3,993 results match your criteria Scrub Typhus


Bacterial microbiome of the chigger mite Leptotrombidium imphalum varies by life stage and infection with the scrub typhus pathogen Orientia tsutsugamushi.

PLoS One 2018 6;13(12):e0208327. Epub 2018 Dec 6.

Department of Entomology and Plant Pathology, North Carolina State University, Raleigh, North Carolina, United States of America.

Scrub typhus is a mites-borne rickettsiosis caused by the obligate intracellular Gram-negative bacterium Orientia tsutsugamushi. The disease is potentially life threatening and is prevalent in tropical Asia, islands of the western Pacific Ocean and northern Australia where an estimated one million cases occur annually. Orientia tsutsugamushi is transmitted by the bite of larval mites in the genus Leptotrombidium. Read More

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December 2018

Short-distance barriers affect genetic variability of L. in the Yucatan Peninsula.

Ecol Evol 2018 Nov 19;8(22):11083-11099. Epub 2018 Oct 19.

Centro de Investigación Científica de Yucatán (CICY) Mérida México.

The environmental variability at local scale results in different physiognomic types of mangrove forest. However, this variability has never been considered in studies of mangrove genetic variability. This study analyzed the genetic and morphological variability and structure of at regional and local scales in the Yucatan Peninsula. Read More

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November 2018

Geometric morphometrics of the scutum for differentiation of trombiculid mites within the genus Walchia (Acariformes: Prostigmata: Trombiculidae), a probable vector of scrub typhus.

Ticks Tick Borne Dis 2018 Nov 16. Epub 2018 Nov 16.

Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Electronic address:

The vectors of scrub typhus are the larval stage of trombiculid mites, termed "chiggers". These vectors are very small - the larvae are approximately 0.2 mm in size - and therefore their morphological identification is difficult. Read More

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November 2018

Exploration of microplastics from personal care and cosmetic products and its estimated emissions to marine environment: An evidence from Malaysia.

Mar Pollut Bull 2018 Nov 11;136:135-140. Epub 2018 Sep 11.

Faculty of Science and Engineering, SOKA University, Tokyo, Japan.

This study aims understand microplastics from personal care and cosmetic products in Malaysia via quantification and characterization of microplastics together with emission estimation to marine environment. A total of 214 respondents from all over Malaysia were surveyed with identification of top ten personal care and cosmetic products usage. Particles found in facial cleaner/scrub and toothpaste were colored and colorless with majority of granular shapes. Read More

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November 2018

Scrub typhus and depression: a nationwide cohort analysis.

J Transl Med 2018 Dec 3;16(1):333. Epub 2018 Dec 3.

Department of Medical Research, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan.

Background: Studies on the relationship between depression and scrub typhus are limited. We conducted a retrospective cohort study to investigate whether scrub typhus is a risk factor for depression.

Methods: Using Taiwan's National Health Insurance Research Database, this study investigated the incidence of depression, and its risk factors, in patients diagnosed with scrub typhus between 2000 and 2010. Read More

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December 2018

Antiseptic efficacies of waterless hand rub, chlorhexidine scrub, and povidone-iodine scrub in surgical settings: a meta-analysis of randomized controlled trials.

J Hosp Infect 2018 Nov 27. Epub 2018 Nov 27.

Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Division of General Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background: Presurgical hand washing is crucial for preventing surgical site infections (SSIs). Chlorhexidine gluconate (CHG) and povidone-iodine (PI) products have been conventionally used as hand scrubs for presurgical hand preparation. However, waterless hand rub (WHR) products have been developed for operating room staff. Read More

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November 2018

Radiation Exposure to the Surgeon, Surgical Assistant and Scrub Nurse during Closed Intramedullary Nailing of Long Bones -Does It Vary Depending on the Experience of the Surgeon?

J Orthop Trauma 2018 Oct 8. Epub 2018 Oct 8.

Department of Orthopaedic surgery, Ganga Hospital, 313, Mettupalayam road, Coimbatore, India.

Objectives: To assess radiation exposure (RE) to the surgical team and fluoroscopy time (FT) during closed nailing of long bone fractures performed under fluoroscopic guidance with regard to surgeons experience.

