747 results match your criteria Sebaceous Adenoma


Multiple benign adnexal tumours: Anything but benign.

Australas J Dermatol 2019 Jan 22. Epub 2019 Jan 22.

St Vincent's Hospital, Sydney, New South Wales, Australia.

Muir Torre syndrome is an autosomal dominant disorder characterised by germline mutations in mismatch repair genes involved in DNA repair, leading to microsatellite instability and a propensity to tumour formation. We report a case of a 67-year-old gentleman who underwent biopsy of a smooth nodular lesion on the nasal tip, histopathologically consistent with sebaceous adenoma. Immunohistochemistry suggested a loss of MSH6. Read More

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http://doi.wiley.com/10.1111/ajd.12989
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http://dx.doi.org/10.1111/ajd.12989DOI Listing
January 2019
6 Reads

Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors.

J Dermatol 2019 Jan 21. Epub 2019 Jan 21.

Institute for Hematopathology, Hamburg, Germany.

The histogenesis of extraocular sebaceous carcinomas is - in contrast to ocular sebaceous carcinomas - unclear, and information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce. This study attempts to elucidate the histogenesis of sebaceous tumors, using multicolor immunofluorescence stainings to analyze 21 cases of sebaceous tumors (six each of extraocular sebaceous carcinoma, sebaceous adenoma and sebaceoma, and three cases of steatocystomas) and eight cases of normal sebaceous glands for p63, several keratins, androgen receptor, adipophilin, epithelial membrane antigen (EMA) and Ki-67. The data of this observational study provide evidence for the existence of two subpopulations of progenitors in normal sebaceous glands: (i) p63 K5 progenitors which generate the K10 luminal cells of sebaceous ducts; and (ii) p63 K5 K7 progenitors which finally generate K7 adipophilin EMA sebocytes. Read More

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http://dx.doi.org/10.1111/1346-8138.14765DOI Listing
January 2019
2 Reads

An unusual case of tuberous sclerosis incidentally discovered in adulthood: case report and review of the literature.

Acta Radiol Open 2018 Dec 6;7(12):2058460118806328. Epub 2018 Dec 6.

Department of Advanced Biomedical Sciences, University "Federico II," Naples, Italy.

Tuberous sclerosis (TS) is a relatively rare multi-organ disorder generally diagnosed in infancy and described as a clinical triad of sebaceous adenoma, mental retardation, and seizures. Angiomyolipoma (AML) is the most common benign renal tumor usually found incidentally as a solitary small echogenic lesion on grayscale ultrasound. Less commonly, it is part of the TS complex and is seen as multiple lesions in both kidneys. Read More

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http://dx.doi.org/10.1177/2058460118806328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299912PMC
December 2018
2 Reads

Frequent TLE1 Expression in Cutaneous Neoplasms.

Am J Dermatopathol 2019 Jan;41(1):1-6

Dermatopathologist, Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

TLE1 immunohistochemistry is widely used as a biomarker for synovial sarcoma. Recently, we identified TLE1 expression in a subset of melanomas and noted staining in sebaceous glands and follicular epithelium. TLE1 immunohistochemistry has not been well studied in cutaneous tumors. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001186DOI Listing
January 2019
2 Reads

Clinico-pathological predictors of mismatch repair deficiency in sebaceous neoplasia: A large case series from a single Australian private pathology service.

Australas J Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Clinical Pathology, Colorectal Oncogenomics Group, The University of Melbourne, Parkville, Victoria, Australia.

Background/objectives: Loss of expression of mismatch repair (MMR) proteins is frequently observed in sebaceous skin lesions and can be a herald for Lynch syndrome. The aim of this study was to identify clinico-pathological predictors of MMR deficiency in sebaceous neoplasia that could aid dermatologists and pathologists in determining which sebaceous lesions should undergo MMR immunohistochemistry (IHC).

Methods: An audit of sebaceous skin lesions (excluding hyperplasia) where pathologist-initiated MMR IHC was performed between January 2009 to December 2016 was undertaken from a single pathology practice identifying 928 lesions from 882 individuals. Read More

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http://doi.wiley.com/10.1111/ajd.12958
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http://dx.doi.org/10.1111/ajd.12958DOI Listing
December 2018
12 Reads

СLINICAL AND LABORATORY CHARACTERISTICS OF PATIENTS WITH ADOLESCENCE ACNE AND ACNE TARDA.

