2,238 results match your criteria Sebaceous Carcinoma


Sebaceous carcinoma of the eyelid: 21-year experience in a Nordic country.

Acta Ophthalmol 2020 Aug 4. Epub 2020 Aug 4.

Department of Ophthalmology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Purpose: To evaluate the clinical features, diagnostic challenges, management, and prognosis of sebaceous carcinoma (SC) of the eyelids and periocular region in a Nordic country.

Methods: Patients were identified from the Finnish Cancer Registry and the Helsinki University Hospital databases during the 21-year period 1998-2018. Age, sex, location, clinical and histopathologic diagnosis, treatment and outcome were registered. Read More

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http://dx.doi.org/10.1111/aos.14552DOI Listing

Second primary tumors in retinoblastoma survivors: a study of 7 Asian Indian patients.

Int Ophthalmol 2020 Jul 31. Epub 2020 Jul 31.

Operation Eyesight, Universal Institute for Eye Cancer (SK, VARP), L V Prasad Eye Institute, 500034, Hyderabad, India.

Purpose: To assess the incidence, types, and outcomes of second primary tumors (SPT) in cases of retinoblastoma (RB) from a referral Tertiary eye care center METHODS: Retrospective chart review of 7 cases RESULTS: All 7 (100%) cases had bilateral RB at presentation. The mean age at diagnosis of RB was 16 months (median 7 months; range 5-72 months). Treatment of RB with intravenous chemotherapy was noted in 3 (43%) patients, 1 (14%) patient had received external beam radiotherapy (EBRT) to the orbit, 1 (14%) patient had received a combination of chemotherapy and orbital EBRT, while 4 (57%) patients had undergone primary enucleation of the worse eye and focal treatment of the better eye. Read More

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http://dx.doi.org/10.1007/s10792-020-01517-yDOI Listing

High Expression of PD-L1 and PD-L2 in Ophthalmic Sebaceous Carcinoma: The Case for a Clinical Trial of Checkpoint Inhibitors.

Am J Ophthalmol 2020 Jul 27. Epub 2020 Jul 27.

Division of Head and Neck Pathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Purpose: To evaluate the expression of programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2) in ocular adnexal sebaceous carcinoma (OASC), and to appraise these findings within the context of recent comparable studies.

Designs: Retrospective case series.

Methods: Twenty cases of primary OASC were immunostained for PD-L1, PD-L2 and CD8. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.07.031DOI Listing

Ultrasound Imaging of Nevus Sebaceous of Jadassohn.

J Ultrasound Med 2020 Jul 29. Epub 2020 Jul 29.

Department of Pathology, Hospital San Borja Arriaran, Central Campus Faculty of Medicine, Universidad de Chile, Santiago, Chile.

Nevus sebaceous of Jadassohn (NSJ) is a cutaneous hamartoma commonly found in the scalp and face and more frequent in children. Clinically, it presents as a yellowish and hairless plaque. In later stages, the NSJ can develop secondary tumors, including skin cancer. Read More

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http://dx.doi.org/10.1002/jum.15405DOI Listing

Pagetoid Spread of Sebaceous Cell Carcinoma over the Cornea.

Ophthalmology 2020 Aug;127(8):1085

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1016/j.ophtha.2020.04.003DOI Listing

Ophthalmic Technology Assessment - Sentinel Lymph Node Biopsy for Eyelid and Conjunctival Malignancy: A report by the American Academy of Ophthalmology.

Ophthalmology 2020 Jul 19. Epub 2020 Jul 19.

Cullen Eye Institute, Baylor College of Medicine, Houston, Texas.

Purpose: To determine the efficacy and safety of sentinel lymph node biopsy (SLNB) in the management of eyelid and conjunctival malignancy.

Methods: A literature search was performed in August 2019 and January 2020 for articles published in English in the PubMed and Cochrane Library databases. This search yielded 151 articles that were reviewed for relevancy, of which 27 were deemed to have met the inclusion criteria for this assessment. Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.07.031DOI Listing

Localized Sebaceous Carcinoma Treatment: Wide Local Excision verses Mohs Micrographic Surgery.

