775 results match your criteria Sebaceous Adenoma


Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: case report and review of nevus sebaceus-associated conditions.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

School of Medicine, University of California San Diego, La Jolla, CA.

Nevus sebaceus is a benign skin hamartoma of congenital onset that grows during puberty, and in adulthood can develop secondary benign and malignant neoplasms. The most common benign neoplasms occurring in nevus sebaceus are believed to be syringocystadenoma papilliferum, trichilemmoma, and trichoblastoma. A patient with nevus sebaceus developed not only syringocystadenoma papilliferum but also prurigo nodularis within her hamartomatous lesion; multiple biopsies were necessary to establish the diagnoses. Read More

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February 2020

Increased Lipid Accumulation under Hypoxia in SZ95 Human Sebocytes.

Dermatology 2020 Feb 21:1-11. Epub 2020 Feb 21.

Department of Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea,

Background: Excessive sebum is produced by specialized cells called sebocytes and is considered a cause or consequence of acne, sebaceous cysts, hyperplasia, and sebaceous adenoma.

Objective: To report changes in lipid accumulation in human sebocytes under hypoxia, which occurs under conditions of seborrhea.

Methods: Sebocytes from the immortalized human gland cell line SZ95 were cultured under conditions of hypoxia for 48 h; lipid formation was confirmed by Nile red and Oil Red O staining. Read More

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http://dx.doi.org/10.1159/000505537DOI Listing
February 2020

Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.

Diagn Cytopathol 2020 May 22;48(5):424-429. Epub 2020 Jan 22.

Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri.

Background: Sebaceous lymphadenomas and sebaceous lymphadenocarcinomas are uncommon neoplasms occurring predominately within the parotid gland. Cytomorphology of these neoplasms is rarely reported. Occasional reports have discussed the cytomorphological features of these neoplasms but criteria distinguishing sebaceous lymphadenomas from lymphadenocarcinomas have not been described. Read More

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http://dx.doi.org/10.1002/dc.24357DOI Listing

Preputial gland adenoma in a wild nutria (): a case report.

J Vet Sci 2020 Jan;21(1):e1

Department of Veterinary Pathology, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea.

Tumor incidence in wild mammals is reportedly very low. Wild nutria, a large rodent, is known to carry many infectious diseases, but rarely exhibits neoplastic diseases. We necropsied a male wild nutria and found a large nodular mass in the left inguinal region, adjacent to the penis. Read More

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http://dx.doi.org/10.4142/jvs.2020.21.e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000891PMC
January 2020
1.164 Impact Factor

Sebaceous Adenoma in a Patient With Visceral Malignancies.

Ophthalmic Plast Reconstr Surg 2020 Jan 8. Epub 2020 Jan 8.

Division of Ophthalmology, NorthShore University HealthSystem, Chicago, Illinois, U.S.A.

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http://dx.doi.org/10.1097/IOP.0000000000001513DOI Listing
January 2020
0.914 Impact Factor

Update on the pathology, genetics and somatic landscape of sebaceous tumours.

Histopathology 2020 Apr 17;76(5):640-649. Epub 2020 Mar 17.

Department of Pathology & Laboratory Medicine, The Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Cutaneous sebaceous neoplasms show a predilection for the head and neck area of adults and include tumours with benign behaviour, sebaceous adenoma and sebaceoma, and sebaceous carcinoma with potential for an aggressive disease course at the malignant end of the spectrum. The majority of tumours are solitary and sporadic, but a subset of tumours may be associated with Lynch syndrome, also known as hereditary non-polyposis colon cancer (HNPCC) and previously referred to as Muir-Torre syndrome (now known to be part of Lynch syndrome). This review provides an overview of the clinical and histological features of cutaneous sebaceous neoplasia with an emphasis on differentiating features and differential diagnosis. Read More

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http://dx.doi.org/10.1111/his.14044DOI Listing

Sebaceoma on the scalp simulating a malignant pigmented neoplasia.

An Bras Dermatol 2019 Sep - Oct;94(5):590-593. Epub 2019 Sep 30.

ID - Investigação em Dermatologia, Rio de Janeiro, RJ, Brazil.

