2,106 results match your criteria Sebaceous Carcinoma


Sebaceous Carcinoma of the Nose: A Rare Presentation of an Uncommon Tumor.

Eplasty 2019 27;19:ic11. Epub 2019 Mar 27.

Department of Dermatology, Largo Medical Center, Nova Southeastern University, Largo, Fla.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448217PMC
March 2019
1 Read

Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing
April 2019
1 Read

Basal Cell Carcinoma on a Nevus Sebaceous of Jadassohn: A Case Report.

J Clin Aesthet Dermatol 2019 Mar 1;12(3):40-43. Epub 2019 Mar 1.

Drs. Paninson, Trope, and Ramos-e-Silva are with the Sector of Dermatology, Postgraduation Course in Dermatology at the University Hospital and School of Medicine, Federal University of Rio de Janeiro in Rio de Janeiro, Brazil.

The nevus sebaceous of Jadassohn, usually present at birth, is a hamartoma composed predominantly of sebaceous glands, which can progress to benign and malignant tumors. Malignant neoplasms on the nevus sebaceous occur in about 2.5 percent of cases, with basal cell carcinoma accounting for 1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440703PMC
March 2019
2 Reads

Heterogeneity of PD-L1 expression and CD8 tumor-infiltrating lymphocytes among subtypes of cutaneous adnexal carcinomas.

Cancer Immunol Immunother 2019 Apr 5. Epub 2019 Apr 5.

Pathology Department, INSERM UMR_S1165, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (APHP), 1 Avenue Claude Vellefaux, 75010, Paris, France.

Background: Adnexal carcinomas are rare and heterogeneous skin tumors, for which no standard treatments exist for locally advanced or metastatic tumors.

Aim Of The Study: To evaluate the expression of PD-L1 and CD8 in adnexal carcinomas, and to study the association between PD-L1 expression, intra-tumoral T cell CD8 infiltrate, and metastatic evolution.

Materials And Methods: Eighty-three adnexal carcinomas were included. Read More

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http://link.springer.com/10.1007/s00262-019-02334-8
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http://dx.doi.org/10.1007/s00262-019-02334-8DOI Listing
April 2019
3 Reads

The practice patterns in the management of sebaceous carcinoma of the eyelid in the Asia Pacific region.

Eye (Lond) 2019 Apr 5. Epub 2019 Apr 5.

Department of Ophthalmology, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong SAR, China.

Purpose: To determine the practice patterns of ophthalmic plastic surgeons regarding the management of eyelid sebaceous carcinoma (SC).

Methods: An electronic survey was distributed to oculoplastic surgical colleagues in the Asia Pacific region requesting clinical information and treatment approaches to SC.

Results: The responses from 192 respondents from the Asia Pacific region was included and analyzed in this study. Read More

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http://dx.doi.org/10.1038/s41433-019-0432-0DOI Listing

Vimentin overexpression as a novel poor prognostic biomarker in eyelid sebaceous gland carcinoma.

Br J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ocular Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Vimentin is an intermediate-sized filament which is highly expressed in mesenchymal cells and is associated with epithelial-mesenchymal transition (EMT). EMT markers ZEB2 and Slug lead to Vimentin overexpression and E-cadherin loss, resulting in invasion and metastasis. However, the status of Vimentin remains unexplored in eyelid sebaceous gland carcinoma (SGC). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313285DOI Listing
April 2019
1 Read

Lacrimal Sac Sebaceous Carcinoma.

Ophthalmic Plast Reconstr Surg 2019 Mar 26. Epub 2019 Mar 26.

Oculoplastic Department, Bristol Eye Hospital, Bristol, United Kingdom.

Sebaceous carcinoma is an aggressive malignancy with a high mortality rate that commonly arises in the periorbital area. Rarely, the lacrimal apparatus may be involved by either contiguous or noncontiguous spread. The authors describe 2 unusual cases of sebaceous carcinoma in the lacrimal sac, presenting as a medial canthal mass simulating chronic dacryocystitis. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001386DOI Listing
March 2019
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An Update on Eyelid Sebaceous Cell Carcinoma.

Int Ophthalmol Clin 2019 ;59(2):1-11

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http://dx.doi.org/10.1097/IIO.0000000000000272DOI Listing
January 2019

Muir-Torre Syndrome Appropriate Use Criteria: Effect of Patient Age on Appropriate Use Scores.

J Cutan Pathol 2019 Mar 20. Epub 2019 Mar 20.

