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    1 OF 38

    Malignant tumors associated with ovarian mature teratoma: A single institution experience.
    Pathol Res Pract 2017 Jan 22. Epub 2017 Jan 22.
    Department of Gynecology and Obstetrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
    Objective: The aims of this study are to present demographical features of cases diagnosed with malignant tumor associated with ovarian mature teratoma and to analyze histopathological features and clinical follow up of these tumors.

    Study Design: Single-institution retrospective charts were reviewed to identify all cases of ovarian mature teratoma diagnosed from 1998 to 2015. Clinicopathological parameters that were analyzed include age, tumor size, tumor stage, histological type, laterality, IOC diagnosis and whether or not patient has received adjuvant chemotherapy. Read More

    Reconstructive Surgery of the Upper Eyelid Using the Residual Tarsus after Excision of Sebaceous Gland Carcinoma.
    Case Rep Ophthalmol 2016 Sep-Dec;7(3):308-314. Epub 2016 Dec 28.
    Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
    Purpose: To report a successful eyelid reconstruction performed using the residual tarsus after excision of a sebaceous gland carcinoma.

    Case Report: An 86-year-old woman presented with a sebaceous gland carcinoma of the upper eyelid margin. After excision of the tumor, she underwent reconstructive surgery of the superior eyelid performed using the residual tarsus. Read More

    Sebaceous carcinoma in solid organ transplant recipients.
    Int J Dermatol 2017 Feb 8. Epub 2017 Feb 8.
    Mayo Clinic Arizona, Scottsdale, AZ, USA.
    Background: Though a rare tumor, sebaceous carcinoma is relatively well-described in immunocompetent patients, in whom it often occurs in a periorbital distribution where it has an overall poor prognosis with a high metastasis rate. The effect of transplant-related immunosuppression on the development of sebaceous carcinoma and its outcomes has not been characterized.

    Methods: We collected 9 cases from a single institution of patients developing sebaceous carcinoma after solid organ transplantation. Read More

    Sebaceous Carcinoma Treated With Mohs Micrographic Surgery.
    Dermatol Surg 2017 Feb;43(2):281-286
    *Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York;†Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri.
    Background: Sebaceous carcinoma is a rare and potentially aggressive adnexal neoplasm with historic data indicating high rates of recurrence, metastasis, and cancer-specific mortality.

    Objective: To evaluate the incidence of local recurrence, metastasis, disease-specific mortality, and all-cause mortality and to identify work-up approaches.

    Patients And Methods/materials: Retrospective review of patients with sebaceous carcinoma treated with Mohs micrographic surgery between 2001 and 2013 at one institution. Read More

    Outcome of Flap Surgeries in Dermatosurgical Unit at a Tertiary Care Centre in India with a Review of Literature.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):226-231
    Department of Dermatology, Bangalore Medical College and Research Institute, Victoria Hospital, Bengaluru, Karnataka, India.
    Introduction: Flap surgeries are an excellent choice for closing large defects following trauma, excision of carcinomas or removal of large lesions. This article is a prospective interventional study of various flap surgeries performed at a tertiary care centre with their outcome in dermatosurgical unit.

    Materials And Methods: A total of 35 flap surgeries performed from January 2012 to December 2014 formed part of the study. Read More

    Muir-Torre syndrome caused by exonic deletion of MLH1 due to homologous recombination.
    Eur J Dermatol 2017 Feb;27(1):54-58
    Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
    Background: Muir-Torre syndrome (MTS) is characterized by sebaceous neoplasms with internal malignancies and regarded as a variant of hereditary nonpolyposis colorectal cancer (HNPCC). Pathogenic variations of MTS have been identified in the MSH2, MLH1, and MSH6 genes, with the majority of variations located in MSH2.

    Objectives: To present an MTS patient who was the only individual with skin malignancies within a cancer-prone pedigree and to show the usefulness of RNA-based genetic analysis in the investigation of MTS. Read More

    miRNA-200c and miRNA-141 as potential prognostic biomarkers and regulators of epithelial-mesenchymal transition in eyelid sebaceous gland carcinoma.
    Br J Ophthalmol 2017 Jan 24. Epub 2017 Jan 24.
    Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
    Background: MicroRNA (miRNA)-200c and miRNA-141 are tumour suppressors, which regulate epithelial-mesenchymal transition (EMT), leading to tumour invasion and metastasis in various malignancies. miRNA-200c and miRNA-141 maintain the epithelial phenotype by post-transcriptionally inhibiting the E-cadherin repressors, zinc finger E-box binding homeobox (ZEB)1 and ZEB2. The present study was performed to determine the prognostic significance of miRNA-200c and miRNA-141, and their association with EMT markers ZEB1, ZEB2 and E-cadherin in eyelid sebaceous gland carcinoma (SGC). Read More

    MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors.
    J Cutan Pathol 2017 Jan 18. Epub 2017 Jan 18.
    Departments of Dermatology and Pathology, University of California, San Francisco, California.
    Background: Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors. Read More

    High Resolution Diffusion-Weighted Imaging for Solitary Orbital Tumors : 3D Turbo Field Echo with Diffusion-Sensitized Driven-Equilibrium (DSDE-TFE) Preparation Technique.
    Clin Neuroradiol 2017 Jan 17. Epub 2017 Jan 17.
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan.
    Purpose: To differentiate cystic from solid solitary intraorbital tumors using 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation without contrast material.

    Materials And Methods: This retrospective study was approved by our institutional review boards, and written informed consent was waived. A total of 26 patients with intraorbital tumors were studied. Read More

    Distinct expression profile of stem cell markers, LGR5 and LGR6, in basaloid skin tumors.
    Virchows Arch 2017 Jan 9. Epub 2017 Jan 9.
    Department of Pathology, Seoul National University College of Medicine, 28 Yeongeon-dong, Seoul, 110-799, South Korea.
    Mammalian epidermis, which is composed of hair follicles, sebaceous glands, and interfollicular epidermis, is maintained by discrete stem cells. In vivo lineage tracing demonstrated that murine LGR5 cells are mainly responsible for hair follicle regeneration whereas LGR6 cells generate sebaceous glands and interfollicular epidermis. However, little is known about their expression in the human skin tumors. Read More

    Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer.
    Plast Reconstr Surg 2017 Jan;139(1):181e-190e
    New York, N.Y. From the Dermatology Service and the Plastic Surgery Service, Memorial Sloan Kettering Cancer Center.
    Learning Objectives: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Read More

    Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.
    Dermatol Surg 2017 Jan;43(1):116-124
    *Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.
    Background: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data.

    Objective: To determine the incidence of several rare nonmelanoma skin cancers. Read More

    Identification of MSH2 inversion of exons 1-7 in clinical evaluation of families with suspected Lynch syndrome.
    Fam Cancer 2016 Dec 21. Epub 2016 Dec 21.
    Clinical Cancer Genetics Program, UT MD Anderson Center, Unit 1354, 1155 Pressler St., Houston, TX, 77030, USA.
    Traditional germline sequencing and deletion/duplication analysis does not detect Lynch syndrome-causing mutations in all individuals whose colorectal or endometrial tumors demonstrate mismatch repair (MMR) deficiency. Unique inversions and other rearrangements of the MMR genes have been reported in families with Lynch syndrome. In 2014, a recurrent inversion of MSH2 exons 1-7 was identified in five families suspected to have Lynch syndrome. Read More

    Mohs micrographic surgery of rare cutaneous tumours.
    J Eur Acad Dermatol Venereol 2016 Dec 15. Epub 2016 Dec 15.
    Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
    Background: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined.

    Objective: To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre.

    Methods & Materials: Retrospective review of all rare cutaneous tumours treated with MMS at a large university centre between January 2008 and December 2012. Read More

    [Therapy options for malignant eyelid tumors].
    Ophthalmologe 2016 Dec;113(12):1095-1108
    Augenklinik mit Poliklinik der Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland.
    Basal cell carcinomas are the most common malignant tumors of the eyelids. Patient history, clinical symptoms and signs, inspection, palpation and slit-lamp examination usually allow a working diagnosis; however, the clinical diagnosis requires histopathological confirmation and determination of the histopathological type. Squamous cell carcinomas, sebaceous gland carcinomas, melanomas and Merkel cell carcinomas can metastasize usually via the lymph vessels into the regional lymph nodes. Read More

