Search our Database of Scientific Publications and Authors

I’m looking for a

    2044 results match your criteria Scrub Typhus

    1 OF 41

    Effects of Rifampin and Doxycycline Treatments in Patients with Uncomplicated Scrub Typhus: An Open-label Randomized Controlled Trial.
    Clin Infect Dis 2018 Feb 15. Epub 2018 Feb 15.
    Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea.
    Background: Doxycycline is currently the most frequently used treatment in patients with scrub typhus, but doxycycline-resistant strains have been found, necessitating the development of a new treatment. Rifampin is known to be effective even for such strains. Thus, this study aimed to compare the effects of rifampin and doxycycline treatment in patients with scrub typhus in areas in which resistance to doxycycline has not been reported. Read More

    Aetiology of acute encephalitis syndrome in Uttar Pradesh, India from 2014 to 2016.
    J Vector Borne Dis 2017 Oct-Dec;54(4):311-316
    Department of Microbiology, King George's Medical University, Lucknow, India.
    Background & Objectives: It is imperative to know the aetiology of acute encephalitis syndrome (AES) for patient management and policy making. The present study was carried out to determine the prevalence of common aetiological agents of AES in Uttar Pradesh (UP) state of India.

    Methods: Serum and/or CSF samples were collected from AES patients admitted at Gandhi Memorial and Associated Hospital, King George's Medical University, Lucknow, a tertiary care centre, UP during 2014-16. Read More

    Clinical proteomic analysis of scrub typhus infection.
    Clin Proteomics 2018 14;15. Epub 2018 Feb 14.
    1Drug & Disease Target Team, Korea Basic Science Institute (KBSI), Cheongju, 28119 Republic of Korea.
    Background: Scrub typhus is an acute and febrile infectious disease caused by the Gram-negative α-proteobacteriumfrom the family Rickettsiaceae that is widely distributed in Northern, Southern and Eastern Asia. In the present study, we analysed the serum proteome of scrub typhus patients to investigate specific clinical protein patterns in an attempt to explain pathophysiology and discover potential biomarkers of infection.

    Methods: Serum samples were collected from three patients (before and after treatment with antibiotics) and three healthy subjects. Read More

    Dysregulated Th1 Immune and Vascular Responses in Scrub Typhus Pathogenesis.
    J Immunol 2018 Feb;200(4):1233-1240
    Department of Microbiology and Immunology, Center for Tropical Diseases, Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, Institute of Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555; and
    Scrub typhus is an emerging, insect-transmitted disease caused bya Gram- and LPS-negative bacterium that replicates freely within professional phagocytes and endothelial cells. Scrub typhus is prevalent with high mortality rates, but information regarding its molecular pathogenesis, microbial virulence determinants, and key immune responses is limited. Improved animal models have recently been developed that respectively resemble the pathological features of self-limiting or severe scrub typhus in humans. Read More

    Spectrum of cardiac manifestations and its relationship to outcomes in patients admitted with scrub typhus infection.
    World J Crit Care Med 2018 Feb 4;7(1):16-23. Epub 2018 Feb 4.
    Medical Intensive Care Unit, Christian Medical College, Vellore 632004, India.
    Aim: To study the spectrum of cardiac manifestations in scrub typhus infection and assess its relationship to outcomes.

    Methods: Demographic data, electrocardiographic (ECG) changes, left ventricular (LV) systolic and diastolic function, myocardial injury (defined as troponin T > 14 pg/mL), and pericardial effusion were documented. Myocarditis was diagnosed when myocardial injury was associated with global LV systolic dysfunction. Read More

    Spectrum of infections in acute febrile illness in central India.
    Indian J Med Microbiol 2017 Oct-Dec;35(4):480-484
    Department of Microbiology, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India.
    Introduction: Infectious agent when enters in the host results in febrile illness. This may lead to increase in morbidity or even mortality in undiagnosed/untreated cases. There are many aetiological agents which lead to acute febrile illness. Read More

    Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis.
    Indian Pediatr 2018 Jan;55(1):35-37
    Departments of Paediatrics, Christian Medical College, Vellore, Tamil Nadu, India. Correspondence to: Dr. Winsley Rose, Professor, Department of Paediatrics, Christian Medical College, Vellore 632004, Tamilnadu, India.
    Objective: To compare scrub typhus meningitis with bacterial and tuberculous meningitis.

