164,949 results match your criteria Screening and Diagnostic Tests


Understanding quality of life and treatment history of patients with Bertolotti syndrome compared with lumbosacral radiculopathy.

J Neurosurg Spine 2019 Apr 19:1-7. Epub 2019 Apr 19.

4Center for Spine Health, Department of Neurosurgery, Neurologic Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

OBJECTIVEBertolotti syndrome is a rare spinal condition that causes low-back pain due to a lumbosacral transitional vertebra (LSTV), which is a pseudoarticulation between the fifth lumbar transverse process and the sacral ala. Bertolotti syndrome patients are rarely studied, particularly with regard to their quality of life. This study aimed to examine the quality of life and prior treatments in patients with Bertolotti syndrome at first presentation to the authors' center in comparison with those with lumbosacral radiculopathy. Read More

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http://dx.doi.org/10.3171/2019.2.SPINE1953DOI Listing

Maspin differential expression patterns as a potential marker for targeted screening of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma.

PLoS One 2019 19;14(4):e0215089. Epub 2019 Apr 19.

Department of Oncology, Wayne State University School of Medicine, Detroit, United States of America.

Aim: Barrett's esophagus (BE) is a predisposing factor of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma (ECA/GEJ Aca). BE patients are stratified and subsequently monitored according to the risk of malignant progression by the combination of endoscopy and biopsy. This study is to evaluate the maspin expression patterns as early diagnostic markers of malignancy in BE patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215089PLOS

Assessing for Fetal Alcohol Spectrum Disorder.

J Popul Ther Clin Pharmacol 2019 Jan 23;26(1):e39-e55. Epub 2019 Jan 23.

Canada FASD Research Network.

Background The recommended "gold standard" for Fetal Alcohol Spectrum Disorder (FASD) assessment involves a multidisciplinary diagnostic team and comprehensive battery of neuropsychological tests to evaluate functioning across 10 brain domains. The current Canadian Guideline for diagnosis of FASD outlines a list of test measures for assessment; however, very little research exists to explore which specific tools are being used in clinical practice. Objectives The purpose of the current study was to gain a better understanding of the testing measures used by FASD clinicians in Alberta, Canada. Read More

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http://jptcp.com/index.php/jptcp/article/view/54
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http://dx.doi.org/10.22374/1710-6222.26.1.4DOI Listing
January 2019
1 Read

A multicenter validation study for the EU-TIRADS using histological diagnosis as a gold standard.

Clin Endocrinol (Oxf) 2019 Apr 19. Epub 2019 Apr 19.

Thyroid Imaging and Cytopathology Centre, Paris, France.

Objective: Many systems for risk stratification of thyroid nodule with ultrasound (US) have been proposed and the EU-TIRADS issued by the ETA in 2017 was the last to have been published. The present study was undertaken to evaluate if the malignancy risk of each category corresponded to the given range of the guidelines and assess the diagnostic value of EU-TIRADS in a multi-institutional trial with histology as gold standard.

Design: Three institutions in Switzerland, France, and United Kingdom shared this retrospective study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13997
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http://dx.doi.org/10.1111/cen.13997DOI Listing
April 2019
1 Read

Value of PCR, Serology, and Blood Smears for Human Granulocytic Anaplasmosis Diagnosis, France.

Emerg Infect Dis 2019 May;25(5):996-998

We prospectively examined the effectiveness of diagnostic tests for anaplasmosis using patients with suspected diagnoses in France. PCR (sensitivity 0.74, specificity 1) was the best-suited test. Read More

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http://dx.doi.org/10.3201/eid2505.171751DOI Listing

Study of hepatitis E virus ORF2 antigen kinetics in human-liver chimeric mice and its impact on HEV diagnosis.

J Infect Dis 2019 Apr 18. Epub 2019 Apr 18.

Laboratory of Liver Infectious Diseases, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Background: Hepatitis E virus infection (HEV) is an emerging problem in developed countries. Diagnosis of HEV infection is based on the detection of HEV-specific antibodies, viral RNA and/or antigens (Ag). Humanized mice were previously reported as a model for the study of HEV infection, but published data was focused on the quantification of viral RNA. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz171DOI Listing
April 2019
1 Read

Applying Machine Learning of Erythrocytes Dynamic Antigens Store in Medicine.

Front Mol Biosci 2019 3;6:19. Epub 2019 Apr 3.

Computer Science Department, Faculty of Computing and Information Technology, King Abdulaziz University, Jeddah, Saudi Arabia.