The correct identification of pigmented nodular lesions of the scalp is often challenging. Despite the importance of clinical patterns and dermoscopy, important adjuvant tools that are usually helpful, their interpretation sometimes is not clear-cut. Here, the authors discuss a case of sebaceoma mimicking a malignant pigmented neoplasia, with conclusive histopathology. Read More

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http://dx.doi.org/10.1016/j.abd.2019.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857578PMC
December 2019

Tumors of the conjunctiva and cornea.

Indian J Ophthalmol 2019 12;67(12):1930-1948

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Tumors of the conjunctiva and cornea comprise a large and varied spectrum of conditions. These tumors are grouped into two major categories of congenital and acquired lesions. The acquired lesions are further subdivided based on origin of the mass into surface epithelial, melanocytic, vascular, fibrous, neural, histiocytic, myxoid, myogenic, lipomatous, lymphoid, leukemic, metastatic and secondary tumors. Read More

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http://dx.doi.org/10.4103/ijo.IJO_2040_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896532PMC
December 2019

Ocular Adnexal Adenomatoid Sebaceous Gland Hyperplasia: A Clinical and Immunopathologic Analysis in Relation to the Muir-Torre Syndrome.

Ophthalmic Plast Reconstr Surg 2020 Jan/Feb;36(1):e6-e12

Department of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.

The purpose of this study is to codify the microscopic diagnostic criteria for ocular adnexal brow and caruncular sebaceous gland hyperplasias (pseudoadenomatoid) that distinguish it from an adenoma. Clinical records and photographs were critically reviewed and microscopic slides were stained with hematoxylin and eosin and immunochemically stained for adipophilin, androgen receptor, p16, p53, a spectrum of cytokeratins, Ki-67 and mismatch repair nuclear protein expression for MLH1, MSH2, PMS2, and MSH6. The patients and their close relatives had no history of cancer. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001497DOI Listing
October 2019
1 Read

CDKN2A, CDK1, and CCNE1 overexpression in sebaceous gland carcinoma of eyelid.

Int Ophthalmol 2020 Feb 30;40(2):343-350. Epub 2019 Sep 30.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Purpose: To investigate the overexpression of genes in sebaceous gland carcinoma (SGC) of the eyelid compared to sebaceous adenoma of the eyelid in order to elucidate the molecular mechanism underlying pathogenesis.

Methods: We performed histopathological examination of eyelid tissues surgically removed from four patients diagnosed with SGC (cases 1-3) and sebaceous adenoma (case 4) of the eyelid. Next, we performed global gene expression analysis of surgical tissue samples using a GeneChip system and the Ingenuity Pathways Knowledge Base. Read More

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http://link.springer.com/10.1007/s10792-019-01185-7
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http://dx.doi.org/10.1007/s10792-019-01185-7DOI Listing
February 2020
5 Reads

Pleomorphic adenoma: a rare presentation in buccal salivary gland with extensive squamous and mucous metaplasia.

Pan Afr Med J 2019 26;33:147. Epub 2019 Jun 26.

Department of Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.

Pleomorphic Adenoma (PA) is the most common salivary gland tumor and accounts for about 60% of all salivary gland neoplasms. Intraorally, the hard palate is the most common presenting site (50-60%) followed by upper lip (15-20%) and rarely buccal mucosa (8-10%). Histopathologically, PA shows diverse morphology resulting from amalgamation of cellular and stromal components. Read More

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http://dx.doi.org/10.11604/pamj.2019.33.147.17550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754833PMC
October 2019
5 Reads

Intraductal sebaceous papilloma of a meibomian gland: a new entity possibly associated with the MSH6 subtype of the Muir-Torre syndrome.

Surv Ophthalmol 2020 Mar - Apr;65(2):227-238. Epub 2019 Sep 23.

Department of Ophthalmic Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Over several months, a painless, multinodular, non-erythematous swelling of the deep tissues of his left upper eyelid developed in a 63-year-old man. An excisional biopsy with histopathologic evaluation disclosed a unique sebaceous papilloma within a cyst lined by non-keratinizing squamous epithelium that focally displayed a variably thick, superficial, eosinophilic cuticular layer. Immunohistochemical staining demonstrated that the tumor and its epithelial cystic lining had a profile consistent with Meibomian gland duct epithelium. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.09.002DOI Listing
September 2019
2 Reads

Sebaceous adenoma in the setting of immunosuppression for kidney transplantation.