    Methods: Children aged <15 years admitted with meningitis were screened and those who fit criteria for diagnosis of scrub typhus meningitis (n=48), bacterial meningitis (n=44) and tuberculous meningitis (n=31) were included for analysis. Clinical features, investigations and outcomes were compared between the three types of meningitis. Read More

    An Update on Host-Pathogen Interplay and Modulation of Immune Responses during Orientia tsutsugamushi Infection.
    Clin Microbiol Rev 2018 Apr 31;31(2). Epub 2018 Jan 31.
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
    The obligate intracellular bacteriumis the causative agent of scrub typhus in humans, a serious mite-borne disease present in a widespread area of endemicity, which affects an estimated 1 million people every year. This disease may exhibit a broad range of presentations, ranging from asymptomatic to fatal conditions, with the latter being due to disseminated endothelial infection and organ injury. Unique characteristics of the biology and host-pathogen interactions of, including the high antigenic diversity among strains and the highly variable, short-lived memory responses developed by the host, underlie difficulties faced in the pursuit of an effective vaccine, which is an imperative need. Read More

    [Epidemiology of scrub typhus and influencing factors in Yunnan province, 2006-2013].
    Zhonghua Liu Xing Bing Xue Za Zhi 2018 Jan;39(1):54-57
    State Key Laboratory of Pathogen and Bio-security, Institute of Microbiology and Epidemiology, Academy of Military Medical Science, Beijing 100071, China.
    To understand the epidemiological characteristics of scrub typhuand influencing factors in Yunnan province, and provide further information for the prevention and control of scrub typhus.Based on the incidence data of scrub typhus reported in Yunnan from 2006 to 2013, the epidemiological characteristics of scrub typhus were analyzed and related environmental factors were identified with panel negative binomial regression model.A total of 8 980 scrub typhus cases were reported during 2006-2013 in Yunnan. Read More

    Predictors of Severity in Pediatric Scrub Typhus.
    Indian J Pediatr 2018 Jan 24. Epub 2018 Jan 24.
    Department of Pediatrics, Indira Gandhi Medical College and Research Institute (IGMC&RI), Pondicherry, India.
    Objective: To identify the factors that can predict the severity of scrub typhus in children.

    Methods: This prospective study was conducted at a tertiary care teaching hospital between November 2014 to October 2016. All children <12y of age admitted with fever for more than 7d and positive IgM ELISA for scrub typhus were included in the study. Read More

    is highly susceptible to the RNA polymerase switch region inhibitor Corallopyronin Aand.
    Antimicrob Agents Chemother 2018 Jan 22. Epub 2018 Jan 22.
    Dept. of Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
    Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacteriumReports on the emergence of doxycycline-resistant strains highlight the urgent need to develop novel anti-infectives against scrub typhus.Corallopyronin A (CorA) is a novel α-pyrone compound synthesized by the myxobacteriumand was characterized as a non-competitive inhibitor of the "switch region" of bacterial RNA polymerase (RNAP). We investigated the antimicrobial action of CorA against the human-pathogenic Karp strain ofandThe minimal inhibitory concentration of CorA againstwas remarkably low (0. Read More

    Acute transverse myelitis following scrub typhus: A case report and review of the literature.
    J Spinal Cord Med 2018 Jan 19:1-4. Epub 2018 Jan 19.
    a Department of Neurosurgery , Chonnam National University Hospital and Medical School, Biomedical Research Institute , Gwangju , Korea.
    Context Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi. The disease can usually involve the lungs, heart, liver, spleen and brain through hematogenous dissemination. However, very rarely, acute transverse myelitis in the spinal cord develops from scrub typhus. Read More

    Scrub Typhus Outbreak in Chonburi Province, Central Thailand, 2013.
    Emerg Infect Dis 2018 Feb;24(2):361-365
    Investigation of a scrub typhus outbreak in Thailand during September 2013 found that 9.1% of Thai soldiers and 11.1% of residents living in areas surrounding training sites had antibodies against the causative agent, Orientia tsutsugamushi. Read More