Dermatol Ther 2020 Jul 9:e13991. Epub 2020 Jul 9.

Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Background: The optimal surgical management of sebaceous carcinoma (SC) has yet to be determined between Mohs micrographic surgery (MMS) and wide local excision (WLE).

Objective: To investigate overall survival (OS) differences for SC undergoing WLE or MMS METHODS: The National Cancer Database (NCDB) was queried for all SC from 2004 to 2015 (n = 2863). Cases missing staging data, undergoing palliative care, showing lymph node extension, or of AJCC Stage III/IV were omitted. Read More

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http://dx.doi.org/10.1111/dth.13991DOI Listing

Clinical features and prognosis of sebaceous carcinoma arising in the eyelid or conjunctiva.

Jpn J Ophthalmol 2020 Jul 8. Epub 2020 Jul 8.

Department of Plastic Surgery, Tokyo Medical University, Tokyo, Japan.

Purpose: The aim of this study was to clarify the demographics, clinical features, and outcomes of Japanese patients with sebaceous carcinoma of the eyelid or conjunctiva.

Study Design: Retrospective study.

Methods: One hundred twenty-five patients with sebaceous carcinoma of the eyelid or conjunctiva diagnosed at Tokyo Medical University Hospital between 1994 and 2017 were reviewed. Read More

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http://dx.doi.org/10.1007/s10384-020-00756-xDOI Listing

Epidemiology of cutaneous sebaceous carcinoma.

Australas J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

South Australian Institute of Ophthalmology, Royal Adelaide Hospital, The University of Adelaide, Adelaide, Australia.

There has been uncertainty about the demographics and anatomical distribution of cutaneous sebaceous carcinoma. This study aims to investigate these uncertainties by analysing data from various countries. Data were obtained from cancer registries of the United States, England, Norway and Taiwan, and incidence rates were calculated with uniform age-adjustment. Read More

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http://dx.doi.org/10.1111/ajd.13387DOI Listing

Special type breast carcinoma: Sebaceous carcinoma of the breast; A case report and review of literature.

Breast J 2020 Jul 4. Epub 2020 Jul 4.

General Surgery Department, Saint George Hospital University Medical Center, University of Balamand, Beirut, Lebanon.

Sebaceous carcinoma of the breast is an extremely rare tumor. To the best of our knowledge only 15 cases have been reported in literature. Herein, we report a case of sebaceous carcinoma of the breast and describe the histopathologic features of sebaceous carcinoma of the breast in an elderly female. Read More

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http://dx.doi.org/10.1111/tbj.13963DOI Listing

Mohs micrographic surgery: a treatment method for many non-melanocytic skin cancers.

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

Department of Dermatology, Baylor College of Medicine, Houston, TX.

Mohs micrographic surgery (MMS) is a breakthrough surgical technique that has changed the management of neoplasms in dermatology. Through continued practice and evolution, MMS now can successfully treat a variety of rare non-melanocytic cutaneous malignancies for which achieving remission and the optimal aesthetic result after surgery was previously challenging. Mohs micrographic surgery has utility for conditions besides melanoma. Read More

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Sebaceous Carcinoma of the Breast: Fact or Fiction? A Case Report and a Review of the Literature.

Int J Surg Pathol 2020 Jul 1:1066896920937784. Epub 2020 Jul 1.

Macerata General Hospital, Macerata, Italy.

Previously considered an exceedingly rare entity, sebaceous carcinoma of the breast is now regarded in the World Health Organization 2019 classification as a "special histopathological pattern" of invasive breast carcinoma of no special type. . In this article, we report the case of a fine needle aspiration cytology and the histopathological features of a breast carcinoma with clear-cut morphological features suggesting sebaceous differentiation, but showing no positive staining with the anti-adipophilin antibody. Read More

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http://dx.doi.org/10.1177/1066896920937784DOI Listing

Periocular skin cancer: Diagnosis and management.

Dis Mon 2020 Jun 26:101046. Epub 2020 Jun 26.

