2,350 results match your criteria Sebaceous Carcinoma

The role of radiation therapy in the management of cutaneous malignancies. Part II: When is radiation therapy indicated?

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Departments of Dermatology and Head and Neck Surgery, The University of Texas MD Anderson Cancer, Houston, Texas, USA.

Radiation therapy may be performed for a variety of cutaneous malignancies depending on patient health status, tumor clinical and histologic features, patient preference, and resource availability. Dermatologists should be able to recognize the clinical scenarios in which radiation therapy is appropriate as this may reduce morbidity, decrease risk of disease recurrence, and improve quality of life. The second article in this 2-part continuing medical education series focuses on the most common indications for radiation therapy in the treatment of basal cell carcinoma, cutaneous squamous cell carcinoma, dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi sarcoma, angiosarcoma, cutaneous lymphoma, melanoma, undifferentiated pleomorphic sarcoma, and sebaceous carcinoma. Read More

View Article and Full-Text PDF

Extraocular Sebaceous Carcinoma Treated With Mohs Micrographic Surgery-A 24-Year Retrospective Review of Tumor Characteristics and Treatment Outcomes.

Dermatol Surg 2021 Jun 7. Epub 2021 Jun 7.

Division of Dermatology and Mohs Surgery, Scripps Clinic, La Jolla, California; Department of Dermatology, Naval Medical Center San Diego, San Diego, California; Department of Medicine, Scripps Mercy Hospital, San Diego, California.

Background: Extraocular sebaceous carcinoma (SC) is rare, with distinct features from its ocular counterpart. These neoplasms have been associated with Muir-Torre syndrome (MTS). Associated internal malignancies include gastrointestinal and genitourinary. Read More

View Article and Full-Text PDF

Sebaceous carcinoma of the chest wall: A case report.

Radiol Case Rep 2021 Jul 25;16(7):1870-1873. Epub 2021 May 25.

Consultant Breast Surgeon Cambridge University Hospital NHS Trust, Cambridge and Anglia Ruskin School of Medicine, Cambridge, UK.

Sebaceous carcinoma is a rare, malignant tumor of the sebaceous glands. This is a case report of a 75-year-old man who presented with a right lower axillary mass which initially was considered to be a benign sebaceous cyst from sonography. The lesion rapidly changed in clinical and sonographic appearances and on histology was a sebaceous carcinoma. Read More

View Article and Full-Text PDF

[Clinicopathological features of basal cell type dysplasia of esophagus].

Zhonghua Bing Li Xue Za Zhi 2021 Jun;50(6):638-644

Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

To investigate the clinicpathological features of basal cell type dysplasia of the esophagus. The clinicopathological data of 71 cases of basal cell type dysplasia of esophagus were collected at the People's Liberation Army Joint Logistics Support Force 989 Hospital, from 2009 to 2019, and the histomorphologic characteristics and immunophenotype were evaluated. The relevant literature was reviewed. Read More

View Article and Full-Text PDF

Clinical and Molecular Features of Skin Malignancies in Muir-Torre Syndrome.

Genes (Basel) 2021 May 20;12(5). Epub 2021 May 20.

Department of Dermatology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.

Background: We investigated the mutational landscape of skin tumors in patients with Muir-Torre Syndrome (MTS) a hereditary autosomal dominant mismatch repair disorder of increased cancer susceptibility, and examined mutations other than in the DNA mismatch repair (MMR) genes.

Methods: This retrospective single-center case series included seven patients with the diagnosis of Muir-Torre Syndrome with precise medical history and family history. Mutational analysis of tumor samples Formalin-fixed paraffin-embedded tissue blocks of skin lesions associated with Muir-Torre Syndrome were used for further analysis. Read More

View Article and Full-Text PDF

Establishment and Characterization of a Novel Human Ocular Adnexal Sebaceous Carcinoma Cell Line.

Transl Vis Sci Technol 2021 May;10(6):34

Dr. Nasser Ibrahim Al-Rashid Orbital Vision Research Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Purpose: Sebaceous carcinoma (SC) is a malignant eyelid tumor of the ocular adnexa that is primarily treated via surgical excision. Few therapies exist in advanced cases, and medical therapy is limited because of our incomplete understanding of SC biology. Herein, we describe a technique to culture human ocular adnexal SC for use as an in vitro model. Read More

View Article and Full-Text PDF

A Case of Muir-Torre Syndrome.

Cureus 2021 Apr 20;13(4):e14582. Epub 2021 Apr 20.

Hematology/Oncology, Henry Ford Health System, Jackson, USA.

Muir-Torre syndrome (MTS) is an autosomal dominant condition characterized by dermatological tumors along with visceral malignancies. The dermatological manifestations include recurrent sebaceous adenomas and keratoacanthomas. The commonly seen visceral malignancies are colorectal, gynecological, and urological. Read More

View Article and Full-Text PDF

Molecular Genetics of Sebaceous Neoplasia.