    Molecular Epidemiology of anGene Encoding a 56-kDa Type-Specific Antigen in Chiggers, Small Mammals, and Patients from the Southwest Region of Korea.
    Am J Trop Med Hyg 2018 Feb 4;98(2):616-624. Epub 2018 Jan 4.
    Division of Infectious disease investigation, Health and Environment Research Institute of Gwangju City, Gwangju, Korea.
    A phylogenetic analysis ofwas performed to elucidate its antigenic diversity in chiggers, small mammals, and patients. Between September 2014 and December 2016, a total of 3,816 chiggers were identified within nine species of four genera in the southwest region of Korea:(49.9%; 1,907/3,816),(21. Read More

    Tropical Fevers in Indian Intensive Care Units: A Prospective Multicenter Study.
    Indian J Crit Care Med 2017 Dec;21(12):811-818
    Professor Emeritus Pathology, PGIMS, Rohtak, Haryana, India.
    Background And Aims: Infections in tropics often present as undifferentiated fevers with organ failures. We conducted this nationwide study to identify the prevalence, profile, resource utilization, and outcome of tropical fevers in Indian Intensive Care Units (ICUs).

    Materials And Methods: This was a multicenter prospective observational study done in 34 ICUs across India (July 2013-September 2014). Read More

    Differentiation of severe fever with thrombocytopenia syndrome from scrub typhus.
    Clin Infect Dis 2017 Dec 25. Epub 2017 Dec 25.
    Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    We developed a severe fever with thrombocytopenia syndrome (SFTS) differentiation score in the cohort including 21 patients with SFTS and 91 patients with scrub typhus. This scoring using criteria (score > 1) of altered mental status, leukopenia, prolonged aPTT, and normal CRP provided 100% sensitivity and 97% specificity for SFTS. Read More

    Clinical Profile of Scrub Typhus Meningoencephalitis among South Indian Children.
    J Trop Pediatr 2017 Dec 18. Epub 2017 Dec 18.
    Department of Community Medicine, Indira Gandhi Medical College and Research Institute, 255, Vazhudavoor Road, Kathirkamam, Puducherry 605009, India.
    Re-emerging scrub typhus is gaining recognition as an important cause of paediatric meningoencephalitis in tropics. We studied the clinical profile of scrub typhus meningoencephalitis (STME) in children <12 years. Of 270 serology-confirmed cases of scrub typhus, 14 (5%) had features consistent with STME and 9 (64%) of these children were between 5 and 12 years of age; 12 (85%) children presented to the hospital during the second week of illness. Read More

    Longevity of antibody and T-cell responses against outer membrane antigens of Orientia tsutsugamushi in scrub typhus patients.
    Emerg Microbes Infect 2017 Dec 20;6(12):e116. Epub 2017 Dec 20.
    Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
    Scrub typhus, caused by Orientia tsutsugamushi infection, has been a serious public health issue in the Asia-Pacific region, with rising incidence and sporadic outbreaks. However, human protective immunity against specific antigens has been poorly characterized for this bacterium. In addition, immunity produced in early vaccine trials or even after natural infections, did not last long and had poor cross-reactivity among various genotypes. Read More

    Drug treatment of scrub typhus: a systematic review and meta-analysis of controlled clinical trials.
    Trans R Soc Trop Med Hyg 2017 Aug;111(8):336-344
    Department of Pathology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
    Scrub typhus, a potentially fatal infection caused by the pathogen Orientia tsutsugamushi, has a wide geographical distribution. This systematic review analyses the evidence from prospective controlled clinical studies for the efficacy of antibiotics in the treatment of scrub typhus. PubMed, Embase, Scopus, Cochrane Library, CINAHL and clinical trial registries in China, India and Sri Lanka were searched for controlled prospective clinical trials (randomized, quasi-randomized or non-randomized) enrolling patients with confirmed scrub typhus for treatment with antibiotics. Read More

    Renal Manifestation in Scrub Typhus during a Major Outbreak in Central Nepal.
    Indian J Nephrol 2017 Nov-Dec;27(6):440-445
    Health Services Research, United Health Group, OptumInsight, CT, USA.
    Renal involvement and acute kidney injury (AKI) are common clinical manifestations seen in scrub typhus, a vector-borne tropical disease. There are no data on renal manifestation in scrub typhus in Nepal. We conducted a prospective study to analyze the incidence, urinary abnormalities, course, severity, outcome, and the predictors of AKI in patients with scrub typhus during a major outbreak in Central Nepal. Read More

