1,674 results match your criteria Sebaceous Gland Carcinoma


Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer.

BMC Cancer 2021 May 13;21(1):547. Epub 2021 May 13.

Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas Gral. José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Ciudad de Buenos Aires, Argentina.

Background: Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species. In this study, we evaluated the in vitro photoactivity of four meso-substituted porphyrins and a porphyrin coupled to a fullerene.

Methods: The cell line employed was the LM3 mammary adenocarcinoma, and the PS with the best photokilling activity was administered to mice bearing the LM3 subcutaneously implanted adenocarcinoma. Read More

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Profile of Ophthalmic Tumors in Adult Nepalese Population in Central Nepal.

Nepal J Ophthalmol 2020 Jul;12(24):270-280

Geta Eye Hospital, Dhangadhi, Nepal.

Introduction: Ophthalmic tumors cover benign and malignant tumors of eyelids, conjunctiva, globe, and orbit. There is limited literature on ophthalmic tumors in Nepal. The objective of the study was to find the relative frequency of various ophthalmic tumors in the adult Nepalese population in Central Nepal. Read More

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Papillary Renal Cell Carcinoma in Lynch/Muir-Torre Syndrome with Germline Pathogenic Variant in and Molecular Analysis: Report of a Case and Review of the Literature.

J Kidney Cancer VHL 2021 21;8(2):8-19. Epub 2021 Apr 21.

Department of Pathology & Immunology.

Lynch syndrome (LS) is an autosomal dominant inherited disorder due to pathogenic variations in the mismatch repair genes, which predisposes to malignancies, most commonly colon and endometrial carcinoma. Muir-Torre syndrome is a subset of LS with cutaneous sebaceous adenoma and keratoacanthoma in addition to the malignancies. Renal cell carcinoma (RCC) in patients with LS is extremely rare. Read More

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Treatment-resistant actinic keratoses are characterized by distinct clinical and histological features.

Ital J Dermatol Venerol 2021 Apr;156(2):213-219

Faculty of Health, University Witten-Herdecke, Witten, Germany.

Background: Actinic keratoses (AK) are generally treated to reduce the risk of progression into invasive cutaneous squamous cell carcinoma (cSCC). However, this risk of transformation is low, and rather than focusing on these lesions, current treatment studies report on complete clearance of AKs in an entire field. This study aimed to investigate treatment-resistant AKs (trAK) after field therapy compared to randomly chosen AKs prior to treatment. Read More

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Sebaceous Gland Carcinoma of Lid: Masquerading as a Recurring Chalazion.

Int J Appl Basic Med Res 2021 Apr-Jun;11(2):117-119. Epub 2021 Apr 8.

Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Recurrent chalazion may be associated with bad lid hygiene but can have clinical changes which lead to the suspicion of a more dangerous entity. Particularly in elderly patients, recurrence of chalazion should be suspected to have carcinomatous changes. We present the case of a 52-year-old woman with presentation of recurrent chalazion which turned out to be sebaceous gland carcinoma of the lid. Read More

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Epidemiological Profile and Clinical Stage at Presentation of Eyelid Malignancies in a Multi-Ethnic Country.

J Craniofac Surg 2021 Mar 25. Epub 2021 Mar 25.

Department of Ophthalmology and Visual Sciences, Division of Ophthalmic Plastic and Reconstructive Surgery, Paulista School of Medicine - EPM, Federal University of S. Paulo - UNIFESP, Sao Paulo, Brazil.

Abstract: Eyelid malignancies are frequently seen in clinical practice. There is a lack of studies that have assessed the features of these lesions in mixed population countries. The epidemiologic profile, clinical stage at presentation, management, and outcomes of patients with eyelid malignancies were assessed, in order to better understand the features of these lesions in a multi-ethnic country. Read More

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Ocular and Periocular Tumors in India: An EyeSmart Electronic Medical Record Analysis of 9633 Cases from a Referral Center.

Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):199-203. Epub 2021 Jan 19.

Department of EyeSmart EMR and AEye (AVD), L V Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To describe the epidemiology of ocular and periocular tumors in patients presenting to a multi-tier ophthalmology hospital network in India using the electronic medical records (EMRs) system.