JAAD Case Rep 2019 Sep 30;5(9):818-820. Epub 2019 Aug 30.

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jdcr.2019.07.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726862PMC
September 2019
2 Reads

Rare Huge Tubular Papillary Adenoma on the Buttock Demonstrated by Magnetic Resonance Imaging (MRI).

Am J Case Rep 2019 Aug 13;20:1195-1198. Epub 2019 Aug 13.

School of Medicine, National Defense Medical Center, Taipei, Taiwan.

BACKGROUND Tubular papillary adenoma is a rare eccrine-derivate dermal adnexal tumor, located in the scalp mostly. Earlier, the sebaceous cyst size was larger than 5 cm in diameter and may be confused with subcutaneous tumor. Cases of the tumor on the buttock with rapid growth are rare, therefore magnetic resonance imaging (MRI) may be helpful to determine their precise size, nature, and invasion of nearby organs for further confirmation. Read More

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http://dx.doi.org/10.12659/AJCR.916438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705341PMC
August 2019
5 Reads

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.

Adv Ther 2019 08 17;36(8):1950-1974. Epub 2019 Jun 17.

Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

Introduction: A vast increase in knowledge of numerous aspects of malignant salivary gland tumours has emerged during the last decade and, for several reasons, this has not been the case in benign epithelial salivary gland tumours. We have performed a literature review to investigate whether an accurate histological diagnosis of the 11 different types of benign epithelial salivary gland tumours is correlated to any differences in their clinical behaviour.

Methods: A search was performed for histological classifications, recurrence rates and risks for malignant transformation, treatment modalities, and prognosis of these tumours. Read More

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http://link.springer.com/10.1007/s12325-019-01007-3
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http://dx.doi.org/10.1007/s12325-019-01007-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822986PMC
August 2019
12 Reads
2.438 Impact Factor

Histopathological Findings of Intraoral Pleomorphic Adenomas: A Retrospective Study of a Case Series.

Int J Surg Pathol 2019 Oct 12;27(7):729-735. Epub 2019 Jun 12.

2 Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.

The aim of this study was to describe the clinicopathological features of 21 cases of intraoral pleomorphic adenoma (PA), with emphasis on histopathological findings. Between 2000 and 2016, all patients diagnosed as intraoral PA were retrieved and histopathological slides stained with hematoxylin and eosin reviewed to confirm the diagnosis. All tumors were classified histologically according to Seifert et al (1980). Read More

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http://dx.doi.org/10.1177/1066896919854181DOI Listing
October 2019
11 Reads

Tumor mutational signatures in sebaceous skin lesions from individuals with Lynch syndrome.

Mol Genet Genomic Med 2019 07 4;7(7):e00781. Epub 2019 Jun 4.

Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Vic., Australia.

Background: Muir-Torre syndrome is defined by the development of sebaceous skin lesions in individuals who carry a germline mismatch repair (MMR) gene mutation. Loss of expression of MMR proteins is frequently observed in sebaceous skin lesions, but MMR-deficiency alone is not diagnostic for carrying a germline MMR gene mutation.

Methods: Whole exome sequencing was performed on three MMR-deficient sebaceous lesions from individuals with MSH2 gene mutations (Lynch syndrome) and three MMR-proficient sebaceous lesions from individuals without Lynch syndrome with the aim of characterizing the tumor mutational signatures, somatic mutation burden, and microsatellite instability status. Read More

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http://dx.doi.org/10.1002/mgg3.781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625139PMC
July 2019
20 Reads

Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma.

J Cutan Pathol 2019 Oct 8;46(10):736-741. Epub 2019 Jul 8.

Department of Dermatology, University of California, San Francisco, San Francisco, California.

Background: Sebaceous carcinoma (SeC) is an uncommon malignancy arising from sebaceous glands of the conjunctiva and skin. Recurrent mutations in the ZNF750 were recently identified in ocular SeC. We assessed whether ZNF750 loss is a specific feature of ocular SeC or a general feature of sebaceous tumors. Read More

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http://dx.doi.org/10.1111/cup.13516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744339PMC
October 2019
12 Reads
1.560 Impact Factor

Syringocystadenoma papilliferum arising in a naevus sebaceous.

