9,424 results match your criteria Sebaceous Adenoma


Thymic epithelial neoplasms with sebaceous differentiation: a clinicopathological and Immunohistochemical study of 8 cases.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, The university of Texas, M D Anderson Cancer Center, Houston, TX. Electronic address:

Eight cases of primary thymic epithelial neoplasms corresponding to seven thymomas and one thymic carcinoma with sebaceous differentiation are presented. The patients are five men and three women between the ages of 45 and 63years (average: 54years) who presented with non-specific symptomatology related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Read More

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December 2018

Malignant eyelid tumors: Are intra-operative rapid frozen section and permanent section diagnoses of surgical margins concordant?

Int Ophthalmol 2018 Dec 8. Epub 2018 Dec 8.

Ophthalmic Pathology Laboratory (DKM), L V Prasad Eye Institute, Hyderabad, India.

Purpose: To study the concordance between intra-operative rapid frozen section and permanent section diagnoses of surgical margins following wide surgical excisional biopsy of malignant eyelid tumors.

Methods: This is a retrospective study of 120 cases and 429 frozen section slides.

Results: Of 120 cases, 75 (63%) had sebaceous gland carcinoma, 34 (28%) had basal cell carcinoma, and 11 (9%) had squamous cell carcinoma. Read More

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December 2018

Immunoreactivity for Sox10 in Basaloid Neoplasms of The Skin.

Appl Immunohistochem Mol Morphol 2018 Dec 7. Epub 2018 Dec 7.

Section of Dermatopathology, Division of Surgical Pathology-Cytopathology, University of Virginia Medical Center, Charlottesville, VA.

Basaloid tumors of the skin pose a diagnostic challenge to pathologists, because the differential diagnosis is broad, sometimes with subtle differentiating features. We evaluated SOX10 expression in 120 primary cutaneous tumors with epidermal, sweat glandular, neuroendocrine/neuroectodermal, follicular, and sebaceous lineages. Our findings were compared with those of previous studies that evaluated SOX10 in tumors of the skin. Read More

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December 2018

Identification and regulation pattern analysis of long noncoding RNAs in meibomian gland carcinoma.

Epigenomics 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China.

Aim: To identify long noncoding RNAs (lncRNAs) and to elucidate regulation patterns of lncRNAs in meibomian gland carcinoma (MGC).

Materials & Methods: We used RNA-Seq, gene ontology, ClueGO, Ingenuity Pathway Analysis and co-expression network analyses to profile the expression and regulation patterns of lncRNAs and mRNAs in MGC.

Results: We identified 500 lncRNAs and 326 mRNAs as differentially expressed. Read More

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December 2018

Enhancement of lipid content and inflammatory cytokine secretion in SZ95 sebocytes by palmitic acid suggests a potential link between free fatty acids and acne aggravation.

Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.

A relationship between acne and free fatty acids (FFAs) has been suggested recently. However, the effects of FFAs on sebaceous glands are still largely unknown. At the same time, the role of FFAs during chronic inflammation is well established. Read More

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December 2018

Clinico-pathological predictors of mismatch repair deficiency in sebaceous neoplasia: A large case series from a single Australian private pathology service.

Australas J Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Clinical Pathology, Colorectal Oncogenomics Group, The University of Melbourne, Parkville, Victoria, Australia.

Background/objectives: Loss of expression of mismatch repair (MMR) proteins is frequently observed in sebaceous skin lesions and can be a herald for Lynch syndrome. The aim of this study was to identify clinico-pathological predictors of MMR deficiency in sebaceous neoplasia that could aid dermatologists and pathologists in determining which sebaceous lesions should undergo MMR immunohistochemistry (IHC).

Methods: An audit of sebaceous skin lesions (excluding hyperplasia) where pathologist-initiated MMR IHC was performed between January 2009 to December 2016 was undertaken from a single pathology practice identifying 928 lesions from 882 individuals. Read More

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December 2018
1 Read

Expression of Three Adipokines (Adiponectin, Leptin and Resistin) in Normal Canine Skin: a Pilot Study.

J Comp Pathol 2018 Nov 28. Epub 2018 Nov 28.

