/MS method was developed and validated for the determination of ketoconazole in human plasma. Sample preparation was accomplished through a single step liquid-liquid extraction by ethyl acetate. The chromatography separation was carried out on a Hedera CN (150mm×2. Read More

    Low DNA Sequence Diversity of the Intergenic Spacer 1 Region in the Human Skin Commensal Fungi Malassezia sympodialis and M. dermatis Isolated from Patients with Malassezia-Associated Skin Diseases and Healthy Subjects.
    Mycopathologia 2016 Dec 1;181(11-12):839-842. Epub 2016 Jul 1.
    Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan.
    As DNA sequences of the intergenic spacer (IGS) region in the rRNA gene show remarkable intraspecies diversity compared with the small subunit, large subunit, and internal transcribed spacer region, the IGS region has been used as an epidemiological tool in studies on Malassezia globosa and M. restricta, which are responsible for the exacerbation of atopic dermatitis (AD) and seborrheic dermatitis (SD). However, the IGS regions of M. Read More

    Comprehensive pyrosequencing analysis of the bacterial microbiota of the skin of patients with seborrheic dermatitis.
    Microbiol Immunol 2016 Aug;60(8):521-6
    Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588.
    Seborrheic dermatitis (SD) is a chronic inflammatory dermatologic condition in which erythema and itching develop on areas of the body with sebaceous glands, such as the scalp, face and chest. The inflammation is evoked directly by oleic acid, which is hydrolyzed from sebum by lipases secreted by skin microorganisms. Although the skin fungal genus, Malassezia, is thought to be the causative agent of SD, analysis of the bacterial microbiota of skin samples of patients with SD is necessary to clarify any association with Malassezia because the skin microbiota comprises diverse bacterial and fungal genera. Read More

    Analysis of Dermatologic Diseases in Neurosurgical In-Patients: A Retrospective Study of 463 Cases.
    Ann Dermatol 2016 Jun 25;28(3):314-20. Epub 2016 May 25.
    Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Background: Both the skin and the neurologic system are derived from the ectoderm during embryogenesis, and thus patients with neurologic disorders may have accompanying dermatologic diseases. For example, seborrheic dermatitis is more frequently observed in patients with Parkinsonism and other neurologic disorders. To date, however, there has been limited review on dermatologic diseases in neurosurgical in-patients. Read More

    Evaluation of cutaneous surface parameters in psoriatic patients.
    Skin Res Technol 2017 Feb 8;23(1):41-47. Epub 2016 Jun 8.
    Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy.
    Purpose: The purpose of this study was to compare cutaneous surface parameters in lesional and non-lesional skin of psoriatic patients and in corresponding areas of control subjects.

    Methods: Sixty-six psoriatic patients (of any grade of severity, with or without arthritis, without any therapy other than systemic biologic drugs) and 28 healthy controls were enrolled in this observational, case-control study. Exclusion criteria were current or past sebo-psoriasis and seborrheic dermatitis, pustular or erithrodermic psoriasis; treatment with immune-suppressive agents, retinoids, or ultraviolet phototherapy in the last 6 months; topical treatment in the last 2 weeks. Read More

    Dermatologic emergencies in a tertiary hospital: A descriptive study.
    Actas Dermosifiliogr 2016 Oct 26;107(8):666-73. Epub 2016 May 26.
    Departamento de Dermatología, Hospital Universitario de Salamanca, Salamanca, España; Instituto de Biología Molecular y Celular del Cáncer (IBMCC), Centro de Investigación del Cáncer (CIC), Salamanca, España.
    Background And Objective: Dermatology in-house call is uncommon in the Spanish national health system. The objective of the present study was to define the groups of dermatologic diseases and conditions most frequently seen in the emergency department and to evaluate the need for dermatology in-house call in the training of medical residents.

    Material And Methods: We performed a descriptive study of all patients who attended the emergency department with a skin complaint during a 1-year period (June 2013 to May 2014) and were assessed by 9 dermatology residents. Read More

    Physiological and microbiological verification of the benefit of hair washing in patients with skin conditions of the scalp.
    J Cosmet Dermatol 2016 Dec 26;15(4):e1-e8. Epub 2016 May 26.
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan.
    Background: It is unclear whether hair washing is effective against scalp eruption and pruritus caused by seborrheic dermatitis or psoriasis vulgaris.

    Aims: To assess whether a proper hair-washing regimen, including the use of antibacterial shampoo, can ameliorate scalp eruption symptoms and alter the composition of the scalp microflora.