Bey Dermatology and Cosmetic Surgery, Spring Hill, FL.

Background: Muir-Torre syndrome (MTS) is a rare inherited syndrome, with an increased risk of sebaceous and visceral malignancy. Prior reports suggest screening for mismatch repair (MMR) deficiency may be warranted in patients < 50 years and when sebaceous neoplasms are located on a non-head and neck location. Previously, appropriate use criteria (AUC) were developed for clinical scenarios in patients > 60 years concerning the use of MMR protein immunohistochemistry (MMRP-IHC). Read More

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http://dx.doi.org/10.1111/cup.13459DOI Listing
March 2019
1 Read
1.560 Impact Factor

Mohs micrographic surgery versus wide local excision for sebaceous adenocarcinoma of the eyelid : Analysis of a national database.

J Plast Reconstr Aesthet Surg 2019 Mar 2. Epub 2019 Mar 2.

Baylor College of Medicine, Houston, Texas, United States.

Background: Sebaceous adenocarcinomas are rare and potentially aggressive tumors, which typically arise in the periocular region. Surgical treatments for eyelid sebaceous adenocarcinomas include Mohs micrographic surgery (MMS) and wide local excision (WLE). The objective of this study was to compare long-term survival outcomes of MMS versus WLE techniques for eyelid sebaceous adenocarcinomas. Read More

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http://dx.doi.org/10.1016/j.bjps.2019.02.009DOI Listing
March 2019
1 Read

Clinicopathologic Characteristics and Predictors Affecting Survival Outcome of Eyelid Malignancy.

J Craniofac Surg 2019 Mar 12. Epub 2019 Mar 12.

Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

The aim of this study was to determine the clinicopathologic characteristics and evaluate the prognostic factors in eyelid malignancies. This was a retrospective, comparative, case series of 70 patients with eyelid malignancies. The mean age at diagnosis was 72. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005341DOI Listing
March 2019
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Predictors of Local Recurrence for Eyelid Sebaceous Carcinoma: Questionable Value of Routine Conjunctival Map Biopsies for Detection of Pagetoid Spread.

Ophthalmic Plast Reconstr Surg 2019 Mar 8. Epub 2019 Mar 8.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.

Purpose: To identify clinicopathologic factors associated with local recurrence of eyelid sebaceous carcinoma and determine whether routine conjunctival map biopsies are necessary to detect pagetoid spread.

Methods: The authors searched PubMed for articles on eyelid sebaceous carcinoma and pagetoid spread published in English during 1982 to 2018, and they reviewed 99 consecutive patients with eyelid sebaceous carcinoma who underwent surgical excision with frozen section control of margins performed by 1 author (BE) during 1999 to 2017.

Results: Local recurrence rates after surgery were 5% to 25% in the literature and 6% in the authors' cohort. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001343DOI Listing
March 2019
1 Read

Comparison of Mohs Surgery and Surgical Excision in the Treatment of Localized Sebaceous Carcinoma.

Dermatol Surg 2019 Feb 28. Epub 2019 Feb 28.

Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: It remains controversial if Mohs surgery is superior to surgical excision in treating localized sebaceous carcinoma.

Objective: To compare Mohs surgery and surgical excision for treating patients with localized sebaceous carcinoma.

Materials And Methods: The US National Cancer Database was used to identify patients with histologically confirmed Stage 0 to 2 sebaceous carcinoma from 2004 to 2014. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001780DOI Listing
February 2019
2 Reads

Successful Treatment with Taxane-Based Chemotherapy in Advanced Sebaceous Carcinoma: A Case Report and Literature Review.

Case Rep Oncol 2019 Jan-Apr;12(1):47-52. Epub 2019 Jan 11.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

For sebaceous carcinoma (SC), a rare malignant tumor, no standard chemotherapy regimen for patients with distant metastasis has been studied. We experienced a case of eyelid SC with multiple lung metastases that responded to combination chemotherapy with carboplatin and paclitaxel with 11-month progression-free survival (PFS). This patient also responded to second-line treatment with docetaxel, another taxane, with 7-month PFS, resulting in at least 18 months of survival at the time of reporting. Read More

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http://dx.doi.org/10.1159/000493850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381883PMC
January 2019
1 Read

Sebaceous carcinoma in a mature teratoma of the ovary.

Autops Case Rep 2018 Oct-Dec;8(4):e2018060. Epub 2018 Oct 9.

