1,529 results match your criteria Sebaceous Gland Carcinoma


Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing
April 2019
1 Read

Heterogeneity of PD-L1 expression and CD8 tumor-infiltrating lymphocytes among subtypes of cutaneous adnexal carcinomas.

Cancer Immunol Immunother 2019 Apr 5. Epub 2019 Apr 5.

Pathology Department, INSERM UMR_S1165, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (APHP), 1 Avenue Claude Vellefaux, 75010, Paris, France.

Background: Adnexal carcinomas are rare and heterogeneous skin tumors, for which no standard treatments exist for locally advanced or metastatic tumors.

Aim Of The Study: To evaluate the expression of PD-L1 and CD8 in adnexal carcinomas, and to study the association between PD-L1 expression, intra-tumoral T cell CD8 infiltrate, and metastatic evolution.

Materials And Methods: Eighty-three adnexal carcinomas were included. Read More

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http://link.springer.com/10.1007/s00262-019-02334-8
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http://dx.doi.org/10.1007/s00262-019-02334-8DOI Listing
April 2019
4 Reads

Vimentin overexpression as a novel poor prognostic biomarker in eyelid sebaceous gland carcinoma.

Br J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ocular Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Vimentin is an intermediate-sized filament which is highly expressed in mesenchymal cells and is associated with epithelial-mesenchymal transition (EMT). EMT markers ZEB2 and Slug lead to Vimentin overexpression and E-cadherin loss, resulting in invasion and metastasis. However, the status of Vimentin remains unexplored in eyelid sebaceous gland carcinoma (SGC). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313285DOI Listing
April 2019
1 Read

Mohs micrographic surgery versus wide local excision for sebaceous adenocarcinoma of the eyelid : Analysis of a national database.

J Plast Reconstr Aesthet Surg 2019 Mar 2. Epub 2019 Mar 2.

Baylor College of Medicine, Houston, Texas, United States.

Background: Sebaceous adenocarcinomas are rare and potentially aggressive tumors, which typically arise in the periocular region. Surgical treatments for eyelid sebaceous adenocarcinomas include Mohs micrographic surgery (MMS) and wide local excision (WLE). The objective of this study was to compare long-term survival outcomes of MMS versus WLE techniques for eyelid sebaceous adenocarcinomas. Read More

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http://dx.doi.org/10.1016/j.bjps.2019.02.009DOI Listing
March 2019
1 Read

Clinicopathologic Characteristics and Predictors Affecting Survival Outcome of Eyelid Malignancy.

J Craniofac Surg 2019 Mar 12. Epub 2019 Mar 12.

Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

The aim of this study was to determine the clinicopathologic characteristics and evaluate the prognostic factors in eyelid malignancies. This was a retrospective, comparative, case series of 70 patients with eyelid malignancies. The mean age at diagnosis was 72. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005341DOI Listing
March 2019
1 Read

Sebaceous carcinoma in a mature teratoma of the ovary.

Autops Case Rep 2018 Oct-Dec;8(4):e2018060. Epub 2018 Oct 9.

Pathodiagnose Pathology Laboratory. Chapecó, SC, Brazil.

The finding of a sebaceous carcinoma in a mature teratoma is rare in human pathology, with fewer than 10 cases currently reported in the literature. In this article, we report a case of sebaceous carcinoma in a mature teratoma of the ovary in a 59-year-old patient and discuss its histological findings. Read More

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http://dx.doi.org/10.4322/acr.2018.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360825PMC
October 2018
5 Reads

Biophysical basis of skin cancer margin assessment using Raman spectroscopy.

Biomed Opt Express 2019 Jan 7;10(1):104-118. Epub 2018 Dec 7.

Department of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton Street C0800, Austin, TX 78712, USA.

