2,622 results match your criteria Scurvy
Acta Med Hist Adriat 2018 Dec;16(2):203-238
Clinical pathology, Stedelijk Ziekenhuis, Roeselare, Belgium.
A discussion is given of the figure of Johann Bachoven von Echt and his family, and on his work on scurvy. The disease is evaluated as a possible cause of the death of Andreas Vesalius. Echt's relationship with Jan Wier and his connections with Vesalius and Metellus are illustrated. Read More
Nutr Metab Insights 2018 21;11:1178638818809097. Epub 2018 Nov 21.
Department of Geriatric Medicine, Karin Grech Hospital, Pietà, Malta.
Background And Objective: Scurvy, caused by vitamin C deficiency, first described by Hippocrates, is known to many as 'The Pirates' Disease'. Although a disease rarely acknowledged in modern medicine, we present 2 cases of elderly gentlemen found to have scurvy, who improved significantly on treatment.
Methods: This study presents a case report of 2 patients undergoing rehabilitation at Karin Grech Hospital in Malta, noted to have signs and symptoms of vitamin C deficiency. Read More
Pediatr Emerg Care 2018 Nov 19. Epub 2018 Nov 19.
From the Department of Emergency Medicine (Pediatric Unit), College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Ketogenic diets used for treating various neurological disorders can have potentially serious adverse effects. Among these is scurvy, a rarely reported, yet potentially fatal adverse effect of the ketogenic diet caused by vitamin C deficiency. We report a case of a 5-year-old patient with autism, who presented with scurvy secondary to the dietary restrictions of a ketogenic diet. Read More
Afr J Prim Health Care Fam Med 2018 Oct 25;10(1):e1-e3. Epub 2018 Oct 25.
Family Medicine Department, Africa Inland Church, Kijabe Hospital.
Over a five-month period, clinicians in Tana River County Kenya observed an increasing number of patients presenting to health facilities with a common collection of symptoms including fevers, joint pains and gum hypertrophy. After initial investigative and management strategies failed to reveal a diagnosis, patients were empirically commenced on ascorbic acid for presumed scurvy. This strategy resulted in the rapid resolution of symptoms in 65 patients within two weeks. Read More
Vet Clin North Am Exot Anim Pract 2019 Jan;22(1):15-26
Ophthalmology, BluePearl Veterinary Partners, 1071 Howell Mill Road Northwest, Atlanta, GA 30318, USA. Electronic address:
This article discusses the clinical appearance, differential diagnoses, and treatment considerations of corneal disease in the most common domesticated species of rodent: mouse, rat, chinchilla, and guinea pig. Many corneal diseases are related to inbred strains of either research or pet rodents. Diseases are complicated by husbandry and treatment-related challenges in this small, social species. Read More
Rev Med Liege 2018 Nov;73(11):541-543
Gastro-entérologie, CHBA, Liège, Belgique.
Scurvy, a disease caused by a deficit in vitamin C, is again described in Europe nowadays. This condition is associated with poverty and malnutrition, as found in developing countries. However, denutrition may also occur with a "western" lifestyle that can lead to nutriment deficiencies. Read More
Am J Forensic Med Pathol 2018 Nov 12. Epub 2018 Nov 12.
School of Humanities, University of Tasmania, Hobart, Tasmania, Australia.
Scurvy is a multisystem condition that arises from vitamin C deficiency. As humans cannot synthesize vitamin C, serum and tissue levels depend on bioavailability, utilization, and renal excretion. Deficiencies result in defective collagen formation with swelling of gums, leg ulceration, and bleeding manifestations. Read More
Hemodial Int 2018 Nov 8. Epub 2018 Nov 8.
Division of Nephrology, Department of Medicine, University of Missouri, CE425, 1 Hospital Drive, Columbia, Missouri 65212, USA.
Chronic kidney disease and dialysis brings with it a plethora of complications, including malnutrition. Strict dietary restrictions in hemodialysis (HD) patients further complicate the picture as it increases the risk of deficiency of micronutrients, specifically water-soluble vitamins. Today, there is a lack of concrete guidelines concerning recommendations on vitamin supplementation in HD patients. Read More
Skeletal Radiol 2018 Oct 29. Epub 2018 Oct 29.