    Rapid Diagnosis of Tick-Borne Illnesses by Use of One-Step Isothermal Nucleic Acid Amplification and Bio-Optical Sensor Detection.
    Clin Chem 2017 Dec 5. Epub 2017 Dec 5.
    Departments of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
    Background: Scrub typhus and severe fever with thrombocytopenia syndrome (SFTS) are the most common tick-borne illnesses in South Korea. Early differentiation of SFTS from scrub typhus in emergency departments is essential but difficult because of their overlapping epidemiology, shared risk factors, and similar clinical manifestations.

    Methods: We compared the diagnostic performance of one-step isothermal nucleic acid amplification with bio-optical sensor detection (iNAD) under isothermal conditions, which is rapid (20-30 min), with that of real-time PCR, in patients with a confirmed tick-borne illness. Read More

    Guillain-Barre Syndrome with Falciparum Malaria and Scrub Typhus Mixed Infection-An Unusual Combination.
    J Clin Diagn Res 2017 Sep 1;11(9):OD10-OD11. Epub 2017 Sep 1.
    Professor, Department of Medicine, Kasturba Hospital, Manipal University, Manipal, Karnataka, India.
    Guillain-Barre Syndrome is very rare in parasitic and rickettsial infection. Here we report a case of Plasmodium falciparum and scrub typhus mixed infection, presented with quadriparesis. Clinical, Serological, CSF analysis and Nerve Conduction Studies were consistent with Acute Inflammatory Demyelinating Polyneuropathy (variant of GBS). Read More

    Seroprevalence of rickettsial infections and Q fever in Bhutan.
    PLoS Negl Trop Dis 2017 Nov 27;11(11):e0006107. Epub 2017 Nov 27.
    Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.
    Background: With few studies conducted to date, very little is known about the epidemiology of rickettsioses in Bhutan. Due to two previous outbreaks and increasing clinical cases, scrub typhus is better recognized than other rickettsial infections and Q fever.

    Methodology: A descriptive cross-sectional serosurvey was conducted from January to March 2015 in eight districts of Bhutan. Read More

    Epidemiological, clinical and laboratory profile of scrub typhus cases detected by serology and RT-PCR in Kumaon, Uttarakhand: a hospital-based study.
    Trop Doct 2017 01 1:49475517743891. Epub 2017 Jan 1.
    6 Assistant Professor, Department of Microbiology, Government Medical College, Haldwani, Nainital, Uttarakhand, India.
    We analysed the epidemiology, clinical and laboratory data of the 168 scrub typhus cases confirmed by a combination of any one of the following: real time polymerase chain reaction (RT-PCR) and/or immunofluorescence assay (IFA) (IgM and/or IgG). The peak season for scrub typhus is from July to October. By multivariate binary logistic regression analysis, the risk of scrub typhus was about four times in those working in occupation related to forest work. Read More

    Differences in agricultural activities related to incidence of scrub typhus between Korea and Japan.
    Epidemiol Health 2017 9;39:e2017051. Epub 2017 Nov 9.
    Department of Preventive Medicine and Public Health, Wonkwang University School of Medicine, Iksan, Korea.
    Objectives: The purpose of this study was to establish a basis for improving or strengthening the preventive strategy against scrub typhus in Korea by comparing and analyzing the difference of prevention behaviors contributing to the occurrence of scrub typhus in Japan and Korea.

