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QJM 2022 May 16. Epub 2022 May 16.

Department of Internal Medicine, St. Marianna University School of Medicine, Division of General Internal Medicine, Kawasaki, Kanagawa, Japan.

J Cutan Med Surg 2022 May 15:12034754221100193. Epub 2022 May 15.

19051 Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.

Soc Hist Med 2022 May 5;35(2):566-588. Epub 2021 Oct 5.

CAMPOP, Department of Geography, University of Cambridge, Downing Place, Cambridge, CB2 3EN, UK.

Seventeenth-century UK experienced an epidemic of the newly recognised disease rickets, its nutritional and environmental causes then unknown. This is evident from parish burial registers, the London Bills of Mortality, and contemporary medical descriptions and treatments. Rickets appeared to be killing 2-8 per cent of urbanites, especially wealthy children. Read More

Arch Argent Pediatr 2022 Jun;120(3):e137-e141

Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina.

Scurvy is a disease caused by vitamin C deficiency. Although it is currently rare, risk groups in the pediatric population are described in the bibliography, including patients with eating disorders. We report the case of an 11-year-old male adolescent who developed the disease due to a selective eating habit, without fruits or vegetables. Read More

Front Pediatr 2022 13;10:871993. Epub 2022 Apr 13.

Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, United States.

Chronic non-infectious osteomyelitis (CNO) is a rare, inflammatory process associated with pediatric inflammatory bowel disease (IBD). Signs and symptoms of CNO parallel scurvy, a nutritional deficiency that can affect children with autism spectrum disorder (ASD). This is the first report of a child initially thought to have scurvy, then subsequently diagnosed with CNO as the presenting manifestation of Crohn's disease. Read More

Physiol Mol Biol Plants 2022 Apr 19;28(4):871-884. Epub 2022 Apr 19.

Plant Tissue Culture and Genetic Engineering Lab, National Agri- Food Biotechnology Institute (NABI), Department of Biotechnology, Ministry of Science and Technology (Government of India), Sector-81, Knowledge City, S.A.S. Nagar, Mohali, Punjab, 140306 India.

Ascorbic acid (AsA) also known as vitamin C is considered as an essential micronutrient in the diet of humans. The human body is unable to synthesize AsA, thus solely dependent on exogenous sources to accomplish the nutritional requirement. AsA plays a crucial role in different physiological aspects of human health like bone formation, iron absorption, maintenance and development of connective tissues, conversion of cholesterol to bile acid and production of serotonin. Read More

Ther Adv Chronic Dis 2022 29;13:20406223221078080. Epub 2022 Mar 29.

Department of Rheumatology, Singing River Health System, Ocean Springs, MS, USA.

Celiac disease (CD) is a multisystem disorder known to manifest in a multitude of ways to include diarrhea, anemia, and nutritional deficiencies. The malabsorptive state can present as certain classical conditions such as autoimmune gastritis and osteopenia/osteoporosis but scurvy is less recognized within the literature. In this case, we present a unique presentation of scurvy as a result of an undiagnosed CD. Read More

PLoS One 2022 6;17(4):e0265878. Epub 2022 Apr 6.

Biological Anthropology and Comparative Anatomy Research Unit, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

The British colony of South Australia, established in 1836, offered a fresh start to migrants hoping for a better life. A cohort of settlers buried in a section of St Mary's Anglican Church Cemetery (1847-1927) allocated for government funded burials was investigated to determine their health, with a focus on skeletal manifestations associated with metabolic deficiencies. Findings of St Mary's sample were compared with those published for contemporary skeletal samples from two British cemeteries, St Martin's, Birmingham, and St Peter's, Wolverhampton, to explore similarities and differences. Read More

J Trop Pediatr 2022 Apr;68(3)

Department of Paediatrics, KIMSHEALTH, Trivandrum, Kerala, India.

In modern society, scurvy is well known in its historical perspective rather than clinical relevance. Scurvy is classically thought to manifest with signs of 'bleeding painful gums' in the undernourished. Little is known regarding its ability to mimic a wide range of rheumatological, orthopaedic, neurological and haematological illnesses. Read More

Cureus 2022 Feb 26;14(2):e22622. Epub 2022 Feb 26.

Hematology and Medical Oncology, University of Arkansas for Medical Sciences, Little Rock, USA.

