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    640 results match your criteria Sebaceous Hyperplasia

    1 OF 13

    Primary cutaneous ganglioneuroma: anatomoclinical study of 4 cases with focus on Merkel cells.
    J Cutan Pathol 2018 Mar 22. Epub 2018 Mar 22.
    Department of Dermatopathology and Dermatology, Faculty of Medicine, University Hospital of Strasbourg, University of Strasbourg, Strasbourg, France.
    Cutaneous ganglioneuromas (CGNs) are exceptional. We aim to describe the anatomoclinical profile of primary CGN and report 4 cases. Patients were 2 men and 2 women aged 53 to 76 years, who had flesh-colored nodules on the back, associated with adjacent keratotic changes, that is, epidermal nevus (1 case) or seborrheic keratosis (3 cases). Read More

    Use of the microdebrider in the surgical management of rhinophyma.
    Ear Nose Throat J 2018 Jan-Feb;97(1-2):E42-E45
    Department of Otolaryngology-Head and Neck Surgery, University of Ottawa Faculty of Medicine, Ottawa, Ont., Canada.
    Rhinophyma is a disfiguring end-stage manifestation of acne rosacea. It is characterized by a painless hyperplasia of the sebaceous glands and connective tissues of the nose. Numerous surgical modalities-including scalpel surgery, dermabrasion, CO laser ablation, and electrocautery-have been reported with varying results. Read More

    Clinical and histopathological characteristics in patients with scarring folliculitis type of acne inversa.
    Dermatoendocrinol 2017 4;9(1):e1361575. Epub 2017 Oct 4.
    Department of Dermatology, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China.
    : This study was designed to study the clinical and histopathological characteristics of patients with the scarring folliculitis type acne inversa in Chinese population. : A total of 21 patients with acne inversa and 6 controls without known dermatological disease were recruited from outpatient department of dermatology and orthopedic surgery. Two-millimeter punch biopsies were taken from 8 patients with acne inversa and 6 controls, fixed in formalin, embedded in paraffin and stained with haematoxylin and eosin prior to histopathological analysis. Read More

    Phacomatosis pigmentokeratotica: a case of HRAS mosaicism causing rhabdomyosarcoma.
    Br J Dermatol 2018 Feb 12. Epub 2018 Feb 12.
    Departments of Pathology, Hospital Universitario 12 de Octubre, I+12 Research Institute, Universidad Complutense, Madrid, Spain.
    A 17-year-old male presented with a large sebaceous naevus (SN) comprising part of his left face and scalp and a speckled lentiginous naevus (SLN) on his right trunk, hip, neck and scalp with a checkerboard pattern. His right oral hemimucosa showed extensive papillomatous lesions which were contiguous to the upper lip SN lesions. As for extracutaneous manifestations he suffered from cardiac, musculoskeletal and ocular alterations. Read More

    Indications and Use of Isotretinoin in Facial Plastic Surgery.
    Facial Plast Surg 2018 Feb 6;34(1):75-81. Epub 2018 Feb 6.
    Skin and Face Clinic, Baden-Baden, Germany.
    Isotretinoin is a first generation retinoid with pleiotropic effects on keratinocyte differentiation, proliferation, and activity of sebaceous glands. For years, there has been intense debate on whether the use of isotretinoin combined with cosmetic or surgical procedures is safe and potentially more efficient than either therapy alone. Due to delays in wound healing and keloid formation, conservative recommendations were not to combine isotretinoin with any plastic surgery or local treatment at 6 to 12 months after discontinuation of the drug. Read More

    Eruptive Sebaceous Hyperplasia: A Rare Consequence of Systemic Corticosteroids.
    J Drugs Dermatol 2018 Jan;17(1):118-120
    Background: Eruptive sebaceous hyperplasia is a rare and poorly understood consequence of immunosuppression, most commonly with cyclosporine, following organ transplantation. To date, there have been no reports documenting eruptive sebaceous hyperplasia associated with the utilization of immunosuppression outside of this clinical scenario.