Erythrocytes Dynamic Antigens Store (EDAS) is a new discovery. EDAS consists of self-antigens and foreign (non-self) antigens. In patients with infectious diseases or malignancies, antigens of infection microorganism or malignant tumor exist in EDAS. Read More

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https://www.frontiersin.org/article/10.3389/fmolb.2019.00019
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http://dx.doi.org/10.3389/fmolb.2019.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456707PMC
April 2019
1 Read

Over Expressed TKTL1, CIP-2A, and B-MYB Proteins in Uterine Cervix Epithelium Scrapings as Potential Risk Predictive Biomarkers in HR-HPV-Infected LSIL/ASCUS Patients.

Front Oncol 2019 3;9:213. Epub 2019 Apr 3.

Human Histology and Embryology Unit, University of Verona Medical School, Verona, Italy.

High oncogenic risk human papillomaviruses (HR-HPVs) promote cervical carcinoma development, the fourth most common feminine cancer. A slow oncodevelopmental phase-defined histopathologically as Cervical Intraepithelial Neoplasia (CIN) grades 1-3, or cytologically as Low- or High-grade Squamous Intraepithelial Lesions (LSIL or HSIL)-precedes the malignancy. Cervical carcinoma screenings through HR-HPV genotyping and Pap smears are regularly performed in Western countries. Read More

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http://dx.doi.org/10.3389/fonc.2019.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456695PMC

Functional and Objective Audiovestibular Evaluation of Children With Apparent Semicircular Canal Dehiscence-A Case Series in a Pediatric Vestibular Center.

Front Neurol 2019 2;10:306. Epub 2019 Apr 2.

Department of Paediatric Audiology and Audiovestibular Medicine, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom.

Semicircular canal dehiscence is a bony abnormality in the otic capsule especially involving the superior semicircular canal. Since its identification in 1998, there is significant research regarding the pathology in the adult population. This condition generates a third window effect that is well-described in the literature. Read More

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http://dx.doi.org/10.3389/fneur.2019.00306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454049PMC

Detection of anti-Trypanosoma cruzi antibodies by chimeric antigens in chronic Chagas disease-individuals from endemic South American countries.

PLoS One 2019 18;14(4):e0215623. Epub 2019 Apr 18.

Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.

Background: Laboratory diagnosis of chronic Chagas disease is a troubling factor due to lack of reference tests. The WHO suggests the use of two distinct commercial serological tests in parallel. The performance of commercial immunoassays might fluctuate depending on the antigenic matrices and the local strains of T. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215623PLOS

What Is the Diagnostic Accuracy of Alpha-Defensin and Leukocyte Esterase Test in Periprosthetic Shoulder Infection?

Clin Orthop Relat Res 2019 Apr 3. Epub 2019 Apr 3.

N. U. Ecker, A. Koniker, T. Gehrke, A. Zahar, M. Citak, Helios ENDO-Klinik Hamburg, Department of Orthopaedic Surgery, Hamburg, Germany A. Koniker, J. Salber, Ruhr-University Bochum, Department of General Surgery, Bochum, Germany M. Hentschke, MVZ Labor Dr. Fenner und Kollegen, Hamburg, Germany.

Background: The diagnosis of periprosthetic joint infection (PJI) after total shoulder arthroplasty (TSA) is challenging, especially in patients with Cutibacterium (formerly Propionibacterium) acnes infection. Despite the increasing number of patients with PJI of the shoulder, there are still no robust data regarding diagnostic tests in detecting shoulder PJI.

Questions/purposes: (1) What are the sensitivity, specificity, and negative- and positive-predictive values for the alpha-defensin enzyme-linked immunosorbent assay test in detecting PJI after TSA? (2) What are the diagnostic accuracies in detecting shoulder PJI for synovial alpha-defensin, leukocyte esterase Test, and serum C-reactive protein (CRP)?

Methods: All patients with painful TSA, who underwent joint aspiration to validate or exclude a PJI, between July 2015 and February 2018 were enrolled in this single-center study. Read More

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http://Insights.ovid.com/crossref?an=00003086-900000000-9820
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http://dx.doi.org/10.1097/CORR.0000000000000762DOI Listing
April 2019
2 Reads

Case 265: Lemmel Syndrome or Biliary Obstruction Due to a Periampullary Duodenal Diverticulum.

Radiology 2019 May;291(2):542-545

From the Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608.

History A 70-year-old man presented to the emergency department with fever, chills, rigors, and upper abdominal discomfort. Physical examination revealed jaundice and mild right upper quadrant tenderness. Laboratory tests revealed an increased C-reactive protein level of 133 mg/L (normal range, 0. Read More

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http://pubs.rsna.org/doi/10.1148/radiol.2019162375
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http://dx.doi.org/10.1148/radiol.2019162375DOI Listing
May 2019
1 Read

The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update.