Scurvy is a nutritional disorder caused by vitamin C deficiency. It was a notorious disease in the ancient world, especially among the sailors, and is of rare occurrence in contemporary, developed countries due to increased access and advancement in nutrition services. Scurvy primarily affects the skin and soft tissue, presenting with a myriad of clinical manifestations ranging from musculoskeletal to bleeding-related complaints and even sudden death in later stages. Read More

Nutrients 2022 Feb 6;14(3). Epub 2022 Feb 6.

Gastroenterology Unit, Department of NEUROFARBA, Meyer Children's University Hospital, University of Florence, Viale Pieraccini 24, 50137 Florence, Italy.

Scurvy is a well-known clinical condition caused by vitamin C deficiency. Although considered a rare disease in high-income countries, it has been recently increasingly reported in children, especially in those with abnormal dietary habits, mental or physical disabilities. We performed an extensive review of the literature analyzing studies published in the last 20 years focusing on clinical features, differential diagnosis and diagnostic delay. Read More

JAAD Case Rep 2022 Apr 5;22:27-30. Epub 2022 Feb 5.

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.

BMJ Case Rep 2022 Mar 7;15(3). Epub 2022 Mar 7.

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA

A male in his 60s with a history of previously treated locally advanced head and neck cancer presented to the emergency department with atraumatic left knee pain and upper and lower extremity ecchymoses that had been present for 3 weeks. His initial laboratory results showed a normocytic anaemia, normal platelet count, slightly abnormal coagulation studies and normal inflammatory markers. Arthrocentesis of the left knee revealed haemarthrosis, and additional laboratory workup found an undetectable serum vitamin C (ascorbic acid) level consistent with scurvy. Read More

J Food Sci Technol 2022 Apr 17;59(4):1450-1459. Epub 2021 Jun 17.

Department of Industrial Chemistry, Arba Minch University, Arba Minch, Ethiopia.

Injera is one of the common foods which are highly consumed daily in all parts of Ethiopia. has been documented in Ayurveda for its medicinal uses in gout, syphilis, venereal disease, piles, osteoporosis, anorexia, diarrhoea, scurvy, menstrual disorders, otorrhoea and epistaxis. Despite the health benefit it offers, it is not used in East African cuisine. Read More

Front Nutr 2022 14;9:765499. Epub 2022 Feb 14.

Department of Pharmacy, Baotou Medical College, Baotou, China.

Koumiss is a traditional fermented dairy product with health and medicinal benefits. It is very popular in the Inner Mongolia Autonomous Region of China. The results of relevant studies have shown that koumiss can regulate the gastrointestinal environment, improve the absorption of nutrients, improve the body's intolerance to lactose, enhance the body's immunity, prevent scurvy and atherosclerosis, and aid in the treatment of tuberculosis. Read More

Br J Haematol 2022 Feb 6. Epub 2022 Feb 6.

Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany.

Am J Hematol 2022 May 9;97(5):E166-E167. Epub 2022 Feb 9.

Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.

Int J Womens Dermatol 2021 Dec 22;7(5Part A):647-652. Epub 2021 Sep 22.

Stanford University School of Medicine, Department of Dermatology, Palo Alto, California.

This review article focuses on the dermatologic manifestations of selected nutrient deficiencies, including protein-energy and micronutrient-related malnutrition. The various nutrient deficiencies presented may share common features. However, distinctive cutaneous signs may prompt clinicians to consider a nutritional cause and help distinguish a nutrient deficiency from other common dermatologic conditions. Read More

Radiol Case Rep 2022 Mar 31;17(3):802-807. Epub 2021 Dec 31.

Department of Radiology, Saitama Children's Medical Center, 1-2 Shintoshin Chuo-ku, 330-8777, Saitama, Japan.

Chronic recurrent multifocal osteomyelitis (CRMO) is aseptic and can be diagnosed by excluding other diseases, such as bacterial osteomyelitis, scurvy, metabolic disorders, and malignant diseases; therefore, bone biopsy is usually performed to confirm the diagnosis. To prevent misdiagnosis, the appropriate timing and location for biopsy should be determined from an active phase of inflammation. We presented 3 cases of CRMO involving the mandible: Case 1: A 2-year-old girl diagnosed with CRMO in the chronic phase. Read More

J Orthop Case Rep 2021 Aug;11(8):107-110

Department of Orthopaedic Surgery, MGM Medical College and Hospital, Navi Mumbai, Maharashtra, India.

