2,736 results match your criteria Scurvy


NASPGHAN Position Paper: Plant-Based Milks.

J Pediatr Gastroenterol Nutr 2020 May 26. Epub 2020 May 26.

Associate Professor, Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Alberta, Alberta, Edmonton, Canada, Potential Conflict of Interest, Research funding from VectiveBio AG, for the NASPGHAN Committee on Nutrition.

Parents and caretakers are increasingly feeding infants and young children plant-based "milk" alternatives to cow milk. The US Food and Drug Administration currently defines "milk" and related milk products by the product source and the inherent nutrients provided by bovine milk. Substitution of a milk that does not provide a similar nutritional profile to cow milk can be deleterious to a child's nutritional status, growth and development. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002799DOI Listing

A bedside technique and historical aspects of the cutaneous findings in scurvy.

Int J Surg Case Rep 2020 May 21;71:126-127. Epub 2020 May 21.

University of Florida, Division of General Internal Medicine, 2000 SW Archer Rd., Gainesville, FL 32608, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ijscr.2020.04.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256203PMC

Nutritional deficiency presenting as acute pain, fatigue and bruising in a college health clinic.

J Am Coll Health 2020 May 20:1-3. Epub 2020 May 20.

Health Services, Brown University, Providence, Rhode Island, USA.

A previously healthy university student presents to Health Services with sudden onset of pain, fatigue, bruising, and a rapidly progressive anemia. There was not any previous significant health history. The case discussion will emphasize the critical overlap of physical and mental health assessments in identifying the cause and cure of a potentially life-threatening health crisis for a young adult student. Read More

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http://dx.doi.org/10.1080/07448481.2020.1767111DOI Listing

Mucocutaneous Manifestations of Scurvy.

N Engl J Med 2020 May;382(20):e56

University of Arkansas for Medical Sciences, Little Rock, AR

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http://dx.doi.org/10.1056/NEJMicm1911315DOI Listing

Surgeons, plague, and leadership: A historical mantle to carry forward.

Am J Surg 2020 May 5. Epub 2020 May 5.

Duke University Department of Surgery, DUMC 3704, Durham, NC, 27710, USA. Electronic address:

COVID-19 has sickened millions, killed hundreds of thousands, and disrupted daily life for citizens around the world. Utterly devastating, COVID-19 is but the most recent pandemic to sweep the globe. Throughout history, surgeons like Guy de Chauliac, James Lind, John Hunter, John Snow, and Walter Reed have led scientific campaigns to understand, prevent, and treat epidemics like the bubonic plague, scurvy, syphilis, cholera, and yellow fever. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.04.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198986PMC

Patients with Community Acquired Pneumonia Exhibit Depleted Vitamin C Status and Elevated Oxidative Stress.

Nutrients 2020 May 6;12(5). Epub 2020 May 6.

The Infection Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch 8011, New Zealand.

Pneumonia is a severe lower respiratory tract infection that is a common complication and a major cause of mortality of the vitamin C-deficiency disease scurvy. This suggests an important link between vitamin C status and lower respiratory tract infections. Due to the paucity of information on the vitamin C status of patients with pneumonia, we assessed the vitamin C status of 50 patients with community-acquired pneumonia and compared these with 50 healthy community controls. Read More

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http://dx.doi.org/10.3390/nu12051318DOI Listing

Comprehensive and quantitative stability study of ascorbic acid using capillary zone electrophoresis with ultraviolet detection and high-resolution tandem mass spectrometry.

J Sep Sci 2020 May 8. Epub 2020 May 8.

Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS), Faculté de sciences pharmaceutiques et biologiques, Université de Paris, Paris, France.

Ascorbic acid is a powerful antioxidant compound involved in many biological functions, and a chronic deficiency is at the origin of scurvy disease. A simple, rapid, and cost-effective capillary electrophoresis method was developed for the separation and simultaneous quantification of ascorbic acid and the major degradation products: dehydroascorbic acid, furfural, and furoic acid. Systematic optimization of the conditions was performed that enabled baseline separation of the compounds in less than 10 min. Read More

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http://dx.doi.org/10.1002/jssc.202000389DOI Listing

Concurrent beau lines, onychomadesis, and retronychia following scurvy.