Pathodiagnose Pathology Laboratory. Chapecó, SC, Brazil.

The finding of a sebaceous carcinoma in a mature teratoma is rare in human pathology, with fewer than 10 cases currently reported in the literature. In this article, we report a case of sebaceous carcinoma in a mature teratoma of the ovary in a 59-year-old patient and discuss its histological findings. Read More

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http://dx.doi.org/10.4322/acr.2018.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360825PMC
October 2018
5 Reads

Biophysical basis of skin cancer margin assessment using Raman spectroscopy.

Biomed Opt Express 2019 Jan 7;10(1):104-118. Epub 2018 Dec 7.

Department of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton Street C0800, Austin, TX 78712, USA.

Achieving adequate margins during tumor margin resection is critical to minimize the recurrence rate and maximize positive patient outcomes during skin cancer surgery. Although Mohs micrographic surgery is by far the most effective method to treat nonmelanoma skin cancer, it can be limited by its inherent required infrastructure, including time-consuming and expensive on-site histopathology. Previous studies have demonstrated that Raman spectroscopy can accurately detect basal cell carcinoma (BCC) from surrounding normal tissue; however, the biophysical basis of the detection remained unclear. Read More

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http://dx.doi.org/10.1364/BOE.10.000104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363200PMC
January 2019
1 Read
3.648 Impact Factor

Sebaceous Carcinoma of Upper Eyelid Presenting as Submandibular Lymphadenopathy.

J Cytol 2019 Jan-Mar;36(1):73-74

Department of Pathology, KEM Hospital, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/0970-9371.250131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343392PMC
February 2019
2 Reads

Bowen disease with invasive mucin-secreting sweat gland differentiation: Report of a case and review of the literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Central Zone (Halifax), Halifax, Nova Scotia, Canada.

Bowen disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically, these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. Read More

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http://dx.doi.org/10.1111/cup.13437DOI Listing
February 2019
3 Reads

[Histopathological study of basaloid follicular hamartoma].

Ann Dermatol Venereol 2019 Mar 26;146(3):181-191. Epub 2019 Jan 26.

Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.

Introduction: Basaloid follicular hamartoma (BFH) is a rare tumor first described in 1985. It bears clinical and histologic similarities with basal cell carcinoma (BCC), in particular the so-called infundibulocystic form. We performed a single-center clinicopathological study of a series of typical cases of this entity that is occasionally difficult to diagnose. Read More

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http://dx.doi.org/10.1016/j.annder.2018.12.007DOI Listing
March 2019
2 Reads

Ectopic breast carcinoma presenting as sebaceous cyst left axilla.

BMJ Case Rep 2019 Jan 24;12(1). Epub 2019 Jan 24.

Department of Histopathology, Wythenshawe Hospital, Manchester, UK.

A 43-year-old woman with a positive family history of breast cancer presented with a painless lump in her left axilla for 2 years. Clinical diagnosis was a left axillary sebaceous cyst as the lump was inseparable from the skin. The lesion was excised under local anaesthesia and reported as breast tissue widely infiltrated by an invasive ductal carcinoma (grade 2). Read More

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http://dx.doi.org/10.1136/bcr-2018-224789DOI Listing
January 2019
1 Read

Multiple benign adnexal tumours: Anything but benign.

Australas J Dermatol 2019 Jan 22. Epub 2019 Jan 22.

St Vincent's Hospital, Sydney, New South Wales, Australia.

Muir Torre syndrome is an autosomal dominant disorder characterised by germline mutations in mismatch repair genes involved in DNA repair, leading to microsatellite instability and a propensity to tumour formation. We report a case of a 67-year-old gentleman who underwent biopsy of a smooth nodular lesion on the nasal tip, histopathologically consistent with sebaceous adenoma. Immunohistochemistry suggested a loss of MSH6. Read More

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http://doi.wiley.com/10.1111/ajd.12989
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http://dx.doi.org/10.1111/ajd.12989DOI Listing
January 2019
21 Reads

HMG-CoA reductase expression in human eyelid tissue and in a human meibomian gland epithelial cell line.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 21;257(4):785-790. Epub 2019 Jan 21.

Save Sight Institute, University of Sydney, Sydney Eye Hospital Campus, 8 Macquarie Street, Sydney, NSW, 2000, Australia.

