Pol J Vet Sci 2017 Mar;20(1):141-147

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Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Read More

Acta Derm Venereol 2017 May 12. Epub 2017 May 12.

Department of Dermatology, No.1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China.

Surg Pathol Clin 2017 Jun;10(2):367-382

Department of Dermatology, University of Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany; Labor für Dermatohistologie und Oralpathologie, Bayerstrasse 69, 80335 München, Munich, Germany. Electronic address:

Sebaceous skin tumors are classified into sebaceous adenoma, sebaceoma, and sebaceous carcinoma. An additional group of cystic sebaceous tumors indicate the Muir-Torre syndrome (MTS). Cystic sebaceous tumors are considered as morphologic variants of the 3 main categories. Read More

J Drugs Dermatol 2017 Apr;16(4):329-331

N Z Vet J 2017 Jul 20;65(4):219-223. Epub 2017 Apr 20.

d New Zealand Veterinary Pathology Ltd , Palmerston North , New Zealand.

CASE HISTORY AND CLINICAL FINDINGS A 15-year-old neutered male domestic short-haired cat was presented due to multiple 0.5-2 cm-diameter crusting plaques in the left preauricular region, over the bridge of nose, and in the right periocular region. The plaques did not appear to cause discomfort. Read More

Nagoya J Med Sci 2017 Feb;79(1):85-90

Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

A 65-year-old man was referred to our hospital for the treatment of a lesion on the medial lacrimal canthus of both eyes. He had a history of perinuclear anti-neutrophil cytoplasmic antibodies, i.e. Read More

J Cutan Med Surg 2016 Dec 1:1203475416685076. Epub 2016 Dec 1.

1 Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Dermatology, Ankara, Turkey.

Background: Cryosurgery is an effective treatment for sebaceous hyperplasia, but there have been few clinical studies.

Objectives: The aim of this study was to evaluate the efficacy and safety of cryosurgery in the treatment of sebaceous hyperplasia.

Methods: Cryosurgery was performed 6 times, at 2-week intervals, with liquid nitrogen, and evaluated in 40 patients with 517 lesions ranging from 2 to 9 mm over the forehead, cheeks, and chin. Read More

J Dermatol 2017 May 3;44(5):548-549. Epub 2017 Mar 3.

Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

Skin Appendage Disord 2017 Jan 8;2(3-4):166-176. Epub 2016 Dec 8.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. Read More

Indian J Dermatol Venereol Leprol 2017 Mar-Apr;83(2):213-216

Department of Pathology, North Bengal Medical College and Hospital, Darjeeling, West Bengal, India.

J Cutan Pathol 2017 Apr 27;44(4):352-357. Epub 2017 Jan 27.

Hôpital Saint-Louis, Centre Sabouraud, Paris, France.

Background: Follicular hyperkeratosis along with hyperplasia of the follicular and interfollicular epithelia are major histopathological characteristics of hidradenitis suppurativa (HS). The presence of an occasional thickening of lesional skin in some folliculitis decalvans (FD) patients and histological similarities between FD and HS led us to look for epidermal hyperplasia and follicular hyperkeratosis in FD patients.

Patients And Method: We performed a retrospective histological analysis of 26 patients with FD. Read More

Am J Dermatopathol 2016 Dec 23. Epub 2016 Dec 23.

*Department of Diagnostic Pathology, Kainan Hospital, Aichi, Japan;†Department of Pathology and Cytology, Karolinska University Hospital, Huddinge, Sweden;‡Sapporo Dermatopathology Institute, Sapporo, Japan;§Fukumoto Dermatopathology Clinic, Nara, Japan; and¶Division of Dermatology, Nakao Clinic, Saga, Japan.