Jeffrey P North

Surg Pathol Clin 2021 Jun;14(2):273-284

Dermatopathology, Department of Dermatology, University of California San Francisco, School of Medicine, 1701 Divisadero Street, Room 280, San Francisco, CA 94115, USA; Department of Pathology, University of California San Francisco, School of Medicine, 1701 Divisadero Street, Room 280, San Francisco, CA 94115, USA. Electronic address:

Sebaceous neoplasia primarily includes sebaceous adenoma, sebaceoma, and sebaceous carcinoma (SC). Sebaceous adenoma, sebaceoma, and a subset of cutaneous SC are frequently associated with defective DNA mismatch repair resulting from mutations in MLH1, MSH2, or MSH6. These tumors can be sporadic or associated with Muir-Torre syndrome. Read More

View Article and Full-Text PDF

Collision tumor of sebaceous carcinoma and squamous cell carcinoma of the eyelid: Case report.

Eur J Ophthalmol 2021 May 20:11206721211016303. Epub 2021 May 20.

Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi.

Background: Collision tumors are rare clinical entities that two heterogeneous neoplasms are concurrently adjacent to each other at the same location. The association of a squamous cell carcinoma and a malignant adnexal tumor is even infrequent.

Case Presentation: The case of a 79-year-old woman having a slow-growing and painless tumor on the left lower eyelid was presented. Read More

View Article and Full-Text PDF

Sebaceous Cell Carcinoma of the Lower Eyelid in an Elderly Male: a Rare Case Report and Review of Literature.

Indian J Surg Oncol 2021 Apr 23;12(Suppl 1):224-227. Epub 2021 Mar 23.

Department of Radiation Oncology, Sahyadri Hospital, Pune, India.

View Article and Full-Text PDF

Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer.

BMC Cancer 2021 May 13;21(1):547. Epub 2021 May 13.

Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas Gral. José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Ciudad de Buenos Aires, Argentina.

Background: Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species. In this study, we evaluated the in vitro photoactivity of four meso-substituted porphyrins and a porphyrin coupled to a fullerene.

Methods: The cell line employed was the LM3 mammary adenocarcinoma, and the PS with the best photokilling activity was administered to mice bearing the LM3 subcutaneously implanted adenocarcinoma. Read More

View Article and Full-Text PDF

Optical Coherence Tomography of Peri-Ocular Skin Cancers: An Optical Biopsy.

Ocul Oncol Pathol 2021 Mar 2;7(2):149-158. Epub 2020 Dec 2.

The MUHC, McGill University Ocular Pathology and Translational Research Laboratory, McGill University, Montreal, Québec, Canada.

Introduction: Optical coherence tomography (OCT) imaging has been used as a diagnostic tool for retinal disease for several years, and OCT apparatuses are becoming increasingly powerful. However, OCT has yet to reach its full potential in ophthalmology clinics. Alike retinal layers, it has been shown that OCT is able to generate cross-sectional images of the skin and allows visualization of skin lesions in a histopathology-like manner. Read More

View Article and Full-Text PDF

Profile of Ophthalmic Tumors in Adult Nepalese Population in Central Nepal.

Nepal J Ophthalmol 2020 Jul;12(24):270-280

Geta Eye Hospital, Dhangadhi, Nepal.

Introduction: Ophthalmic tumors cover benign and malignant tumors of eyelids, conjunctiva, globe, and orbit. There is limited literature on ophthalmic tumors in Nepal. The objective of the study was to find the relative frequency of various ophthalmic tumors in the adult Nepalese population in Central Nepal. Read More

View Article and Full-Text PDF

Papillary Renal Cell Carcinoma in Lynch/Muir-Torre Syndrome with Germline Pathogenic Variant in and Molecular Analysis: Report of a Case and Review of the Literature.

J Kidney Cancer VHL 2021 21;8(2):8-19. Epub 2021 Apr 21.

Department of Pathology & Immunology.

Lynch syndrome (LS) is an autosomal dominant inherited disorder due to pathogenic variations in the mismatch repair genes, which predisposes to malignancies, most commonly colon and endometrial carcinoma. Muir-Torre syndrome is a subset of LS with cutaneous sebaceous adenoma and keratoacanthoma in addition to the malignancies. Renal cell carcinoma (RCC) in patients with LS is extremely rare. Read More

View Article and Full-Text PDF

A Case Report of Leptomeningeal Carcinomatosis Secondary to Recurrent Merkel Cell Carcinoma after Avelumab.

Perm J 2021 May;25

Kaiser Permanente Riverside Medical Center, Riverside, CA.