Dermatology/Parasitology/Mycology Unit, School of Veterinary Medicine-ONIRIS, University of Nantes, CS 40706, Nantes, France; NP3 Unit, School of Veterinary Medicine-ONIRIS, University of Nantes, CS 40706, Nantes 44307, France. Electronic address:

Adipokines are biologically active cytokines that are mainly produced in adipose tissue. There is evidence, in man and mice, that some adipokines may be secreted in other tissues including the vascular endothelium, epithelia and sebaceous glands. Moreover, modified serum levels of adipokines have been detected in people with acne vulgaris or psoriasis; it is suspected that adipokines could contribute to local and systemic inflammatory conditions. Read More

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November 2018
1 Read

Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma.

Pathology 2018 Nov 27. Epub 2018 Nov 27.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Hong Kong. Electronic address:

Malignant transformation of benign mature ovarian teratoma can result in a wide spectrum of cancer, including a variety of carcinoma, sarcoma, or melanoma. The role of mismatch repair defects in such malignant transformation is still elusive. In view of current immunotherapy, the role of mismatch repair deficiency can have significant implications on therapeutic strategy. Read More

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November 2018
1 Read

Degenerated hair follicle cells and partial loss of sebaceous and eccrine glands in a familial case of axenfeld-rieger syndrome: An emerging role for the FOXC1/NFATC1 genetic axis.

J Dermatol Sci 2018 Nov 10. Epub 2018 Nov 10.

Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon. Electronic address:

Background: Cutaneous malformations are at times associated with some forms of congenital heart defects. Many a times subtle cutaneous phenotypes maybe overlooked as their significance on the lives of individuals is minimal. Lebanon represents an area of high consanguinity, where the rates can go beyond 70% in some districts. Read More

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November 2018
2 Reads

Regional Control of Hairless versus Hair-Bearing Skin by Dkk2.

Cell Rep 2018 Nov 29. Epub 2018 Nov 29.

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA. Electronic address:

Haired skin is a defining characteristic of mammals. However, some specialized skin regions, such as human palms, soles and ventral wrist, and mouse plantar foot, are entirely hairless. Using mouse plantar skin as a model system, we show that the endogenous secreted Wnt inhibitor DKK2 suppresses plantar hair follicle development and permits the formation of hairless skin. Read More

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November 2018
1 Read

Clinicopathological characteristics of breast sebaceous adenocarcinoma.

Pol J Pathol 2018 ;69(3):226-233

Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. Read More

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January 2018
2 Reads

Understanding the microbial basis of body odor in pre-pubescent children and teenagers.

Microbiome 2018 Nov 29;6(1):213. Epub 2018 Nov 29.

Computational and Systems Biology, Genome Institute of Singapore, Singapore, 138672, Singapore.

Background: Even though human sweat is odorless, bacterial growth and decomposition of specific odor precursors in it is believed to give rise to body odor in humans. While mechanisms of odor generation have been widely studied in adults, little is known for teenagers and pre-pubescent children who have distinct sweat composition from immature apocrine and sebaceous glands, but are arguably more susceptible to the social and psychological impact of malodor.

Results: We integrated information from whole microbiome analysis of multiple skin sites (underarm, neck, and head) and multiple time points (1 h and 8 h after bath), analyzing 180 samples in total to perform the largest metagenome-wide association study to date on malodor. Read More

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November 2018
3 Reads

Les difficultés du diagnostic : du carcinome basocellulaire aux tumeurs trichoblastiques: From basal cell carcinoma to trichoblastic tumors: a diagnostic challenge.

Authors:
B Cribier

Ann Dermatol Venereol 2018 Nov;145 Suppl 5:VS3-VS11

Clinique dermatologique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address:

Basal cell carcinoma (BCC) is a very common tumor, of which the diagnosis is generally easy. Clinical prediction of histopathological subtype however is however often difficult, i.e. Read More

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November 2018
2 Reads

MALDI Imaging for Proteomic Painting of Heterogeneous Tissue Structures.

Proteomics Clin Appl 2018 Nov 24:e1800045. Epub 2018 Nov 24.

