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    Increasing ascorbate levels in crops to enhance human nutrition and plant abiotic stress tolerance.
    Curr Opin Biotechnol 2017 Feb 20;44:153-160. Epub 2017 Feb 20.
    Queensland University of Technology, Centre for Tropical Crops and Biocommodities, Institute for Future Environments, GPO Box 2434, Brisbane, QLD 4001, Australia.
    Ascorbate (or vitamin C) is an essential human micronutrient predominantly obtained from plants. In addition to preventing scurvy, it is now known to have broader roles in human health, for example as a cofactor for enzymes involved in epigenetic programming and as regulator of cellular iron uptake. Furthermore, ascorbate is the major antioxidant in plants and underpins many environmentally induced abiotic stress responses. Read More

    Headband sign on magnetic resonance imaging: An unusual finding of scurvy in a 5-year-old child described first time.
    J Pediatr Neurosci 2016 Oct-Dec;11(4):355-357
    Department of Pediatrics, Sir T Hospital, Bhavnagar, Gujarat, India.
    Scurvy usually presents with tender and painful limbs, swelling of joints, gum bleeding, poor wound healing, and muscle weakness. Here, we report a case of 5-year-old child with global developmental delay who presented with soft swelling of the head over scalp and protrusion of the left eye with extremely irritability. Neuroimaging was suggestive of diffuse extensive soft-tissue swelling involving the entire scalp with large necrotic collections with mild proptosis of the left orbit. Read More

    High Performance Liquid Chromatography-Diode Array Detector Method for the Simultaneous Determination of Five Compounds in the Pulp and Seed of Sea Buckthorn.
    Pharmacogn Mag 2017 Jan-Mar;13(49):136-140
    Central Laboratory of Xinjiang Medical University, Urumqi, Xinjiang, China.
    Context: Sea buckthorn (Hippophae rhamnoides L.) as a traditional Chinese medicinal plant has various uses in Xinjiang.

    Objective: A reversed-phase rapid-resolution liquid-chromatography method with diode array detector was developed for simultaneous determination of protocatechuic acid, rutin, quercetin, kaempferol, and isorhamnetin in the pulp and seed of sea buckthorn, a widely used traditional Chinese medicine for promoting metabolism and treating scurvy and other diseases. Read More

    Crude extract and solvent fractions of Calystegia soldanella induce G1 and S phase arrest of the cell cycle in HepG2 cells.
    Int J Oncol 2017 Feb 2;50(2):414-420. Epub 2017 Jan 2.
    Institute of Fisheries Science, Pukyong National University, Ilgwang-myeon, Gijang-gun, Busan 619-911, Republic of Korea.
    The representative halophyte Calystegia soldanella (L) Roem. et Schult is a perennial vine herb that grows in coastal dunes throughout South Korea as well as in other regions around the world. This plant has long been used as an edible and medicinal herb to cure rheumatic arthritis, sore throat, dropsy, and scurvy. Read More

    Insights gained from ancient biomolecules into past and present tuberculosis-a personal perspective.
    Int J Infect Dis 2016 Nov 30. Epub 2016 Nov 30.
    Centre for Clinical Microbiology, Division of Infection and Immunity, Royal Free Campus, University College London, London NW3 2PF, UK. Electronic address:
    Ancient and historical tuberculosis (TB) can be recognized by its typical paleopathology in human remains. Using paleomicrobiology, it is possible to detect many more individuals infected with TB but with no visible lesions. Due to advances in molecular analysis over the past two decades, it is clear that TB was widespread in humans from the Neolithic period and has remained so until the present day. Read More

    Systematic reviews in context: highlighting systematic reviews relevant to Africa in the Pan African Medical Journal.
    Pan Afr Med J 2016 30;24:180. Epub 2016 Jun 30.
    The Pan African Medical Journal, Center for Public Health Research and Information, Nairobi, Kenya.
    Health research serves to answer questions concerning health and to accumulate facts (evidence) required to guide healthcare policy and practice. However, research designs vary and different types of healthcare questions are best answered by different study designs. For example, qualitative studies are best suited for answering questions about experiences and meaning; cross-sectional studies for questions concerning prevalence; cohort studies for questions regarding incidence and prognosis; and randomised controlled trials for questions on prevention and treatment. Read More