Design: Prospective observational study SETTING:: Level-1 Trauma Centre PARTICIPANTS:: Surgical team, comprising surgeon, surgical assistant and scrub nurse, for closed nailings done in 202 consecutive closed tibial and femoral diaphyseal fractures.

Intervention: Dosimeter provided to each member of surgical team; Surgeon experience-level (Trainee, Senior registrar, Consultant) MAIN OUTCOME MEASUREMENTS:: RE (microsieverts) to the surgical team and FT (minutes) were recorded from the dosimeter and fluoroscopic unit respectively and correlated with surgeons experience. Read More

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October 2018

Ultrastructural visualization of Orientia tsutsugamushi in biopsied eschars and monocytes from scrub typhus patients in South Korea.

Sci Rep 2018 Nov 26;8(1):17373. Epub 2018 Nov 26.

Drug & Disease Target Team, Korea Basic Science Institute, Cheongju, 28119, South Korea.

Scrub typhus, which is caused by Orientia tsutsugamushi, is a public health problem in the Asian-Pacific region and is the third most frequently reported infectious disease in South Korea. While ultrastructural studies have been performed on O. tsutsugamushi in murine fibroblasts, its variable locations in patients have hampered similar studies in humans. Read More

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November 2018
1 Read

Socio-demographic and Clinico-Epidemiological Study of Scrub Typhus in Two Tertiary Care Hospitals of Kolkata.

J Assoc Physicians India 2018 May;66(5):22-25

Department of Medicine, VIMS, Kolkata, West Bengal.

Background And Aims : Scrub typhus is the commonest of the rickettsial diseases in India and is difficult to diagnose. Untreated cases have fatality rates of 30-45%. Eschar is present in 7-97% cases. Read More

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May 2018
3 Reads

Factors for Severe Outcome in Scrub Typhus: A Hospital Based Study in Sub Himalayan Region.

J Assoc Physicians India 2018 May;66(5):36-38

Professor, Department of Microbiology, IGMC, Shimla, Himachal Pradesh.

Background: Scrub typhus is a re-emerging zoonotic rickettsial infection. Mortality is approximately 15% in some areas due to missed or delayed diagnosis. There had been only few studies on the markers for the severity of the disease, so this study has been planned to provide the knowledge regarding various aspects of scrub typhus in adult age group to detect early signs of severity . Read More

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May 2018
5 Reads

Risk Factors for Acquiring Scrub Typhus among Children in Deoria and Gorakhpur Districts, Uttar Pradesh, India, 2017.

Emerg Infect Dis 2018 Dec;24(12):2364-2367

Scrub typhus is associated with outbreaks of acute encephalitis syndrome in Uttar Pradesh, India. A case-control study indicated that children residing, playing, or visiting fields; living with firewood stored indoors; handling cattle fodder; and practicing open defecation were at increased risk for scrub typhus. Communication messages should focus on changing these behaviors. Read More

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December 2018
3 Reads

Bayesian zero-inflated spatio-temporal modelling of scrub typhus data in Korea, 2010-2014.

Geospat Health 2018 11 9;13(2). Epub 2018 Nov 9.

Department of Applied Statistics, Hanyang University, Seoul.

Scrub typhus, a bacterial, febrile disease commonly occurring in the autumn, can easily be cured if diagnosed early. However, it can develop serious complications and even lead to death. For this reason, it is an important issue to find the risk factors and thus be able to prevent outbreaks. Read More

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November 2018
5 Reads

Ocular manifestations of in South India.

Indian J Ophthalmol 2018 Dec;66(12):1840-1844

Resident, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Salem, Tamil Nadu, India.

Purpose: Among the major groups of rickettsiosis, the commonly reported diseases in India are: (a) Typhus group induced-scrub typhus, murine flea-borne typhus; (b) Spotted fever group induced-Indian tick typhus; and (c) Q fever. Though many scrub typhus outbreaks have been reported from India, only one outbreak of spotted fever-serologically proven Indian tick typhus (Rickettsia conorii)-has been reported. We report for the first time ocular manifestations of serologically proven R. Read More

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December 2018
3 Reads

Vaginal cleansing prior to caesarian section: To do or not to do?: A randomized trial.

