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    1 OF 41

    Malpractice Litigation in Ocular Oncology.
    Ocul Oncol Pathol 2018 Apr 30;4(3):135-140. Epub 2017 Sep 30.
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
    Aims: The aim of this study was to report and analyze the causes and outcomes of ocular oncology malpractice litigation.

    Methods: The WestLaw® database was reviewed for all litigation related to ophthalmology in the United States from 1930 to 2014. All ocular oncology cases were included in this analysis and compared to other ophthalmic subspecialties. Read More

    MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma.
    Sci Rep 2018 May 14;8(1):7531. Epub 2018 May 14.
    Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, UK.
    Sebaceous gland carcinoma (SGC) is a rare, but life-threatening condition with a predilection for the periocular region. Eyelid SGC can be broadly categorised into two subtypes, namely either nodular or pagetoid with the latter being more aggressive and requiring radical excision to save life. We have identified key altered microRNAs (miRNA) involved in SGC shared by both subtypes, hsa-miR-34a-5p and hsa-miR-16-5p. Read More

    Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma.
    Nat Commun 2018 May 14;9(1):1894. Epub 2018 May 14.
    Department of Dermatology, University of California, San Francisco, CA, 94115, USA.
    Sebaceous carcinomas (SeC) are cutaneous malignancies that, in rare cases, metastasize and prove fatal. Here we report whole-exome sequencing on 32 SeC, revealing distinct mutational classes that explain both cancer ontogeny and clinical course. A UV-damage signature predominates in 10/32 samples, while nine show microsatellite instability (MSI) profiles. Read More

    Bowen Disease With Sebaceous Differentiation: A Case Report and Immunohistochemical Analysis of Adipophilin and Cytokeratin 1.
    Am J Dermatopathol 2018 May 3. Epub 2018 May 3.
    Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki, Japan.
    Bowen disease with sebaceous differentiation has been rarely documented to date. Here, we present a case of Bowen disease with sebaceous differentiation. A 67-year-old man presented with a 6. Read More

    Ocular sebaceous gland carcinoma: an update of the literature.
    Int Ophthalmol 2018 Apr 25. Epub 2018 Apr 25.
    The Operation Eyesight, Universal Institute for Eye Cancer (MVC, SK), L V Prasad Eye Institute, Hyderabad, 500034, India.
    Purpose: To review and summarize the newest update on ocular sebaceous gland carcinoma (SGC) focusing on diagnosis and treatment.

    Methods: A PubMed search was carried out using the terms "Sebaceous Carcinoma", "Meibomian Gland Carcinoma", "Sebaceous Cell Carcinoma", and "Sebaceous Gland Carcinoma". All studies published in English up to October 2017 were included in this review. Read More

    Cutaneous Metastasis Leading to the Diagnosis of Carcinoma of the Prostate: A Rare Case Report and Review of Literature.
    Indian J Dermatol 2018 Mar-Apr;63(2):182-185
    Department of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat, India.
    Prostate adenocarcinoma is a common urologic malignant neoplasm in man. Distant cutaneous metastases (CMs) of prostate carcinoma are extremely rare with a reported incidence of 0.36% and usually they occur late. Read More

    Intraoperative Adjunctive Mitomycin C and Cryotherapy for Recurrent Conjunctival Papillary Sebaceous Carcinoma.
    Case Rep Ophthalmol 2018 Jan-Apr;9(1):221-226. Epub 2018 Mar 22.
    Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    Purpose: To report a case of recurrent conjunctival papillary sebaceous carcinoma that was successfully treated by a combination of surgical resection, intraoperative topical mitomycin C application, and cryotherapy.