    Modern American scurvy - experience with vitamin C deficiency at a large children's hospital.
    Pediatr Radiol 2017 Feb 24;47(2):214-220. Epub 2016 Oct 24.
    Department of Radiology, Texas Children's Hospital, 6701 Fannin St., Suite 470, Houston, TX, 77030, USA.
    Background: Until recently scurvy has been viewed in developed countries as a disease of the past. More recently there have been reports of case series of children with scurvy who have had a delayed diagnosis after an extensive diagnostic workup that included imaging. Most of these children have had underlying neurologic conditions such as autism. Read More

    Gingival Bleeding and Bloody Dialysate: A Case Report of Scurvy in a Child With End-Stage Renal Disease Receiving Peritoneal Dialysis.
    J Ren Nutr 2016 Nov 23;26(6):407-411. Epub 2016 Apr 23.
    Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
    Patients with chronic kidney disease (CKD) or end-stage renal disease are at risk for vitamin C deficiency and scurvy due to diet restriction, increased urinary loss of the water-soluble vitamin C with diuretics, and in case of patients who are on dialysis, through dialysates. The condition may be overlooked as the clinical manifestation of scurvy may be subtle, and some presentations may mimic clinical signs in CKD. We reported a case of scurvy presenting with gingival bleeding and blood dialysate in a 6-year-old girl with end-stage renal disease who was on continuous ambulatory peritoneal dialysis. Read More

    Imaging Findings of Metabolic Bone Disease.
    Radiographics 2016 Oct;36(6):1871-1887
    From the Division of Musculoskeletal Imaging and Intervention, Department of Radiology (C.Y.C., D.I.R., S.V.K., A.J.H.), and the Pediatric Endocrine Division, Department of Pediatrics (D.M.M.), Massachusetts General Hospital, 55 Fruit St, Yawkey 6E, Boston, MA 02114; and the Department of Radiology, St. Luke's International Hospital, Tokyo, Japan (A.H.).
    Metabolic bone diseases are a diverse group of diseases that result in abnormalities of (a) bone mass, (b) structure mineral homeostasis, (c) bone turnover, or (d) growth. Osteoporosis, the most common metabolic bone disease, results in generalized loss of bone mass and deterioration in the bone microarchitecture. Impaired chondrocyte development and failure to mineralize growth plate cartilage in rickets lead to widened growth plates and frayed metaphyses at sites of greatest growth. Read More

    Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies.
    Int J Mol Sci 2016 Aug 12;17(8). Epub 2016 Aug 12.
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
    Vitamin C is a powerful dietary antioxidant that has received considerable attention in the literature related to its possible role in heart health. Although classical vitamin C deficiency, marked by scurvy, is rare in most parts of the world, some research has shown variable heart disease risks depending on plasma vitamin C concentration, even within the normal range. Furthermore, other studies have suggested possible heart-related benefits to vitamin C taken in doses beyond the minimal amounts required to prevent classically defined deficiency. Read More

    [Atypical scurvy associated with anorexia nervosa].
    Ann Dermatol Venereol 2017 Feb 5;144(2):125-129. Epub 2016 Aug 5.
    Service de médecine interne générale, hôpitaux universitaires de Genève, 1206 Genève, Suisse; Service de médecine interne, hôpital de la Tour, 1217 Meyrin-Genève, Suisse.
    Introduction: Scurvy, or "Barlow's disease", is a widely described disease involving cutaneous and mucosal lesions resulting from vitamin C deficiency. Herein, we report a case of scurvy in a 48-year-old woman that was unusual in its atypical cutaneous-mucosal presentation as well as its association with anorexia nervosa.

