825 results match your criteria Sebaceous Adenoma

Epithelial-myoepithelial carcinoma ex pleomorphic adenoma of the parotid gland with unique histologic differentiation: A rare case report.

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S34-S39. Epub 2022 Feb 28.

Oral Medicine and Radiology, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.

Epithelial myoepithelial carcinoma (EMC) is an uncommon low-to-intermediate grade salivary gland malignancy that accounts for 1% of all tumors arising in salivary glands. About 80% of these tumors affect the parotid gland. These lesions either arise or from existing pleomorphic adenoma (PA). Read More

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February 2022

Development of seven secondary neoplasms in a nevus sebaceous: a case report and literature review.

Arch Craniofac Surg 2022 Apr 30;23(2):83-88. Epub 2022 Mar 30.

International Aesthetic Medical Center, E-Da Dachang Hospital, Kaohsiung, Taiwan.

Nevus sebaceous of Jadassohn is a congenital cutaneous hamartoma with epidermal, sebaceous, follicular, and apocrine structures that usually appears at birth or in early childhood. It has the potential to generate a variety of secondary neoplasms of different lineages, and the risk increases with patient age. Although multiple neoplasms may occasionally arise within the same lesion, the coexistence of more than five secondary tumors is extremely rare. Read More

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Impaired Wnt/beta-catenin and protein patched homolog 1 signaling in extraocular sebaceous carcinoma: A clinical and histopathological study.

J Dermatol 2022 Mar 22. Epub 2022 Mar 22.

Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Sebaceous carcinoma (SC) is a rare malignant neoplasm with sebaceous differentiation. SC is classified into eyelid and extraocular SC clinically. Most studies have focused on the eyelid SC in terms of pathogenesis, treatment, and prognosis. Read More

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Sebaceous Lymphadenoma of Parotid: Case Report of a Rare Entity.

Indian J Surg Oncol 2021 Dec 13;12(Suppl 2):351-354. Epub 2021 Jun 13.

Ruby Hall Clinic, 40, Sassoon Road, Pune, 411001 India.

Sebaceous differentiation can be normally seen in salivary glands. An entity first described by Hamperi. Sebaceous components are present in several salivary gland tumors like Warthin's tumor and mucoepidermoid tumor. Read More

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December 2021

[Isolated conjunctival sebaceous adenoma associated with acute endophtalmitis].

Rev Esp Patol 2022 Jan-Mar;55(1):68-72. Epub 2019 Mar 16.

Servicio de Anatomía Patológica, Hospital Universitario Dexeus, Barcelona, España.

Sebaceous adenoma of the conjunctiva is a very rare lesion of uncertain origin. It is usually associated with Muir-Torre syndrome in which neoplasms are also found in other parts of the body. We present the case of a 71-year-old man without a previous or family history of neoplasia, who presented with severe inflammation and an infection in his right eye associated with a tumor of the conjunctiva near the caruncle. Read More

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Microsatellite Instability in Near East Sebaceous Neoplasms: Toward Improved Prediction.

Appl Immunohistochem Mol Morphol 2022 03;30(3):204-208

Pathology Consultant, Greater Cincinnati Pathologists,The Christ Hospital, Cincinnati, OH.

Sebaceous neoplasms (SN) comprise a heterogeneous spectrum of tumors with different biological behaviors. In the Near-East Region (NER), microsatellite instability (MSI) in SN's development, and its correlation with the clinicopathologic features of tumors is not well elucidated. A cohort of 225 SN patients (40 benign SNs and 185 sebaceous carcinomas) from the NER was retrospectively reviewed. Read More

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Nevus Sebaceous of the Scalp With Stepwise Progression Into Invasive Syringocystadenocarcinoma Papilliferum.

Am J Dermatopathol 2021 Dec;43(12):965-969

Dermatopathology, Bodensee, Friedrichshafen, Germany.

Syringocystadenocarcinoma papilliferum (SCACP), the malignant counterpart of syringocystadenoma papilliferum (SCAP), is an extremely rare malignant adnexal neoplasm. It is described by the World Health Organization as a malignant transformation of SCAP occurring in middle-aged to elderly individuals with a predilection for the head and neck. SCACP seems to arise from a long-standing syringocystadenoma probably on a background of nevus sebaceous (NS) through a multistep progression. Read More

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December 2021

A non-classic form of McCune Albright syndrome with different presentations and review of the literatures.

