180,302 results match your criteria Screening and Diagnostic Tests


Outcomes of second opinions in general internal medicine.

PLoS One 2020 9;15(7):e0236048. Epub 2020 Jul 9.

Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: To date, the outcomes of second opinions in internal medicine in terms of diagnostic yield and patient benefit have not been studied extensively. This retrospective study explores the outcomes of second opinions at a general internal medicine outpatient clinic in an academic hospital.

Methods: A register of all patients referred to the general internal medicine outpatient clinic of the University Medical Center in Utrecht for a second opinion, was kept. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236048PLOS

A spatio-temporal approach to short-term prediction of visceral leishmaniasis diagnoses in India.

PLoS Negl Trop Dis 2020 Jul 9;14(7):e0008422. Epub 2020 Jul 9.

Centre for Mathematical Modelling of Infectious Disease and Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Background: The elimination programme for visceral leishmaniasis (VL) in India has seen great progress, with total cases decreasing by over 80% since 2010 and many blocks now reporting zero cases from year to year. Prompt diagnosis and treatment is critical to continue progress and avoid epidemics in the increasingly susceptible population. Short-term forecasts could be used to highlight anomalies in incidence and support health service logistics. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008422DOI Listing

Rhabdomyolysis, Methamphetamine, Amphetamine and MDMA Use: Associated Factors and Risks.

J Dual Diagn 2020 Jul 9:1-9. Epub 2020 Jul 9.

Department of Emergency Medicine, Davis Medical Center, University of California, Sacramento, CA, USA.

Objective: Rhabdomyolysis is associated with methamphetamine, amphetamine, and methylenedioxymethamphetamine (MA) use. The aim of this study was to determine the frequency, severity, and risk factors of rhabdomyolysis associated with MA use. We reviewed patients with an MA-positive toxicology screen with and without diagnosed rhabdomyolysis based on initial creatine kinase (CK) concentration over a period of 6 years. Read More

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http://dx.doi.org/10.1080/15504263.2020.1786617DOI Listing

Considering histamine in functional gastrointestinal disorders.

Crit Rev Food Sci Nutr 2020 Jul 9:1-8. Epub 2020 Jul 9.

Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria.

In westernized countries, adverse reactions to ingested foods are reported to affect up to 20% of the population. Functional, nonspecific, non-allergic gastrointestinal complaints are mainly due to the intolerance/malabsorption of carbohydrates (lactose and fructose), proteins (gluten), and biogenic amines (histamine). Food intolerance/malabsorption is defined by one or several of the above mentioned food components not being degraded and/or absorbed properly within the gastrointestinal tract. Read More

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http://dx.doi.org/10.1080/10408398.2020.1791049DOI Listing

Mechanistic insights into antiretroviral drug-induced liver injury.

Pharmacol Res Perspect 2020 Aug;8(4):e00598

Division of Chemical and System Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

All classes of antiretroviral therapy (ART) have been implicated to induce adverse drug reactions such drug-induced liver injury (DILI) and immune-mediated adverse reactions in Human Immunodeficiency Virus (HIV) infected individuals. Patients that develop adverse drug reactions tend to have prolonged stays in hospital and may require to change to alternative regimens if reactions persist upon rechallenge or if rechallenge is contraindicated due to severity of the adverse reaction. Diagnosis of DILI remains a huge obstacle that delays timely interventions, since it is still based largely on exclusion of other causes. Read More

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http://dx.doi.org/10.1002/prp2.598DOI Listing

Late-onset acute liver failure due to Wilson's disease managed by plasmapheresis and hemodiafiltration successfully serving as a bridge for deceased donor liver transplantation: a case report and literature review.

Clin J Gastroenterol 2020 Jul 8. Epub 2020 Jul 8.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Late-onset acute liver failure due to Wilson's disease (WD-ALF) is rare. A 44-year-old female patient presenting acute hepatic decompensation with extreme coagulopathy was transferred to our hospital for evaluation for liver transplantation (LT). Alveolar hemorrhage and Coombs-negative acute hemolysis occurred during workup. Read More

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http://dx.doi.org/10.1007/s12328-020-01175-8DOI Listing

COVID-19: Current Trends in Invitro Diagnostics.