J Gynecol Obstet Hum Reprod 2018 Nov 14. Epub 2018 Nov 14.

Faculty of Medicine, Taif University, Saudi Arabia. Electronic address:

Purpose: To evaluate the efficacy of preoperative vaginal cleansing using povidone-iodine solution 10% on rates of post cesarean section (CS) infectious morbidities (endometritis, febrile morbidity and wound infection).

Methods: This prospective randomized trial was conducted among 226 pregnant women scheduled for term elective CS. Patients were equally divided into two groups by simple randomization method. Read More

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November 2018
1 Read

Genomes of trombidid mites reveal novel predicted allergens and laterally transferred genes associated with secondary metabolism.

Gigascience 2018 Dec 1;7(12). Epub 2018 Dec 1.

Institute of Infection & Global Health, University of Liverpool, L3 5RF, United Kingdom.

Background: Trombidid mites have a unique life cycle in which only the larval stage is ectoparasitic. In the superfamily Trombiculoidea ("chiggers"), the larvae feed preferentially on vertebrates, including humans. Species in the genus Leptotrombidium are vectors of a potentially fatal bacterial infection, scrub typhus, that affects 1 million people annually. Read More

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December 2018
3 Reads

Implant Prophylaxis: The Next Best Practice Toward Asepsis in Spine Surgery.

Global Spine J 2018 Oct 24;8(7):761-765. Epub 2018 Apr 24.

USC Spine Center, Los Angeles, CA, USA.

Study Design: A literature review.

Objectives: An evaluation of the contaminants prevalent on implants used for surgery and the aseptic methods being employed against them.

Methods: PubMed was searched for articles published between 2000 and 2017 for studies evaluating the contaminants present on spine implants, and associated pre- and intraoperative implant processing and handling methodology suggested to avoid them. Read More

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October 2018
5 Reads

Resolving tradeoffs among crypsis, escape behavior, and microhabitat use in sexually dichromatic species.

Oecologia 2018 Nov 14. Epub 2018 Nov 14.

Department of Biology, Georgia Southern University, PO Box 8042-1, Statesboro, GA, 30460, USA.

Variation in color pattern between populations of cryptic animals is common and typically attributed to selection pressures from visual predators combined with variation in substrate composition. However, little is known about how cryptic color pattern relates to varied rates of predation, and few studies simultaneously analyze patterns of escape behavior and microhabitat use along with variation in color pattern, even though these traits evolve in tandem. Here, we use a combination of calibrated photographs and spectrometry to examine the influence of spatial heterogeneity in rates of predation on dorsal brightness in the Florida scrub lizard (Sceloporus woodi), a cryptic and sexually dimorphic species. Read More

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November 2018

Use of eschar for the molecular diagnosis and genotypic characterisation of causing scrub typhus.

Indian J Med Microbiol 2018 Jul-Sep;36(3):422-425

Department of Paediatric Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Scrub typhus caused by Orientia tsutsugamushi presents as an acute febrile illness with a varied presentation from mild illness to fatal disease in the absence of appropriate antibiotic treatment. Performing polymerase chain reaction (PCR) on eschar sample acts a rapid diagnostic tool in the early stage of scrub typhus when blood is negative. A total of eight patients from whom both whole blood and eschar samples were collected and tested by nested PCR targeting 56 kDa trichostatin A (TSA) gene to detect O. Read More

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November 2018
4 Reads

Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan.

Korean J Parasitol 2018 Oct 31;56(5):521-525. Epub 2018 Oct 31.

International Development Group, School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Rodents are well-known reservoirs and vectors of many emerging and re-emerging infectious diseases, but little is known about their role in zoonotic disease transmission in Bhutan. In this study, a cross-sectional investigation of zoonotic disease pathogens in rodents was performed in Chukha district, Bhutan, where a high incidence of scrub typhus and cases of acute undifferentiated febrile illness had been reported in people during the preceding 4-6 months. Twelve rodents were trapped alive using wire-mesh traps. Read More

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October 2018
4 Reads

How can the presence of a surgical care practitioner improve training for staff who are learning how to scrub for robotics cases in a urology theatre?