    Methods: The survey was carried out in Jeollabuk-do, which is a high risk and high incidence area, and Fukuoka Prefecture, which is a high risk and low incidence area. The study included 406 Korean farmers and 216 Japanese farmers. Read More

    modulates endoplasmic reticulum-associated degradation to benefit its growth.
    Infect Immun 2017 Nov 6. Epub 2017 Nov 6.
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, 23298-0678, USA
    , an obligate intracellular bacterium that is auxotrophic for the aromatic amino acids and histidine, causes scrub typhus, a potentially deadly infection that threatens one billion people.growth is minimal during the first 24 to 48 h of infection, but becomes logarithmic thereafter. How the pathogen modulates cellular functions to support its growth is poorly understood. Read More

    Chigger Mite (Acari: Trombiculidae) Survey of Rodents in Shandong Province, Northern China.
    Korean J Parasitol 2017 Oct 31;55(5):555-559. Epub 2017 Oct 31.
    Shandong Academy of Medicine Sciences, Shandong Institute of Parasitic Diseases, Jining, Shandong Province 272033, People's Republic of China.
    Chigger mites are parasites of rodents and other vertebrates, invertebrates, and other arthropods, and are the only vectors of scrub typhus, in addition to other zoonoses. Therefore, investigating their distribution, diversity, and seasonal abundance is important for public health. Rodent surveillance was conducted at 6 districts in Shandong Province, northern China (114-112°E, 34-38°N), from January to December 2011. Read More

    A review of the global epidemiology of scrub typhus.
    PLoS Negl Trop Dis 2017 Nov 3;11(11):e0006062. Epub 2017 Nov 3.
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas, United States of America.
    Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi, scrub typhus can result in severe multiorgan failure with a case fatality rate up to 70% without appropriate treatment. Read More

    Differential diagnosis of scrub typhus meningitis from tuberculous meningitis using clinical and laboratory features.
    Clin Neurol Neurosurg 2017 Dec 23;163:76-80. Epub 2017 Oct 23.
    Department of Internal Medicine, Malabar Institute of Medical Sciences, Calicut, Kerala, India.
    Objectives: The involvement of the central nervous system in the form of meningitis or meningoencephalitis is common in scrub typhus and is an important differential diagnosis of other lymphocytic meningitis like tuberculous meningitis (TBM). The aim of this study was to identify the clinical and laboratory parameters that may be helpful in differentiating scrub typhus meningitis from TBM.

    Patients And Methods: We compared of the clinical and laboratory features of 57 patients admitted with scrub typhus meningitis or TBM during a 3-year period. Read More

    Relative Bradycardia in Scrub Typhus.
    Am J Trop Med Hyg 2017 Nov 10;97(5):1316-1318. Epub 2017 Oct 10.
    Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea.
    To investigate the relationship between heart rate and temperature, we examined 493 febrile patients with documented disease. These patients were diagnosed serologically and analyzed retrospectively: 337 (68.4%) responded to fever with increased heart rate < 10 beats/minute/°C (relative bradycardia [RB]), and 156 patients had a heart rate response ≥ 10 beats/minute/°C (general heart rate increase [GHRI]). Read More

    Immune thrombocytopenia with multi-organ dysfunction syndrome as a rare presentation of scrub typhus: a case report.
    BMC Res Notes 2017 Oct 6;10(1):496. Epub 2017 Oct 6.
    M.O.S.C Medical College & Hospital, Ernakulam District, Kolenchery, Kerala, 682311, India.
    Background: Scrub typhus is an acute infectious illness caused by Orientia tsutsugamushi. It is endemic to a part of the world known as the "tsutsugamushi triangle". Humans are accidental hosts in this zoonotic disease. Read More

    New Record of the Scrub Typhus Vector, Leptotrombidium rubellum, in Southwest China.
    J Med Entomol 2017 Nov;54(6):1767-1770
    Vector Laboratory, Institute of Pathogens and Vectors, Dali University, and the Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Dali, Yunnan Province 671000, P. R. China.
    There are several main vectors of scrub typhus in China, and Leptotrombidium rubellum Wang et Liao, 1984 is one of them, which was previously considered to be restricted to the coastal regions of Changle to Xiamen, Fujian province of east China. Ecological investigation of chigger mites in recent years demonstrated the presence of L. rubellum also in Yunnan province. Read More

    Scrub Typhus in Southern Districts of West Bengal.
    Indian J Dermatol 2017 Sep-Oct;62(5):512-514
    Department of Dermatology, R G Kar Medical College, Kolkata, West Bengal, India.
    Scrub typhus has been previously reported from north and eastern Indian states and areas such as Kashmir, Himachal Pradesh, Assam, Sikkim, and Darjeeling district of West Bengal. It has also been known to be endemic in some parts of South India (Eastern and Western Ghats). However, no cases have ever been reported from the southern districts of West Bengal. Read More