This study investigated the nature of carcinoid-like, labyrinthine, rippled, and conventional cell arrangements in sebaceous neoplasms, focusing on vimentin expression and Merkel cell distribution in sebaceous neoplasms relative to these findings in normal sebaceous units and other sebaceous conditions. Immunohistochemistry for vimentin and cytokeratin 20 (CK20) was evaluated in carcinoid-like (n = 2), labyrinthine (n = 4), rippled (n = 3), and conventional (n = 6) sebaceomas; sebaceous mantle hyperplasia (n = 1); steatocystomas (n = 5); fibrofolliculomas (n = 4); sebaceous mantleoma (n = 1); sebaceous gland hyperplasias (n = 4); sebaceous adenomas (n = 4); and sebaceous carcinomas (n = 4) as well as normal skin tissue. The sebaceous mantle and its hamartoma (fibrofolliculoma) showed weak positivity for vimentin in the basal layer of the epithelial component and contained a few CK20-positive Merkel cells within the epithelial component, whereas mature sebaceous lobules were negative for vimentin and did not contain any Merkel cells. Read More

J Dermatol 2016 Dec 27. Epub 2016 Dec 27.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

Rhinophyma results from hyperplasia of the sebaceous glands and connective tissue. Clinical features in Asian rhinophyma patients are largely underreported. In this study, we aimed to evaluate the clinical features of rhinophyma in Korean patients. Read More

Dermatopathology (Basel) 2016 Oct-Dec;3(4):79-82. Epub 2016 Nov 12.

Division of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland.

Many cutaneous complications have been described in patients treated with cyclosporin. Alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent. However, the occurrence of sebaceous hyperplasia is exceptional. Read More

J Pediatr (Rio J) 2017 May - Jun;93(3):238-245. Epub 2016 Nov 19.

Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-graduação em Saúde da Criança e Adolescente, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre (HCPA), Departamento de Dermatologia, Porto Alegre, RS, Brazil.

Objective: To determine the prevalence of neonatal dermatological findings and analyze whether there is an association between these findings and neonatal and pregnancy characteristics and seasonality.

Methods: Newborns from three maternity hospitals in a Brazilian capital city were randomly selected to undergo dermatological assessment by dermatologists.

Results: 2938 neonates aged up to three days of life were randomly selected, of whom 309 were excluded due to Intensive Care Unit admission. Read More

Clin Exp Dermatol 2016 Dec 19;41(8):923-924. Epub 2016 Oct 19.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Wien Med Wochenschr 2016 Nov 10. Epub 2016 Nov 10.

Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Università Degli Studi "G. Marconi", Rome, Italy.

Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Read More

G Ital Dermatol Venereol 2016 Dec;151(6):721-726

Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China -

Ophthal Plast Reconstr Surg 2016 Nov 2. Epub 2016 Nov 2.

*Ocular Oncology Service and †Department of Ophthalmic Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.

Introduction: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid.

Objective: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. Read More

Ophthal Plast Reconstr Surg 2016 Oct 11. Epub 2016 Oct 11.

*Division of Oculoplastic and Orbit, Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery; and †Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Pachydermoperiostosis is a rare genetic disease that causes major bone and skin changes. Severe ptosis is a prominent finding in this peculiar condition. We report here 2 patients with typical features of pachydermoperiostosis. Read More

Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.

SUNY Downstate Medical Center; New York Harbor Healthcare System; Mount Sinai Medical Center.

Non-invasive imaging devices are currently being utilized in research and clinical settings to help visualize, characterize, anddiagnose cancers of the skin. Speckle-variance optical coherence tomography (svOCT) is one such technology that offers considerable promise for non-invasive, real time detection of skin cancers given its added ability to show changes in microvasculature. We present four early lesions of the face namely sebaceous hyperplasia, basal cell skin cancer, pigmented actinic keratosis, and malignant melanoma in situ that each display different important identification markers on svOCT. Read More

G Ital Dermatol Venereol 2016 Sep 6. Epub 2016 Sep 6.

Clinica Dermatologica, La Sapienza University of Rome, Rome, Italy -

Pathologists who find ectopic glands on the glans and/or on the prepuce, often describe them as Tyson's glands. In this regard, the term Tyson's glands can be replaced by two different descriptive expressions: papillomatosis corona penis and ectopic sebaceous glands. A 15-year old Caucasian male patient presented to our Institute with multiple and asymptomatic circular skin colored-to-yellowish papules at the level of the foreskin, also affecting the shaft of the penis, where they assumed a linear feature. Read More

Eye Contact Lens 2016 Jul 12. Epub 2016 Jul 12.

