1,605 results match your criteria Sebaceous Gland Carcinoma


Metastatic Prostatic Adenocarcinoma in Patient With Muir-Torre Syndrome Misdiagnosed as Metastatic Sebaceous Carcinoma: Case Report and Systematic Literature Review.

Am J Dermatopathol 2020 Jun 5. Epub 2020 Jun 5.

Department of Pathology, McGill University Health Centre, Montreal, Québec, Canada.

Muir-Torre syndrome (MTS) is a rare autosomal dominant condition characterized by the presence of at least one cutaneous sebaceous tumor and one visceral malignancy, arising mostly from the gastrointestinal tract. We present the case of a 63-year-old man with several cutaneous and visceral neoplasias in the context of MTS, and a pelvic lymph node lesion diagnosed initially as metastatic sebaceous carcinoma, but later identified as metastasis from a newly diagnosed prostatic adenocarcinoma. Histological similarities between these 2 lesions are discussed. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001633DOI Listing

Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors.

Am J Dermatopathol 2020 Jun 15. Epub 2020 Jun 15.

Gerhard-Domagk-Institute of Pathology, University of Muenster, Münster, Germany.

Extraocular sebaceous carcinoma (ESC) is a rare appendiceal skin tumor. In contrast to ocular sebaceous carcinoma, information about the exact cellular architecture of these lesions is scarce and the histogenesis of ESC is unknown. Here, we extend our previous study and investigate 28 extraocular carcinomas in comparison to 54 benign sebaceous tumors and 8 cases of normal sebaceous glands using a broad spectrum of antibodies against p63, several keratins, adipophilin, EMA, Ki67, androgen receptor, and mismatch repair proteins. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001667DOI Listing

Eyelid sebaceous gland carcinoma: An assessment of the T classification of the American Joint Committee of Cancer TNM staging system 8th versus 7th edition.

Eur J Ophthalmol 2020 Jun 21:1120672120936488. Epub 2020 Jun 21.

King Khaled Eye Specialist Hospital- KKESH- Riyadh, Saudi Arabia.

Purpose: To assess the prognostic values of the T classification of the 8th edition of the American Joint Committee of Cancer staging system and compare it to the 7th edition.

Methods: Multicenter retrospective study of patients with eyelid sebaceous gland carcinoma. The primary outcome measure was the differences between outcomes when tumors were staged with either 7th or 8th edition. Read More

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http://dx.doi.org/10.1177/1120672120936488DOI Listing

Nationwide Trends in the Incidence and Survival of Eyelid Skin Cancers in Korea.

Ophthalmic Epidemiol 2020 Jun 2:1-11. Epub 2020 Jun 2.

Division of Cancer Registration and Surveillance, National Cancer Center , Goyang, Republic of Korea.

Purpose: This study provides a population-based report on eyelid skin cancer epidemiology showing trends in its incidence and survival in South Korea.

Methods: For this population-based epidemiological study, nationwide cancer incidence data were obtained from the Korea Central Cancer Registry, covering the entire population. Age-standardised incidence rates (ASRs) and annual per cent changes (APCs) were calculated according to sex, histological types, stage, and date of diagnosis. Read More

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http://dx.doi.org/10.1080/09286586.2020.1767152DOI Listing

Risk of rare cancers among solid organ transplant recipients.

J Natl Cancer Inst 2020 May 27. Epub 2020 May 27.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

Background: Immunosuppressed solid organ transplant recipients [SOTRs] have elevated rates of certain rare cancers caused by viruses. Evaluating risk of rare cancers among SOTRs may provide etiological clues for additional cancers linked to poor immunity and viral infections.

Methods: We performed a cohort study of 262,455 SOTRs (1987-2014) from the US SOTR registry linked to 17 population-based cancer registries. Read More

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http://dx.doi.org/10.1093/jnci/djaa078DOI Listing

Dermoscopic features and differential diagnosis of sebaceous carcinoma.

J Dermatol 2020 Jul 16;47(7):755-762. Epub 2020 May 16.

Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan.

Sebaceous carcinoma is a rare malignant skin neoplasm arising from sebaceous glands. Its clinical diagnosis is difficult and reports of dermoscopic findings have been limited. This study aims to analyze its dermoscopic features and differential diagnosis in dermoscopic examination. Read More

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http://dx.doi.org/10.1111/1346-8138.15384DOI Listing

Misdiagnosis of sebaceous carcinoma.