Achieving adequate margins during tumor margin resection is critical to minimize the recurrence rate and maximize positive patient outcomes during skin cancer surgery. Although Mohs micrographic surgery is by far the most effective method to treat nonmelanoma skin cancer, it can be limited by its inherent required infrastructure, including time-consuming and expensive on-site histopathology. Previous studies have demonstrated that Raman spectroscopy can accurately detect basal cell carcinoma (BCC) from surrounding normal tissue; however, the biophysical basis of the detection remained unclear. Read More

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http://dx.doi.org/10.1364/BOE.10.000104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363200PMC
January 2019
1 Read
3.648 Impact Factor

Bowen disease with invasive mucin-secreting sweat gland differentiation: Report of a case and review of the literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Central Zone (Halifax), Halifax, Nova Scotia, Canada.

Bowen disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically, these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. Read More

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http://dx.doi.org/10.1111/cup.13437DOI Listing
February 2019
3 Reads

Multiple benign adnexal tumours: Anything but benign.

Australas J Dermatol 2019 Jan 22. Epub 2019 Jan 22.

St Vincent's Hospital, Sydney, New South Wales, Australia.

Muir Torre syndrome is an autosomal dominant disorder characterised by germline mutations in mismatch repair genes involved in DNA repair, leading to microsatellite instability and a propensity to tumour formation. We report a case of a 67-year-old gentleman who underwent biopsy of a smooth nodular lesion on the nasal tip, histopathologically consistent with sebaceous adenoma. Immunohistochemistry suggested a loss of MSH6. Read More

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http://doi.wiley.com/10.1111/ajd.12989
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http://dx.doi.org/10.1111/ajd.12989DOI Listing
January 2019
21 Reads

HMG-CoA reductase expression in human eyelid tissue and in a human meibomian gland epithelial cell line.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 21;257(4):785-790. Epub 2019 Jan 21.

Save Sight Institute, University of Sydney, Sydney Eye Hospital Campus, 8 Macquarie Street, Sydney, NSW, 2000, Australia.

Purpose: 3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme of cholesterol production, has been found to contribute to lipid secretion from skin sebaceous glands and hair follicles. We assessed for HMGCR expression in human eyelid tissue and in immortalized human meibomian gland epithelial cells (HMGECs) using immunohistochemistry.

Methods: Full thickness human eyelid specimens in archival paraffin blocks were obtained. Read More

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http://dx.doi.org/10.1007/s00417-019-04247-9DOI Listing
April 2019
15 Reads

Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors.

J Dermatol 2019 Mar 21;46(3):249-258. Epub 2019 Jan 21.

Institute for Hematopathology, Hamburg, Germany.

The histogenesis of extraocular sebaceous carcinomas is - in contrast to ocular sebaceous carcinomas - unclear, and information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce. This study attempts to elucidate the histogenesis of sebaceous tumors, using multicolor immunofluorescence stainings to analyze 21 cases of sebaceous tumors (six each of extraocular sebaceous carcinoma, sebaceous adenoma and sebaceoma, and three cases of steatocystomas) and eight cases of normal sebaceous glands for p63, several keratins, androgen receptor, adipophilin, epithelial membrane antigen (EMA) and Ki-67. The data of this observational study provide evidence for the existence of two subpopulations of progenitors in normal sebaceous glands: (i) p63 K5 progenitors which generate the K10 luminal cells of sebaceous ducts; and (ii) p63 K5 K7 progenitors which finally generate K7 adipophilin EMA sebocytes. Read More

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http://dx.doi.org/10.1111/1346-8138.14765DOI Listing
March 2019
7 Reads

Cytokeratin expression in epidermal stem cells in skin adnexal tumors.

Oncol Lett 2019 Jan 8;17(1):927-932. Epub 2018 Nov 8.

Department of Pathology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China.

The expression levels of seven types of cytokeratin (CK) in different kinds of skin adnexal tumors were evaluated. One hundred and thirty-two patients with different kinds of skin adnexal tumors admitted and treated in the Department of Dermatology of Dongying People's Hospital from May 2013 to May 2015 were selected and underwent tissue section staining. Another 20 cases of normal skin were enrolled as the control group. Read More

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http://dx.doi.org/10.3892/ol.2018.9679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312935PMC
January 2019
2 Reads

Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature.