Methods: A retrospective, observational, referral, hospital-based study of 1,142,098 patients. The data were collected using the in-house developed EyeSmart EMR system. Read More

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Androgen and Estrogen Receptor Expression in Different Types of Perianal Gland Tumors in Male Dogs.

Animals (Basel) 2021 Mar 19;11(3). Epub 2021 Mar 19.

Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-612 Lublin, Poland.

Perianal gland tumors are modified sebaceous glands present in the skin of the perianal region in the dog. Hormonal stimulation may induce hyperplasia of the perianal glands or their neoplastic progression. The presence of androgen (AR) and estrogen (ER) receptors have been demonstrated both in normal perianal glands as well as in perianal tumors. Read More

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Could Extension Into the Lacrimal Gland and Sac Thwart Topical Chemotherapy for Intraepithelial Sebaceous Carcinoma?

Ophthalmic Plast Reconstr Surg 2021 Mar 24. Epub 2021 Mar 24.

Adnexal Service, Moorfields Eye Hospital NHS Foundation Trust Department of Histopathology, Institute of Ophthalmology, London, United Kingdom.

Purpose: To identify the frequency of intraepithelial (Pagetoid) spread beyond the ocular surface-namely beyond conjunctiva and cornea-in patients undergoing orbital exenteration for advanced periocular Sebaceous carcinoma (SC).

Design: A retrospective, noncomparative observational case series.

Subjects: Patients undergoing orbital exenteration for biopsy-proven SC, at Moorfields Eye Hospital between 1997 and 2013. Read More

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A recurrent case of extraocular sebaceous carcinoma with distant organ metastasis.

Arch Craniofac Surg 2021 Feb 20;22(1):56-61. Epub 2021 Feb 20.

Department of Plastic Surgery, Inje University Busan Paik Hospital, Busan, Korea.

Sebaceous carcinoma (SC) is a rare tumor, accounting for approximately 0.7% of skin cancers. SC can be classified as ocular SC (OSC) or extraocular SC (EOSC) depending on its location. Read More

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February 2021

Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy.

Clin Ophthalmol 2021 26;15:871-879. Epub 2021 Feb 26.

Apollo Specialty Hospital, Navi Mumbai, India.

Purpose: To study the level of serum malondialdehyde (MDA), a biomarker of oxidative stress before and after chemotherapy in various ocular malignancies and to correlate its significance with clinicopathological parameters.

Methods: Thirty two histopathologically confirmed cases of primary ocular malignancies were included in this longitudinal cohort study. Detailed clinicopathological assessment was done. Read More

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February 2021

An updated review of the sebaceous gland and its role in health and diseases Part 2: Pathophysiological clinical disorders of sebaceous glands.

Dermatol Ther 2021 03 19;34(2):e14862. Epub 2021 Feb 19.

Veterans Affairs Hospital and SUNY Downstate Dermatology Service, Brooklyn, New York, USA.

Sebaceous glands are sebum-secreting components of pilosebaceous units. In the second of this two-part series, we review the pathologies in which sebaceous glands are primarily and secondarily implicated. They are primarily involved in steatocystoma simplex and multiplex, sebaceous gland hyperplasia, sebaceoma, sebaceous adenoma, sebaceous carcinoma, nevus sebaceus, and folliculosebaceous cystic hamartoma. Read More

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Isolated peripunctal sebaceous gland carcinoma in a young adult: An unusual presentation.

Saudi J Ophthalmol 2020 Jan-Mar;34(1):73-75. Epub 2020 Nov 22.

Ophthalmic Pathology Laboratory, L V Prasad Eye Institute, Kallam Anji Reddy Campus, Road No. 2, Banjara Hills, Hyderabad - 500 034, Telangana, India.

Sebaceous gland carcinoma (SGC) of the eyelid is one of the leading peri-ocular eyelid malignancies in Asian-Indians. It usually affects elderly women and has a high rate of local recurrence, regional and distant metastasis. This is partly attributable to a delay in clinical diagnosis since it mimics more benign conditions of the eyelid like chalazia. Read More

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November 2020

Clinicopathological Analysis and Demographic Features of Ocular Malignancies.

Clin Ophthalmol 2021 29;15:357-365. Epub 2021 Jan 29.

