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    Application of tegafur gimer, docetaxel and carboplatin in head and neck squamous cell carcinoma therapy.
    Pak J Pharm Sci 2016 Nov;29(6(Special)):2235-2238
    Department of laboratory, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
    Squamous cell carcinoma, in the clinical manifestation, is a form of cancer derived from lesions of keratinocytes of epidermis or accessories such as sebaceous ducts, hair follicles, sweat glands, etc. The disease is more common in older men, with prone locations at patients' scalp, face, neck and arms and other exposed parts. Head and neck squamous cell carcinoma (HNSCC) causes a serious impact on patients' daily life, making patients suffer from double blow in mental and physical aspects and reducing patients' life quality. Read More

    What's New in Eyelid Tumors.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):143-152
    Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY.
    Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, sebaceous cell carcinoma, Merkel cell carcinoma, and melanoma. The gold standard treatment for periocular epithelial malignancies is surgical excision. Read More

    Sox10 and DOG1 Expression in Primary Adnexal Tumors of the Skin.
    Am J Dermatopathol 2017 Mar 27. Epub 2017 Mar 27.
    Departments of*Pathology, and †Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA.
    Primary skin adnexal tumors can be challenging to classify and must be discerned from cutaneous adenocarcinoma metastases from various sites. We evaluated expression of Sox10 and DOG1 in normal cutaneous adnexa and in 194 primary skin adnexal tumors, and compared their performance in discriminating primary skin adnexal tumors from cutaneous metastatic adenocarcinomas with that of p40 and p63. In normal skin adnexa, we noted Sox10 expression in both the secretory and myoepithelial cells in eccrine glands, but only in myoepithelial cells in apocrine glands. Read More

    Expression of Anti-apoptotic Protein BAG3 in Human Sebaceous Gland Carcinoma of the Eyelid.
    Anticancer Res 2017 04;37(4):1931-1934
    Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
    Background: Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), has been shown to play a role in anti-apoptosis of various malignant tumors. In this study, the expression of BAG3 was examined in human sebaceous gland carcinoma of the eyelid.

    Materials And Methods: The expression of BAG3 was evaluated by immunohistochemistry of surgical samples from 5 patients with sebaceous gland carcinoma in the eyelid. Read More

    Multiple viral plaques with sebaceous differentiation associated with an unclassified papillomavirus type in a cat.
    N Z Vet J 2017 Apr 20:1-5. Epub 2017 Apr 20.
    d New Zealand Veterinary Pathology Ltd , Palmerston North , New Zealand.
    CASE HISTORY AND CLINICAL FINDINGS A 15-year-old neutered male domestic short-haired cat was presented due to multiple 0.5-2 cm-diameter crusting plaques in the left preauricular region, over the bridge of nose, and in the right periocular region. The plaques did not appear to cause discomfort. Read More

    Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
    Ophthal Plast Reconstr Surg 2017 Mar 27. Epub 2017 Mar 27.
    *Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, and †Department of Ophthalmology, Tulane University, New Orleans, Louisiana, U.S.A.
    Purpose: To determine the prognostic value of the staging criteria for eyelid tumors in the 7th edition of the American Joint Committee on Cancer (AJCC) staging manual and to determine, for each type of eyelid tumor, which AJCC T categories are associated with increased risk of nodal metastasis and thus potential usefulness of sentinel lymph node biopsy.

    Methods: Systematic review and analysis of articles found by searching PubMed and Google Scholar using the search terms "AJCC," "eyelid," "carcinoma," and "melanoma."

    Results: Rates of local recurrence, regional nodal metastasis, and distant metastasis were approximately 7% to 10%, 1% to 9%, and 0% to 0. Read More

    [Skin cancers in kidney transplant recipients].
    Wiad Lek 2017 ;70(1):68-73
    I Klinika Nefrologii I Transplantologii Z Ośrodkiem Dializ Uniwersytetu Medycznego, Białystok, Polska.
    Kidney transplantation is the best treatment for end-stage renal failure. It prolongs the patient's life, improves quality of life and reduces costs associated with renal replacement therapy. Increasingly, newer immunosuppressive regimens allow for the proper functioning of the transplanted organ for many years. Read More

    GATA3 and MYB Expression in Cutaneous Adnexal Neoplasms.
    Am J Dermatopathol 2017 Apr;39(4):279-286
    *Departments of Pathology, Porto Medical School and Sao Joao Hospital, Porto, Portugal; †Departments of Pathology, William Beaumont School of Medicine, Royal Oak, MI; ‡Departments of Pathology, Duke University Medical Center, Durham, NC; and §Departments of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA.
    Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms. Read More