    Cutaneous Sebaceous Lesions in a Patient With MUTYH-Associated Polyposis Mimicking Muir-Torre Syndrome.
    Am J Dermatopathol 2016 Dec;38(12):915-923
    *Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Prague, Czech Republic; †Bioptical Laboratory, Pilsen, Czech Republic; and ‡Department of Dermatology, Regional Hospital, Sumperk, Czech Republic.
    A 76-year-old white male with a history of adenocarcinoma of the rectosigmoideum and multiple colonic polyps removed at the age of 38 and 39 years by an abdominoperitoneal amputation and total colectomy, respectively, presented with multiple whitish and yellowish papules on the face and a verrucous lesion on the trunk. The lesions were surgically removed during the next 3 years and a total of 13 lesions were investigated histologically. The diagnoses included 11 sebaceous adenomas, 1 low-grade sebaceous carcinoma, and 1 squamous cell carcinoma. Read More

    Sebaceous carcinoma of the vulva: A case report and review of the literature.
    Gynecol Oncol Rep 2016 Nov 29;18:40-41. Epub 2016 Oct 29.
    University of North Carolina at Chapel Hill, Gynecologic Oncology, United States; University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, United States.
    •Sebaceous carcinoma (SC) is rare with only nine cases reported in the literature.•Extraocular SC likely has similar prognosis to ocular SC.•Reporting of vulvar SC should include detailed pathologic information so that risk factor associations can be made. Read More

    Unusual Presentation of Ulcerative Postauricular Swelling as Sebaceous Cell Carcinoma.
    Niger J Surg 2016 Jul-Dec;22(2):127-129
    Department of General Surgery, Government Medical College, Patiala, Punjab, India.
    Sebaceous glands have high concentration over head and neck region. Despite high concentration, sebaceous cell adenoma and carcinomas are infrequent. Sebaceous cell carcinoma is an uncommon, cutaneous aggressive tumor arising from the sebaceous glands and seen almost exclusively on the eyelids (75%). Read More

    Histopathologic pitfalls of Mohs micrographic surgery and a review of tumor histology.
    Wien Med Wochenschr 2016 Nov 10. Epub 2016 Nov 10.
    Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Università Degli Studi "G. Marconi", Rome, Italy.
    Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Read More

    Generational Expression of Muir-Torre Syndrome in a Canadian Family.
    Case Rep Dermatol Med 2016 16;2016:1712527. Epub 2016 Oct 16.
    Department of Biomolecular Sciences, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON, Canada.
    Muir-Torre syndrome (MTS) is a rare autosomal dominant inherited genodermatosis that is considered to be a phenotypic subtype of hereditary nonpolyposis colorectal cancer (HNPCC), commonly referred to as Lynch syndrome. We describe the clinical course of a 57-year-old female patient with MTS. She has a confirmed HMSH2 mutation. Read More

    Cutaneous Horn of the Eyelid in 13 Cases.
    Ophthal Plast Reconstr Surg 2016 Nov 2. Epub 2016 Nov 2.
    *Ocular Oncology Service and †Department of Ophthalmic Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
    Introduction: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid.

    Objective: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. Read More

    [Muir-Torre syndrome associated with Waldenstrom's macroglobulinemia].
    Ann Dermatol Venereol 2016 Dec 19;143(12):825-830. Epub 2016 Oct 19.
    Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67000 Strasbourg, France.
    Background: Muir-Torre syndrome (MTS), a cutaneous variant of Lynch syndrome, consists of hereditary predisposition to cutaneous tumours and gastrointestinal and gynaecological neoplasms, with autosomal dominant transmission. It is associated with mutations in genes coding for proteins in the DNA mismatch repair system.

    Patients And Methods: Herein, we report a case of a male patient presenting Waldenstrom's macroglobulinemia since the age of 50 and which, after the age of 65 years, developed into sebaceous tumours (5 sebaceous adenomas, 1 sebaceoma, 1 sebaceous carcinoma) and colonic lesions (4 adenomas). Read More

    Orbital exenteration for advanced periorbital non-melanoma skin cancer: prognostic factors and survival.
    Eye (Lond) 2016 Oct 21. Epub 2016 Oct 21.
    Department of Ophthalmology, Division of Oculoplastic Surgery, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
    PurposeTo describe prognostic factors and survival outcomes in patients who underwent orbital exenteration for periocular non-melanoma cutaneous malignancies.MethodsThe authors performed an institutional review board-approved retrospective review of all patients who underwent orbital exenteration for non-melanoma periocular cutaneous malignancies at a tertiary care hospital system over a 10-year period. Patient demographics, tumor, and treatment data were recorded. Read More