Caspian J Intern Med 2021 ;12(Suppl 2):S401-S403

Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: McCune Albright syndrome (MAS) is a rare heterogeneous clinical syndrome without any predilection for ethnic group. Classic form includes triad of fibrous dysplasia, café au late spots and autonomous hyper function of one or more endocrine pathways.

Case Report: We report the case of an 18-year old girl with non-classic form of MAS . Read More

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January 2021

Expression and Significance of AQP3 in Cutaneous Lesions.

Anal Cell Pathol (Amst) 2021 26;2021:7866471. Epub 2021 Oct 26.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, China.

Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions. We analyzed AQP3 mRNA levels using RT-PCR in 311 cutaneous lesions and confirmed AQP3 expression in these lesions by immunohistochemistry. Read More

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Ten-year epidemiological study of ocular and orbital tumors in Chiba University Hospital.

BMC Ophthalmol 2021 Sep 23;21(1):344. Epub 2021 Sep 23.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, 260-8670, Japan.

Background: The purpose of this study is to determine the epidemiology of tumors of the ocular adnexa and orbit in Japan.

Methods: We conducted a retrospective study on the histopathological reports in the medical records of the Chiba University Hospital from April 2009 to March 2019. Three hundred and seventy two records were examined. Read More

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September 2021

Extracapsular Dissection for Small Benign Tumors of Parotid Gland: A Case Report on Contemporary Technique.

Cureus 2021 Aug 8;13(8):e17007. Epub 2021 Aug 8.

Department of Oral and Maxillofacial Surgery, St. Joseph Dental College, Eluru, IND.

Salivary gland tumor looms as painless enlarging mass which may embrace in both major or minor glands. Pleomorphic adenoma (PA) accord about 40-70% of all salivary gland tumors, where Warthin tumor, basal cell adenoma (BCA), adenoid cystic carcinoma (ACC), and sebaceous tumors have a strong predilection for major salivary gland. However, polymorphous low-grade adenocarcinoma (PLGA) has a marked predilection for the minor salivary gland. Read More

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Sebaceous adenoma of the conjunctiva and caruncle: a clinicopathological report of three cases and literature review.

Arq Bras Oftalmol 2021 18;85(2):174-177. Epub 2021 Aug 18.

Ocular Oncology Service, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Sebaceous tumors of the conjunctiva and caruncle are rare conditions, accounting for 1% of caruncle lesions and even lower among conjunctival lesions. Almost 50% of cases are associated with Muir-Torre syndrome, a rare autosomal-dominant condition characterized by at least one sebaceous skin tumor and one visceral malignancy. We report 3 cases of sebaceous adenoma with different presentations that were submitted to excisional biopsy and immunohistochemical study. Read More

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Trilogy Revisited: A Case Report of Co-Existing Nevus Sebaceous with Syringocystadenoma Papilliferum and Tubular Apocrine Adenoma.

Indian Dermatol Online J 2021 Jul-Aug;12(4):577-579. Epub 2021 Jul 14.

Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Nevus sebaceous of Jadassohn is a cutaneous hamartoma that is associated with various benign and malignant cutaneous tumors. Syringocystadenoma papilliferum and tubular apocrine adenoma are rare benign adnexal tumors. Simultaneous occurrence of all three tumors at the same site is extremely rare, which has raised several questions regarding their origin and pose a diagnostic challenge owing to considerable overlap in clinical and histological features. Read More

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GLUT1 Expression in Cutaneous Sebaceous Lesions Determined by Immunohistochemical Staining Patterns.

Dermatopathology (Basel) 2021 Jul 5;8(3):258-264. Epub 2021 Jul 5.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.

GLUT1 is a membrane associated carrier protein that functions in the physiologic transport of glucose across cell membranes. Multiple studies have shown an increased GLUT1 expression in various tumor types and a role in cancer prognosis. The aim of this study was to determine whether cutaneous sebaceous lesions have a differential expression of GLUT1 by immunohistochemistry (IHC). Read More

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Rare upper lip pleomorphic adenoma presents as cutaneous skin lesion: Case report.

Int J Surg Case Rep 2021 Aug 29;85:106142. Epub 2021 Jun 29.

Department of Surgery, King Khalid University Hospital, King Saud University, Saudi Arabia.