    Observations: A woman in her 80s developed a yellowish papillary tumor pedunculated from the surface of the upper palpebral tarsal conjunctiva in her left eye. She was histopathologically diagnosed as having sebaceous carcinoma by an excisional biopsy. Read More

    Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the milan system for reporting salivary gland cytopathology.
    Cancer Cytopathol 2018 Apr 18. Epub 2018 Apr 18.
    Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona.
    Background: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. Read More

    Conjunctival Lesions: When Should We Perform Biopsy?
    Nepal J Ophthalmol 2017 Jul;9(18):160-169
    Introduction: The conjunctiva is a thin and flexible mucus membrane that provides a protective barrier for the eye. Very few histopathologic studies have been conducted on biopsies from conjunctival lesions (CL) in central India.

    Objective: To study the spectrum of CL and define those lesions that need attention with regard to need of biopsy in order to prevent grave sequelae and ocular morbidity. Read More

    Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection.
    Appl Immunohistochem Mol Morphol 2018 Apr 7. Epub 2018 Apr 7.
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
    Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions. Read More

    Basaloid Follicular Hamartoma: A Case Report and a Novel Cosmetic Treatment.
    J Clin Aesthet Dermatol 2018 Mar 1;11(3):39-41. Epub 2018 Mar 1.
    Dr. Segars is with NSU-COM/Largo Medical Center Dermatology Residency in Largo, Florida.
    Basaloid follicular hamartoma (BFH) is a rare, benign neoplasm of the hair follicle, characterized by multiple brown papules involving the face, scalp, and trunk. It is described by multiple clinical forms, and can present as localized or generalized. Diagnosis is made histologically via biopsy, which is important in order to distinguish BFH from basal cell carcinoma (BCC) or other malignant epithelial neoplasms. Read More

    Sebaceous carcinoma of the breast in a patient with a pathogenic BRCA2 (886delGT) mutation - focus on histopathologic and immunohistochemical features.
    APMIS 2018 Apr;126(4):353-356
    Department of Pathology, Chicago Medical School, North Chicago, IL, USA.
    Sebaceous carcinoma of the breast (SCB) is a rare variant of ductal carcinoma arising within the mammary gland and containing at least 50% of malignant cells with sebaceous differentiation. Only 11 cases that adjust to the criteria delineated in the WHO classification have been published in the English literature, to the best of our knowledge. Here, we present the first SCB arising in the context of a deleterious BRCA2 mutation, focusing on the histopathologic and immunohistochemical features of this exceedingly rare tumor. Read More

    Eyelid sebaceous gland carcinoma: Varied presentations and reconstruction outcome.
    Oman J Ophthalmol 2018 Jan-Apr;11(1):21-27
    Department of Pathology, Jawaharlal Nehru Medical College, AMU, Aligarh, Uttar Pradesh, India.
    Purpose: To analyze varying clinical presentations, histopathological features, and management outcome of sebaceous gland carcinoma (SGC) of the eyelid.

    Materials And Methods: We retrospectively reviewed medical records of 30 patients with histologically proven cases of SGC of eyelid treated at tertiary care hospital.

    Results: Patients were in the age group of 28-80 years, among which 18 (60%) were females and 12 (40%) were males. Read More

    Cumulative risk of skin tumours in patients with Lynch syndrome.
    Br J Dermatol 2018 Mar 15. Epub 2018 Mar 15.
    Department of Gastroenterology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
    Lynch syndrome (LS) is an autosomal-dominant disorder characterized by a predisposition to colorectal cancer and extracolonic malignancies. LS is caused by a germline mutation in one of the four DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6 and PMS2) or loss of expression of MSH2 due to deletion in the EPCAM gene. Muir-Torre syndrome (MTS) is considered a variant of LS, in which patients present with sebaceous neoplasms and/or keratoacanthomas. Read More

    Cutaneous horn: A mask to underlying malignancy.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S87-S90
    Department of Oral Pathology, Manubhai Patel Dental College, Vadodara, Gujarat, India.
    Cutaneous horns () are uncommon lesions consisting of keratotic material resembling that of an animal horn. It is a conical- or cylindrical-shaped excessive hyperkeratosis of variable size ranging from few millimeters to several centimeters with a variable in size and shape, such as cylindrical, conical, pointed, transversely or longitudinally corrugated, or curved like a ram's horn. The lesions typically occur in sun-exposed areas, particularly the face, ear, nose, forearms and dorsum of hands. Read More