    Observation: A 43-year-old Caucasian male with a significant history for Crohn's disease presented with the sudden appearance of multiple asymptomatic growths now present for several weeks. Read More

    Histopathology, microbiology and the inflammatory process associated with Sarcoptes scabiei infection in the Iberian ibex, Capra pyrenaica.
    Parasit Vectors 2017 Dec 4;10(1):596. Epub 2017 Dec 4.
    Servei d'Ecopatologia de Fauna Salvatge (SEFaS), Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona (UAB), E-08193 Bellaterra, Barcelona, Spain.
    Background: Sarcoptic mange has been identified as the most significant infectious disease affecting the Iberian ibex (Capra pyrenaica). Despite several studies on the effects of mange on ibex, the pathological and clinical picture derived from sarcoptic mange infestation is still poorly understood. To further knowledge of sarcoptic mange pathology, samples from ibex were evaluated from histological, microbiological and serological perspectives. Read More

    Fibroepithelial Polyp with Sebaceous Hyperplasia: A Case Report.
    Indian J Med Paediatr Oncol 2017 Jul-Sep;38(3):404-406
    Private Practitioner, New Delhi, India.
    Fibro epithelial Polyp (FEP) is a polypoid outgrowth of epidermis and dermal fibro vascular tissue. This polyp is most commonly found in oral cavity, neck and axilla, though any skin fold may be affected like groin area. We describe a case of a 25-year-old male patient with a growth over the anterior rugae region of hard palate since 3 years. Read More

    Dermatological Complications After Solid Organ Transplantation.
    Clin Rev Allergy Immunol 2018 Feb;54(1):185-212
    Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
    Organ transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e. Read More

    Sebaceous lesions of the skin.
    Pathology 2017 Dec 25;49(7):688-697. Epub 2017 Oct 25.
    Dermatopathology Group, Department of Anatomical Pathology, PathWest, Perth, Australia; School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia. Electronic address:
    Sebaceous differentiation is commonly seen in cutaneous neoplasms, both in the context of lesions showing predominantly sebaceous differentiation (e.g., sebaceous adenoma, sebaceoma and sebaceous carcinoma), or as more focal sebaceous components in neoplasms with other primary lines of differentiation. Read More

    Evaluation and comparison of staining patterns of factor XIIIa (AC-1A1), adipophilin and GATA3 in sebaceous neoplasia.
    J Cutan Pathol 2018 Jan 19;45(1):1-7. Epub 2017 Sep 19.
    Department of Pathology, University of South Dakota, Sanford School of Medicine, Sioux Falls, South Dakota.
    Background: Reliable nuclear immunohistochemical stains for sebaceous neoplasms have not been readily available. Positive nuclear staining has been reported for GATA3 and factor XIIIa (AC-1A1). We sought to determine the diagnostic utility of these nuclear stains by comparing their staining pattern to adipophilin, a consistently positive cytoplasmic stain. Read More

    Swiss S1 guideline for the treatment of rosacea.
    J Eur Acad Dermatol Venereol 2017 Nov 21;31(11):1775-1791. Epub 2017 Aug 21.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Rosacea (in German sometimes called 'Kupferfinne', in French 'Couperose' and in Italian 'Copparosa') is a chronic and frequently relapsing inflammatory skin disease primarily affecting the central areas of the face. Its geographic prevalence varies from 1% to 22%. The differential diagnosis is wide, and the treatment is sometimes difficult and varies by stage of rosacea. Read More

    Electrosurgery for the Treatment of Moderate or Severe Rhinophyma.
    Actas Dermosifiliogr 2017 Aug 9. Epub 2017 Aug 9.
    Universidad El Bosque, Bogotá, Colombia; Servicio de Dermatología, Hospital Simón Bolívar, Bogotá, Colombia.
    Rhinophyma, a rare and progressive disfiguring condition, is thought to be the final stage of rosacea. Several surgical treatments are available, including dermabrasion, cryosurgery, scalpel excision, electrosurgery, and carbon dioxide laser. The last 2 techniques are the most effective for the management of rhinophyma. Read More

    Otophyma, Rhinophyma and Telangiectatic Rosacea - A Rare Combination in a Female Patient.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):531-532. Epub 2017 Jul 19.
    Polyclinic for Dermatology and Venerology, University Hospital Lozenetz, Academic Educational Hospital of the Saint Kliment Ohridski University, Medical Faculty, Koziak Street 1, Dermatology, Venereology and Dermatologic Surgery; Onkoderma, Private Clinic for Dermatologic Surgery, Dermatology and Surgery, Sofia 1407, Bulgaria.
    Background: Rosacea is an inflammatory facial dermatosis seen more frequently in adults in their second half of life. The phymas are a particular subtype with sebaceous gland hyperplasia and progressive fibrosis.