Neth Heart J 2019 Apr 17. Epub 2019 Apr 17.

Durrer Centre for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands.

Background: Clinical research on arrhythmogenic cardiomyopathy (ACM) is typically limited by small patient numbers, retrospective study designs, and inconsistent definitions.

Aim: To create a large national ACM patient cohort with a vast amount of uniformly collected high-quality data that is readily available for future research.

Methods: This is a multicentre, longitudinal, observational cohort study that includes (1) patients with a definite ACM diagnosis, (2) at-risk relatives of ACM patients, and (3) ACM-associated mutation carriers. Read More

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http://link.springer.com/10.1007/s12471-019-1270-1
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http://dx.doi.org/10.1007/s12471-019-1270-1DOI Listing
April 2019
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[Laboratory tests for kidney disease].

Authors:
G M Fiedler B Vogt

Internist (Berl) 2019 Apr 17. Epub 2019 Apr 17.

Universitätsklinik für Nephrologie und Hypertonie, Inselspital, Universitätsspital Bern, Universität Bern, 3010, Bern, Schweiz.

Kidney diseases are among the most frequently reported diseases with a poor prognosis that are diagnosed too late. According to current Kidney Disease Improving Global Outcomes (KDIGO) guidelines, diagnosis and risk stratification are mainly based on functional markers (creatinine and cystatin C), which are used to determine the estimated glomerular filtration rate (eGFR) and the analysis of urinary albumin excretion as a marker of kidney damage. These methods have limitations that can complicate the interpretation of the results and can lead to a delay of the diagnosis as well as to a misinterpretation of the prognosis. Read More

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http://dx.doi.org/10.1007/s00108-019-0598-3DOI Listing

CPHLN recommendations for the laboratory detection of Shiga toxin-producing (O157 and non-O157).

Can Commun Dis Rep 2018 Nov 1;44(11):304-307. Epub 2018 Nov 1.

National Microbiology Laboratory, MB & ON.

Shiga toxin-producing (STEC) are important enteric pathogens responsible for sporadic cases and outbreaks of gastroenteritis. O157:H7/NM (STEC O157) are the most commonly known STEC serotypes but it is now increasingly apparent that non-O157 STEC serotypes have been underreported in the past because they were not part of routine screening in many front-line laboratories. The Canadian Public Health Laboratory Network (CPHLN) has identified the need for improved detection and surveillance of non-O157 STEC and has developed the following recommendations to assist in the decision-making process for clinical and reference microbiology laboratories. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v44i11a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449107PMC
November 2018
2 Reads

Construction of the safe neutralizing assay system using pseudotyped Nipah virus and G protein-specific monoclonal antibody.

Biochem Biophys Res Commun 2019 Apr 14. Epub 2019 Apr 14.

Department of Biomedical Science and Engineering, Konkuk University, Seoul, 05029, Republic of Korea; Department of Bio-industrial Technologies, Konkuk University, Seoul, 05029, Republic of Korea. Electronic address:

Nipah virus (NiV) is a recently emerged paramyxovirus that causes acute respiratory illness and fatal encephalitis in a broad spectrum of vertebrates, including humans. Due to its high pathogenicity and mortality rates, NiV requires handling in biosafety level-4 (BSL-4) containment facilities and no effective vaccines or therapeutic agents are currently available. Since current diagnostic tests for detecting serum neutralizing antibodies against NiV mainly employ live viruses, establishment of more safe and robust alternative diagnostic methods is an essential medical requirement. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.212DOI Listing

A review on screening tests for vestibular disorders.

Authors:
Helen S Cohen

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Bobby R Alford Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, United States.

Although many studies have reported on tests of the vestibular system a valid and reliable, evidence-based screening battery for easy clinical use remains elusive. Many screening tests attempt to assess the vestibulo-ocular reflex. Therefore, head shaking, the Dix-Hallpike maneuver, the supine roll test and head impulse tests are discussed. Read More

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https://www.physiology.org/doi/10.1152/jn.00819.2018
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http://dx.doi.org/10.1152/jn.00819.2018DOI Listing
April 2019
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The Leukocyte Esterase Test for Periprosthetic Joint Infection Is Not Affected by Prior Antibiotic Administration.

J Bone Joint Surg Am 2019 Apr;101(8):739-744

The Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Background: It has been demonstrated that administration of antibiotics prior to performing diagnostic testing for periprosthetic joint infection can interfere with the accuracy of the standard diagnostic tests. Therefore, the purpose of this study was to evaluate the effects of antibiotic administration prior to performing the synovial leukocyte esterase strip test for periprosthetic joint infection.