Malays J Pathol 2019 Apr;41(1):47-49

University of Malaya, Faculty of Medicine, Department of Medicine, Division of Dermatology, Kuala Lumpur, Malaysia.

Naevus sebaceus is a cutaneous hamartoma with the potential of developing into benign or malignant neoplasms. Syringocystadenoma papilliferum (SCAP) have been reported to originate from naevus sebaceus. SCAP is a rare, benign adnexal skin tumour of apocrine or eccrine type of differentiation which typically presents as a nodule or a plaque on the scalp or face. Read More

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April 2019
12 Reads

Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 07;43(7):984-994

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing
July 2019
27 Reads

Multiple benign adnexal tumours: Anything but benign.

Australas J Dermatol 2019 Aug 22;60(3):234-236. Epub 2019 Jan 22.

St Vincent's Hospital, Sydney, New South Wales, Australia.

Muir Torre syndrome is an autosomal dominant disorder characterised by germline mutations in mismatch repair genes involved in DNA repair, leading to microsatellite instability and a propensity to tumour formation. We report a case of a 67-year-old gentleman who underwent biopsy of a smooth nodular lesion on the nasal tip, histopathologically consistent with sebaceous adenoma. Immunohistochemistry suggested a loss of MSH6. Read More

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http://doi.wiley.com/10.1111/ajd.12989
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http://dx.doi.org/10.1111/ajd.12989DOI Listing
August 2019
49 Reads

Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors.

J Dermatol 2019 Mar 21;46(3):249-258. Epub 2019 Jan 21.

Institute for Hematopathology, Hamburg, Germany.

The histogenesis of extraocular sebaceous carcinomas is - in contrast to ocular sebaceous carcinomas - unclear, and information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce. This study attempts to elucidate the histogenesis of sebaceous tumors, using multicolor immunofluorescence stainings to analyze 21 cases of sebaceous tumors (six each of extraocular sebaceous carcinoma, sebaceous adenoma and sebaceoma, and three cases of steatocystomas) and eight cases of normal sebaceous glands for p63, several keratins, androgen receptor, adipophilin, epithelial membrane antigen (EMA) and Ki-67. The data of this observational study provide evidence for the existence of two subpopulations of progenitors in normal sebaceous glands: (i) p63 K5 progenitors which generate the K10 luminal cells of sebaceous ducts; and (ii) p63 K5 K7 progenitors which finally generate K7 adipophilin EMA sebocytes. Read More

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http://dx.doi.org/10.1111/1346-8138.14765DOI Listing
March 2019
20 Reads

An unusual case of tuberous sclerosis incidentally discovered in adulthood: case report and review of the literature.

Acta Radiol Open 2018 Dec 6;7(12):2058460118806328. Epub 2018 Dec 6.

Department of Advanced Biomedical Sciences, University "Federico II," Naples, Italy.

Tuberous sclerosis (TS) is a relatively rare multi-organ disorder generally diagnosed in infancy and described as a clinical triad of sebaceous adenoma, mental retardation, and seizures. Angiomyolipoma (AML) is the most common benign renal tumor usually found incidentally as a solitary small echogenic lesion on grayscale ultrasound. Less commonly, it is part of the TS complex and is seen as multiple lesions in both kidneys. Read More

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http://dx.doi.org/10.1177/2058460118806328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299912PMC
December 2018
15 Reads

Frequent TLE1 Expression in Cutaneous Neoplasms.

Am J Dermatopathol 2019 Jan;41(1):1-6

Dermatopathologist, Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

TLE1 immunohistochemistry is widely used as a biomarker for synovial sarcoma. Recently, we identified TLE1 expression in a subset of melanomas and noted staining in sebaceous glands and follicular epithelium. TLE1 immunohistochemistry has not been well studied in cutaneous tumors. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001186DOI Listing
January 2019
13 Reads

Multi-gene panel testing confirms phenotypic variability in MUTYH-Associated Polyposis.

