799 results match your criteria Sebaceous Adenoma


Papillary Renal Cell Carcinoma in Lynch/Muir-Torre Syndrome with Germline Pathogenic Variant in and Molecular Analysis: Report of a Case and Review of the Literature.

J Kidney Cancer VHL 2021 21;8(2):8-19. Epub 2021 Apr 21.

Department of Pathology & Immunology.

Lynch syndrome (LS) is an autosomal dominant inherited disorder due to pathogenic variations in the mismatch repair genes, which predisposes to malignancies, most commonly colon and endometrial carcinoma. Muir-Torre syndrome is a subset of LS with cutaneous sebaceous adenoma and keratoacanthoma in addition to the malignancies. Renal cell carcinoma (RCC) in patients with LS is extremely rare. Read More

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Adipophilin expression in skin lesions with clear cell histology.

J Clin Pathol 2021 May 5. Epub 2021 May 5.

Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Aims: Clear cells formed due to depositions of glycogen or lipids in the cytoplasm commonly occur in various tissues. Adipophilin (ADP), a lipid regulatory protein, is closely related to lipid droplets. This study aims to examine adipophilin expression in clear cells of various skin lesions. Read More

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Comparison of adipophilin and recently-introduced PRAME immunohistochemistry in the assessment of sebaceous neoplasms: A pilot study.

J Cutan Pathol 2021 May 5. Epub 2021 May 5.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Background: We and others have noticed consistent staining of sebaceous glands with PRAME. We aimed to determine whether PRAME was as sensitive, specific, and interpretable as adipophilin for distinguishing sebaceous neoplasms (SNs) from other neoplasms.

Methods: Twenty SNs and 32 control cases were stained for PRAME and adipophilin. Read More

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MLH1 epimutation is a rare mechanism for Lynch syndrome: A case report and review of the literature.

Genes Chromosomes Cancer 2021 May 2. Epub 2021 May 2.

Department of Pathology and Laboratory Medicine, Sinai Health System and University of Toronto, Toronto, Ontario, Canada.

Endometrial carcinoma is one of the prototypical malignancies associated with Lynch syndrome, an inherited cancer syndrome most commonly caused by germline mutations in DNA mismatch repair (MMR) genes, although rare alternative mechanisms also exist. In this report, we describe a patient first diagnosed with colorectal cancer at age 33, then vulvar squamous cell carcinoma, facial sebaceous adenoma/sebaceoma, and finally endometrial carcinoma at age 52. All tumors were MLH1/PMS2-deficient by immunohistochemistry, and MLH1 promoter methylation was identified in the endometrial cancer. Read More

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Androgen and Estrogen Receptor Expression in Different Types of Perianal Gland Tumors in Male Dogs.

Animals (Basel) 2021 Mar 19;11(3). Epub 2021 Mar 19.

Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-612 Lublin, Poland.

Perianal gland tumors are modified sebaceous glands present in the skin of the perianal region in the dog. Hormonal stimulation may induce hyperplasia of the perianal glands or their neoplastic progression. The presence of androgen (AR) and estrogen (ER) receptors have been demonstrated both in normal perianal glands as well as in perianal tumors. Read More

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Non-sebaceous Lymphadenoma of the Parotid Gland Mimicking a Pleomorphic Adenoma.

Clin Pathol 2021 Jan-Dec;14:2632010X21996338. Epub 2021 Feb 23.

Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, México.

Non-sebaceous lymphadenoma of the salivary glands is a rare benign lesion, first described in 1991. We present the case of a 54-year-old woman, with a right parotid mass. She underwent right superficial parotidectomy, and histopathology reported a non-sebaceous lymphadenoma due to an encapsulated lesion and multiple non-atypical epithelial inclusions without sebaceous differentiation. Read More

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February 2021

An updated review of the sebaceous gland and its role in health and diseases Part 2: Pathophysiological clinical disorders of sebaceous glands.

Dermatol Ther 2021 Mar 19;34(2):e14862. Epub 2021 Feb 19.

