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    1 OF 40

    Cumulative risk of skin tumours in patients with Lynch syndrome.
    Br J Dermatol 2018 Mar 15. Epub 2018 Mar 15.
    Department of Gastroenterology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
    Lynch syndrome (LS) is an autosomal-dominant disorder characterized by a predisposition to colorectal cancer and extracolonic malignancies. LS is caused by a germline mutation in one of the four DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6 and PMS2) or loss of expression of MSH2 due to deletion in the EPCAM gene. Muir-Torre syndrome (MTS) is considered a variant of LS, in which patients present with sebaceous neoplasms and/or keratoacanthomas. Read More

    Cutaneous horn: A mask to underlying malignancy.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S87-S90
    Department of Oral Pathology, Manubhai Patel Dental College, Vadodara, Gujarat, India.
    Cutaneous horns () are uncommon lesions consisting of keratotic material resembling that of an animal horn. It is a conical- or cylindrical-shaped excessive hyperkeratosis of variable size ranging from few millimeters to several centimeters with a variable in size and shape, such as cylindrical, conical, pointed, transversely or longitudinally corrugated, or curved like a ram's horn. The lesions typically occur in sun-exposed areas, particularly the face, ear, nose, forearms and dorsum of hands. Read More

    Keratinizing pleomorphic adenoma: An unusual case report.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S69-S72
    Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.
    Pleomorphic adenoma (PA) is the most common benign tumor of major or minor salivary glands. PA exhibits a great histological diversity, such as differentiation into oncocytic, sebaceous, mucinous, squamous, chondroid, osseous or adipose cells. Squamous metaplasia rarely results in the formation of extensive keratin-filled cyst lined by squamous epithelium. Read More

    Immunohistochemical evaluation of stress-responsive protein sestrin2 and its correlation with p53 mutational status in eyelid sebaceous gland carcinoma.
    Br J Ophthalmol 2018 Feb 24. Epub 2018 Feb 24.
    Department of Zoology, Sri Venkateswara College, University of Delhi, New Delhi, India.
    Background: p53 is a stress-activated tumour suppressor gene, and its mutation has been associated with solid tumours including non-melanoma skin cancers. Sestrin2 expression is associated with DNA damage and oxidative stress and has been described as a downstream target of p53 network. However, its role in sebaceous gland carcinoma (SGC) remains unexplored. Read More

    14-year case series of eyelid sebaceous gland carcinoma in Chinese patients and review of management.
    Br J Ophthalmol 2018 Feb 19. Epub 2018 Feb 19.
    Department of Ophthalmology, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, China.
    Aims: Sebaceous gland carcinoma (SGC) of the eyelid is a rare but potentially deadly cancer. The purpose of this study was to determine whether the American Joint Committee on Cancer (AJCC) 7th Edition T category for SGC correlated with metastasis and survival in the Chinese population.

    Methods: This was a retrospective, single-centre cohort study. Read More

    Homeobox transcriptional factor engrailed homeobox 1 is specifically expressed in normal and neoplastic sweat gland cells.
    Histopathology 2018 Feb 12. Epub 2018 Feb 12.
    Department of Human Pathology Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
    Aim: A number of homeobox transcriptional factors are utilized as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is specifically expressed in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms.

    Methods And Results: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be specifically expressed in the skin. Read More

    GATA3 staining in primary cutaneous apocrine cribriform carcinoma: Usefulness to differentiate it from breast cancer metastasis.
    J Cutan Pathol 2018 Feb 12. Epub 2018 Feb 12.
    Dermatopathology Department, Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
    Background: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raises a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer.

    Objective: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test its usefulness to differentiate this tumor from metastatic breast cancer.