Georgian Med News 2018 Sep(282):103-106

JSC "Astana Medical University", Kazakhstan.

Acne is a chronic recurrent androgen-mediated disease of the pilosebaceous complex with a multifactorial genetically determined development mechanism. Currently, there is a tendency to persistent course of the disease, resistance to therapy forms of acne, late debut and change the clinical picture of acne. This could be due to various factors, such as polycystic ovary syndrome, microadenoma and pituitary adenoma, congenital adrenal hyperplasia, SAHA syndrome, etc. Read More

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September 2018
2 Reads

Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous.

Clin Exp Dermatol 2018 Sep 25. Epub 2018 Sep 25.

Department of Dermatology and Sexually Transmitted Diseases, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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http://dx.doi.org/10.1111/ced.13753DOI Listing
September 2018
1 Read
1.230 Impact Factor

Dermoscopy of Adnexal Tumors.

Dermatol Clin 2018 Oct 16;36(4):397-412. Epub 2018 Aug 16.

Dermatology Department, Hospital General Universitario de Alicante, ISABIAL, C/Maestro Alonso 109, 03010 Alicante, Spain.

Cutaneous adnexal tumors include lesions with apocrine, eccrine, follicular, sebaceous, and mixed differentiation. Most are benign and sporadic, although malignant forms are occasionally observed and some cases develop in the setting of inherited syndromes. These tumors often cause immense diagnostic difficulty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183107
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http://dx.doi.org/10.1016/j.det.2018.05.007DOI Listing
October 2018
13 Reads

A rare case of hyaline cell-rich atypical chondroid syringoma with divergent differentiation.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):428-430

Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India.

Chondroid syringoma (CS) also known as mixed tumor of the skin, is a rare benign adnexal tumor accounting for < 0.098%. Epithelial cells arranged in cords and tubules set in myxoid or chondroid stroma. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_101_17DOI Listing
November 2018
10 Reads

Muir-Torre Syndrome: A Case Report in a Woman Without Personal Cancer History.

Am J Dermatopathol 2019 Jan;41(1):55-59

Departments of Dermatology, and.

We report a case of a 68-year-old white woman presenting with 5 sebaceous neoplasms, ranging from sebaceous adenoma to sebaceoma on histopathology. Despite the lack of a personal cancer history, her multiple sebaceous neoplasms and a paternal history of colon cancer prompted testing her sebaceous adenomas for microsatellite instability (MSI) by immunohistochemistry. The results showed retained nuclear expressions of MLH1 and PMS2 while MSH2 and MSH6 proteins were absent. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001210DOI Listing
January 2019
11 Reads

A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review.

Mol Med Rep 2018 Aug 5;18(2):1423-1432. Epub 2018 Jun 5.

Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China.

Familial adenomatous polyposis (FAP), an autosomal dominant disease, is a colon cancer predisposition syndrome that manifests as a large number of adenomatous polyps. Mutations in the Adenomatous polyposis coli (APC) gene are responsible for the majority of cases of FAP. The purpose of the present study was to report the clinical features of a Chinese family with FAP and screen for novel mutations using the targeted next‑generation sequencing technology. Read More

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http://dx.doi.org/10.3892/mmr.2018.9130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072187PMC
August 2018
3 Reads

Desmoplastic Fibroma Recurrence Associated with Tuberous Sclerosis in a Young Patient.

Case Rep Dent 2018 18;2018:1370184. Epub 2018 Apr 18.

Advanced Education in General Dentistry, Master Degree Program at San Luis Potosi University, Faculty of Dentistry of San Luis Potosi, Universidad Autónoma de San Luis Potosí, San Luis Potosi, SLP, Mexico.

. A nine-year-old patient with a diagnosis of tuberous sclerosis (with no pathological record) that showed calcifications at the brain level. Besides, the case showed the Vogt triad (epilepsy, mental retardation, and sebaceous adenoma). Read More

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http://dx.doi.org/10.1155/2018/1370184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932521PMC

Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the Milan System for Reporting Salivary Gland Cytopathology.