Veterans Affairs Hospital and SUNY Downstate Dermatology Service, Brooklyn, New York, USA.

Sebaceous glands are sebum-secreting components of pilosebaceous units. In the second of this two-part series, we review the pathologies in which sebaceous glands are primarily and secondarily implicated. They are primarily involved in steatocystoma simplex and multiplex, sebaceous gland hyperplasia, sebaceoma, sebaceous adenoma, sebaceous carcinoma, nevus sebaceus, and folliculosebaceous cystic hamartoma. Read More

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A rare combination of holocrine poroma with follicular germinative differentiation.

J Dermatol 2021 Apr 9;48(4):e192-e193. Epub 2021 Feb 9.

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Nara, Japan.

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A case of Muir-Torre syndrome with a keratoacanthoma and sebaceous neoplasms: Clinicopathological features and a speculation on the pathogenesis of cutaneous tumor type.

J Dermatol 2021 May 1;48(5):690-694. Epub 2021 Feb 1.

Department of Dermatology, Hyogo Cancer Center, Akashi, Japan.

Muir-Torre syndrome is a hereditary condition characterized by occurrence of sebaceous neoplasms or keratoacanthomas and visceral tumors. The most common mechanism for this syndrome is a constitutional defect in the mismatch repair genes. We report the case of a 67-year-old woman with a mutator L homologue 1 (MLH1) mutation. Read More

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An updated review of the sebaceous gland and its role in health and diseases Part 1: Embryology, evolution, structure, and function of sebaceous glands.

Dermatol Ther 2021 Jan 1;34(1):e14695. Epub 2021 Jan 1.

Veterans Affairs Hospital and SUNY Downstate Dermatology Service, Brooklyn, New York, USA.

Sebaceous glands are sebum-secreting components of pilosebaceous units. The embryological development of the sebaceous gland follows that of the hair follicle and epidermal tissue, beginning between weeks 13 and 16 of fetal development. New sebaceous glands do not normally develop following birth, but their size increases with age. Read More

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January 2021

Sebaceous Epithelial-Myoepithelial Carcinoma With Aggressive Behavior and Evidence of Preexisting Pleomorphic Adenoma.

Int J Surg Pathol 2020 Dec 15:1066896920980804. Epub 2020 Dec 15.

University of Montreal, Montreal, Quebec, Canada.

Epithelial-myoepithelial carcinoma (EMCA) is a rare low-grade carcinoma of the salivary glands with multiple morphological variants. One such variant, sebaceous EMCA (SEMCA), has been reported in the literature. Distinguishing it from other tumors such as sebaceous carcinoma is crucial, as SEMCA typically behaves more indolently. Read More

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December 2020

Case for diagnosis. Verrucous plaque on the pubic region.

An Bras Dermatol 2021 Jan-Feb;96(1):103-105. Epub 2020 Nov 20.

Department of Dermatology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil.

Muir-Torre syndrome is a rare, autosomal dominant genodermatosis, characterized by sebaceous neoplasms and visceral carcinomas. The authors describe the case of a patient who, 16 years after the diagnosis of colon carcinoma, presented a verrucous plaque on the pubic region, histopathologically compatible with sebaceous adenoma. The need to investigate this syndrome is emphasized, especially in cases of sebaceous neoplasms located outside the head, face, and neck. Read More

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February 2021

Sebaceous Tumors of the Skin: A Study of 145 Lesions From 136 Patients Correlating Pathologic Features and DNA Mismatch Repair Staining Pattern.

Am J Dermatopathol 2021 Mar;43(3):174-181

Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.

Abstract: Sebaceous neoplasms occur sporadically or in the setting of Muir-Torre syndrome. The data regarding the correlation of pathologic features and DNA mismatch repair (MMR) staining pattern in sebaceous tumors of the skin are very scanty and based on relatively small series of patients. The goal of this study was to correlate MMR staining pattern with selected morphological features in a series of 145 sebaceous neoplasms (sebaceous adenoma, sebaceoma, and extraocular sebaceous carcinoma) from 136 patients. Read More

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Bioinformatics analysis of the microRNA-mRNA network in sebaceous gland carcinoma of the eyelid.