Introduction: Scurvy is a rarely seen in pediatric patients nowadays, seen more in those with developmental delay, autism or those who are severely malnourished. Epiphyseal separations are known to occur in scurvy, but only a few such cases have been reported in children with cerebral palsy. The diagnosis is often misleading since other morbidities as trauma, malignancies, coagulopathies, septic arthritis, osteomyelitis, or rheumatologic disorders are often considered at first. Read More

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211067970

Crouse Irving Memorial Hospital, Syracuse, NY, USA.

Scurvy, caused by vitamin C deficiency, is a forgotten disease in the modern era of medicine. The prevalence of vitamin C deficiency in the United States is reported to be 7.1%. Read More

Intern Med J 2021 Dec;51(12):2146-2148

Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia.

Br J Nutr 2021 Dec 22:1-19. Epub 2021 Dec 22.

Vrije Universiteit Brussel, Faculty of Physical Education and Physiotherapy, Department of Movement and Sport Sciences, Pleinlaan 2, B-1050 Brussels, Belgium.

Greenlandic traditional nutrition was unique in the arctic environment. The aim of the present study was to reanalyze the Høygaard et al. data, focusing on two micronutrients object of discussion, i. Read More

Front Nutr 2021 1;8:762753. Epub 2021 Dec 1.

Center for Natural Products Technologies, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, United States.

Flavonoids are a vast group of metabolites that are essential for vascular plant physiology and, thus, occur ubiquitously in plant-based/-derived foods. The solitary designation of thousands of known flavonoids hides the fact that their metabolomes are structurally highly diverse, consist of disparate subgroups, yet undergo a certain degree of metabolic interconversion. Unsurprisingly, flavonoids have been an important theme in nutrition research. Read More

Orbit 2022 Feb 16;41(1):127-129. Epub 2021 Dec 16.

Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington, USA.

We present a case of spontaneous nontraumatic retrobulbar hemorrhage associated with anti-coagulation therapy and a new diagnosis of scurvy. A 68-year-old male on chronic anti-coagulation therapy presented with a retrobulbar hemorrhage requiring urgent canthotomy and cantholysis. Despite the absence of a supratherapeutic INR and normal clotting factors, the patient continued to have spontaneous hemorrhages within the orbit and elsewhere. Read More

JAAD Case Rep 2022 Jan 13;19:14-17. Epub 2021 Nov 13.

Dermatology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.

Arq Neuropsiquiatr 2021 12;79(12):1138-1144

Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Rio de Janeiro RJ, Brazil.

Background: The famous Brazilian Baroque sculptor named Antônio Francisco Lisboa, known as "Aleijadinho" (1738-1814), suffered from a deforming disease of the lower and upper limbs. The condition was characterized by atrophy, paresis and amputation. His face was also affected, with inflammation of the eyelids, deviation of the labial commissure, drooping of the chin and lower lip, giving him a sinister expression. Read More

BJR Open 2021 24;3(1):20210011. Epub 2021 Nov 24.

Department of Radiology, Shiga University of Medical Science, Shiga, Japan.

Vitamin deficiency is rare in modern industrialised countries; however, it still occurs in patients with specific backgrounds, such as those with extremely unbalanced diets, those with alcoholism and those who have undergone gastrointestinal surgery. Imaging examinations that demonstrate classic findings confirm the clinical diagnosis of vitamin deficiency and help monitor response to treatment. Because vitamin deficiencies are not prevalent, the diagnosis might not be straightforward. Read More

Clin Dermatol 2021 Jul-Aug;39(4):714-717. Epub 2021 May 19.

Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, United States. Electronic address:

Disorders with dermatologic features are intractable and rife in Shakespeare's world. For this reason, they occupy an unusual position in culture. "The plague" and "leprosy" are popular insults and epithets-indictments of not external pathogens but of moral failure. Read More

Clin Dermatol 2021 Sep-Oct;39(5):858-863. Epub 2021 May 24.

Private Practice, Pembroke Pines, Florida, USA. Electronic address:

Epidemics of nutritional deficiency disorders, caused by a lack of vitamins and minerals, were once very common and claimed many victims. Fortunately, advances in medicine have led to improved diets and a decline in the incidence of these disorders so that they are now seen clinically less often. Reminders of diseases such as scurvy, chlorosis, and pellagra can be found in artwork from the 19th century. Read More