2,084 results match your criteria Sebaceous Carcinoma


Sebaceous Carcinoma of Upper Eyelid Presenting as Submandibular Lymphadenopathy.

J Cytol 2019 Jan-Mar;36(1):73-74

Department of Pathology, KEM Hospital, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/0970-9371.250131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343392PMC
February 2019

Bowen Disease with Invasive Mucin-Secreting Sweat Gland Differentiation: Report of a Case and Review of the Literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Central Zone (Halifax), NS,, Canada.

Bowen Disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. Read More

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http://dx.doi.org/10.1111/cup.13437DOI Listing
February 2019
1 Read

Peritumoral clefting as a key feature in differentiating basal cell carcinoma from trichoblastoma through in-vivo reflectance confocal microscopy.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Italy.

Adnexal tumors represent one of the most troublesome differential diagnosis when dealing with skin lesions with clinical and dermoscopic criteria suggestive for basal cell carcinoma (BCC). Among these, benign follicular tumors, and in particular trichoblastoma and trichoepithelioma, deserve a special mention as BCC mimickers. These are benign tumors showing differentiation toward the outer follicular sheath. Read More

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http://dx.doi.org/10.1111/jdv.15467DOI Listing
February 2019
6 Reads

[Histopathological study of basaloid follicular hamartoma].

Ann Dermatol Venereol 2019 Jan 25. Epub 2019 Jan 25.

Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.

Introduction: Basaloid follicular hamartoma (BFH) is a rare tumor first described in 1985. It bears clinical and histologic similarities with basal cell carcinoma (BCC), in particular the so-called infundibulocystic form. We performed a single-center clinicopathological study of a series of typical cases of this entity that is occasionally difficult to diagnose. Read More

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http://dx.doi.org/10.1016/j.annder.2018.12.007DOI Listing
January 2019
1 Read

Ectopic breast carcinoma presenting as sebaceous cyst left axilla.

BMJ Case Rep 2019 Jan 24;12(1). Epub 2019 Jan 24.

Department of Histopathology, Wythenshawe Hospital, Manchester, UK.

A 43-year-old woman with a positive family history of breast cancer presented with a painless lump in her left axilla for 2 years. Clinical diagnosis was a left axillary sebaceous cyst as the lump was inseparable from the skin. The lesion was excised under local anaesthesia and reported as breast tissue widely infiltrated by an invasive ductal carcinoma (grade 2). Read More

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http://dx.doi.org/10.1136/bcr-2018-224789DOI Listing
January 2019
1 Read

Multiple benign adnexal tumours: Anything but benign.

Australas J Dermatol 2019 Jan 22. Epub 2019 Jan 22.

St Vincent's Hospital, Sydney, New South Wales, Australia.

Muir Torre syndrome is an autosomal dominant disorder characterised by germline mutations in mismatch repair genes involved in DNA repair, leading to microsatellite instability and a propensity to tumour formation. We report a case of a 67-year-old gentleman who underwent biopsy of a smooth nodular lesion on the nasal tip, histopathologically consistent with sebaceous adenoma. Immunohistochemistry suggested a loss of MSH6. Read More

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http://doi.wiley.com/10.1111/ajd.12989
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http://dx.doi.org/10.1111/ajd.12989DOI Listing
January 2019
6 Reads

Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors.

J Dermatol 2019 Jan 21. Epub 2019 Jan 21.

Institute for Hematopathology, Hamburg, Germany.

The histogenesis of extraocular sebaceous carcinomas is - in contrast to ocular sebaceous carcinomas - unclear, and information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce. This study attempts to elucidate the histogenesis of sebaceous tumors, using multicolor immunofluorescence stainings to analyze 21 cases of sebaceous tumors (six each of extraocular sebaceous carcinoma, sebaceous adenoma and sebaceoma, and three cases of steatocystomas) and eight cases of normal sebaceous glands for p63, several keratins, androgen receptor, adipophilin, epithelial membrane antigen (EMA) and Ki-67. The data of this observational study provide evidence for the existence of two subpopulations of progenitors in normal sebaceous glands: (i) p63 K5 progenitors which generate the K10 luminal cells of sebaceous ducts; and (ii) p63 K5 K7 progenitors which finally generate K7 adipophilin EMA sebocytes. Read More

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http://dx.doi.org/10.1111/1346-8138.14765DOI Listing
January 2019
2 Reads

Cytokeratin expression in epidermal stem cells in skin adnexal tumors.