Fam Cancer 2019 04;18(2):203-209

GeneDx, 207 Perry Parkway, Gaithersburg, MD, 20877, USA.

Biallelic pathogenic variants (PVs) in MUTYH cause MUTYH-Associated Polyposis (MAP), which displays phenotypic overlap with other hereditary colorectal cancer (CRC) syndromes including Familial Adenomatous Polyposis (FAP) and Lynch syndrome. We report the phenotypic spectrum of MAP in the context of multi-gene hereditary cancer panel testing. Genetic testing results and clinical histories were reviewed for individuals with biallelic MUTYH PVs detected by panel testing at a single commercial molecular diagnostic laboratory. Read More

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http://dx.doi.org/10.1007/s10689-018-00116-2DOI Listing
April 2019
8 Reads

Clinico-pathological predictors of mismatch repair deficiency in sebaceous neoplasia: A large case series from a single Australian private pathology service.

Australas J Dermatol 2019 May 2;60(2):126-133. Epub 2018 Dec 2.

Department of Clinical Pathology, Colorectal Oncogenomics Group, The University of Melbourne, Parkville, Victoria, Australia.

Background/objectives: Loss of expression of mismatch repair (MMR) proteins is frequently observed in sebaceous skin lesions and can be a herald for Lynch syndrome. The aim of this study was to identify clinico-pathological predictors of MMR deficiency in sebaceous neoplasia that could aid dermatologists and pathologists in determining which sebaceous lesions should undergo MMR immunohistochemistry (IHC).

Methods: An audit of sebaceous skin lesions (excluding hyperplasia) where pathologist-initiated MMR IHC was performed between January 2009 to December 2016 was undertaken from a single pathology practice identifying 928 lesions from 882 individuals. Read More

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http://doi.wiley.com/10.1111/ajd.12958
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http://dx.doi.org/10.1111/ajd.12958DOI Listing
May 2019
51 Reads

Cutaneous sebaceous tumours and Lynch syndrome: long-term follow-up of 60 patients.

Clin Exp Dermatol 2019 Jul 14;44(5):506-511. Epub 2018 Nov 14.

Department of Dermatology, Hospital Universitari de Bellvitge, IDIBELL, Universitat de Barcelona, Barcelona, Spain.

Background: Sebaceous neoplasms (SN) may appear sporadically in the general population but may also be part of the Muir-Torre variant of Lynch syndrome (MT-LS). There are few studies in southern Europe on the incidence of MT-LS in the population of patients with SN.

Aim: To retrospectively review patients with SN and to analyse their clinical features and the incidence of MT-LS. Read More

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http://dx.doi.org/10.1111/ced.13828DOI Listing
July 2019
6 Reads

СLINICAL AND LABORATORY CHARACTERISTICS OF PATIENTS WITH ADOLESCENCE ACNE AND ACNE TARDA.

Georgian Med News 2018 Sep(282):103-106

JSC "Astana Medical University", Kazakhstan.

Acne is a chronic recurrent androgen-mediated disease of the pilosebaceous complex with a multifactorial genetically determined development mechanism. Currently, there is a tendency to persistent course of the disease, resistance to therapy forms of acne, late debut and change the clinical picture of acne. This could be due to various factors, such as polycystic ovary syndrome, microadenoma and pituitary adenoma, congenital adrenal hyperplasia, SAHA syndrome, etc. Read More

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September 2018
13 Reads

Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous.

Clin Exp Dermatol 2019 Jun 25;44(4):438-440. Epub 2018 Sep 25.

Department of Dermatology and Sexually Transmitted Diseases, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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http://dx.doi.org/10.1111/ced.13753DOI Listing
June 2019
7 Reads
1.230 Impact Factor

Dermoscopy of Adnexal Tumors.

Dermatol Clin 2018 Oct 16;36(4):397-412. Epub 2018 Aug 16.

Dermatology Department, Hospital General Universitario de Alicante, ISABIAL, C/Maestro Alonso 109, 03010 Alicante, Spain.