Cancer Cytopathol 2018 Jul 18;126(7):490-497. Epub 2018 Apr 18.

Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona.

Background: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. Read More

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http://dx.doi.org/10.1002/cncy.22002DOI Listing
July 2018
7 Reads

Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection.

Appl Immunohistochem Mol Morphol 2018 Apr 7. Epub 2018 Apr 7.

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.

Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000664DOI Listing
April 2018
4 Reads

Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous.

Indian J Pathol Microbiol 2018 Jan-Mar;61(1):106-108

Department of Dermatology and Venerology, China-Japan Friendship Hospital, Beijing, China.

Nevus sebaceous (NS) is a clinically common benign tumor and has a high potential to develop into a great diversity of neoplasms of epidermal and adnexal origins. However, it is a rare phenomenon of the coexistence in a single NS with two or more skin tumors. We report a case of a 58-year-old woman with two kinds of neoplastic proliferation including syringocystadenoma papilliferum and trichoblastoma arising in NS on the scalp. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_613_16DOI Listing
November 2018

Electrochemotherapy with Bleomycin of Different types of Cutaneous Tumours in a Ferret (Mustela Putorius Furo).

Radiol Oncol 2018 Mar 7;52(1):98-104. Epub 2017 Dec 7.

Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.

Background: Mast cell tumour, sebaceous gland adenoma, and less common squamous papilloma are skin tumours in ferrets (), and early excisional surgery is usually the treatment of choice. The aim of our study was to investigate the effectiveness of electrochemotherapy (ECT), a new, minimally invasive non-surgical method, as first treatment option of different types of ferret skin tumours located on surgically difficult sites.

Materials And Methods: A 5-year-old castrated male ferret with two cutaneous masses, presenting 4 months apart and a 7-year-old spayed female ferret with two cutaneous masses, that appeared simultaneously on two locations are presented. Read More

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http://dx.doi.org/10.1515/raon-2017-0057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839087PMC
March 2018
10 Reads

Keratinizing pleomorphic adenoma: An unusual case report.

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S69-S72

Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.

Pleomorphic adenoma (PA) is the most common benign tumor of major or minor salivary glands. PA exhibits a great histological diversity, such as differentiation into oncocytic, sebaceous, mucinous, squamous, chondroid, osseous or adipose cells. Squamous metaplasia rarely results in the formation of extensive keratin-filled cyst lined by squamous epithelium. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_200_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824522PMC
January 2018
2 Reads

Evaluation of universal immunohistochemical screening of sebaceous neoplasms in a service setting.

Clin Exp Dermatol 2018 Jun 14;43(4):410-415. Epub 2018 Jan 14.

East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Background: Muir-Torre syndrome (MTS) is a subtype of Lynch syndrome, which encompasses the combination of sebaceous skin tumours or keratoacanthomas and internal malignancy, due to mutations in DNA mismatch repair genes. Sebaceous neoplasms (SNs) may occur before other malignancies, and may lead to the diagnosis, which allows testing of other family members, cancer surveillance, risk-reducing surgery or prevention therapies.

Aim: To evaluate the efficacy of universal immunohistochemistry (IHC) screening of SNs in a service setting. Read More

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http://dx.doi.org/10.1111/ced.13359DOI Listing
June 2018
3 Reads

Sebaceous tumours: more than skin deep.

Gut 2018 11 15;67(11):1957. Epub 2017 Dec 15.

Department of Dermatology Venerology and Allergology, University Hospital Essen, Essen, Germany.

CLINICAL PRESENTATION: A 77-year-old man presented to our skin cancer centre with various cutaneous tumours occurring in 2006-2017. Histopathology showed a 'hidradenocarcinoma' on the left upper back (2006) and a sebaceous adenoma (figure 1) on the left shoulder (2011). In 2017, he developed a sebaceous carcinoma on the middle upper back, which manifested as a slowly enlarging, asymptomatic nodule. Read More

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-315472
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http://dx.doi.org/10.1136/gutjnl-2017-315472DOI Listing
November 2018
19 Reads

Intra-oral Sebaceous Gland Tumours in Two Dogs.

J Comp Pathol 2017 Nov 7;157(4):296-298. Epub 2017 Nov 7.