Indian J Clin Biochem 2020 Jul 27;35(3):285-289. Epub 2020 Jun 27.

R&D Reagent Department, Agappe Diagnostics Limited, Cochin, Kerala India.

The novel coronavirus SARS-CoV-2 is the seventh known species of coronavirus, infectious to human beings. The pandemic COVID-19 spread all over the world with an unprecedented spreading rate after its first appearance in Wuhan, China. As a novel viral disease there in no antiviral treatment or vaccine for the COVID-19. Read More

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http://dx.doi.org/10.1007/s12291-020-00906-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320251PMC

Impact of Acarbose on Incident Diabetes and Regression to Normoglycemia in People With Coronary Heart Disease and Impaired Glucose Tolerance: Insights From the ACE Trial.

Diabetes Care 2020 Jul 8. Epub 2020 Jul 8.

Diabetes Trials Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.

Objective: We examined the impact of acarbose, an α-glucosidase inhibitor, on incident diabetes and regression to normoglycemia in 6,522 Acarbose Cardiovascular Evaluation trial participants in China who had impaired glucose tolerance (IGT) and coronary heart disease (CHD).

Research Design And Methods: Participants were randomly assigned to acarbose or placebo and followed with four monthly fasting plasma glucose (FPG) tests and annual oral glucose tolerance tests. Incident diabetes was defined as two successive diagnostic FPG levels ≥7 mmol/L or 2-h plasma glucose (PG) levels ≥11. Read More

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http://dx.doi.org/10.2337/dc19-2046DOI Listing

Validating injury-related diagnoses by physicians: an analysis of 62,269 hospitalizations from a large hospital in Changsha, China.

Injury 2020 Jul 3. Epub 2020 Jul 3.

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, 410078, China. Electronic address:

Objective: To assess the accuracy of injury-related hospitalization diagnoses by physicians in China.

Methods: 62,269 hospitalizations between 2014 and 2016 at a large hospital in Changsha, China were assessed. We considered three types of diagnostic errors: under-reporting, lack of cause specificity, and misclassification across injury causes. Read More

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http://dx.doi.org/10.1016/j.injury.2020.07.004DOI Listing

Diagnostic Performance of Prehospital Point-of-Care Troponin Tests to Rule Out Acute Myocardial Infarction: A Systematic Review.

Prehosp Disaster Med 2020 Jul 9:1-7. Epub 2020 Jul 9.

Division of Cardiovascular Sciences, University of Manchester, Manchester, UK.

Introduction: Chest pain is one of the most common reasons for 999 calls and transfers to the emergency department (ED). In these patients, acute myocardial infarction (AMI) is often the diagnosis that clinicians are seeking to exclude. However, only a minority of those patients have AMI, causing a substantial financial burden to health services. Read More

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http://dx.doi.org/10.1017/S1049023X20000850DOI Listing

Evaluating the implementation of rapid diagnostic tests in a malaria elimination setting.

Infect Dis Poverty 2020 Jul 8;9(1):84. Epub 2020 Jul 8.

Key Lab of Health Technology Assessment, National Health Committee, Shanghai, China.

Background: It was recommended that malaria rapid diagnostic tests (RDTs) should be available in all epidemiological situations. But evidence was limited on the implementation of RDTs and its effectiveness in malaria elimination settings. This study examined the implementation of RDTs and how it affected the diagnosis of imported malaria patients in Jiangsu Province, China. Read More

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http://dx.doi.org/10.1186/s40249-020-00702-6DOI Listing

Improving Timeliness of Lung Cancer Diagnosis and Staging Investigations Through Implementation of Standardized Triage Pathways.

JCO Oncol Pract 2020 Jul 8:JOP1900807. Epub 2020 Jul 8.

Queen's University, Kingston, Ontario, Canada.

Purpose: Timely care for patients with lung cancer (LC) is associated with improved clinical outcomes. In Southeastern Ontario, Canada, we identified delays in the diagnostic process for patients undergoing evaluation for suspected LC through a rapid assessment clinic. We developed improvement initiatives with an aim of reducing the time from referral to diagnosis. Read More

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http://dx.doi.org/10.1200/JOP.19.00807DOI Listing

Correlates of the Abnormal Involuntary Movement Scale in Veterans With Tardive Dyskinesia.