World J Clin Cases 2018 Dec;6(16):1194-1198

Departments of Radiation Oncology, Dankook University Hospital, Dankook University College of Medicine, Cheonan 31116, South Korea.

Background: Primary sebaceous carcinoma of lacrimal gland (SCLG) is extremely rare. Due to its clinical characteristics, it is often misdiagnosed. It is known to be aggressive so delay in diagnosis can increase the chance of local recurrence and metastasis. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i16.1194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306633PMC
December 2018
3 Reads

Periocular Sebaceous Carcinoma With Apocrine Differentiation: A Case Report and Review of the Literature.

Int J Surg Pathol 2018 Dec 6:1066896918816806. Epub 2018 Dec 6.

1 Centro Hospitalar São João, Porto, Portugal.

A 61-year-old man presented with a dome-shaped tumor in the right eyelid. Histology revealed a cutaneous neoplasm with lobular growth pattern. It was composed of large basaloid cells, cells with sebaceous differentiation, and glandular structures with apocrine features. Read More

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http://dx.doi.org/10.1177/1066896918816806DOI Listing
December 2018
3 Reads

Malignant eyelid tumors: Are intra-operative rapid frozen section and permanent section diagnoses of surgical margins concordant?

Int Ophthalmol 2018 Dec 8. Epub 2018 Dec 8.

Ophthalmic Pathology Laboratory (DKM), L V Prasad Eye Institute, Hyderabad, India.

Purpose: To study the concordance between intra-operative rapid frozen section and permanent section diagnoses of surgical margins following wide surgical excisional biopsy of malignant eyelid tumors.

Methods: This is a retrospective study of 120 cases and 429 frozen section slides.

Results: Of 120 cases, 75 (63%) had sebaceous gland carcinoma, 34 (28%) had basal cell carcinoma, and 11 (9%) had squamous cell carcinoma. Read More

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http://dx.doi.org/10.1007/s10792-018-1058-0DOI Listing
December 2018
4 Reads

Immunoreactivity for Sox10 in Basaloid Neoplasms of The Skin.

Appl Immunohistochem Mol Morphol 2019 Feb;27(2):114-118

Section of Dermatopathology, Division of Surgical Pathology-Cytopathology, University of Virginia Medical Center, Charlottesville, VA.

Basaloid tumors of the skin pose a diagnostic challenge to pathologists, because the differential diagnosis is broad, sometimes with subtle differentiating features. We evaluated SOX10 expression in 120 primary cutaneous tumors with epidermal, sweat glandular, neuroendocrine/neuroectodermal, follicular, and sebaceous lineages. Our findings were compared with those of previous studies that evaluated SOX10 in tumors of the skin. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000721DOI Listing
February 2019
3 Reads

Identification and regulation pattern analysis of long noncoding RNAs in meibomian gland carcinoma.

Epigenomics 2019 Feb 7;11(4):381-400. Epub 2018 Dec 7.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China.

Aim: To identify long noncoding RNAs (lncRNAs) and to elucidate regulation patterns of lncRNAs in meibomian gland carcinoma (MGC).

Materials & Methods: We used RNA-Seq, gene ontology, ClueGO, Ingenuity Pathway Analysis and co-expression network analyses to profile the expression and regulation patterns of lncRNAs and mRNAs in MGC.

Results: We identified 500 lncRNAs and 326 mRNAs as differentially expressed. Read More

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http://dx.doi.org/10.2217/epi-2018-0182DOI Listing
February 2019
5 Reads

Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma.

Pathology 2019 Jan 28;51(1):67-73. Epub 2018 Nov 28.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Hong Kong. Electronic address:

Malignant transformation of benign mature ovarian teratoma can result in a wide spectrum of cancer, including a variety of carcinoma, sarcoma, or melanoma. The role of mismatch repair defects in such malignant transformation is still elusive. In view of current immunotherapy, the role of mismatch repair deficiency can have significant implications on therapeutic strategy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183034
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http://dx.doi.org/10.1016/j.pathol.2018.09.061DOI Listing
January 2019
14 Reads

Clinicopathological characteristics of breast sebaceous adenocarcinoma.

