Chemical imaging of aggressive basal cell carcinoma using time-of-flight secondary ion mass spectrometry.
- Marwa Munem,
- Oscar Zaar,
- Kelly Dimovska Nilsson,
- Noora Neittaanmäki,
- John Paoli,
- John S Fletcher
Biointerphases 2018 Jan 12;13(3):03B402. Epub 2018 Jan 12.
Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg 412 96, Sweden.
A set of basal cell carcinoma samples, removed by Mohs micrographic surgery and pathologically identified as having an aggressive subtype, have been analyzed using time-of-flight secondary ion mass spectrometry (SIMS). The SIMS analysis employed a gas cluster ion beam (GCIB) to increase the sensitivity of the technique for the detection of intact lipid species. The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface. Read More