Methods: We identified 121 patients who underwent revision hip or knee arthroplasty for a Musculoskeletal Infection Society (MSIS)-confirmed periprosthetic joint infection. Read More

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http://dx.doi.org/10.2106/JBJS.18.00615DOI Listing

Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing

Inadequate diagnostics: the case to move beyond the bacilli for detection of meningitis due to Mycobacterium tuberculosis.

J Med Microbiol 2019 Apr 17. Epub 2019 Apr 17.

3 University of Minnesota, Minneapolis, MN, USA.

Tuberculosis (TB) meningitis is extremely difficult to diagnose due to its pauci-bacillary disease nature and new techniques are needed. Improved test sensitivity would allow for greater clinician confidence in diagnostic testing and has the potential to improve patient outcomes. Traditional microbiologic and molecular tests for TB meningitis focus on detection of TB bacilli and are inadequate. Read More

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http://dx.doi.org/10.1099/jmm.0.000975DOI Listing
April 2019
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A Direct from Blood/Plasma Reverse Transcription-Polymerase Chain Reaction for Dengue Virus Detection in Point-of-Care Settings.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada.

Infection with dengue virus (DENV) is widespread across tropical regions and can result in severe disease. Early diagnosis is important both for patient management and to differentiate infections that present with similar symptoms, such as malaria, chikungunya, and Zika. Rapid diagnostic tests that are used presently for point-of-care detection of DENV antigens lack the sensitivity of molecular diagnostics that detect viral RNA. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0138DOI Listing

Gynecology Imaging Reporting and Data System (GI-RADS): diagnostic performance and inter-reviewer agreement.

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology, Zagazig University, Zagazig, Egypt.

Objective: To evaluate diagnostic performance and inter-reviewer agreement (IRA) of the Gynecologic Imaging Reporting and Data System (GI-RADS) for diagnosis of adnexal masses (AMs) by pelvic ultrasound (US).

Patients And Methods: A prospective multicenter study included 308 women (mean age, 41 ± 12.5 years; range, 15-73 years) with 325 AMs detected by US. Read More

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http://dx.doi.org/10.1007/s00330-019-06181-0DOI Listing

Chronic lower leg pain: entrapment of common peroneal nerve or tibial nerve.

Unfallchirurg 2019 Apr 16. Epub 2019 Apr 16.

Departments of Surgery, Neurology and Sports Medicine, Maxima Medical Center, De Run 4600, 7777, 5500 MB, Veldhoven, The Netherlands.

Young individuals with chronic exercise-induced lower leg pain (ELP) who have normal compartmental muscle pressures and normal imaging occasionally suffer from a nerve entrapment syndrome. These patients have consistently undergone a variety of diagnostic tests and often futile therapies prior to arriving at the correct diagnosis. Awareness among traumatologists regarding these nerve entities is low. Read More

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http://link.springer.com/10.1007/s00113-019-0645-5
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http://dx.doi.org/10.1007/s00113-019-0645-5DOI Listing
April 2019
1 Read

Informational needs of pregnant women following the prenatal diagnosis of fetal anomalies: A qualitative study in Iran.

J Educ Health Promot 2019 15;8:30. Epub 2019 Feb 15.

Department of Health Sciences, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: An appropriate exchange of information between the health-care provider and the family is an important component of coping with stress following the prenatal diagnosis of fetal anomalies. Therefore, this study was conducted to explore the informational needs of pregnant women following a prenatal diagnosis of fetal anomalies in Mashhad, Iran.

Subjects And Methods: This qualitative, conventional, content analysis study was designed through two referral centers for fetal anomaly. Read More

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http://dx.doi.org/10.4103/jehp.jehp_199_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432835PMC
February 2019

Aberrant DNA methylation as a diagnostic biomarker of diabetic embryopathy.

Genet Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

Purpose: Maternal diabetes is a known teratogen that can cause a wide spectrum of birth defects, collectively referred to as diabetic embryopathy (DE). However, the pathogenic mechanisms underlying DE remain uncertain and there are no definitive tests to establish the diagnosis. Here, we explore the potential of DNA methylation as a diagnostic biomarker for DE and to inform disease pathogenesis. Read More

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http://www.nature.com/articles/s41436-019-0516-z
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http://dx.doi.org/10.1038/s41436-019-0516-zDOI Listing
April 2019
1 Read

Developing a Brief Neuropsychological Battery for Early Diagnosis of Cognitive Impairment.

Authors:
Tau Ming Liew

J Am Med Dir Assoc 2019 Apr 13. Epub 2019 Apr 13.