Acta Chir Belg 2020 May 19:1-6. Epub 2020 May 19.

Department of Plastic Surgery, ZNA Middelheim Hospital, Antwerp, Belgium.

Sebaceous carcinoma is an aggressive malignant tumour. To prevent mutilating surgery and improve patient outcomes, early diagnosis and prompt treatment are necessary. When the tumour invades surrounding tissues, treatment may become complex. Read More

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http://dx.doi.org/10.1080/00015458.2020.1765674DOI Listing

Ocular Sebaceous Carcinoma In Situ With Biphenotypic Differentiation: A Reappraisal of the Alternative Origin of the Tumor.

Int J Surg Pathol 2020 May 4:1066896920917445. Epub 2020 May 4.

Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China.

Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with no invasive carcinoma in the underlying sebaceous glands. Early stromal invasion was identified that featured 2 distinctive but focally intermixed populations of sebaceous carcinoma cells and squamous carcinoma cells. Read More

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http://dx.doi.org/10.1177/1066896920917445DOI Listing

Detection of Epstein-Barr Virus in 130 Cases of Eyelid Sebaceous Gland Carcinoma Using In Situ Hybridization.

J Ophthalmol 2020 30;2020:7354275. Epub 2020 Mar 30.

Department of Ocular Pathology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China.

Purpose: In this study, we aimed to investigate the presence of Epstein-Barr virus (EBV) in the eyelid sebaceous gland carcinoma (SGC) and its association with the clinicopathologic features.

Methods: One hundred and thirty paraffin-embedded SGC specimens were retrieved from the Clinical Pathology Department of Zhongshan Ophthalmic Center. Epstein-Barr virus-encoded RNA (EBER) was detected with in situ hybridization (ISH) using the Leica BOND system autostainer. Read More

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http://dx.doi.org/10.1155/2020/7354275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152957PMC

Prognostic significance of immune checkpoints in the tumour-stromal microenvironment of sebaceous gland carcinoma.

Br J Ophthalmol 2020 Apr 10. Epub 2020 Apr 10.

Ocular Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India

Background: Immune checkpoint blockade strategies have gained attention in the treatment/prognosis of cancers by targeting the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway alone or in combination with cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) blockade and are currently in clinical trials. The present study investigated the expression of the PD-1, PD-L1, CTLA-4, CD4 and CD8 proteins and their prognostic value in the tumour microenvironment of sebaceous gland carcinoma (SGC).

Methods: The expression levels of PD-1, PD-L1, CTLA-4, CD4 and CD8 proteins were assessed in 52 cases of SGC by immunohistochemistry and validated by western blotting. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315490DOI Listing
April 2020
2.976 Impact Factor

Comprehensive germline mutation analysis and clinical profile in a large cohort of Brazilian xeroderma pigmentosum patients.

J Eur Acad Dermatol Venereol 2020 Apr 1. Epub 2020 Apr 1.

Centro de Oncologia, Hospital Sírio-Libanês, São Paulo, São Paulo, Brazil.

Background: Xeroderma pigmentosum (XP) patients present a high risk of developing skin cancer and other complications at an early age. This disease is characterized by mutations in the genes related to the DNA repair system.

Objectives: To describe the clinical and molecular findings in a cohort of 32 Brazilian individuals who received a clinical diagnosis of XP. Read More

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http://dx.doi.org/10.1111/jdv.16405DOI Listing

Extraocular Sebaceous Carcinoma Presenting As a Nodule over the Zygoma.

Cureus 2020 Feb 3;12(2):e6858. Epub 2020 Feb 3.

Pathology, University of Arkansas for Medical Sciences, Little Rock, USA.

We describe a case of sebaceous carcinoma (SC) in a 75-year-old man who presented with a rapidly growing nodule on the left cheek for four weeks. A 75-year-old man presented with a crusted non-tender nodule on the left cheek that had been present for six months. The nodule showed rapid growth in the four weeks before the visit. Read More

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http://dx.doi.org/10.7759/cureus.6858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053665PMC
February 2020

Concomitant Orbital Tumours: Small Lymphocytic Lymphoma Involving the Lacrimal Gland of a Patient with Clinical Diagnoses of Muir-Torre Syndrome and Extensive Sebaceous Gland Carcinoma of the Ipsilateral Eyelid.