Division of Ophthalmology, NorthShore University Health System, 2050 Pfingsten Rd., Ste. 280, Glenview, IL 60026, United States; Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, United States. Electronic address:

The periocular region sees high rates of cancer compared to the rest of the body and can be affected by several unique tumors. Treatment typically involves surgical excision, although adjunctive therapies and prognosis vary depending on the diagnosis. Basal cell carcinoma (BCC) is the most common malignancy affecting this region and should be excised promptly. Read More

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http://dx.doi.org/10.1016/j.disamonth.2020.101046DOI Listing
June 2020
0.535 Impact Factor

Sebaceous Carcinoma In Situ of the External Auditory Canal.

Otol Neurotol 2020 Jul;41(6):e765-e766

Department of ENT Surgery, Al Hussein Salt Hospital, Ministry of Health, Al-Salt, Jordan.

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http://dx.doi.org/10.1097/MAO.0000000000002687DOI Listing
July 2020
1.598 Impact Factor

Metastatic Prostatic Adenocarcinoma in Patient With Muir-Torre Syndrome Misdiagnosed as Metastatic Sebaceous Carcinoma: Case Report and Systematic Literature Review.

Am J Dermatopathol 2020 Jun 5. Epub 2020 Jun 5.

Department of Pathology, McGill University Health Centre, Montreal, Québec, Canada.

Muir-Torre syndrome (MTS) is a rare autosomal dominant condition characterized by the presence of at least one cutaneous sebaceous tumor and one visceral malignancy, arising mostly from the gastrointestinal tract. We present the case of a 63-year-old man with several cutaneous and visceral neoplasias in the context of MTS, and a pelvic lymph node lesion diagnosed initially as metastatic sebaceous carcinoma, but later identified as metastasis from a newly diagnosed prostatic adenocarcinoma. Histological similarities between these 2 lesions are discussed. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001633DOI Listing
June 2020
1.426 Impact Factor

An Unusual Histopathological Presentation of Epidermotropic Metastatic Pharyngeal Squamous Cell Carcinoma.

Am J Dermatopathol 2020 Jun 5. Epub 2020 Jun 5.

Departments of Pathology, and.

Epidermotropic metastasis of head and neck squamous cell carcinoma is rare. We report a case of a 56-year-old white man with a history of oral squamous cell carcinoma who presented with multiple papules on the face, eyelid, and chest wall. The histopathologic examination of the skin lesions revealed nests of malignant cells with basaloid features and zones of cytoplasmic vacuolization predominantly within the dermis but focally involving the epidermis. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001688DOI Listing

Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors.

Am J Dermatopathol 2020 Jun 15. Epub 2020 Jun 15.

Gerhard-Domagk-Institute of Pathology, University of Muenster, Münster, Germany.

Extraocular sebaceous carcinoma (ESC) is a rare appendiceal skin tumor. In contrast to ocular sebaceous carcinoma, information about the exact cellular architecture of these lesions is scarce and the histogenesis of ESC is unknown. Here, we extend our previous study and investigate 28 extraocular carcinomas in comparison to 54 benign sebaceous tumors and 8 cases of normal sebaceous glands using a broad spectrum of antibodies against p63, several keratins, adipophilin, EMA, Ki67, androgen receptor, and mismatch repair proteins. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001667DOI Listing

Eyelid sebaceous gland carcinoma: An assessment of the T classification of the American Joint Committee of Cancer TNM staging system 8th versus 7th edition.

Eur J Ophthalmol 2020 Jun 21:1120672120936488. Epub 2020 Jun 21.

King Khaled Eye Specialist Hospital- KKESH- Riyadh, Saudi Arabia.

Purpose: To assess the prognostic values of the T classification of the 8th edition of the American Joint Committee of Cancer staging system and compare it to the 7th edition.