Purpose: 3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme of cholesterol production, has been found to contribute to lipid secretion from skin sebaceous glands and hair follicles. We assessed for HMGCR expression in human eyelid tissue and in immortalized human meibomian gland epithelial cells (HMGECs) using immunohistochemistry.

Methods: Full thickness human eyelid specimens in archival paraffin blocks were obtained. Read More

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http://dx.doi.org/10.1007/s00417-019-04247-9DOI Listing
April 2019
15 Reads

Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors.

J Dermatol 2019 Mar 21;46(3):249-258. Epub 2019 Jan 21.

Institute for Hematopathology, Hamburg, Germany.

The histogenesis of extraocular sebaceous carcinomas is - in contrast to ocular sebaceous carcinomas - unclear, and information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce. This study attempts to elucidate the histogenesis of sebaceous tumors, using multicolor immunofluorescence stainings to analyze 21 cases of sebaceous tumors (six each of extraocular sebaceous carcinoma, sebaceous adenoma and sebaceoma, and three cases of steatocystomas) and eight cases of normal sebaceous glands for p63, several keratins, androgen receptor, adipophilin, epithelial membrane antigen (EMA) and Ki-67. The data of this observational study provide evidence for the existence of two subpopulations of progenitors in normal sebaceous glands: (i) p63 K5 progenitors which generate the K10 luminal cells of sebaceous ducts; and (ii) p63 K5 K7 progenitors which finally generate K7 adipophilin EMA sebocytes. Read More

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http://dx.doi.org/10.1111/1346-8138.14765DOI Listing
March 2019
7 Reads

Cytokeratin expression in epidermal stem cells in skin adnexal tumors.

Oncol Lett 2019 Jan 8;17(1):927-932. Epub 2018 Nov 8.

Department of Pathology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China.

The expression levels of seven types of cytokeratin (CK) in different kinds of skin adnexal tumors were evaluated. One hundred and thirty-two patients with different kinds of skin adnexal tumors admitted and treated in the Department of Dermatology of Dongying People's Hospital from May 2013 to May 2015 were selected and underwent tissue section staining. Another 20 cases of normal skin were enrolled as the control group. Read More

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http://dx.doi.org/10.3892/ol.2018.9679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312935PMC
January 2019
2 Reads

Mohs micrographic surgery for eyelid sebaceous carcinoma: a multicenter cohort of 360 patients.

J Am Acad Dermatol 2019 Jan 9. Epub 2019 Jan 9.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. Electronic address:

Background: The decision to perform Mohs micrographic surgery (MMS) or wide local excision (WLE) for eyelid sebaceous carcinoma (SC) is controversial.

Objective: To compare local recurrence, metastasis, and tumor-related mortality of patients with eyelid SC who were initially treated with MMS versus WLE.

Methods: A multicenter cohort study. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.053DOI Listing
January 2019
1 Read

Primary sebaceous carcinoma of lacrimal gland: A case report and review of literature.

World J Clin Cases 2018 Dec;6(16):1194-1198

Departments of Radiation Oncology, Dankook University Hospital, Dankook University College of Medicine, Cheonan 31116, South Korea.

Background: Primary sebaceous carcinoma of lacrimal gland (SCLG) is extremely rare. Due to its clinical characteristics, it is often misdiagnosed. It is known to be aggressive so delay in diagnosis can increase the chance of local recurrence and metastasis. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i16.1194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306633PMC
December 2018
3 Reads

Frequent TLE1 Expression in Cutaneous Neoplasms.

Am J Dermatopathol 2019 Jan;41(1):1-6

Dermatopathologist, Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

TLE1 immunohistochemistry is widely used as a biomarker for synovial sarcoma. Recently, we identified TLE1 expression in a subset of melanomas and noted staining in sebaceous glands and follicular epithelium. TLE1 immunohistochemistry has not been well studied in cutaneous tumors. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001186DOI Listing
January 2019
3 Reads

A squamous cell carcinoma in a young woman with Lynch syndrome.

Fam Cancer 2019 Apr;18(2):193-196

Department of Dermatology, Academic Medical Centre, Amsterdam, The Netherlands.

Lynch syndrome (LS) is an autosomal-dominant inherited disorder characterized by a predisposition to colorectal cancer and extracolonic cancers (particularly endometrium, ovary, stomach, small bowel, hepatobiliary tract, pancreas, urothelial tract, brain, and skin). Muir-Torre syndrome (MTS) is considered a phenotypical variant of LS, where patients develop sebaceous neoplasms and keratoacanthomas. Currently, only few studies and case reports suggest an association between LS and other skin cancers, such as Bowens' disease, melanoma and squamous cell carcinoma (SCC). Read More

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http://dx.doi.org/10.1007/s10689-018-00113-5DOI Listing
April 2019
3 Reads

Periocular Sebaceous Carcinoma With Apocrine Differentiation: A Case Report and Review of the Literature.