Mol Med Rep 2021 01 12;23(1). Epub 2020 Nov 12.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Sebaceous gland carcinoma (SGC) of the eyelid is an uncommon aggressive tumor with a relatively high rate of local recurrence and a poor prognosis following metastasis. However, the molecular mechanisms underlying the pathogenesis of SGC remain unclear. The purpose of the present study was to clarify microRNA (miRNA) expression profiles in SGC and to explore novel miRNA‑mRNA networks of SGC. Read More

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January 2021

Sebaceoma of a Meibomian Gland of the Upper Eyelid.

Ocul Oncol Pathol 2020 Aug 22;6(4):297-304. Epub 2020 Jan 22.

Department of Oculoplastics, Massachusetts Eye and Ear/Harvard Medical School, Boston, Massachusetts, USA.

Over a period of 1 year, a 74-year-old man slowly developed a painless left upper eyelid intratarsal mass. The skin was movable over the lesion. At surgery, a well-circumscribed, yellow-white, partially cystic tumor was encountered. Read More

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Villous Sebaceous Adenoma Arising from the Caruncular Surface Squamous Epithelium.

Ocul Oncol Pathol 2020 Aug 10;6(4):280-286. Epub 2020 Mar 10.

Department of Ophthalmic Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

A 68-year-old woman developed an asymptomatic left caruncular multilobular lesion over one year. Excision of the lesion displayed a benign sebaceous neoplasm taking origin from the surface squamous epithelium which invaginated into the stroma to create crypts resembling the conjunctival pseudoglands of Henle or the glands of Lieberkuhn of the small intestine. Scattered sebaceous cells were also discovered in the surface squamous epithelium. Read More

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Muir-Torre Syndrome Associated Periocular Sebaceous Neoplasms: Screening Patterns in the Literature and in Clinical Practice.

Ocul Oncol Pathol 2020 Aug 15;6(4):226-237. Epub 2020 Jan 15.

Department of Ophthalmic Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Background: Muir-Torre syndrome (MTS) is defined clinically as the association of cutaneous sebaceous neoplasm and visceral malignancy. Ancillary tests are considered crucial for diagnosis. Although screening guidelines for MTS, including the Mayo MTS scoring system, have been proposed, there are no ophthalmic site-specific guidelines. Read More

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Genetic heterogeneity in a patient with Muir-Torre syndrome.

JAAD Case Rep 2020 Sep 9;6(9):886-891. Epub 2020 Jul 9.

Pathology and Lab Medicine Services, VA New Jersey Medical Center, East Orange, New Jersey.

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September 2020

A string of nodular lesions along the leg.

J Dtsch Dermatol Ges 2020 Jul 25;18(7):774-776. Epub 2020 May 25.

Department of Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

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Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: case report and review of nevus sebaceus-associated conditions.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

School of Medicine, University of California San Diego, La Jolla, CA.

Nevus sebaceus is a benign skin hamartoma of congenital onset that grows during puberty, and in adulthood can develop secondary benign and malignant neoplasms. The most common benign neoplasms occurring in nevus sebaceus are believed to be syringocystadenoma papilliferum, trichilemmoma, and trichoblastoma. A patient with nevus sebaceus developed not only syringocystadenoma papilliferum but also prurigo nodularis within her hamartomatous lesion; multiple biopsies were necessary to establish the diagnoses. Read More

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February 2020

Increased Lipid Accumulation under Hypoxia in SZ95 Human Sebocytes.

Dermatology 2021 21;237(1):131-141. Epub 2020 Feb 21.

Department of Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea,

Background: Excessive sebum is produced by specialized cells called sebocytes and is considered a cause or consequence of acne, sebaceous cysts, hyperplasia, and sebaceous adenoma.

Objective: To report changes in lipid accumulation in human sebocytes under hypoxia, which occurs under conditions of seborrhea.

Methods: Sebocytes from the immortalized human gland cell line SZ95 were cultured under conditions of hypoxia for 48 h; lipid formation was confirmed by Nile red and Oil Red O staining. Read More

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February 2020

Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.