Cutaneous adnexal tumors include lesions with apocrine, eccrine, follicular, sebaceous, and mixed differentiation. Most are benign and sporadic, although malignant forms are occasionally observed and some cases develop in the setting of inherited syndromes. These tumors often cause immense diagnostic difficulty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183107
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http://dx.doi.org/10.1016/j.det.2018.05.007DOI Listing
October 2018
67 Reads

[Dermatofibroma with sebaceous induction].

Ann Dermatol Venereol 2018 Oct 7;145(10):613-619. Epub 2018 Aug 7.

Cabinet de pathologie cutanée, 56, rue de la Roquette, 75011 Paris, France.

Background: Histiocytoma or dermatofibroma (DF) is a common benign skin tumour with several clinical and histopathological variants. Sebaceous induction overlying a dermatofibroma is rare and infrequently reported. Using a detailed clinical case, herein the semiological and dermoscopic features of this lesion are described and illustrated, and the differential diagnoses presented. Read More

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http://dx.doi.org/10.1016/j.annder.2018.04.011DOI Listing
October 2018
13 Reads

A rare case of hyaline cell-rich atypical chondroid syringoma with divergent differentiation.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):428-430

Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India.

Chondroid syringoma (CS) also known as mixed tumor of the skin, is a rare benign adnexal tumor accounting for < 0.098%. Epithelial cells arranged in cords and tubules set in myxoid or chondroid stroma. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_101_17DOI Listing
November 2018
20 Reads

Muir-Torre Syndrome: A Case Report in a Woman Without Personal Cancer History.

Am J Dermatopathol 2019 Jan;41(1):55-59

Departments of Dermatology, and.

We report a case of a 68-year-old white woman presenting with 5 sebaceous neoplasms, ranging from sebaceous adenoma to sebaceoma on histopathology. Despite the lack of a personal cancer history, her multiple sebaceous neoplasms and a paternal history of colon cancer prompted testing her sebaceous adenomas for microsatellite instability (MSI) by immunohistochemistry. The results showed retained nuclear expressions of MLH1 and PMS2 while MSH2 and MSH6 proteins were absent. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001210DOI Listing
January 2019
36 Reads

A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review.

Mol Med Rep 2018 Aug 5;18(2):1423-1432. Epub 2018 Jun 5.

Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China.

Familial adenomatous polyposis (FAP), an autosomal dominant disease, is a colon cancer predisposition syndrome that manifests as a large number of adenomatous polyps. Mutations in the Adenomatous polyposis coli (APC) gene are responsible for the majority of cases of FAP. The purpose of the present study was to report the clinical features of a Chinese family with FAP and screen for novel mutations using the targeted next‑generation sequencing technology. Read More

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http://dx.doi.org/10.3892/mmr.2018.9130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072187PMC
August 2018
33 Reads

Dermal duct tumour with ductal and sebaceous differentiation.

Australas J Dermatol 2018 Nov 13;59(4):e309-e310. Epub 2018 Jun 13.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/ajd.12853DOI Listing
November 2018
35 Reads

[A rare parotid tumor].

Ann Pathol 2018 Oct 5;38(5):321-324. Epub 2018 Jun 5.

Laboratoire d'anatomie et de cytologie pathologiques de l'hôpital Aristide-Le-Dantec, pavillon Bichat, avenue Pasteur, BP 3001, Dakar, Sénégal.

Introduction: Sebaceous lymphadenoma of the parotid (SLP) is a rare, benign tumor with similar epidemiological and macroscopic characteristics with other sebaceous differentiated tumors of the parotid (SDTP). The authors report a case of SLP in an 80-year-old woman. They then recall the distinctive histological and immunohistochemical criteria of SDTP. Read More

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http://dx.doi.org/10.1016/j.annpat.2018.04.005DOI Listing
October 2018
8 Reads

Desmoplastic Fibroma Recurrence Associated with Tuberous Sclerosis in a Young Patient.

Case Rep Dent 2018 18;2018:1370184. Epub 2018 Apr 18.

Advanced Education in General Dentistry, Master Degree Program at San Luis Potosi University, Faculty of Dentistry of San Luis Potosi, Universidad Autónoma de San Luis Potosí, San Luis Potosi, SLP, Mexico.