    Case Report: We report on the rare simultaneous occurrence of telangiectatic rosacea, otophyma and rhinophyma in a 50-year-old female with psoriatic arthritis, chronic lymphedema of the legs, and metabolic syndrome. Read More

    Genomic characterisation of Felis catus papillomavirus type 5 with proposed classification within a new papillomavirus genus.
    Vet Microbiol 2017 Aug 2;207:50-55. Epub 2017 Jun 2.
    Biochemistry Department, Otago University, 710 Cumberland Street, Dunedin, New Zealand.
    Four Felis catus papillomavirus (FcaPV) types have been fully sequenced from domestic cats. Of these, FcaPV-2 and -3 are thought to cause feline viral plaques and Bowenoid in situ carcinomas. Two short sequences of DNA from a previously unreported PV type were amplified from a feline viral plaque using consensus PCR primers. Read More

    TdT expression in normal and neoplastic sebaceous cells.
    Histopathology 2017 Dec 19;71(6):985-988. Epub 2017 Sep 19.
    Pathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Aims: Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase expressed in immature, normal and neoplastic, lymphoid or haematopoietic cells and in neuroendocrine carcinomas, such as Merkel cell carcinoma and small-cell carcinoma. It has not yet been described in cells of epithelial origin. After observing TdT immunoreactivity in normal sebaceous glands, we analysed its spectrum of expression in cases of sebaceous cell hyperplasia (SGH) and sebaceous cell neoplasm. Read More

    Managing Rhinophyma by Trimodal Therapy-Novel Approach.
    Indian J Otolaryngol Head Neck Surg 2017 Jun 5;69(2):176-180. Epub 2017 Jan 5.
    Department of Dermatology and Venereal Diseases, Rajarajeswari Medical College and Hospital, Bangalore, India.
    Rhinophyma is characterized by nodular thickening of the Nasal skin, sebaceous gland hyperplasia, dilated pores, and in its late stage, fibrosis. In severe cases, it results in loss of normal facial contours, significant disfigurement, and social isolation. Treatment options for severe rhinophyma include cryosurgery, partial-thickness decortications with subsequent secondary reepithelialisation, laser ablation, full thickness resection with graft or flap reconstruction, excision by electrocautery or radio frequency. Read More

    Ichthyosis fetalis in a cross-bred lamb.
    Vet Dermatol 2017 Oct 5;28(5):516-e125. Epub 2017 Jun 5.
    Department of Veterinary Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 30123-970, Brazil.
    Background: Ichthyosis is a dermatological disease characterized by varying degrees of generalized hyperkeratosis and alopecia. Two congenital forms of ichthyosis are recognized in animals: fetalis (IF) and congenita. The disease occurs rarely in cattle, swine, dogs, chickens and a goat; it has not been reported in sheep. Read More

    Eruptive sebaceous hyperplasia as a side effect of oral tacrolimus in a renal transplant recipient.
    Dermatol Online J 2017 May 15;23(5). Epub 2017 May 15.
    Department of Dermatology, Johns Hopkins Hospital, and Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Sebaceous hyperplasia, a benign proliferation ofsebaceous glands, has been well documented in organ transplant recipients treated with cyclosporine. Sebaceous hyperplasia has not been strongly associated with any other immunosuppressive medications. We report a case of eruptive sebaceous hyperplasia in a renal transplant recipient with no previous exposure to cyclosporine that was recently started on tacrolimus, mycophenolate mofetil, and prednisone. Read More

    An immunohistochemical analysis of lymphocytic infiltrations in canine skin cancers.
    Pol J Vet Sci 2017 Mar;20(1):141-147
    Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Read More