Pol J Pathol 2018;69(3):226-233

Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. Read More

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http://dx.doi.org/10.5114/pjp.2018.79542DOI Listing
January 2018
4 Reads

Primary cutaneous apocrine carcinoma arising within a nevus sebaceus.

Cutis 2018 Oct;102(4):291-294

Nova Southeastern University College of Osteopathic Medicine/Largo Medical Center, Florida, USA.

Nevus sebaceus (NS)(organoid nevus) is a benign follicular neoplasm that commonly occurs on the scalp, face, or neck. With time, it may give rise to benign or malignant tumors such as trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma (BCC). Rarely, other types of neoplasms may develop. Read More

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October 2018
11 Reads

Lamellar rotation surgery: a new procedure for repairing upper eyelid defects.

Authors:
Qingji Li

BMC Ophthalmol 2018 Nov 7;18(1):291. Epub 2018 Nov 7.

Department of Oculoplastic and Reconstructive Surgery, Tianjin Aier Eye Hospital, No.102, Fukang Road, Nankai District, Tianjin, 300190, People's Republic of China.

Background: To report "Lamellar Rotation Surgery",a new technique for repairing large and moderate full-thickness upper eyelid defects.

Methods: A two-stage technique is described in which a vertical incision is made in the tarsus of the lower eyelid with elevation of the lateral posterior lamella while sparing the lower eyelid orbicularis and skin to be rotated superiorly to form the reconstructed posterior lamella of the upper eyelid. Additionally, a lateral periosteal flap is used to reconstruct the lateral canthal tendon, and a McGregor procedure is used to reconstruct the anterior lamella of the upper eyelid. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0958-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222999PMC
November 2018
16 Reads

Malignant Transformation of Mature Cystic Teratoma: Is Squamous Cell Carcinoma Different From the Other Types of Neoplasm?

Int J Gynecol Cancer 2018 11;28(9):1650-1656

Department of Obstetrics and Gynecology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.

Objectives: Malignant transformation of mature cystic teratoma (MCT) is rare. Unlike squamous cell carcinoma (SCC) in MCT, the other types of neoplasm in MCT have not been discussed in publications. We analyzed the clinical characteristics and prognosis of the other types of neoplasm (non-SCC) compared with those of SCC. Read More

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http://dx.doi.org/10.1097/IGC.0000000000001375DOI Listing
November 2018
18 Reads

A Case Report of Recurrent Metastatic Sebaceous Carcinoma Which Showed Favorable Response Tt Non-Fluorouracil Based Chemotherapy.

Am J Case Rep 2018 Oct 6;19:1192-1196. Epub 2018 Oct 6.

Division of Hematology-Oncology, Department of Internal Medicine, Daejeon Sun Medical Center,, Daejeon, South Korea.

BACKGROUND Sebaceous carcinoma is a rare malignant tumor of the skin adnexa. While surgical resection is a treatment of choice in localized disease, frequent recurrence and distant metastasis make treatment difficult. Moreover, due to its rarity, optimal systemic treatment has not been determined. Read More

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http://dx.doi.org/10.12659/AJCR.912552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187987PMC
October 2018
3 Reads

Contemporary update of overall prognosis and nomogram to predict individualized survival for Chinese patients with eyelid sebaceous carcinoma.

EBioMedicine 2018 Oct 17;36:221-228. Epub 2018 Sep 17.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.. Electronic address:

Background: The prognosis of Chinese patients with eyelid sebaceous carcinoma (SC) has not been updated for >3 decades. The prognostic predictors are multifactorial, and there is no validated prognostic model for eyelid SC.

Methods: This study included 238 consecutive patients with eyelid SC. Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197575PMC
October 2018
2 Reads

Clinical and ophthalmological outcome of endoscopic transorbital surgery for cranioorbital tumors.

J Neurosurg 2018 Sep 1:1-9. Epub 2018 Sep 1.

4Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine; and.