Authors:
Prue Barry

J Perioper Pract 2018 Nov 12:1750458918803523. Epub 2018 Nov 12.

Churchill Theatre Department, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Aim: This study examines how a surgical care practitioner can contribute to the learning needs of junior scrub staff learning to scrub for urological robotics cases. Key themes include education, technical training, non-technical skills, patient safety and the specialist practitioner as educator.

Methods: Data collection was via an online survey, distributed by a gatekeeper to 13 participants. Read More

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November 2018

Cost-effectiveness Analysis and Safety of Erythromycin 4%Gel and 4% Chlorhexidine Scrub for Pitted Keratolysis Treatment.

J Dermatolog Treat 2018 Nov 12:1-11. Epub 2018 Nov 12.

a Department of Dermatology, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.

Background: Studies of Pitted keratolysis (PK) treatment are limited.

Objectives: To study cost-effectiveness and to compare the safety of 4% chlorhexidine scrub with 4% erythromycin gel, for PK infections. Materials and methods This cohort study was conducted on naval rating cadets with a clinical diagnosis of PK at Chumpol Naval Rating School, Thailand in 2016. Read More

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November 2018
1 Read

Critical Illness Scoring Systems: Sequential Organ Failure Assessment, Acute Physiology and Chronic Health Evaluation II, and Quick Sequential Organ Failure Assessment to Predict the Clinical Outcomes in Scrub Typhus Patients with Organ Dysfunctions.

Indian J Crit Care Med 2018 Oct;22(10):706-710

Department of Nephrology, PGIMER, Chandigarh, India.

Background And Aim: Scrub typhus (ST) is an acute infectious disease of variable severity caused by (formerly ) . The disease can be complicated by organ dysfunctions and the case fatality rate (CFR) is approximately 15%, which further rises with the development of severe complications. We studied the clinical features of the ST and the performance of critical illness scoring systems (CISSs) - Acute Physiology and Chronic Health Evaluation (APACHE) II, sequential organ failure assessment (SOFA), and quick SOFA (qSOFA) in predicting the clinical outcomes in complicated ST (cST) patients admitted to the emergency department. Read More

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October 2018
10 Reads

A case report of scrub typhus complicated with myocarditis and rhabdomyolysis.

BMC Infect Dis 2018 Nov 7;18(1):551. Epub 2018 Nov 7.

Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea.

Background: Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi, a gram-negative intracellular bacterium. Myocarditis and rhabdomyolysis are rare complications of scrub typhus.

Case Presentation: We report a case of scrub typhus, which was simultaneously complicated with myocarditis and rhabdomyolysis. Read More

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November 2018
1 Read

Current challenges in the development of vaccines and drugs against emerging vector-borne diseases.

Authors:
Kwang-Sun Kim

Curr Med Chem 2018 Nov 5. Epub 2018 Nov 5.

Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241. Korea.

Vectors are living organisms that transmit infectious diseases from an infected animal to humans or another animal. Biological vectors such as mosquitoes, ticks, and sand flies carry pathogens that multiply within their bodies prior to delivery to a new host. The increased prevalence of vector-borne diseases (VBDs) such as Aedes-borne dengue, Chikungunya (CHIKV), Zika (ZIKV), malaria, tick-borne disease (TBD), and scrub typhus has a huge impact on the health of both humans and livestock worldwide. Read More

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November 2018
9 Reads

Seroprevalence of spotted fever group and typhus group rickettsiae in individuals with acute febrile illness from Gorakhpur, India.

Int J Infect Dis 2018 Nov 1. Epub 2018 Nov 1.

Indian Council of Medical Research, New Delhi, India.

Background: Our aim was to estimate the seroprevalence of spotted fever group (SFG) and typhus group (TG) rickettsiae among individuals with acute febrile illness (AFI) in the scrub typhus endemic Gorakhpur district, India; one of the worst affected by annual seasonal acute encephalitis syndrome (AES) outbreaks.