Ocul Oncol Pathol 2020 Jan 5;6(1):15-19. Epub 2019 Jun 5.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom.

Background/aims: We present a case of 2 concomitant tumours, i.e., a sebaceous carcinoma (SC) and a small lymphocytic lymphoma (SLL), in the lacrimal gland of a patient with Muir-Torre syndrome

Methods: Clinical history, orbital examination, diagnostic biopsy, excisional biopsy, and histopathologic analysis were utilized. Read More

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http://dx.doi.org/10.1159/000500161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984142PMC
January 2020

Malignant Transformation of Parotid Gland Non-sebaceous Lymphadenoma: Case Report and Review of Literature.

Head Neck Pathol 2020 Jan 29. Epub 2020 Jan 29.

Department of Otolaryngology & Head and Neck Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Non-sebaceous lymphadenoma is a sporadic benign tumor of salivary glands. Histopathologic and immunohistochemical properties, diagnostic criteria, and theories for the histologic origin of the disease have been defined and well-discussed in the literature. However, none of the cases showed malignant transformation to date. Read More

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http://dx.doi.org/10.1007/s12105-020-01133-3DOI Listing
January 2020

Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.

Diagn Cytopathol 2020 May 22;48(5):424-429. Epub 2020 Jan 22.

Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri.

Background: Sebaceous lymphadenomas and sebaceous lymphadenocarcinomas are uncommon neoplasms occurring predominately within the parotid gland. Cytomorphology of these neoplasms is rarely reported. Occasional reports have discussed the cytomorphological features of these neoplasms but criteria distinguishing sebaceous lymphadenomas from lymphadenocarcinomas have not been described. Read More

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http://dx.doi.org/10.1002/dc.24357DOI Listing

Management of recurrent sebaceous gland carcinoma.

Eye (Lond) 2020 Jan 2. Epub 2020 Jan 2.

Sheffield Ocular Oncology Service, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK.

Objective: To evaluate the incidence and management of recurrent periocular sebaceous gland carcinoma at a tertiary ocular oncology service in the United Kingdom.

Methods: This was a retrospective cohort study of 62 patients with sebaceous gland carcinoma treated between 2004 and 2017. A total of 10 eyes were treated for local recurrence. Read More

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http://dx.doi.org/10.1038/s41433-019-0756-9DOI Listing
January 2020

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review.

Biomed Res Int 2019 22;2019:9869406. Epub 2019 Nov 22.

Department of Otorhinolaryngology-Head and Neck Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.

Myeloid sarcoma (MS) is a rarely encountered extramedullary localized tumor that is composed of immature myeloid cells. We reported an extremely rare case of MS with concurrent bone marrow (BM) involvement that invaded into a preexisting sebaceous lymphadenoma in the parotid gland and neck lymph nodes. Prompted by this case, we also present a literature review of MS invasion into salivary glands. Read More

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http://dx.doi.org/10.1155/2019/9869406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893249PMC

Impact of surgery and adjuvant treatment on the outcome of extraocular sebaceous carcinoma: a systematic review and individual patient's data analysis of 206 cases.

Int J Dermatol 2020 Apr 18;59(4):494-505. Epub 2019 Dec 18.

Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.

Background: Extraocular sebaceous carcinoma (EOSC) is an aggressive malignancy of the sebaceous gland. Surgery is considered the cornerstone of treatment, but there is lack of clarity about extent and adjuvant treatment.

Methods: We conducted a systematic review and analysis of individual patient data of all published cases of EOSC to look into demography, pattern of care, importance of type of surgery, and other adjuvant treatment and survival outcome. Read More

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http://dx.doi.org/10.1111/ijd.14739DOI Listing
April 2020
1.227 Impact Factor

Human papillomavirus in ocular malignant tumours: a study from a tertiary eye care centre in North India.

Can J Ophthalmol 2019 12 16;54(6):688-693. Epub 2019 Apr 16.

Ocular Oncology Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences New Delhi, India.