Department of Radiology, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland.
Scurvy is a disease that is rarely encountered in modern medicine. A condition that was classically associated with sailors, its incidence has decreased dramatically since the discovery of its association with vitamin C deficiency. We present the case of a 2-year-old boy, whose treatment for neuroblastoma was complicated by gastrointestinal disease, which necessitated enteral feeding. Read More
Pulm Circ 2018 Oct 23:2045894018812052. Epub 2018 Oct 23.
UCSF Benioff Children's Hospital Oakland.
Sci Pharm 2018 Oct 7;86(4). Epub 2018 Oct 7.
Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, 11931 Amman, Jordan.
Mediterranean-native perennial plant was scrutinized in this study for its antioxidant activity and its total phenolic content in order to test for the plant's wound-healing capability. The traditional uses of this plant to treat gum scurvy, various tumors, ulcers, and hemorrhoids were the main idea behind this study. Leaves and flowers of the were extracted by maceration. Read More
Am J Phys Anthropol 2018 Dec 9;167(4):876-895. Epub 2018 Oct 9.
Department of Anatomy, University of Otago, Dunedin, Otago, New Zealand.
The past two decades have seen a proliferation in bioarchaeological literature on the identification of scurvy, a disease caused by chronic vitamin C deficiency, in ancient human remains. This condition is one of the few nutritional deficiencies that can result in diagnostic osseous lesions. Scurvy is associated with low dietary diversity and its identification in human skeletal remains can provide important contextual information on subsistence strategy, resource allocation, and human-environmental interactions in past populations. Read More
Skeletal Radiol 2018 Sep 26. Epub 2018 Sep 26.
Department of Radiology, Penn State Milton S. Hershey Medical Center, 500 University Dr, Hershey, PA, 17033, USA.
A 69-year-old man presented with unilateral calf pain, swelling, and erythematous rash. He was initially treated with antibiotics for suspected cellulitis. A venous duplex ultrasound, performed to exclude deep venous thrombosis, revealed multiple heterogeneous hypoechoic foci of unknown etiology throughout the calf musculature. Read More
Homo 2018 Sep 5;69(5):217-226. Epub 2018 Sep 5.
Institute for Anthropological Research, Zagreb 10 000, Croatia.
In this study, we examine the scurvy associated skeletal lesions among juveniles from the late Medieval site Uzdolje-Grablje in Croatia. The study aims to establish a demographic pattern of scurvy using existing diagnostic criteria. The sample consists of 16 well-preserved and fairly complete juveniles, excavated from a cemetery dating to 1420-1920. Read More
Arch Argent Pediatr 2018 Oct;116(5):e684-e687
Departamento de Pediatría, Servicio de Clínica Pediátrica, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires.
Scurvy is a very uncommon entity in pediatric population. Some case reports have been published in infants fed with boiled milk, in patients with iron overload secondary to hematological diseases and in children with food restrictions secondary to neurodevelopmental disorders. We report a case of a 4-year-old male patient with a diagnosis of autism spectrum disorder, which developed scurvy secondary to a long-term selective eating habit without fruit or vegetable intake. Read More
Pathology 2018 Oct 31;50(6):654-658. Epub 2018 Aug 31.
Department of Surgery, Liverpool Hospital, Sydney, NSW, Australia; Faculty of Medicine, Department of Surgery, University of New South Wales, Sydney, NSW, Australia.
Vitamin C is an essential micronutrient in the human diet. While large population studies measuring vitamin C have been performed in other countries, there are few studies of deficiency in the Australian population. This study aimed to quantify vitamin C deficiency, identify scorbutic symptoms and examine dietary associations in a cohort of preoperative general surgical patients. Read More
Lancet 2018 08;392(10145):431
Department of Dermatology, Weill Cornell Medical School, New York, NY, USA. Electronic address:
Arch Dis Child 2018 Aug 7. Epub 2018 Aug 7.
General Pediatric and Infectious Disease Unit, University Department of Pediatrics, Bambino Gesù Children's Hospital, Rome, Italy.