Proteopath GmbH, Trier 54296, Germany.

Purpose: To present matrix-assisted laser desorption/ionization (MALDI) imaging as a powerful method to highlight various tissue compartments.

Experimental Design: Formalin-fixed paraffin-embedded (FFPE) tissue of a uterine cervix, a pancreas, a duodenum, a teratoma, and a breast cancer tissue microarray (TMA) are analyzed by MALDI imaging and by immunohistochemistry (IHC). Peptide images are visualized and analyzed using FlexImaging and SCiLS Lab software. Read More

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November 2018
2 Reads

Male Genital Dermatology: A Primer for the Sexual Medicine Physician.

Sex Med Rev 2018 Nov 17. Epub 2018 Nov 17.

Tulane University School of Medicine, Department of Urology, New Orleans, LA, USA. Electronic address:

Introduction: The dermatologic conditions affecting the male genitalia are diverse and range from normal variants and benign growths to overt malignancy. Unfortunately, there is a dearth of urologic dermatology training in most residency programs, and many dermatologic lesions with a classic appearance on other areas of the body may have atypical presentations on the genitalia. Patients may present to a variety of physicians without receiving a definitive diagnosis, which can be highly distressing to the afflicted individual. Read More

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November 2018
7 Reads

Insights into the regeneration of skin from Acomys, the spiny mouse.

Exp Dermatol 2018 Nov 20. Epub 2018 Nov 20.

UF Genetics Institute & Department of Biology, University of Florida, Gainesville, Florida, USA.

Members of the Acomys genus, known as spiny mice, are unique among mammals in being perfectly capable of regenerating large areas of skin that have been removed. During this regenerative process hairs, sebaceous glands, erector pili muscles, adipocytes and the panniculus carnosus all regenerate and the dermis does not scar. We review here the processes that the epidermis and the individual components of the dermis undergo in the regeneration process of the spiny mouse, the molecules that have been identified as potentially being important in regeneration and relate this to what has been proposed as playing a role in studies from the lab mouse, Mus musculus. Read More

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November 2018

A retrospective study of 2228 cases with eyelid tumors.

Int J Ophthalmol 2018 18;11(11):1835-1841. Epub 2018 Nov 18.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China.

Aim: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015.

Methods: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Read More

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November 2018
2 Reads

Mediastinal mature teratoma perforating the right lung that was successfully resected with complete thoracoscopic surgery: A case report.

Int J Surg Case Rep 2018 Nov 2;53:299-302. Epub 2018 Nov 2.

Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, Japan.

Introduction: A perforating mediastinal mature teratoma can cause severe inflammation and adhesion; therefore, open surgery is usually performed. Asymptomatic perforation involving a teratoma is very rare. Complete thoracoscopic surgery is often difficult because of inflammation associated with perforation and the frequently large size of a mediastinal mature teratoma. Read More

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November 2018
3 Reads

Study on the transdermal penetration mechanism of ibuprofen nanoemulsions.

Drug Dev Ind Pharm 2018 Nov 16:1-9. Epub 2018 Nov 16.

a Department of Pharmaceutics, School of Pharmacy , Anhui University of Chinese Medicine , Hefei , China.

Objective: The purpose of this study was to research the mechanism of percutaneous penetration of Ibuprofen (IBU) nanoemulsion.

Method: Transdermal penetration mechanism of IBU nanoemulsion was investigated by using Fourier transform infra-red spectral analysis (FTIR), differential scanning calorimeter thermogram (DSC), and activation energy (Ea) measurement. The in vivo skin penetration test of rats was carried out using Rhodamine B nanoemulsion to simulate the process of drug penetration into the skin, and the frozen section of the skin was observed by confocal laser scanning microscopy (CLSM). Read More

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November 2018
1 Read

The Structure of Human Sebaceous Glands and Its Relation to Skin Viscoelasticity.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:3460-3463

High-frequency ultrasound has realized high-resolution observation of deep part of the dermis in vivo. The size of sebaceous glands was evaluated by three-dimensional ultrasound microscopy with the ultrasonic frequency of 120 MHz. The viscoelasticity of the same regions was measured by well-established biomechanical equipment. Read More

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Cutaneous sebaceous tumours and Lynch syndrome: long-term follow-up of 60 patients.