    Squared-Off Nuclei and "Appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms From 46 Patients.
    Am J Dermatopathol 2017 Apr;39(4):275-278
    *Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany; †Dermatohistology and Oral Pathology Laboratory, Munich, Germany; ‡Department of Pathology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic; §Bioptical Laboratory, Pilsen, Czech Republic; ¶Department of Pathology, University of Texas-MD Anderson Cancer Center, Houston, TX; ‖Department of Pathology, University Medical Center Göttingen, Göttingen, Germany; **Dermatopathology Laboratory, Zurich, Switzerland; and ††Department of Dermatology, University Hospital, Zurich, Switzerland.
    The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called "appliqué" pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the appliqué pattern was observed in a third of the cases. Read More

    MSH6, Past and Present and Muir-Torre Syndrome-Connecting the Dots.
    Am J Dermatopathol 2017 Apr;39(4):239-249
    Dermatopathology Section Chief, Dermatopathology Section, Department of Pathology and Laboratory Medicine (113), VA Consolidated Laboratories, West Roxbury, MA.
    Sebaceous neoplasms such as adenoma, sebaceoma, and carcinoma, although sporadic in their occurrence, are clinically significant because of their association with Muir-Torre syndrome (MTS). MTS is a rare autosomal dominant genodermatosis characterized by the occurrence of sebaceous neoplasms and/or keratoacanthomas and visceral malignancies. MTS is usually the result of germline mutations in the DNA mismatch repair genes MSH2 and, albeit less commonly, MLH1. Read More

    Squamous cell carcinoma arising in a multiple verrucous epidermal nevus.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):166-168
    Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.
    Verrucous epidermal nevi are hamartomatous lesions of the epidermis that, unlike other epidermal nevi (such as sebaceous nevus or nevus comedonicus), are rarely associated with malignant neoplasms. The majority of squamous cell carcinoma develop in linear or multiple epidermal nevus and rarely in solitary epidermal nevus. In general, the prognosis is favorable. Read More

    Primary Cribriform Carcinoma of the Eyelid With Neuroendocrine Features: A Case Report.
    J Drugs Dermatol 2017 Feb;16(2):173-174
    A variety of tumors may involve the eyelid, most of which are primary, but rarely can be metastatic. Previously reported eyelid primary carcinomas with neuroendocrine features include Merkel cell carcinoma, apocrine and eccrine gland carcinoma, sebaceous gland carcinoma, and one report of primary "well-differentiated neuroendocrine tumor." Herein we report the first case of primary cribriform carcinoma of the eyelid with neuroendocrine features. Read More

    Retrospective study of rare cutaneous malignant adnexal tumors of the head and neck in a tertiary care cancer hospital: a case series.
    J Med Case Rep 2017 Mar 12;11(1):67. Epub 2017 Mar 12.
    Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, 7-A, Block-R3, Johar Town, Lahore, Pakistan.
    Background: Adnexal tumors of the skin are a large and diverse group of benign and malignant neoplasms, which exhibit morphological differentiation toward one of the different types of adnexal epithelium present in normal skin and they pose a diagnostic challenge. The purpose of this study is to share our experience with these rare but aggressive tumors at a tertiary care cancer hospital in a developing country. A retrospective review of 11 patients diagnosed with rare adnexal tumors and their variants from January 2005 to December 2014, treated either surgically or non-surgically, was performed to describe the clinicopathological characteristics and outcome of the disease. Read More

    Clinico-Pathological Spectrum of Ophthalmic Lesions: An Experience in Tertiary Care Hospital of Central India.
    J Clin Diagn Res 2017 Jan 1;11(1):EC09-EC13. Epub 2017 Jan 1.
    Assistant Professor, Department of Pathology, Pt. JNM Medical College , Raipur, Chhattisgarh, India .
    Introduction: Ophthalmic lesions show varied distribution on the basis of geographical location. Eye being a unique sensory organ needs to be studied both clinically and pathologically.