Int J Surg Pathol 2018 Dec 6:1066896918816806. Epub 2018 Dec 6.

1 Centro Hospitalar São João, Porto, Portugal.

A 61-year-old man presented with a dome-shaped tumor in the right eyelid. Histology revealed a cutaneous neoplasm with lobular growth pattern. It was composed of large basaloid cells, cells with sebaceous differentiation, and glandular structures with apocrine features. Read More

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http://dx.doi.org/10.1177/1066896918816806DOI Listing
December 2018
3 Reads

Thymic epithelial neoplasms with sebaceous differentiation: a clinicopathological and immunohistochemical study of 8 cases.

Hum Pathol 2019 Apr 8;86:124-128. Epub 2018 Dec 8.

Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston 77030, TX, USA. Electronic address:

Eight cases of primary thymic epithelial neoplasms corresponding to 7 thymomas and 1 thymic carcinoma with sebaceous differentiation are presented. The patients are 5 men and 3 women between the ages of 45 and 63 years (average, 54 years) who presented with nonspecific symptoms related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.030DOI Listing
April 2019
9 Reads

Malignant eyelid tumors: Are intra-operative rapid frozen section and permanent section diagnoses of surgical margins concordant?

Int Ophthalmol 2018 Dec 8. Epub 2018 Dec 8.

Ophthalmic Pathology Laboratory (DKM), L V Prasad Eye Institute, Hyderabad, India.

Purpose: To study the concordance between intra-operative rapid frozen section and permanent section diagnoses of surgical margins following wide surgical excisional biopsy of malignant eyelid tumors.

Methods: This is a retrospective study of 120 cases and 429 frozen section slides.

Results: Of 120 cases, 75 (63%) had sebaceous gland carcinoma, 34 (28%) had basal cell carcinoma, and 11 (9%) had squamous cell carcinoma. Read More

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http://dx.doi.org/10.1007/s10792-018-1058-0DOI Listing
December 2018
4 Reads

Immunoreactivity for Sox10 in Basaloid Neoplasms of The Skin.

Appl Immunohistochem Mol Morphol 2019 Feb;27(2):114-118

Section of Dermatopathology, Division of Surgical Pathology-Cytopathology, University of Virginia Medical Center, Charlottesville, VA.

Basaloid tumors of the skin pose a diagnostic challenge to pathologists, because the differential diagnosis is broad, sometimes with subtle differentiating features. We evaluated SOX10 expression in 120 primary cutaneous tumors with epidermal, sweat glandular, neuroendocrine/neuroectodermal, follicular, and sebaceous lineages. Our findings were compared with those of previous studies that evaluated SOX10 in tumors of the skin. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000721DOI Listing
February 2019
3 Reads

Identification and regulation pattern analysis of long noncoding RNAs in meibomian gland carcinoma.

Epigenomics 2019 Feb 7;11(4):381-400. Epub 2018 Dec 7.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China.

Aim: To identify long noncoding RNAs (lncRNAs) and to elucidate regulation patterns of lncRNAs in meibomian gland carcinoma (MGC).

Materials & Methods: We used RNA-Seq, gene ontology, ClueGO, Ingenuity Pathway Analysis and co-expression network analyses to profile the expression and regulation patterns of lncRNAs and mRNAs in MGC.

Results: We identified 500 lncRNAs and 326 mRNAs as differentially expressed. Read More

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http://dx.doi.org/10.2217/epi-2018-0182DOI Listing
February 2019
5 Reads

Clinico-pathological predictors of mismatch repair deficiency in sebaceous neoplasia: A large case series from a single Australian private pathology service.

Australas J Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Clinical Pathology, Colorectal Oncogenomics Group, The University of Melbourne, Parkville, Victoria, Australia.

Background/objectives: Loss of expression of mismatch repair (MMR) proteins is frequently observed in sebaceous skin lesions and can be a herald for Lynch syndrome. The aim of this study was to identify clinico-pathological predictors of MMR deficiency in sebaceous neoplasia that could aid dermatologists and pathologists in determining which sebaceous lesions should undergo MMR immunohistochemistry (IHC).