J Clin Psychopharmacol 2020 Jul/Aug;40(4):373-380

From the Behavioral Health Service, Corporal Michael J. Crescenz VA Medical Center.

Purpose/background: To add to limited evidence on the Abnormal Involuntary Movement Scale (AIMS) as a measure of tardive dyskinesia (TD) in clinical practice settings, the characteristics and correlates of AIMS scores were assessed.

Methods/procedures: Veterans with schizophrenia/schizoaffective, bipolar, or major depressive disorders receiving antipsychotics and at least 1 AIMS score during October 1, 2014, to September 30, 2015, were identified. Tardive dyskinesia was determined by the International Classification of Diseases, Ninth Revision, Clinical Modification, codes. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001229DOI Listing

PD-1 mRNA expression in peripheral blood mononuclear cells as a biomarker for different stages of primary gouty arthritis.

J Cell Mol Med 2020 Jul 8. Epub 2020 Jul 8.

Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

There is currently a lack of biomarkers to assist the diagnosis and prediction of primary gouty arthritis (PG). Therefore, we evaluated the clinical value of programmed cell death protein 1 (PD-1) mRNA expression in peripheral blood mononuclear cells (PBMCs) of patients with PG. This study included 36 patients with acute phase PG (APPG), 48 with non-acute phase PG (NAPPG), 42 with asymptomatic hyperuricemia (AH) and 79 normal controls (NCs). Read More

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http://dx.doi.org/10.1111/jcmm.15582DOI Listing

Improving the coverage and accuracy of syphilis testing: The development of a novel rapid, point-of-care test for confirmatory testing of active syphilis infection and its early evaluation in China and South Africa.

EClinicalMedicine 2020 Jul 27;24:100440. Epub 2020 Jun 27.

Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia.

Background: Current point-of-care tests (POCT) for syphilis, based on the detection of (TP) total antibodies, have limited capacity in distinguishing between active and past/treated syphilis. We report the development and early evaluation of a new prototype POCT based on the detection of TP-IgA antibodies, a novel biomarker for active syphilis.

Methods: The TP-IgA POCT (index test) was developed in response to the World Health Organisation (WHO) target product profile (TPP) for a POCT for confirmatory syphilis testing. Read More

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http://dx.doi.org/10.1016/j.eclinm.2020.100440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327895PMC

Acute progressing hepatic angiosarcoma: An autopsy case report.

Radiol Case Rep 2020 Aug 29;15(8):1403-1407. Epub 2020 Jun 29.

Department of Gastroenterology and Hepatology, Graduate school of Medicine, Hokkaido University, kita 14-jo nishi 5-chome kita-ku, Sapporo 060-8648, Japan.

A man in his 50s presented with pitting edema of both lower legs and abdominal distension as his chief complaint. His personal medical history and family history were unremarkable, except that he was a heavy drinker consuming 66 g of alcohol per day and a heavy smoker. Blood tests upon admission showed slight hepatic dysfunction, thrombocytopenia, jaundice, hypoalbuminemia, and decreased coagulability. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329938PMC

Laboratory Tests for COVID-19: A Review of Peer-Reviewed Publications and Implications for Clinical UIse.

Mo Med 2020 May-Jun;117(3):184-195

MSMA member since 2019 and Missouri Medicine Editorial Board Member for Infectious Disease, Divisions of Infectious Diseases, Pulmonary, Critical Care and Environmental Medicine, University of Missouri - Columbia, Columbia, Missouri.

Diagnostic tests for the coronavirus infection 2019 (COVID-19) are critical for prompt diagnosis, treatment and isolation to break the cycle of transmission. A positive real-time reverse-transcriptase polymerase chain reaction (RT-PCR), in conjunction with clinical and epidemiologic data, is the current standard for diagnosis, but several challenges still exist. Serological assays help to understand epidemiology better and to evaluate vaccine responses but they are unreliable for diagnosis in the acute phase of illness or assuming protective immunity. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302033PMC

Impairment of intermediate somatosensory function in corticobasal syndrome.

Sci Rep 2020 Jul 7;10(1):11155. Epub 2020 Jul 7.

