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Osong Public Health Res Perspect 2021 Apr 29;12(2):126-135. Epub 2021 Apr 29.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.

Objective: The aims of this study were to analyze the characteristics of the 100 top-cited articles on scrub typhus (ST), and to assess the present research landscape and future research directions using bibliometric analysis.

Methods: Web of Science was used to conduct a bibliometric analysis of the 100 top-cited articles on ST. The articles were analyzed by publication year, number of citations, document type, journals, keywords, institutions, country of origin, and authorship. Read More

World J Clin Cases 2021 May;9(13):3194-3199

Department of Physical Medicine and Rehabilitation, University of Ulsan College of Medicine, Ulsan University Hospital, Dong-gu 44033, Ulsan, South Korea.

Background: It is difficult to restore the cognitive functions of patients with impaired cognition caused by brain injury. Diffusion tensor imaging can visualize the integrity of neural tracts in the white matter (WM) three-dimensionally. It is unclear whether encephalitis following scrub typhus damages the WM. Read More

BMJ Case Rep 2021 May 6;14(5). Epub 2021 May 6.

Neurology, Institute of Postgraduate Medical Education and Research Bangur Institute of Neurology, Kolkata, India.

Tropical pyomyositis manifests as single or multiple abscesses inside skeletal muscles and it has a higher prevalence in immunocompromised patients. Scrub typhus, a zoonotic disease is caused by and the clinical manifestations range from simple febrile illness to organ threatening complications. Here, we present a rare case of an immunocompetent young man diagnosed as tropical pyomyositis in association with scrub typhus. Read More

Trop Doct 2021 May 6:494755211012585. Epub 2021 May 6.

Assistant Professor, Department of Community Medicine, 483691Indira Gandhi Medical College and Research Institute, Pondicherry, India.

Pulmonary involvement is common in children with scrub typhus. Our paper outlines the clinical characteristics of pulmonary involvement and analyses the predictors of its severity. All scrub typhus serology-positive (optical density >0. Read More

Asia Pac J Public Health 2021 May 3:10105395211012907. Epub 2021 May 3.

Tribhuvan University, Kirtipur, Kathmandu, Nepal.

Int J Environ Res Public Health 2021 Apr 26;18(9). Epub 2021 Apr 26.

The Collaboration Unit for Field Epidemiology of State Key Laboratory of Infectious Disease Prevention and Control, Nanchang Center for Disease Control and Prevention, Nanchang 330038, China.

: Scrub typhus (ST) has become a significant potential threat to public health in Jiangxi. Further investigation is essential for the control and management of the spatiotemporal patterns of the disease. : Time-series analyses, spatial distribution analyses, spatial autocorrelation analysis, and space-time scan statistics were performed to detect spatiotemporal dynamics distribution of the incidence of ST. Read More

Pathogens 2021 Apr 2;10(4). Epub 2021 Apr 2.

Department of Microbiology, College of Medicine, Korea University, Seoul 02841, Korea.

An epidemiological investigation was conducted for a scrub typhus case reported in a U.S. Forces Korea military patient in the Republic of Korea in November 2018. Read More

Pathogens 2021 Apr 1;10(4). Epub 2021 Apr 1.

Department of Microbiology, Maharajgunj Medical Campus, Institute of Medicine, Kathmandu 44600, Nepal.

Scrub typhus is a vector-borne, acute febrile illness caused by . Scrub typhus continues to be an important but neglected tropical disease in Nepal. Information on this pathogen in Nepal is limited to serological surveys with little information available on molecular methods to detect . Read More

J Mov Disord 2021 May 3. Epub 2021 May 3.

Department of Neurology, Lady Hardinge Medical College, New Delhi, India.

PLoS Negl Trop Dis 2021 Apr 29;15(4):e0009185. Epub 2021 Apr 29.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Background: The mechanisms that control local and systemic inflammation in scrub typhus have only been partially elucidated. The wingless (Wnt) signaling pathways are emerging as important regulators of inflammation and infection, but have not been investigated in scrub typhus.

Methodology/principal Findings: Plasma levels of secreted Wnt antagonists (i. Read More

Indian J Ophthalmol 2021 May;69(5):1167-1171

Prasad Netralaya, Udupi, Karnataka, India.