Oncol Lett 2019 Jan 8;17(1):927-932. Epub 2018 Nov 8.

Department of Pathology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China.

The expression levels of seven types of cytokeratin (CK) in different kinds of skin adnexal tumors were evaluated. One hundred and thirty-two patients with different kinds of skin adnexal tumors admitted and treated in the Department of Dermatology of Dongying People's Hospital from May 2013 to May 2015 were selected and underwent tissue section staining. Another 20 cases of normal skin were enrolled as the control group. Read More

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http://dx.doi.org/10.3892/ol.2018.9679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312935PMC
January 2019
1 Read

Mohs micrographic surgery for eyelid sebaceous carcinoma: a multicenter cohort of 360 patients.

J Am Acad Dermatol 2019 Jan 9. Epub 2019 Jan 9.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. Electronic address:

Background: The decision to perform Mohs micrographic surgery (MMS) or wide local excision (WLE) for eyelid sebaceous carcinoma (SC) is controversial.

Objective: To compare local recurrence, metastasis, and tumor-related mortality of patients with eyelid SC who were initially treated with MMS versus WLE.

Methods: A multicenter cohort study. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.053DOI Listing
January 2019

Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature.

World J Clin Cases 2018 Dec;6(16):1194-1198

Departments of Radiation Oncology, Dankook University Hospital, Dankook University College of Medicine, Cheonan 31116, South Korea.

Background: Primary sebaceous carcinoma of lacrimal gland (SCLG) is extremely rare. Due to its clinical characteristics, it is often misdiagnosed. It is known to be aggressive so delay in diagnosis can increase the chance of local recurrence and metastasis. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i16.1194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306633PMC
December 2018

Frequent TLE1 Expression in Cutaneous Neoplasms.

Am J Dermatopathol 2019 Jan;41(1):1-6

Dermatopathologist, Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

TLE1 immunohistochemistry is widely used as a biomarker for synovial sarcoma. Recently, we identified TLE1 expression in a subset of melanomas and noted staining in sebaceous glands and follicular epithelium. TLE1 immunohistochemistry has not been well studied in cutaneous tumors. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001186DOI Listing
January 2019
2 Reads

A squamous cell carcinoma in a young woman with Lynch syndrome.

Fam Cancer 2018 Dec 17. Epub 2018 Dec 17.

Department of Dermatology, Academic Medical Centre, Amsterdam, The Netherlands.

Lynch syndrome (LS) is an autosomal-dominant inherited disorder characterized by a predisposition to colorectal cancer and extracolonic cancers (particularly endometrium, ovary, stomach, small bowel, hepatobiliary tract, pancreas, urothelial tract, brain, and skin). Muir-Torre syndrome (MTS) is considered a phenotypical variant of LS, where patients develop sebaceous neoplasms and keratoacanthomas. Currently, only few studies and case reports suggest an association between LS and other skin cancers, such as Bowens' disease, melanoma and squamous cell carcinoma (SCC). Read More

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http://dx.doi.org/10.1007/s10689-018-00113-5DOI Listing
December 2018
2 Reads

Periocular Sebaceous Carcinoma With Apocrine Differentiation: A Case Report and Review of the Literature.

Int J Surg Pathol 2018 Dec 6:1066896918816806. Epub 2018 Dec 6.