    Patients And Methods: A 48-year-old woman treated for depression for several years was admitted to hospital for her impaired general state of health. Read More

    A Case of Scurvy-Uncommon Disease-Presenting as Panniculitis, Purpura, and Oligoarthritis.
    J Cutan Med Surg 2016 Nov 14;20(6):592-595. Epub 2016 Jul 14.
    Division of Dermatology, Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada
    Importance: Scurvy remains prevalent in certain populations, including addicts, people of low socioeconomic status, and the severely malnourished. It classically presents as follicular hyperkeratosis and perifollicular hemorrhage of the lower extremities, as well as bleeding in other areas such as the gingiva and joints. This case presentation and literature review highlights the common pathophysiological findings associated with scurvy and current methods of diagnosis and treatment. Read More

    History of health in the Indian Ocean: care, prevention, teaching, and research from the 17(th) to the mid-20th century.
    Med Sante Trop 2016 May;26(2):122-9
    Centre René Labusquière, université de Bordeaux, 33 076 Bordeaux cedex, France, Service de réanimation polyvalente, CHU de La Réunion, hôpital Félix Guyon, 97405 Saint-Denis, France.
    In 1498, the Portuguese crossed the Cape of Good Hope. It was not until the period of 1633 and 1666, dates of the founding, respectively, of the Compagnie de l'Orient and the Compagnie des Indes orientales, that the way was definitively opened for trade between France and India. Because so many sailors developed scurvy after voyages that lasted 4 to 5 months, the French settled on Bourbon Island (Réunion) and Ile de France (Mauritius), to provide them with medical care. Read More

    Human Collagen Prolyl 4-Hydroxylase Is Activated by Ligands for Its Iron Center.
    Biochemistry 2016 Jun 31;55(23):3224-33. Epub 2016 May 31.
    Department of Biochemistry and ‡Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
    Collagen is the most abundant protein in animals. The posttranslational hydroxylation of proline residues in collagen contributes greatly to its conformational stability. Deficient hydroxylation is associated with a variety of disease states, including scurvy. Read More

    Now you see/C it.
    Postgrad Med 2016 Aug 8;128(6):629-31. Epub 2016 Jun 8.
    a Yale University School of Medicine , New Haven , CT , USA.
    Bleeding disorders are common. In addition to thinking about disorders relating to abnormal platelets or clotting factors, clinicians should consider disorders of vascular integrity in their differential diagnosis. We present a patient with atypical, spontaneous bleeding that was due to scurvy, an often overlooked cause. Read More

    Lost at Sea in Search of a Diagnosis: A Case of Unexplained Bleeding.
    Pediatr Blood Cancer 2016 Jul 8;63(7):1305-6. Epub 2016 Apr 8.
    Division of Pediatric Rheumatology, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan.
    Scurvy results from a dietary deficiency of vitamin C (ascorbic acid) and is rarely thought of in modern day medicine. It now almost always occurs in pediatric patients with behavioral diagnoses, nutritionally restricted diets, and food allergies. Symptoms of scurvy include ecchymoses, bleeding gums, and arthralgias. Read More

    CLINICAL PROBLEM-SOLVING. A Deficient Diagnosis.
    N Engl J Med 2016 Apr;374(14):1369-74
    From the Departments of Internal Medicine (D.H., S.S., J.M.), Pediatrics (D.H., R.M., J.M.), and Radiology (J.G.) and the Robert Wood Johnson Clinical Scholars Program (D.H.), University of Michigan, and the Veterans Affairs Ann Arbor Healthcare System (D.H., S.S., J.M.) - both in Ann Arbor.

    Scurvy in the present times: vitamin C allergy leading to strict fast food diet.
    Dermatol Online J 2016 Jan 15;22(1). Epub 2016 Jan 15.
    Massachusetts General Hospital.
    Scurvy results from a deficiency of vitamin C, a nutrient otherwise known as ascorbic acid. Today, scurvy is rare yet emerges in select patients. The patient reported herein developed scurvy secondary to deliberate avoidance of vitamin C-rich foods. Read More