Department of Ophthalmology (M.O., M.S., M.D., J.S.), Tokyo Dental College Ichikawa General Hospital, Chiba, Japan; Department of Ophthalmology (M.O., M.D., K.T.), Keio University School of Medicine, Tokyo, Japan; Department of Ophthalmology (M.S.), Fukushima University School of Medicine, Fukushima, Japan; Department of Pathology and Laboratory Medicine (J.M., Y.T.), Tokyo Dental College Ichikawa General Hospital, Chiba, Japan; and Department of Ophthalmology (H.O.), Jichi Medical University, Saitama, Japan.

Purpose: To report the clinical and histopathological features of two patients with caruncular and pericaruncular sebaceous gland hyperplasia (SGH) with a literature review.

Methods: We performed a retrospective pathology database search of 1195 ophthalmic specimens receiving the clinical diagnosis of SGH for caruncular/pericaruncular lesions during 2004 to 2014 at Tokyo Dental College, Ichikawa General Hospital. Paraffin sections were stained with hematoxylin and eosin. Read More

Dermatopathology (Basel) 2016 Apr-Jun;3(2):44-54. Epub 2016 Jun 1.

Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.

Background: Sebaceous glands contribute significantly to the barrier functions of the skin. However, little is known about their homeostasis and tumorigenesis. Recently, increased expression of stem cell marker Lrig1 has been reported in sebaceous carcinoma-like tumors of K14ΔNLef1 transgenic mice. Read More

Ann N Y Acad Sci 2016 Aug 2;1378(1):118-123. Epub 2016 Jul 2.

Department of Environmental Science, New York Medical College, Valhalla, New York.

In mouse skin, sulfur mustard (SM) is a potent vesicant, damaging both the epidermis and the dermis. The extent of wounding is dependent on the dose of SM and the duration of exposure. Initial responses include erythema, pruritus, edema, and xerosis; this is followed by an accumulation of inflammatory leukocytes in the tissue, activation of mast cells, and the release of mediators, including proinflammatory cytokines and bioactive lipids. Read More

J Invest Dermatol 2016 Sep 14;136(9):1792-800. Epub 2016 Jun 14.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:

In a transcriptome study of lesional psoriatic skin (PP) versus normal skin, we found a coexpressed gene module (N5) enriched 11.5-fold for lipid biosynthetic genes. We also observed fewer visible hairs in PP skin, compared with uninvolved nonlesional psoriatic skin or normal skin (P < 0. Read More

Am J Rhinol Allergy 2016 May;30(3):83-90

Otorhinolaryngology and Head and Neck Surgery Clinic, Bakirkoy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey.

Objectives: The goal of this study was to review the main lesion types of the nasal skin and appropriate treatment strategies rather than to present a comprehensive list of all diseases that affect the skin that can involve the nose.

Methods: We reviewed the main nasal skin lesion types and available treatment strategies. Nasal skin lesions were classified as benign, premalignant, or malignant. Read More

Am J Otolaryngol 2016 May-Jun;37(3):251-4. Epub 2016 Jan 22.

Reina Sofía University Hospital, Córdoba, Spain.

Background: Phymatous rosacea is characterized by thickened skin and irregular surface contours as the result of variable combinations of fibrosis, sebaceous hyperplasia and lymphoedema. Otic phyma is rarely seen and has been rarely reported in the English literature.

Methods: We present another case of this uncommon condition, frequently misdiagnosed, maybe due to its underrecognition. Read More

J Cutan Pathol 2016 Aug 14;43(8):657-62. Epub 2016 Jun 14.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Background: Sebaceous proliferations are common and may be confused with other cutaneous neoplasms. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. We incidentally observed strong factor XIIIa (Ventana clone AC-1A1 on Ventana Benchmark Ultra stainer) nuclear staining in normal sebaceous glands and hypothesized that this might be a useful marker in sebaceous proliferations. Read More

J Cutan Pathol 2016 Aug 10;43(8):649-56. Epub 2016 Jun 10.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Sebaceous carcinoma is a rare but serious malignancy that may be difficult to diagnose when poorly differentiated. Other epithelial tumors with clear cell change may mimic sebaceous carcinoma. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. Read More

J Dermatol 2016 Oct;43(10):1205-1208

Department of Dermatology, Cathay General Hospital, Taipei City, Taiwan.