Introduction: Pleomorphic adenoma of the minor salivary gland is not uncommon. Although malignant lesion is the most common in the minor salivary glands, benign lesion has been also reported. Many ectopic sites for minor salivary gland including the lip have been reported mainly intra-orally. Read More

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Pleomorphic Adenoma of the Submandibular Gland in a 10-Year-Old Child: A Case Report.

Ear Nose Throat J 2021 Jul 8:1455613211022113. Epub 2021 Jul 8.

ENT Department, Fattouma Bourguiba Hospital of Monastir, Monastir, Tunisia.

We report the case of a 10-year-old girl with a painless slowly growing mass that had developed over the course of 2 years in the left submandibular area. Physical examination revealed a firm painless submandibular mass with no other associated signs. Ultrasound graphics were in favor of a sebaceous cyst. Read More

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A Case of Muir-Torre Syndrome.

Cureus 2021 Apr 20;13(4):e14582. Epub 2021 Apr 20.

Hematology/Oncology, Henry Ford Health System, Jackson, USA.

Muir-Torre syndrome (MTS) is an autosomal dominant condition characterized by dermatological tumors along with visceral malignancies. The dermatological manifestations include recurrent sebaceous adenomas and keratoacanthomas. The commonly seen visceral malignancies are colorectal, gynecological, and urological. Read More

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Molecular Genetics of Sebaceous Neoplasia.

Jeffrey P North

Surg Pathol Clin 2021 Jun;14(2):273-284

Dermatopathology, Department of Dermatology, University of California San Francisco, School of Medicine, 1701 Divisadero Street, Room 280, San Francisco, CA 94115, USA; Department of Pathology, University of California San Francisco, School of Medicine, 1701 Divisadero Street, Room 280, San Francisco, CA 94115, USA. Electronic address:

Sebaceous neoplasia primarily includes sebaceous adenoma, sebaceoma, and sebaceous carcinoma (SC). Sebaceous adenoma, sebaceoma, and a subset of cutaneous SC are frequently associated with defective DNA mismatch repair resulting from mutations in MLH1, MSH2, or MSH6. These tumors can be sporadic or associated with Muir-Torre syndrome. Read More

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Sebaceous neoplasms: prevalence of HPV infection and relation to immunohistochemical surrogate markers.

Eur J Dermatol 2021 Apr;31(2):170-175

Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Sebaceous neoplasms (SNs) and carcinomas (SCs) represent rare skin adnexal tumours.

Objectives: To establish the prevalence of HPV in SNs, assess the relationship between HPV, p16 and p53 expression, and further elucidate the carcinogenetic course of SCs.

Materials & Methods: A total of 113 resected SNs (five sebaceous adenomas, 10 sebaceomas and 98 SCs) from the Near-East were reviewed. Read More

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Papillary Renal Cell Carcinoma in Lynch/Muir-Torre Syndrome with Germline Pathogenic Variant in and Molecular Analysis: Report of a Case and Review of the Literature.

J Kidney Cancer VHL 2021 21;8(2):8-19. Epub 2021 Apr 21.

Department of Pathology & Immunology.

Lynch syndrome (LS) is an autosomal dominant inherited disorder due to pathogenic variations in the mismatch repair genes, which predisposes to malignancies, most commonly colon and endometrial carcinoma. Muir-Torre syndrome is a subset of LS with cutaneous sebaceous adenoma and keratoacanthoma in addition to the malignancies. Renal cell carcinoma (RCC) in patients with LS is extremely rare. Read More

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Adipophilin expression in skin lesions with clear cell histology.

J Clin Pathol 2021 May 5. Epub 2021 May 5.

Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Aims: Clear cells formed due to depositions of glycogen or lipids in the cytoplasm commonly occur in various tissues. Adipophilin (ADP), a lipid regulatory protein, is closely related to lipid droplets. This study aims to examine adipophilin expression in clear cells of various skin lesions. Read More

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Comparison of adipophilin and recently introduced PReferentially expressed Antigen in MElanoma immunohistochemistry in the assessment of sebaceous neoplasms: A pilot study.

J Cutan Pathol 2021 Oct 17;48(10):1252-1261. Epub 2021 May 17.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Background: We and others have noticed consistent staining of sebaceous glands with PReferentially expressed Antigen in MElanoma (PRAME). We aimed to determine whether PRAME was as sensitive, specific, and interpretable as adipophilin for distinguishing sebaceous neoplasms (SNs) from other neoplasms.