    Methods: We retrieved 14 cases with PCACC (each from a different patient) from the files of the authors. Read More

    Analysis of hedgehog signaling in periocular sebaceous carcinoma.
    Graefes Arch Clin Exp Ophthalmol 2018 Apr 8;256(4):853-860. Epub 2018 Feb 8.
    Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts & London School of Medicine, 4 Newark St, London, E1 2AT, UK.
    Purpose: Sebaceous carcinoma (SC) is a clinical masquerader of benign conditions resulting in significant eye morbidity, sometimes leading to extensive surgical treatment including exenteration, and even mortality. Little is known about the genetic or molecular basis of SC. This study identifies the involvement of Hedgehog (Hh) signaling in periocular SC. Read More

    Cutaneous metastasis of a primary oesophageal adenocarcinoma to the right cheek.
    J Surg Case Rep 2017 Sep 18;2017(9):rjx181. Epub 2017 Sep 18.
    Department of Oral and Maxillofacial Surgery, Royal Albert Edward Infirmary, Wigan, England, UK.
    This case report details of a case of cutaneous metastasis from a primary adenocarcinoma of the oesophagus to the right cheek. A 67-year-old male was referred to the maxillofacial department with a 2-3 week history of non-painful swelling of the cheek. A diagnosis of infected sebaceous cyst was made and drainage was attempted with adjunctive antibiotic therapy. Read More

    Rare desmoplastic trichilemmoma associated with sebaceous nevus.
    An Bras Dermatol 2017 Nov-Dec;92(6):836-837
    Private Clinic - São Paulo (SP), Brazil.
    Nevus sebaceous of Jadassohn is a congenital hamartoma that usually affects the scalp and face. Several benign or malignant neoplasias may develop in the lesion and the most common are trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma. Trichilemmoma is a benign solid tumor originating from external sheath cells of pilosebaceous follicles. Read More

    Microcystic adnexal carcinoma with sebaceous differentiation: Three cases.
    J Cutan Pathol 2018 Apr 15;45(4):290-295. Epub 2018 Feb 15.
    Private Practice, Friedrischafen, Friedrichshafen Dermatopathologie, Friedrischafen, Germany.
    Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. Read More

    Chemical imaging of aggressive basal cell carcinoma using time-of-flight secondary ion mass spectrometry.
    Biointerphases 2018 Jan 12;13(3):03B402. Epub 2018 Jan 12.
    Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg 412 96, Sweden.
    A set of basal cell carcinoma samples, removed by Mohs micrographic surgery and pathologically identified as having an aggressive subtype, have been analyzed using time-of-flight secondary ion mass spectrometry (SIMS). The SIMS analysis employed a gas cluster ion beam (GCIB) to increase the sensitivity of the technique for the detection of intact lipid species. The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface. Read More

    The limitations of dermoscopy: false-positive and false-negative tumours.
    J Eur Acad Dermatol Venereol 2018 Jan 5. Epub 2018 Jan 5.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. Read More

    Case report repairing orbital skin defects using composite flaps after giant eyelid-derived tumor excision and orbital exenteration.
    Medicine (Baltimore) 2017 Dec;96(48):e8978
    Department of Ophthalmology, Second Hospital of JiLin University, ChangChun.
    Rationale: Though giant malignant tumors arising in the eyelid are rare, they often require extensive surgery for removal along with orbital exenteration. Because of this, repairing orbital defects is an important factor in the surgical strategy.

    Patient Concerns: Case 1 was a 78-year-old nomad man who presented in the Department of Ophthalmology with a giant tumor in his right eyelid, which had developed over three years. Read More

    Cutaneous Metaplastic Carcinoma: Report of a Case With Sebaceous Differentiation.
    Am J Dermatopathol 2017 Dec 28. Epub 2017 Dec 28.
    Department of Dermatology, Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP), São Paulo, Brazil.
    In this study, a case of a 56-year-old woman with cutaneous metaplastic carcinoma in the neck is reported. It harbored basal cell carcinoma, squamous cell carcinoma, and sebaceous carcinoma, as well as osteosarcoma (with fibroblastic, osteoblastic, aneurysmal bone cyst-like, and chondroblastic patterns). To our knowledge, the literature does not mention sebaceous carcinoma in cutaneous metaplastic carcinoma. Read More