    Extraocular Sebaceous Carcinoma-A Clinicopathologic Reassessment.
    Am J Dermatopathol 2016 Nov;38(11):809-812
    Department of Dermatology, University of Puerto Rico School of Medicine, San Juan, PR.
    Sebaceous carcinoma is an aggressive adnexal neoplasm with sebaceous differentiation. Few reports have described the histopathologic characteristics of the sebaceous carcinoma occurring extraocularly. Seventy-two cases of extraocular sebaceous carcinoma were identified from the database of a Dermatopathology Laboratory from January 1, 2007 to May 31, 2013. Read More

    Syringocystadenoma Papilliferum of the Scalp Arising from a Nevus Sebaceous.
    J Cutan Aesthet Surg 2016 Jul-Sep;9(3):204-206
    Department of General Surgery, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
    Syringocystadenoma papilliferum (SCAP) is a rare, benign tumour with varied presentations that arises from the apocrine glands and at times can lead to a diagnostic dilemma. A 53-year-old male presented with a 40-year history of a scalp nodule and a recent 2-year change in its character, and a sanguinopurulent discharge. Examination revealed a 4 cm × 2 cm firm nodule upon left side of the scalp vertex, actively discharging pus and blood. Read More

    The role of DOG1 immunohistochemistry in dermatopathology.
    J Cutan Pathol 2016 Nov 5;43(11):974-983. Epub 2016 Sep 5.
    Department of Diagnostic Pathology, Kainan Hospital, Yatomi, Japan.
    Background: This study was designed to evaluate the immunoexpression of DOG1, a specific marker expressed in gastrointestinal stromal tumors, in normal skin tissues and cutaneous epithelial tumors.

    Methods: DOG1 immunostaining extent, intensity and pattern were evaluated in 69 cutaneous apocrine/eccrine tumors, 11 sebaceous tumors, 46 follicular tumors, 52 keratinocytic tumors and perilesional normal tissues.

    Results: In normal tissues, DOG1 was expressed strongly in the intercellular canaliculi of eccrine glands, moderately in the myoepithelial cells of mammary and anogenital mammary-like glands, and weakly or not at all in the periphery of sebaceous lobules and the lower layer of epidermis and follicular infundibulum. Read More

    Nevus Sebaceous of Jadassohn With Eight Secondary Tumors of Follicular, Sebaceous, and Sweat Gland Differentiation.
    Am J Dermatopathol 2016 Nov;38(11):861-866
    *Shanghai Skin Disease Hospital, Tongji University, Shanghai, China †Ackerman Academy of Dermatopathology, New York, NY ‡Department of Dermatology, Kasr Alainy Faculty of Medicine, Cairo University, Egypt.

    Perineural Spread in Squamous Cell Carcinoma of the Face: An Overlooked Facet of Information on Imaging.
    J Maxillofac Oral Surg 2016 Sep 14;15(3):390-393. Epub 2015 Apr 14.
    Department of Radiology, Head and Neck Surgery, Narayana Multispeciality Hospital and Mazumdar Shaw Cancer Centre, Bommasandra, Bangalore, India.
    A case of malignant cutaneous lesion of the face diagnosed initially as sebaceous carcinoma, subsequently proven to be squamous cell carcinoma is presented. Patient was initially evaluated at an outside institution by computed tomography, which indicated extension of lesion to the maxillary sinus. Patient underwent local resection. Read More

    Incidence and survival of sebaceous carcinoma in the United States.
    J Am Acad Dermatol 2016 Dec 6;75(6):1210-1215. Epub 2016 Oct 6.
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio; Department of Dermatology, University Hospitals Case Medical Center, Cleveland, Ohio.
    Background: Information on risk factors, epidemiology, and clinical characteristics of sebaceous carcinoma (SC) is limited.

    Objective: We sought to analyze trends in SC in the United States from 2000 through 2012.

    Methods: We used data from the 18 registries of the Surveillance, Epidemiology, and End Results (SEER) Program from 2000 to 2012 to calculate the cause of death, relative frequencies/incidences, 5-/10-year Kaplan-Meier survival, hazard ratios, and incidence rates for SC. Read More

    Follicular Proliferation or Basal Cell Carcinoma? The first prospective UK study of this histological challenge during Mohs Surgery.
    Br J Dermatol 2016 Sep 28. Epub 2016 Sep 28.
    Guy's and St Thomas' NHS Foundation Trust, St John's Institute of Dermatology, London, United Kingdom.
    Mohs Micrographic Surgery (MMS) provides the highest cure rate for the treatment of BCC whilst maximising tissue conservation. Key to the success of MMS is the correct diagnosis of tumour. However, the facial area has a high density of follicular and sebaceous epithelia which can be difficult to distinguish from BCC. Read More