    Keratinizing pleomorphic adenoma: An unusual case report.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S69-S72
    Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.
    Pleomorphic adenoma (PA) is the most common benign tumor of major or minor salivary glands. PA exhibits a great histological diversity, such as differentiation into oncocytic, sebaceous, mucinous, squamous, chondroid, osseous or adipose cells. Squamous metaplasia rarely results in the formation of extensive keratin-filled cyst lined by squamous epithelium. Read More

    Immunohistochemical evaluation of stress-responsive protein sestrin2 and its correlation with p53 mutational status in eyelid sebaceous gland carcinoma.
    Br J Ophthalmol 2018 Jun 24;102(6):848-854. Epub 2018 Feb 24.
    Department of Zoology, Sri Venkateswara College, University of Delhi, New Delhi, India.
    Background: p53 is a stress-activated tumour suppressor gene, and its mutation has been associated with solid tumours including non-melanoma skin cancers. Sestrin2 expression is associated with DNA damage and oxidative stress and has been described as a downstream target of p53 network. However, its role in sebaceous gland carcinoma (SGC) remains unexplored. Read More

    14-year case series of eyelid sebaceous gland carcinoma in Chinese patients and review of management.
    Br J Ophthalmol 2018 Feb 19. Epub 2018 Feb 19.
    Department of Ophthalmology, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, China.
    Aims: Sebaceous gland carcinoma (SGC) of the eyelid is a rare but potentially deadly cancer. The purpose of this study was to determine whether the American Joint Committee on Cancer (AJCC) 7th Edition T category for SGC correlated with metastasis and survival in the Chinese population.

    Methods: This was a retrospective, single-centre cohort study. Read More

    Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells.
    Histopathology 2018 Jun 25;72(7):1199-1208. Epub 2018 Mar 25.
    Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
    Aims: A number of homeobox transcriptional factors are utilised as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is expressed specifically in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms.

    Methods And Results: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be expressed specifically in the skin. Read More

    GATA3 staining in primary cutaneous apocrine cribriform carcinoma: Usefulness to differentiate it from breast cancer metastasis.
    J Cutan Pathol 2018 May 12;45(5):348-351. Epub 2018 Mar 12.
    Dermatopathology Department, Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
    Background: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raises a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer.

    Objective: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test its usefulness to differentiate this tumor from metastatic breast cancer.

    Methods: We retrieved 14 cases with PCACC (each from a different patient) from the files of the authors. Read More

    Analysis of hedgehog signaling in periocular sebaceous carcinoma.
    Graefes Arch Clin Exp Ophthalmol 2018 Apr 8;256(4):853-860. Epub 2018 Feb 8.
    Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts & London School of Medicine, 4 Newark St, London, E1 2AT, UK.
    Purpose: Sebaceous carcinoma (SC) is a clinical masquerader of benign conditions resulting in significant eye morbidity, sometimes leading to extensive surgical treatment including exenteration, and even mortality. Little is known about the genetic or molecular basis of SC. This study identifies the involvement of Hedgehog (Hh) signaling in periocular SC. Read More

    Cutaneous metastasis of a primary oesophageal adenocarcinoma to the right cheek.
    J Surg Case Rep 2017 Sep 18;2017(9):rjx181. Epub 2017 Sep 18.
    Department of Oral and Maxillofacial Surgery, Royal Albert Edward Infirmary, Wigan, England, UK.
    This case report details of a case of cutaneous metastasis from a primary adenocarcinoma of the oesophagus to the right cheek. A 67-year-old male was referred to the maxillofacial department with a 2-3 week history of non-painful swelling of the cheek. A diagnosis of infected sebaceous cyst was made and drainage was attempted with adjunctive antibiotic therapy. Read More