Methods: Twenty SNs and 32 control cases were stained for PRAME and adipophilin. Read More

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October 2021

High-risk human papillomavirus in ruxolitinib-associated sebaceous neoplasms.

Indian J Dermatol Venereol Leprol 2021 May-Jun;87(3):404-408

Department of Pathology, American University of Beirut Medical Center, Beirut, Lebanon.

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December 2021

MLH1 epimutation is a rare mechanism for Lynch syndrome: A case report and review of the literature.

Genes Chromosomes Cancer 2021 09 15;60(9):635-639. Epub 2021 May 15.

Department of Pathology and Laboratory Medicine, Sinai Health System and University of Toronto, Toronto, Ontario, Canada.

Endometrial carcinoma is one of the prototypical malignancies associated with Lynch syndrome, an inherited cancer syndrome most commonly caused by germline mutations in DNA mismatch repair (MMR) genes, although rare alternative mechanisms also exist. In this report, we describe a patient first diagnosed with colorectal cancer at age 33, then vulvar squamous cell carcinoma, facial sebaceous adenoma/sebaceoma, and finally endometrial carcinoma at age 52. All tumors were MLH1/PMS2-deficient by immunohistochemistry, and MLH1 promoter methylation was identified in the endometrial cancer. Read More

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September 2021

Genetic analyses of a secondary poroma and trichoblastoma in a HRAS-mutated sebaceous nevus.

J Dermatol 2021 Aug 27;48(8):1268-1272. Epub 2021 Apr 27.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

A sebaceous nevus is a congenital skin hamartoma caused by postzygotic HRAS or KRAS mosaic mutations. With age, affected individuals may develop secondary tumors within a sebaceous nevus. RAS mutations are harbored from the onset of sebaceous nevus, and further mutations can be expected to be required in order to explain the initiation of secondary tumors. Read More

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Androgen and Estrogen Receptor Expression in Different Types of Perianal Gland Tumors in Male Dogs.

Animals (Basel) 2021 Mar 19;11(3). Epub 2021 Mar 19.

Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-612 Lublin, Poland.

Perianal gland tumors are modified sebaceous glands present in the skin of the perianal region in the dog. Hormonal stimulation may induce hyperplasia of the perianal glands or their neoplastic progression. The presence of androgen (AR) and estrogen (ER) receptors have been demonstrated both in normal perianal glands as well as in perianal tumors. Read More

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TERT promoter mutation in sebaceous neoplasms.

Virchows Arch 2021 Sep 25;479(3):551-558. Epub 2021 Mar 25.

Department of Pathology, Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre, CIBERONC, Madrid, Spain.

TERT promoter (TERTp) mutations widely occur in multiple human neoplasms, and they have been related to different clinicopathological features. To date, this mutation has not been identified in sebaceous tumors. Here, we analyzed TERTp mutations in 91 sebaceous neoplasms (17 adenomas, 45 sebaceomas, and 29 carcinomas). Read More

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September 2021

Non-sebaceous Lymphadenoma of the Parotid Gland Mimicking a Pleomorphic Adenoma.

Clin Pathol 2021 Jan-Dec;14:2632010X21996338. Epub 2021 Feb 23.

Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, México.

Non-sebaceous lymphadenoma of the salivary glands is a rare benign lesion, first described in 1991. We present the case of a 54-year-old woman, with a right parotid mass. She underwent right superficial parotidectomy, and histopathology reported a non-sebaceous lymphadenoma due to an encapsulated lesion and multiple non-atypical epithelial inclusions without sebaceous differentiation. Read More

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February 2021

An updated review of the sebaceous gland and its role in health and diseases Part 2: Pathophysiological clinical disorders of sebaceous glands.

Dermatol Ther 2021 03 19;34(2):e14862. Epub 2021 Feb 19.

Veterans Affairs Hospital and SUNY Downstate Dermatology Service, Brooklyn, New York, USA.

Sebaceous glands are sebum-secreting components of pilosebaceous units. In the second of this two-part series, we review the pathologies in which sebaceous glands are primarily and secondarily implicated. They are primarily involved in steatocystoma simplex and multiplex, sebaceous gland hyperplasia, sebaceoma, sebaceous adenoma, sebaceous carcinoma, nevus sebaceus, and folliculosebaceous cystic hamartoma. Read More

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A rare combination of holocrine poroma with follicular germinative differentiation.

J Dermatol 2021 Apr 9;48(4):e192-e193. Epub 2021 Feb 9.

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Nara, Japan.

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