Methods: Multicenter retrospective study of patients with eyelid sebaceous gland carcinoma. The primary outcome measure was the differences between outcomes when tumors were staged with either 7th or 8th edition. Read More

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http://dx.doi.org/10.1177/1120672120936488DOI Listing

Reflectance confocal microscopy. Part II. Diagnostic criteria of common benign and malignant neoplasms, dermoscopic and histopathological correlates of key confocal criteria, and diagnostic algorithms.

J Am Acad Dermatol 2020 Jun 18. Epub 2020 Jun 18.

The Kittner Skin Cancer Screening and Research Institute, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Dermatology Service, Memorial Sloan-Kettering Center, New York, NY.

Reflectance confocal microscopy (RCM) is a high-resolution, non-invasive tool currently FDA-approved for obtaining and interpreting images of the skin and cutaneous neoplasms with the goal of decreasing biopsy of benign lesions. Part II of this continuing medical education series focuses on identifying key criteria for the diagnosis of common skin cancers-melanoma, basal cell carcinoma, and squamous cell carcinoma. We contrast these findings with RCM features of common benign lesions-melanocytic nevi, solar lentigo, seborrheic keratosis, lichen planus-like keratosis, and sebaceous hyperplasia. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.154DOI Listing

Clinicopathological correlation of malignant skin tumors: A retrospective study of 5 years.

Int J Health Sci (Qassim) 2020 May-Jun;14(3):18-25

Department of Pathology, Government Medical College, Miraj, Maharashtra, India.

Objective: Skin cancers are relatively uncommon malignancies worldwide, but there is a progressive increase in the incidence over the last few decades.

Methods: We have studied the clinical and histopathological features of malignant skin tumors received in the department of pathology of our tertiary care institute over a period of 3 years and 8 months. A detailed analysis of clinical, gross, and microscopic findings was performed, followed by clinicopathological correlation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269623PMC

Sebaceous carcinoma of the nose: For a difficult diagnosis, a challenging reconstruction.

Dermatol Ther 2020 Jun 14:e13841. Epub 2020 Jun 14.

Department of Dermatovenereology, Coimbra University Hospital, Coimbra, Portugal.

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http://dx.doi.org/10.1111/dth.13841DOI Listing

Four pediatric cases of secondary neoplasms arising in nevus sebaceous.

Dermatol Ther 2020 Jun 3:e13762. Epub 2020 Jun 3.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center For Children's Health, Beijing, China.

Secondary neoplasms of epidermal adnexal origin have been reported to develop into nevus sebaceous (NS), mainly in adulthood but rarely in children. Four cases of secondary neoplasms were identified in 413 children of nevus sebaceous from 2015 to 2019 by our department, accounting for 1% of all cases. We here report the clinical, dermoscopical, and histopathological features of these tumors, including syringocystadenoma papilliferum (SCAP), pilomatricoma, trichilemmoma, and basal cell carcinoma (BCC). Read More

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http://dx.doi.org/10.1111/dth.13762DOI Listing

Nationwide Trends in the Incidence and Survival of Eyelid Skin Cancers in Korea.

Ophthalmic Epidemiol 2020 Jun 2:1-11. Epub 2020 Jun 2.

Division of Cancer Registration and Surveillance, National Cancer Center , Goyang, Republic of Korea.

Purpose: This study provides a population-based report on eyelid skin cancer epidemiology showing trends in its incidence and survival in South Korea.

Methods: For this population-based epidemiological study, nationwide cancer incidence data were obtained from the Korea Central Cancer Registry, covering the entire population. Age-standardised incidence rates (ASRs) and annual per cent changes (APCs) were calculated according to sex, histological types, stage, and date of diagnosis. Read More

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http://dx.doi.org/10.1080/09286586.2020.1767152DOI Listing

Risk of rare cancers among solid organ transplant recipients.

J Natl Cancer Inst 2020 May 27. Epub 2020 May 27.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

Background: Immunosuppressed solid organ transplant recipients [SOTRs] have elevated rates of certain rare cancers caused by viruses. Evaluating risk of rare cancers among SOTRs may provide etiological clues for additional cancers linked to poor immunity and viral infections.