    Sebaceous Neoplasms.
    Surg Pathol Clin 2017 Jun;10(2):367-382
    Department of Dermatology, University of Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany; Labor für Dermatohistologie und Oralpathologie, Bayerstrasse 69, 80335 München, Munich, Germany. Electronic address:
    Sebaceous skin tumors are classified into sebaceous adenoma, sebaceoma, and sebaceous carcinoma. An additional group of cystic sebaceous tumors indicate the Muir-Torre syndrome (MTS). Cystic sebaceous tumors are considered as morphologic variants of the 3 main categories. Read More

    Laser-Assisted Photodynamic Therapy: Two Novel Protocols for Enhanced Treatment Results.
    J Drugs Dermatol 2017 Apr;16(4):329-331

    Photodynamic therapy (PDT) uses a topical photosensitizing agent which is activated by a light source to cause destruction of specific cells. Commonly used for the treatment of actinic keratoses and photodamage, PDT can also be used for other conditions including acne and sebaceous hyperplasia. Here we report our experience with two treatment protocols. Read More

    Multiple viral plaques with sebaceous differentiation associated with an unclassified papillomavirus type in a cat.
    N Z Vet J 2017 Jul 20;65(4):219-223. Epub 2017 Apr 20.
    d New Zealand Veterinary Pathology Ltd , Palmerston North , New Zealand.
    CASE HISTORY AND CLINICAL FINDINGS A 15-year-old neutered male domestic short-haired cat was presented due to multiple 0.5-2 cm-diameter crusting plaques in the left preauricular region, over the bridge of nose, and in the right periocular region. The plaques did not appear to cause discomfort. Read More

    Bilateral lacrimal caruncle lesions.
    Nagoya J Med Sci 2017 Feb;79(1):85-90
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    A 65-year-old man was referred to our hospital for the treatment of a lesion on the medial lacrimal canthus of both eyes. He had a history of perinuclear anti-neutrophil cytoplasmic antibodies, i.e. Read More

    Evaluation of the Efficacy of Cryosurgery in Patients With Sebaceous Hyperplasia of the Face.
    J Cutan Med Surg 2017 May/Jun;21(3):202-206. Epub 2016 Dec 27.
    1 Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Dermatology, Ankara, Turkey.
    Background: Cryosurgery is an effective treatment for sebaceous hyperplasia, but there have been few clinical studies.

    Objectives: The aim of this study was to evaluate the efficacy and safety of cryosurgery in the treatment of sebaceous hyperplasia.

    Methods: Cryosurgery was performed 6 times, at 2-week intervals, with liquid nitrogen, and evaluated in 40 patients with 517 lesions ranging from 2 to 9 mm over the forehead, cheeks, and chin. Read More

    Photodynamic Therapy and Skin Appendage Disorders: A Review.
    Skin Appendage Disord 2017 Jan 8;2(3-4):166-176. Epub 2016 Dec 8.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. Read More

    Epidermal psoriasiform hyperplasia, an unrecognized sign of folliculitis decalvans: A histological study of 26 patients.
    J Cutan Pathol 2017 Apr 27;44(4):352-357. Epub 2017 Jan 27.
    Hôpital Saint-Louis, Centre Sabouraud, Paris, France.
    Background: Follicular hyperkeratosis along with hyperplasia of the follicular and interfollicular epithelia are major histopathological characteristics of hidradenitis suppurativa (HS). The presence of an occasional thickening of lesional skin in some folliculitis decalvans (FD) patients and histological similarities between FD and HS led us to look for epidermal hyperplasia and follicular hyperkeratosis in FD patients.

    Patients And Method: We performed a retrospective histological analysis of 26 patients with FD. Read More