OBJECTIVECranioorbital tumors are complex lesions that involve the deep orbit, floor of the frontal bone, and lesser and greater wing of the sphenoid bone. The purpose of this study was to describe the clinical and ophthalmological outcomes with an endoscopic transorbital approach (TOA) in the management of cranioorbital tumors involving the deep orbit and intracranial compartment.METHODSThe authors performed endoscopic TOAs via the superior eyelid crease incision in 18 patients (16 TOA alone and 2 TOA combined with a simultaneous endonasal endoscopic resection) with cranioorbital tumors from September 2016 to November 2017. Read More

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http://dx.doi.org/10.3171/2018.3.JNS173233DOI Listing
September 2018
13 Reads

Dermoscopy of Adnexal Tumors.

Dermatol Clin 2018 Oct 16;36(4):397-412. Epub 2018 Aug 16.

Dermatology Department, Hospital General Universitario de Alicante, ISABIAL, C/Maestro Alonso 109, 03010 Alicante, Spain.

Cutaneous adnexal tumors include lesions with apocrine, eccrine, follicular, sebaceous, and mixed differentiation. Most are benign and sporadic, although malignant forms are occasionally observed and some cases develop in the setting of inherited syndromes. These tumors often cause immense diagnostic difficulty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183107
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http://dx.doi.org/10.1016/j.det.2018.05.007DOI Listing
October 2018
26 Reads

Expression of hormone receptors, adipophilin, and GCDFP-15 in mucinous carcinoma of the skin.

J Cutan Pathol 2018 Dec 4;45(12):886-890. Epub 2018 Oct 4.

Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Background: Primary cutaneous mucinous carcinoma (PCMC) is a rare epithelial tumor with unclear histogenesis.

Methods: We evaluated the immunohistochemical expression of the estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR) in six cases of PCMC. The immunoreactivity of adipophilin and gross cystic disease fluid protein (GCDFP)-15 was investigated to determine the origin of the tumor. Read More

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http://dx.doi.org/10.1111/cup.13349DOI Listing
December 2018
2 Reads

Comparison of posterior lamellar resection versus lumpectomy for initial management of localized tarsal conjunctival sebaceous carcinoma in 54 cases.

Indian J Ophthalmol 2018 09;66(9):1295-1300

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose: Comparison of outcomes of localized eyelid sebaceous carcinoma (American Joint Committee on Cancer (AJCC) 8 edition categories T1, T2, T3) following initial management with posterior lamellar resection (PLR) versus (vs) lumpectomy (nonposterior lamellar resection, non-PLR).

Methods: This was a retrospective, comparative, interventional case series. Of 54 patients, 26 were managed by PLR and 28 by nonPLR. Read More

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http://dx.doi.org/10.4103/ijo.IJO_239_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113834PMC
September 2018
4 Reads

Sebaceous gland carcinoma: Can we do better?

Indian J Ophthalmol 2018 09;66(9):1235-1237

Editor, Indian Journal of Ophthalmology, Editorial Office: Centre for Sight, Road No 2, Banjara Hills, Hyderabad - 500 034, Telangana, India.

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http://dx.doi.org/10.4103/ijo.IJO_1370_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113820PMC
September 2018
2 Reads

[Dermatofibroma with sebaceous induction].

Ann Dermatol Venereol 2018 Oct 7;145(10):613-619. Epub 2018 Aug 7.

Cabinet de pathologie cutanée, 56, rue de la Roquette, 75011 Paris, France.

Background: Histiocytoma or dermatofibroma (DF) is a common benign skin tumour with several clinical and histopathological variants. Sebaceous induction overlying a dermatofibroma is rare and infrequently reported. Using a detailed clinical case, herein the semiological and dermoscopic features of this lesion are described and illustrated, and the differential diagnoses presented. Read More

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http://dx.doi.org/10.1016/j.annder.2018.04.011DOI Listing
October 2018
4 Reads

Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid.

Int Ophthalmol 2018 Jul 19. Epub 2018 Jul 19.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630, Sugitani, Toyama, 930-0194, Japan.