    The epigenetic role of vitamin C in health and disease.
    Cell Mol Life Sci 2016 Apr 4;73(8):1645-58. Epub 2016 Feb 4.
    John P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Biomedical Research Building, Rm. 608, 1501 NW 10th Ave, Miami, FL, 33136, USA.
    Recent advances have uncovered a previously unknown function of vitamin C in epigenetic regulation. Vitamin C exists predominantly as an ascorbate anion under physiological pH conditions. Ascorbate was discovered as a cofactor for methylcytosine dioxygenases that are responsible for DNA demethylation, and also as a likely cofactor for some JmjC domain-containing histone demethylases that catalyze histone demethylation. Read More

    Arterial Tortuosity Syndrome reveals function of dehydroascorbic acid in collagen and elastin synthesis: Implications for skin care.
    Med Hypotheses 2016 Feb 17;87:8-9. Epub 2015 Dec 17.
    ReCverin LLC, 944 E. 3300 S., Salt Lake City, UT 84106, United States. Electronic address:
    Some investigations in Arterial Tortuosity Syndrome (ATS) suggest that impaired intracellular transport of the oxidized form of vitamin C (dehydroascorbic acid, DHAA) is at the core of the pathogenesis. Lack of vitamin C for lysyl- and prolyl-hydroxylase activity may explain the defects in collagen and elastin formation found in ATS, and draws strong parallels between ATS and scurvy. Topically applied vitamin C has a well-established basis in the field of skin care, and part of its benefit is attributed to proper collagen formation in the skin. Read More

    Assessment of diet and recognition of nutritional deficiencies in paleopathological studies: A review.
    Clin Anat 2016 Oct 17;29(7):862-9. Epub 2016 Feb 17.
    Department of Anatomy, School of Medicine, Faculty of Health Sciences, University of Pretoria, Arcadia, Gauteng, South Africa.
    An essential part of paleopathology is the study of diet and nutrition as well as inferring aspects of diet and nutrition from the skeletal pathology. Interpretation of nutritional and metabolic disease-related pathologies often provides additional insight into the daily social and cultural practices of people. However, precise diagnoses of specific vitamin-related deficiencies in archaeological skeletal remains are still quite problematic and specific diagnoses are rarely possible. Read More

    Vitamin C: the known and the unknown and Goldilocks.
    Oral Dis 2016 Sep 14;22(6):463-93. Epub 2016 Apr 14.
    Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
    Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts as a cofactor for fifteen mammalian enzymes. Two sodium-dependent transporters are specific for ascorbic acid, and its oxidation product dehydroascorbic acid is transported by glucose transporters. Read More

    Improper Use of a Plant-Based Vitamin C-Deficient Beverage Causes Scurvy in an Infant.
    Pediatrics 2016 Feb 18;137(2):e20152781. Epub 2016 Jan 18.
    Hospital Universitario y Politécnico La Fe, Valencia, Spain; and.
    Scurvy is a rare disease in developed countries. Risk groups include children with restricted diets, mainly patients who are autistic or have cerebral palsy. Furthermore, consumption of plant-based beverages has increased in recent years, especially in developed countries. Read More

    [Scurvy. A rare differential diagnosis of rheumatic diseases].
    Z Rheumatol 2016 Mar;75(2):166-72
    Universitätsklinik für Innere Medizin 3, Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland.
    Background: In December 2014 a patient presented to our clinic with the clinical symptoms of vasculitis. However, treatment with glucocorticoids did not lead to any improvement; therefore, the differential diagnostics were extended to other indications and ultimately led to the diagnosis of scurvy.

    Objective: This article describes the clinical picture of scurvy and its relationship to rheumatic diseases based on a clinical case and additional information from the literature. Read More

    Modern scurvy.
    J Surg Case Rep 2016 Jan 10;2016(1). Epub 2016 Jan 10.
    Department of Surgery, Medisch Centrum Leeuwarden, Leeuwarden 8934 AD, The Netherlands.
    Scurvy is a disease that played an important role in ancient history and used to be a notorious cause of death in sailors. Nowadays, scurvy is not a common diagnosis in the civilized world, but this case report indicates that this old-fashioned disease is not extinct at all and still exists but in a different patient category. Read More