Department of Veterinary Pathology and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address:

A 12-year-old female miniature schnauzer and a 12-year-old neutered female cocker spaniel each had a grey-yellow nodular lesion arising from the gingiva. Microscopical examination showed that both nodules were composed of varied proportions of sebocytes and basal-type reserve cells with few ducts lined by stratified squamous epithelium. Based on the histopathological findings, the cases were diagnosed as sebaceous adenoma and sebaceous epithelioma, respectively. Read More

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http://dx.doi.org/10.1016/j.jcpa.2017.10.003DOI Listing
November 2017
3 Reads

Syringocystadenoma papilliferum combined with a tubular apocrine adenoma.

An Bras Dermatol 2017 Sep-Oct;92(5):721-723

Dermatopathology Service at the Hospital Universitário Professor Alberto Antunes - Universidade Federal de Alagoas (HUPAA-UFAL) - Maceió (AL), Brazil.

Syringocystadenoma papilliferum and tubular apocrine adenoma are rare benign sweat gland tumors. Syringocystadenoma papilliferum occurs alone or in association with other tumors. Although it is rare, the association of tubular apocrine adenoma with syringocystadenoma papilliferum developing in a sebaceous nevus on the scalp is well documented. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/abd1806-4841.20174580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674711PMC
February 2018
9 Reads

Holocrine Poroma: A Distinctive Adnexal Tumor.

Am J Dermatopathol 2018 Jun;40(6):401-408

Department of Pathology, Montefiore Medical Center, Bronx, NY.

There are 36 cases of complex poroid tumors with folliculosebaceous and apocrine differentiation reported in the literature. The authors evaluated 111 poroid tumors including 63 typical eccrine poromas and 48 poroid tumors with folliculosebaceous elements. Folliculosebaceous poroid tumors (FSPT) had basaloid and squamous cells (100%), ducts with steatocystoma-like cuticles and holocrine secretions (89. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001046DOI Listing
June 2018
9 Reads

Reticulated acanthoma with sebaceous differentiation mimicking melanoma.

Dermatol Pract Concept 2017 Jul 31;7(3):35-37. Epub 2017 Jul 31.

Department of Dermatology, Mogi das Cruzes University, Mogi das Cruzes, Brazil.

Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. Read More

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http://dx.doi.org/10.5826/dpc.0703a07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661163PMC
July 2017
5 Reads

Sebaceous lesions of the skin.

Pathology 2017 Dec 25;49(7):688-697. Epub 2017 Oct 25.

Dermatopathology Group, Department of Anatomical Pathology, PathWest, Perth, Australia; School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia. Electronic address:

Sebaceous differentiation is commonly seen in cutaneous neoplasms, both in the context of lesions showing predominantly sebaceous differentiation (e.g., sebaceous adenoma, sebaceoma and sebaceous carcinoma), or as more focal sebaceous components in neoplasms with other primary lines of differentiation. Read More

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http://dx.doi.org/10.1016/j.pathol.2017.08.012DOI Listing
December 2017
11 Reads

Spectrum of Hybrid Cysts and Their Clinical Significance.

Am J Dermatopathol 2018 Jun;40(6):397-400

Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.

A hybrid cyst is a cutaneous cyst combining different types of keratinization of those seen in the folliculo-sebaceous-apocrine unit. Previous reports found that it may be occasionally associated with Gardner syndrome. This study aimed to clarify the pathologic findings and clinical significance of hybrid cyst based on case series observations. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001006DOI Listing
June 2018
8 Reads

Evaluation and comparison of staining patterns of factor XIIIa (AC-1A1), adipophilin and GATA3 in sebaceous neoplasia.

J Cutan Pathol 2018 Jan 19;45(1):1-7. Epub 2017 Sep 19.

Department of Pathology, University of South Dakota, Sanford School of Medicine, Sioux Falls, South Dakota.

Background: Reliable nuclear immunohistochemical stains for sebaceous neoplasms have not been readily available. Positive nuclear staining has been reported for GATA3 and factor XIIIa (AC-1A1). We sought to determine the diagnostic utility of these nuclear stains by comparing their staining pattern to adipophilin, a consistently positive cytoplasmic stain. Read More

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http://dx.doi.org/10.1111/cup.13037DOI Listing
January 2018
12 Reads

TdT expression in normal and neoplastic sebaceous cells.