Department of Geriatric Psychiatry, Institute of Mental Health, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:

Objectives: Early diagnosis of cognitive impairment is increasingly emphasized in the literature to facilitate timely preventive interventions. Although bedside cognitive tests such as the Montreal Cognitive Assessment (MoCA) are widely used for such early diagnostic purposes, they may not have comparable performance to a full neuropsychological battery (FNB) in diagnosing early cognitive impairment. This study investigated whether a small subset of neuropsychological tests can be added on to MoCA to match its performance to that of the FNB in discriminating mild cognitive impairment and dementia (MCI/dementia) from normal cognition. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15258610193026
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http://dx.doi.org/10.1016/j.jamda.2019.02.028DOI Listing
April 2019
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First outbreak of Oropouche Fever reported in a non-endemic western region of the Peruvian Amazon. Molecular diagnosis and clinical characteristics.

Int J Infect Dis 2019 Apr 13. Epub 2019 Apr 13.

School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Centro de Salud Las Palmas - Red de Salud Leoncio Prado - Ministerio de Salud, Huánuco, Peru. Electronic address:

Introduction: Oropouche fever is an under-reported and emerging infectious disease caused by Oropouche virus (OROV). Its incidence is under-estimated mainly due to clinical similarities with other endemic arboviral diseases and the lack of specific diagnostic tests. We report the first outbreak of Oropouche fever in a western region of the Peruvian Amazon in Huanuco, Peru. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.011DOI Listing

"It's not a time spent issue, it's a 'what have you spent your time doing?' issue…" A qualitative study of UK patient opinions and expectations for implementation of Point of Care Tests for sexually transmitted infections and antimicrobial resistance.

PLoS One 2019 16;14(4):e0215380. Epub 2019 Apr 16.

St George's University of London, Institute for Infection and Immunity, Applied Diagnostic Research and Evaluation Unit, London, United Kingdom.

Sexually transmitted infections (STIs) continue to be a major public health concern in the United Kingdom (UK). Epidemiological models have shown that narrowing the time between STI diagnosis and treatment may reduce the population burden of infection, and rapid, accurate point-of-care tests (POCTs) have potential for increasing correct treatment and mitigating the spread of antimicrobial resistance (AMR). We developed the Precise social science programme to incorporate clinician and patient opinions on potential designs and implementation of new POCTs for multiple STIs and AMR detection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215380PLOS

Smartphone-based home screening tests for male infertility.

Panminerva Med 2019 Jun;61(2):104-107

American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic Foundation, Cleveland, OH, USA.

Diagnostic testing for male infertility has traditionally been limited to andrology labs. The advent of home-based semen testing has the potential to allow patients to perform testing in the comfort of their home and screen those who need a formal evaluation. An extensive review of the literature was performed. Read More

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https://www.minervamedica.it/index2.php?show=R41Y2019N02A010
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http://dx.doi.org/10.23736/S0031-0808.18.03533-4DOI Listing
June 2019
1 Read
2.276 Impact Factor

Usefulness of mannitol challenge testing for diagnosing asthma in everyday clinical practice.

J Asthma 2019 Apr 16:1-7. Epub 2019 Apr 16.

a Respiratory Research Unit, Department of Respiratory Medicine , Hvidovre Hospital , Hvidovre , Denmark.

Background: The mannitol test is widely used for assessment of airway responsiveness in patients with possible asthma, but our knowledge of the value in everyday clinical practice is limited.

Objective: To investigate the diagnostic value of the mannitol test in a clinical setting.

Methods: All patients having a mannitol challenge test as part of their diagnostic work-up for asthma at the respiratory outpatient clinic, Hvidovre Hospital, over a 5-year period were included in the present analysis. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2019.1
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http://dx.doi.org/10.1080/02770903.2019.1600144DOI Listing
April 2019
1 Read

Identification of Novel Circulating MicroRNA Biomarkers for the Diagnosis of Esophageal Squamous Cell Carcinoma and Squamous Dysplasia.

Cancer Epidemiol Biomarkers Prev 2019 Apr 15. Epub 2019 Apr 15.

Epidemiology and Health Statistics, Capital Medical University

Background: Circulating microRNAs (miRNAs) have been identified as diagnostic biomarkers for esophageal squamous cell carcinoma (ESCC), but their efficacy in discovering early-stage ESCC is still unsatisfying. Esophageal squamous dysplasia (ESD) is the precursor lesion of ESCC. Notably, little is known about the role(s) of circulating miRNAs in identifying ESD. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1199DOI Listing

Trisomy 21 in both fetuses in a DCDA twin pregnancy.