Methods: We performed a cohort study of 262,455 SOTRs (1987-2014) from the US SOTR registry linked to 17 population-based cancer registries. Read More

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http://dx.doi.org/10.1093/jnci/djaa078DOI Listing

Dermoscopic features and differential diagnosis of sebaceous carcinoma.

J Dermatol 2020 Jul 16;47(7):755-762. Epub 2020 May 16.

Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan.

Sebaceous carcinoma is a rare malignant skin neoplasm arising from sebaceous glands. Its clinical diagnosis is difficult and reports of dermoscopic findings have been limited. This study aims to analyze its dermoscopic features and differential diagnosis in dermoscopic examination. Read More

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http://dx.doi.org/10.1111/1346-8138.15384DOI Listing

Sebaceous carcinoma and basal cell carcinoma arising within nevus sebaceous on the face-A rare entity with dermatoscopic findings.

Dermatol Ther 2020 May 13:e13576. Epub 2020 May 13.

Department of Dermatology, Ankara University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1111/dth.13576DOI Listing

Epithelial sheath neuroma: A case report and literature review.

Clin Neuropathol 2020 May 8. Epub 2020 May 8.

In this paper we report a case of the rare entity epithelial sheath neuroma (ESN). A 66-year-old white female presented with a 1-month history of pruritic, raised, erythematous skin lesion on her upper back. The clinical impression initially led to a differential diagnosis that included lymphoma or inflamed sebaceous cyst. Read More

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http://dx.doi.org/10.5414/NP301251DOI Listing

Rapid Rehabilitation With Skin-Muscle Sparing Orbital Exenteration: A Single-Center Series.

Ophthalmic Plast Reconstr Surg 2020 May 4. Epub 2020 May 4.

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Aims: To examine the features and clinical management of patients who underwent skin-muscle sparing orbital exenteration in a tertiary referral center.

Patients And Method: Retrospective case-note review for patients undergoing skin-muscle sparing orbital exenteration at Moorfields Eye Hospital between 1997 and 2012. Patient demographics, clinical features, histopathology, clearance, surgery, adjuvant therapy, and outcomes were analyzed. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001677DOI Listing

Misdiagnosis of sebaceous carcinoma.

Acta Chir Belg 2020 May 19:1-6. Epub 2020 May 19.

Department of Plastic Surgery, ZNA Middelheim Hospital, Antwerp, Belgium.

Sebaceous carcinoma is an aggressive malignant tumour. To prevent mutilating surgery and improve patient outcomes, early diagnosis and prompt treatment are necessary. When the tumour invades surrounding tissues, treatment may become complex. Read More

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http://dx.doi.org/10.1080/00015458.2020.1765674DOI Listing

Ocular Sebaceous Carcinoma In Situ With Biphenotypic Differentiation: A Reappraisal of the Alternative Origin of the Tumor.

Int J Surg Pathol 2020 May 4:1066896920917445. Epub 2020 May 4.

Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China.

Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with no invasive carcinoma in the underlying sebaceous glands. Early stromal invasion was identified that featured 2 distinctive but focally intermixed populations of sebaceous carcinoma cells and squamous carcinoma cells. Read More

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http://dx.doi.org/10.1177/1066896920917445DOI Listing

Detection of Epstein-Barr Virus in 130 Cases of Eyelid Sebaceous Gland Carcinoma Using In Situ Hybridization.

J Ophthalmol 2020 30;2020:7354275. Epub 2020 Mar 30.

Department of Ocular Pathology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China.

Purpose: In this study, we aimed to investigate the presence of Epstein-Barr virus (EBV) in the eyelid sebaceous gland carcinoma (SGC) and its association with the clinicopathologic features.

Methods: One hundred and thirty paraffin-embedded SGC specimens were retrieved from the Clinical Pathology Department of Zhongshan Ophthalmic Center. Epstein-Barr virus-encoded RNA (EBER) was detected with in situ hybridization (ISH) using the Leica BOND system autostainer. Read More

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http://dx.doi.org/10.1155/2020/7354275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152957PMC

Bowen disease with matrical differentiation: Report of an exceptional histopathologic presentation.