    Scrub Typhus: An Emerging Threat.
    Indian J Dermatol 2017 Sep-Oct;62(5):478-485
    Department of Dermatology, Dr. B. C. Roy Postgraduate Institute of Pediatric Science, Kolkata, West Bengal, India.
    Scrub typhus is caused by(formerly) and is transmitted to humans by an arthropod vector of thefamily (and). It is the most common re-emerging Rickettsial infection in India and many other South East Asian countries. In fact, scrub typhus is confined geographically to the Asia Pacific region, a billion people are at risk and nearly a million cases are reported every year. Read More

    Acute undifferentiated fever in India: a multicentre study of aetiology and diagnostic accuracy.
    BMC Infect Dis 2017 10 4;17(1):665. Epub 2017 Oct 4.
    Infectious Diseases Training and Research Centre, Department of Medicine, Christian Medical College, Vellore, India.
    Background: The objectives of this study were to determine the proportion of malaria, bacteraemia, scrub typhus, leptospirosis, chikungunya and dengue among hospitalized patients with acute undifferentiated fever in India, and to describe the performance of standard diagnostic methods.

    Methods: During April 2011-November 2012, 1564 patients aged ≥5 years with febrile illness for 2-14 days were consecutively included in an observational study at seven community hospitals in six states in India. Malaria microscopy, blood culture, Dengue rapid NS1 antigen and IgM Combo test, Leptospira IgM ELISA, Scrub typhus IgM ELISA and Chikungunya IgM ELISA were routinely performed at the hospitals. Read More

    Scrub Typhus in a New Born.
    J Clin Diagn Res 2017 Aug 1;11(8):SD05-SD06. Epub 2017 Aug 1.
    Senior Resident, Department of Paediatrics, Chacha Nehru Bal Chikitsalaya, Delhi, India.
    Scrub typhus is an acute febrile mite-born rickettsial infection caused by(formely called. This infection is very uncommon in neonates. We report a case of 19-day-old newborn presenting with clinical features mimicking severe sepsis but was subsequently diagnosed with primary scrub typhus infection. Read More

    Improving the Diagnosis of Scrub Typhus by CombiningBased Polymerase Chain Reaction and IgM ELISA.
    J Clin Diagn Res 2017 Aug 1;11(8):DC27-DC31. Epub 2017 Aug 1.
    Senior Technical officer, Department of Statistics, Regional Medical Research Centre, Belagavi, Karnataka, India.
    Introduction: Scrub typhus, an acute febrile illness, caused by, is an important cause of pyrexia of unknown origin in regions of endemicity. This disease is mostly underdiagnosed or misdiagnosed, the reasons for this being a combination of factors which include clinical manifestations that can mimic other infections, lack of easy and reliable diagnostic methods and variation among strains in endemic areas. Hence, easy and reliable methods of diagnosis will contribute to rapid identification and treatment of the infection. Read More

    Estimating the burden of scrub typhus: A systematic review.
    PLoS Negl Trop Dis 2017 Sep 25;11(9):e0005838. Epub 2017 Sep 25.
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
    Background: Scrub typhus is a vector-borne zoonotic disease that can be life-threatening. There are no licensed vaccines, or vector control efforts in place. Despite increasing awareness in endemic regions, the public health burden and global distribution of scrub typhus remains poorly known. Read More

    Prevalence and Phylogenetic Analysis of Orientia tsutsugamushi in Rodents and Mites from Central India.
    Vector Borne Zoonotic Dis 2017 11 21;17(11):749-754. Epub 2017 Sep 21.
    1 Centre for Zoonoses, Department of Veterinary Public Health, Nagpur Veterinary College, Maharashtra Animal and Fishery Sciences University , Nagpur, India .
    Orientia tsutsugamushi, the causative agent of scrub typhus in humans, is an obligate intracytosolic bacterium transmitted among animals and to humans by some species of larval trombiculid mites (chiggers) and is hosted mainly by rodents. In this study, we attempted detection of O. tsutsugamushi from blood and tissue samples of rodents trapped from different locations in Central India using PCR targeting the 56 kDa outer membrane protein gene and the 47 kDa high temperature transmembrane protein gene. Read More