    Intraoral Pigmented Low-Grade Adenocarcinoma, Not Otherwise Specified: Case Report and Immunohistochemical Study.
    Head Neck Pathol 2017 Dec 22. Epub 2017 Dec 22.
    Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Avenida do Café, S/N, Ribeirão Preto, São Paulo, 14040-904, Brazil.
    Salivary adenocarcinoma, not otherwise specified (AdCaNOS) is a rare malignant tumor with potential diagnostic challenge, which mainly affects the parotid glands; however, the minor salivary glands can also be involved by AdCaNOS. This paper reports a case of a 45-year-old Afro-descendant woman complaining of a slow-growing mass with 6 months of evolution in the left superior vestibular fornix. Microscopic examination revealed an infiltrative epithelial neoplasm composed of predominantly solid growth pattern, arranged in a lobular configuration, admixed with glandular or ductal structures. Read More

    Extraocular sebaceous carcinoma accompanied by invasive squamous cell carcinoma: The first case report and consideration of histogenesis.
    J Dermatol 2017 Dec 21. Epub 2017 Dec 21.
    Department of Dermatology, Kansai Medical University, Osaka, Japan.
    A 61-year-old man presented with a dome-shaped nodule, 1.2 cm in size, with a central crater covered by keratinous material near the left lateral malleolus. Histological findings demonstrated a basophilic circular cone in the center, surrounded and sharply demarcated by a broad eosinophilic area. Read More

    Dermoscopic features distinctive for extraocular sebaceous carcinoma.
    J Dermatol 2017 Dec 13. Epub 2017 Dec 13.
    Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
    We examined dermoscopic features of three cases of extraocular sebaceous carcinoma and reviewed the literatures. The yellowish structures, polymorphous vessels and ulceration were common findings in our cases and all cases of the previous reports. The appearance of whitish-pink areas has not been described previously. Read More

    Dermatological Complications After Solid Organ Transplantation.
    Clin Rev Allergy Immunol 2018 Feb;54(1):185-212
    Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
    Organ transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e. Read More

    Immunohistochemical expression of X-linked inhibitor of apoptosis in eyelid sebaceous gland carcinoma predicts a worse prognosis.
    Indian J Ophthalmol 2017 Nov;65(11):1109-1113
    Department of Ocular Pathology, Dr. R. P. Centre, AIIMS, New Delhi, India.
    Purpose: Overexpression of the inhibitors of apoptosis proteins have been demonstrated in a variety and of solid tumors including melanomas and nonmelanomas skin cancers. X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of apoptosis which prevents apoptosis by inhibiting caspases 9, 7, and 3. The prognostic value of XIAP in sebaceous gland carcinoma (SGC) remains unexplored. Read More

    Cutaneous metastasis of renal cell carcinoma masquerading as an infected sebaceous cyst.
    J Stomatol Oral Maxillofac Surg 2017 Nov 8. Epub 2017 Nov 8.
    Department of Urology, Christian Medical College, Vellore, India.
    Renal cell carcinoma (RCC) is the third most common genitourinary malignancy with an estimated one third of cases with metastatic disease at the time of diagnosis. Though rare, cutaneous metastasis from RCC is more frequent than any other genitourinary malignancy. Metastasis of RCC to skin carries poor prognosis as coexistent visceral spread is the norm. Read More

    Basal Cell Carcinoma of Vermilion Mucosa of Upper Lip: a Rare Case Report.
    Acta Med Indones 2017 Jul;49(3):255-258
    Department of Dermatology, Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Although basal cell carcinoma (BCC) is a common skin tumor, very rare cases of BCC arising from upper vermilion mucosa of lip have been reported previously. This tumor basically, originates from pillar structures and the involvement of the vermilion lip contrasts this concept so it is devoid of hair follicles and sweat glands. The exact pathogenesis of vermilion lip BCC is not clear but it has been postulated that the neoplasm originates from the pluripotential epithelial cells of the oral mucosa and epidermis. Read More