We report three cases of scurvy in previously healthy children referred to us for leg pain and refusal to walk. All children had no significant medical history, symptoms had started months before and subtly advanced. Two of them presented with gingival hyperplasia and petechiae, another one reported night sweats and gingival bleeding in the past few weeks. Read More
Int J Paleopathol 2018 Sep 31;22:121-134. Epub 2018 Jul 31.
University of Fribourg, Institut du monde antique et byzantin, Rue P. Aeby 16, 1700, Fribourg, Switzerland; Hellenic Ministry of Culture, Ephorate of Antiquities of Chania, Sourmeli 24, 73132, Chania, Greece. Electronic address:
The study of Roman childhood has been the focus of research primarily using documentary and archaeological evidence, while relatively few non-adult skeletal assemblages have been analyzed. This paper presents the study of 93 non-adult individuals from four cemeteries in the Roman (1st-3rd c. CE) civitas capital of Aventicum (Avenches), Switzerland. Read More
Eur J Rheumatol 2018 Dec 13;5(4):283-284. Epub 2018 Feb 13.
Department of Pediatric Hematology, Erciyes University School of Medicine, Kayseri, Turkey.
Pediatrics 2018 Aug;142(2)
Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Historically linked to sea voyagers in the 18th century, scurvy has become extremely rare during the last century in developed countries. However, it is still present in some at-risk populations and often overlooked in pediatric patients with restricted diets due to behavioral, neurodevelopmental, or psychiatric problems. So far, the only known etiology of developing scurvy is nutritional deficiency of vitamin C. Read More
J Gen Intern Med 2018 Nov 27;33(11):2008-2009. Epub 2018 Jul 27.
Division of General Internal Medicine & Geriatrics, Oregon Health & Science University, Portland, OR, USA.
Eur Rev Med Pharmacol Sci 2018 Jul;22(13):4355-4358
Institute of Internal Medicine, Catholic University of the Sacred Heart, A. Gemelli, Hospital Foundation, School of Medicine, Rome, Italy.
Objective: Scurvy is defined as a deficiency of ascorbic acid, which is an essential exogenous vitamin in humans. Vitamin C is involved in collagen synthesis and its deficit can cause disorders of connective tissue. The most frequent symptoms are weakness, arthralgias, anorexia and depression, commonly associated with follicular hyperkeratosis and perifollicular hemorrhage, with purpura. Read More
N Engl J Med 2018 Jul;379(3):282-289
From the Departments of Medicine (S.E.B., W.P.S., F.C.S.), Pediatrics (F.C.S.), and Pathology (J.M.B.), Massachusetts General Hospital, and the Departments of Medicine (S.E.B., W.P.S., F.C.S.), Pediatrics (F.C.S.), and Pathology (J.M.B.), Harvard Medical School - both in Boston.
J Paediatr Child Health 2018 Dec 27;54(12):1375-1377. Epub 2018 Jun 27.
Department of Radiology, Sunshine Hospital, Melbourne, Victoria, Australia.
Fertil Steril 2018 Jun;109(6):988
Division of Reproductive Endocrinology and Infertility, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
J Periodontol 2018 Jun;89 Suppl 1:S74-S84
Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77
Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More
J Clin Psychopharmacol 2018 08;38(4):398-400
Department of Psychiatry Bicêtre University Hospital and Assistance Publique-Hôpitaux de Paris Le Kremlin Bicêtre, France Service d'Hématologie Biologique CHU BicêtreAssistance Publique-Hôpitaux de Paris INSERM UMR_S1176 Université Paris-Sud Université Paris-Saclay, Le Kremlin-BicêtreCentre de Référence de la Maladie de Willebrandand Centre de Référence des Pathologies Plaquettaires, France Department of Internal MedicineBicêtre University Hospital Assistance Publique-Hôpitaux de Paris Université Paris-Sud, Le Kremlin-BicêtreINSERM UMR 1184Immunologie des Maladies Virales et AutoimmunesUniversité Paris-Sud, Le Kremlin Bicêtreand CEA, DSV/iMETIDivision of Immuno-Virology IDMIT Paris, France Department of Psychiatry Bicêtre University Hospital and Assistance Publique-Hôpitaux de Paris Le Kremlin BicêtreCHU de Bicêtre, Université Paris-Saclay Université Paris-Sud; UVSQCESP; INSERM U1178Le Kremlin Bicêtre, France
Clin Pract Cases Emerg Med 2018 May 14;2(2):147-150. Epub 2018 Mar 14.