Presenile diffuse familial sebaceous hyperplasia (PDFSH) presents as extensive yellowish papules with central umbilication on the face without involvement of periorificial regions and occurs in adolescents or young adults with a positive family history. Thirteen cases of PDFSH have been reported in the English-language published work, 10 of which responded to oral isotretinoin from 0.5 to 1 mg/kg per day but recurrences were often observed. Read More

Ann Dermatol 2016 Apr 31;28(2):271-2. Epub 2016 Mar 31.

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Eur J Dermatol 2016 Jun;26(3):299-300

Department of Pathology, University of Medicine Targu Mures, Romania.

Dermatol Online J 2016 Jan 15;22(1). Epub 2016 Jan 15.

University of California Davis Medical Center, Sacramento.

Cyclosporine-induced sebaceous hyperplasia (SH) is a well-documented entity, occurring in up to 30% of renal transplant patients treated with cyclosporine and has also been reported to occur following heart or hematopoetic stem cell transplantation (HCST). Cyclosporine has a stimulatory effect on undifferentiated sebocytes, resulting in the clinical and histologic findings in these patients. Sebaceous hyperplasia most commonly presents as asymptomatic papules over the face, chest, or groin. Read More

Case Rep Dermatol 2015 Sep-Dec;7(3):358-62. Epub 2015 Dec 23.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

We herein report a case of hair follicle nevus, a rare hamartoma found on the face and showing follicular differentiation, which was associated with sebaceous hyperplasia. Dermoscopy of the lesion showed yellow globules surrounded by crown vessels/telangiectasias and scattered tiny hairs. Histopathological investigation revealed hyperplasia of the sebaceous glands and proliferation of well-differentiated vellus hair follicles. Read More

MMW Fortschr Med 2015 Nov;157 Spec No 2

Pan Afr Med J 2015 22;22:177. Epub 2015 Oct 22.

Service de Dermatologie, Vénérologie, Hôpital Ibn Sina, Rabat, Maroc.

Int J Trichology 2015 Oct-Dec;7(4):170-2

Department of Dermatology and Venereology, Pramukshwami Medical College, Karamsad, Gujarat, India.

Sebaceous hyperplasia (SH), a common, benign condition of sebaceous gland, presents most commonly over face. Lesions are usually described as asymptomatic, soft, discrete, and yellow with a surface that ranges from smooth to slightly verrucous. The pathogenesis is not fully understood. Read More

World J Gastroenterol 2016 Feb;22(7):2349-56

Ming-Wun Wong, Ming-Joug Bair, Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taitung 950, Taiwan.

Aim: To better understand some of the superficial tiny lesions that are recognized as squamous papilloma of the esophagus (SPE) and receive a different pathological diagnosis.

Methods: All consecutive patients with esophageal polypoid lesions detected by routine endoscopy at our Endoscopy Centre between October 2009 and June 2014 were retrospectively analysed. We enrolled patients with SPE or other superficial lesions to investigate four key endoscopic appearances (whitish color, exophytic growth, wart-like shape, and surface vessels) and used narrow band imaging (NBI) to distinguish their differences. Read More

Dermatology 2016 12;232(2):220-3. Epub 2016 Feb 12.

Referral Center for Autoimmune and Toxic Bullous Diseases, Dermatology Department, Hx00F4;pitaux Universitaires Henri-Mondor, Universitx00E9; Paris-Est Crx00E9;teil, Crx00E9;teil, France.

Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse drug reaction leading to extensive sloughing of the skin. Late cutaneous complications such as pigmentation disorders are frequently reported. In this report, we present particular facial cutaneous sequelae with histological analysis after TEN. Read More

Acta Derm Venereol 2016 Aug;96(6):737-41

Department of Dermatology, University of Regensburg, DE-93053 Regensburg, Germany.