Department of Neurology, Mie University Graduate School of Medicine, Tsu, Japan.

Corticobasal syndrome (CBS) is characterized by unilateral atrophy of the brain. New diagnostic criteria for CBS include intermediate somatosensory dysfunction. Here, we aimed to carefully examine intermediate somatosensory function to identify tests which can assess impairment in CBS patients. Read More

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http://dx.doi.org/10.1038/s41598-020-67991-7DOI Listing

Clinical evaluation of self-collected saliva by RT-qPCR, direct RT-qPCR, RT-LAMP, and a rapid antigen test to diagnose COVID-19.

J Clin Microbiol 2020 Jul 7. Epub 2020 Jul 7.

Department of Infectious Diseases, International University of Health and Welfare Narita Hospital, Chiba, Japan.

The clinical performance of six molecular diagnostic tests and a rapid antigen test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were clinically evaluated for the diagnosis of coronavirus disease 2019 (COVID-19) in self-collected saliva. Saliva samples from 103 patients with laboratory-confirmed COVID-19 (15 asymptomatic and 88 symptomatic) were collected on the day of hospital admission. SARS-CoV-2 RNA in saliva was detected using a quantitative reverse-transcription polymerase chain reaction (RT-qPCR) laboratory-developed test (LDT), a cobas SARS-CoV-2 high-throughput system, three direct RT-qPCR kits, and reverse-transcription loop mediated isothermal amplification (RT-LAMP). Read More

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http://dx.doi.org/10.1128/JCM.01438-20DOI Listing

External validation of stroke mimic prediction scales in the emergency department.

BMC Neurol 2020 Jul 7;20(1):269. Epub 2020 Jul 7.

Accident and Emergency Department, Changi General Hospital, Singapore, Singapore.

Background: Acute ischemic stroke is a time-sensitive emergency where accurate diagnosis is required promptly. Due to time pressures, stroke mimics who present with similar signs and symptoms as acute ischemic stroke, pose a diagnostic challenge to the emergency physician. With limited access to investigative tools, clinical prediction, tools based only on clinical features, may be useful to identify stroke mimics. Read More

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http://dx.doi.org/10.1186/s12883-020-01846-6DOI Listing

Enhancing colorimetric loop-mediated isothermal amplification speed and sensitivity with guanidine chloride.

Biotechniques 2020 Jul 8. Epub 2020 Jul 8.

New England Biolabs, Inc. 240 County Road, Ipswich, MA 01938, USA.

Loop-mediated isothermal amplification (LAMP) is a versatile technique for detection of target DNA and RNA, enabling rapid molecular diagnostic assays with minimal equipment. The global SARS-CoV-2 pandemic has presented an urgent need for new and better diagnostic methods, with colorimetric LAMP utilized in numerous studies for SARS-CoV-2 detection. However, the sensitivity of colorimetric LAMP in early reports has been below that of the standard RT-qPCR tests, and we sought to improve performance. Read More

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http://dx.doi.org/10.2144/btn-2020-0078DOI Listing

Laboratory Assay Evaluation Demystified: A Review of Key Factors Influencing Interpretation of Test Results Using Different Assays for SARS-CoV-2 Infection Diagnosis.

Lab Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Aurora.

Laboratory tests are an integral part of the diagnosis and management of patients; however, these tests are far from perfect. Their imperfections can be due to patient health condition, specimen collection, and/or technological difficulty with performing the assay and/or interpretation. To be useful clinically, testing requires calculation of positive predictive values (PPVs) and negative predictive values (NPVs). Read More

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http://dx.doi.org/10.1093/labmed/lmaa045DOI Listing

Sensitivity and specificity of malaria rapid diagnostic test (mRDT CareStatTM) compared with microscopy amongst under five children attending a primary care clinic in southern Nigeria.

Afr J Prim Health Care Fam Med 2020 Jun 17;12(1):e1-e8. Epub 2020 Jun 17.

Lincoln University College, Selangor.

Background: Malaria diagnosis using microscopy is currently the gold standard. However, malaria rapid diagnostic tests (mRDTs) were developed to simplify the diagnosis in regions without access to functional microscopy.