Purpose: This study aimed to evaluate the relationships between androgen receptor (AR) expression and clinicopathologic features of sebaceous gland carcinoma (SGC) of the eyelid.

Methods: AR expression was evaluated via immunohistochemistry analysis of surgically derived samples from 11 patients with SGC of the eyelid.

Results: The expression of AR was evident in 9 of 11 patients (82%). Read More

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http://dx.doi.org/10.1007/s10792-018-0990-3DOI Listing
July 2018
2 Reads

[Establishment of standardized diagnosis and treatment of eyelid sebaceous carcinoma in China].

Authors:
D M Li

Zhonghua Yan Ke Za Zhi 2018 Jul;54(7):481-483

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing 100730, China.

Eyelid sebaceous carcinoma is a malignant tumor originating from Meibomian glands, Zeis glands, and other glands surrounding hair follicles. It is the second most common eyelid malignancy, following basal cell carcinoma, in China. Considering its diversified clinical manifestations and strong tendency for recurrence and metastasis, standardized cancer staging, surgical excision with frozen section control, and postsurgical follow-up has been internationally adopted with the aim to considerably reduce the risk of recurrence and metastasis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.07.001DOI Listing
July 2018
11 Reads

Current review of sebaceous cell carcinoma.

Curr Opin Ophthalmol 2018 Sep;29(5):445-450

Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY.

Purpose Of Review: Periocular sebaceous cell carcinoma is a rare malignancy that is often misdiagnosed leading to increased morbidity and mortality. This review aims to describe current knowledge on the disease to aid clinicians in timely diagnosis and treatment.

Recent Findings: New research has shown that the diagnosis of sebaceous cell carcinoma can be aided with immunohistochemical stains. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000505DOI Listing
September 2018
7 Reads

Carboplatin and Pembrolizumab Chemoimmunotherapy Achieves Remission in Recurrent, Metastatic Sebaceous Carcinoma.

Ophthalmic Plast Reconstr Surg 2018 Sep/Oct;34(5):e149-e151

Ophthalmic Consultants of Vermont, South Burlington, Vermont, U.S.A.

A 72-year-old Caucasian woman who had recurrent sebaceous carcinoma of the right orbit with bilateral cervical lymph node involvement 24 months after orbital exenteration was treated with carboplatin (area under the curve of 5) and pembrolizumab (2 mg/kg) for 6 cycles, followed by maintenance pembrolizumab. She obtained a complete pathological remission and remains free of local, regional, and systemic disease at 15 months. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001164DOI Listing
September 2018
7 Reads

Endocrine mucin-producing sweat gland carcinoma of the eyelid: A clinical and histological conundrum.

Indian J Ophthalmol 2018 07;66(7):1042-1044

Department of Ophthalmic Plastic Surgery & Ocular Oncology Services, Orbit Eye Hospital, Mumbai, Maharashtra, India.

A 60-year-old male presented with a 6-month-old history of a left upper lid mass. The mass was excised, and histopathological evaluation showed a well-circumscribed, multinodular, intradermal tumor consisting of round-to-oval cells with round nuclei and mucin filled cysts. On immunohistochemical analysis, the tumor cells stained positively for cytokeratin (CK)-7, CK-8, estrogen receptor (ER), progesterone receptor (PR), mucicarmine, synaptophysin, gross cystic disease fluid protein-15 (GCDFP-15), and neuron-specific enolase (NSE). Read More

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http://dx.doi.org/10.4103/ijo.IJO_36_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032758PMC
July 2018
20 Reads

Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases.

Histopathology 2018 Oct 9;73(4):585-592. Epub 2018 Jul 9.

Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.

Aims: Sebaceous carcinomas are uncommon malignant cutaneous tumours originating from the pilosebaceous unit. Although its occurrence is mostly common in peri-ocular glands, other anatomical regions of the head and neck may be affected, including major and minor salivary glands.

Methods And Results: We describe a series of sebaceous adenocarcinomas of the parotid and submandibular glands. Read More

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http://dx.doi.org/10.1111/his.13664DOI Listing
October 2018
4 Reads

Eyelid sebaceous carcinoma in situ presenting as haemorrhagic cyst.