    Metastatic sebaceous cell carcinoma, review of the literature and use of electrochemotherapy as possible new treatment modality.
    Radiol Oncol 2016 Sep 19;50(3):308-12. Epub 2016 Jul 19.
    University of Turin, Department of Medical Sciences, Section of Dermatology, Turin, Italy.
    Background: Metastatic extraorbital sebaceous carcinoma is a rare event that could involve the head and neck. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial. Read More

    Lymphoepithelial cyst with sebaceous glands of the pancreas: a case report.
    Surg Case Rep 2016 Dec 15;2(1):98. Epub 2016 Sep 15.
    Department of Surgery, Shiga University of Medical Science, Seta-tsukinowacho, Otsu, Shiga, 520-2192, Japan.
    Background: Lymphoepithelial cyst (LEC) of the pancreas is a rare benign tumor. LEC with sebaceous glands of the pancreas is extremely rare, and its histogenesis remains unclear.

    Case Presentation: We present a 66-year-old man with an incidental finding of a cystic lesion at the neck of the pancreas. Read More

    Proposal of a Provisional Classification of Sebaceous Carcinoma Based on Hormone Receptor Expression and HER2 Status.
    Am J Surg Pathol 2016 Dec;40(12):1622-1630
    *Department of Pathology, Seoul National University College of Medicine Departments of ‡Ophthalmology §Biostatistics ¶Pathology, Seoul National University Boramae Hospital ∥Department of Pathology, Seoul National University Bundang Hospital, Seoul †Department of Pathology, Sacred Heart Hospital Hallym University, Anyang, Korea.
    Despite recent progress in comprehensive genetic analysis, little is known about the molecular pathogenesis of sebaceous carcinoma. On the basis of the ontogenic proximity of sebaceous and mammary glands, we designed an intrinsic classification for sebaceous carcinoma adapted from that of breast cancer and evaluated its clinical significance. We investigated 42 cases of sebaceous carcinoma, including 32 ocular and 10 extraocular cases. Read More

    Risk Factors for Local Recurrence or Metastasis of Eyelid Sebaceous Gland Carcinoma After Wide Excision With Paraffin Section Control.
    Am J Ophthalmol 2016 Nov 31;171:67-74. Epub 2016 Aug 31.
    Department of Oculoplastic, Orbital, & Lacrimal Surgery, Aichi Medical University Hospital, Nagakute, Aichi, Japan. Electronic address:
    Purpose: To identify risk factors for local recurrence and metastasis of sebaceous gland carcinoma (SGC) after wide excision with paraffin section control.

    Design: Retrospective, observational case-control study.

    Methods: Setting: Single institution. Read More

    Syringocystadenocarcinoma Papilliferum In Situ, a Variant of Cutaneous Adenocarcinoma In Situ: A Case Report With Literature Review.
    Am J Dermatopathol 2016 Oct;38(10):762-5
    *Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, China; †Department of Surgery, and ‡Department of Pathology and Laboratory Medicine and Department of Dermatology, Hofstra Northwell School of Medicine, NY.
    Syringocystadenocarcinoma papilliferum in situ, a variant of cutaneous adenocarcinoma in situ, is extremely rare. Only 9 cases have been published to date with 2 cases demonstrating pagetoid epidermal involvement. In this study, we report a case of syringocystadenocarcinoma papilliferum in situ with pagetoid epidermal involvement arising from a long-standing nevus sebaceus on the scalp of a 60-year-old woman. Read More

    Radiation Therapy for Primary Eyelid Cancers in Tunisia.
    Asian Pac J Cancer Prev 2016 ;17(7):3643-6
    Radiation oncology department, Salah Azaiez Institute, Tunis, Tunisia Email :
    Management of eyelid cancers is based on surgery and/or radiotherapy (RT). The treatment objective is to control tumors with acceptable functional and esthetic outcomes. The aim of this study was to evaluate the results of radiation therapy in management of epithelial eyelid cancers, reviewing retrospectively the clinical records of patients treated in our institution from January 1989 to December 2013. Read More

    Lrig1 Expression in Human Sebaceous Gland Tumors.
    Dermatopathology (Basel) 2016 Apr-Jun;3(2):44-54. Epub 2016 Jun 1.
    Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.
    Background: Sebaceous glands contribute significantly to the barrier functions of the skin. However, little is known about their homeostasis and tumorigenesis. Recently, increased expression of stem cell marker Lrig1 has been reported in sebaceous carcinoma-like tumors of K14ΔNLef1 transgenic mice. Read More

