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    1 OF 13

    Photodynamic Therapy and Skin Appendage Disorders: A Review.
    Skin Appendage Disord 2017 Jan 8;2(3-4):166-176. Epub 2016 Dec 8.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. Read More

    Epidermal psoriasiform hyperplasia, an unrecognized sign of folliculitis decalvans: A histological study of 26 patients.
    J Cutan Pathol 2017 Jan 9. Epub 2017 Jan 9.
    Hôpital Saint-Louis, Centre Sabouraud, Paris, France.
    Background: Follicular hyperkeratosis along with hyperplasia of the follicular and interfollicular epithelia are major histopathological characteristics of hidradenitis suppurativa (HS). The presence of an occasional thickening of lesional skin in some folliculitis decalvans (FD) patients and histological similarities between FD and HS led us to look for epidermal hyperplasia and follicular hyperkeratosis in FD patients.

    Patients And Method: We performed a retrospective histological analysis of 26 patients with FD. Read More

    Carcinoid-Like/Labyrinthine Pattern in Sebaceous Neoplasms Represents a Sebaceous Mantle Phenotype: Immunohistochemical Analysis of Aberrant Vimentin Expression and Cytokeratin 20-Positive Merkel Cell Distribution.
    Am J Dermatopathol 2016 Dec 23. Epub 2016 Dec 23.
    *Department of Diagnostic Pathology, Kainan Hospital, Aichi, Japan;†Department of Pathology and Cytology, Karolinska University Hospital, Huddinge, Sweden;‡Sapporo Dermatopathology Institute, Sapporo, Japan;§Fukumoto Dermatopathology Clinic, Nara, Japan; and¶Division of Dermatology, Nakao Clinic, Saga, Japan.
    This study investigated the nature of carcinoid-like, labyrinthine, rippled, and conventional cell arrangements in sebaceous neoplasms, focusing on vimentin expression and Merkel cell distribution in sebaceous neoplasms relative to these findings in normal sebaceous units and other sebaceous conditions. Immunohistochemistry for vimentin and cytokeratin 20 (CK20) was evaluated in carcinoid-like (n = 2), labyrinthine (n = 4), rippled (n = 3), and conventional (n = 6) sebaceomas; sebaceous mantle hyperplasia (n = 1); steatocystomas (n = 5); fibrofolliculomas (n = 4); sebaceous mantleoma (n = 1); sebaceous gland hyperplasias (n = 4); sebaceous adenomas (n = 4); and sebaceous carcinomas (n = 4) as well as normal skin tissue. The sebaceous mantle and its hamartoma (fibrofolliculoma) showed weak positivity for vimentin in the basal layer of the epithelial component and contained a few CK20-positive Merkel cells within the epithelial component, whereas mature sebaceous lobules were negative for vimentin and did not contain any Merkel cells. Read More

    Clinical features of Korean patients with rhinophyma.
    J Dermatol 2016 Dec 27. Epub 2016 Dec 27.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Rhinophyma results from hyperplasia of the sebaceous glands and connective tissue. Clinical features in Asian rhinophyma patients are largely underreported. In this study, we aimed to evaluate the clinical features of rhinophyma in Korean patients. Read More

    Multiple Eruptive Sebaceous Hyperplasia Secondary to Cyclosporin in a Patient with Bone Marrow Transplantation.
    Dermatopathology (Basel) 2016 Oct-Dec;3(4):79-82. Epub 2016 Nov 12.
    Division of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland.
    Many cutaneous complications have been described in patients treated with cyclosporin. Alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent. However, the occurrence of sebaceous hyperplasia is exceptional. Read More

    Prevalence and characterization of neonatal skin disorders in the first 72h of life.
    J Pediatr (Rio J) 2016 Nov 19. Epub 2016 Nov 19.
    Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-graduação em Saúde da Criança e Adolescente, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre (HCPA), Departamento de Dermatologia, Porto Alegre, RS, Brazil.
    Objective: To determine the prevalence of neonatal dermatological findings and analyze whether there is an association between these findings and neonatal and pregnancy characteristics and seasonality.

    Methods: Newborns from three maternity hospitals in a Brazilian capital city were randomly selected to undergo dermatological assessment by dermatologists.