Clin Exp Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Hospital Universitari de Bellvitge, IDIBELL, Universitat de Barcelona, Barcelona, Spain.

Background: Sebaceous neoplasms (SN) may appear sporadically in the general population but may also be part of the Muir-Torre variant of Lynch syndrome (MT-LS). There are few studies in southern Europe on the incidence of MT-LS in the population of patients with SN.

Aim: To retrospectively review patients with SN and to analyse their clinical features and the incidence of MT-LS. Read More

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November 2018

Eruptive sebaceous hyperplasias secondary to ciclosporin in a renal transplant patient.

Rev Clin Esp 2018 Nov 10. Epub 2018 Nov 10.

Servicio de Dermatología, Hospital Universitario Miguel Servet, Zaragoza, España.

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November 2018

Distinct biological types of ocular adnexal sebaceous carcinoma: HPV-driven and virus-negative tumors arise through non-overlapping molecular-genetic alterations.

Clin Cancer Res 2018 Nov 12. Epub 2018 Nov 12.

Head and Neck Surgery, Section of Ophthalmology, MD Anderson Cancer Center.

Purpose: Ocular adnexal (OA) sebaceous carcinoma is an aggressive malignancy of the eyelid and ocular adnexa that frequently recurs and metastasizes, and effective therapies beyond surgical excision are lacking. There remains a critical need to define the molecular-genetic drivers of the disease to understand carcinomagenesis and progression and to devise novel treatment strategies.

Experimental Design: We present next generation sequencing of a targeted panel of cancer-associated genes in 42 and whole transcriptome RNA sequencing from 8 OA sebaceous carcinomas from 29 patients. Read More

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November 2018
3 Reads
8.720 Impact Factor

[Trained eye vs. gold standard].

Semergen 2018 Nov 8. Epub 2018 Nov 8.

Medicina Familiar y Comunitaria, Centro de Salud Ciudad Real I, Ciudad Real, España.

Objective: To determine the degree of correlation between the clinical diagnosis prior to the minor surgery process and its concordance with the results of histopathology report, as well as to determine the surgical data of little clinical importance compared to that which is really necessary and cost-effective.

Material And Method: A descriptive, observational, retrospective and transversal study was conducted of the Minor Surgery Activities of a clinic in the Ciudad Real Health Centre I.

Results: A total of 124 surgical specimens were sent for clinical diagnostic comparison, of which, the main clinical diagnoses were: intradermal melanocytic nevi (34. Read More

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November 2018
1 Read

Lamellar rotation surgery: a new procedure for repairing upper eyelid defects.

Authors:
Qingji Li

BMC Ophthalmol 2018 Nov 7;18(1):291. Epub 2018 Nov 7.

Department of Oculoplastic and Reconstructive Surgery, Tianjin Aier Eye Hospital, No.102, Fukang Road, Nankai District, Tianjin, 300190, People's Republic of China.

Background: To report "Lamellar Rotation Surgery",a new technique for repairing large and moderate full-thickness upper eyelid defects.

Methods: A two-stage technique is described in which a vertical incision is made in the tarsus of the lower eyelid with elevation of the lateral posterior lamella while sparing the lower eyelid orbicularis and skin to be rotated superiorly to form the reconstructed posterior lamella of the upper eyelid. Additionally, a lateral periosteal flap is used to reconstruct the lateral canthal tendon, and a McGregor procedure is used to reconstruct the anterior lamella of the upper eyelid. Read More

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November 2018
2 Reads

Development of new 3D human ex vivo models to study sebaceous gland lipid metabolism and modulations.

Cell Prolif 2018 Nov 6:e12524. Epub 2018 Nov 6.

CTIBIOTECH, Meyzieu-Lyon, France.

Objectives: Sebaceous glands maintain skin homeostasis by producing sebum. Low production can induce hair loss and fragile skin. Overproduction provokes seborrhoea and may lead to acne and inflammatory events. Read More

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November 2018

Linear papules and plaques on the posterior shoulders of a teenage male.