Objective: The present study aims to detect the presence of human papillomavirus (HPV) in ocular malignant tumours, including retinoblastoma, eyelid squamous cell carcinoma (SCC), and sebaceous gland carcinoma (SGC), in the North Indian population.

Design: Prospective observational non randomized study.

Participants: In this study, 142 prospective cases of ocular malignant tumours (retinoblastoma, SGC, and SCC) were included. Read More

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http://dx.doi.org/10.1016/j.jcjo.2019.03.001DOI Listing
December 2019

A rare giant extraocular, anterior chest wall sebaceous carcinoma.

Int J Surg Case Rep 2020 3;66:110-114. Epub 2019 Dec 3.

Plastic Surgery Department, Sefako Makgatho Health Sciences University, Dr George Mukhari Academic Hospital, Pretoria, South Africa.

Background: Sebaceous carcinoma (SC) is a rare aggressive cutaneous malignant tumour. It accounts for less than 1 % of all cutaneous malignant tumours. Sebaceous carcinomas are divided into ocular and extraocular constituting 75 % and 25 % respectively. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.11.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920317PMC
December 2019
5 Reads

[Does orbital exenteration still has a place in 2019?]

J Fr Ophtalmol 2020 Feb 9;43(2):152-174. Epub 2019 Dec 9.

Service de chirurgie oncologique cervico-faciale, centre Antoine Lacassagne, 06189 Nice, France.

Introduction: Orbital exenteration is a radical anatomically and psychologically disfiguring procedure. It is mostly performed for management of orbital cancers or cancers with orbital involvement. The lack of benefit in terms of overall survival and the development of new molecular therapies (targeted therapies, immunotherapy) in recent years leads us to question its use. Read More

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http://dx.doi.org/10.1016/j.jfo.2019.04.021DOI Listing
February 2020

Sebaceous carcinoma: evidence-based clinical practice guidelines.

Lancet Oncol 2019 12;20(12):e699-e714

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

Sebaceous carcinoma usually occurs in adults older than 60 years, on the eyelid, head and neck, and trunk. In this Review, we present clinical care recommendations for sebaceous carcinoma, which were developed as a result of an expert panel evaluation of the findings of a systematic review. Key conclusions were drawn and recommendations made for diagnosis, first-line treatment, radiotherapy, and post-treatment care. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30673-4DOI Listing
December 2019
5 Reads

Sebaceoma on the scalp simulating a malignant pigmented neoplasia.

An Bras Dermatol 2019 Sep - Oct;94(5):590-593. Epub 2019 Sep 30.

ID - Investigação em Dermatologia, Rio de Janeiro, RJ, Brazil.

The correct identification of pigmented nodular lesions of the scalp is often challenging. Despite the importance of clinical patterns and dermoscopy, important adjuvant tools that are usually helpful, their interpretation sometimes is not clear-cut. Here, the authors discuss a case of sebaceoma mimicking a malignant pigmented neoplasia, with conclusive histopathology. Read More

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http://dx.doi.org/10.1016/j.abd.2019.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857578PMC
December 2019

Basal cell carcinoma arising in nevus sebaceous during pregnancy.

Cutis 2019 Oct;104(4):E21-E23

Department of Dermatology, Saint Louis University, USA.

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October 2019

Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies.

Indian J Ophthalmol 2019 12;67(12):1988-1992

Department of Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: To analyze the diagnostic accuracy of frozen section in orbital and adnexal malignancies.

Methods: A total of 55 cases between January 2006 and December 2011 for which intraoperative frozen section was performed for various orbital and adnexal lesions were included in the study. The frozen section diagnosis was compared with the permanent section diagnosis. Read More

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http://dx.doi.org/10.4103/ijo.IJO_2096_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896554PMC
December 2019

Evaluation of PD-L1 and PD-1 expression in aggressive eyelid sebaceous gland carcinoma and its clinical significance.

Indian J Ophthalmol 2019 12;67(12):1983-1987

Department of Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Eyelid sebaceous gland carcinoma (SGC) is an aggressive but rare malignancy of ocular region. Over-expression of PD-L1 and PD-1 has been demonstrated in a variety of solid tumors including conjunctival melanoma. PD-L1 is an immunoinhibitory molecule that suppresses the effective T cells response against tumor antigen leading to the progression of tumors. Read More

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http://dx.doi.org/10.4103/ijo.IJO_2056_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896547PMC
December 2019

Tumors of the conjunctiva and cornea.