    Results: 2938 neonates aged up to three days of life were randomly selected, of whom 309 were excluded due to Intensive Care Unit admission. Read More

    Histopathologic pitfalls of Mohs micrographic surgery and a review of tumor histology.
    Wien Med Wochenschr 2016 Nov 10. Epub 2016 Nov 10.
    Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Università Degli Studi "G. Marconi", Rome, Italy.
    Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Read More

    Cutaneous Horn of the Eyelid in 13 Cases.
    Ophthal Plast Reconstr Surg 2016 Nov 2. Epub 2016 Nov 2.
    *Ocular Oncology Service and †Department of Ophthalmic Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
    Introduction: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid.

    Objective: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. Read More

    Tarsal Glandular Hyperplasia in Pachydermoperiostosis and Implications for Ptosis Correction.
    Ophthal Plast Reconstr Surg 2016 Oct 11. Epub 2016 Oct 11.
    *Division of Oculoplastic and Orbit, Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery; and †Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
    Pachydermoperiostosis is a rare genetic disease that causes major bone and skin changes. Severe ptosis is a prominent finding in this peculiar condition. We report here 2 patients with typical features of pachydermoperiostosis. Read More

    Speckle-variance optical coherence tomography: a novel approach to skin cancer characterization using vascular patterns.
    Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.
    SUNY Downstate Medical Center; New York Harbor Healthcare System; Mount Sinai Medical Center.
    Non-invasive imaging devices are currently being utilized in research and clinical settings to help visualize, characterize, anddiagnose cancers of the skin. Speckle-variance optical coherence tomography (svOCT) is one such technology that offers considerable promise for non-invasive, real time detection of skin cancers given its added ability to show changes in microvasculature. We present four early lesions of the face namely sebaceous hyperplasia, basal cell skin cancer, pigmented actinic keratosis, and malignant melanoma in situ that each display different important identification markers on svOCT. Read More

    Linear ectopic sebaceous hyperplasia of the penis: the last memory of Tyson's glands.
    G Ital Dermatol Venereol 2016 Sep 6. Epub 2016 Sep 6.
    Clinica Dermatologica, La Sapienza University of Rome, Rome, Italy -
    Pathologists who find ectopic glands on the glans and/or on the prepuce, often describe them as Tyson's glands. In this regard, the term Tyson's glands can be replaced by two different descriptive expressions: papillomatosis corona penis and ectopic sebaceous glands. A 15-year old Caucasian male patient presented to our Institute with multiple and asymptomatic circular skin colored-to-yellowish papules at the level of the foreskin, also affecting the shaft of the penis, where they assumed a linear feature. Read More

    Caruncular and Pericaruncular Sebaceous Gland Hyperplasia: A Report of 2 Cases and Literature Review.
    Eye Contact Lens 2016 Jul 12. Epub 2016 Jul 12.
    Department of Ophthalmology (M.O., M.S., M.D., J.S.), Tokyo Dental College Ichikawa General Hospital, Chiba, Japan; Department of Ophthalmology (M.O., M.D., K.T.), Keio University School of Medicine, Tokyo, Japan; Department of Ophthalmology (M.S.), Fukushima University School of Medicine, Fukushima, Japan; Department of Pathology and Laboratory Medicine (J.M., Y.T.), Tokyo Dental College Ichikawa General Hospital, Chiba, Japan; and Department of Ophthalmology (H.O.), Jichi Medical University, Saitama, Japan.
    Purpose: To report the clinical and histopathological features of two patients with caruncular and pericaruncular sebaceous gland hyperplasia (SGH) with a literature review.