Cutis 2020 03;105(3):146-147;149

Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.

Beau lines, onychomadesis, and retronychia are nail conditions with their own characteristic clinical findings. It has been hypothesized that these 3 disorders may share a common pathophysiologic mechanism of slowing and/or halting nail plate production at the nail matrix. We report the case of a 41-year-old woman who presented with concurrent Beau lines, onychomadesis, and retronychia 6 months following a diagnosis of scurvy. Read More

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The risk for scurvy in children with neurodevelopmental disorders.

Spec Care Dentist 2020 May 24;40(3):251-259. Epub 2020 Apr 24.

Department of Pediatric Dentistry, The University of Texas Health Science Center at Houston, School of Dentistry, Houston, Texas, USA.

Background: Scurvy, the disease resulting from vitamin C deficiency, is perceived as being rare and occurring predominantly in the past. However, scurvy continues to exist and may be encountered in children with medical/developmental conditions and/or restricted diet. Diagnosis can be challenging given the perceived rarity of the condition and nonspecific symptoms, including gingival disease. Read More

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http://dx.doi.org/10.1111/scd.12459DOI Listing

Old Era Continues in Modern World: A Case Report of Scurvy Induced Myopathy in Patient with Chronic Alcoholism.

Case Rep Med 2020 9;2020:4798941. Epub 2020 Apr 9.

Florida International University, Miami, FL, USA.

We report a case of myopathy in a chronic alcoholic patient with scurvy who presented with generalized weakness, myalgias, and arthralgia. Our case raises awareness regarding rare interaction between vitamin C deficiency and myopathy which is seen more commonly in patients with history of chronic alcoholism and low socioeconomic status. Early treatment with vitamin C replacement is helpful in treatment of the disease and its complications. Read More

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http://dx.doi.org/10.1155/2020/4798941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171605PMC

Interaction between aspirin and vitamin C with human serum albumin as binary and ternary systems.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Aug 13;236:118356. Epub 2020 Apr 13.

School of Chemistry, Nanchang University, Nanchang 330031, China.

Foods generally contain special ingredients which easily to interact with drugs human intaking, thus affecting drug efficacy and excretion, and even cause adverse reactions. Vitamin C (Vit. C) is abundant in fresh fruits and vegetables. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118356DOI Listing
August 2020
2.353 Impact Factor

Is it leukemia, doctor? No, it's scurvy induced by an ARFID!

Eur J Clin Nutr 2020 Apr 20. Epub 2020 Apr 20.

Institut d'Hématologie et Oncologie Pédiatrique, Lyon, France.

We report the case of a 14-year-old boy with a completely normal medical and social background (good student and handball practice). A dentist monthly followed this patient for an orthodontic treatment. Facing with symptoms associating purpura, pancytopenia, and limbs pain, the first diagnosis that came to mind to emergency pediatricians was acute leukemia and the patient was addressed to a hematology department. Read More

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http://dx.doi.org/10.1038/s41430-020-0640-5DOI Listing

Scurvy: An Unexpected Nutritional Complication in an Adolescent Female With Anorexia Nervosa.

J Adolesc Health 2020 Apr 11. Epub 2020 Apr 11.

Division of Adolescent Medicine, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada; Research Institute, Hospital for Sick Children, Toronto, Canada. Electronic address:

Vitamin C deficiency results in the clinical presentation of scurvy, a disease that is rare among the adolescent population. Individuals with unusual dietary habits, mental illness, or physical disability are more prone to develop scurvy. We present a case report of a previously healthy 16-year-old female presented to the hospital with a 12-month history of anorexia nervosa, restrictive subtype. Read More

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http://dx.doi.org/10.1016/j.jadohealth.2020.02.022DOI Listing

Cook's Endeavour, ship of discovery or ship of distemper: an assessment after 250 years.

Authors:
Bruce H Short

Intern Med J 2020 Apr;50(4):495-498

Sydney, New South Wales, Australia.