Indian J Ophthalmol 2019 12;67(12):1930-1948

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Tumors of the conjunctiva and cornea comprise a large and varied spectrum of conditions. These tumors are grouped into two major categories of congenital and acquired lesions. The acquired lesions are further subdivided based on origin of the mass into surface epithelial, melanocytic, vascular, fibrous, neural, histiocytic, myxoid, myogenic, lipomatous, lymphoid, leukemic, metastatic and secondary tumors. Read More

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http://dx.doi.org/10.4103/ijo.IJO_2040_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896532PMC
December 2019

Mould-based surface high-dose-rate brachytherapy for eyelid carcinoma.

J Contemp Brachytherapy 2019 Oct 30;11(5):443-448. Epub 2019 Oct 30.

Department of Radiotherapy, IEO European Institute of Oncology IRCCS, Milan, Italy.

Purpose: To evaluate toxicity and clinical outcomes in patients with eyelid tumour treated with contact high-dose-rate brachytherapy (HDR-BT).

Material And Methods: Between April 2010 and August 2017, 10 consecutive patients with tumour of the eyelid underwent contact HDR-BT and custom-made surface mould. Every applicator was manually built using conventional thermoplastic material and standard plastic catheters. Read More

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http://dx.doi.org/10.5114/jcb.2019.88619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854866PMC
October 2019

[A clinicopathological classification analysis of ocular mass lesions in 7 910 cases].

Zhonghua Yan Ke Za Zhi 2019 Nov;55(11):847-853

Department of Ophthalmology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

To investigate the anatomical region, histopathological classification and histogensis distribution of ocular mass lesions in South China. Retrospective cases study. The clinical and pathological data of 7 910 samples with ocular (adnexal) tumors or proliferative lesions which were examined from January 2000 to May 2018 were retrospectively retrieved. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.11.011DOI Listing
November 2019

Cryotherapy to treat benign skin tumours in conscious dogs.

Vet Dermatol 2020 Apr 29;31(2):163-166. Epub 2019 Oct 29.

San Marco Veterinary Clinic and Laboratory, Via Dell'Industria 3, 35030, Veggiano, Italy.

Background: Cryotherapy can be used to treat benign skin lesions without general anaesthesia. This technique has only been described in anaesthetized dogs.

Objective: To describe the feasibility, safety and efficacy of cryotherapy to treat benign skin tumours in conscious dogs. Read More

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http://dx.doi.org/10.1111/vde.12804DOI Listing
April 2020
1 Read

Periocular intraepithelial sebaceous neoplasia: critical appraisal of nomenclature and prognostic importance.

J Clin Pathol 2020 Mar 29;73(3):172-175. Epub 2019 Oct 29.

Dermatopathology, USF Health Morsani College of Medicine, Tampa, Florida, USA

Intraepithelial sebaceous neoplasia in the forms (or subclassification) of pagetoid spread and carcinoma in situ is a common feature of periocular sebaceous carcinoma and is associated with less favourable outcomes. Seminal studies of periocular sebaceous carcinoma in the 1980s indicated that the two patterns of intraepithelial spread had differing influences on prognosis with pagetoid invasion being worse. Later studies reported conflicting results, but careful inspection of those studies revealed considerable variation in what was meant by pagetoid invasion. Read More

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http://dx.doi.org/10.1136/jclinpath-2019-206147DOI Listing

Surgical Treatment of Recurrent Lower Eyelid Sebaceous Gland Carcinoma and Reconstruction with Pedicled Nasolabial and Non-vascularised Buccal Mucosal Flaps.

J Maxillofac Oral Surg 2019 Dec 12;18(4):536-538. Epub 2018 Nov 12.

Kanachur Centre for Craniofacial Anomalies, Mangalore, India.

Introduction: Sebaceous gland carcinoma of the eyelid is an uncommon but highly malignant tumour. Post-tumour excisional defect reconstruction must aim in restoration of function and aesthetics. Prompt diagnosis and adequate treatment is of paramount for successful outcome of disease. Read More

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http://dx.doi.org/10.1007/s12663-018-1171-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795660PMC
December 2019
2 Reads

Angiogenesis in Ocular and Extraocular Sebaceous Carcinoma.