. A nine-year-old patient with a diagnosis of tuberous sclerosis (with no pathological record) that showed calcifications at the brain level. Besides, the case showed the Vogt triad (epilepsy, mental retardation, and sebaceous adenoma). Read More

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http://dx.doi.org/10.1155/2018/1370184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932521PMC
April 2018
4 Reads

Tumor Collision Over Sebaceous Nevus: Clues for Dermoscopic Diagnosis.

Actas Dermosifiliogr 2018 Sep 26;109(7):647-648. Epub 2018 May 26.

Unidad de Dermatología, Hospital del Mar, Barcelona, España.

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http://dx.doi.org/10.1016/j.ad.2017.04.034DOI Listing
September 2018
8 Reads

Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the Milan System for Reporting Salivary Gland Cytopathology.

Cancer Cytopathol 2018 07 18;126(7):490-497. Epub 2018 Apr 18.

Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona.

Background: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. Read More

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http://dx.doi.org/10.1002/cncy.22002DOI Listing
July 2018
16 Reads

Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection.

Appl Immunohistochem Mol Morphol 2019 09;27(8):584-588

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.

Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000664DOI Listing
September 2019
26 Reads

Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous.

Indian J Pathol Microbiol 2018 Jan-Mar;61(1):106-108

Department of Dermatology and Venerology, China-Japan Friendship Hospital, Beijing, China.

Nevus sebaceous (NS) is a clinically common benign tumor and has a high potential to develop into a great diversity of neoplasms of epidermal and adnexal origins. However, it is a rare phenomenon of the coexistence in a single NS with two or more skin tumors. We report a case of a 58-year-old woman with two kinds of neoplastic proliferation including syringocystadenoma papilliferum and trichoblastoma arising in NS on the scalp. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_613_16DOI Listing
November 2018
10 Reads

Electrochemotherapy with Bleomycin of Different types of Cutaneous Tumours in a Ferret (Mustela Putorius Furo).

Radiol Oncol 2018 Mar 7;52(1):98-104. Epub 2017 Dec 7.

Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.

Background: Mast cell tumour, sebaceous gland adenoma, and less common squamous papilloma are skin tumours in ferrets (), and early excisional surgery is usually the treatment of choice. The aim of our study was to investigate the effectiveness of electrochemotherapy (ECT), a new, minimally invasive non-surgical method, as first treatment option of different types of ferret skin tumours located on surgically difficult sites.

Materials And Methods: A 5-year-old castrated male ferret with two cutaneous masses, presenting 4 months apart and a 7-year-old spayed female ferret with two cutaneous masses, that appeared simultaneously on two locations are presented. Read More

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http://dx.doi.org/10.1515/raon-2017-0057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839087PMC
March 2018
19 Reads

Keratinizing pleomorphic adenoma: An unusual case report.

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S69-S72

Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.

Pleomorphic adenoma (PA) is the most common benign tumor of major or minor salivary glands. PA exhibits a great histological diversity, such as differentiation into oncocytic, sebaceous, mucinous, squamous, chondroid, osseous or adipose cells. Squamous metaplasia rarely results in the formation of extensive keratin-filled cyst lined by squamous epithelium. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_200_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824522PMC
January 2018
19 Reads

Unusual cystic lesion of the eyebrow: A case report of malignant chondroid syringoma.

J Stomatol Oral Maxillofac Surg 2018 Jun 22;119(3):232-235. Epub 2018 Feb 22.

Chirurgie maxillo-faciale, stomatologie, chirurgie orale et chirurgie plastique de la face, hospices civils de Lyon-université Claude-Bernard-Lyon 1, centre hospitalier Lyon-Sud, 165, chemin du Grand-Revoyet, 69310 Pierre-Bénite, France.

Introduction: Malignant chondroid syringomas, also known as cutaneous malignant mixed tumors, are rare neoplasms that most frequently occur on the torso or extremities of women. Here, we present an illustrated case of a facial malignant chondroid syringoma.

Materials And Methods: A 32-year-old female patient with no notable medical history presented with an approximately 1cm-wide, painless, palpably-mobile subcutaneous nodule, suggestive of a sebaceous cyst, just above the middle third of the right eyebrow. Read More

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http://dx.doi.org/10.1016/j.jormas.2018.02.008DOI Listing
June 2018
9 Reads

Evaluation of universal immunohistochemical screening of sebaceous neoplasms in a service setting.