Methods: Antibodies against SFG and TG rickettsiae and the associated risk factors were determined in 294 individuals presenting with AFI, encountered during a community based survey conducted during AES outbreak period October-November 2016.

Results: IgM and IgG seropositivity for SFG was 13. Read More

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November 2018
1 Read
2.330 Impact Factor

A surface antigen of activates human monocyte-derived dendritic cells via nuclear factor-kB & p38 mitogen-activated protein kinase pathways.

Indian J Med Res 2018 Aug;148(2):215-224

Institute of Medical Sciences, Tzu Chi University, Chia Yi, Taiwan.

Background & Objectives: Scrub typhus is a chigger-borne disease caused by Orientia tsutsugamushi. The immunological reactions to O. tsutsugamushi infection are not completely understood. Read More

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August 2018
2 Reads

Anti-aquaporin-4 Antibody Positive Optic Neuritis Following Scrub Typhus in an Elderly Female.

Neurologist 2018 Nov;23(6):183-184

Department of Neurology, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Gyeonggi-do, Korea.

Introduction: Aquaporin-4 antibody (AQP4-Ab) is specific for neuromyelitis optica spectrum disorder (NMOSD) and so is helpful to distinguish NMOSD from other autoimmune diseases. Several viral infections may play a role in the onset of NMOSD.

Case Report: We describe a case of a previous healthy 82-year-old woman who presented with acute visual loss occurring 3 weeks after scrub typhus. Read More

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November 2018
4 Reads

Patient and operating room staff radiation dose during fenestrated/branched endovascular aneurysm repair using premanufactured devices.

J Vasc Surg 2018 Nov 28;68(5):1281-1286. Epub 2018 Jun 28.

Division of Vascular and Endovascular Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Tex.

Introduction: Fenestrated endovascular aneurysm repair (FEVAR) is the highest radiation dose procedure performed by vascular surgeons. We sought to characterize the radiation dose to patients and staff during FEVAR procedures with different premanufactured devices.

Methods: A single-center prospective study of FEVARs was performed over 24 months. Read More

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November 2018

Hemophagocytic lymphohistiocytosis with neurological manifestations in an infant with scrub typhus: a rare fatal occurrence.

Trop Doct 2018 Oct 26:49475518804696. Epub 2018 Oct 26.

4 Director Professor and Head, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of unchecked activation of the immune system leading to phagocytosis of blood cells and proliferation of histiocytes in solid organs. HLH can be primary or secondary to infective, autoimmune and malignant conditions. Scrub typhus is an infective illness caused by Orientia tsutsugamushi, transmitted by mite. Read More

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October 2018
7 Reads

Skin preparation for preventing infection following caesarean section.

Cochrane Database Syst Rev 2018 10 22;10:CD007462. Epub 2018 Oct 22.

Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, DR.Sardjito Hospital, Jl. Kesehatan No.1, Sekip, Yogyakarta, Daerah Istimewa Yogyakarta, Indonesia, 55281.

Background: The risk of maternal mortality and morbidity (particularly postoperative infection) is higher for caesarean section (CS) than for vaginal birth. With the increasing rate of CS, it is important to minimise the risks to the mother as much as possible. This review focused on different forms and methods of preoperative skin preparation to prevent infection. Read More

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October 2018
7 Reads

Targeting metabolic pathways proteins of Orientia tsutsugamushi using combined hierarchical approach to combat scrub typhus.

J Mol Recognit 2018 Oct 21:e2766. Epub 2018 Oct 21.

ICAR-Indian Veterinary Research Institute, Regional Station, Palampur, Himachal Pradesh, India.

Orientia tsutsugamushi (Ott) is a causative agent of chigger-borne zoonosis, scrub typhus which is life threatening and highly pervasive illness in humans. In this report, we have mined and classified the proteins involved in pathways unique to Ott by using high-throughput computational techniques. The 12 metabolic pathways were found to be unique to the pathogen. Read More

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October 2018
4 Reads
2.150 Impact Factor

Effectiveness of surgical hand antisepsis using chlorhexidine digluconate and parachlorometaxylenol hand scrub: Cross-over trial.