Aim: The objective of this study was to compare the diagnostic accuracy of mRDT CareStatTM with microscopy. Read More

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http://dx.doi.org/10.4102/phcfm.v12i1.2212DOI Listing

The Patterns and Associated Cost of Serologic Testing for Helicobacter pylori in the U.S. Military Health System.

Mil Med 2020 Jul 7. Epub 2020 Jul 7.

Gastroenterology Service, Department of Internal Medicine, WRNMMC, Department of Medicine, Uniformed Services University of the Health Sciences, 8901 Rockville Pike, Bethesda, MD 20889.

Introduction: Helicobacter pylori (H. pylori) infection affects about half of the world's population and can lead to multiple complications if left untreated. Testing for H. Read More

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http://dx.doi.org/10.1093/milmed/usaa141DOI Listing

Laboratory Diagnosis of Leptospirosis.

Authors:
Nobuo Koizumi

Methods Mol Biol 2020 ;2134:277-287

Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.

The diagnosis of leptospirosis depends on specific laboratory tests because nonspecific and diverse clinical manifestations make clinical diagnosis difficult and it is easily confused with other infectious diseases in the tropics. Suitable laboratory diagnostic tests vary depending on the stage of the disease, requiring the combination of diagnostic tests using appropriate specimens at each disease stage. Read More

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http://dx.doi.org/10.1007/978-1-0716-0459-5_25DOI Listing
January 2020

Current status of development of methylation biomarkers for in vitro diagnostic IVD applications.

Clin Epigenetics 2020 Jul 6;12(1):100. Epub 2020 Jul 6.

Independent Clinical Epigenetics Laboratory, Pomeranian Medical University, Unii Lubelskiej 1, 71-252, Szczecin, Poland.

A significant volume of research clearly shows that disease-related methylation changes can be used as biomarkers at all stages of clinical disease management, including risk assessment and predisposition screening through early diagnostics to personalization of patient care and monitoring of the relapse and chronic disease. Thus disease-related methylation changes are an attractive source of the biomarkers that can have significant impact on precision medicine. However, the translation of the research findings in methylation biomarkers field to clinical practice is at the very least not satisfactory. Read More

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http://dx.doi.org/10.1186/s13148-020-00886-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336678PMC

Defining symptoms of malaria in India in an era of asymptomatic infections.

Malar J 2020 Jul 6;19(1):237. Epub 2020 Jul 6.

Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY, 10003, USA.

Background: Malaria is a major public health problem in India. Data from surveys totaling 3031 participants at three sites revealed a high proportion of asymptomatic infections, complicating diagnosis. The aim of this study was to identify differences in complaints and symptoms between sites, and factors associated with asymptomatic Plasmodium infections. Read More

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http://dx.doi.org/10.1186/s12936-020-03310-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339403PMC

Alterations in Serum-Free Amino Acid Profiles in Childhood Asthma.

Int J Environ Res Public Health 2020 Jul 2;17(13). Epub 2020 Jul 2.

Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 60 -780 Poznan, Poland.

Asthma often begins in childhood, although making an early diagnosis is difficult. Clinical manifestations, the exclusion of other causes of bronchial obstruction, and responsiveness to anti-inflammatory therapy are the main tool of diagnosis. However, novel, precise, and functional biochemical markers are needed in the differentiation of asthma phenotypes, endotypes, and creating personalized therapy. Read More

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http://dx.doi.org/10.3390/ijerph17134758DOI Listing

Development and Evaluation of a duo SARS-CoV-2 RT-qPCR Assay Combining Two Assays Approved by the World Health Organization Targeting the Envelope and the RNA-Dependant RNA Polymerase (RdRp) Coding Regions.

Viruses 2020 06 25;12(6). Epub 2020 Jun 25.

Unité des Virus Émergents (UVE: Aix-Marseille Univ-IRD 190-Inserm 1207-IHU Méditerranée Infection), 13005 Marseille, France.