1 Centro Hospitalar São João, Porto, Portugal.

A 61-year-old man presented with a dome-shaped tumor in the right eyelid. Histology revealed a cutaneous neoplasm with lobular growth pattern. It was composed of large basaloid cells, cells with sebaceous differentiation, and glandular structures with apocrine features. Read More

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http://dx.doi.org/10.1177/1066896918816806DOI Listing
December 2018
1 Read

Thymic epithelial neoplasms with sebaceous differentiation: a clinicopathological and Immunohistochemical study of 8 cases.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, The university of Texas, M D Anderson Cancer Center, Houston, TX. Electronic address:

Eight cases of primary thymic epithelial neoplasms corresponding to seven thymomas and one thymic carcinoma with sebaceous differentiation are presented. The patients are five men and three women between the ages of 45 and 63years (average: 54years) who presented with non-specific symptomatology related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.030DOI Listing
December 2018
7 Reads

Malignant eyelid tumors: Are intra-operative rapid frozen section and permanent section diagnoses of surgical margins concordant?

Int Ophthalmol 2018 Dec 8. Epub 2018 Dec 8.

Ophthalmic Pathology Laboratory (DKM), L V Prasad Eye Institute, Hyderabad, India.

Purpose: To study the concordance between intra-operative rapid frozen section and permanent section diagnoses of surgical margins following wide surgical excisional biopsy of malignant eyelid tumors.

Methods: This is a retrospective study of 120 cases and 429 frozen section slides.

Results: Of 120 cases, 75 (63%) had sebaceous gland carcinoma, 34 (28%) had basal cell carcinoma, and 11 (9%) had squamous cell carcinoma. Read More

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http://dx.doi.org/10.1007/s10792-018-1058-0DOI Listing
December 2018
2 Reads

Immunoreactivity for Sox10 in Basaloid Neoplasms of The Skin.

Appl Immunohistochem Mol Morphol 2019 Feb;27(2):114-118

Section of Dermatopathology, Division of Surgical Pathology-Cytopathology, University of Virginia Medical Center, Charlottesville, VA.

Basaloid tumors of the skin pose a diagnostic challenge to pathologists, because the differential diagnosis is broad, sometimes with subtle differentiating features. We evaluated SOX10 expression in 120 primary cutaneous tumors with epidermal, sweat glandular, neuroendocrine/neuroectodermal, follicular, and sebaceous lineages. Our findings were compared with those of previous studies that evaluated SOX10 in tumors of the skin. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000721DOI Listing
February 2019
2 Reads

Identification and regulation pattern analysis of long noncoding RNAs in meibomian gland carcinoma.

Epigenomics 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China.

Aim: To identify long noncoding RNAs (lncRNAs) and to elucidate regulation patterns of lncRNAs in meibomian gland carcinoma (MGC).

Materials & Methods: We used RNA-Seq, gene ontology, ClueGO, Ingenuity Pathway Analysis and co-expression network analyses to profile the expression and regulation patterns of lncRNAs and mRNAs in MGC.

Results: We identified 500 lncRNAs and 326 mRNAs as differentially expressed. Read More

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http://dx.doi.org/10.2217/epi-2018-0182DOI Listing
December 2018
3 Reads

Clinico-pathological predictors of mismatch repair deficiency in sebaceous neoplasia: A large case series from a single Australian private pathology service.

Australas J Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Clinical Pathology, Colorectal Oncogenomics Group, The University of Melbourne, Parkville, Victoria, Australia.

Background/objectives: Loss of expression of mismatch repair (MMR) proteins is frequently observed in sebaceous skin lesions and can be a herald for Lynch syndrome. The aim of this study was to identify clinico-pathological predictors of MMR deficiency in sebaceous neoplasia that could aid dermatologists and pathologists in determining which sebaceous lesions should undergo MMR immunohistochemistry (IHC).

Methods: An audit of sebaceous skin lesions (excluding hyperplasia) where pathologist-initiated MMR IHC was performed between January 2009 to December 2016 was undertaken from a single pathology practice identifying 928 lesions from 882 individuals. Read More

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http://doi.wiley.com/10.1111/ajd.12958
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http://dx.doi.org/10.1111/ajd.12958DOI Listing
December 2018
12 Reads

Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma.