    Immunohistochemical markers informing the diagnosis of sebaceous carcinoma and its distinction from its mimics: Adipophilin and factor XIIIa to the rescue?
    J Cutan Pathol 2018 Jan;45(1):29-32
    Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Sebaceous carcinoma typically presents a diagnostic challenge because it mimics other more common, locally invasive carcinomas, including squamous cell carcinoma and basal cell carcinoma-particularly when one of these tumors exhibits concomitant clear-cell changes. Immunohistochemical studies offering high sensitivity and specificity are critical for accurate diagnosis. Read More

    Reticulated acanthoma with sebaceous differentiation mimicking melanoma.
    Dermatol Pract Concept 2017 Jul 31;7(3):35-37. Epub 2017 Jul 31.
    Department of Dermatology, Mogi das Cruzes University, Mogi das Cruzes, Brazil.
    Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. Read More

    Sebaceous lesions of the skin.
    Pathology 2017 Dec 25;49(7):688-697. Epub 2017 Oct 25.
    Dermatopathology Group, Department of Anatomical Pathology, PathWest, Perth, Australia; School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia. Electronic address:
    Sebaceous differentiation is commonly seen in cutaneous neoplasms, both in the context of lesions showing predominantly sebaceous differentiation (e.g., sebaceous adenoma, sebaceoma and sebaceous carcinoma), or as more focal sebaceous components in neoplasms with other primary lines of differentiation. Read More

    Histologic Mimics of Basal Cell Carcinoma.
    Arch Pathol Lab Med 2017 Nov;141(11):1490-1502
    From the Departments of Pathology (Drs Stanoszek, Wang, and Harms) and Dermatology (Dr Harms), University of Michigan Medical School, Ann Arbor. Drs Stanoszek and Wang contributed equally.
    Context: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Read More

    Microcystic adnexal carcinoma of the orbit mimicking pagetoid sebaceous gland carcinoma.
    Orbit 2017 Oct 20:1-3. Epub 2017 Oct 20.
    d Medical Director, MN Eye Hospital , Chennai , India.
    Microcystic adnexal carcinoma (MAC) is a rare malignancy of sweat glands that has been reported most often on the face in the form of a cutaneous lesion, with the potential for deeper invasion. The synonyms of MAC include sclerosing sweat duct carcinoma, syringomatous carcinoma, and malignant syringoma. Clinically, MAC in the periocular area has been misdiagnosed as basal cell carcinoma, squamous cell carcinoma, or even chalazia. Read More

    Sebaceous carcinoma in situ as a concept and diagnostic entity.
    Dermatol Pract Concept 2017 Jul 31;7(3):27-31. Epub 2017 Jul 31.
    Departments of Pathology and Dermatology, Hofstra Northwell School of Medicine, Hempstead, NY, USA.
    Although carcinoma in situ has been accepted as a well-established concept and diagnostic category, for reasons unknown sebaceous carcinoma in situ has not been recognized yet in general pathology or dermatopathology. Such lesions have always been misinterpreted as either benign neoplasm or sebaceous carcinoma. In the present essay, we provide a convincing account supporting sebaceous carcinoma in situ as a valid concept and diagnostic entity via critical literature review and histopathological assessment and illustration. Read More

    [Proliferation of a basal cell carcinoma on a sebaceous nevus of the lower eyelid: Case report of a rare association].
    J Fr Ophtalmol 2017 Nov 21;40(9):e367-e369. Epub 2017 Oct 21.
    Service d'ophtalmologie B de l'hôpital des spécialités, université Mohammed V Souissi, centre hospitalier universitaire, avenue des Nations Unies, Agdal, Rabat, Maroc.