The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide has highlighted the importance of reliable and rapid diagnostic testing to prevent and control virus circulation. Dozens of monoplex in-house RT-qPCR assays are already available; however, the development of dual-target assays is suited to avoid false-negative results caused by polymorphisms or point mutations, that can compromise the accuracy of diagnostic and screening tests. In this study, two mono-target assays recommended by WHO (E-Sarbeco (enveloppe gene, Charite University, Berlin, Germany) and RdRp-IP4 (RdRp, Institut Pasteur, Paris, France)) were selected and combined in a unique robust test; the resulting duo SARS-CoV-2 RT-qPCR assay was compared to the two parental monoplex tests. Read More

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http://dx.doi.org/10.3390/v12060686DOI Listing

New Biomarkers in Acute Tubulointerstitial Nephritis: A Novel Approach to a Classic Condition.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Bellvitge University Hospital, Nephrology Department, 08907 Hospitalet de Llobregat, Barcelona, Spain.

Acute tubulointerstitial nephritis (ATIN) is an immunomediated cause of acute kidney injury. The prevalence of ATIN among the causes of acute kidney injury (AKI) is not negligible, especially those cases related to certain drugs. To date, there is a lack of reliable non-invasive diagnostic and follow-up markers. Read More

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http://dx.doi.org/10.3390/ijms21134690DOI Listing

Diagnostic Potential of IgG and IgA Responses to t Antigens for Discrimination among Active Tuberculosis, Latent Tuberculosis Infection, and Non-Infected Individuals.

Microorganisms 2020 Jun 30;8(7). Epub 2020 Jun 30.

Department of Biomedical Sciences, Microbiology and Immunology and Liver Research Institute, College of Medicine, Seoul National University, Seoul 03080, Korea.

Tuberculosis remains a major public health problem. Conventional tests are inadequate to distinguish between active tuberculosis (ATB) and latent tuberculosis infection (LTBI). We measured antibody responses to antigens ( chorismate mutase (TBCM), antigen 85B (Ag85B), early secreted antigen-6 (ESAT-6), and culture filtrate protein-10 (CFP-10) in ATB, LTBI, and non-infected (NI) individuals. Read More

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http://dx.doi.org/10.3390/microorganisms8070979DOI Listing

Diagnostic performance of artificial intelligence to detect genetic diseases with facial phenotypes: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2020 Jul;99(27):e20989

College of Information Science and Electronic Engineering.

Background: Many genetic diseases are known to have distinctive facial phenotypes, which are highly informative to provide an opportunity for automated detection. However, the diagnostic performance of artificial intelligence to identify genetic diseases with facial phenotypes requires further investigation. The objectives of this systematic review and meta-analysis are to evaluate the diagnostic accuracy of artificial intelligence to identify the genetic diseases with face phenotypes and then find the best algorithm. Read More

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http://dx.doi.org/10.1097/MD.0000000000020989DOI Listing

Characterization of circulating myeloma tumor cells by next generation flowcytometry in scleromyxedema patient: a case report.

Medicine (Baltimore) 2020 Jul;99(27):e20726

Hamad Medical Corporation, Hematology and Medical Oncology Department.

Introduction: Scleromyxedema (rare cutaneous mucinosis), is characterized by the formation of lichenoid papules and presence of Serum monoclonal IgG in most cases, or all; after repeated testing.

Patient Concerns: The patient is a 51-year-old male presented with thick, disfiguring elephant-like erythematous skin folds over the forehead, papular shiny eruptions over ears and trunk and waxy erythematous papules over arms and hands without dysphagia or respiratory or neurologic symptoms DIAGNOSIS: : Skin biopsy from right arm was consistent with scleromyxedema. Serum cryoglobulin was reported negative. Read More

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http://dx.doi.org/10.1097/MD.0000000000020726DOI Listing

Commentary on Perinatal Peril: Diagnosis of HIV in a Newborn.

Clin Chem 2020 Jul;66(7):881-882

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC.

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http://dx.doi.org/10.1093/clinchem/hvaa057DOI Listing

Biomarkers of pituitary macroadenomas aggressive behaviour: a conventional MRI and DWI 3T study.

Br J Radiol 2020 Jul 6:20200321. Epub 2020 Jul 6.

Department of Neuroradiology, Ospedale Bellaria, IRCCS Institute of Neurological Sciences of Bologna, Via Altura, 3; 40100 Bolgona, Italy.