Acta Derm Venereol 2019 Dec;99(13):1270-1274

Department of Dermatology, Venereology and Allergology, University Medical Center, Ruprecht-Karls-University, Im Neuenheimer Feld 440, DE-69120 Heidelberg, Germany.

To shed more light on the pathogenesis of sebaceous carcinoma, we analysed the expression of proteins related to angiogenesis in 18 ocular and 22 extraocular sebaceous carcinomas using a broad panel of immunohistochemical markers. To quantify the expression of D2-40, vascular endothelial growth factor, vascular endothelial growth factor receptor-2 and -3, we calculated a quantification score by considering the percentage of positive tumour cells (0=0%, 1=up to 1%, 2=2-10%, 3=11-50%, and 4=>50%) in relation to the staining intensity (0=negative, 1=low, 2=medium, and 3=strong). Additionally, lymphatic microvessel density in the D2-40 stained sections was counted. Read More

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http://dx.doi.org/10.2340/00015555-3342DOI Listing
December 2019
1 Read

Cytologic Grading of Cutaneous Sebaceous Neoplasms: Does it Help to Differentiate Benign From Malignant?

Am J Dermatopathol 2019 Oct;41(10):722-732

Department of Dermatology, Münster University, Münster, Germany.

Both architectural and cytologic characteristics are used to distinguish benign from malignant sebaceous neoplasms; however, specific cytopathologic features of sebocytes have not been well defined. The authors assessed architectural and cytological features of 63 sebaceous neoplasms [15 sebaceous hyperplasias, 12 sebaceomas, 16 sebaceous adenomas (SA), 14 sebaceous carcinomas (SC), and 6 ocular sebaceous carcinoma (OSC)] to investigate whether cytological grading may facilitate classification of lesions. Among other criteria, nuclear pleomorphism (size, nucleolar appearance, membrane irregularity, crowding, mitoses, and chromatin pattern) was assessed and 3 theoretical nuclear grades established. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001434DOI Listing
October 2019
1 Read

[Creation, implementation and objectives of CARADERM, a national network for rare skin carcinomas - Adnexal neoplasm part].

Ann Dermatol Venereol 2019 Nov 30;146(11):704-710. Epub 2019 Sep 30.

Service de dermatologie, hôpital François-Mitterrand, 4, boulevard Hauterive, 64000 Pau, France.

Introduction: CARADERM is a French national network that includes patients with rare skin adnexal neoplasms. The present paper describes only the adnexal neoplasm part of this network. The primary objective of CARADERM is to improve medical care for malignant skin adnexal neoplasms. Read More

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http://dx.doi.org/10.1016/j.annder.2019.07.006DOI Listing
November 2019
2 Reads

[Woman with a yellow patch on the hairy part of the head].

Ned Tijdschr Geneeskd 2019 10 2;163. Epub 2019 Oct 2.

VieCuri, Venlo.

A 52-year-old woman was referred to a dermatologist with a changed yellowish lesion on her scalp. Histological features were those of a sebaceous naevus with secondary malignant differentiation into superficial and solid basal cell carcinoma. A sebaceous naevus is a benign, congenital, hamartomatous lesion. Read More

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October 2019
1 Read

CDKN2A, CDK1, and CCNE1 overexpression in sebaceous gland carcinoma of eyelid.

Int Ophthalmol 2020 Feb 30;40(2):343-350. Epub 2019 Sep 30.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Purpose: To investigate the overexpression of genes in sebaceous gland carcinoma (SGC) of the eyelid compared to sebaceous adenoma of the eyelid in order to elucidate the molecular mechanism underlying pathogenesis.

Methods: We performed histopathological examination of eyelid tissues surgically removed from four patients diagnosed with SGC (cases 1-3) and sebaceous adenoma (case 4) of the eyelid. Next, we performed global gene expression analysis of surgical tissue samples using a GeneChip system and the Ingenuity Pathways Knowledge Base. Read More

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http://link.springer.com/10.1007/s10792-019-01185-7
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http://dx.doi.org/10.1007/s10792-019-01185-7DOI Listing
February 2020
5 Reads

Intraductal sebaceous papilloma of a meibomian gland: a new entity possibly associated with the MSH6 subtype of the Muir-Torre syndrome.