BMJ Case Rep 2019 Apr 14;12(4). Epub 2019 Apr 14.

Obstetrics and Gynecology, National University Hospital, Singapore.

A woman's chances of having a child with Down syndrome increases with age. By age 40, the risk of conceiving a child with Down syndrome is about 1 in 100. We report a rare case of dizygotic dichorionic diamniotic twin pregnancy conceived via in vitro fertilisation, with both twins having trisomy 21. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22760
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http://dx.doi.org/10.1136/bcr-2018-227608DOI Listing
April 2019
2 Reads

Consensus on the prevention, diagnosis, and treatment of Clostridium difficile infection.

Rev Gastroenterol Mex 2019 Apr 12. Epub 2019 Apr 12.

Hospital Ángeles y Hospital Lomas, San Luis Potosí, S.L.P., México. Electronic address:

In recent decades, Clostridium difficile infection (CDI) has become a worldwide health problem. Mexico is no exception, and therefore the Asociación Mexicana de Gastroenterología brought together a multidisciplinary group (gastroenterologists, endoscopists, internists, infectious disease specialists, and microbiologists) to carry out the "Consensus on the prevention, diagnosis, and treatment of Clostridium difficile infection", establishing useful recommendations (in relation to the adult population) for the medical community. Said recommendations are presented herein. Read More

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http://dx.doi.org/10.1016/j.rgmx.2018.12.001DOI Listing
April 2019
1 Read

A Validation Study of the Chinese Version of the Mini-Addenbrooke's Cognitive Examination for Screening Mild Cognitive Impairment and Mild Dementia.

J Geriatr Psychiatry Neurol 2019 Apr 15:891988719841726. Epub 2019 Apr 15.

1 Department of Neurology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.

Background/aims: There are limited cognitive screening tests for the Chinese-speaking population. This study aimed to validate the Chinese version of the Mini-Addenbrooke's Cognitive Examination (M-ACE) for detecting mild cognitive impairment (MCI) and mild dementia. Its diagnostic accuracy was compared with that of Mini-Mental State Examination (MMSE). Read More

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http://dx.doi.org/10.1177/0891988719841726DOI Listing

Development and evaluation of a tablet-based diagnostic audiometer.

Int J Audiol 2019 Apr 15:1-8. Epub 2019 Apr 15.

a Department of Electrical & Computer Engineering , Aristotle University of Thessaloniki , Thessaloniki , Greece.

Objective: To develop and evaluate a software application capable of conducting Pure-Tone Audiometry tests in clinical practice.

Design: We designed and developed a mobile software application for iPad devices that performs Pure-Tone Audiometry according to ANSI and IEC standards. The application is proposed to be operated by a trained audiologist inside a sound booth. Read More

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https://www.tandfonline.com/doi/full/10.1080/14992027.2019.1
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http://dx.doi.org/10.1080/14992027.2019.1600204DOI Listing
April 2019
1 Read

The Basics and the Advancements in Diagnosis of Bacterial Lower Respiratory Tract Infections.

Diagnostics (Basel) 2019 Apr 3;9(2). Epub 2019 Apr 3.

Motif BioSciences, Princeton, NJ 08540, USA.

Lower respiratory tract infections (LRTIs) are the leading infectious cause of death and the sixth-leading cause of death overall worldwide. , with more than 90 serotypes, remains the most common identified cause of community-acquired acute bacterial pneumonia. Antibiotics treat LRTIs with a bacterial etiology. Read More

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https://www.mdpi.com/2075-4418/9/2/37
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http://dx.doi.org/10.3390/diagnostics9020037DOI Listing
April 2019
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Prediction Medicine: Biomarkers, Risk Calculators and Magnetic Resonance Imaging as Risk Stratification Tools in Prostate Cancer Diagnosis.

Int J Mol Sci 2019 Apr 2;20(7). Epub 2019 Apr 2.

Department of Radiology & Nuclear Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.

This review discusses the most recent evidence for currently available risk stratification tools in the detection of clinically significant prostate cancer (csPCa), and evaluates diagnostic strategies that combine these tools. Novel blood biomarkers, such as the Prostate Health Index (PHI) and 4Kscore, show similar ability to predict csPCa. Prostate cancer antigen 3 (PCA3) is a urinary biomarker that has inferior prediction of csPCa compared to PHI, but may be combined with other markers like TMPRSS2-ERG to improve its performance. Read More

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http://dx.doi.org/10.3390/ijms20071637DOI Listing

Assessment of PD-L1 mRNA and protein expression in non-small cell lung cancer, head and neck squamous cell carcinoma and urothelial carcinoma tissue specimens using RNAScope and immunohistochemistry.