Pathology 2019 Jan 28;51(1):67-73. Epub 2018 Nov 28.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Hong Kong. Electronic address:

Malignant transformation of benign mature ovarian teratoma can result in a wide spectrum of cancer, including a variety of carcinoma, sarcoma, or melanoma. The role of mismatch repair defects in such malignant transformation is still elusive. In view of current immunotherapy, the role of mismatch repair deficiency can have significant implications on therapeutic strategy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183034
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http://dx.doi.org/10.1016/j.pathol.2018.09.061DOI Listing
January 2019
10 Reads

Clinicopathological characteristics of breast sebaceous adenocarcinoma.

Pol J Pathol 2018 ;69(3):226-233

Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. Read More

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http://dx.doi.org/10.5114/pjp.2018.79542DOI Listing
January 2018
3 Reads

Les difficultés du diagnostic : du carcinome basocellulaire aux tumeurs trichoblastiques: From basal cell carcinoma to trichoblastic tumors: a diagnostic challenge.

Authors:
B Cribier

Ann Dermatol Venereol 2018 Nov;145 Suppl 5:VS3-VS11

Clinique dermatologique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address:

Basal cell carcinoma (BCC) is a very common tumor, of which the diagnosis is generally easy. Clinical prediction of histopathological subtype however is however often difficult, i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638183125
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http://dx.doi.org/10.1016/S0151-9638(18)31254-7DOI Listing
November 2018
14 Reads

A retrospective study of 2228 cases with eyelid tumors.

Int J Ophthalmol 2018 18;11(11):1835-1841. Epub 2018 Nov 18.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China.

Aim: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015.

Methods: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.11.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232338PMC
November 2018
9 Reads

Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations.

Clin Cancer Res 2018 Nov 12. Epub 2018 Nov 12.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Ocular adnexal (OA) sebaceous carcinoma is an aggressive malignancy of the eyelid and ocular adnexa that frequently recurs and metastasizes, and effective therapies beyond surgical excision are lacking. There remains a critical need to define the molecular-genetic drivers of the disease to understand carcinomagenesis and progression and to devise novel treatment strategies. We present next-generation sequencing of a targeted panel of cancer-associated genes in 42 and whole transcriptome RNA sequencing from eight OA sebaceous carcinomas from 29 patients. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-1688DOI Listing
November 2018
9 Reads
8.722 Impact Factor

Lamellar rotation surgery: a new procedure for repairing upper eyelid defects.

Authors:
Qingji Li

BMC Ophthalmol 2018 Nov 7;18(1):291. Epub 2018 Nov 7.

Department of Oculoplastic and Reconstructive Surgery, Tianjin Aier Eye Hospital, No.102, Fukang Road, Nankai District, Tianjin, 300190, People's Republic of China.

Background: To report "Lamellar Rotation Surgery",a new technique for repairing large and moderate full-thickness upper eyelid defects.

Methods: A two-stage technique is described in which a vertical incision is made in the tarsus of the lower eyelid with elevation of the lateral posterior lamella while sparing the lower eyelid orbicularis and skin to be rotated superiorly to form the reconstructed posterior lamella of the upper eyelid. Additionally, a lateral periosteal flap is used to reconstruct the lateral canthal tendon, and a McGregor procedure is used to reconstruct the anterior lamella of the upper eyelid. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0958-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222999PMC
November 2018
8 Reads

Dermatological conditions seen in renal transplant recipients in a Singapore tertiary hospital.

Singapore Med J 2018 Oct;59(10):519-523

Department of Dermatology, Singapore General Hospital, Singapore.

Introduction: Lifelong immunosuppression after renal transplant exerts effects on the recipients' skin, including skin infections, skin cancers and drug-induced skin disorders. Our study aimed to determine the epidemiology of skin conditions among renal transplant recipients in the largest tertiary hospital in Singapore.