    Zoonotic surveillance for rickettsiae in rodents and mapping of vectors of rickettsial diseases in India: A multi-centric study.
    Indian J Public Health 2017 Jul-Sep;61(3):174-181
    Junior Scientific Assistant, Department of Community Medicine, Armed Forces Medical College, Pune, Maharashtra, India.
    Background: The global resurgence of rickettsial diseases and their potential to impact the fitness of military personnel and inflict widespread casualties amongst civil populations has emerged as a major cause of public health concern. Absence of surveillance system, lack of awareness amongst medical fraternity to rickettsial activity along with the difficulty in diagnosis because of their protean clinical manifestations are reasons for the outbreaks of these diseases.

    Objectives: To determine rickettsial activity amongst rodents and study vector diversity, abundance and their distribution to enable mapping of rickettsial hotspots. Read More

    Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen ELISpot assay in rhesus macaques and humans.
    PLoS Negl Trop Dis 2017 Sep 11;11(9):e0005846. Epub 2017 Sep 11.
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
    Scrub typhus is a febrile infection caused by the obligate intracellular bacterium Orientia tsutsugamushi, which causes significant morbidity and mortality across the Asia-Pacific region. The control of this vector-borne disease is challenging due to humans being dead-end hosts, vertical maintenance of the pathogen in the vector itself, and a potentially large rodent reservoir of unclear significance, coupled with a lack of accurate diagnostic tests. Development of an effective vaccine is highly desirable. Read More

    Typhoid and Scrub Typhus Coinfection in a Returned Traveler.
    Glob Pediatr Health 2017 25;4:2333794X17726941. Epub 2017 Aug 25.
    KK Women's and Children's Hospital, Singapore, Singapore.
    This is a case report of a 12-year-old returned traveler with typhoid and scrub typhus coinfection. The diagnosis of typhoid was made early with blood cultures and Widal Weil Felix serology. Persistent fever despite appropriate antibiotics for typhoid fever prompted a search for concomitant infection, which led to the diagnosis of scrub typhus confirmed byserology. Read More

    Comparative effectiveness of azithromycin for treating scrub typhus: A PRISMA-compliant systematic review and meta-analysis.
    Medicine (Baltimore) 2017 Sep;96(36):e7992
    aDepartment of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City bDepartment of Pediatrics, MacKay Children's Hospital, Taipei cMacKay Medical College, New Taipei dDepartment of Medical Technology, Jen-Teh Junior college of Medicine, Nursing and Management, Miaoli eDivision of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan fDepartment of Medicine, National Yang-Ming University gBiobank Management Center of the Tri-Service General Hospital, National Defense Medical Center hDepartment of Pathology and Graduate Institute of Pathology and Parasitology, the Tri-Service General Hospital, National Defense Medical Center iGraduate Institute of Life Sciences, National Defense Medical Center, Taipei jDepartment of Pathology & Laboratory Medicine, Hsinchu Mackay Memorial Hospital, Hsinchu City, Taiwan kDivision of Infection and Pathway Medicine, College of Medicine and Veterinary Medicine, the University of Edinburgh, Scotland, UK.
    Background: Scrub typhus is a zoonotic disease that remains an important health threat in endemic areas. Appropriate anti-rickettsial treatment ensures a successful recovery. Doxycycline is a recommended drug, but it is contraindicated in pregnant women and young children. Read More

    Validation of Geno-Sen's Scrub Typhus Real Time Polymerase Chain Reaction Kit by its Comparison with a Serological ELISA Test.
    J Glob Infect Dis 2017 Jul-Sep;9(3):108-112
    Department of Genomics and Proteomics, Central Interdisciplinary Research Facility, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.
    Background: In the recent past, scrub typhus (ST) has been reported from different parts of India, based on Weil-Felix/enzyme-linked immunosorbent assay (ELISA)/indirect immunofluorescence assay (IFA). Molecular tests are applied only by a few researchers.

    Aims: Evaluation of a new commercial real time polymerase chain reaction (PCR) kit for molecular diagnosis of ST by comparing it with the commonly used IgM ELISA is our aim. Read More

    1 OF 41