    Brief Report: Scurvy as a Manifestation of Food Selectivity in Children with Autism.
    J Autism Dev Disord 2016 Apr;46(4):1464-70
    Center for Nutrition, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.
    Scurvy was diagnosed in seven children at Boston Children's Hospital. All of the children had a developmental disorder and autism was the most common. They had a long-standing history of food selectivity with diets devoid of fruits and vegetables, and none of the children were supplemented with a multivitamin. Read More

    Traumatic Injury in a Child with Scurvy: A Case Report.
    J Med Assoc Thai 2015 Sep;98 Suppl 8:S95-101
    This case report aimed to describe the clinical presentation, treatments and prognosis of a child who had scurvy and traumatic injury of the left thigh. A 30-month-old boy had presented with left hip pain two weeks after falling down on the floor while walking. He developed pain, warmness of the left hip and thigh, and finally was unable to bear weight. Read More

    Electrochemical impedance based chiral analysis of anti-ascorbutic drug: l-Ascorbic acid and d-ascorbic acid using C-dots decorated conductive polymer nano-composite electrode.
    Biosens Bioelectron 2016 Mar 22;77:715-24. Epub 2015 Oct 22.
    Complex Systems Group, Department of Chemistry, University of Delhi, Delhi 110007, India. Electronic address:
    Clinical manifestations owing to l-ascorbic acid for scurvy as comparison to d-ascorbic acid and challenges of chiral purity are overcome by using chiral selective conductive polymer nanocomposite which mimics antibodies and enzymes. A novel chiral selective imprinted polyaniline-ferrocene-sulfonic acid film has been electrochemically fabricated on C-dots modified pencil graphite electrode. The performance of the obtained l-ascorbic acid or d-ascorbic acid chiral selective sensor was investigated by electrochemical impedance spectroscopy, cyclic and differential pulse voltammetry. Read More

    Hypocholesterolemic Efficacy of Quercetin Rich Onion Juice in Healthy Mild Hypercholesterolemic Adults: A Pilot Study.
    Plant Foods Hum Nutr 2015 Dec;70(4):395-400
    School of Nutrition, Chung Shan Medical University, No. 110, Sec.1, Jianguo N. Rd, Taichung City, 40201, Taiwan, Republic of China.
    Onion (Allium cepa L.) is widely employed as a food ingredient as well as traditional remedy to treat fever, burns, and scurvy. The present study focused on the modulator efficacy of the quercetin rich onion juice on lipid profile and antioxidant status in mildly hypercholesterolemic subjects. Read More

    From past sailors' eras to the present day: scurvy as a surprising manifestation of an uncommon gastrointestinal disease.
    BMJ Case Rep 2015 Sep 16;2015. Epub 2015 Sep 16.
    Department of Gastroenterology, Coimbra University Hospital, Coimbra, Portugal.
    A 45-year-old man presented with follicular exanthema in his lower limbs, alternating bowel habits and significant weight loss. His medical history included seronegative arthritis, bipolar disease and an inconclusive diagnostic laparoscopy. Diagnostic work up revealed microcytic anaemia and multivitamin deficiency. Read More

    [Infantile scurvy: Two cases].
    Ann Dermatol Venereol 2015 Nov 9;142(11):675-9. Epub 2015 Sep 9.
    Service de pédiatrie, immuno-hématologie et oncologie pédiatrique, hôpital Nord, centre hospitalo-universitaire de Saint-Étienne, 42055 Saint-Étienne cedex 02, France.
    Background: Scurvy is the classic and most severe form of vitamin C deficiency. This condition has become extremely rare among children in the industrialized countries.

    Patients And Methods: We report the case of two boys presenting bone pain associated with haemorrhagic gingivitis, with perifollicular purpura of the lower limbs in one boy. Read More

    The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments.
    J Bone Miner Res 2015 Nov 7;30(11):1945-55. Epub 2015 Oct 7.
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, CA, USA.
    Vitamin C is an important antioxidant and cofactor that is involved in the regulation of development, function, and maintenance of several cell types in the body. Deficiencies in vitamin C can lead to conditions such as scurvy, which, among other ailments, causes gingivia, bone pain, and impaired wound healing. This review examines the functional importance of vitamin C as it relates to the development and maintenance of bone tissues. Read More

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