Methods: An audit of sebaceous skin lesions (excluding hyperplasia) where pathologist-initiated MMR IHC was performed between January 2009 to December 2016 was undertaken from a single pathology practice identifying 928 lesions from 882 individuals. Read More

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http://doi.wiley.com/10.1111/ajd.12958
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http://dx.doi.org/10.1111/ajd.12958DOI Listing
December 2018
20 Reads

Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma.

Pathology 2019 Jan 28;51(1):67-73. Epub 2018 Nov 28.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Hong Kong. Electronic address:

Malignant transformation of benign mature ovarian teratoma can result in a wide spectrum of cancer, including a variety of carcinoma, sarcoma, or melanoma. The role of mismatch repair defects in such malignant transformation is still elusive. In view of current immunotherapy, the role of mismatch repair deficiency can have significant implications on therapeutic strategy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183034
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http://dx.doi.org/10.1016/j.pathol.2018.09.061DOI Listing
January 2019
14 Reads

Clinicopathological characteristics of breast sebaceous adenocarcinoma.

Pol J Pathol 2018;69(3):226-233

Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. Read More

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http://dx.doi.org/10.5114/pjp.2018.79542DOI Listing
January 2018
4 Reads

Primary cutaneous apocrine carcinoma arising within a nevus sebaceus.

Cutis 2018 Oct;102(4):291-294

Nova Southeastern University College of Osteopathic Medicine/Largo Medical Center, Florida, USA.

Nevus sebaceus (NS)(organoid nevus) is a benign follicular neoplasm that commonly occurs on the scalp, face, or neck. With time, it may give rise to benign or malignant tumors such as trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma (BCC). Rarely, other types of neoplasms may develop. Read More

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October 2018
11 Reads

Les difficultés du diagnostic : du carcinome basocellulaire aux tumeurs trichoblastiques: From basal cell carcinoma to trichoblastic tumors: a diagnostic challenge.

Authors:
B Cribier

Ann Dermatol Venereol 2018 Nov;145 Suppl 5:VS3-VS11

Clinique dermatologique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address:

Basal cell carcinoma (BCC) is a very common tumor, of which the diagnosis is generally easy. Clinical prediction of histopathological subtype however is however often difficult, i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638183125
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http://dx.doi.org/10.1016/S0151-9638(18)31254-7DOI Listing
November 2018
16 Reads

A retrospective study of 2228 cases with eyelid tumors.

Int J Ophthalmol 2018 18;11(11):1835-1841. Epub 2018 Nov 18.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China.

Aim: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015.

Methods: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.11.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232338PMC
November 2018
17 Reads

Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations.

Clin Cancer Res 2019 Feb 12;25(4):1280-1290. Epub 2018 Nov 12.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: Ocular adnexal (OA) sebaceous carcinoma is an aggressive malignancy of the eyelid and ocular adnexa that frequently recurs and metastasizes, and effective therapies beyond surgical excision are lacking. There remains a critical need to define the molecular-genetic drivers of the disease to understand carcinomagenesis and progression and to devise novel treatment strategies.

Experimental Design: We present next-generation sequencing of a targeted panel of cancer-associated genes in 42 and whole transcriptome RNA sequencing from eight OA sebaceous carcinomas from 29 patients. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-18-1688DOI Listing
February 2019
12 Reads
8.722 Impact Factor

Lamellar rotation surgery: a new procedure for repairing upper eyelid defects.

Authors:
Qingji Li

BMC Ophthalmol 2018 Nov 7;18(1):291. Epub 2018 Nov 7.

Department of Oculoplastic and Reconstructive Surgery, Tianjin Aier Eye Hospital, No.102, Fukang Road, Nankai District, Tianjin, 300190, People's Republic of China.

Background: To report "Lamellar Rotation Surgery",a new technique for repairing large and moderate full-thickness upper eyelid defects.

Methods: A two-stage technique is described in which a vertical incision is made in the tarsus of the lower eyelid with elevation of the lateral posterior lamella while sparing the lower eyelid orbicularis and skin to be rotated superiorly to form the reconstructed posterior lamella of the upper eyelid. Additionally, a lateral periosteal flap is used to reconstruct the lateral canthal tendon, and a McGregor procedure is used to reconstruct the anterior lamella of the upper eyelid. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
Publisher Site
http://dx.doi.org/10.1186/s12886-018-0958-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222999PMC
November 2018
16 Reads

Dermatological conditions seen in renal transplant recipients in a Singapore tertiary hospital.