    Disfiguring facial pyoderma vegetans with an excellent outcome.
    BMJ Case Rep 2017 Oct 13;2017. Epub 2017 Oct 13.
    Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
    We describe a case of disfiguring facial pyoderma vegetans in order to highlight the challenges in managing this rare skin condition and review the literature.A 54-year-old woman presented to dermatology clinic with a 3-month history of a left-sided facial lesion, which had been treated as an infected sebaceous cyst. The lesion had dramatically increased in size in the weeks prior to presentation. Read More

    A Case of Phacomatosis Pigmentokeratotica Associated With Multiple Basal Cell Carcinomas.
    Am J Dermatopathol 2018 Feb;40(2):131-135
    Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
    Phacomatosis pigmentokeratotica is a recently identified disease characterized by the coexistence of an epidermal nevus with sebaceous differentiation arranged along Blaschko lines and a speckled lentiginous nevus showing a checkerboard pattern, mostly in association with various extracutaneous defects. A 52-year-old man presented with asymptomatic ulcerative plaque on his left side of perioral area. A 2 × 2-cm-sized fleshy colored ulceration on his left perioral area was consistent with basal cell carcinoma with nevus sebaceous. Read More

    Forehead galeal pericranial flap for single-staged total upper eyelid reconstruction in sebaceous gland carcinoma excision.
    Int Med Case Rep J 2017 5;10:309-312. Epub 2017 Sep 5.
    Department of Ophthalmology, Florida International University, Herbert Wertheim College of Medicine, Miami, FL, USA.
    Purpose: To present a successful case of single-staged total upper eyelid reconstruction after sebaceous gland carcinoma excision by using forehead galeal pericranial flap.

    Observations: An 80-year-old female with a progressively enlarged left upper eyelid mass presented with ocular irritation, blurred vision, and gritty sensation despite topical antibiotics treatment. This multinodular mass involved the left total upper eyelid, compromised corneal surface integrity, and caused complete ptosis. Read More

    Simultaneous Development of Three Different Neoplasms of Trichilemmoma, Desmoplastic Trichilemmoma and Basal Cell Carcinoma Arising from Nevus Sebaceus.
    Arch Craniofac Surg 2017 Mar 25;18(1):46-49. Epub 2017 Mar 25.
    Department of Pathology, Busan-Baik Hospital, Inje University School of Medicine, Busan, Korea.
    Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneously. Read More

    Pigmented Trichoblastoma of Nose: An Unusual Occurrence.
    J Clin Diagn Res 2017 Jul 1;11(7):MD09-MD10. Epub 2017 Jul 1.
    Junior Resident, Department of Ear, Nose and Throat, Sri Siddhartha Medical College, Agalakote, Karnataka, India.
    Nevus sebaceus of Jadassohn is a congenital tumour affecting the scalp and face. It is usually presented as a pigmented patch or plaque. It is a complex cutaneous hamartoma which involves pilosebaceous follicle, epidermis and adnexal structures. Read More

    Treatment of Metastatic Eyelid Carcinoma.
    J Craniofac Surg 2017 Nov;28(8):e722-e725
    *Head and Neck Departement, University of Naples Federico II, Naples †Neurosurgery Departement, University of Salerno, Salerno, Italy.
    Purpose: The aim of this study was to report management and outcomes in patients affected by eyelids carcinomas involving regional lymph nodes.

    Methods: We have retrospectively analyzed the data of patients affected by eyelids carcinoma with nodal involvement. The clinical records of 10 patients with malignant eyelid carcinoma and regional nodal metastasis treated between September 2011 and March 2015 have been analyzed. Read More

    Evaluation and comparison of staining patterns of factor XIIIa (AC-1A1), adipophilin and GATA3 in sebaceous neoplasia.
    J Cutan Pathol 2018 Jan 19;45(1):1-7. Epub 2017 Sep 19.
    Department of Pathology, University of South Dakota, Sanford School of Medicine, Sioux Falls, South Dakota.
    Background: Reliable nuclear immunohistochemical stains for sebaceous neoplasms have not been readily available. Positive nuclear staining has been reported for GATA3 and factor XIIIa (AC-1A1). We sought to determine the diagnostic utility of these nuclear stains by comparing their staining pattern to adipophilin, a consistently positive cytoplasmic stain. Read More