J Cutan Pathol 2020 Apr 16. Epub 2020 Apr 16.

Dermatopathology Bodensee, Friedrichshafen, Germany.

Matrical differentiation is the distinctive feature of pilomatricoma and other purely matrical adnexal neoplasms; additionally, foci of matrical differentiation have been also described in hybrid cysts of Gardner syndrome, as well as in a wide variety of benign and malignant cutaneous tumors, including basal cell carcinoma. We report an exceptional case of Bowen disease exhibiting multiple foci of matrical differentiation, as confirmed by means of immunohistochemical studies. Several types of divergent, non-squamous differentiation have been exceptionally reported in cutaneous squamous cell carcinoma in situ (cSCCIS), including sebaceous, mucinous/glandular, poroid, tricholemmal, and neuroendocrine differentiation; matrical differentiation may be added to this list. Read More

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http://dx.doi.org/10.1111/cup.13714DOI Listing

Are clinicians successful in diagnosing cutaneous adnexal tumors? a retrospective, clinicopathological study.

Turk J Med Sci 2020 Apr 14. Epub 2020 Apr 14.

Background And Aim: Cutaneous adnexal tumors (CAT) are rare tumors originating from the adnexal epithelial parts of the skin. Due to its clinical and histopathological characteristics comparable with other diseases, clinicians and pathologists experience difficulties in its diagnosis. We aimed to reveal the clinical and histopathological characteristics of the retrospectively screened cases and to compare the pre-diagnoses and histopathological diagnoses of clinicians. Read More

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http://dx.doi.org/10.3906/sag-2002-126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379409PMC

Prognostic significance of immune checkpoints in the tumour-stromal microenvironment of sebaceous gland carcinoma.

Br J Ophthalmol 2020 Apr 10. Epub 2020 Apr 10.

Ocular Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India

Background: Immune checkpoint blockade strategies have gained attention in the treatment/prognosis of cancers by targeting the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway alone or in combination with cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) blockade and are currently in clinical trials. The present study investigated the expression of the PD-1, PD-L1, CTLA-4, CD4 and CD8 proteins and their prognostic value in the tumour microenvironment of sebaceous gland carcinoma (SGC).

Methods: The expression levels of PD-1, PD-L1, CTLA-4, CD4 and CD8 proteins were assessed in 52 cases of SGC by immunohistochemistry and validated by western blotting. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315490DOI Listing
April 2020
2.976 Impact Factor

Pigmented sebaceous carcinoma: dermatoscopic features of a new case.

Eur J Dermatol 2020 Feb;30(1):58-60

Department of dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1684/ejd.2019.3688DOI Listing
February 2020

Comprehensive germline mutation analysis and clinical profile in a large cohort of Brazilian xeroderma pigmentosum patients.

J Eur Acad Dermatol Venereol 2020 Apr 1. Epub 2020 Apr 1.

Centro de Oncologia, Hospital Sírio-Libanês, São Paulo, São Paulo, Brazil.

Background: Xeroderma pigmentosum (XP) patients present a high risk of developing skin cancer and other complications at an early age. This disease is characterized by mutations in the genes related to the DNA repair system.

Objectives: To describe the clinical and molecular findings in a cohort of 32 Brazilian individuals who received a clinical diagnosis of XP. Read More

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http://dx.doi.org/10.1111/jdv.16405DOI Listing

Extraocular Sebaceous Carcinoma Presenting As a Nodule over the Zygoma.

Cureus 2020 Feb 3;12(2):e6858. Epub 2020 Feb 3.

Pathology, University of Arkansas for Medical Sciences, Little Rock, USA.

We describe a case of sebaceous carcinoma (SC) in a 75-year-old man who presented with a rapidly growing nodule on the left cheek for four weeks. A 75-year-old man presented with a crusted non-tender nodule on the left cheek that had been present for six months. The nodule showed rapid growth in the four weeks before the visit. Read More

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http://dx.doi.org/10.7759/cureus.6858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053665PMC
February 2020

Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma.