The 250-year anniversary of Cook's landfall at Botany Bay on 28 April 1770, approximately half way through a global circumnavigation, was an extraordinary maritime undertaking. An enterprise of astronomy, cartography, cultural-botanical documentation and revelation achieved without a death from infectious disease and only 10 mild cases of scurvy in a ship's company of 95 men. The subsequent homeward journey was far less endurable, marked by shipwreck, unforeseen prolonged delays and fatal epidemics of flux and malaria. Read More

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http://dx.doi.org/10.1111/imj.14795DOI Listing

Infantile scurvy: Still a relevant differential diagnosis in Western medicine.

Nutrition 2020 Jan 30;75-76:110726. Epub 2020 Jan 30.

University Hospital Bonn, Department of Orthopedics and traumatology, Bonn, Germany.

Objective: Infantile scurvy or Moller-Barlow's disease appears to be of no further importance in Western countries; however, this is a careless assumption. In severely disabled children especially, this malady manifests itself in a broad range of symptoms such as delayed or suppressed bone healing, minor traumatization leading to bruises or fractures, and epiphysiolysis.

Methods: The aim of this article was to present the required daily uptake of vitamin C and the biochemical pathways in the human body leading to the typical symptoms of scurvy. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110726DOI Listing
January 2020

Vitamin C and Its Role in Periodontal Diseases - The Past and the Present: A Narrative Review.

Oral Health Prev Dent 2020 ;18(2):115-124

In humans, ascorbic acid, better known as vitamin C, is a true vitamin because humans lack the ability to synthesise it. Vitamin C exhibits a number of enzymatic and non-enzymatic effects but all are accounted for by the ability of vitamin C to donate electrons and therefore acts as a reducing agent. It has a wide range of functions. Read More

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http://dx.doi.org/10.3290/j.ohpd.a44306DOI Listing

Scurvy: Forgotten diagnosis, but still exist.

Int J Surg Case Rep 2020 7;68:263-266. Epub 2020 Mar 7.

Department of Orthopaedic - Traumatology, Faculty of Medicine Universitas, Indonesia.

Introduction: Scurvy is a rare condition in pediatric patients, resulted from a vitamin C deficiency. Musculoskeletal symptoms occur in 80% of patient. The rarity and the polymorphisms of the clinical signs and symptoms often make scurvy an unknown or forgotten diagnosis. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082595PMC

Revisiting the pathobiology of scurvy: a review of the literature in the context of a challenging case.

Int J Dermatol 2020 Mar 10. Epub 2020 Mar 10.

Departments of Dermatology and Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA.

Scurvy is a nutritional disorder resulting from vitamin C deficiency. Although rare in developing countries, scurvy continues to develop in settings of limited dietary intake such as post-gastrointestinal surgery and restrictive dietary habits. The disease primarily affects the skin and soft tissue. Read More

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http://dx.doi.org/10.1111/ijd.14832DOI Listing

Child with prolonged leg pain and bruising.

Arch Dis Child Educ Pract Ed 2020 Mar 8. Epub 2020 Mar 8.

Department of Paediatrics, Lister Hospital, Stevenage, UK.

A 12-year-old boy was admitted to the paediatric ward with a 4-month history of worsening pain and bruising to his legs, which had resulted in a progressive reduction in his mobility. He initially had had difficulty weight bearing, which had then progressed further making him wheelchair bound. On examination, there was extensive bruising (figure 1) to his oedematous legs, worse on his right leg compared with his left. Read More

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http://dx.doi.org/10.1136/archdischild-2019-318124DOI Listing

James Cook's first Pacific voyage: alleged scurvy-freedom unmasked.

Authors:
Bruce H Short

Intern Med J 2020 Mar;50(3):378-380

Medical Historian, Sydney, New South Wales, Australia.