Histopathology 2017 Dec 19;71(6):985-988. Epub 2017 Sep 19.

Pathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Aims: Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase expressed in immature, normal and neoplastic, lymphoid or haematopoietic cells and in neuroendocrine carcinomas, such as Merkel cell carcinoma and small-cell carcinoma. It has not yet been described in cells of epithelial origin. After observing TdT immunoreactivity in normal sebaceous glands, we analysed its spectrum of expression in cases of sebaceous cell hyperplasia (SGH) and sebaceous cell neoplasm. Read More

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http://dx.doi.org/10.1111/his.13304DOI Listing
December 2017
51 Reads

Mucoepidermoid Carcinoma of Salivary Gland: Limitations and Pitfalls on FNA.

J Clin Diagn Res 2017 May 1;11(5):ER04-ER06. Epub 2017 May 1.

Junior Resident, Department of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

Mucoepidermoid Carcinoma (MEC) is the most common malignant neoplasm of salivary gland origin. However, its morphologic heterogeneity poses difficulty in interpretation. In the present series we discuss the morphologic features of MEC, limitations and pitfalls in its diagnosis on Fine Needle Aspiration Cytology (FNAC). Read More

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http://dx.doi.org/10.7860/JCDR/2017/25341.9941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483695PMC
May 2017
24 Reads

High-energy particle beam and gamma radiation exposure, familial relatedness and cancer in mice.

Br J Cancer 2017 Jun 23;117(1):41-50. Epub 2017 May 23.

Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-9778, USA.

Background: Some highly penetrant familial cancer syndromes exhibit elevated leukaemia risk, and there is evidence for familial clustering of lung cancer and other common cancers. Lung cancer and leukaemia are strongly radiogenic, but there are few indications that high-energy beam irradiation is markedly more effective than lower-energy radiation.

Methods: We used a Cox model with familially structured random effects to assess 16 mortality end points in a group of 1850 mice in 47 families maintained in a circular-breeding scheme, exposed to accelerated Si or Fe ions (0. Read More

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http://dx.doi.org/10.1038/bjc.2017.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520205PMC
June 2017
25 Reads

A case report of Muir-Torre syndrome in a woman with breast cancer and MSI-Low skin squamous cell carcinoma.

Hered Cancer Clin Pract 2017 12;15. Epub 2017 May 12.

Department of Genetics, Hôpital Nord, CHU Saint Etienne, 42055 Saint-Etienne Cedex 2, France.

Background: The tumor spectrum in the Lynch syndrome is well defined, comprising an increased risk of developing colonic and extracolonic malignancies. Muir-Torre syndrome is a variant with a higher risk of skin disease. Patients have been described carrying mutations in the mismatch repair genes and presenting tumors with unusual histology or affected organ not part of the Lynch syndrome spectrum. Read More

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http://dx.doi.org/10.1186/s13053-017-0066-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429559PMC
May 2017
39 Reads

A Case of Syringocystadenoma Papilliferum with Tubular Papillary Adenoma of the Chest.

J Nippon Med Sch 2017 ;84(2):79-82

Department of Dermatology, Nippon Medical School.

We report a case of syringocystadenoma papilliferum (SCAP) combined with tubular papillary adenoma (TPA) arising on the chest of a 45-year-old Japanese woman. Histopathological examination revealed the characteristic findings of SCAP in the superficial part of the lesion and those of TPA in the deeper part. We reviewed the English literature about this combination. Read More

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http://dx.doi.org/10.1272/jnms.84.79DOI Listing
September 2017
20 Reads

Syringocystadenoma Papilliferum of the External Auditory Canal.

Am J Case Rep 2017 May 11;18:520-524. Epub 2017 May 11.

Ear, Nose, Throat (ENT) Audiology and Phoniatry Unit, University Hospital of Pisa, Pisa, Italy.

BACKGROUND Ceruminous glands are modified apocrine glands, situated in the external auditory canal, that, together with sebaceous glands, produce cerumen, better known as ear wax. The neoplastic transformation of these structures is very rare and there have been few cases reported in the literature. CASE REPORT Syringocystadenoma papilliferum is one of the rarest tumors among benign tumors arising from the ceruminous glands. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434769PMC
May 2017
4 Reads

Sebaceous Neoplasms.