Diagn Cytopathol 2020 May 22;48(5):424-429. Epub 2020 Jan 22.

Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri.

Background: Sebaceous lymphadenomas and sebaceous lymphadenocarcinomas are uncommon neoplasms occurring predominately within the parotid gland. Cytomorphology of these neoplasms is rarely reported. Occasional reports have discussed the cytomorphological features of these neoplasms but criteria distinguishing sebaceous lymphadenomas from lymphadenocarcinomas have not been described. Read More

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Preputial gland adenoma in a wild nutria (): a case report.

J Vet Sci 2020 Jan;21(1):e1

Department of Veterinary Pathology, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea.

Tumor incidence in wild mammals is reportedly very low. Wild nutria, a large rodent, is known to carry many infectious diseases, but rarely exhibits neoplastic diseases. We necropsied a male wild nutria and found a large nodular mass in the left inguinal region, adjacent to the penis. Read More

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January 2020

Sebaceous Adenoma in a Patient With Visceral Malignancies.

Ophthalmic Plast Reconstr Surg 2020 Sep/Oct;36(5):e136

Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, U.S.A.

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Update on the pathology, genetics and somatic landscape of sebaceous tumours.

Histopathology 2020 Apr 17;76(5):640-649. Epub 2020 Mar 17.

Department of Pathology & Laboratory Medicine, The Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Cutaneous sebaceous neoplasms show a predilection for the head and neck area of adults and include tumours with benign behaviour, sebaceous adenoma and sebaceoma, and sebaceous carcinoma with potential for an aggressive disease course at the malignant end of the spectrum. The majority of tumours are solitary and sporadic, but a subset of tumours may be associated with Lynch syndrome, also known as hereditary non-polyposis colon cancer (HNPCC) and previously referred to as Muir-Torre syndrome (now known to be part of Lynch syndrome). This review provides an overview of the clinical and histological features of cutaneous sebaceous neoplasia with an emphasis on differentiating features and differential diagnosis. Read More

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Sebaceoma on the scalp simulating a malignant pigmented neoplasia.

An Bras Dermatol 2019 Sep - Oct;94(5):590-593. Epub 2019 Sep 30.

ID - Investigação em Dermatologia, Rio de Janeiro, RJ, Brazil.

The correct identification of pigmented nodular lesions of the scalp is often challenging. Despite the importance of clinical patterns and dermoscopy, important adjuvant tools that are usually helpful, their interpretation sometimes is not clear-cut. Here, the authors discuss a case of sebaceoma mimicking a malignant pigmented neoplasia, with conclusive histopathology. Read More

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December 2019

Tumors of the conjunctiva and cornea.

Indian J Ophthalmol 2019 12;67(12):1930-1948

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Tumors of the conjunctiva and cornea comprise a large and varied spectrum of conditions. These tumors are grouped into two major categories of congenital and acquired lesions. The acquired lesions are further subdivided based on origin of the mass into surface epithelial, melanocytic, vascular, fibrous, neural, histiocytic, myxoid, myogenic, lipomatous, lymphoid, leukemic, metastatic and secondary tumors. Read More

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December 2019

Ocular Adnexal Adenomatoid Sebaceous Gland Hyperplasia: A Clinical and Immunopathologic Analysis in Relation to the Muir-Torre Syndrome.

Ophthalmic Plast Reconstr Surg 2020 Jan/Feb;36(1):e6-e12

Department of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.

The purpose of this study is to codify the microscopic diagnostic criteria for ocular adnexal brow and caruncular sebaceous gland hyperplasias (pseudoadenomatoid) that distinguish it from an adenoma. Clinical records and photographs were critically reviewed and microscopic slides were stained with hematoxylin and eosin and immunochemically stained for adipophilin, androgen receptor, p16, p53, a spectrum of cytokeratins, Ki-67 and mismatch repair nuclear protein expression for MLH1, MSH2, PMS2, and MSH6. The patients and their close relatives had no history of cancer. Read More

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