The east coast of New Holland was discovered 250 years ago during a voyage of covert strategic exploration of the Pacific Ocean regions by Lieutenant James Cook acting under instructions of the Royal Navy espionage chief, Philip Stephens, Secretary of the Admiralty. In addition to the study of the transit of Venus, the well resourced mission included some clandestine mapmaking during August 1768 to July 1771. Tasked by the Royal Society of London to investigate the anti-scorbutic effects of a variety of foods and herbs, Cook's post-operational debrief to the Admiralty included the inaccurate supposition that HM Bark Endeavour's cruise was scurvy-free. Read More

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http://dx.doi.org/10.1111/imj.14761DOI Listing

Now you C me: a case of scurvy presenting as depression and anaemia.

BMJ Case Rep 2020 Mar 4;13(3). Epub 2020 Mar 4.

Department of General Medicine, Monash Health, Clayton, Victoria, Australia.

A 66-year-old Caucasian woman was admitted with deteriorating mental health in the setting of background history of schizophrenia and depression. Her husband reported that she had increasing negative thoughts and decreased motivation regarding her self-care over a few weeks with no obvious stressors. Initial laboratory tests were unremarkable except for isolated normocytic anaemia. Read More

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http://dx.doi.org/10.1136/bcr-2019-233645DOI Listing

Reversible Pulmonary Hypertension Secondary to Scurvy in a Patient with a Psychiatric Disorder: a Case Report and Literature Review.

Eur J Case Rep Intern Med 2020 10;7(2):001404. Epub 2020 Jan 10.

Internal Medicine Service, Federal University of Pernambuco, Recife, Brazil.

Pulmonary hypertension (PH) can be related to several diseases, such as connective tissue disorders and pulmonary embolism, or to drugs; it may also be idiopathic. Few cases have been reported demonstrating an association between ascorbic acid deficiency and reversible PH. We report the case of a patient who arrived at the emergency department with dyspnoea, tachycardia and lower limb perifollicular haemorrhage. Read More

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http://dx.doi.org/10.12890/2020_001404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050966PMC
January 2020

Scurvy: A New Old Cause of Skeletal Pain in Young Children.

Front Pediatr 2020 31;8. Epub 2020 Jan 31.

General Pediatrics Department, Necker Hospital, Paris, France.

We report 3 cases of scurvy in children that occurred during a short period (2018) in a general pediatrics unit of a tertiary hospital for children in Paris. All children were around 3 years of age and were admitted for skeletal pain and altered general state, which mimicked infectious or malignant diseases. Their selective diet was not the prominent issue. Read More

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http://dx.doi.org/10.3389/fped.2020.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006051PMC
January 2020

Scurvy as a Sequela of Avoidant-Restrictive Food Intake Disorder in Autism: A Systematic Review.

J Dev Behav Pediatr 2020 Feb 10. Epub 2020 Feb 10.

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.

Objective: To document the clinical presentation of scurvy in children with autism spectrum disorder (ASD) and summarize the contemporary approaches to assessment and management in this population. Scurvy is a disease caused by vitamin C deficiency most often detected in populations at high risk for nutrition insufficiency (e.g. Read More

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http://dx.doi.org/10.1097/DBP.0000000000000782DOI Listing
February 2020

Synergistic effect of ascorbic acid and taurine in the treatment of a spinal cord injury-induced model in rats.

3 Biotech 2020 Feb 16;10(2):50. Epub 2020 Jan 16.

Department of Spine Surgery, Tianjin Hospital, Tianjin, 300211 China.

Spinal cord injury (SCI) results in severe damage, which causes functional alterations together with loss of autonomic functions, sensations, and muscle functioning. This injury leads to apoptosis of neurons and oligodendrocytes, which further leads to dysfunction of the spinal cord due to axonal degeneration and demyelination. Taurine is non-proteogenic and an essential amino acid, which plays a major role in the growth and development of brain cells. Read More

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http://dx.doi.org/10.1007/s13205-019-2032-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965563PMC
February 2020

Modern-day scurvy.

CMAJ 2020 Jan;192(4):E96

Department of Medicine (Colacci, Gold, Shah), University of Toronto; Divisions of Infectious Diseases (Gold) and General Internal Medicine (Gold, Shah), University Health Network, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.190934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989015PMC
January 2020

Scurvy may occur even in children with no underlying risk factors: a case report.