Purpose: The aim of this work was to study the ocular manifestations and its management in spotted fever and typhus group of rickettsial disease.

Methods: A retrospective analysis of 50 patients with serologically confirmed Rickettsial disease. In all patients, relevant history, investigations and treatment details were collected and they underwent complete ophthalmic evaluation including measurement of best-corrected visual acuity, anterior segment examination and dilated fundus examination. Read More

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Neuro-Medicine, KPC Medical College and Hospital, Jadavpur, West Bengal, India

This is a rare presentation of scrub typhus with cerebral venous thrombosis. A 32-year-old woman presented with signs of raised intracranial tension. Examination revealed maculopapular skin rashes and an 'eschar' over the right thigh. Read More

Indian J Med Res 2021 Mar;153(3):375-381

ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu; Division of Epidemiology and Communicable Diseases Division , Indian Council of Medical Research, New Delhi, India.

Gorakhpur division consisting of Gorakhpur and neighboring districts Deoria, Kushinagar and Maharajganj in Uttar Pradesh, India, have been witnessing seasonal outbreaks of acute encephalitis syndrome (AES) among children for the last three decades. Investigations conducted during 2005 identified Japanese encephalitis (JE) virus as an aetiology of AES. With the introduction of JE vaccination and other control strategies, the incidence of JE in the region declined, however, outbreaks of acute febrile illness with neurological manifestations continued to occur. Read More

Indian J Med Res 2021 Mar;153(3):358-366

Department of Community Medicine, Armed Forces Medical College, Pune, Maharashtra, India.

India is perilously poised on the threshold of an explosion of infectious diseases, some of which have witnessed re-emergence while others await apposite opportunity to do so. The State of West Bengal is uniquely positioned with its innate geographical vulnerabilities that favour outbreaks of a host of infectious diseases. The northern districts of this State are well known endemic areas for many outbreak prone communicable diseases like malaria, Japanese encephalitis, scrub typhus, dengue and kala-azar. Read More

Indian J Med Res 2021 Mar;153(3):320-326

ICAR-National Research Centre on Meat, Hyderabad, Telangana, India.

Background & Objectives: Issues such as emerging and re-emerging infectious diseases, antimicrobial resistance, food security, biosafety and biosecurity are associated with changes in land use, population growth, urbanization, global travel and trade and climate change. As a result, a trans-disciplinary approach among human, animal and environmental health disciplines gained support. The Indian Council of Medical Research (ICMR) and Indian Council of Agricultural Research (ICAR) decided to establish a National Institute of One Health at Nagpur, Maharashtra, India. Read More

Trans R Soc Trop Med Hyg 2021 Apr 23. Epub 2021 Apr 23.

ICMR-Regional Medical Research Centre, Bhubaneswar 751023, Odisha, India.

Background: Acute encephalitis syndrome (AES) is a major public health concern in India, causing febrile illness principally associated with viral infection. Bacteria-like scrub typhus and leptospirosis also cause acute febrile illness. Therefore, this study was conceived to address the possible etiological agents contributing to sporadic AES in a tertiary care center in Odisha, India. Read More

IDCases 2021 26;24:e01086. Epub 2021 Mar 26.

Department of Internal Medicine, Post Graduate Institute of Medical Education and Medical Research, Chandigarh, India.

A 60-year-old female presented to the emergency room with fever and myalgias for four days and shortness of breath for two days. On clinical examination, she was tachypneic and blood oxygen saturation of 86 % on room air. There was an eschar of size 1 × 1 cm on the left infraclavicular area (Fig. Read More

J Glob Infect Dis 2020 Oct-Dec;12(4):238-239. Epub 2020 Nov 30.

Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

Indian Pediatr 2021 Apr;58(4):367-369

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic Rochester, MN, USA.

Objective: To study manifestations and outcome of scrub typhus in infants.

Methods: Case record analysis of infants with scrub typhus admitted to a tertiary care hospital, diagnosed by IgM ELISA from January 1, 2016 to December 31, 2019.

Results: Out of 374 children diagnosed with scrub typhus, 34 (9%) were infants. Read More

J Clin Microbiol 2021 Apr 21. Epub 2021 Apr 21.

Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, Republic of Korea.