Centre for Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

Objective: This study aimed to evaluate the epidemiological and clinicopathological spectrum of ocular malignancies among patients presenting to a teaching hospital in Northern India.

Methods: A total of 246 histopathologically diagnosed patients with ocular malignancies were included in the study. Tumor type and size, primary origin and location of tumor, clinical staging, radiological findings, histopathological type, and treatment outcomes were assessed. Read More

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January 2021

Epithelial-Myoepithelial Carcinoma.

Surg Pathol Clin 2021 Mar 6;14(1):97-109. Epub 2021 Jan 6.

Department of Anatomic Pathology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan. Electronic address:

Epithelial-myoepithelial carcinoma is an uncommon low-grade salivary gland carcinoma. It is classically characterized by biphasic tubular structures composed of inner eosinophilic ductal cells and outer clear myoepithelial cells. In addition, epithelial-myoepithelial carcinoma sometimes shows various histologic features, including a cribriform pattern, basaloid appearance, and sebaceous differentiation. Read More

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A case of Muir-Torre syndrome with a keratoacanthoma and sebaceous neoplasms: Clinicopathological features and a speculation on the pathogenesis of cutaneous tumor type.

J Dermatol 2021 May 1;48(5):690-694. Epub 2021 Feb 1.

Department of Dermatology, Hyogo Cancer Center, Akashi, Japan.

Muir-Torre syndrome is a hereditary condition characterized by occurrence of sebaceous neoplasms or keratoacanthomas and visceral tumors. The most common mechanism for this syndrome is a constitutional defect in the mismatch repair genes. We report the case of a 67-year-old woman with a mutator L homologue 1 (MLH1) mutation. Read More

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Metastatic Adenocarcinoma of the Lung Presenting as a Soft Tissue Mass.

Case Rep Surg 2021 6;2021:8856503. Epub 2021 Jan 6.

Department of Surgery, Western Reserve Health Education, Warren, Ohio, USA.

Lung cancer is the leading cause of cancer death in the United States, with more than 230,000 new cases, and approximately 150,000 deaths estimated for 2018. Lung cancer most commonly metastasizes to the brain, liver, lungs, bone, and adrenal system; however, there have been several cases of spread to soft tissues, with an incidence rate of approximately 0.75-9%. Read More

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January 2021

Clinicopathological analysis of 5146 eyelid tumours and tumour-like lesions in an eye centre in South China, 2000-2018: a retrospective cohort study.

BMJ Open 2021 01 26;11(1):e041854. Epub 2021 Jan 26.

Department of Ophthalmology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, China

Objectives: To describe the clinicopathological characteristics of patients with eyelid tumours and tumour-like lesions in South China, investigate possible factors affecting tumour constitution.

Design: Retrospective cohort study.

Setting: All patients diagnosed with eyelid tumours were included from a high-volume tertiary eye care centre from South China which caring for over 2000 patients per day. Read More

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January 2021

An updated review of the sebaceous gland and its role in health and diseases Part 1: Embryology, evolution, structure, and function of sebaceous glands.

Dermatol Ther 2021 01 1;34(1):e14695. Epub 2021 Jan 1.

Veterans Affairs Hospital and SUNY Downstate Dermatology Service, Brooklyn, New York, USA.

Sebaceous glands are sebum-secreting components of pilosebaceous units. The embryological development of the sebaceous gland follows that of the hair follicle and epidermal tissue, beginning between weeks 13 and 16 of fetal development. New sebaceous glands do not normally develop following birth, but their size increases with age. Read More

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January 2021

The COVID-19 facemask: Friend or foe?

J Plast Reconstr Aesthet Surg 2021 05 15;74(5):1101-1160. Epub 2020 Dec 15.

Division of Plastic Surgery, St. Luke's Hospital, Sacred Heart Campus, Allentown, Pennsylvania USA. Electronic address:

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Sebaceous Carcinoma of the Eyelid: A Systematic Review and Meta-Analysis.

Dermatol Surg 2021 01;47(1):104-110

Department of Otolaryngology, Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.

Background: Sebaceous carcinoma (SC) of the eyelid is a rare, aggressive malignancy associated with high rates of recurrence, metastasis, and tumor-related mortality.