    Rare desmoplastic trichilemmoma associated with sebaceous nevus.
    An Bras Dermatol 2017 Nov-Dec;92(6):836-837
    Private Clinic - São Paulo (SP), Brazil.
    Nevus sebaceous of Jadassohn is a congenital hamartoma that usually affects the scalp and face. Several benign or malignant neoplasias may develop in the lesion and the most common are trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma. Trichilemmoma is a benign solid tumor originating from external sheath cells of pilosebaceous follicles. Read More

    Microcystic adnexal carcinoma with sebaceous differentiation: Three cases.
    J Cutan Pathol 2018 Apr 15;45(4):290-295. Epub 2018 Feb 15.
    Private Practice, Friedrischafen, Friedrichshafen Dermatopathologie, Friedrischafen, Germany.
    Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. Read More

    Chemical imaging of aggressive basal cell carcinoma using time-of-flight secondary ion mass spectrometry.
    Biointerphases 2018 Jan 12;13(3):03B402. Epub 2018 Jan 12.
    Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg 412 96, Sweden.
    A set of basal cell carcinoma samples, removed by Mohs micrographic surgery and pathologically identified as having an aggressive subtype, have been analyzed using time-of-flight secondary ion mass spectrometry (SIMS). The SIMS analysis employed a gas cluster ion beam (GCIB) to increase the sensitivity of the technique for the detection of intact lipid species. The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface. Read More

    The limitations of dermoscopy: false-positive and false-negative tumours.
    J Eur Acad Dermatol Venereol 2018 Jan 5. Epub 2018 Jan 5.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. Read More

    Case report repairing orbital skin defects using composite flaps after giant eyelid-derived tumor excision and orbital exenteration.
    Medicine (Baltimore) 2017 Dec;96(48):e8978
    Department of Ophthalmology, Second Hospital of JiLin University, ChangChun.
    Rationale: Though giant malignant tumors arising in the eyelid are rare, they often require extensive surgery for removal along with orbital exenteration. Because of this, repairing orbital defects is an important factor in the surgical strategy.

    Patient Concerns: Case 1 was a 78-year-old nomad man who presented in the Department of Ophthalmology with a giant tumor in his right eyelid, which had developed over three years. Read More

    Cutaneous Metaplastic Carcinoma: Report of a Case With Sebaceous Differentiation.
    Am J Dermatopathol 2017 Dec 28. Epub 2017 Dec 28.
    Department of Dermatology, Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP), São Paulo, Brazil.
    In this study, a case of a 56-year-old woman with cutaneous metaplastic carcinoma in the neck is reported. It harbored basal cell carcinoma, squamous cell carcinoma, and sebaceous carcinoma, as well as osteosarcoma (with fibroblastic, osteoblastic, aneurysmal bone cyst-like, and chondroblastic patterns). To our knowledge, the literature does not mention sebaceous carcinoma in cutaneous metaplastic carcinoma. Read More

    Intraoral Pigmented Low-Grade Adenocarcinoma, Not Otherwise Specified: Case Report and Immunohistochemical Study.
    Head Neck Pathol 2017 Dec 22. Epub 2017 Dec 22.
    Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Avenida do Café, S/N, Ribeirão Preto, São Paulo, 14040-904, Brazil.
    Salivary adenocarcinoma, not otherwise specified (AdCaNOS) is a rare malignant tumor with potential diagnostic challenge, which mainly affects the parotid glands; however, the minor salivary glands can also be involved by AdCaNOS. This paper reports a case of a 45-year-old Afro-descendant woman complaining of a slow-growing mass with 6 months of evolution in the left superior vestibular fornix. Microscopic examination revealed an infiltrative epithelial neoplasm composed of predominantly solid growth pattern, arranged in a lobular configuration, admixed with glandular or ductal structures. Read More