This study was carried out to evaluate the accuracy of various antibody tests for scrub typhus, namely the indirect immunofluorescence assay (IFA) from the Korea Centers for Disease Control and Prevention (KCDC) and four commercial kits (companies A-D). The test accuracy was based on the diagnosis of scrub typhus, as defined by a positive polymerase chain reaction or culture. In total, serum samples from 97 patients with scrub typhus and 200 non-scrub typhus patients were tested. Read More

PLoS Negl Trop Dis 2021 Apr 19;15(4):e0009355. Epub 2021 Apr 19.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Background: Current knowledge on Rickettsia felis infection in humans is based on sporadic case reports. Here we conducted a retrospective seroepidemiological survey of R. felis infection among febrile patients visiting a medical center in Taipei. Read More

Travel Med Infect Dis 2021 Apr 17;42:102062. Epub 2021 Apr 17.

Department of Infectious/Tropical Diseases and Microbiology (DITM), IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy. Electronic address:

Background: Scrub typhus is a vector-borne rickettsial infection, which can cause relevant morbidity and mortality. While the number of cases is around a million per year globally, the infection is seldom diagnosed in travellers from Europe.

Methods: We herein report three cases diagnosed in Italian travellers and review the literature about imported cases in Europe in the last 60 years. Read More

Mil Med 2021 Apr 16. Epub 2021 Apr 16.

Viral and Rickettsial Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA.

Introduction: Leptospirosis and rickettsial diseases are global zoonotic diseases. In severe infection cases, mortality can range from 10% to 30%. Currently most epidemiological data available are based on outbreak investigations and hospital-based studies from endemic countries. Read More

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

General Medicine, Jawaharlal Institute of Postgraduate Medical Education, Puducherry, Tamil Nadu, India.

PLoS Negl Trop Dis 2021 Apr 15;15(4):e0009339. Epub 2021 Apr 15.

Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, Unites States of America.

Background: Scrub typhus is a neglected tropical disease that threatens more than one billion people. If antibiotic therapy is delayed, often due to mis- or late diagnosis, the case fatality rate can increase considerably. Scrub typhus is caused by the obligate intracellular bacterium, Orientia tsutsugamushi, which invades phagocytes and endothelial cells in vivo and diverse tissue culture cell types in vitro. Read More

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Internal Medicine, Baby Memorial Hospital, Calicut, Kerala, India.

Scrub typhus is an acute febrile disease transmitted via bites from mite larvae (chigger) infected with Orientia tsutsugamushi. Arrhythmias, ischaemic changes and QT prolongation are some of the observed ECG abnormalities. The patient being reported presented with angina and was found to have sinus bradycardia with ST elevation in inferior leads and T wave inversion in lateral leads. Read More

J Postgrad Med 2021 Apr-Jun;67(2):117-118

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education, Puducherry, India.

A 23-year-old primigravida at 20 weeks of gestation presented to our hospital with undifferentiated febrile illness and severe acute respiratory distress syndrome. She was intubated in the emergency department and transferred to the intensive care unit. Initial treatment included ventilatory care, vasopressor support and broad-spectrum antibiotics. Read More

Exp Appl Acarol 2021 May 7;84(1):171-182. Epub 2021 Apr 7.

Infectious Diseases Research Centre, Institute for Medical Research (IMR), National Institutes of Health, Ministry of Health Malaysia, Acarology Unit, Jalan Setia Murni U13/52, Seksyen U13, Setia Alam, 40170, Shah Alam, Selangor, Malaysia.

Orientia tsutsugamushi is the causative agent of scrub typhus vectored by larval stages of trombiculid mites (chiggers) that occur in most tropical regions of Southeast Asia. A total of 242 chiggers extracted from eight small mammals captured from a positive scrub typhus locality in Kelantan, Malaysia, were screened for the presence of O. tsutsugamushi. Read More

Cells 2021 Mar 5;10(3). Epub 2021 Mar 5.

Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Jeonbuk 54531, Korea.

Scrub typhus is a fatal zoonotic disease caused by . This disease is accompanied by systemic vasculitis, lymphadenopathy, headache, myalgia, and eschar. In recent studies, a novel strain that is resistant to current medical treatment was identified in Thailand. Read More