    Methods: We performed a retrospective pathology database search of 1195 ophthalmic specimens receiving the clinical diagnosis of SGH for caruncular/pericaruncular lesions during 2004 to 2014 at Tokyo Dental College, Ichikawa General Hospital. Paraffin sections were stained with hematoxylin and eosin. Read More

    Lrig1 Expression in Human Sebaceous Gland Tumors.
    Dermatopathology (Basel) 2016 Apr-Jun;3(2):44-54. Epub 2016 Jun 1.
    Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.
    Background: Sebaceous glands contribute significantly to the barrier functions of the skin. However, little is known about their homeostasis and tumorigenesis. Recently, increased expression of stem cell marker Lrig1 has been reported in sebaceous carcinoma-like tumors of K14ΔNLef1 transgenic mice. Read More

    Tissue injury and repair following cutaneous exposure of mice to sulfur mustard.
    Ann N Y Acad Sci 2016 Aug 2;1378(1):118-123. Epub 2016 Jul 2.
    Department of Environmental Science, New York Medical College, Valhalla, New York.
    In mouse skin, sulfur mustard (SM) is a potent vesicant, damaging both the epidermis and the dermis. The extent of wounding is dependent on the dose of SM and the duration of exposure. Initial responses include erythema, pruritus, edema, and xerosis; this is followed by an accumulation of inflammatory leukocytes in the tissue, activation of mast cells, and the release of mediators, including proinflammatory cytokines and bioactive lipids. Read More

    Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?
    J Invest Dermatol 2016 Sep 14;136(9):1792-800. Epub 2016 Jun 14.
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address:
    In a transcriptome study of lesional psoriatic skin (PP) versus normal skin, we found a coexpressed gene module (N5) enriched 11.5-fold for lipid biosynthetic genes. We also observed fewer visible hairs in PP skin, compared with uninvolved nonlesional psoriatic skin or normal skin (P < 0. Read More

    Skin diseases of the nose.
    Am J Rhinol Allergy 2016 May;30(3):83-90
    Otorhinolaryngology and Head and Neck Surgery Clinic, Bakirkoy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
    Objectives: The goal of this study was to review the main lesion types of the nasal skin and appropriate treatment strategies rather than to present a comprehensive list of all diseases that affect the skin that can involve the nose.

    Methods: We reviewed the main nasal skin lesion types and available treatment strategies. Nasal skin lesions were classified as benign, premalignant, or malignant. Read More

    Otophyma: a rare variant of phymatous rosacea.
    Am J Otolaryngol 2016 May-Jun;37(3):251-4. Epub 2016 Jan 22.
    Reina Sofía University Hospital, Córdoba, Spain.
    Background: Phymatous rosacea is characterized by thickened skin and irregular surface contours as the result of variable combinations of fibrosis, sebaceous hyperplasia and lymphoedema. Otic phyma is rarely seen and has been rarely reported in the English literature.

    Methods: We present another case of this uncommon condition, frequently misdiagnosed, maybe due to its underrecognition. Read More

    Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a highly sensitive marker of sebaceous differentiation in normal and neoplastic sebocytes.
    J Cutan Pathol 2016 Aug 14;43(8):657-62. Epub 2016 Jun 14.
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Background: Sebaceous proliferations are common and may be confused with other cutaneous neoplasms. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. We incidentally observed strong factor XIIIa (Ventana clone AC-1A1 on Ventana Benchmark Ultra stainer) nuclear staining in normal sebaceous glands and hypothesized that this might be a useful marker in sebaceous proliferations. Read More

    Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms.
    J Cutan Pathol 2016 Aug 10;43(8):649-56. Epub 2016 Jun 10.
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Sebaceous carcinoma is a rare but serious malignancy that may be difficult to diagnose when poorly differentiated. Other epithelial tumors with clear cell change may mimic sebaceous carcinoma. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. Read More

    Presenile diffuse familial sebaceous hyperplasia successfully treated with low-dose isotretinoin: A report of two cases and review of the published work.
    J Dermatol 2016 Oct;43(10):1205-1208
    Department of Dermatology, Cathay General Hospital, Taipei City, Taiwan.
    Presenile diffuse familial sebaceous hyperplasia (PDFSH) presents as extensive yellowish papules with central umbilication on the face without involvement of periorificial regions and occurs in adolescents or young adults with a positive family history. Thirteen cases of PDFSH have been reported in the English-language published work, 10 of which responded to oral isotretinoin from 0.5 to 1 mg/kg per day but recurrences were often observed. Read More