Methods: We reviewed the medical records of kidney transplant recipients at Singapore General Hospital, Singapore, between 1 January 2003 and 31 December 2013. Read More

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http://dx.doi.org/10.11622/smedj.2018126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199188PMC
October 2018
10 Reads

Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid - a population-based analysis.

Orbit 2018 Oct 29:1-8. Epub 2018 Oct 29.

a Department of Ophthalmology , Oakland University William Beaumont School of Medicine , Royal Oak , MI , USA.

Purpose: To evaluate prognostic factors and survival of patients with sebaceous carcinoma of the eyelid through a population-based analysis.

Methods: A total of 940 patients with primary sebaceous carcinoma of the eyelid were derived from the Surveillance, Epidemiology, and End Results (SEER) database in the United States from 1973 to 2013. Kaplan-Meier univariate analysis and Cox Regression multivariate analysis were performed to examine prognostic factors in overall survival (OS). Read More

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http://dx.doi.org/10.1080/01676830.2018.1505922DOI Listing
October 2018
1 Read

Merkel cells in extraocular sebaceous carcinoma.

J Cutan Pathol 2019 Mar 27;46(3):171-174. Epub 2018 Nov 27.

Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, California.

Introduction: Mature sebaceous glands do not contain Merkel cells. Neither do sebaceous tumors in the vast majority of cases. Recently, however, it was showed that rare sebaceous adenomas with a carcinoid-like or labyrinthine pattern can contain intratumoral Merkel cells. Read More

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http://doi.wiley.com/10.1111/cup.13381
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http://dx.doi.org/10.1111/cup.13381DOI Listing
March 2019
4 Reads

Malignant Transformation of Mature Cystic Teratoma: Is Squamous Cell Carcinoma Different From the Other Types of Neoplasm?

Int J Gynecol Cancer 2018 Nov;28(9):1650-1656

Department of Obstetrics and Gynecology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.

Objectives: Malignant transformation of mature cystic teratoma (MCT) is rare. Unlike squamous cell carcinoma (SCC) in MCT, the other types of neoplasm in MCT have not been discussed in publications. We analyzed the clinical characteristics and prognosis of the other types of neoplasm (non-SCC) compared with those of SCC. Read More

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http://dx.doi.org/10.1097/IGC.0000000000001375DOI Listing
November 2018
9 Reads

An Ulcerated Reddish Nodule of the Chest: When You See, Think ….

Dermatopathology (Basel) 2018 Jul-Sep;5(3):117-120. Epub 2018 Sep 19.

Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

A 97-year-old man with a previous personal history of multiple nonmelanoma skin cancers presented with a fast-growing, ulcerated reddish nodule on his chest. The nodule was surgically removed, and hematoxylin and eosin stains of the specimen showed an asymmetrical, nonpigmented lesion with architectural and structural impairment, round cells with clear, whitish, foamy cytoplasm, multiple dermal mitoses and nuclear pleomorphism. Our first hypothesis was sebaceous carcinoma, a rare malignant neoplasm derived from epithelial cells showing sebaceous differentiation. Read More

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https://www.karger.com/Article/FullText/491923
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http://dx.doi.org/10.1159/000491923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180268PMC
September 2018
13 Reads

Super-Thick Amniotic Membrane Graft for Ocular Surface Reconstruction.

Am J Ophthalmol 2019 Feb 9;198:45-53. Epub 2018 Oct 9.

The New York Eye Cancer Center, New York, New York, USA.

Purpose: The purpose of this study was to evaluate super-thick amniotic membrane grafts (ST-AMGs) for ocular surface reconstruction.

Design: Retrospective, interventional case series.

Methods: This was a single-center study of clinical practice that included select patients with typically large ocular surface abnormalities that required reconstruction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183057
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http://dx.doi.org/10.1016/j.ajo.2018.09.035DOI Listing
February 2019
4 Reads

A Case Report of Recurrent Metastatic Sebaceous Carcinoma Which Showed Favorable Response Tt Non-Fluorouracil Based Chemotherapy.

Am J Case Rep 2018 Oct 6;19:1192-1196. Epub 2018 Oct 6.