    Aim: This study was aimed to evaluate the histomorphological and clinico-pathlological spectrum of ophthalmic lesions at a tertiary care hospital of Central India. Read More

    Topics in histopathology of sweat gland and sebaceous neoplasms.
    J Dermatol 2017 Mar;44(3):315-326
    Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki City, Japan.
    This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Read More

    Sebaceous carcinoma of the breast: a case report.
    Surg Case Rep 2017 Dec 23;3(1):38. Epub 2017 Feb 23.
    Department of Pathology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
    Background: Sebaceous carcinoma of the breast is a distinct variant of invasive ductal carcinoma. It is rare and only several cases have been reported.

    Case Presentation: An 80-year-old woman noted bloody discharge from her left nipple and palpated a lump in her left breast. Read More

    Photodynamic Therapy and Skin Appendage Disorders: A Review.
    Skin Appendage Disord 2017 Jan 8;2(3-4):166-176. Epub 2016 Dec 8.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. Read More

    Sebaceous Carcinoma Arising Within a Nevus Sebaceus Excised by Mohs Micrographic Surgery.
    Dermatol Surg 2017 Feb 17. Epub 2017 Feb 17.
    Department of Dermatology, Houston Methodist Hospital, Houston, Texas The Surgery Center at Plano Dermatology, Plano, Texas Department of Dermatology, Kelsey-Seybold Clinic, Houston, Texas Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

    Malignant tumors associated with ovarian mature teratoma: A single institution experience.
    Pathol Res Pract 2017 Jan 22. Epub 2017 Jan 22.
    Department of Gynecology and Obstetrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
    Objective: The aims of this study are to present demographical features of cases diagnosed with malignant tumor associated with ovarian mature teratoma and to analyze histopathological features and clinical follow up of these tumors.

    Study Design: Single-institution retrospective charts were reviewed to identify all cases of ovarian mature teratoma diagnosed from 1998 to 2015. Clinicopathological parameters that were analyzed include age, tumor size, tumor stage, histological type, laterality, IOC diagnosis and whether or not patient has received adjuvant chemotherapy. Read More

    Reconstructive Surgery of the Upper Eyelid Using the Residual Tarsus after Excision of Sebaceous Gland Carcinoma.
    Case Rep Ophthalmol 2016 Sep-Dec;7(3):308-314. Epub 2016 Dec 28.
    Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
    Purpose: To report a successful eyelid reconstruction performed using the residual tarsus after excision of a sebaceous gland carcinoma.

    Case Report: An 86-year-old woman presented with a sebaceous gland carcinoma of the upper eyelid margin. After excision of the tumor, she underwent reconstructive surgery of the superior eyelid performed using the residual tarsus. Read More

    Sebaceous carcinoma in solid organ transplant recipients.
    Int J Dermatol 2017 Feb 8. Epub 2017 Feb 8.
    Mayo Clinic Arizona, Scottsdale, AZ, USA.
    Background: Though a rare tumor, sebaceous carcinoma is relatively well-described in immunocompetent patients, in whom it often occurs in a periorbital distribution where it has an overall poor prognosis with a high metastasis rate. The effect of transplant-related immunosuppression on the development of sebaceous carcinoma and its outcomes has not been characterized.

    Methods: We collected 9 cases from a single institution of patients developing sebaceous carcinoma after solid organ transplantation. Read More

    Sebaceous Carcinoma Treated With Mohs Micrographic Surgery.
    Dermatol Surg 2017 Feb;43(2):281-286
    *Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York;†Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri.
    Background: Sebaceous carcinoma is a rare and potentially aggressive adnexal neoplasm with historic data indicating high rates of recurrence, metastasis, and cancer-specific mortality.

    Objective: To evaluate the incidence of local recurrence, metastasis, disease-specific mortality, and all-cause mortality and to identify work-up approaches.

    Patients And Methods/materials: Retrospective review of patients with sebaceous carcinoma treated with Mohs micrographic surgery between 2001 and 2013 at one institution. Read More

    Outcome of Flap Surgeries in Dermatosurgical Unit at a Tertiary Care Centre in India with a Review of Literature.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):226-231
    Department of Dermatology, Bangalore Medical College and Research Institute, Victoria Hospital, Bengaluru, Karnataka, India.
    Introduction: Flap surgeries are an excellent choice for closing large defects following trauma, excision of carcinomas or removal of large lesions. This article is a prospective interventional study of various flap surgeries performed at a tertiary care centre with their outcome in dermatosurgical unit.