J Med Case Rep 2020 Jan 24;14(1):18. Epub 2020 Jan 24.

Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98124, Messina, Italy.

Background: Since ancient times, scurvy has been considered one of the most fearsome nutritional deficiency diseases. In modern developed countries, this condition has become very rare and is only occasionally encountered, especially in the pediatric population. Underlying medical conditions, such as neuropsychiatric disorders, anorexia nervosa, celiac disease, Crohn disease, hemodialysis, and severe allergies to food products may enhance the risk of developing scurvy. Read More

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http://dx.doi.org/10.1186/s13256-020-2341-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979388PMC
January 2020

A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection.

Nutrients 2020 Jan 16;12(1). Epub 2020 Jan 16.

Bayer Consumer Care AG, 4002 Basel, Switzerland.

Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including vitamins A, D, C, E, B6, and B12, folate, zinc, iron, copper, and selenium, which play vital, often synergistic roles at every stage of the immune response. Adequate amounts are essential to ensure the proper function of physical barriers and immune cells; however, daily micronutrient intakes necessary to support immune function may be higher than current recommended dietary allowances. Read More

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http://dx.doi.org/10.3390/nu12010236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019735PMC
January 2020

Clinical Profile of Scurvy in Hamilton Since 2009: a Cohort Study.

J Gen Intern Med 2020 Jan 15. Epub 2020 Jan 15.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1007/s11606-020-05636-1DOI Listing
January 2020

Chapter 6: Vitamins and Oral Health.

Monogr Oral Sci 2020 7;28:59-67. Epub 2019 Nov 7.

Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Indiana, USA.

Vitamins are essential organic compounds that catalyze metabolic reactions. They also function as electron donors, antioxidants or transcription effectors. They can be extracted from food and supplements, or in some cases, synthesized by our body or gut microbiome. Read More

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http://dx.doi.org/10.1159/000455372DOI Listing
January 2020

Impact of Nutrition on Pulmonary Arterial Hypertension.

Nutrients 2020 Jan 7;12(1). Epub 2020 Jan 7.

Department of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Pulmonary arterial hypertension (PAH) is characterized by sustained vasoconstriction, vascular remodeling, inflammation, and in situ thrombosis. Although there have been important advances in the knowledge of the pathophysiology of PAH, it remains a debilitating, limiting, and rapidly progressive disease. Vitamin D and iron deficiency are worldwide health problems of pandemic proportions. Read More

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http://dx.doi.org/10.3390/nu12010169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019983PMC
January 2020

[Exertional dyspnea, myalgia, petechiae of the lower extremities and pronounced gingivitis in a 64-year-old female patient].

Internist (Berl) 2020 Feb;61(2):213-216

Schön Klinik Hamburg Eilbek, Dehnhaide 120, 22081, Hamburg, Deutschland.

A female patient presented with exertional dyspnea, myalgia, a petechial rash of the lower extremities and pronounced gingivitis. The biochemical test results showed the presence of anemia. The patient had a known eating disorder and on questioning about eating habits admitted that she did not eat any fruit or vegetables. Read More

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http://dx.doi.org/10.1007/s00108-019-00712-zDOI Listing
February 2020

Comment on Charlier et al., 2019: "The Mandible of Saint-Louis (1270 AD): Retrospective diagnosis and circumstances of death".

J Stomatol Oral Maxillofac Surg 2020 Apr 2;121(2):192-194. Epub 2020 Jan 2.

Department of Anatomy, University of Otago, 270 Great King Street, Dunedin, 9016 Otago, New Zealand.

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http://dx.doi.org/10.1016/j.jormas.2019.12.013DOI Listing

Further anthropological and pathological arguments related to St Louis' scurvy and infection signs on the Notre-Dame mandible (Paris, France).

J Stomatol Oral Maxillofac Surg 2020 Apr 2;121(2):194-197. Epub 2020 Jan 2.

Legal Medicine Section, Department of Public Health and Pediatric Sciences, University of Turin, Italy; Warwick Medical School, Biomedical Sciences, The University of Warwick, Coventry, United Kingdom; Faculté de Médecine de Marseille, UMR 7268, Laboratore d'Anthropologie bio-culturelle, Droit, Ethique & Santé (Adés), France.