Pediatr Dermatol 2018 Nov;35(6):854-855

Department of Dermatology, Oregon Health and Science University, Portland, Oregon.

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November 2018
2 Reads

Dermatological conditions seen in renal transplant recipients in a Singapore tertiary hospital.

Singapore Med J 2018 Oct;59(10):519-523

Department of Dermatology, Singapore General Hospital, Singapore.

Introduction: Lifelong immunosuppression after renal transplant exerts effects on the recipients' skin, including skin infections, skin cancers and drug-induced skin disorders. Our study aimed to determine the epidemiology of skin conditions among renal transplant recipients in the largest tertiary hospital in Singapore.

Methods: We reviewed the medical records of kidney transplant recipients at Singapore General Hospital, Singapore, between 1 January 2003 and 31 December 2013. Read More

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October 2018
5 Reads

[Sebaceous hamartoma on the face: about a case].

Pan Afr Med J 2018 14;30:132. Epub 2018 Jun 14.

Service de Dermatologie-Vénérologie, Hôpital d'Instruction Mohammed V, Rabat, Maroc.

Sebaceous naevus (sebaceous hamartoma) is a congenital lesion mainly localized to the scalp, whose clinical and histologic diagnosis is generally easy. In the vast majority of cases, it is diagnosed at birth, but it can sometimes go unnoticed and give the impression to occur later. This lesion may be complicated by benign tumors or more rare malignancies. Read More

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November 2018
5 Reads

Cutaneous Skeletal Hypophosphatemia Syndrome in Association with a Mosaic Mutation.

Ann Clin Lab Sci 2018 Sep;48(5):665-669

Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Korea

Recent molecular genetic studies have revealed that Schimmelpenning-Feuerstein-Mims syndrome (SFMS), which presents as sebaceous nevi, is a mosaic RASopathy caused by postzygotic somatic activating mutations in , , or Some patients with SFMS also have hypophosphatemic rickets, called cutaneous skeletal hypophosphatemia syndrome (CSHS). We here report a pediatric case of biopsy-proven CSHS with mosaic mutation in the gene. A girl who showed extensive nevus sebaceous since birth had suffered progressive lower extremity deformity since the age of 5 years. Read More

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September 2018
7 Reads

Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid - a population-based analysis.

Orbit 2018 Oct 29:1-8. Epub 2018 Oct 29.

a Department of Ophthalmology , Oakland University William Beaumont School of Medicine , Royal Oak , MI , USA.

Purpose: To evaluate prognostic factors and survival of patients with sebaceous carcinoma of the eyelid through a population-based analysis.

Methods: A total of 940 patients with primary sebaceous carcinoma of the eyelid were derived from the Surveillance, Epidemiology, and End Results (SEER) database in the United States from 1973 to 2013. Kaplan-Meier univariate analysis and Cox Regression multivariate analysis were performed to examine prognostic factors in overall survival (OS). Read More

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October 2018

Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia.

PLoS One 2018 29;13(10):e0205775. Epub 2018 Oct 29.

The Jackson Laboratory, Bar Harbor, Maine, United States of America.

In a large scale screen for skin, hair, and nail abnormalities in null mice generated by The Jackson Laboratory's KOMP center, homozygous mutant Far2tm2b(KOMP)Wtsi/2J (hereafter referrred to as Far2-/-) mice were found to develop focal areas of alopecia as they aged. As sebocytes matured in wildtype C57BL/NJ mice they became pale with fine, uniformly sized clear lipid containing vacuoles that were released when sebocytes disintegrated in the duct. By contrast, the Far2-/- null mice had sebocytes that were similar within the gland but become brightly eosinophilic when the cells entered the sebaceous gland duct. Read More

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October 2018
3 Reads

Merkel cells in extraocular sebaceous carcinoma.

J Cutan Pathol 2018 Oct 25. Epub 2018 Oct 25.

Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, California.

Introduction: Mature sebaceous glands do not contain Merkel cells. Neither do sebaceous tumors in the vast majority of cases. Recently, however, it was showed that rare sebaceous adenomas with a carcinoid-like or labyrinthine pattern can contain intratumoral Merkel cells. Read More

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October 2018
2 Reads

Malignant Transformation of Mature Cystic Teratoma: Is Squamous Cell Carcinoma Different From the Other Types of Neoplasm?