    Cyclosporine-induced sebaceous hyperplasia in a hematopoetic stem cell transplant patient: delayed onset of a common adverse event.
    Dermatol Online J 2016 Jan 15;22(1). Epub 2016 Jan 15.
    University of California Davis Medical Center, Sacramento.
    Cyclosporine-induced sebaceous hyperplasia (SH) is a well-documented entity, occurring in up to 30% of renal transplant patients treated with cyclosporine and has also been reported to occur following heart or hematopoetic stem cell transplantation (HCST). Cyclosporine has a stimulatory effect on undifferentiated sebocytes, resulting in the clinical and histologic findings in these patients. Sebaceous hyperplasia most commonly presents as asymptomatic papules over the face, chest, or groin. Read More

    Hair Follicle Nevus with Sebaceous Hyperplasia: A Dermoscopic Observation.
    Case Rep Dermatol 2015 Sep-Dec;7(3):358-62. Epub 2015 Dec 23.
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
    We herein report a case of hair follicle nevus, a rare hamartoma found on the face and showing follicular differentiation, which was associated with sebaceous hyperplasia. Dermoscopy of the lesion showed yellow globules surrounded by crown vessels/telangiectasias and scattered tiny hairs. Histopathological investigation revealed hyperplasia of the sebaceous glands and proliferation of well-differentiated vellus hair follicles. Read More

    Sebaceous Hyperplasia Mimicking Linear Wart over Ear.
    Int J Trichology 2015 Oct-Dec;7(4):170-2
    Department of Dermatology and Venereology, Pramukshwami Medical College, Karamsad, Gujarat, India.
    Sebaceous hyperplasia (SH), a common, benign condition of sebaceous gland, presents most commonly over face. Lesions are usually described as asymptomatic, soft, discrete, and yellow with a surface that ranges from smooth to slightly verrucous. The pathogenesis is not fully understood. Read More

    Using typical endoscopic features to diagnose esophageal squamous papilloma.
    World J Gastroenterol 2016 Feb;22(7):2349-56
    Ming-Wun Wong, Ming-Joug Bair, Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taitung 950, Taiwan.
    Aim: To better understand some of the superficial tiny lesions that are recognized as squamous papilloma of the esophagus (SPE) and receive a different pathological diagnosis.

    Methods: All consecutive patients with esophageal polypoid lesions detected by routine endoscopy at our Endoscopy Centre between October 2009 and June 2014 were retrospectively analysed. We enrolled patients with SPE or other superficial lesions to investigate four key endoscopic appearances (whitish color, exophytic growth, wart-like shape, and surface vessels) and used narrow band imaging (NBI) to distinguish their differences. Read More

    Facial Scars following Toxic Epidermal Necrolysis: Role of Adnexal Involvement?
    Dermatology 2016 12;232(2):220-3. Epub 2016 Feb 12.
    Referral Center for Autoimmune and Toxic Bullous Diseases, Dermatology Department, Hx00F4;pitaux Universitaires Henri-Mondor, Universitx00E9; Paris-Est Crx00E9;teil, Crx00E9;teil, France.
    Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse drug reaction leading to extensive sloughing of the skin. Late cutaneous complications such as pigmentation disorders are frequently reported. In this report, we present particular facial cutaneous sequelae with histological analysis after TEN. Read More

    KRAS, HRAS and EGFR Mutations in Sporadic Sebaceous Gland Hyperplasia.
    Acta Derm Venereol 2016 Aug;96(6):737-41
    Department of Dermatology, University of Regensburg, DE-93053 Regensburg, Germany.
    Sporadic sebaceous gland hyperplasia (SGH) is a benign skin lesion, with a high prevalence in the general population. Although SGH has been attributed to both extrinsic and intrinsic factors, the underlying genetic changes have not yet been characterized. Recently, HRAS and KRAS mutations have been identified in sebaceous naevus, a hamartoma sharing histological characteristics with SGH. Read More

    Premature sebaceous hyperplasia with satisfactory response to oral isotretinoin.
    Indian J Dermatol Venereol Leprol 2016 Jan-Feb;82(1):113
    Department of Dermatology, Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan; Department of Dermatology, Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China.