Surv Ophthalmol 2020 Mar - Apr;65(2):227-238. Epub 2019 Sep 23.

Department of Ophthalmic Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Over several months, a painless, multinodular, non-erythematous swelling of the deep tissues of his left upper eyelid developed in a 63-year-old man. An excisional biopsy with histopathologic evaluation disclosed a unique sebaceous papilloma within a cyst lined by non-keratinizing squamous epithelium that focally displayed a variably thick, superficial, eosinophilic cuticular layer. Immunohistochemical staining demonstrated that the tumor and its epithelial cystic lining had a profile consistent with Meibomian gland duct epithelium. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.09.002DOI Listing
September 2019
2 Reads

What is your diagnosis? Subcutaneous inguinal mass in a Greyhound.

Vet Clin Pathol 2019 Dec 27;48(4):780-782. Epub 2019 Aug 27.

Finn Pathologists, Norfolk, UK.

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http://dx.doi.org/10.1111/vcp.12769DOI Listing
December 2019
2 Reads

[Sebaceous carcinoma in situ in extraocular skin : Case report and discussion of the new entity].

Hautarzt 2020 Jan;71(1):57-62

Institut für Pathologie und Mikrobiologie, Neuromed Campus, Kepler Universitätsklinikum Linz, Linz, Österreich.

Sebaceous carcinoma in situ (SCIS) is a rare intraepidermal neoplasia, mostly occurring on the eyelid and the face. Despite abundant literature on invasive sebaceous carcinoma, there are relatively few articles about SCIS. We report the case of 78-year-old woman suffering from SCIS of the left cheek, presenting as an erythematous skin lesion. Read More

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http://dx.doi.org/10.1007/s00105-019-4464-yDOI Listing
January 2020
2 Reads

Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma.

Virchows Arch 2020 Feb 10;476(2):323-327. Epub 2019 Aug 10.

Institute of Pathology, University Medical Centre Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Our aim was to investigate sebaceous differentiation in thymus tumours and to identify new actionable genomic alterations. To this end we screened 35 normal and 23 hyperplastic thymuses, 127 thymomas and 41 thymic carcinomas for the presence of sebaceous differentiation as defined by morphology and expression of adipophilin and androgen receptor (AR). One primary thymic carcinoma showed morphology of sebaceous carcinomas (keratinizing and foam cells, calcifications, giant cells), a strong expression of adipophilin and AR together with squamous markers. Read More

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http://dx.doi.org/10.1007/s00428-019-02644-3DOI Listing
February 2020
4 Reads

Photodynamic Therapy Assay.

Authors:
Mehmet Varol

Methods Mol Biol 2020 ;2109:241-250

Department of Molecular Biology and Genetics, Faculty of Science, Mugla Sitki Kocman University, Mugla, Turkey.

Photodynamic therapy is a promising, minimally invasive, and clinically approved treatment strategy that destroys the cell components by oxidizing the biological molecules such as nucleic acids, carbohydrates, proteins, and lipids, and leads apoptosis in the cells of the target tissue through the generation of singlet oxygen and reactive oxygen species (ROS) owing to the synergic interactions of a nontoxic photosensitizer, a non-thermal light source, and tissue oxygen. This innovative method has drawn the attention of many scientists and been employed in a wide range of medical fields that covers the treatment of cancer diseases and precancerous dermatological disorders, and the aesthetic and cosmetic practices, including photorejuvenation and treatment of photoaging, hirsutism, facial flat warts, rosacea, acne vulgaris, and sebaceous gland hyperplasia. It was therefore intended to provide an in vitro photodynamic therapy assay protocol on human healthy keratinocytes and epidermoid carcinomas to investigate comparatively the therapeutic and destructive activities of the potent light-sensitive medications. Read More

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http://dx.doi.org/10.1007/7651_2019_260DOI Listing
January 2020
4 Reads

Novel application of anterior segment optical coherence tomography for periocular imaging.

Can J Ophthalmol 2019 08 28;54(4):431-437. Epub 2018 Nov 28.

MUHC-McGill University Ocular Pathology and Translational Research Laboratory.