BMC Ophthalmol 2020 Mar 16;20(1):103. Epub 2020 Mar 16.

Department of Ophthalmology, Helsinki University Hospital and University of Helsinki, PO Box 220, FI-00029 HUS, Helsinki, Finland.

Background: The purpose was to describe the Nordic treatment practices and to reach a Nordic consensus for the treatment of sebaceous eyelid carcinoma.

Methods: The treatment practices data was collected by a questionnaire with 37 questions to the Nordic oculoplastic surgeons and analyzed. A PubMed MEDLINE database search was done to gather data on the published treatment practices and recommendations. Read More

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http://dx.doi.org/10.1186/s12886-020-01367-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074984PMC

PIWIL-2 and piRNAs are regularly expressed in epithelia of the skin and their expression is related to differentiation.

Arch Dermatol Res 2020 Mar 12. Epub 2020 Mar 12.

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

PIWI proteins play multiple roles in germline stem cell maintenance and self-renewal. PIWI-interacting RNAs (piRNAs) associate with PIWI proteins, form effector complexes and maintain genome integrity and function in the regulation of gene expression by epigenetic modifications. Both are involved in cancer development. Read More

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http://dx.doi.org/10.1007/s00403-020-02052-7DOI Listing

Lacrimal Canalicular Reconstruction With Canalicular Transposition.

J Craniofac Surg 2020 May/Jun;31(3):e283-e285

Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Korea.

Medial eyelid defects often damage the lacrimal drainage system, and reconstruction for these patients is challenging. The purpose of this report is to describe a new surgical technique for canalicular reconstruction using canalicular transposition. A 67-year-old female patient presented with an eyelid tumor diagnosed as a sebaceous cell carcinoma at the medial left lower eyelid. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006272DOI Listing

Sebaceous carcinoma of the breast predominantly characterized by intraductal growth: a case report.

Surg Case Rep 2020 Feb 24;6(1):41. Epub 2020 Feb 24.

Koyama Clinic, 1-2557-1, Jonan, Suwa, Nagano, 392-0017, Japan.

Background: Sebaceous carcinoma (SC) is frequently classified as periocular or extraocular. Extraocular SC is rare and mainly occurs in the head and neck, the major salivary glands, or oral mucosa. SC of the breast, lung, and ovary is particularly rare, and the few cases of SC of the breast predominantly exhibit intraductal growth. Read More

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http://dx.doi.org/10.1186/s40792-020-0799-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040145PMC
February 2020

Concomitant Orbital Tumours: Small Lymphocytic Lymphoma Involving the Lacrimal Gland of a Patient with Clinical Diagnoses of Muir-Torre Syndrome and Extensive Sebaceous Gland Carcinoma of the Ipsilateral Eyelid.

Ocul Oncol Pathol 2020 Jan 5;6(1):15-19. Epub 2019 Jun 5.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom.

Background/aims: We present a case of 2 concomitant tumours, i.e., a sebaceous carcinoma (SC) and a small lymphocytic lymphoma (SLL), in the lacrimal gland of a patient with Muir-Torre syndrome

Methods: Clinical history, orbital examination, diagnostic biopsy, excisional biopsy, and histopathologic analysis were utilized. Read More

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http://dx.doi.org/10.1159/000500161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984142PMC
January 2020

Malignant Transformation of Parotid Gland Non-sebaceous Lymphadenoma: Case Report and Review of Literature.

Head Neck Pathol 2020 Jan 29. Epub 2020 Jan 29.

Department of Otolaryngology & Head and Neck Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Non-sebaceous lymphadenoma is a sporadic benign tumor of salivary glands. Histopathologic and immunohistochemical properties, diagnostic criteria, and theories for the histologic origin of the disease have been defined and well-discussed in the literature. However, none of the cases showed malignant transformation to date. Read More

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http://dx.doi.org/10.1007/s12105-020-01133-3DOI Listing
January 2020

Detection of DNA mismatch repair deficient crypts in random colonoscopic biopsies identifies Lynch syndrome patients.