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http://dx.doi.org/10.1016/j.jormas.2019.12.011DOI Listing

No longer a historical ailment: two cases of childhood scurvy with recommendations for bone health providers.

Osteoporos Int 2020 May 4;31(5):1001-1005. Epub 2020 Jan 4.

Golisano Children's Hospital, University of Rochester Medical Center, Rochester, NY, USA.

Purpose: Scurvy, due to vitamin C deficiency, is commonly referenced as a "forgotten" or "historical" disease. A growing number of case reports challenge this notion. Bone health providers are often consulted early in the presentation of scurvy to evaluate musculoskeletal complaints resulting from impaired collagen production and disrupted endochondral bone formation. Read More

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http://dx.doi.org/10.1007/s00198-019-05264-4DOI Listing

[Bloody tears: About a case and a review of the literature].

Rev Med Interne 2020 May 24;41(5):339-342. Epub 2019 Dec 24.

Vascular hemostasis unit, Normandie Univ, UNIROUEN, Inserm U1096, Rouen university hospital, 76000 Rouen, France.

Introduction: Hemolacria is a rare hemorrhagic syndrome characterized by bloody tears. The most common etiologies are inflammation, infection or laceration. However, other rarer diseases may also cause this clinical manifestation. Read More

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http://dx.doi.org/10.1016/j.revmed.2019.12.007DOI Listing

Scurvy: A Rare Cause of Bone Marrow Edema.

J Clin Rheumatol 2019 Dec 21. Epub 2019 Dec 21.

From the Department of Rheumatology, Frimley Park Hospital, Frimley, Camberley, United Kingdom.

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http://dx.doi.org/10.1097/RHU.0000000000001237DOI Listing
December 2019

Ascorbic Acid Route to the Endoplasmic Reticulum: Function and Role in Disease.

Antioxid Redox Signal 2020 Jan 22. Epub 2020 Jan 22.

Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Milan, Italy.

Humans cannot synthesize ascorbic acid (AscH) (vitamin C), so deficiencies in dietary AscH cause the life-threatening disease of scurvy and many other diseases. After oral ingestion, plasma AscH concentrations are strictly controlled by transporters, which are required for entry into the cell and into intracellular organelles. Besides its general antioxidant function, AscH is a cofactor for endoplasmic reticulum (ER)-localized collagen hydroxylases. Read More

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http://dx.doi.org/10.1089/ars.2019.7912DOI Listing
January 2020

Hematopoietic findings in a patient with scurvy.

Blood 2019 12;134(25):2330

Children's Hospital of Philadelphia.

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http://dx.doi.org/10.1182/blood.2019002677DOI Listing
December 2019

Eighteenth Century Complications With 21st Century General Anesthesia: A Case Report of Scurvy.

A A Pract 2020 Jan;14(1):15-17

From the Department of Anesthesia, Cook Children's Medical Center, Fort Worth, Texas.

Autism spectrum disorder (ASD) may be associated with self-imposed dietary restrictions causing nutritional deficiencies, and the anesthesiologist must be aware of their potential clinical implications. Because humans are unable to produce ascorbic acid through endogenous metabolic pathways and children with ASD may avoid vitamin C-containing foods, vitamin C deficiency, or scurvy, may develop in patients scheduled for general anesthesia. Vitamin C deficiency may cause dysfunction in autonomic nervous system processes or pulmonary hypertension resulting in unexpected hemodynamic lability. Read More

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http://dx.doi.org/10.1213/XAA.0000000000001132DOI Listing
January 2020

Scurvy Masquerading as Juvenile Idiopathic Arthritis or Vasculitis with Elevated Inflammatory Markers: A Case Series.

J Pediatr 2020 Mar 13;218:234-237.e2. Epub 2019 Dec 13.