Int J Gynecol Cancer 2018 Nov;28(9):1650-1656

Department of Obstetrics and Gynecology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.

Objectives: Malignant transformation of mature cystic teratoma (MCT) is rare. Unlike squamous cell carcinoma (SCC) in MCT, the other types of neoplasm in MCT have not been discussed in publications. We analyzed the clinical characteristics and prognosis of the other types of neoplasm (non-SCC) compared with those of SCC. Read More

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November 2018
3 Reads

СLINICAL AND LABORATORY CHARACTERISTICS OF PATIENTS WITH ADOLESCENCE ACNE AND ACNE TARDA.

Georgian Med News 2018 Sep(282):103-106

JSC "Astana Medical University", Kazakhstan.

Acne is a chronic recurrent androgen-mediated disease of the pilosebaceous complex with a multifactorial genetically determined development mechanism. Currently, there is a tendency to persistent course of the disease, resistance to therapy forms of acne, late debut and change the clinical picture of acne. This could be due to various factors, such as polycystic ovary syndrome, microadenoma and pituitary adenoma, congenital adrenal hyperplasia, SAHA syndrome, etc. Read More

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September 2018
1 Read

The Healing Effects of Conditioned Medium Derived from Mesenchymal Stem Cells on Radiation-Induced Skin Wounds in Rats.

Cell Transplant 2018 Oct 23:963689718807410. Epub 2018 Oct 23.

1 Department of Orthopedics, China-Japan Union of Jilin University, Changchun, Jilin, China.

Radioactive dermatitis is caused by the exposure of skin and mucous membranes to radiation fields. The pathogenesis of radioactive dermatitis is complex and difficult to cure. Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) may serve as a promising candidate for the therapy of cutaneous wounds. Read More

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October 2018

An Ulcerated Reddish Nodule of the Chest: When You See, Think ….

Dermatopathology (Basel) 2018 Jul-Sep;5(3):117-120. Epub 2018 Sep 19.

Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

A 97-year-old man with a previous personal history of multiple nonmelanoma skin cancers presented with a fast-growing, ulcerated reddish nodule on his chest. The nodule was surgically removed, and hematoxylin and eosin stains of the specimen showed an asymmetrical, nonpigmented lesion with architectural and structural impairment, round cells with clear, whitish, foamy cytoplasm, multiple dermal mitoses and nuclear pleomorphism. Our first hypothesis was sebaceous carcinoma, a rare malignant neoplasm derived from epithelial cells showing sebaceous differentiation. Read More

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September 2018
7 Reads

The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study.

Br J Dermatol 2018 Oct 16. Epub 2018 Oct 16.

Divisionof Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Background: Recent studies have shown an increasing incidence of cutaneous adnexal carcinomas (CACs) over the years.

Objective: The aim of our study was to evaluate incidence and survival of CACsand investigate their association with other skin neoplasms.

Methods: Population based study. Read More

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October 2018
2 Reads

Super Thick Amniotic Membrane Graft for Ocular Surface Reconstruction.

Am J Ophthalmol 2018 Oct 9. Epub 2018 Oct 9.

The New York Eye Cancer Center, Suite 5A/B, 115 East 61st Street, New York City, New York, USA 10065.

Purpose: Evaluate Super-Thick Amniotic Membrane Graft(ST-AMG) for ocular surface reconstruction.

Design: Retrospective, interventional case series.

Methods: SETTING: Single center, clinical practice POPULATION: Selected patients with typically large ocular surface abnormalities that required reconstruction. Read More

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October 2018
2 Reads

A Case Report of Recurrent Metastatic Sebaceous Carcinoma Which Showed Favorable Response Tt Non-Fluorouracil Based Chemotherapy.

Am J Case Rep 2018 Oct 6;19:1192-1196. Epub 2018 Oct 6.

Division of Hematology-Oncology, Department of Internal Medicine, Daejeon Sun Medical Center,, Daejeon, South Korea.