Sporadic sebaceous gland hyperplasia (SGH) is a benign skin lesion, with a high prevalence in the general population. Although SGH has been attributed to both extrinsic and intrinsic factors, the underlying genetic changes have not yet been characterized. Recently, HRAS and KRAS mutations have been identified in sebaceous naevus, a hamartoma sharing histological characteristics with SGH. Read More

Arch Dis Child Fetal Neonatal Ed 2016 May 19;101(3):F252. Epub 2016 Jan 19.

Department of Dermatology, Indira Gandhi Medical College and Research Institute (IGMC&RI), Pondicherry, India.

Indian J Dermatol Venereol Leprol 2016 Jan-Feb;82(1):113

Department of Dermatology, Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan; Department of Dermatology, Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China.

Dermatol Online J 2016 Dec 15;22(12). Epub 2016 Dec 15.

Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.

Diffuse sebaceous-gland hyperplasia is a rarevariant of sebaceous-gland hyperplasia that isdistinct from the well-known circumscribed type.The term presenile sebaceous hyperplasia has beenutilized to describe this entity that is distinguishedby specific features, which include confluence oflesions that results in the formation of large plaqueson the face, the sparing of periorificial regions, andhighly functional glandular hyperplasia that resultsin excessive sebaceous secretion. We present a43-year-old woman with monomorphous, skincoloredand yellow, smooth 1- to-3-mm papules,some with central umbilication, that spare theperiorificial zones. Read More

Handb Clin Neurol 2015 ;132:9-25

Departments of Paediatrics, Pathology (Neuropathology) and Clinical Neurosciences, Calgary, Alberta, Canada.

Epidermal nevus syndrome (ENS) is a term that encompasses several phenotypes defined by the association of an epidermal nevus with one or more congenital systemic anomalies, mainly ocular, osseous and cerebral. The two most frequent, keratinocytic nevus syndrome and linear sebaceous nevus syndrome, also correspond to the neurological phenotypes. They both exhibit overlapping and distinctive features but same etiology: post-zygotic mosaic mutations in RAS genes. Read More

Exp Dermatol 2016 Mar 12;25(3):187-93. Epub 2016 Jan 12.

Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.

To explore the role of amphiregulin in inflammatory epidermal hyperplasia, we overexpressed human AREG (hAREG) in FVB/N mice using a bovine K5 promoter. A construct containing AREG coding sequences flanked by 5' and 3' untranslated region sequences (AREG-UTR) led to a >10-fold increase in hAREG expression compared to an otherwise-identical construct containing only the coding region (AREG-CDR). AREG-UTR mice developed tousled, greasy fur as well as elongated nails and thickened, erythematous tail skin. Read More

Dent Update 2015 Jul-Aug;42(6):520-2, 524

Facial skin lesions are common; patients may present with a.nodule, crack, ulcer or abnormal discoloration of the skin that is not normally present. Ideally, dentists should include face examination in their routine clinical examination. Read More

Am Fam Physician 2015 Oct;92(7):601-7

Naval Hospital Jacksonville, Jacksonville, FL, USA.

Patients will experience a wide range of skin growths and changes over their lifetime. Family physicians should be able to distinguish potentially malignant from benign skin tumors. Most lesions can be diagnosed on the basis of history and clinical examination. Read More

Ann Dermatol Venereol 2015 Nov 14;142(11):646-52. Epub 2015 Sep 14.

Service de dermatologie, CHR d'Orléans, 1, rue Porte-Madeleine, 45032 Orléans, France.

Background: Clinical differential diagnosis between incipient nodular basal carcinoma (NBC) and sebaceous hyperplasia (SH) of the face is difficult in some cases. A comparative histological analysis of these two entities led us to the hypothesis that 20MHz high-resolution ultrasonography (HRUS) may enable differentiation between NBC and SH.

Patients And Methods: Seventy-seven facial tumours requiring histological confirmation to distinguish between NBC and SH were scanned using HRUS before excision. Read More

Int J Dermatol 2016 Feb 17;55(2):193-200. Epub 2015 Sep 17.

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nevus sebaceus is a hamartoma composed of abnormal epidermal and dermal components with clinical and histopathological features that change with aging. Prophylactic excision of the lesion was advised historically considering its potential for giving rise to malignant tumors. However, whether early prophylactic excision should be performed has been questioned recently as most of the tumors have been found to be benign in origin. Read More