    Extraocular sebaceous carcinoma accompanied by invasive squamous cell carcinoma: The first case report and consideration of histogenesis.
    J Dermatol 2018 Apr 21;45(4):501-504. Epub 2017 Dec 21.
    Department of Dermatology, Kansai Medical University, Osaka, Japan.
    A 61-year-old man presented with a dome-shaped nodule, 1.2 cm in size, with a central crater covered by keratinous material near the left lateral malleolus. Histological findings demonstrated a basophilic circular cone in the center, surrounded and sharply demarcated by a broad eosinophilic area. Read More

    Dermoscopic features distinctive for extraocular sebaceous carcinoma.
    J Dermatol 2018 Apr 13;45(4):487-490. Epub 2017 Dec 13.
    Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
    We examined dermoscopic features of three cases of extraocular sebaceous carcinoma and reviewed the literatures. The yellowish structures, polymorphous vessels and ulceration were common findings in our cases and all cases of the previous reports. The appearance of whitish-pink areas has not been described previously. Read More

    Dermatological Complications After Solid Organ Transplantation.
    Clin Rev Allergy Immunol 2018 Feb;54(1):185-212
    Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
    Organ transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e. Read More

    Immunohistochemical expression of X-linked inhibitor of apoptosis in eyelid sebaceous gland carcinoma predicts a worse prognosis.
    Indian J Ophthalmol 2017 Nov;65(11):1109-1113
    Department of Ocular Pathology, Dr. R. P. Centre, AIIMS, New Delhi, India.
    Purpose: Overexpression of the inhibitors of apoptosis proteins have been demonstrated in a variety and of solid tumors including melanomas and nonmelanomas skin cancers. X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of apoptosis which prevents apoptosis by inhibiting caspases 9, 7, and 3. The prognostic value of XIAP in sebaceous gland carcinoma (SGC) remains unexplored. Read More

    Cutaneous metastasis of renal cell carcinoma masquerading as an infected sebaceous cyst.
    J Stomatol Oral Maxillofac Surg 2018 Apr 8;119(2):145-147. Epub 2017 Nov 8.
    Department of Urology, Christian Medical College, Vellore, India.
    Renal cell carcinoma (RCC) is the third most common genitourinary malignancy with an estimated one third of cases with metastatic disease at the time of diagnosis. Though rare, cutaneous metastasis from RCC is more frequent than any other genitourinary malignancy. Metastasis of RCC to skin carries poor prognosis as coexistent visceral spread is the norm. Read More

    Basal Cell Carcinoma of Vermilion Mucosa of Upper Lip: a Rare Case Report.
    Acta Med Indones 2017 Jul;49(3):255-258
    Department of Dermatology, Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Although basal cell carcinoma (BCC) is a common skin tumor, very rare cases of BCC arising from upper vermilion mucosa of lip have been reported previously. This tumor basically, originates from pillar structures and the involvement of the vermilion lip contrasts this concept so it is devoid of hair follicles and sweat glands. The exact pathogenesis of vermilion lip BCC is not clear but it has been postulated that the neoplasm originates from the pluripotential epithelial cells of the oral mucosa and epidermis. Read More

    Immunohistochemical markers informing the diagnosis of sebaceous carcinoma and its distinction from its mimics: Adipophilin and factor XIIIa to the rescue?
    J Cutan Pathol 2018 Jan;45(1):29-32
    Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Sebaceous carcinoma typically presents a diagnostic challenge because it mimics other more common, locally invasive carcinomas, including squamous cell carcinoma and basal cell carcinoma-particularly when one of these tumors exhibits concomitant clear-cell changes. Immunohistochemical studies offering high sensitivity and specificity are critical for accurate diagnosis. Read More

    Reticulated acanthoma with sebaceous differentiation mimicking melanoma.
    Dermatol Pract Concept 2017 Jul 31;7(3):35-37. Epub 2017 Jul 31.
    Department of Dermatology, Mogi das Cruzes University, Mogi das Cruzes, Brazil.
    Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. Read More