Objective: This study aims to assess the use of optical coherence tomography (OCT) imaging for periocular skin lesions and to determine which characteristic features of these images can be correlated to histopathology.

Design: This is an ongoing prospective study with Research Ethics Board approval.

Participants: Fifty patients over 18 years old with lesions clinically suspicious of nonmelanoma skin cancer on the periocular region were included in this study. Read More

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http://dx.doi.org/10.1016/j.jcjo.2018.09.007DOI Listing
August 2019
4 Reads
1.299 Impact Factor

Juvenile sclerosing polycystic adenosis cytologically mimicking Warthin tumor.

Diagn Cytopathol 2019 Nov 22;47(11):1208-1212. Epub 2019 Jul 22.

Department of Pathology, University of Yamanashi, 1110 Shimokato, Chūō, Yamanashi, Japan.

Sclerosing polycystic adenosis (SPA) is a rare salivary gland disease. Histologically it resembles a low-grade ductal carcinoma in situ or sclerosing adenosis of the breast, characterized by lobular proliferation of ducts with apocrine cellular features surrounded by fibrosclerotic stroma. Although SPA is typically benign, recurrence is not uncommon, and cases with a malignant component have been documented. Read More

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http://dx.doi.org/10.1002/dc.24283DOI Listing
November 2019
5 Reads

Clinicopathologic Characteristics and Predictors Affecting Survival Outcome of Eyelid Malignancy.

J Craniofac Surg 2019 Jul;30(5):1516-1519

Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

The aim of this study was to determine the clinicopathologic characteristics and evaluate the prognostic factors in eyelid malignancies. This was a retrospective, comparative, case series of 70 patients with eyelid malignancies. The mean age at diagnosis was 72. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005341DOI Listing
July 2019
8 Reads

Surgical Feasibility of Curtler-Beard Reconstruction for Large Upper Eyelid Defect.

J Craniofac Surg 2019 Oct;30(7):2181-2183

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: To report long-term surgical outcomes of Cutler-Beard reconstructive surgery in patients with large full-thickness upper eyelid defects following malignant tumor excision.

Methods: The medical records of 5 consecutive patients with full-thickness upper eyelid defects following tumor resection who underwent Cutler-Beard surgery were reviewed retrospectively between April 2005 and November 2018. Surgical procedure comprises 2 stages: first, complete tumor resection followed by bridged full-thickness lower eyelid advancement flap; second, separation of the closed eyelid with eyelid margin repair 7 to 9 weeks later. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005732DOI Listing
October 2019
12 Reads
0.676 Impact Factor

Mutations in TP53, ZNF750, and RB1 typify ocular sebaceous carcinoma.

J Genet Genomics 2019 06 21;46(6):315-318. Epub 2019 Jun 21.

Department of Pathology, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2019.06.001DOI Listing
June 2019
2 Reads

Radiotherapy for localized sebaceous carcinoma of the eyelid: a retrospective analysis of 83 patients.

J Radiat Res 2019 Oct;60(5):622-629

Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.

The current study retrospectively analyzed the results of radiotherapy for clinically localized sebaceous carcinoma of the eyelid.We reviewed records of 83 patients with histologically confirmed sebaceous carcinoma who were treated radiotherapeutically between 1983 and 2015. Sixty-five patients (78%) were initially treated with radiotherapy of curative intent, while the remaining 18 patients underwent postoperative radiotherapy due to tumor recurrence or positive surgical margins. Read More

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http://dx.doi.org/10.1093/jrr/rrz046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805970PMC
October 2019
4 Reads

[Follow-up of a sebaceous carcinoma of the eyelids: A case report].

J Fr Ophtalmol 2019 10 14;42(8):e355-e357. Epub 2019 Jun 14.

Departement A of Ophthalmology, University Mohamed V Souissi, Rabat, Morocco.

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http://dx.doi.org/10.1016/j.jfo.2019.04.013DOI Listing
October 2019
5 Reads

Sebaceous carcinoma of the caruncle.

J Fr Ophtalmol 2019 10 6;42(8):925-927. Epub 2019 Jun 6.

Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Carrer de Sabino Arana, 1, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jfo.2019.04.014DOI Listing
October 2019
5 Reads