Medicine (Baltimore) 2018 10;97(42):e12831

Facultad de Enfermeria y Podologia Universidade A Coruña. Spain.

Background: Chlorhexidine and parachlorometaxylenol (PCMX) are antiseptics recommended for surgical hand antisepsis. To our knowledge, PCMX has not been evaluated for bactericidal efficacy "in vivo.

Methods: We conducted a randomized, double-blind, controlled crossover trial to compare the bacterial loads on fingertips and fingernails under laboratory conditions after use of antiseptic test products, including chlorhexidine digluconate 4%, PCMX 3%, and a reference solution of propan-1-ol 60% (P-1). Read More

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October 2018
3 Reads

Identification of B- and T-cell epitopes on HtrA protein of Orientia tsutsugamushi.

J Cell Biochem 2018 Oct 15. Epub 2018 Oct 15.

Sri Sakthi Amma Institute of Biomedical Research, Sri Narayani Hospital and Research Centre, Vellore, Tamil Nadu, India.

Orientia tsutsugamushi, a cause of scrub typhus is emerging as an important pathogen in several parts of the tropics. The control of this infection relies on rapid diagnosis, specific treatment, and prevention through vector control. Development of a vaccine for human use would be very important as a public health measure. Read More

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October 2018
9 Reads
3.260 Impact Factor

A new species of Rhadinella (Serpentes: Dipsadidae) from the dry forest of Motagua Valley, Guatemala.

Zootaxa 2018 Jul 2;4442(2):338-344. Epub 2018 Jul 2.

Centro de Estudios Ambientales y Biodiversidad, Universidad del Valle de Guatemala, 11 calle 15-79 z.15 V.H. III, Ciudad de Guatemala, Guatemala Department of Natural Sciences and Environmental Health, Faculty of Technology, Natural Sciences and Maritime Sciences, University of Southeast Norway, 3800 Bø, Telemark, Norway.

We describe a new species of Rhadinella from the dry forest and thorn scrub of Valle del Motagua, Guatemala, a region and habitat where the congeners were previously unrecorded. This species is related to the group of Rhadinella that have dark dorsal coloration, which mostly or completely obscures a pattern of longitudinal striping characteristic of the majority of species of Rhadinella. The new species has dark gray, almost black, dorsal coloration with barely discernible slightly darker striping. Read More

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A new species of grass spider, Agelenopsis riechertii, from the Southwestern USA, with notes on its courtship behavior (Araneae: Agelenidae).

Zootaxa 2018 Jul 3;4442(4):579-583. Epub 2018 Jul 3.

569 Dabney Hall, 1416 Circle Drive, Knoxville, TN 37996..

We describe a new spider species of the genus Agelenopsis Giebel 1869 (Agelenidae) from adult males and females. Agelenopsis riechertii is found in dry desert scrub habitats in the southwestern United States. While A. Read More

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July 2018
1 Read

Case Report: Concurrent Sympatric Scrub Typhus and Japanese Spotted Fever in Japan.

Am J Trop Med Hyg 2018 Oct 8. Epub 2018 Oct 8.

Department of Clinical Medicine, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.

Scrub typhus and Japanese spotted fever-both rickettsial diseases-are endemic and notifiable in Japan and may cause a fatal outcome without prompt treatment. Here we present the first case of a concurrent sympatric infection of both diseases with grade II evidence. A 67-year-old woman, after a single event of potential exposure to the pathogens, presented with a 12-day history of fever, pharyngeal pain, papulo-erythematous rash, and pronounced fatigue. Read More

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October 2018
3 Reads

Novel high-throughput screening method using quantitative PCR to determine the antimicrobial susceptibility of Orientia tsutsugamushi clinical isolates.

J Antimicrob Chemother 2018 Oct 6. Epub 2018 Oct 6.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.

Objectives: To develop a method to enable the large-scale antimicrobial susceptibility screening of Orientia tsutsugamushi clinical isolates, using one timepoint and one concentration of antibiotics to considerably speed up the time to result.