BACKGROUND Sebaceous carcinoma is a rare malignant tumor of the skin adnexa. While surgical resection is a treatment of choice in localized disease, frequent recurrence and distant metastasis make treatment difficult. Moreover, due to its rarity, optimal systemic treatment has not been determined. Read More

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October 2018
2 Reads

Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris.

Microbiome 2018 Oct 2;6(1):177. Epub 2018 Oct 2.

Department of Dermatology, University of California San Diego, La Jolla, CA, 92037, USA.

Acne is one of the most common skin diseases worldwide and results in major health care costs and significant morbidity to severely affected individuals. However, the pathophysiology of this disorder is not well understood. Host-microbiome interactions that affect both innate and adaptive immune homeostasis appear to be a central factor in this disease, with recent observations suggesting that the composition and activities of the microbiota in acne is perturbed. Read More

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October 2018
4 Reads

Differential expression of mTOR signaling pathway proteins in lichen planopilaris and frontal fibrosing alopecia.

Acta Histochem 2018 Nov 29;120(8):837-845. Epub 2018 Sep 29.

Charité-Universitätsmedizin, Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Berlin, Germany.

Dysregulation of the mammalian target of rapamycin (mTOR) signaling pathway has a variety of effects on the immune system and stem cell proliferation. Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are inflammatory scalp conditions resulting in permanent alopecia, which are thought to be related to stem cell damage. Here we investigate the expression of mTOR signaling pathway proteins in human hair follicles of LPP and FFA patients. Read More

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November 2018
1 Read

Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature.

PLoS One 2018 28;13(9):e0203672. Epub 2018 Sep 28.

The Rockefeller University, New York, New York, United States of America.

Hidradenitis suppurativa (HS) is a chronic skin disease of the pilo-sebaceous apocrine unit characterized by significant inflammation and an impaired quality of life. The pathogenesis of HS remains unclear. To determine the HS skin and blood transcriptomes and HS blood proteome, patient data from previously published studies were analysed and integrated from a cohort of patients with moderate to severe HS (n = 17) compared to healthy volunteers (n = 10). Read More

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September 2018

Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis.

Biomater Sci 2018 Nov 27;6(11):2859-2870. Epub 2018 Sep 27.

Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. and Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Full-thickness skin injury affects millions of people worldwide each year. It often leads to scar formation and loss of skin appendages even after clinical treatment. The majority of wound dressings currently used cannot achieve scarless skin regeneration with complete recovery of appendages such as hair follicles and sebaceous glands. Read More

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November 2018
2 Reads

Appearance of Verruca Over Linear Verrucous Epidermal Nevus - An Example of Locus Minoris Resistentiae: A Report of Three Cases.

Indian Dermatol Online J 2018 Sep-Oct;9(5):334-337

Department of Pathology, JSS Medical College and Hospital, JSS University, Mysuru, Karnataka, India.

Locus minoris resistentiae (LMR) is a site of the body that offers lesser resistance than the rest of the body to the onset of disease. It can be congenital or acquired. Areas of cutaneous mosaicism such as epidermal nevi can act as congenital LMR, leading to the development of inflammatory skin conditions or skin tumors on these. Read More

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September 2018
2 Reads

Caruncular Oncocytoma: Report of Two Cases with Review of Literature.

Indian Dermatol Online J 2018 Sep-Oct;9(5):324-327

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Caruncular lesions are uncommon and could be related to hair follicles, sebaceous glands, sweat glands, and accessory lacrimal gland harbored in caruncle. As the lesions of caruncle are diverse, the clinical diagnosis is difficult. Majority of the caruncular lesions are benign although rare malignant lesions have also been reported. Read More

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September 2018
1 Read

Follicle and Sebaceous Gland Multinucleated Cells in Measles.

Am J Dermatopathol 2018 Sep 24. Epub 2018 Sep 24.

Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.

We report the case of a 32-year-old man with measles in which skin biopsy helped to establish a definitive diagnosis. Follicular involvement is a common histopathologic feature of measles. Multinucleated epidermal and follicular cells are distinctive findings. Read More

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September 2018
4 Reads