PLoS One 2019 15;14(4):e0215393. Epub 2019 Apr 15.

Precision Medicine Laboratories, Precision Medicine and Genomics, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, United Kingdom.

Four immunohistochemistry (IHC) diagnostic assays have been approved for tumour PD-L1 protein assessment in the clinic. However, mRNA detection by in situ hybridisation (ISH) could be utilised as an alternative to protein detection. Detecting spatial changes in gene expression provides vital prognostic and diagnostic information, particularly in immune oncology where the phenotype, cellular infiltration and immune activity status may be associated with patient survival. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215393PLOS

Pneumothorax: A Rare Entity During Pregnancy.

Turk Thorac J 2019 Apr 9. Epub 2019 Apr 9.

Department of Thoracic Surgery, Ege University, School of Medicine, İzmir, Turkey.

Pneumothorax is a rarely seen condition during pregnancy, when changes in the respiratory physiology can sensitize the mother and fetus to the signs of hypoxia. Symptoms of pneumothorax, such as dyspnea, tachypnea, and chest pain, can also be attributed to pregnancy and complications with pregnancy and this can lead to misdiagnoses. The limitations in the use of diagnostic tests, such as chest X-ray and computed tomography, make treatment more difficult. Read More

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http://turkthoracj.org/eng/makale/1108/154/Full-Text
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http://dx.doi.org/10.5152/TurkThoracJ.2018.18154DOI Listing
April 2019
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Is psychopathology elevated in Big-C visual artists and scientists?

J Abnorm Psychol 2019 Apr 15. Epub 2019 Apr 15.

Jane and Terry Semel Institute of Neuroscience and Human Behavior.

The idea that psychopathology is associated with exceptional creativity has persisted despite a paucity of corroborating or disconfirming evidence. The authors measured psychopathology, including schizotypal personality traits, social responsiveness/autism spectrum traits, and lifetime incidence of mental disorders, along with lab-based tests of creativity in a unique sample of (exceptionally creative) individuals. The authors examined Big-C visual artists (VIS; = 35), Big-C scientists (SCI; = 41), and a smart comparison group (SCG; n = 31) matched on age, sex, race/ethnicity, parental education, and estimated IQ. Read More

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http://doi.apa.org/getdoi.cfm?doi=10.1037/abn0000416
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http://dx.doi.org/10.1037/abn0000416DOI Listing
April 2019
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Recent Laboratory Advances in Diagnostics and Monitoring Response to Treatment in Leprosy.

Authors:
Utpal Sengupta

Indian Dermatol Online J 2019 Mar-Apr;10(2):106-114

Departemnt of Microbiology and Immunology, Stanley Browne Laboratory, TLM Community Hospital, Nand Nagri, New Delhi, India.

The present review briefly summarizes the highlights of the recent advances in -specific tests for early diagnosis of leprosy. In addition to establishing the diagnosis of clinical cases of leprosy, these tests have also been used to detect subclinical infections in endemic population. Several attempts have been made from 1980 onward for standardization of specific diagnostic assays for early detection of leprosy. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_260_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434766PMC
April 2019
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Comparison of the Accuracy of Four Malaria Diagnostic Methods in a High Transmission Setting in Coastal Cameroon.

J Parasitol Res 2019 10;2019:1417967. Epub 2019 Mar 10.

The Biotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon.

Background: Despite recommendation from the World Health Organization that all malaria suspected patients undergo a parasitological confirmation using rapid diagnostic test or light microscopy prior to treatment, health facilities in remote malaria endemic settings sometimes resort to presumptive diagnosis of malaria for clinical management for various reasons. Following observation of this practice, we undertook a cross-sectional study aimed at comparing presumptive diagnosis based on axillary temperature, SD Bioline™ rapid test, and light microscopy as strategies for malaria diagnosis in the coastal region of Mutengene in the South West of Cameroon with the overall goal of supporting improved malaria diagnosis at local levels.

Methodology: Venous blood from 320 participants was used to detect the presence of malaria parasite using SD Bioline™ mRDT and Giemsa stained microscopy or spotted on filter paper for PCR amplification of the 18s rRNA gene of following standard procedures. Read More

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http://dx.doi.org/10.1155/2019/1417967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431520PMC

A Practical Review of Cytomegalovirus in Gastroenterology and Hepatology.

Gastroenterol Res Pract 2019 7;2019:6156581. Epub 2019 Mar 7.

Division of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, CA, USA.