Objective: Pituitary macroadenomas (PAs) are usually defined as benign intracranial tumors. However, they may present local aggressive course. High Ki67 labelling index (LI) values have been related to an aggressive tumor behavior. Read More

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http://dx.doi.org/10.1259/bjr.20200321DOI Listing

A prospective study on rapid exome sequencing as a diagnostic test for multiple congenital anomalies on fetal ultrasound.

Prenat Diagn 2020 Jul 6. Epub 2020 Jul 6.

Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.

Objective: Conventional genetic tests (QF-PCR and SNP-array) only diagnose ~40% of fetuses showing ultrasound abnormalities. Rapid Exome Sequencing (rES) may improve this diagnostic yield, but includes challenges such as uncertainties in fetal phenotyping, variant interpretation, incidental unsolicited findings and rapid turnaround times. In this study we implemented rES in prenatal care to increase diagnostic yield. Read More

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http://dx.doi.org/10.1002/pd.5781DOI Listing

The diagnosis of latent tuberculosis infection (LTBI): currently available tests, future developments, and perspectives to eliminate tuberculosis (TB).

Med Lav 2020 Jun 26;111(3):170-183. Epub 2020 Jun 26.

Dipartimento di Scienze della Salute Scuola di Scienze Mediche e Farmaceutiche Università degli Studi di Genova I.R.C.C.S. A.O.U. San Martino - I.S.T. di Genova.

Introduction: Despite great efforts, tuberculosis (TB) is still a major public health threat worldwide. For decades, TB control programs have focused almost exclusively on infectious TB active cases.  However, it is evident that this strategy alone cannot achieve TB elimination. Read More

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http://dx.doi.org/10.23749/mdl.v111i3.9983DOI Listing

Cytology and curetting diagnosis of endocervical adenocarcinoma.

J Am Soc Cytopathol 2020 Jun 5. Epub 2020 Jun 5.

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Introduction: Papanicolaou testing is effective in identifying squamous intraepithelial lesions of the cervix. Endocervical adenocarcinoma (EAC) and adenocarcinoma in situ (AIS) are far less commonly identified. Endocervical curettings (ECCs) are usually obtained after colposcopic biopsy, sample the endocervical canal, and aid in the detection of endocervical glandular lesions. Read More

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http://dx.doi.org/10.1016/j.jasc.2020.05.007DOI Listing

Management of functional dyspepsia in the year 2020. A clinical point of view.

Minerva Gastroenterol Dietol 2020 Jul 3. Epub 2020 Jul 3.

Unit of Gastroenterology, Molinette Hospital, Turin, Italy -

Dyspepsia is a disorder that refers mainly to central upper abdominal pain or discomfort. When a cause of this symptom is not identified the condition is termed functional dyspepsia (FD), that affects a large part of the general population. The relevance of FD is due to its high prevalence, but also to its chronic or intermittent course. Read More

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http://dx.doi.org/10.23736/S1121-421X.20.02732-4DOI Listing

Fine-needle aspiration biopsy for the diagnosis of bone and soft tissue lesions: a systematic review and meta-analysis.

J Am Soc Cytopathol 2020 Jun 9. Epub 2020 Jun 9.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, and Geisel School of Medicine at Dartmouth, Hanover, NH. Electronic address:

Introduction: The workup of musculoskeletal (MSK) lesions utilizes a range of diagnostic tests including incisional biopsy, core needle biopsy, and fine-needle aspiration (FNA). FNA is the most cost-effective and least invasive biopsy method, but variation in its reported diagnostic performance has constrained its use for MSK lesions. Herein, we undertake a meta-analysis to clarify the diagnostic performance of FNA for bone and soft tissue lesions. Read More

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http://dx.doi.org/10.1016/j.jasc.2020.05.012DOI Listing

Laboratory Diagnosis of Coronavirus Disease-2019 (COVID-19).

Clin Chim Acta 2020 Jul 1. Epub 2020 Jul 1.

Medical Technology School of Xuzhou Medical University, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou 221004, China; Department of Laboratory Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China. Electronic address:

The outbreak of Coronavirus Disease-2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has threatened health worldwide. As of the end of 2020, there were nearly 10 million confirmed cases and nearly 5 million deaths associated with COVID-19. Rapid and early laboratory diagnosis of COVID-19 is the main focus of treatment and control. Read More

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http://dx.doi.org/10.1016/j.cca.2020.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329657PMC

The optimal diagnostic methods for COVID-19.