Authors:
Katharina Flux

Surg Pathol Clin 2017 Jun;10(2):367-382

Department of Dermatology, University of Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany; Labor für Dermatohistologie und Oralpathologie, Bayerstrasse 69, 80335 München, Munich, Germany. Electronic address:

Sebaceous skin tumors are classified into sebaceous adenoma, sebaceoma, and sebaceous carcinoma. An additional group of cystic sebaceous tumors indicate the Muir-Torre syndrome (MTS). Cystic sebaceous tumors are considered as morphologic variants of the 3 main categories. Read More

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http://dx.doi.org/10.1016/j.path.2017.01.009DOI Listing
June 2017
14 Reads

MSH6, Past and Present and Muir-Torre Syndrome-Connecting the Dots.

Authors:
Meera Mahalingam

Am J Dermatopathol 2017 Apr;39(4):239-249

Dermatopathology Section Chief, Dermatopathology Section, Department of Pathology and Laboratory Medicine (113), VA Consolidated Laboratories, West Roxbury, MA.

Sebaceous neoplasms such as adenoma, sebaceoma, and carcinoma, although sporadic in their occurrence, are clinically significant because of their association with Muir-Torre syndrome (MTS). MTS is a rare autosomal dominant genodermatosis characterized by the occurrence of sebaceous neoplasms and/or keratoacanthomas and visceral malignancies. MTS is usually the result of germline mutations in the DNA mismatch repair genes MSH2 and, albeit less commonly, MLH1. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000633DOI Listing
April 2017
4 Reads

Sebaceous adenoma arising in mature cystic teratoma of the ovary. Case report.

Cesk Patol 2017 ;53(1):35-37

We report the case of a 44-year-old female with sebaceous adenoma arising in mature cystic teratoma of the ovary. The patient had a tumor in the left ovary; 125 x 90 x 70 mm. Microscopically, the tumor consisted of structures typical of dermoid cysts. Read More

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January 2017
9 Reads

Muir-Torre syndrome caused by exonic deletion of MLH1 due to homologous recombination.

Eur J Dermatol 2017 Feb;27(1):54-58

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Background: Muir-Torre syndrome (MTS) is characterized by sebaceous neoplasms with internal malignancies and regarded as a variant of hereditary nonpolyposis colorectal cancer (HNPCC). Pathogenic variations of MTS have been identified in the MSH2, MLH1, and MSH6 genes, with the majority of variations located in MSH2.

Objectives: To present an MTS patient who was the only individual with skin malignancies within a cancer-prone pedigree and to show the usefulness of RNA-based genetic analysis in the investigation of MTS. Read More

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http://dx.doi.org/10.1684/ejd.2016.2916DOI Listing
February 2017
15 Reads

Identification of MSH2 inversion of exons 1-7 in clinical evaluation of families with suspected Lynch syndrome.

Fam Cancer 2017 07;16(3):357-361

Clinical Cancer Genetics Program, UT MD Anderson Center, Unit 1354, 1155 Pressler St., Houston, TX, 77030, USA.

Traditional germline sequencing and deletion/duplication analysis does not detect Lynch syndrome-causing mutations in all individuals whose colorectal or endometrial tumors demonstrate mismatch repair (MMR) deficiency. Unique inversions and other rearrangements of the MMR genes have been reported in families with Lynch syndrome. In 2014, a recurrent inversion of MSH2 exons 1-7 was identified in five families suspected to have Lynch syndrome. Read More

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http://dx.doi.org/10.1007/s10689-016-9960-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479758PMC
July 2017
22 Reads

Cutaneous Sebaceous Lesions in a Patient With MUTYH-Associated Polyposis Mimicking Muir-Torre Syndrome.

Am J Dermatopathol 2016 Dec;38(12):915-923

*Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Prague, Czech Republic; †Bioptical Laboratory, Pilsen, Czech Republic; and ‡Department of Dermatology, Regional Hospital, Sumperk, Czech Republic.