    Materials And Methods: A total of 35 flap surgeries performed from January 2012 to December 2014 formed part of the study. Read More

    Muir-Torre syndrome caused by exonic deletion of MLH1 due to homologous recombination.
    Eur J Dermatol 2017 Feb;27(1):54-58
    Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
    Background: Muir-Torre syndrome (MTS) is characterized by sebaceous neoplasms with internal malignancies and regarded as a variant of hereditary nonpolyposis colorectal cancer (HNPCC). Pathogenic variations of MTS have been identified in the MSH2, MLH1, and MSH6 genes, with the majority of variations located in MSH2.

    Objectives: To present an MTS patient who was the only individual with skin malignancies within a cancer-prone pedigree and to show the usefulness of RNA-based genetic analysis in the investigation of MTS. Read More

    miRNA-200c and miRNA-141 as potential prognostic biomarkers and regulators of epithelial-mesenchymal transition in eyelid sebaceous gland carcinoma.
    Br J Ophthalmol 2017 Apr 24;101(4):536-542. Epub 2017 Jan 24.
    Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
    Background: MicroRNA (miRNA)-200c and miRNA-141 are tumour suppressors, which regulate epithelial-mesenchymal transition (EMT), leading to tumour invasion and metastasis in various malignancies. miRNA-200c and miRNA-141 maintain the epithelial phenotype by post-transcriptionally inhibiting the E-cadherin repressors, zinc finger E-box binding homeobox (ZEB)1 and ZEB2. The present study was performed to determine the prognostic significance of miRNA-200c and miRNA-141, and their association with EMT markers ZEB1, ZEB2 and E-cadherin in eyelid sebaceous gland carcinoma (SGC). Read More

    MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors.
    J Cutan Pathol 2017 May 14;44(5):444-450. Epub 2017 Feb 14.
    Departments of Dermatology and Pathology, University of California, San Francisco, California.
    Background: Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors. Read More

    High Resolution Diffusion-Weighted Imaging for Solitary Orbital Tumors : 3D Turbo Field Echo with Diffusion-Sensitized Driven-Equilibrium (DSDE-TFE) Preparation Technique.
    Clin Neuroradiol 2017 Jan 17. Epub 2017 Jan 17.
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan.
    Purpose: To differentiate cystic from solid solitary intraorbital tumors using 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation without contrast material.

    Materials And Methods: This retrospective study was approved by our institutional review boards, and written informed consent was waived. A total of 26 patients with intraorbital tumors were studied. Read More

    Distinct expression profile of stem cell markers, LGR5 and LGR6, in basaloid skin tumors.
    Virchows Arch 2017 Mar 9;470(3):301-310. Epub 2017 Jan 9.
    Department of Pathology, Seoul National University College of Medicine, 28 Yeongeon-dong, Seoul, 110-799, South Korea.
    Mammalian epidermis, which is composed of hair follicles, sebaceous glands, and interfollicular epidermis, is maintained by discrete stem cells. In vivo lineage tracing demonstrated that murine LGR5 cells are mainly responsible for hair follicle regeneration whereas LGR6 cells generate sebaceous glands and interfollicular epidermis. However, little is known about their expression in the human skin tumors. Read More

    Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer.
    Plast Reconstr Surg 2017 Jan;139(1):181e-190e
    New York, N.Y. From the Dermatology Service and the Plastic Surgery Service, Memorial Sloan Kettering Cancer Center.
    Learning Objectives: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Read More

    Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.
    Dermatol Surg 2017 Jan;43(1):116-124
    *Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.
    Background: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data.

    Objective: To determine the incidence of several rare nonmelanoma skin cancers. Read More

    Identification of MSH2 inversion of exons 1-7 in clinical evaluation of families with suspected Lynch syndrome.
    Fam Cancer 2016 Dec 21. Epub 2016 Dec 21.
    Clinical Cancer Genetics Program, UT MD Anderson Center, Unit 1354, 1155 Pressler St., Houston, TX, 77030, USA.
    Traditional germline sequencing and deletion/duplication analysis does not detect Lynch syndrome-causing mutations in all individuals whose colorectal or endometrial tumors demonstrate mismatch repair (MMR) deficiency. Unique inversions and other rearrangements of the MMR genes have been reported in families with Lynch syndrome. In 2014, a recurrent inversion of MSH2 exons 1-7 was identified in five families suspected to have Lynch syndrome. Read More

    Mohs micrographic surgery of rare cutaneous tumours.
    J Eur Acad Dermatol Venereol 2016 Dec 15. Epub 2016 Dec 15.
    Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
    Background: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined.