Diagnosis (Berl) 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK.

As the world continues to study and understand coronavirus disease (COVID-19), existing investigations and tests have been used to try and detect the virus to slow viral transmission and its global spread. A 'gold-standard' investigation has not yet been identified for detection and monitoring. Initially, computed tomography (CT) was the mainstay investigation as it shows the disease severity and recovery, and its images change at different stages of the disease. Read More

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http://dx.doi.org/10.1515/dx-2020-0058DOI Listing

[Virus-induced opsoclonus-myoclonus syndrome during pregnancy].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(5):93-99

Almazov National Medical Research Centre, St. Petersburg, Russia.

Opsoclonus-myoclonus syndrome (OMS) is a very rare condition with various etiologies (paraneoplastic, parainfectious, toxic, idiopathic, etc.) with an autoimmune pathogenetic mechanism of development. The authors describe the case of OMS in a 41-year-old woman at 37 weeks of gestation, who developed opsoclonus, myoclonus, severe trunk ataxia, tremor and bilateral pyramidal symptoms, inability to sit, stand and walk without support. Read More

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http://dx.doi.org/10.17116/jnevro202012005193DOI Listing

Diagnostic accuracy of cognitive screening tools under different neuropsychological definitions for poststroke cognitive impairment.

Brain Behav 2020 Jul 3:e01671. Epub 2020 Jul 3.

Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Objectives: The accuracy of cognitive screening tools to detect poststroke cognitive impairment (PSCI) was investigated using various neuropsychological definitions.

Methods: Hospital-based stroke patients underwent a comprehensive neuropsychological assessment. The rate of PSCI was estimated using thresholds of 1, 1. Read More

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http://dx.doi.org/10.1002/brb3.1671DOI Listing

Fecal Occult Blood Tests in Colorectal Cancer Screening: Systematic Review and Meta-analysis of Traditional and New-generation Fecal Immunochemical Tests.

Anticancer Res 2020 Jul;40(7):3591-3604

Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland

Background/aim: Noninvasive fecal occult blood tests (FOBTs) are recommended by current guidelines for colorectal cancer (CRC) screening. Our aim was to assess the diagnostic performance of traditional guaiac-based FOBTs (gFOBT) and new-generation immunochemical FOBTs (iFOBT) in CRC screening by carrying out a systematic review and meta-analysis.

Patients And Methods: PubMed, Embase, Cochrane Library, and Web of Science were searched for eligible articles published before February 17, 2020. Read More

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http://dx.doi.org/10.21873/anticanres.14349DOI Listing

The international system for reporting serous fluid cytopathology-diagnostic categories and clinical management.

J Am Soc Cytopathol 2020 Jun 9. Epub 2020 Jun 9.

Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal; Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Electronic address:

Introduction: Effusions can develop inside serous cavities in several pathologic states, both neoplastic and non-neoplastic. They are easy to drain and can provide useful diagnostic information. However, the reported diagnostic efficacy of these specimens has not been uniform across different laboratories. Read More

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http://dx.doi.org/10.1016/j.jasc.2020.05.015DOI Listing

Sensitivity of a sequential model based on a questionnaire (STOP-Bang vs Dixon) and nocturnal pulse oximetry for screening obstructive sleep apnea in patients with morbid obesity candidates for bariatric surgery.

Endocrinol Diabetes Nutr 2020 Jun 30. Epub 2020 Jun 30.

Unidad de Investigación Traslacional, Hospital Miguel Servet, IIS Aragón y CIBERES Enfermedades Respiratorias, Madrid, España; Departamento de Medicina, Universidad de Zaragoza, Zaragoza, España.

Introduction: Obstructive sleep apnea (OSA) has a high incidence in patients with morbid obesity who are candidates for bariatric surgery (BS). Adequate screening would decrease the number of respiratory polygraphies (RPs).

Objective: To analyze the value of a sequential model consisting of a questionnaire (modified Dixon [DXM] vs STOP-Bang) and nocturnal pulse oximetry in patients who were candidates for BS. Read More

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http://dx.doi.org/10.1016/j.endinu.2020.03.006DOI Listing