Introduction: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cancer with a high mortality rate of 33% to 46%. Merkel cell is a type of epidermis cell receptor responsible for contact sensitivity and is known to have neuroendocrine properties. Treatment of Merkel cell carcinoma with avelumab has been prominsing, but its rarity and poor prognosis necessitates close follow up. Read More

View Article and Full-Text PDF

Single-stage repair of large full thickness lower eyelid defects using free tarsoconjunctival graft and transposition flap: experience and outcomes.

Orbit 2020 Dec 1:1-6. Epub 2020 Dec 1.

Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA.

: Lid-sharing approaches are often advocated for repair of large full thickness lower eyelid defects, however result in temporary visual obstruction and the need for a second-stage procedure. The authors describe and report outcomes using a one-stage technique utilizing a free tarsoconjunctival graft (TCG) and musculocutaneous transposition flap (MCT) to repair defects up to 90% of the lower eyelid.: A retrospective chart review on patients that had undergone full thickness lower eyelid reconstruction using a TCG and MCT between the dates of 1/1/2015 to 3/1/2020 was performed. Read More

View Article and Full-Text PDF
December 2020

Dermoscopic features of sebaceous carcinoma of the nipple.

J Dermatol 2021 May 9. Epub 2021 May 9.

Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

View Article and Full-Text PDF

Treatment-resistant actinic keratoses are characterized by distinct clinical and histological features.

Ital J Dermatol Venerol 2021 Apr;156(2):213-219

Faculty of Health, University Witten-Herdecke, Witten, Germany.

Background: Actinic keratoses (AK) are generally treated to reduce the risk of progression into invasive cutaneous squamous cell carcinoma (cSCC). However, this risk of transformation is low, and rather than focusing on these lesions, current treatment studies report on complete clearance of AKs in an entire field. This study aimed to investigate treatment-resistant AKs (trAK) after field therapy compared to randomly chosen AKs prior to treatment. Read More

View Article and Full-Text PDF

Sebaceous carcinoma arising from sebaceoma.

Arch Craniofac Surg 2021 Apr 29;22(2):126-130. Epub 2021 Apr 29.

Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine, Cheonan, Korea.

Sebaceous neoplasms are rare adnexal tumors that can present a challenge to clinicians. Only four cases of sebaceous carcinoma with sebaceoma have been reported in the literature. Herein, we describe the case of a sebaceous carcinoma originating from a sebaceoma in a solitary nodule of the posterior neck. Read More

View Article and Full-Text PDF

Adipophilin expression in skin lesions with clear cell histology.

J Clin Pathol 2021 May 5. Epub 2021 May 5.

Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Aims: Clear cells formed due to depositions of glycogen or lipids in the cytoplasm commonly occur in various tissues. Adipophilin (ADP), a lipid regulatory protein, is closely related to lipid droplets. This study aims to examine adipophilin expression in clear cells of various skin lesions. Read More

View Article and Full-Text PDF

Comparison of adipophilin and recently introduced PReferentially expressed Antigen in MElanoma immunohistochemistry in the assessment of sebaceous neoplasms: A pilot study.

J Cutan Pathol 2021 May 5. Epub 2021 May 5.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Background: We and others have noticed consistent staining of sebaceous glands with PReferentially expressed Antigen in MElanoma (PRAME). We aimed to determine whether PRAME was as sensitive, specific, and interpretable as adipophilin for distinguishing sebaceous neoplasms (SNs) from other neoplasms.

Methods: Twenty SNs and 32 control cases were stained for PRAME and adipophilin. Read More

View Article and Full-Text PDF

MLH1 epimutation is a rare mechanism for Lynch syndrome: A case report and review of the literature.

Genes Chromosomes Cancer 2021 May 2. Epub 2021 May 2.

Department of Pathology and Laboratory Medicine, Sinai Health System and University of Toronto, Toronto, Ontario, Canada.

Endometrial carcinoma is one of the prototypical malignancies associated with Lynch syndrome, an inherited cancer syndrome most commonly caused by germline mutations in DNA mismatch repair (MMR) genes, although rare alternative mechanisms also exist. In this report, we describe a patient first diagnosed with colorectal cancer at age 33, then vulvar squamous cell carcinoma, facial sebaceous adenoma/sebaceoma, and finally endometrial carcinoma at age 52. All tumors were MLH1/PMS2-deficient by immunohistochemistry, and MLH1 promoter methylation was identified in the endometrial cancer. Read More

View Article and Full-Text PDF

Sebaceous Gland Carcinoma of Lid: Masquerading as a Recurring Chalazion.

Int J Appl Basic Med Res 2021 Apr-Jun;11(2):117-119. Epub 2021 Apr 8.

Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Recurrent chalazion may be associated with bad lid hygiene but can have clinical changes which lead to the suspicion of a more dangerous entity. Particularly in elderly patients, recurrence of chalazion should be suspected to have carcinomatous changes. We present the case of a 52-year-old woman with presentation of recurrent chalazion which turned out to be sebaceous gland carcinoma of the lid. Read More

View Article and Full-Text PDF

A Case of Cutaneous Spindle Cell Squamous Cell Carcinoma Arising in a Nevus Sebaceous.

Ann Dermatol 2020 Apr 11;32(2):170-171. Epub 2020 Mar 11.

Department of Dermatology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

View Article and Full-Text PDF

A modified method for upper eyelid reconstruction with innervated orbicularis oculi myocutaneous flaps and lower lip mucosal grafts.

JPRAS Open 2021 Jun 24;28:131-139. Epub 2021 Mar 24.

Department of Plastic Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan.

Background: Numerous reports have described methods for repairing full-thickness upper eyelid defects using lower eyelid tissue. To avoid sacrificing the lower eyelid and thereby prevent lower eyelid sagging or dysfunction, we used innervated orbicularis oculi myocutaneous flaps harvested from the upper eyelid for upper eyelid reconstruction.

Methods: We modified a method reported by Moschella and Cordova for repairing full-thickness upper eyelid defects using innervated bipedicled orbicularis oculi myocutaneous flaps mobilized from the upper eyelid and labial mucosal grafts. Read More

View Article and Full-Text PDF

An implant-retained auricular prosthesis complicated by a modified temporal bone resection.

J Prosthet Dent 2021 Apr 17. Epub 2021 Apr 17.

Professor Emeritus, Division of Advanced Prosthodontics, UCLA School of Dentistry, Los Angeles, Calif.

A patient underwent a modified temporal bone resection and total auriculectomy to remove a sebaceous carcinoma arising from the tragus of the right auricle that extended into the external auditory meatus. Because the tumor extended into the temporal bone, the osseous sites originally selected for immediate placement of the craniofacial implants were resected and no longer available. Subsequently, after an appropriate period of healing, implants were placed into the residual temporal bone, considerably more superior and posterior to the external auditory meatus such that they emerged through hair-bearing skin. Read More

View Article and Full-Text PDF

Epidemiological Profile and Clinical Stage at Presentation of Eyelid Malignancies in a Multi-Ethnic Country.

J Craniofac Surg 2021 Mar 25. Epub 2021 Mar 25.

Department of Ophthalmology and Visual Sciences, Division of Ophthalmic Plastic and Reconstructive Surgery, Paulista School of Medicine - EPM, Federal University of S. Paulo - UNIFESP, Sao Paulo, Brazil.

Abstract: Eyelid malignancies are frequently seen in clinical practice. There is a lack of studies that have assessed the features of these lesions in mixed population countries. The epidemiologic profile, clinical stage at presentation, management, and outcomes of patients with eyelid malignancies were assessed, in order to better understand the features of these lesions in a multi-ethnic country. Read More

View Article and Full-Text PDF

Cytological Evaluation of Palpebral Lesions: An Insight into its Limitations Aided with Histopathological Corroboration.

J Microsc Ultrastruct 2021 Jan-Mar;9(1):12-17. Epub 2020 Nov 9.

Department of Pathology, North Bengal Medical College and Hospital, Siliguri, West Bengal, India.

Context: Eyelids by virtue of its unique histomorphology give rise to multitudes of different pathological conditions. Appropriate preoperative cytological diagnoses of these cases are necessary to determine their optimal therapy.

Aims: The aims of this study were to evaluate the utility of various cytological techniques in diagnosing the definite pathology for palpebral lesions and thereby to highlight the drawbacks associated with cytology in this context. Read More

View Article and Full-Text PDF
November 2020

Ocular and Periocular Tumors in India: An EyeSmart Electronic Medical Record Analysis of 9633 Cases from a Referral Center.

Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):199-203. Epub 2021 Jan 19.

Department of EyeSmart EMR and AEye (AVD), L V Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To describe the epidemiology of ocular and periocular tumors in patients presenting to a multi-tier ophthalmology hospital network in India using the electronic medical records (EMRs) system.

Methods: A retrospective, observational, referral, hospital-based study of 1,142,098 patients. The data were collected using the in-house developed EyeSmart EMR system. Read More

View Article and Full-Text PDF

Androgen and Estrogen Receptor Expression in Different Types of Perianal Gland Tumors in Male Dogs.

Animals (Basel) 2021 Mar 19;11(3). Epub 2021 Mar 19.

Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-612 Lublin, Poland.

Perianal gland tumors are modified sebaceous glands present in the skin of the perianal region in the dog. Hormonal stimulation may induce hyperplasia of the perianal glands or their neoplastic progression. The presence of androgen (AR) and estrogen (ER) receptors have been demonstrated both in normal perianal glands as well as in perianal tumors. Read More

View Article and Full-Text PDF