    Profile of eyelid malignancy in a Tertiary Health Care Center in North India.
    J Cancer Res Ther 2017 Jul-Sep;13(3):484-486
    Department of Pathology, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.
    Context: The eyelids are affected by wide spectrum of benign and malignant lesions. Basal cell carcinoma (BCC) is the most common malignancy encountered while other malignant lesions such as sebaceous cell carcinoma and squamous cell carcinoma are rare. Data regarding geographical variation in trends of malignant eyelid tumors are presented in the current study. Read More

    Analysis of Sebaceous Neoplasms for DNA Mismatch Repair Proteins in Muir-Torre Syndrome.
    Skinmed 2017 1;15(4):259-264. Epub 2017 Aug 1.
    Department of Dermatology, Walter Reed National Military Medical Center, Bethesda MD.
    Muir-Torre syndrome is a rare genodermatosis inherited most frequently in an autosomal dominant fashion. Current criteria for its diagnosis include at least one sebaceous tumor and an underlying visceral malignancy. Muir-Torre syndrome is strongly associated with a germline mutation in DNA mismatch repair genes. Read More

    Histopathological Analysis of Skin Adnexal Tumors: A Three Year Study of 110 Cases at A Tertiary Care Center.
    Indian J Dermatol 2017 Jul-Aug;62(4):400-406
    Department of Pathology, SawaiMan Singh Medical College, Jaipur, Rajasthan, India.
    Background: Skin adnexal tumors (SAT) encompass wide spectrum of benign and malignant tumors that differentiate toward one or more adnexal structures found in normal skin. Overall incidence of SATs is low yet they can be challenging to diagnose.

    Aims: The aim of this study is to study the spectrum and microscopic features of SATs. Read More

    Sebaceous gland carcinoma of the ocular adnexa - variability in clinical and histological appearance with analysis of immunohistochemical staining patterns.
    Graefes Arch Clin Exp Ophthalmol 2017 Nov 24;255(11):2277-2285. Epub 2017 Jul 24.
    Department of Ophthalmology, University Eye Hospital Bonn, University of Bonn, Ernst-Abbe Str. 2, 53127, Bonn, Germany.
    Purpose: The purpose of the study was to evaluate the characteristics of sebaceous gland carcinoma (SGC) of the ocular adnexae, which is due to a high variability in clinical, histological and immunohistochemical characteristics often challenging to diagnose.

    Methods: Records of six patients with SGC were reviewed, who underwent surgical excision and who were histologically diagnosed with SGC. For comparison, there were specimens from four patients with basal cell carcinoma (BCC) and four patients with squamous cell carcinoma (SCC). Read More

    Surgical Management of Periocular Cancers: High- and Low-Risk Features Drive Treatment.
    Curr Oncol Rep 2017 Sep;19(9):57
    Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1445, Houston, TX, 77030, USA.
    Purpose Of Review: Recent advances in the treatment of eyelid tumors have centered on the excision, evaluation of margins, role of sentinel lymph node biopsy, and adjunctive/adjuvant systemic and radiation therapy. The purpose of this review is to elaborate on these advances.