Methods: Growth, harvesting, multiplicity of infection (moi) and the day to determine the MICs were optimized using five O. tsutsugamushi reference strains [susceptible (Karp, Kato and Gilliam) and putatively resistant (AFC-3 and AFSC-4)], one clinical isolate (UT76) and one rodent isolate (TA763). Read More

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October 2018
7 Reads

Understanding drivers of human-leopard conflicts in the Indian Himalayan region: Spatio-temporal patterns of conflicts and perception of local communities towards conserving large carnivores.

PLoS One 2018 5;13(10):e0204528. Epub 2018 Oct 5.

Wildlife Institute of India, Dehradun, Uttarakhand, India.

Human killing is the decisive and most critical expression of human-leopard conflict and needs to be addressed sensitively to maintain local support for leopard conservation in India. This research was undertaken to investigate the ecological aspects of human killing and injury, spatial characteristic and pattern of such sites, temporal and seasonal trends of attacks and perception of local communities towards leopard in the Indian Himalayan region (IHR). We surveyed two sites i) Pauri Garhwal in the western part and ii) North Bengal (Dooars) in the eastern part of IHR, compiled secondary data on human-leopard conflict records and made field visits to (N = 101) conflict sites. Read More

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October 2018
3 Reads

Assessment of shared alleles in drought-associated candidate genes among southern California white oak species (Quercus sect. Quercus).

BMC Genet 2018 Oct 1;19(1):88. Epub 2018 Oct 1.

Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, 90095-7239, USA.

Background: Hybridization and introgression are common phenomena among oak species. These processes can be beneficial by introducing favorable genetic variants across species (adaptive introgression). Given that drought is an important stress, impacting physiological and morphological variation and limiting distributions, our goal was to identify drought-related genes that might exhibit patterns of introgression influenced by natural selection. Read More

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October 2018
1 Read

Mycoplasmosis of House Finches ( Haemorhous mexicanus) and California Scrub-Jays ( Aphelocoma californica) in a Wildlife Rehabilitation Facility with Probable Nosocomial Transmission.

J Wildl Dis 2018 Oct 4. Epub 2018 Oct 4.

3 California Animal Health and Food Safety Laboratory System, University of California, Davis, 620 W Health Sciences Dr., Davis, California 95616, USA.

We describe an investigation of an outbreak of conjunctivitis in juvenile House Finches ( Haemorhous mexicanus) and California Scrub-jays ( Aphelocoma californica) at a central California wildlife rehabilitation facility. In late May 2015, the facility began admitting juvenile finches, the majority with normal eyes at intake. In June, with juvenile finches already present, the facility admitted additional juvenile scrub-jays, again all with normal eyes at intake. Read More

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October 2018

Identification and Characterization of Orientia chuto in Trombiculid Chigger Mites Collected from Wild Rodents in Kenya.

J Clin Microbiol 2018 Dec 27;56(12). Epub 2018 Nov 27.

U.S. Army Medical Research Directorate-Kenya/Kenya Medical Research Institute, Kisumu, Kenya

We present data that concurs with the reported geographical expansion of scrub typhus outside the "Tsutsugamushi Triangle" and addition of as a second species in the genus. Wild rodents were caught in Marigat, Baringo County, Kenya, and ectoparasites, including chiggers, were recovered. Rodent and chigger species were identified by taxonomic features. Read More

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December 2018
6 Reads
3.990 Impact Factor

Serological evidence of spotted fever group rickettsiosis in and around Puducherry, south India-A three years study.

J Vector Borne Dis 2018 Apr-Jun;55(2):144-150

Department of General Medicine and Microbiology, Indira Gandhi Govt. General Hospital and Post Graduate Institute, Puducherry, India.

Background & Objectives: Rickettsial diseases are important re-emerging infections that mostly go unnoticed or are misdiagnosed. Though few case reports of Indian tick typhus have been reported in Indian literature in the past 10 yr, prevalence surveys are few and far between. The objective of this research was to study the seroprevalence of spotted fever (SF) group rickettsiosis and its coinfection with scrub typhus (ST) in Puducherry region of south India, as these two diseases may show similar clinical presentations. Read More

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October 2018
1 Read

Coinfections as an aetiology of acute undifferentiated febrile illness among adult patients in the sub-Himalayan region of north India.