A 76-year-old white male with a history of adenocarcinoma of the rectosigmoideum and multiple colonic polyps removed at the age of 38 and 39 years by an abdominoperitoneal amputation and total colectomy, respectively, presented with multiple whitish and yellowish papules on the face and a verrucous lesion on the trunk. The lesions were surgically removed during the next 3 years and a total of 13 lesions were investigated histologically. The diagnoses included 11 sebaceous adenomas, 1 low-grade sebaceous carcinoma, and 1 squamous cell carcinoma. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000649DOI Listing
December 2016
32 Reads

Sebaceous hyperplasia and sebaceous adenomas presenting as leonine facies and improving with oral isotretinoin.

Clin Exp Dermatol 2016 Dec 19;41(8):923-924. Epub 2016 Oct 19.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

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http://doi.wiley.com/10.1111/ced.12918
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http://dx.doi.org/10.1111/ced.12918DOI Listing
December 2016
13 Reads

Unusual Presentation of Ulcerative Postauricular Swelling as Sebaceous Cell Carcinoma.

Niger J Surg 2016 Jul-Dec;22(2):127-129

Department of General Surgery, Government Medical College, Patiala, Punjab, India.

Sebaceous glands have high concentration over head and neck region. Despite high concentration, sebaceous cell adenoma and carcinomas are infrequent. Sebaceous cell carcinoma is an uncommon, cutaneous aggressive tumor arising from the sebaceous glands and seen almost exclusively on the eyelids (75%). Read More

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http://dx.doi.org/10.4103/1117-6806.169819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013740PMC
November 2016
10 Reads

Clinicopathological study of 47 cases of sebaceoma.

Ann Dermatol Venereol 2016 Dec 9;143(12):814-824. Epub 2016 Nov 9.

Clinique dermatologique, faculté de médecine, université de Strasbourg, hôpitaux universitaires de Strasbourg, hôpital civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.

Background: Sebaceoma is a rare and poorly understood form of sebaceous tumour, and it is of great significance since it may reveal Muir-Torre syndrome (MTS). Herein, we present a series of cases with details of the histopathological appearance.

Patients And Methods: We examined records of cases labelled as sebaceous tumour recorded at the Strasbourg Dermatopathology Laboratory between 1991 and 2015. Read More

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http://dx.doi.org/10.1016/j.annder.2016.06.013DOI Listing
December 2016
32 Reads

[Muir-Torre syndrome associated with Waldenstrom's macroglobulinemia].

Ann Dermatol Venereol 2016 Dec 19;143(12):825-830. Epub 2016 Oct 19.

Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67000 Strasbourg, France.

Background: Muir-Torre syndrome (MTS), a cutaneous variant of Lynch syndrome, consists of hereditary predisposition to cutaneous tumours and gastrointestinal and gynaecological neoplasms, with autosomal dominant transmission. It is associated with mutations in genes coding for proteins in the DNA mismatch repair system.

Patients And Methods: Herein, we report a case of a male patient presenting Waldenstrom's macroglobulinemia since the age of 50 and which, after the age of 65 years, developed into sebaceous tumours (5 sebaceous adenomas, 1 sebaceoma, 1 sebaceous carcinoma) and colonic lesions (4 adenomas). Read More

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http://dx.doi.org/10.1016/j.annder.2016.09.040DOI Listing
December 2016
4 Reads

Sebaceous adenomas in the absence of Muir-Torre syndrome.

Can J Ophthalmol 2016 Oct 31;51(5):e152-e153. Epub 2016 Aug 31.

Royal Adelaide Hospital, Adelaide, Australia; University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1016/j.jcjo.2016.05.006DOI Listing
October 2016
6 Reads

Sebaceous mantleoma (mantle adenoma): reappraisal of the myth of the problematic benign neoplasm with sebaceous mantle differentiation.

J Cutan Pathol 2016 Nov 1;43(11):1050-1055. Epub 2016 Sep 1.

Department of Pathology, Itabashi Central Medical Laboratory, Tokyo, Japan.

Few cases of a true benign neoplasm with sebaceous mantle differentiation have been reported, and little is known about this tumor. Herein, we present a rare case of the neoplasm called sebaceous mantleoma, along with a comparison of the histology and immunoprofile with those of normal sebaceous mantles. A pedunculated polyp occurred on the scalp of a 51-year-old woman. Read More

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http://dx.doi.org/10.1111/cup.12789DOI Listing
November 2016
5 Reads

Enlightening the Pink: Use of Confocal Microscopy in Pink Lesions.