Division of Hematology-Oncology, Department of Internal Medicine, Daejeon Sun Medical Center,, Daejeon, South Korea.

BACKGROUND Sebaceous carcinoma is a rare malignant tumor of the skin adnexa. While surgical resection is a treatment of choice in localized disease, frequent recurrence and distant metastasis make treatment difficult. Moreover, due to its rarity, optimal systemic treatment has not been determined. Read More

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http://dx.doi.org/10.12659/AJCR.912552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187987PMC
October 2018
3 Reads

Contemporary update of overall prognosis and nomogram to predict individualized survival for Chinese patients with eyelid sebaceous carcinoma.

EBioMedicine 2018 Oct 17;36:221-228. Epub 2018 Sep 17.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China.. Electronic address:

Background: The prognosis of Chinese patients with eyelid sebaceous carcinoma (SC) has not been updated for >3 decades. The prognostic predictors are multifactorial, and there is no validated prognostic model for eyelid SC.

Methods: This study included 238 consecutive patients with eyelid SC. Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197575PMC
October 2018
2 Reads

High expression of PD-1 and PD-L1 in ocular adnexal sebaceous carcinoma.

Oncoimmunology 2018 26;7(9):e1475874. Epub 2018 Jul 26.

Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Ocular adnexal sebaceous carcinoma (OASC) is an aggressive malignancy that frequently recurs locally and metastasizes. Surgical extirpation may produce significant aesthetic morbidity, and effective systemic therapies for locally advanced or metastatic disease are largely ineffective. Immune checkpoint inhibitors have shown efficacy in the management of several solid tumors where tumor cell PD-L1 expression correlates with improved response. Read More

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http://dx.doi.org/10.1080/2162402X.2018.1475874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140585PMC
July 2018
4 Reads

Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation.

Gynecol Oncol Rep 2018 Nov 29;26:37-40. Epub 2018 Aug 29.

Department of Pathology, Cedars-Sinai Medical Center, United States.

Sebaceous carcinomas are rare tumors, with the majority of described cases occurring within the eyelid. To date, there are nine documented reports of sebaceous carcinoma arising within a mature cystic teratoma of the ovary. Although the majority of cases originate from idiopathic mutations, there exists a strong association between this rare tumor and hereditary syndromes of DNA mismatch repair deficiency, such as Lynch syndrome and the lesser-known Muir-Torre syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23525789183008
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http://dx.doi.org/10.1016/j.gore.2018.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138851PMC
November 2018
8 Reads

Clinical and ophthalmological outcome of endoscopic transorbital surgery for cranioorbital tumors.

J Neurosurg 2018 Sep 1:1-9. Epub 2018 Sep 1.

4Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine; and.

OBJECTIVECranioorbital tumors are complex lesions that involve the deep orbit, floor of the frontal bone, and lesser and greater wing of the sphenoid bone. The purpose of this study was to describe the clinical and ophthalmological outcomes with an endoscopic transorbital approach (TOA) in the management of cranioorbital tumors involving the deep orbit and intracranial compartment.METHODSThe authors performed endoscopic TOAs via the superior eyelid crease incision in 18 patients (16 TOA alone and 2 TOA combined with a simultaneous endonasal endoscopic resection) with cranioorbital tumors from September 2016 to November 2017. Read More

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http://dx.doi.org/10.3171/2018.3.JNS173233DOI Listing
September 2018
10 Reads

The Usefulness of Dermoscopy in Extraocular Sebaceous Carcinoma.

Indian J Dermatol 2018 Sep-Oct;63(5):440-442

Department of Dermatology and Venereology, Pramukshwami Medical College, Karamsad, Gujarat, India. E-mail:

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http://www.e-ijd.org/text.asp?2018/63/5/440/240101
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http://dx.doi.org/10.4103/ijd.IJD_315_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124233PMC
September 2018
14 Reads

Dermoscopy of Adnexal Tumors.

Dermatol Clin 2018 Oct 16;36(4):397-412. Epub 2018 Aug 16.