Wake Forest School of Medicine, Department of Emergency Medicine, Winston-Salem, North Carolina.
Although the causes have changed, scurvy (vitamin C deficiency) is still diagnosed in developed countries. We report a case of an 18-year-old female who presented to our emergency department with thrombocytopenia, sinus tachycardia, hypotension, fatigue, gingival hyperplasia, knee effusion, petechiae and ecchymosis in lower extremities. The differential diagnosis included hematologic abnormalities, infectious etiologies, vasculitis and vitamin deficiency. Read More
Front Pediatr 2018 1;6:126. Epub 2018 May 1.
Pediatric Department, University of Florence, Anna Meyer Children Hospital, Florence, Italy.
Vitamin C deficiency is anecdotal in developed countries, mainly associated with underling clinical morbidities as autism or neurological impairment. Chronic insufficient dietary supply is responsible for vascular fragility and impaired bone formation, resulting in gingival bleeding, petechial lesions, articular and bone pain or limb swelling. Children may present anorexia, irritability, failure to thrive, limping or refusal to walk. Read More
Proc (Bayl Univ Med Cent) 2018 Apr 12;31(2):227-228. Epub 2018 Mar 12.
Department of Hematology and Oncology, Utica Park Clinic Oncology, Tulsa, Oklahoma.
Vitamin C deficiency may be common in third-world countries due to malnutrition, but it is currently rare in the USA. Initially, nonspecific symptoms like exhaustion and depression may make this disease difficult to diagnose until classical dermatological manifestations appear. Diagnosis mainly relies on clinical presentation, dietary history to identify risk factors, and dramatic recession of symptoms and signs following vitamin C therapy. Read More
J Dent Child (Chic) 2018 Jan;85(1):40-42
Department of Oral Pathology, Nair Hospital Dental College, Mumbai, India.
Localized gingival enlargement associated with vitamin C deficiency (scurvy) is rarely encountered in the modern era. The purpose of this paper is to report a case of extensive inflammatory gingival enlargement in the mandibular anterior region associated with vitamin C deficiency in a 10 year-old boy. There was a significant improvement of the gingival enlargement seven days after starting oral vitamin C supplementation. Read More
Clin Med (Lond) 2018 Mar;18(2):180-182
Northwick Park Hospital, London, UK
A 73-year-old man presented with bilateral leg pain and swelling, and no history of trauma or bleeding disorders. Clinical examination, biochemistry and magnetic resonance imaging of the thighs were suggestive of muscle haematomas. These progressed significantly during the admission, requiring blood transfusion. Read More
BMJ Case Rep 2018 Mar 30;2018. Epub 2018 Mar 30.
Department of Intensive Care, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina.
Scurvy is a nutritional disease caused by ascorbic acid deficiency and is potentially fatal. It was originally described in the 18th century by James Lind and associated with long sea voyages and insufficient citrus consumption. Its prevalence has declined markedly over the years but has still been described sporadically in certain countries. Read More
Case Rep Nephrol Dial 2017 Sep-Dec;7(3):172-177. Epub 2017 Dec 22.
Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
This case describes an obese adult male peritoneal dialysis patient who presented with a pruritic follicular rash. Nutrient deficiency was not suspected initially in this case because there was no history of protein-calorie malnutrition, but the patient reported a diet devoid of fruits and vegetables and had not been taking his dialysis vitamin as prescribed. Skin biopsy showed follicular hyperkeratosis with fragmented hair shafts and corkscrew hairs consistent with scurvy. Read More
Anthropol Anz 2018 May;75(2):155-167
Anthropological Centre, Croatian Academy of Sciences and Arts, Zagreb, Croatia.