    Carcinoid-Like/Labyrinthine Pattern in Sebaceous Neoplasms Represents a Sebaceous Mantle Phenotype: Immunohistochemical Analysis of Aberrant Vimentin Expression and Cytokeratin 20-Positive Merkel Cell Distribution.
    Am J Dermatopathol 2017 Nov;39(11):803-810
    *Department of Diagnostic Pathology, Kainan Hospital, Aichi, Japan; †Department of Pathology and Cytology, Karolinska University Hospital, Huddinge, Sweden; ‡Sapporo Dermatopathology Institute, Sapporo, Japan; §Fukumoto Dermatopathology Clinic, Nara, Japan; and ¶Division of Dermatology, Nakao Clinic, Saga, Japan.
    This study investigated the nature of carcinoid-like, labyrinthine, rippled, and conventional cell arrangements in sebaceous neoplasms, focusing on vimentin expression and Merkel cell distribution in sebaceous neoplasms relative to these findings in normal sebaceous units and other sebaceous conditions. Immunohistochemistry for vimentin and cytokeratin 20 (CK20) was evaluated in carcinoid-like (n = 2), labyrinthine (n = 4), rippled (n = 3), and conventional (n = 6) sebaceomas; sebaceous mantle hyperplasia (n = 1); steatocystomas (n = 5); fibrofolliculomas (n = 4); sebaceous mantleoma (n = 1); sebaceous gland hyperplasias (n = 4); sebaceous adenomas (n = 4); and sebaceous carcinomas (n = 4) as well as normal skin tissue. The sebaceous mantle and its hamartoma (fibrofolliculoma) showed weak positivity for vimentin in the basal layer of the epithelial component and contained a few CK20-positive Merkel cells within the epithelial component, whereas mature sebaceous lobules were negative for vimentin and did not contain any Merkel cells. Read More

    Clinical features of Korean patients with rhinophyma.
    J Dermatol 2017 Jun 27;44(6):710-712. Epub 2016 Dec 27.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Rhinophyma results from hyperplasia of the sebaceous glands and connective tissue. Clinical features in Asian rhinophyma patients are largely underreported. In this study, we aimed to evaluate the clinical features of rhinophyma in Korean patients. Read More

    Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation.
    Dermatopathology (Basel) 2016 Oct-Dec;3(4):79-82. Epub 2016 Nov 12.
    Division of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland.
    Many cutaneous complications have been described in patients treated with cyclosporin. Alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent. However, the occurrence of sebaceous hyperplasia is exceptional. Read More

    Prevalence and characterization of neonatal skin disorders in the first 72h of life.
    J Pediatr (Rio J) 2017 May - Jun;93(3):238-245. Epub 2016 Nov 19.
    Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-graduação em Saúde da Criança e Adolescente, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre (HCPA), Departamento de Dermatologia, Porto Alegre, RS, Brazil.
    Objective: To determine the prevalence of neonatal dermatological findings and analyze whether there is an association between these findings and neonatal and pregnancy characteristics and seasonality.

    Methods: Newborns from three maternity hospitals in a Brazilian capital city were randomly selected to undergo dermatological assessment by dermatologists.

    Results: 2938 neonates aged up to three days of life were randomly selected, of whom 309 were excluded due to Intensive Care Unit admission. Read More

    Histopathologic pitfalls of Mohs micrographic surgery and a review of tumor histology.
    Wien Med Wochenschr 2016 Nov 10. Epub 2016 Nov 10.
    Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Università Degli Studi "G. Marconi", Rome, Italy.
    Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Read More

    Cutaneous Horn of the Eyelid in 13 Cases.
    Ophthal Plast Reconstr Surg 2017 Jul/Aug;33(4):233-236
    *Ocular Oncology Service and †Department of Ophthalmic Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
    Introduction: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid.

    Objective: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. Read More

    Tarsal Glandular Hyperplasia in Pachydermoperiostosis and Implications for Ptosis Correction.
    Ophthal Plast Reconstr Surg 2017 Jul/Aug;33(4):e92-e94
    *Division of Oculoplastic and Orbit, Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery; and †Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
    Pachydermoperiostosis is a rare genetic disease that causes major bone and skin changes. Severe ptosis is a prominent finding in this peculiar condition. We report here 2 patients with typical features of pachydermoperiostosis. Read More

    Speckle-variance optical coherence tomography: a novel approach to skin cancer characterization using vascular patterns.
    Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.
    SUNY Downstate Medical Center; New York Harbor Healthcare System; Mount Sinai Medical Center.
    Non-invasive imaging devices are currently being utilized in research and clinical settings to help visualize, characterize, anddiagnose cancers of the skin. Speckle-variance optical coherence tomography (svOCT) is one such technology that offers considerable promise for non-invasive, real time detection of skin cancers given its added ability to show changes in microvasculature. We present four early lesions of the face namely sebaceous hyperplasia, basal cell skin cancer, pigmented actinic keratosis, and malignant melanoma in situ that each display different important identification markers on svOCT. Read More