Dermatology Department, Hospital General Universitario de Alicante, ISABIAL, C/Maestro Alonso 109, 03010 Alicante, Spain.

Cutaneous adnexal tumors include lesions with apocrine, eccrine, follicular, sebaceous, and mixed differentiation. Most are benign and sporadic, although malignant forms are occasionally observed and some cases develop in the setting of inherited syndromes. These tumors often cause immense diagnostic difficulty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183107
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http://dx.doi.org/10.1016/j.det.2018.05.007DOI Listing
October 2018
13 Reads

Expression of hormone receptors, adipophilin, and GCDFP-15 in mucinous carcinoma of the skin.

J Cutan Pathol 2018 Dec 4;45(12):886-890. Epub 2018 Oct 4.

Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Background: Primary cutaneous mucinous carcinoma (PCMC) is a rare epithelial tumor with unclear histogenesis.

Methods: We evaluated the immunohistochemical expression of the estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR) in six cases of PCMC. The immunoreactivity of adipophilin and gross cystic disease fluid protein (GCDFP)-15 was investigated to determine the origin of the tumor. Read More

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http://dx.doi.org/10.1111/cup.13349DOI Listing
December 2018
1 Read

Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients.

Br J Ophthalmol 2018 Aug 21. Epub 2018 Aug 21.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Background/aims: To validate the predictive value of the American Joint Committee on Cancer (AJCC) 8th-edition classification for local recurrence, metastasis and survival in patients with eyelid sebaceous carcinoma.

Methods: We performed a retrospective review of 100 consecutive patients with eyelid sebaceous carcinoma. Eyelid carcinomas were staged according to the AJCC 7th-edition and 8th-edition criteria. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312635DOI Listing
August 2018
2 Reads

Comparison of posterior lamellar resection versus lumpectomy for initial management of localized tarsal conjunctival sebaceous carcinoma in 54 cases.

Indian J Ophthalmol 2018 09;66(9):1295-1300

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose: Comparison of outcomes of localized eyelid sebaceous carcinoma (American Joint Committee on Cancer (AJCC) 8 edition categories T1, T2, T3) following initial management with posterior lamellar resection (PLR) versus (vs) lumpectomy (nonposterior lamellar resection, non-PLR).

Methods: This was a retrospective, comparative, interventional case series. Of 54 patients, 26 were managed by PLR and 28 by nonPLR. Read More

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http://dx.doi.org/10.4103/ijo.IJO_239_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113834PMC
September 2018
4 Reads

Sebaceous gland carcinoma: Can we do better?

Indian J Ophthalmol 2018 09;66(9):1235-1237

Editor, Indian Journal of Ophthalmology, Editorial Office: Centre for Sight, Road No 2, Banjara Hills, Hyderabad - 500 034, Telangana, India.

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http://dx.doi.org/10.4103/ijo.IJO_1370_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113820PMC
September 2018
1 Read

Intraoral Sebaceous Carcinoma: Case Report of a Rare Tumor Emphasizing the Histopathological Differential Diagnosis.

Case Rep Dent 2018 9;2018:3054931. Epub 2018 Jul 9.

Department of Oral and Maxillofacial Surgery, Guru Nanak Dev Dental College, Sunam, Punjab, India.

Background: Sebaceous carcinoma (SC) is an uncommon cutaneous malignancy, usually occurring predominantly in the eyelids and only occasionally involving the oral cavity. Sebaceous carcinoma (SC) is a rare malignancy. Only 10 cases of sebaceous carcinoma of the oral cavity have been reported so far. Read More

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http://dx.doi.org/10.1155/2018/3054931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079601PMC

Sebaceous Carcinoma in Situ Masquerading Clinically and Histologically as Paget Disease of the Breast.