    Phenotype/genotype correlations in epidermal nevus syndrome as a neurocristopathy.
    Handb Clin Neurol 2015 ;132:9-25
    Departments of Paediatrics, Pathology (Neuropathology) and Clinical Neurosciences, Calgary, Alberta, Canada.
    Epidermal nevus syndrome (ENS) is a term that encompasses several phenotypes defined by the association of an epidermal nevus with one or more congenital systemic anomalies, mainly ocular, osseous and cerebral. The two most frequent, keratinocytic nevus syndrome and linear sebaceous nevus syndrome, also correspond to the neurological phenotypes. They both exhibit overlapping and distinctive features but same etiology: post-zygotic mosaic mutations in RAS genes. Read More

    Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands.
    Exp Dermatol 2016 Mar 12;25(3):187-93. Epub 2016 Jan 12.
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
    To explore the role of amphiregulin in inflammatory epidermal hyperplasia, we overexpressed human AREG (hAREG) in FVB/N mice using a bovine K5 promoter. A construct containing AREG coding sequences flanked by 5' and 3' untranslated region sequences (AREG-UTR) led to a >10-fold increase in hAREG expression compared to an otherwise-identical construct containing only the coding region (AREG-CDR). AREG-UTR mice developed tousled, greasy fur as well as elongated nails and thickened, erythematous tail skin. Read More

    Diagnosing Common Benign Skin Tumors.
    Am Fam Physician 2015 Oct;92(7):601-7
    Naval Hospital Jacksonville, Jacksonville, FL, USA.
    Patients will experience a wide range of skin growths and changes over their lifetime. Family physicians should be able to distinguish potentially malignant from benign skin tumors. Most lesions can be diagnosed on the basis of history and clinical examination. Read More

    [High-resolution ultrasonography for differential diagnosis between nodular basal carcinoma and sebaceous hyperplasia of the face: A pilot study].
    Ann Dermatol Venereol 2015 Nov 14;142(11):646-52. Epub 2015 Sep 14.
    Service de dermatologie, CHR d'Orléans, 1, rue Porte-Madeleine, 45032 Orléans, France.
    Background: Clinical differential diagnosis between incipient nodular basal carcinoma (NBC) and sebaceous hyperplasia (SH) of the face is difficult in some cases. A comparative histological analysis of these two entities led us to the hypothesis that 20MHz high-resolution ultrasonography (HRUS) may enable differentiation between NBC and SH.

    Patients And Methods: Seventy-seven facial tumours requiring histological confirmation to distinguish between NBC and SH were scanned using HRUS before excision. Read More

    Nevus sebaceus: a clinicopathological study of 168 cases and review of the literature.
    Int J Dermatol 2016 Feb 17;55(2):193-200. Epub 2015 Sep 17.
    Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Nevus sebaceus is a hamartoma composed of abnormal epidermal and dermal components with clinical and histopathological features that change with aging. Prophylactic excision of the lesion was advised historically considering its potential for giving rise to malignant tumors. However, whether early prophylactic excision should be performed has been questioned recently as most of the tumors have been found to be benign in origin. Read More

    Expression of Malic Enzymes in Sebaceous Lesions.
    Am J Dermatopathol 2016 Aug;38(8):580-5
    Department of Pathology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
    Malic enzymes (MEs) are involved in fatty acid biosynthesis and lipid accumulation, and their expression in sebocytes and sebaceous lesions has not been investigated. The aims of this study were to examine ME1 and ME2 expression in normal skin and sebaceous lesions. A total of 68 cases including 5 specimens of normal skin, 12 facial lesions showing sebaceous hyperplasia, 18 sebaceous adenomas, 10 sebaceomas, 13 steatocystomas, and 10 sebaceous carcinomas were examined for the expression of ME1 and ME2. Read More

    Lymphocytic Arteritis in Epstein-Barr Virus Vulvar Ulceration (Lipschütz Disease): A Report of 7 Cases.
    Am J Dermatopathol 2015 Sep;37(9):691-8
    *Divisions of Dermatology and Dermatopathology, Albany Medical College, Albany, NY; †Department of Pathology, Hospital Obrero Nro 1, Caja Nacional de Salud, La Paz, Bolivia; ‡Department of Pathology, Universidade Federal do Parana, Curitiba, Brazil; and §Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany.
    Epstein-Barr virus (EBV) infection can rarely present as painful genital ulcers, mostly in young female adolescents. Typically diagnosed by clinical findings, EBV vulvar ulceration (EBVVU) is rarely biopsied. Herein, the authors report the histopathology in 8 biopsies from 7 EBVVU patients, all serologically confirmed for acute (4/7) or reactivated-chronic (3/7) EBV infection. Read More

    Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene.
    J Invest Dermatol 2015 Dec 19;135(12):3133-43. Epub 2015 Aug 19.
    Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas, USA.
    Here we describe a spontaneous mutation in the Zdhhc13 (zinc finger, DHHC domain containing 13) gene (also called Hip14l), one of 24 genes encoding palmitoyl acyltransferase (PAT) enzymes in the mouse. This mutation (Zdhhc13luc) was identified as a nonsense base substitution, which results in a premature stop codon that generates a truncated form of the ZDHHC13 protein, representing a potential loss-of-function allele. Homozygous Zdhhc13luc/Zdhhc13luc mice developed generalized hypotrichosis, associated with abnormal hair cycle, epidermal and sebaceous gland hyperplasia, hyperkeratosis, and increased epidermal thickness. Read More

    Rosacea: Diagnosis and Treatment.
    Am Fam Physician 2015 Aug;92(3):187-96
    Louisiana State University Department of Family Medicine, University Hospital and Clinics, Lafayette, LA, USA.
    Rosacea is a chronic facial skin condition of unknown cause. It is characterized by marked involvement of the central face with transient or persistent erythema, telangiectasia, inflammatory papules and pustules, or hyperplasia of the connective tissue. Transient erythema, or flushing, is often accompanied by a feeling of warmth. Read More

    Traumatic neuroma of the penis after circumcision--Case report.
    An Bras Dermatol 2015 May-Jun;90(3):397-9. Epub 2015 Jun 1.
    Complexo Hospitalar Padre Bento de Guarulhos, Guarulhos, SP, Brazil.
    Traumatic neuromas are tumors resulting from hyperplasia of axons and nerve sheath cells after section or injury to the nervous tissue. We present a case of this tumor, confirmed by anatomopathological examination, in a male patient with history of circumcision. Knowledge of this entity is very important in achieving the differential diagnosis with other lesions that affect the genital area such as condyloma acuminata, bowenoid papulosis, lichen nitidus, sebaceous gland hyperplasia, achrochordon and pearly penile papules. Read More

    Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence.
    J Invest Dermatol 2015 Nov 23;135(11):2584-92. Epub 2015 Apr 23.
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, Yokohama, Japan.
    The atypical protein kinase C (aPKC)-partition-defective (PAR) complex regulates the formation of tight junctions and apico-basal epithelial polarity. To examine the role of this complex in the epidermis, we generated mutant mice harboring epidermal-specific deletion of aPKCλ (conditional knock-out (cKO)), a major component of the aPKC-PAR complex. The mutant mice exhibited abnormal hair follicle (HF) cycling, progressive losses of pelage hairs and vibrissae, and altered differentiation into the epidermis and sebaceous gland. Read More

    Major pathophysiological correlations of rosacea: a complete clinical appraisal.
    Int J Med Sci 2015 5;12(5):387-96. Epub 2015 May 5.
    2. Department of Trauma and Emergency, University Malaya Medical Center, 59100 Kuala Lumpur, Malaysia.
    Background: Rosacea is a characteristic cutaneous disorder with a diverse clinical manifestations ranging from facial vascular hyper-reactivity to sebaceous gland hyperplasia. Many theories on pathophysiology of rosacea were proposed over the past decade, however the pathogenicity is poorly understood.

    Aim: To review the evidence on different pathophysiological correlations of rosacea. Read More

    Pathological characterization of pachydermia in pachydermoperiostosis.
    J Dermatol 2015 Jul 11;42(7):710-4. Epub 2015 May 11.
    Department of Dermatology, Toho University School of Medicine, Tokyo, Japan.
    Pachydermoperiostosis is a rare hereditary disease, which presents with the cutaneous manifestations of pachydermia and cutis verticis gyrata. Histological findings in pachydermia frequently include dermal edema, mucin deposition, elastic fiber degeneration, dermal fibrosis and adnexal hyperplasia. However, the severity of these findings varies between clinical reports, and a systematic multiple-case clinicopathological correlative analysis has not been performed to date. Read More

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