    Methods: Eighteen patients with seborrheic dermatitis or psoriasis vulgaris scalp eruptions were instructed in proper techniques of daily hair washing, rinsing, and shampooing, which they underwent for 12 weeks. Read More

    Off-Label Uses of Topical Calcineurin Inhibitors.
    Skin Therapy Lett 2016 Jan;21(1):8-10
    Division of Dermatology & Cutaneous Sciences, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
    Topical calcineurin inhibitors (TCIs) have been proposed as an alternative, long-term treatment option to topical corticosteroids, without the side effects commonly associated with steroid use. Currently, TCIs are only approved for treatment of atopic dermatitis in patients 2 years of age or older. This article reviews the off-label uses of TCIs and their efficacy in the treatment of cutaneous diseases. Read More

    Superficial Mycoses Associated with Diaper Dermatitis.
    Mycopathologia 2016 Oct 19;181(9-10):671-9. Epub 2016 May 19.
    Department of Mycology and Dermatology Service, Hospital General de México, "Dr. Eduardo Liceaga", Dr. Balmis 148, Col Doctores, CP 06720, Mexico, DF, Mexico.
    Diapers create particular conditions of moisture and friction, and with urine and feces come increased pH and irritating enzymes (lipases and proteases). Fungi can take advantage of all these factors. Candida yeasts, especially C. Read More

    Noncorticosteroid Combination Shampoo versus 1% Ketoconazole Shampoo for the Management of Mild-to-Moderate Seborrheic Dermatitis of the Scalp: Results from a Randomized, Investigator-Single-Blind Trial Using Clinical and Trichoscopic Evaluation.
    Skin Appendage Disord 2016 Feb 17;1(3):126-30. Epub 2015 Oct 17.
    Dermatology Clinic, University of Catania, Catania, Italy.
    Purpose: The aim of this study was to assess the efficacy and tolerability of a combination noncorticosteroid, antiinflammatory/antifungal shampoo versus 1% ketoconazole shampoo in the treatment of mild-to-moderate scalp seborrheic dermatitis (SD).

    Procedures: Twenty patients were randomized to using the combination shampoo (group A, 10 patients) or the 1% ketoconazole shampoo (group B, 10 patients) 3 times a week every other day for 8 weeks. Efficacy was evaluated by measuring the degree of scaling and pruritus by clinical and trichoscopic examination using a 4-point scale. Read More

    Meyerson Phenomenon as a Component of Melanoma in situ.
    Acta Dermatovenerol Croat 2016 Apr;24(1):81-2
    Engin Sezer, MD, Acıbadem University School of Medicine, Department of Dermatology, Buyukdere Caddesi No: 40, Istanbul, Turkey;
    Meyerson phenomenon (MP) is characterized by a symmetrical area of erythema and scales encircling a central lesion, which is most commonly a banal melanocytic nevus. Herein, we describe an unusual case with MP representing an eczematized response to a melanoma in situ and review the literature covering this entity. A 56-year-old man presented with a 6-month history of a pruritic, pigmented lesion on the trunk. Read More

    Erlotinib-induced Rosacea-like Dermatitis.
    Acta Dermatovenerol Croat 2016 Apr;24(1):65-9
    Saida Rezaković, MD "Sunce" Polyclinic - Polyclinic for Internal Medicine, Neurology, Urology, Physical medicine, Occupational Medicine, , Orthopedics, Psychiatry, Gynecology, Ophthalmology, Dermatovenerology, Otorhinolaryngology, Cytology and Radiology,, Trnjanska cesta 108, 10 000 Zagreb, Croatia;
    Skin and skin adnexa toxicities are the most common side effects associated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and occur in most patients receiving this therapy. The majority of these cutaneous side effects are transient, reversible, and dose dependent. Although these symptoms are in general not severe, they significantly affect quality of life and can have a serious effect on treatment compliance as well as the treatment regimen. Read More

    Seborrheic Dermatitis and Dandruff: A Comprehensive Review.
    J Clin Investig Dermatol 2015 Dec 15;3(2). Epub 2015 Dec 15.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB 2023A, Miami, Florida 33136, USA.
    Seborrheic Dermatitis (SD) and dandruff are of a continuous spectrum of the same disease that affects the seborrheic areas of the body. Dandruff is restricted to the scalp, and involves itchy, flaking skin without visible inflammation. SD can affect the scalp as well as other seborrheic areas, and involves itchy and flaking or scaling skin, inflammation and pruritus. Read More

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