    Sebaceous Gland Carcinoma of the Lower Eyelid Reconstructed with a Composite Flap: A Case Report.
    J Clin Diagn Res 2016 Jun 1;10(6):PD16-8. Epub 2016 Jun 1.
    Resident, Department of Ophthalmology, Saveetha Medical College & Hospital , Thandalam, Kanchipuram, India .
    Sebaceous gland carcinomas are skin adnexal tumours occurring in the periocular region of elderly females. It is an uncommon malignancy usually involving the upper eyelid and has an indolent course. Mainstay of treatment is surgical excision. Read More

    Ceruminous Adenocarcinoma of External Auditory Canal: A Case Report.
    J Int Adv Otol 2016 Dec 3;12(3):341-344. Epub 2016 Aug 3.
    Department of Otorhinolaryngology, İstanbul Training and Research Hospital, İstanbul, Turkey.
    The external auditory canal contains ceruminous glands, which are modified apocrine sweat glands, along with sebaceous glands. Tumors that originate from ceruminous glands are very rare; thus, the classification, clinical behavior, and management of these tumors remain debatable. Here we present a case of ceruminous adenocarcinoma arising from the external auditory canal. Read More

    A Patient with Refractory Psoriasis Who Developed Sebaceous Carcinoma on the Neck during Cyclosporine Therapy and Showed Rapid Progression.
    Case Rep Dermatol 2016 May-Aug;8(2):136-41. Epub 2016 Jun 6.
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan.
    We report a patient who developed sebaceous carcinoma on the neck during therapy with immunosuppressive agents (cyclosporine, corticosteroid, methotrexate) for refractory psoriasis vulgaris, which showed rapid enlargement, leading to a fatal outcome. Multiple-organ metastases were detected. Weekly carboplatin + paclitaxel therapy resulted in the disappearance of tumor cells, but the patient died of febrile neutropenia. Read More

    A Patient with Giant Rippled-Pattern Sebaceoma in the Occipital Region.
    Case Rep Dermatol 2016 May-Aug;8(2):107-11. Epub 2016 May 23.
    Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
    A 72-year-old male visited a nearby hospital with a large tumor in his occipital region, which had existed since 20 years. Since malignant tumor was suspected, he was referred to our department. At the initial consultation, an elastic-hard, yellow-brown, sessile tumor, measuring 8 × 7 × 5 cm and with a flat surface, was observed in the occipital region. Read More

    p16 Expression Is Not a Surrogate Marker for High-Risk Human Papillomavirus Infection in Periocular Sebaceous Carcinoma.
    Am J Ophthalmol 2016 Oct 25;170:168-175. Epub 2016 Jul 25.
    Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts.
    Purpose: To evaluate the role of high-risk human papillomavirus (HR-HPV) infection in periocular sebaceous carcinoma (SC) using multiple methods of detection, and to determine whether p16 overexpression is present and can be used as a surrogate marker for HR-HPV.

    Design: Retrospective observational case series with laboratory investigations.

    Methods: Unstained paraffin sections of 35 cases of periocular SC were analyzed with immunohistochemistry for p16 and subjected to polymerase chain reaction (PCR) for HR-HPV. Read More

    Sebaceous lymphadenoma of the thymus: A clinicopathologic and immunohistochemical study of 2 cases.
    Hum Pathol 2016 Oct 29;56:189-93. Epub 2016 Jun 29.
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
    Two cases of primary sebaceous lymphadenoma of the thymus are presented. The patients were a man and a woman 58 and 77 years old, respectively. The female patient had a history of breast carcinoma and on follow-up was identified to have an anterior mediastinal mass; the male patient did not have any history of malignancy, and the tumor was discovered during a chest radiographic evaluation when the patient presented with symptoms of fatigue, chest pain, and dyspnea. Read More

    Molluscum Contagiosum Infection Involving a Benign Epidermoid Cyst in an Immunocompetent Patient.
    Skinmed 2016 1;14(2):151-2. Epub 2016 Apr 1.
    Department of Dermatology and Pathology, Infanta Margarita Hospital, Córdoba, Spain.
    A 78-year-old man presented with a round- to oval-shaped nodule on his right eyebrow. The lesion first developed 5 years ago as a small solitary white nodule and subsequently enlarged over the past 2 years. His medical history was unremarkable. Read More

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