Objective: Provide a collective analysis of clinical presentations, management techniques, and outcomes, and compare outcomes of common treatment methods.

Methods And Materials: Observational studies reporting management and outcomes of SC of the eyelid were included. Read More

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January 2021

Pagetoid tumour spread in periocular sebaceous gland carcinoma: a comparative analysis in 130 patients.

Eye (Lond) 2020 Dec 15. Epub 2020 Dec 15.

Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To compare the clinical features, histopathology features, treatment, and prognosis of patients with and without pagetoid tumour spread secondary to periocular sebaceous gland carcinoma (SGC).

Methods: Retrospective study of 130 patients with SGC who underwent conjunctival map biopsy.

Results: Of the 130 patients with SGC, 30 (23%) patients had histopathology proven pagetoid tumour spread. Read More

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December 2020

In cis TP53 and RAD51C pathogenic variants may predispose to sebaceous gland carcinomas.

Eur J Hum Genet 2021 Mar 15;29(3):489-494. Epub 2020 Dec 15.

Institute of Human Genetics, University of Leipzig Medical Center, 04103, Leipzig, Germany.

Pathogenic variants in TP53 have been classically thought to cause Li-Fraumeni syndrome (LFS), a cancer predisposition with high risks for various childhood- and adult-onset malignancies. However, increased genetic testing has lately revealed, that pathogenic variant carriers exhibit a broader range of phenotypes and that penetrance may be dependent both on variant type and modifiers. Using next generation sequencing and short tandem repeat analysis, we identified germline pathogenic variants in TP53 and RAD51C located in cis on chromosome 17 in a 43-year-old male, who has developed a rare sebaceous gland carcinoma (SGC) but so far no tumors of the LFS spectrum. Read More

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Sebaceous Epithelial-Myoepithelial Carcinoma With Aggressive Behavior and Evidence of Preexisting Pleomorphic Adenoma.

Int J Surg Pathol 2020 Dec 15:1066896920980804. Epub 2020 Dec 15.

University of Montreal, Montreal, Quebec, Canada.

Epithelial-myoepithelial carcinoma (EMCA) is a rare low-grade carcinoma of the salivary glands with multiple morphological variants. One such variant, sebaceous EMCA (SEMCA), has been reported in the literature. Distinguishing it from other tumors such as sebaceous carcinoma is crucial, as SEMCA typically behaves more indolently. Read More

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December 2020

Unsuccessful palliative treatment of extraocular sebaceous carcinoma with shave removal and electrocoagulation.

Dermatol Ther 2021 01 16;34(1):e14645. Epub 2020 Dec 16.

Department of Dermatology, Hospital Universitari Sagrat Cor, Grupo Quirónsalud, Barcelona, Spain.

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January 2021

Metachronous cutaneous squamous cell carcinoma in a young patient as the only presenting symptom to uncover Lynch syndrome with MLH1 Germline mutation.

Hered Cancer Clin Pract 2020 Nov 16;18(1):23. Epub 2020 Nov 16.

Department of Medicine, Division of Medical Oncology, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA.

Background: Cutaneous malignancies are rare complications of Lynch syndrome and can include Muir-Torre and Turcot syndromes that are associated with sebaceous gland tumors and keratoacanthomas. The incidence and clinical course of cutaneous squamous cell carcinoma have not been well documented in Lynch syndrome due to its rarity.

Case Presentation: A 49-year male presented with an enlarging groin skin lesion that was biopsed and demonstrated cutaneous squamous cell carcinoma for which he underwent a surgical resection. Read More

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November 2020

Case for diagnosis. Verrucous plaque on the pubic region.

An Bras Dermatol 2021 Jan-Feb;96(1):103-105. Epub 2020 Nov 20.

Department of Dermatology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil.

Muir-Torre syndrome is a rare, autosomal dominant genodermatosis, characterized by sebaceous neoplasms and visceral carcinomas. The authors describe the case of a patient who, 16 years after the diagnosis of colon carcinoma, presented a verrucous plaque on the pubic region, histopathologically compatible with sebaceous adenoma. The need to investigate this syndrome is emphasized, especially in cases of sebaceous neoplasms located outside the head, face, and neck. Read More

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February 2021