Clin Exp Dermatol 2018 Jun 14;43(4):410-415. Epub 2018 Jan 14.

East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Background: Muir-Torre syndrome (MTS) is a subtype of Lynch syndrome, which encompasses the combination of sebaceous skin tumours or keratoacanthomas and internal malignancy, due to mutations in DNA mismatch repair genes. Sebaceous neoplasms (SNs) may occur before other malignancies, and may lead to the diagnosis, which allows testing of other family members, cancer surveillance, risk-reducing surgery or prevention therapies.

Aim: To evaluate the efficacy of universal immunohistochemistry (IHC) screening of SNs in a service setting. Read More

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http://dx.doi.org/10.1111/ced.13359DOI Listing
June 2018
13 Reads

Sebaceous tumours: more than skin deep.

Gut 2018 11 15;67(11):1957. Epub 2017 Dec 15.

Department of Dermatology Venerology and Allergology, University Hospital Essen, Essen, Germany.

CLINICAL PRESENTATION: A 77-year-old man presented to our skin cancer centre with various cutaneous tumours occurring in 2006-2017. Histopathology showed a 'hidradenocarcinoma' on the left upper back (2006) and a sebaceous adenoma (figure 1) on the left shoulder (2011). In 2017, he developed a sebaceous carcinoma on the middle upper back, which manifested as a slowly enlarging, asymptomatic nodule. Read More

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-315472
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http://dx.doi.org/10.1136/gutjnl-2017-315472DOI Listing
November 2018
46 Reads

Primary orbital apocrine hidrocystoma with sebaceous elements.

Clin Exp Ophthalmol 2018 07 28;46(5):560-562. Epub 2017 Dec 28.

South Australian Institute of Ophthalmology, Royal Adelaide Hospital, University of Adelaide, Australia.

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http://doi.wiley.com/10.1111/ceo.13122
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http://dx.doi.org/10.1111/ceo.13122DOI Listing
July 2018
27 Reads

Intra-oral Sebaceous Gland Tumours in Two Dogs.

J Comp Pathol 2017 Nov 7;157(4):296-298. Epub 2017 Nov 7.

Department of Veterinary Pathology and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address:

A 12-year-old female miniature schnauzer and a 12-year-old neutered female cocker spaniel each had a grey-yellow nodular lesion arising from the gingiva. Microscopical examination showed that both nodules were composed of varied proportions of sebocytes and basal-type reserve cells with few ducts lined by stratified squamous epithelium. Based on the histopathological findings, the cases were diagnosed as sebaceous adenoma and sebaceous epithelioma, respectively. Read More

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http://dx.doi.org/10.1016/j.jcpa.2017.10.003DOI Listing
November 2017
10 Reads

Syringocystadenoma papilliferum combined with a tubular apocrine adenoma.

An Bras Dermatol 2017 Sep-Oct;92(5):721-723

Dermatopathology Service at the Hospital Universitário Professor Alberto Antunes - Universidade Federal de Alagoas (HUPAA-UFAL) - Maceió (AL), Brazil.

Syringocystadenoma papilliferum and tubular apocrine adenoma are rare benign sweat gland tumors. Syringocystadenoma papilliferum occurs alone or in association with other tumors. Although it is rare, the association of tubular apocrine adenoma with syringocystadenoma papilliferum developing in a sebaceous nevus on the scalp is well documented. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/abd1806-4841.20174580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674711PMC
February 2018
19 Reads

Holocrine Poroma: A Distinctive Adnexal Tumor.

Am J Dermatopathol 2018 Jun;40(6):401-408

Department of Pathology, Montefiore Medical Center, Bronx, NY.

There are 36 cases of complex poroid tumors with folliculosebaceous and apocrine differentiation reported in the literature. The authors evaluated 111 poroid tumors including 63 typical eccrine poromas and 48 poroid tumors with folliculosebaceous elements. Folliculosebaceous poroid tumors (FSPT) had basaloid and squamous cells (100%), ducts with steatocystoma-like cuticles and holocrine secretions (89. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001046DOI Listing
June 2018
18 Reads