Department of Pediatric Rheumatology, Seattle Children's Hospital and Research Center, Seattle, WA. Electronic address:

Ten patients with scurvy were evaluated by rheumatology; we review their clinical, laboratory, and dietary presentations. Eight patients had developmental delay or autism. All had elevated inflammatory markers. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.10.059DOI Listing

Scurvy: An Unrecognized and Emerging Public Health Issue in Developed Economies.

Mayo Clin Proc 2019 12;94(12):2594-2597

Department of Medicine, Faculty of Medicine and Health, The University of Sydney, Nepean Hospital, Kingswood, Australia.

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http://dx.doi.org/10.1016/j.mayocp.2019.10.005DOI Listing
December 2019

[Cutaneous manifestations of nutritional deficiencies].

Rev Med Suisse 2019 Nov;15(672):2125-2130

Service de médecine interne, Département de médecine, CHUV, 1011 Lausanne.

In elderly or chronically ill patients, nutritional deficiencies are common and the presence of related skin lesions is not unusual. Recognition of such cutaneous involvement is important regarding the diagnosis essentially based on clinical elements. By using some clinical case reports, we will describe several pathologies related to nutritional deficiencies like scurvy, pellagra and acquired acrodermatitis enteropathica. Read More

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November 2019

The association between vitamin deficiency and otolaryngologic diseases: A therapeutic target.

Med Hypotheses 2020 Feb 23;135:109448. Epub 2019 Oct 23.

The Third Hospital of Wuhan City, Wuhan, China. Electronic address:

Vitamins are indispensable nutrients for metabolism. Adequate vitamin intake plays vital role in physiological processes including embryonic development, cellular and immunity proliferation and differentiation, DNA synthesis and oxidative response. In contrast, insufficient vitamin levels usually lead to a large number of clinical manifestations including xerophthalmia, nyctalopia, hyperpigmentation, vitiligo, jaundice, megaloblastic anemia, glossitis, scurvy, stroke, cancer, coronary heart disease, Alzheimer's disease, multiple sclerosis and Parkinson's disease. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.109448DOI Listing
February 2020

Images of the month 1: 'The scurvy' - diagnosis by gestalt.

Clin Med (Lond) 2019 Nov;19(6):526-527

Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK

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http://dx.doi.org/10.7861/clinmed.2019-0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899258PMC
November 2019

Scurvy: A Rare Cause of Anemia.

Cureus 2019 Sep 18;11(9):e5694. Epub 2019 Sep 18.

Hematology and Oncology, Cleveland Clinic - Fairview Hospital, Cleveland, USA.

Scurvy is a rather uncommon disease today, and its symptoms can certainly be exhibited with vitamin C deficiency. Dangerously low levels of the vitamin can cause serious health complications and have been proven to be fatal. We present the case of a 42-year-old female with multiple primary diagnoses: easy bruising and Raynaud's syndrome without gangrene. Read More

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http://dx.doi.org/10.7759/cureus.5694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823021PMC
September 2019

Increases in Acute Phase Reactants in a Patient with Scurvy Despite No Inflammation: Review of Literature.

Cureus 2019 Sep 9;11(9):e5608. Epub 2019 Sep 9.

Pediatrics, Nihon Uniiversity School of Medicine, Tokyo, JPN.

So far, little attention has been paid to the increase in acute phase reactants (APRs) in patients with scurvy. We report that elevated levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and serum amyloid A were shown in a pediatric patient with scurvy despite the absence of inflammation. These peculiar findings are important to discriminate scurvy from other rheumatic diseases. Read More

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http://dx.doi.org/10.7759/cureus.5608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822559PMC
September 2019

Immunomodulatory and Antimicrobial Effects of Vitamin C.

Eur J Microbiol Immunol (Bp) 2019 Oct 16;9(3):73-79. Epub 2019 Aug 16.

Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Humans have lost their vitamin C-synthesizing capacities during evolution. Therefore, the uptake of this essential compound from external sources is mandatory in order to prevent vitamin C-deficient conditions resulting in severe morbidities such as scurvy. The potent antioxidant, immunomodulatory, and antiinfectious effects of vitamin C are known since the 1930s. Read More

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http://dx.doi.org/10.1556/1886.2019.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798581PMC
October 2019