    Sebaceous lesions of the skin.
    Pathology 2017 Dec 25;49(7):688-697. Epub 2017 Oct 25.
    Dermatopathology Group, Department of Anatomical Pathology, PathWest, Perth, Australia; School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia. Electronic address:
    Sebaceous differentiation is commonly seen in cutaneous neoplasms, both in the context of lesions showing predominantly sebaceous differentiation (e.g., sebaceous adenoma, sebaceoma and sebaceous carcinoma), or as more focal sebaceous components in neoplasms with other primary lines of differentiation. Read More

    Histologic Mimics of Basal Cell Carcinoma.
    Arch Pathol Lab Med 2017 Nov;141(11):1490-1502
    From the Departments of Pathology (Drs Stanoszek, Wang, and Harms) and Dermatology (Dr Harms), University of Michigan Medical School, Ann Arbor. Drs Stanoszek and Wang contributed equally.
    Context: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Read More

    Microcystic adnexal carcinoma of the orbit mimicking pagetoid sebaceous gland carcinoma.
    Orbit 2018 Jun 20;37(3):235-237. Epub 2017 Oct 20.
    d Medical Director, MN Eye Hospital , Chennai , India.
    Microcystic adnexal carcinoma (MAC) is a rare malignancy of sweat glands that has been reported most often on the face in the form of a cutaneous lesion, with the potential for deeper invasion. The synonyms of MAC include sclerosing sweat duct carcinoma, syringomatous carcinoma, and malignant syringoma. Clinically, MAC in the periocular area has been misdiagnosed as basal cell carcinoma, squamous cell carcinoma, or even chalazia. Read More

    Sebaceous carcinoma in situ as a concept and diagnostic entity.
    Dermatol Pract Concept 2017 Jul 31;7(3):27-31. Epub 2017 Jul 31.
    Departments of Pathology and Dermatology, Hofstra Northwell School of Medicine, Hempstead, NY, USA.
    Although carcinoma in situ has been accepted as a well-established concept and diagnostic category, for reasons unknown sebaceous carcinoma in situ has not been recognized yet in general pathology or dermatopathology. Such lesions have always been misinterpreted as either benign neoplasm or sebaceous carcinoma. In the present essay, we provide a convincing account supporting sebaceous carcinoma in situ as a valid concept and diagnostic entity via critical literature review and histopathological assessment and illustration. Read More

    [Proliferation of a basal cell carcinoma on a sebaceous nevus of the lower eyelid: Case report of a rare association].
    J Fr Ophtalmol 2017 Nov 21;40(9):e367-e369. Epub 2017 Oct 21.
    Service d'ophtalmologie B de l'hôpital des spécialités, université Mohammed V Souissi, centre hospitalier universitaire, avenue des Nations Unies, Agdal, Rabat, Maroc.

    Disfiguring facial pyoderma vegetans with an excellent outcome.
    BMJ Case Rep 2017 Oct 13;2017. Epub 2017 Oct 13.
    Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
    We describe a case of disfiguring facial pyoderma vegetans in order to highlight the challenges in managing this rare skin condition and review the literature.A 54-year-old woman presented to dermatology clinic with a 3-month history of a left-sided facial lesion, which had been treated as an infected sebaceous cyst. The lesion had dramatically increased in size in the weeks prior to presentation. Read More

    A Case of Phacomatosis Pigmentokeratotica Associated With Multiple Basal Cell Carcinomas.
    Am J Dermatopathol 2018 Feb;40(2):131-135
    Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
    Phacomatosis pigmentokeratotica is a recently identified disease characterized by the coexistence of an epidermal nevus with sebaceous differentiation arranged along Blaschko lines and a speckled lentiginous nevus showing a checkerboard pattern, mostly in association with various extracutaneous defects. A 52-year-old man presented with asymptomatic ulcerative plaque on his left side of perioral area. A 2 × 2-cm-sized fleshy colored ulceration on his left perioral area was consistent with basal cell carcinoma with nevus sebaceous. Read More

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