    Objective: To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre.

    Methods & Materials: Retrospective review of all rare cutaneous tumours treated with MMS at a large university centre between January 2008 and December 2012. Read More

    [Therapy options for malignant eyelid tumors].
    Ophthalmologe 2016 Dec;113(12):1095-1108
    Augenklinik mit Poliklinik der Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland.
    Basal cell carcinomas are the most common malignant tumors of the eyelids. Patient history, clinical symptoms and signs, inspection, palpation and slit-lamp examination usually allow a working diagnosis; however, the clinical diagnosis requires histopathological confirmation and determination of the histopathological type. Squamous cell carcinomas, sebaceous gland carcinomas, melanomas and Merkel cell carcinomas can metastasize usually via the lymph vessels into the regional lymph nodes. Read More

    Cutaneous Sebaceous Lesions in a Patient With MUTYH-Associated Polyposis Mimicking Muir-Torre Syndrome.
    Am J Dermatopathol 2016 Dec;38(12):915-923
    *Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Prague, Czech Republic; †Bioptical Laboratory, Pilsen, Czech Republic; and ‡Department of Dermatology, Regional Hospital, Sumperk, Czech Republic.
    A 76-year-old white male with a history of adenocarcinoma of the rectosigmoideum and multiple colonic polyps removed at the age of 38 and 39 years by an abdominoperitoneal amputation and total colectomy, respectively, presented with multiple whitish and yellowish papules on the face and a verrucous lesion on the trunk. The lesions were surgically removed during the next 3 years and a total of 13 lesions were investigated histologically. The diagnoses included 11 sebaceous adenomas, 1 low-grade sebaceous carcinoma, and 1 squamous cell carcinoma. Read More

    Sebaceous carcinoma of the vulva: A case report and review of the literature.
    Gynecol Oncol Rep 2016 Nov 29;18:40-41. Epub 2016 Oct 29.
    University of North Carolina at Chapel Hill, Gynecologic Oncology, United States; University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, United States.
    •Sebaceous carcinoma (SC) is rare with only nine cases reported in the literature.•Extraocular SC likely has similar prognosis to ocular SC.•Reporting of vulvar SC should include detailed pathologic information so that risk factor associations can be made. Read More

    Unusual Presentation of Ulcerative Postauricular Swelling as Sebaceous Cell Carcinoma.
    Niger J Surg 2016 Jul-Dec;22(2):127-129
    Department of General Surgery, Government Medical College, Patiala, Punjab, India.
    Sebaceous glands have high concentration over head and neck region. Despite high concentration, sebaceous cell adenoma and carcinomas are infrequent. Sebaceous cell carcinoma is an uncommon, cutaneous aggressive tumor arising from the sebaceous glands and seen almost exclusively on the eyelids (75%). Read More

    Histopathologic pitfalls of Mohs micrographic surgery and a review of tumor histology.
    Wien Med Wochenschr 2016 Nov 10. Epub 2016 Nov 10.
    Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Università Degli Studi "G. Marconi", Rome, Italy.
    Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Read More

    Generational Expression of Muir-Torre Syndrome in a Canadian Family.
    Case Rep Dermatol Med 2016 16;2016:1712527. Epub 2016 Oct 16.
    Department of Biomolecular Sciences, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON, Canada.
    Muir-Torre syndrome (MTS) is a rare autosomal dominant inherited genodermatosis that is considered to be a phenotypic subtype of hereditary nonpolyposis colorectal cancer (HNPCC), commonly referred to as Lynch syndrome. We describe the clinical course of a 57-year-old female patient with MTS. She has a confirmed HMSH2 mutation. Read More

    Cutaneous Horn of the Eyelid in 13 Cases.
    Ophthal Plast Reconstr Surg 2016 Nov 2. Epub 2016 Nov 2.
    *Ocular Oncology Service and †Department of Ophthalmic Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
    Introduction: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid.

    Objective: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. Read More

    [Muir-Torre syndrome associated with Waldenstrom's macroglobulinemia].
    Ann Dermatol Venereol 2016 Dec 19;143(12):825-830. Epub 2016 Oct 19.
    Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67000 Strasbourg, France.
    Background: Muir-Torre syndrome (MTS), a cutaneous variant of Lynch syndrome, consists of hereditary predisposition to cutaneous tumours and gastrointestinal and gynaecological neoplasms, with autosomal dominant transmission. It is associated with mutations in genes coding for proteins in the DNA mismatch repair system.