Australas J Dermatol 2018 Nov 23;59(4):e310-e311. Epub 2018 May 23.

South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1111/ajd.12855DOI Listing
November 2018
27 Reads

MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma.

Sci Rep 2018 May 14;8(1):7531. Epub 2018 May 14.

Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, UK.

Sebaceous gland carcinoma (SGC) is a rare, but life-threatening condition with a predilection for the periocular region. Eyelid SGC can be broadly categorised into two subtypes, namely either nodular or pagetoid with the latter being more aggressive and requiring radical excision to save life. We have identified key altered microRNAs (miRNA) involved in SGC shared by both subtypes, hsa-miR-34a-5p and hsa-miR-16-5p. Read More

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http://dx.doi.org/10.1038/s41598-018-25900-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951834PMC
May 2018
11 Reads

Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma.

Nat Commun 2018 05 14;9(1):1894. Epub 2018 May 14.

Department of Dermatology, University of California, San Francisco, CA, 94115, USA.

Sebaceous carcinomas (SeC) are cutaneous malignancies that, in rare cases, metastasize and prove fatal. Here we report whole-exome sequencing on 32 SeC, revealing distinct mutational classes that explain both cancer ontogeny and clinical course. A UV-damage signature predominates in 10/32 samples, while nine show microsatellite instability (MSI) profiles. Read More

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http://dx.doi.org/10.1038/s41467-018-04008-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951856PMC
May 2018
16 Reads
10.740 Impact Factor

Ocular sebaceous gland carcinoma: an update of the literature.

Int Ophthalmol 2018 Apr 25. Epub 2018 Apr 25.

The Operation Eyesight, Universal Institute for Eye Cancer (MVC, SK), L V Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To review and summarize the newest update on ocular sebaceous gland carcinoma (SGC) focusing on diagnosis and treatment.

Methods: A PubMed search was carried out using the terms "Sebaceous Carcinoma", "Meibomian Gland Carcinoma", "Sebaceous Cell Carcinoma", and "Sebaceous Gland Carcinoma". All studies published in English up to October 2017 were included in this review. Read More

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http://dx.doi.org/10.1007/s10792-018-0925-zDOI Listing
April 2018
3 Reads

Cutaneous Metastasis Leading to the Diagnosis of Carcinoma of the Prostate: A Rare Case Report and Review of Literature.

Indian J Dermatol 2018 Mar-Apr;63(2):182-185

Department of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat, India.

Prostate adenocarcinoma is a common urologic malignant neoplasm in man. Distant cutaneous metastases (CMs) of prostate carcinoma are extremely rare with a reported incidence of 0.36% and usually they occur late. Read More

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http://dx.doi.org/10.4103/ijd.IJD_7_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903053PMC
April 2018
6 Reads

Intraoperative Adjunctive Mitomycin C and Cryotherapy for Recurrent Conjunctival Papillary Sebaceous Carcinoma.

Case Rep Ophthalmol 2018 Jan-Apr;9(1):221-226. Epub 2018 Mar 22.

Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Purpose: To report a case of recurrent conjunctival papillary sebaceous carcinoma that was successfully treated by a combination of surgical resection, intraoperative topical mitomycin C application, and cryotherapy.

Observations: A woman in her 80s developed a yellowish papillary tumor pedunculated from the surface of the upper palpebral tarsal conjunctiva in her left eye. She was histopathologically diagnosed as having sebaceous carcinoma by an excisional biopsy. Read More

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http://dx.doi.org/10.1159/000487704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903128PMC
March 2018
6 Reads

Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the Milan System for Reporting Salivary Gland Cytopathology.

Cancer Cytopathol 2018 Jul 18;126(7):490-497. Epub 2018 Apr 18.

Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona.

Background: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. Read More

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http://dx.doi.org/10.1002/cncy.22002DOI Listing
July 2018
7 Reads

Impact of Muir-Torre Syndrome on Survival in Patients With Sebaceous Carcinoma: A SEER Population-Based Study.