Dermatol Clin 2016 Oct;34(4):443-458

Medicine and Medical Specialities Department, Medicine and Health Sciences Faculty, Alcalá University, Univeristy Campus, National road II, 28871- Alcalá de Henares, Madrid, Spain; Dermatology Service, Memorial Sloan-Kettering Cancer Center, 16 E 60th Street, New York, NY 10022, USA.

Solitary pink lesions can pose a particular challenge to dermatologists because they may be almost or completely featureless clinically and dermoscopically, previously requiring biopsy to exclude malignancy. However, these lesions usually are not particularly challenging histopathologically. Thus, the incorporation of in vivo reflectance confocal microscopy into the clinical practice, which allows for noninvasive examination of the skin at the cellular level revealing features previously seen only on histopathology, is particularly useful for this subset of clinically difficult lesions. Read More

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http://dx.doi.org/10.1016/j.det.2016.05.007DOI Listing
October 2016
11 Reads

A unique case of isolated sebaceous adenoma of the bulbar conjunctiva.

Arq Bras Oftalmol 2016 Jul-Aug;79(4):253-4

Department of Ophthalmology, Akdeniz University, Antalya, Turkey.

Our patient was a 34 year-old male who presented with a painless conjunctival mass that had developed 3 months before his first visit. On performing slit-lamp biomicroscopy, a lobulated pink-yellowish solid mobile mass was observed on the nasal bulbar conjunctival surface of his left eye. The tumor was excised, and histopathologic examination of the tumor revealed a sebaceous adenoma. Read More

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http://dx.doi.org/10.5935/0004-2749.20160071DOI Listing
April 2017
3 Reads

Lrig1 Expression in Human Sebaceous Gland Tumors.

Dermatopathology (Basel) 2016 Apr-Jun;3(2):44-54. Epub 2016 Jun 1.

Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.

Background: Sebaceous glands contribute significantly to the barrier functions of the skin. However, little is known about their homeostasis and tumorigenesis. Recently, increased expression of stem cell marker Lrig1 has been reported in sebaceous carcinoma-like tumors of K14ΔNLef1 transgenic mice. Read More

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http://dx.doi.org/10.1159/000446427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965540PMC
August 2016
7 Reads

Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors.

JCI Insight 2016 Jul;1(11)

Department of Dermatology, Duke University, Duke University Medical Center, Durham, North Carolina, USA; Department of Pathology, Duke University, Durham, North Carolina, USA.

The deubiquitinase-encoding gene displays a dominant genetic linkage to a wide spectrum of skin-appendage tumors, which could be collectively designated as CYLD mutant-syndrome (CYLD-syndrome). Despite recent advances, little is understood about the molecular mechanisms responsible for this painful and difficult-to-treat skin disease. Here, we generated a conditional mouse model with epidermis-targeted expression of a catalytically deficient CYLD through K14-Cre-mediated deletion of exon 9 (hereafter refer to ). Read More

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http://dx.doi.org/10.1172/jci.insight.86548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966682PMC
July 2016
8 Reads

Growing papule on the right shoulder of an elderly man.

Cutis 2016 Jun;97(6):391-3

University of Pennsylvania, Philadelphia, USA.

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June 2016
6 Reads

Circumscribed sebaceous neoplasms: a morphological, immunohistochemical and molecular analysis.

Pathology 2016 Aug 14;48(5):454-62. Epub 2016 Jun 14.

Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, WA, Australia; Translational Cancer Pathology Laboratory, School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, WA, Australia.

Sebaceous neoplasms encompass a range of lesions, including benign entities such as sebaceous adenoma and sebaceoma, as well as sebaceous carcinoma. The distinction of sebaceous carcinoma from benign lesions relies on histological identification of architectural or cytological features of malignancy. In this study we have assessed the diagnostic discriminatory ability of mitotic rate and immunohistochemical markers (p53, bcl-2 and p16) in a selected group of well circumscribed sebaceous neoplasms, incorporating examples of sebaceous adenoma, sebaceoma and sebaceous carcinoma. Read More

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http://dx.doi.org/10.1016/j.pathol.2016.05.004DOI Listing
August 2016
6 Reads