    Recent Findings: Mohs excision of basal cell carcinoma and squamous cell carcinoma continues to provide the greatest success in complete excision of the cancer, especially in those cases of high-risk disease including medial canthal location and recurrent disease. Read More

    Mismatch repair deficient metastatic colon cancer and urothelial cancer: A case report of sequential immune checkpoint therapy.
    Cancer Biol Ther 2017 Sep 20;18(9):651-654. Epub 2017 Jul 20.
    a Department of Hematology/Oncology , Fox Chase Cancer Center , Philadelphia , USA.
    A major recent advance in cancer therapy involves the use of immune checkpoint therapy for tumors with mismatch repair deficiency, as they have a high tumor mutation load and neoantigen burden. Approximately 4% of advanced colorectal cancer harbors a mismatch repair deficiency. When mismatch repair deficiency exists in the germline, there is increased susceptibility to a variety of cancers including colorectal cancer, uterine cancer, urothelial carcinoma, and skin cancer. Read More

    Sebaceous Differentiation in Squamous Cell Carcinoma of the Larynx and Adjacent Pharynx: Case Report with Review and Discussion of the Literature.
    Head Neck Pathol 2017 Jul 18. Epub 2017 Jul 18.
    Coordinator of the International Head and Neck Scientific Group, Padua, Italy.
    Among the variants of squamous cell carcinoma (SCC) of the head and neck arising in mucosal surfaces, examples with sebaceous differentiation are exceedingly rare. We present a new case of SCC with sebaceous differentiation, developing in the larynx of a 64 year-old male, cigarette smoker and alcohol drinker. The tumor extended transglottically, metastasized to cervical lymph nodes, and killed the patient after 12 months. Read More

    Breast Cancer Metastasis Masquerading as the Great Masquerader: Sebaceous Cell Carcinoma.
    Case Rep Oncol 2017 May-Aug;10(2):485-488. Epub 2017 Jun 6.
    Department of Ophthalmology and Vision Science, University of California Davis Health System, Sacramento, California, USA.
    Objective: We describe the case of a patient with metastatic breast cancer who presented with eyelid margin thickening and madarosis more suggestive of sebaceous cell carcinoma than metastatic disease. Histopathology confirmed metastatic breast adenocarcinoma.

    Case Report: A 59-year-old woman with a known history of metastatic breast carcinoma actively enrolled in a clinical trial presented with a thickened right upper eyelid margin with madarosis and without ulceration. Read More

    Sebaceous Carcinoma: A Review of the Scientific Literature.
    Curr Treat Options Oncol 2017 Aug;18(8):47
    Department of Dermatology, Columbia University Medical Center, New York, NY, 10032, USA.
    Opinion Statement: Sebaceous carcinoma is a rare and potentially aggressive cutaneous malignancy. Commonly reported in the periocular area and the head and neck region, sebaceous carcinoma can arise from any sebaceous gland in the skin. The clinical presentation may be nonspecific, and a biopsy is important to establish a diagnosis and to differentiate from mimickers including benign sebaceous neoplasms, other adnexal tumors, and basal cell carcinoma. Read More

    TdT expression in normal and neoplastic sebaceous cells.
    Histopathology 2017 Dec 19;71(6):985-988. Epub 2017 Sep 19.
    Pathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Aims: Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase expressed in immature, normal and neoplastic, lymphoid or haematopoietic cells and in neuroendocrine carcinomas, such as Merkel cell carcinoma and small-cell carcinoma. It has not yet been described in cells of epithelial origin. After observing TdT immunoreactivity in normal sebaceous glands, we analysed its spectrum of expression in cases of sebaceous cell hyperplasia (SGH) and sebaceous cell neoplasm. Read More

    Sebaceous Carcinoma: Clinicopathologic Analysis of 29 Cases in a Tertiary Hospital in Korea.
    J Korean Med Sci 2017 Aug;32(8):1351-1359
    Department of Dermatology, Chonbuk National University Hospital, Jeonju, Korea.
    Sebaceous carcinoma (SC) is a neoplasm derived from the adnexal epithelium of the sebaceous glands, and most studies on this neoplasm have been conducted in Caucasians. We retrospectively reviewed the records of 29 patients with SC (16 extraocular and 13 ocular lesions) who were diagnosed from 2001 to 2014 to analyze the clinical and histopathological features of SC in the Korean population. Sixteen of the patients were women and 13 were men. Read More

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