Dermatol Surg 2019 01;45(1):148-149

Department of Dermatology Case Western Reserve University School of Medicine, Cleveland, Ohio Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

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http://dx.doi.org/10.1097/DSS.0000000000001503DOI Listing
January 2019
6 Reads

Sebaceous carcinoma of the breast in a patient with a pathogenic BRCA2 (886delGT) mutation - focus on histopathologic and immunohistochemical features.

APMIS 2018 Apr;126(4):353-356

Department of Pathology, Chicago Medical School, North Chicago, IL, USA.

Sebaceous carcinoma of the breast (SCB) is a rare variant of ductal carcinoma arising within the mammary gland and containing at least 50% of malignant cells with sebaceous differentiation. Only 11 cases that adjust to the criteria delineated in the WHO classification have been published in the English literature, to the best of our knowledge. Here, we present the first SCB arising in the context of a deleterious BRCA2 mutation, focusing on the histopathologic and immunohistochemical features of this exceedingly rare tumor. Read More

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http://dx.doi.org/10.1111/apm.12826DOI Listing
April 2018
5 Reads

Eyelid sebaceous gland carcinoma: Varied presentations and reconstruction outcome.

Oman J Ophthalmol 2018 Jan-Apr;11(1):21-27

Department of Pathology, Jawaharlal Nehru Medical College, AMU, Aligarh, Uttar Pradesh, India.

Purpose: To analyze varying clinical presentations, histopathological features, and management outcome of sebaceous gland carcinoma (SGC) of the eyelid.

Materials And Methods: We retrospectively reviewed medical records of 30 patients with histologically proven cases of SGC of eyelid treated at tertiary care hospital.

Results: Patients were in the age group of 28-80 years, among which 18 (60%) were females and 12 (40%) were males. Read More

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http://dx.doi.org/10.4103/ojo.OJO_139_2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848342PMC
March 2018
9 Reads

Breast sebaceous carcinoma-a rare entity. Clinico-pathological description of two cases and brief review.

Virchows Arch 2018 May 19;472(5):877-880. Epub 2018 Mar 19.

Department of Pathology, Centro Hospitalar São João, Porto, Portugal.

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http://dx.doi.org/10.1007/s00428-018-2327-zDOI Listing
May 2018
4 Reads

Largest case series of Latin American eyelid tumors over 13-Years from a single center in Sao Paulo, Brazil.

Arq Bras Oftalmol 2018 Jan-Feb;81(1):7-11

Department of Ophthalmology and Visual Sciences, Ocular Oncology Service, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: Malignant lesions of the eyelid are the most common eye cancers. Although rarely lethal, late diagnosis can lead to serious visual morbidity. Definitive diagnosis of neoplastic lesions is pathological. Read More

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http://dx.doi.org/10.5935/0004-2749.20180004DOI Listing
October 2018
8 Reads

Keratinizing pleomorphic adenoma: An unusual case report.

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S69-S72

Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.

Pleomorphic adenoma (PA) is the most common benign tumor of major or minor salivary glands. PA exhibits a great histological diversity, such as differentiation into oncocytic, sebaceous, mucinous, squamous, chondroid, osseous or adipose cells. Squamous metaplasia rarely results in the formation of extensive keratin-filled cyst lined by squamous epithelium. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_200_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824522PMC
January 2018
8 Reads

Immunohistochemical evaluation of stress-responsive protein sestrin2 and its correlation with p53 mutational status in eyelid sebaceous gland carcinoma.

Br J Ophthalmol 2018 06 24;102(6):848-854. Epub 2018 Feb 24.

Department of Zoology, Sri Venkateswara College, University of Delhi, New Delhi, India.

Background: p53 is a stress-activated tumour suppressor gene, and its mutation has been associated with solid tumours including non-melanoma skin cancers. Sestrin2 expression is associated with DNA damage and oxidative stress and has been described as a downstream target of p53 network. However, its role in sebaceous gland carcinoma (SGC) remains unexplored. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2017-311283DOI Listing
June 2018
16 Reads