Singapore Med J 2018 Oct;59(10):519-523

Department of Dermatology, Singapore General Hospital, Singapore.

Introduction: Lifelong immunosuppression after renal transplant exerts effects on the recipients' skin, including skin infections, skin cancers and drug-induced skin disorders. Our study aimed to determine the epidemiology of skin conditions among renal transplant recipients in the largest tertiary hospital in Singapore.

Methods: We reviewed the medical records of kidney transplant recipients at Singapore General Hospital, Singapore, between 1 January 2003 and 31 December 2013. Read More

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http://dx.doi.org/10.11622/smedj.2018126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199188PMC
October 2018
19 Reads

Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid - a population-based analysis.

Orbit 2018 Oct 29:1-8. Epub 2018 Oct 29.

a Department of Ophthalmology , Oakland University William Beaumont School of Medicine , Royal Oak , MI , USA.

Purpose: To evaluate prognostic factors and survival of patients with sebaceous carcinoma of the eyelid through a population-based analysis.

Methods: A total of 940 patients with primary sebaceous carcinoma of the eyelid were derived from the Surveillance, Epidemiology, and End Results (SEER) database in the United States from 1973 to 2013. Kaplan-Meier univariate analysis and Cox Regression multivariate analysis were performed to examine prognostic factors in overall survival (OS). Read More

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http://dx.doi.org/10.1080/01676830.2018.1505922DOI Listing
October 2018
7 Reads

Merkel cells in extraocular sebaceous carcinoma.

J Cutan Pathol 2019 Mar 27;46(3):171-174. Epub 2018 Nov 27.

Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, California.

Introduction: Mature sebaceous glands do not contain Merkel cells. Neither do sebaceous tumors in the vast majority of cases. Recently, however, it was showed that rare sebaceous adenomas with a carcinoid-like or labyrinthine pattern can contain intratumoral Merkel cells. Read More

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http://doi.wiley.com/10.1111/cup.13381
Publisher Site
http://dx.doi.org/10.1111/cup.13381DOI Listing
March 2019
10 Reads

Malignant Transformation of Mature Cystic Teratoma: Is Squamous Cell Carcinoma Different From the Other Types of Neoplasm?

Int J Gynecol Cancer 2018 11;28(9):1650-1656

Department of Obstetrics and Gynecology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.

Objectives: Malignant transformation of mature cystic teratoma (MCT) is rare. Unlike squamous cell carcinoma (SCC) in MCT, the other types of neoplasm in MCT have not been discussed in publications. We analyzed the clinical characteristics and prognosis of the other types of neoplasm (non-SCC) compared with those of SCC. Read More

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http://dx.doi.org/10.1097/IGC.0000000000001375DOI Listing
November 2018
18 Reads

An Ulcerated Reddish Nodule of the Chest: When You See, Think ….

Dermatopathology (Basel) 2018 Jul-Sep;5(3):117-120. Epub 2018 Sep 19.

Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

A 97-year-old man with a previous personal history of multiple nonmelanoma skin cancers presented with a fast-growing, ulcerated reddish nodule on his chest. The nodule was surgically removed, and hematoxylin and eosin stains of the specimen showed an asymmetrical, nonpigmented lesion with architectural and structural impairment, round cells with clear, whitish, foamy cytoplasm, multiple dermal mitoses and nuclear pleomorphism. Our first hypothesis was sebaceous carcinoma, a rare malignant neoplasm derived from epithelial cells showing sebaceous differentiation. Read More

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https://www.karger.com/Article/FullText/491923
Publisher Site
http://dx.doi.org/10.1159/000491923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180268PMC
September 2018
16 Reads

Super-Thick Amniotic Membrane Graft for Ocular Surface Reconstruction.

Am J Ophthalmol 2019 Feb 9;198:45-53. Epub 2018 Oct 9.

The New York Eye Cancer Center, New York, New York, USA.

Purpose: The purpose of this study was to evaluate super-thick amniotic membrane grafts (ST-AMGs) for ocular surface reconstruction.

Design: Retrospective, interventional case series.

Methods: This was a single-center study of clinical practice that included select patients with typically large ocular surface abnormalities that required reconstruction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183057
Publisher Site
http://dx.doi.org/10.1016/j.ajo.2018.09.035DOI Listing
February 2019
5 Reads