Abstract: Childhood stress, using both subadult and adult remains from early mediaeval (8-11 c. CE) sites on the eastern Adriatic coast is analysed in this report. A total of 242 individuals (83 subadults, 69 adult females, and 90 adult males) were assessed for the presence of linear enamel hypoplasia, cribra orbitalia, sub-periosteal new bone formation, and scurvy. Read More
J R Coll Physicians Edinb 2017 Dec;47(4):384-387
S Justman, University of Montana, 1703 Maurice Ave, Missoula, MT 59801, USA. Email:
Though James Lind is renowned as a pioneer of the clinical trial, he records the 1747 trial aboard the Salisbury in passing, never followed up on it, never campaigned for clinical trials as a means of medical discovery, and eventually pronounced scurvy an insoluble enigma. The case can be made that in confessing his lack of an unfailing remedy for scurvy and his trouble making sense of the disease's behaviour, Lind did medicine a greater service than by conducting his now-famous trial. At the time, medical progress was hindered by the all-too-common practice of proclaiming success and concealing failure. Read More
Int J Paleopathol 2018 Mar 17;20:116. Epub 2017 Oct 17.
Archaeological Sciences, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK. Electronic address:
Int J Paleopathol 2018 Mar 10;20:114-115. Epub 2017 Oct 10.
Laboratorio de Poblaciones del Pasado (LAPP), Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Campus de Cantoblanco, 28049 Madrid, Spain. Electronic address:
J Nutr 2018 02;148(2):167-169
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD.
Adv Food Nutr Res 2018;83:281-310. Epub 2018 Feb 16.
Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada. Electronic address:
Vitamin C is essential to prevent scurvy in humans and is implicated in the primary prevention of common and complex diseases such as coronary heart disease, stroke, and cancer. This chapter reviews the latest knowledge about dietary vitamin C in human health with an emphasis on studies of the molecular mechanisms of vitamin C maintenance as well as gene-nutrient interactions modifying these relationships. Epidemiological evidence indicates 5% prevalence for vitamin C deficiency and 13% prevalence for suboptimal status even in industrialized countries. Read More
Int J Infect Dis 2018 Apr 6;69:99-102. Epub 2018 Feb 6.
Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:
A case of scurvy in a 10-year-old boy with autism spectrum disorder is described. His clinical presentation was initially thought to be due to osteomyelitis, for which empirical antimicrobial therapy was initiated. Further invasive and ultimately unnecessary investigations were avoided when scurvy was considered in the context of a restricted diet and classic signs of vitamin C deficiency. Read More
Medicine (Baltimore) 2017 Nov;96(47):e8861
Rationale: Scurvy is often diagnosed at the state of well-established signs as, for example, skin and visceral purpura, gums involvement, loss of healthy teeth, which derive mostly from disturbance of collagen metabolism. Little is known about the state of latent scurvy, which symptoms are nonspecific and may mimic more common conditions such as weakness, leg pain, and muscle aching.
Patient Concerns: We report 3 cases of extreme lassitude and leg pain in alcoholics. Read More
Crit Care 2018 01 29;22(1):23. Epub 2018 Jan 29.
Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, 825 Fairfax Av, Suite 410, Norfolk, VA, 23507, USA.
Pediatr Emerg Care 2018 Jan 23. Epub 2018 Jan 23.
From the Departments of Emergency Medicine and Pediatrics, Children's Hospital of the King's Daughters, Norfolk, VA.
Scurvy in modern times may not be as rare as previously thought. The link between adequate intake of vitamin C and scurvy has been known since ancient times and is recorded in Ebers Papyrus. Recent reports indicate that, with restricted diets, vitamin C deficiency is being seen in infants exclusively fed plant-based formula and children with oral aversion, autism, restricted diets, and cerebral palsy. Read More
Uisahak 2017 Dec;26(3):503-544
This article demonstrates the medicinal usage of ginseng in the West from 1660 to 1914. Asian[Korea] ginseng was first introduced into England in the early 17th century, and North American ginseng was found in the early 18th century. Starting from the late 17th century doctors prescribed ginseng to cure many different kinds of ailments and disease such as: fatigue general lethargy, fever, torpidity, trembling in the joints, nervous disorder, laughing and crying hysteria, scurvy, spermatic vessel infection, jaundice, leprosy, dry gripes and constipation, strangury, yellow fever, dysentery, infertility and addictions of alcohol, opium and tobacco, etc. Read More