    Linear ectopic sebaceous hyperplasia of the penis: the last memory of Tyson's glands.
    G Ital Dermatol Venereol 2016 Sep 6. Epub 2016 Sep 6.
    Clinica Dermatologica, La Sapienza University of Rome, Rome, Italy -
    Pathologists who find ectopic glands on the glans and/or on the prepuce, often describe them as Tyson's glands. In this regard, the term Tyson's glands can be replaced by two different descriptive expressions: papillomatosis corona penis and ectopic sebaceous glands. A 15-year old Caucasian male patient presented to our Institute with multiple and asymptomatic circular skin colored-to-yellowish papules at the level of the foreskin, also affecting the shaft of the penis, where they assumed a linear feature. Read More

    Caruncular and Pericaruncular Sebaceous Gland Hyperplasia: A Report of 2 Cases and Literature Review.
    Eye Contact Lens 2016 Jul 12. Epub 2016 Jul 12.
    Department of Ophthalmology (M.O., M.S., M.D., J.S.), Tokyo Dental College Ichikawa General Hospital, Chiba, Japan; Department of Ophthalmology (M.O., M.D., K.T.), Keio University School of Medicine, Tokyo, Japan; Department of Ophthalmology (M.S.), Fukushima University School of Medicine, Fukushima, Japan; Department of Pathology and Laboratory Medicine (J.M., Y.T.), Tokyo Dental College Ichikawa General Hospital, Chiba, Japan; and Department of Ophthalmology (H.O.), Jichi Medical University, Saitama, Japan.
    Purpose: To report the clinical and histopathological features of two patients with caruncular and pericaruncular sebaceous gland hyperplasia (SGH) with a literature review.

    Methods: We performed a retrospective pathology database search of 1195 ophthalmic specimens receiving the clinical diagnosis of SGH for caruncular/pericaruncular lesions during 2004 to 2014 at Tokyo Dental College, Ichikawa General Hospital. Paraffin sections were stained with hematoxylin and eosin. Read More

    Lrig1 Expression in Human Sebaceous Gland Tumors.
    Dermatopathology (Basel) 2016 Apr-Jun;3(2):44-54. Epub 2016 Jun 1.
    Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.
    Background: Sebaceous glands contribute significantly to the barrier functions of the skin. However, little is known about their homeostasis and tumorigenesis. Recently, increased expression of stem cell marker Lrig1 has been reported in sebaceous carcinoma-like tumors of K14ΔNLef1 transgenic mice. Read More

    Tissue injury and repair following cutaneous exposure of mice to sulfur mustard.
    Ann N Y Acad Sci 2016 08 2;1378(1):118-123. Epub 2016 Jul 2.
    Department of Environmental Science, New York Medical College, Valhalla, New York.
    In mouse skin, sulfur mustard (SM) is a potent vesicant, damaging both the epidermis and the dermis. The extent of wounding is dependent on the dose of SM and the duration of exposure. Initial responses include erythema, pruritus, edema, and xerosis; this is followed by an accumulation of inflammatory leukocytes in the tissue, activation of mast cells, and the release of mediators, including proinflammatory cytokines and bioactive lipids. Read More

    Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?
    J Invest Dermatol 2016 Sep 14;136(9):1792-800. Epub 2016 Jun 14.
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:
    In a transcriptome study of lesional psoriatic skin (PP) versus normal skin, we found a coexpressed gene module (N5) enriched 11.5-fold for lipid biosynthetic genes. We also observed fewer visible hairs in PP skin, compared with uninvolved nonlesional psoriatic skin or normal skin (P < 0. Read More

    sPLA2 -IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation.
    Stem Cells 2016 09 8;34(9):2407-17. Epub 2016 Jul 8.
    Stem Cell Biology Group, Waghmare Lab.
    Secretory phospholipase A2 Group-IIA (sPLA2 -IIA) catalyzes the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. sPLA2 -IIA is deregulated in various cancers; however, its role in hair follicle stem cell (HFSC) regulation is obscure. Here we report a transgenic mice overexpressing sPLA2 -IIA (K14-sPLA2 -IIA) showed depletion of HFSC pool. Read More

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