Fam Cancer 2020 04;19(2):169-175

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

The hallmark of Lynch syndrome (LS)-associated neoplasia is DNA mismatch repair protein (MMR) deficiency. Recent studies have demonstrated that histologically normal colonic crypts in patients with LS can exhibit deficient MMR expression. The aim of this study was to determine the feasibility of detecting MMR deficient crypts in random colonoscopic biopsies of normal mucosa in patients with and without LS. Read More

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http://dx.doi.org/10.1007/s10689-020-00161-wDOI Listing

Desmoplastic Trichoepithelioma: An Uncommon but Diagnostically Problematic Benign Adnexal Tumor.

Acta Dermatovenerol Croat 2019 Dec;27(4):282-284

Vladimír Bartoš, MD, PhD, MPH, Deapartment of Pathology Faculty Hospital in Žilina, Vojtecha Spanyola 43, 012 07 Žilina, Slovakia;

Dear Editor, I read an interesting recent article by Karimzadeh et al. (1) in an earlier issue of your journal, who provided a comprehensive review addressing a relatively rare benign tumor originating from the hair follicles - trichoepithelioma (TE). They rightly claimed that trichoepithelioma can be divided into the following 3 subgroups: a) multiple familiar TE, b) solitary non-hereditary TE, and c) desmoplastic trichoepithelioma (DTE). Read More

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December 2019

Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.

Diagn Cytopathol 2020 May 22;48(5):424-429. Epub 2020 Jan 22.

Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri.

Background: Sebaceous lymphadenomas and sebaceous lymphadenocarcinomas are uncommon neoplasms occurring predominately within the parotid gland. Cytomorphology of these neoplasms is rarely reported. Occasional reports have discussed the cytomorphological features of these neoplasms but criteria distinguishing sebaceous lymphadenomas from lymphadenocarcinomas have not been described. Read More

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http://dx.doi.org/10.1002/dc.24357DOI Listing

Orbital exenteration and conjunctival melanoma: a 14-year study at the Jules Gonin Eye Hospital.

Eye (Lond) 2020 Jan 20. Epub 2020 Jan 20.

Ophthalmology Department, Jules Gonin Eye Hospital, Lausanne, Switzerland.

Purpose: To report our 14-year experience with orbital exenteration and assess risk factors for poor prognosis by focusing on conjunctival melanoma.

Patients And Method: A retrospective study was conducted in our tertiary care centre (Jules Gonin Eye Hospital, Lausanne, Switzerland) between 2003 and 2017. Inclusion criteria were patients aged  ≥18 years with a follow-up >12 months, without metastatic spread at the time of surgery. Read More

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http://dx.doi.org/10.1038/s41433-020-0767-6DOI Listing
January 2020

Cutaneous sebaceous carcinoma.

Australas J Dermatol 2020 Jan 19. Epub 2020 Jan 19.

Adelaide Skin and Eye Centre, Adelaide, South Australia, Australia.

Cutaneous sebaceous carcinoma occurs almost exclusively on the head and neck and has a significant propensity for recurrence and metastasis. It is easily mistaken for benign conditions, resulting in inappropriate management. Thus, it is important to maintain a high index of suspicion. Read More

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http://dx.doi.org/10.1111/ajd.13234DOI Listing
January 2020

Whole-exome sequencing for ocular adnexal sebaceous carcinoma suggests PCDH15 as a novel mutation associated with metastasis.

Mod Pathol 2020 Jul 14;33(7):1256-1263. Epub 2020 Jan 14.

Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1488, Houston, TX, 77030, USA.

Ocular adnexal sebaceous carcinoma (OASeC) is an aggressive eyelid carcinoma. Analysis of molecular-genetic drivers of this disease could reveal new prognostic markers and actionable targets for treatment. To identify somatically acquired genomic mutations in OASeC and explore their associations with metastasis, whole-exome sequencing on DNA extracted from retrospectively collected tumor samples was performed. Read More

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http://dx.doi.org/10.1038/s41379-020-0454-yDOI Listing