    Patients And Methods: Herein, we report a case of a male patient presenting Waldenstrom's macroglobulinemia since the age of 50 and which, after the age of 65 years, developed into sebaceous tumours (5 sebaceous adenomas, 1 sebaceoma, 1 sebaceous carcinoma) and colonic lesions (4 adenomas). Read More

    Orbital exenteration for advanced periorbital non-melanoma skin cancer: prognostic factors and survival.
    Eye (Lond) 2017 Mar 21;31(3):379-388. Epub 2016 Oct 21.
    Department of Ophthalmology, Division of Oculoplastic Surgery, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
    PurposeTo describe prognostic factors and survival outcomes in patients who underwent orbital exenteration for periocular non-melanoma cutaneous malignancies.MethodsThe authors performed an institutional review board-approved retrospective review of all patients who underwent orbital exenteration for non-melanoma periocular cutaneous malignancies at a tertiary care hospital system over a 10-year period. Patient demographics, tumor, and treatment data were recorded. Read More

    Extraocular Sebaceous Carcinoma-A Clinicopathologic Reassessment.
    Am J Dermatopathol 2016 Nov;38(11):809-812
    Department of Dermatology, University of Puerto Rico School of Medicine, San Juan, PR.
    Sebaceous carcinoma is an aggressive adnexal neoplasm with sebaceous differentiation. Few reports have described the histopathologic characteristics of the sebaceous carcinoma occurring extraocularly. Seventy-two cases of extraocular sebaceous carcinoma were identified from the database of a Dermatopathology Laboratory from January 1, 2007 to May 31, 2013. Read More

    Syringocystadenoma Papilliferum of the Scalp Arising from a Nevus Sebaceous.
    J Cutan Aesthet Surg 2016 Jul-Sep;9(3):204-206
    Department of General Surgery, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
    Syringocystadenoma papilliferum (SCAP) is a rare, benign tumour with varied presentations that arises from the apocrine glands and at times can lead to a diagnostic dilemma. A 53-year-old male presented with a 40-year history of a scalp nodule and a recent 2-year change in its character, and a sanguinopurulent discharge. Examination revealed a 4 cm × 2 cm firm nodule upon left side of the scalp vertex, actively discharging pus and blood. Read More

    The role of DOG1 immunohistochemistry in dermatopathology.
    J Cutan Pathol 2016 Nov 5;43(11):974-983. Epub 2016 Sep 5.
    Department of Diagnostic Pathology, Kainan Hospital, Yatomi, Japan.
    Background: This study was designed to evaluate the immunoexpression of DOG1, a specific marker expressed in gastrointestinal stromal tumors, in normal skin tissues and cutaneous epithelial tumors.

    Methods: DOG1 immunostaining extent, intensity and pattern were evaluated in 69 cutaneous apocrine/eccrine tumors, 11 sebaceous tumors, 46 follicular tumors, 52 keratinocytic tumors and perilesional normal tissues.

    Results: In normal tissues, DOG1 was expressed strongly in the intercellular canaliculi of eccrine glands, moderately in the myoepithelial cells of mammary and anogenital mammary-like glands, and weakly or not at all in the periphery of sebaceous lobules and the lower layer of epidermis and follicular infundibulum. Read More

    Nevus Sebaceous of Jadassohn With Eight Secondary Tumors of Follicular, Sebaceous, and Sweat Gland Differentiation.
    Am J Dermatopathol 2016 Nov;38(11):861-866
    *Shanghai Skin Disease Hospital, Tongji University, Shanghai, China †Ackerman Academy of Dermatopathology, New York, NY ‡Department of Dermatology, Kasr Alainy Faculty of Medicine, Cairo University, Egypt.

    Perineural Spread in Squamous Cell Carcinoma of the Face: An Overlooked Facet of Information on Imaging.
    J Maxillofac Oral Surg 2016 Sep 14;15(3):390-393. Epub 2015 Apr 14.
    Department of Radiology, Head and Neck Surgery, Narayana Multispeciality Hospital and Mazumdar Shaw Cancer Centre, Bommasandra, Bangalore, India.
    A case of malignant cutaneous lesion of the face diagnosed initially as sebaceous carcinoma, subsequently proven to be squamous cell carcinoma is presented. Patient was initially evaluated at an outside institution by computed tomography, which indicated extension of lesion to the maxillary sinus. Patient underwent local resection. Read More

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