S D Med 2018 Aug;71(8):350-353

Department of Pathology, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Sebaceous carcinoma in situ is a poorly understood and ill-defined entity. In situ sebaceous carcinoma exhibits a similar location pattern to its invasive counterpart in that most commonly has a periorbital distribution. Review of the literature found only seven cases of extraocular sebaceous carcinoma in situ. Read More

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August 2018
3 Reads

INSM1 Is More Sensitive and Interpretable than Conventional Immunohistochemical Stains Used to Diagnose Merkel Cell Carcinoma.

Am J Surg Pathol 2018 Nov;42(11):1541-1548

Department of Pathology and Laboratory Medicine, Division of Dermatopathology, Dartmouth-Hitchcock Medical Center, Lebanon.

Merkel cell carcinoma (MCC) is an extremely aggressive skin cancer that must be distinguished from other basaloid cutaneous neoplasms that have different treatments and prognoses. This is sometimes challenging in small shave specimens, crushed samples, lymph nodes, and core needle biopsies. Insulinoma-associated protein 1 (INSM1) immunohistochemistry is a sensitive nuclear marker of neuroendocrine differentiation. Read More

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http://Insights.ovid.com/crossref?an=00000478-201811000-0001
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http://dx.doi.org/10.1097/PAS.0000000000001136DOI Listing
November 2018
13 Reads

Hierarchical Cluster Analysis of Cytokeratins and Stem Cell Expression Profiles of Canine Cutaneous Epithelial Tumors.

Vet Pathol 2018 11 2;55(6):821-837. Epub 2018 Aug 2.

1 Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan.

The diagnosis of cutaneous epithelial tumors (CETs) in dogs is based on predominant histological differentiation patterns. However, the expression of a broad panel of antigens has not been comprehensively examined with immunohistochemistry. The present study aims to establish a comprehensive expression profile and identify useful diagnostic markers for each CET type. Read More

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http://dx.doi.org/10.1177/0300985818785680DOI Listing
November 2018
13 Reads

Basal Cell Carcinoma with Sebaceous Differentiation.

Indian Dermatol Online J 2018 Jul-Aug;9(4):273-275

Department of Dermatology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_219_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042192PMC
July 2018
1 Read

Clinicopathological features of considerable reduction in androgen receptor expression in sebaceous gland carcinoma of the eyelid.

Int Ophthalmol 2018 Jul 19. Epub 2018 Jul 19.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630, Sugitani, Toyama, 930-0194, Japan.

Purpose: This study aimed to evaluate the relationships between androgen receptor (AR) expression and clinicopathologic features of sebaceous gland carcinoma (SGC) of the eyelid.

Methods: AR expression was evaluated via immunohistochemistry analysis of surgically derived samples from 11 patients with SGC of the eyelid.

Results: The expression of AR was evident in 9 of 11 patients (82%). Read More

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http://dx.doi.org/10.1007/s10792-018-0990-3DOI Listing
July 2018
2 Reads

[Establishment of standardized diagnosis and treatment of eyelid sebaceous carcinoma in China].

Authors:
D M Li

Zhonghua Yan Ke Za Zhi 2018 Jul;54(7):481-483

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing 100730, China.

Eyelid sebaceous carcinoma is a malignant tumor originating from Meibomian glands, Zeis glands, and other glands surrounding hair follicles. It is the second most common eyelid malignancy, following basal cell carcinoma, in China. Considering its diversified clinical manifestations and strong tendency for recurrence and metastasis, standardized cancer staging, surgical excision with frozen section control, and postsurgical follow-up has been internationally adopted with the aim to considerably reduce the risk of recurrence and metastasis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.07.001DOI Listing
July 2018
10 Reads

Current review of sebaceous cell carcinoma.

Curr Opin Ophthalmol 2018 Sep;29(5):445-450

Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY.

Purpose Of Review: Periocular sebaceous cell carcinoma is a rare malignancy that is often misdiagnosed leading to increased morbidity and mortality. This review aims to describe current knowledge on the disease to aid clinicians in timely diagnosis and treatment.

Recent Findings: New research has shown that the diagnosis of sebaceous cell carcinoma can be aided with immunohistochemical stains. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000505DOI Listing
September 2018
5 Reads