Human cytomegalovirus (CMV) is a ubiquitous virus with a wide spectrum of pathology in humans. Host immunity is a major determinant of the clinical manifestation of CMV and can vary widely in the gastroenterology and hepatology practice setting. Immunocompetent patients generally develop a benign, self-limited mononucleosis-like syndrome whereas gastrointestinal tissue-invasive disease is more frequently seen in immunocompromised and inflammatory bowel disease patients. Read More

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https://www.hindawi.com/journals/grp/2019/6156581/
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http://dx.doi.org/10.1155/2019/6156581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431500PMC
March 2019
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Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management.

Front Immunol 2019 26;10:586. Epub 2019 Mar 26.

Hospital U. Vall d'Hebron, Barcelona, Spain.

Immunodeficiencies (ID), in particular primary immunodeficiencies (PID), are often associated with haematological manifestations, such as peripheral cytopenias or lymphoproliferative syndromes. Early diagnosis and management have significant prognostic implications. Secondary immunodeficiencies (SID) may also be induced by oncohaematological diseases and their treatments. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448689PMC

A Clinicopathological and Immunofluorescence Study of Intraepidermal Immunobullous Diseases.

Indian J Dermatol 2019 Mar-Apr;64(2):101-105

Departments of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Context: Autoimmune blistering diseases (AIBDs) are characterized by autoantibodies directed against antigens of skin. Direct immunofluorescence (DIF) study helps in confirming the diagnosis where histopathology alone is noncontributory.

Aims: This study aimed to evaluate the clinicopathological and DIF features of intraepidermal AIBD and to assess their relative diagnostic significance. Read More

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http://dx.doi.org/10.4103/ijd.IJD_515_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440185PMC
April 2019
2 Reads

Early onset food protein-induced enterocolitis syndrome in two breastfed newborns masquerading as surgical diseases: case reports and literature review.

J Matern Fetal Neonatal Med 2019 Apr 14:1-131. Epub 2019 Apr 14.

d Neonatal Intensive Care Unit , Ca' Foncello Hospital , Treviso , Italy.

Background: Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE cell-mediated gastrointestinal food allergy that primarily presents in infancy, as early as the first hours of life. FPIES is often misdiagnosed as sepsis, severe gastroenteritis, abdominal surgical emergency or even metabolic, neurologic or cardiac disorders.

Methods: We report two neonatal cases of cow's milk protein (CMP)-induced FPIES masquerading as surgical diseases. Read More

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http://dx.doi.org/10.1080/14767058.2019.1608435DOI Listing
April 2019
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Perspectives in veterinary medicine: Description and classification of bronchiolar disorders in cats.

J Vet Intern Med 2019 Apr 13. Epub 2019 Apr 13.

Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.

This Perspectives in Veterinary Medicine article seeks to define, describe putative causes, and discuss key diagnostic tests for primary and secondary bronchiolar disorders to propose a classification scheme in cats with support from a literature review and case examples. The small airways (bronchioles with inner diameters <2 mm), located at the transitional zone between larger conducting airways and the pulmonary acinus, have been overlooked as major contributors to clinical syndromes of respiratory disease in cats. Because the trigger for many bronchiolar disorders is environmental and humans live in a shared environment with similar susceptibility, understanding these diseases in pet cats has relevance to One Health. Read More

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http://dx.doi.org/10.1111/jvim.15473DOI Listing

Differences between palpation and static/dynamic tests to diagnose painful temporomandibular disorders in patients with Lyme disease.

Clin Oral Investig 2019 Apr 13. Epub 2019 Apr 13.

Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objectives: The aim was to determine the frequency of Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD)-based pain diagnoses and dynamic/static tests-based pain diagnoses, and to assess the agreement of palpation tests with static/dynamic tests.

Materials And Methods: Eighty-six (N = 86) adult patients with Lyme disease (mean age 57.0 ± 14. Read More

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http://dx.doi.org/10.1007/s00784-019-02890-4DOI Listing

Evaluation of three consecutive versions of a commercial rapid PCR test to screen for methicilin-resistant Staphylococcus aureus.

Clin Microbiol Infect 2019 Apr 10. Epub 2019 Apr 10.

Service of hospital preventive medicine, Lausanne University Hospital, Lausanne, Switzerland; Swiss National Reference Centre for Emerging Antibiotic Resistance (NARA), Fribourg, Switzerland. Electronic address:

Objectives: Screening for Methicillin-resistant Staphylococcus aureus (MRSA) is part of many recommendations to control MRSA. Several rapid PCR tests are available commercially and updated versions are constantly released. We aimed to evaluate the performance of three consecutive versions (G3, Gen3 and NxG) of the XpertMRSA test. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.03.029DOI Listing