J Vector Borne Dis 2018 Apr-Jun;55(2):130-136

Department of Medicine, Dr Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India.

Background & Objectives: In India, certain geographic regions witness simultaneous outbreaks of two or more diseases like scrub typhus, dengue fever, malaria, leptospirosis and chikungunya during monsoon and post-monsoon period, sharing common indication of acute febrile illness. The objective of the present study was to assess the prevalence of coinfections among patients with acute undifferentiated fevers (AUF) admitted in a tertiary care hospital in the northern hilly state of Himachal Pradesh, India.

Methods: This was a hospital based open cohort study conducted over a period of two months (September and October) in 2016. Read More

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October 2018
3 Reads

Relationships Between Expertise, Crew Familiarity and Surgical Workflow Disruptions: An Observational Study.

World J Surg 2018 Oct 2. Epub 2018 Oct 2.

Department of Neurosurgery, Rennes University Hospital, 2, rue Henri Le Guilloux, 35033, Rennes Cedex 9, France.

Background: Teamwork is an essential factor in reducing workflow disruption (WD) in the operating room. Team familiarity (TF) has been recognized as an antecedent to surgical quality and safety. To date, no study has examined the link between team members' role and expertise, TF and WD in surgical setting. Read More

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October 2018
4 Reads

Diagnostic Accuracy of the InBios Scrub Typhus Detect™ ELISA for the Detection of IgM Antibodies in Chittagong, Bangladesh.

Trop Med Infect Dis 2018 Sep 1;3(3). Epub 2018 Sep 1.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithee Road, Bangkok 10400, Thailand.

Here we estimated the accuracy of the InBios Scrub Typhus Detect™ immunoglobulin M (IgM) ELISA to determine the optimal optical density (OD) cut-off values for the diagnosis of scrub typhus. Patients with undifferentiated febrile illness from Chittagong, Bangladesh, provided samples for reference testing using (i) qPCR using the spp. 47-kDa gene, (ii) IFA ≥1:3200 on admission, (iii) immunofluorescence assay (IFA) ≥1:3200 on admission or 4-fold rise to ≥3200, and (iv) combination of PCR and IFA positivity. Read More

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September 2018
6 Reads

Serological Cross-Reactivity among Serotypes but Not with in Japan.

Trop Med Infect Dis 2018 Jul 5;3(3). Epub 2018 Jul 5.

Mahara Institute of Medical Acarology, Tokushima 779-1510, Japan.

The rickettsial diseases Japanese spotted fever (JSF) and scrub typhus (ST) are caused by and , respectively. The diseases share clinical symptoms, such as fever, rash, and eschar. However, there are no systematical investigations of the serological cross-reactivity between and . Read More

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July 2018
4 Reads

Outer Membrane Protein A Conservation among Isolates Suggests Its Potential as a Protective Antigen and Diagnostic Target.

Trop Med Infect Dis 2018 Jun 11;3(2). Epub 2018 Jun 11.

Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, VA 23298, USA.

Scrub typhus threatens one billion people in the Asia-Pacific area and cases have emerged outside this region. It is caused by infection with any of the multitude of strains of the bacterium . A vaccine that affords heterologous protection and a commercially-available molecular diagnostic assay are lacking. Read More

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June 2018
2 Reads

Hemophagocytic Lymphohistiocytosis Associated with Scrub Typhus: Systematic Review and Comparison between Pediatric and Adult Cases.

Trop Med Infect Dis 2018 Feb 14;3(1). Epub 2018 Feb 14.

Stroke Center, Jichi Medical University 3311-1, Yakushiji, Shimotsuke-city, Tochigi 329-0498, Japan;

Background: Scrub typhus is a mite-borne bacterial infection caused by . Hemophagocytic lymphohistiocytosis (HLH) is a potential severe complication. Most reported cases of HLH associated with scrub typhus were single cases or case series with a small sample sizes. Read More

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February 2018
2 Reads