1,345 results match your criteria Scorpion Envenomation


Mass-Spectrometry-Based Lipidome and Proteome Profiling of (Scorpiones: Buthidae) Venom.

Toxins (Basel) 2022 May 26;14(6). Epub 2022 May 26.

Institute of Inorganic and Analytical Chemistry, Justus Liebig University Giessen, 35392 Giessen, Germany.

Scorpion venom is a complex secretory mixture of components with potential biological and physiological properties that attracted many researchers due to promising applications from clinical and pharmacological perspectives. In this study, we investigated the venom of the Iranian scorpion (Simon, 1880) by applying mass-spectrometry-based proteomic and lipidomic approaches to assess the diversity of components present in the venom. The data revealed that the venom's proteome composition is largely dominated by Na- and K-channel-impairing toxic peptides, following the enzymatic and non-enzymatic protein families, e. Read More

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Characterization of Four Medically Important Toxins from Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment.

Toxins (Basel) 2022 May 26;14(6). Epub 2022 May 26.

Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apartado Postal 510-3, Cuernavaca 62250, Mexico.

scorpion venom is lethal to mammals. Analysis of the venom allowed the characterization of four lethal toxins named Chui2, Chui3, Chui4, and Chui5. scFv 10FG2 recognized well all toxins except Chui5 toxin, therefore a partial neutralization of the venom was observed. Read More

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Antibacterial Effects of Methanolic Extract on Wound Healing.

Molecules 2022 May 21;27(10). Epub 2022 May 21.

Faculty of Medicine, Taif University, Taif 21944, Saudi Arabia.

() is a small tree distributed throughout the Middle East. It was traditionally used in perfumes in countries in this area. In Saudi Arabia, it was used to treat wounds burns and as an antidote to scorpion stings. Read More

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Neutralizing Dromedary-Derived Nanobodies Against BotI-Like Toxin From the Most Hazardous Scorpion Venom in the Middle East and North Africa Region.

Front Immunol 2022 19;13:863012. Epub 2022 Apr 19.

Laboratoire des Biomolécules, Venins et Applications Théranostiques, Institut Pasteur Tunis, University Tunis El Manar, Tunis, Tunisia.

Scorpion envenoming is a severe health problem in many regions causing significant clinical toxic effects and fatalities. In the Middle East/North Africa (MENA) region, scorpion stings are responsible for devastating toxic outcomes in human. The only available specific immunotherapeutic treatment is based on IgG fragments of animal origin. Read More

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North American Envenomation Syndromes.

Emerg Med Clin North Am 2022 May;40(2):313-326

Department of Medical Toxicology, Banner University Medical Center Phoenix, 1012 East Willetta Street, Fl 2, Phoenix, AZ 85006, USA; University of Arizona College of Medicine, Phoenix, AZ, USA.

This review discusses the distinct envenomation syndromes produced by North American species of snakes and arthropods, specifically the Crotalinae subfamily of snakes, which includes cottonmouths, copperheads, and rattlesnakes; coral snakes; Latrodectus and Loxosceles species of arachnid; and Centruroides sculpturatus, the only species of North American scorpion capable of producing an envenomation syndrome. The authors discuss the epidemiology, pathophysiology, and presentation of these syndromes and emphasize the varying degrees to which these syndromes can manifest clinically. Finally, the management of each envenomation syndrome is addressed. Read More

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The Enzymatic Core of Scorpion Venoms.

Toxins (Basel) 2022 03 31;14(4). Epub 2022 Mar 31.

Traslational Bioengineering Department, Exact Sciences and Engineering University Center, Universidad de Guadalajara, Guadalajara 44430, Mexico.

Enzymes are an integral part of animal venoms. Unlike snakes, in which enzymes play a primary role in envenomation, in scorpions, their function appears to be ancillary in most species. Due to this, studies on the diversity of scorpion venom components have focused primarily on the peptides responsible for envenomation (toxins) and a few others (e. Read More

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-A Fruit with Multi-Benefits: Traditional Uses, Phytochemicals, Nutritional Value, and Bioactivities.

Nutrients 2022 Apr 6;14(7). Epub 2022 Apr 6.

Department of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.

(Langsat, Meliaceae) is a tropical fruit mainly found in Southeast Asian countries, particularly in Thailand, Malaysia, Indonesia, and the Philippines. Traditionally, it is utilized as a folk treatment for eye inflammation, ulcers, diarrhea, dysentery, fever, spasms, flatulence, worms, insect bites, scorpion stings, and malaria. Additionally, it is utilized as a mosquito repellent, skin moisturizer and whitening agent. Read More

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Low peripheral perfusion index values may indicate the need for antivenom in the early phase of scorpion envenomation.

Am J Emerg Med 2022 Jun 31;56:104-106. Epub 2022 Mar 31.

Adnan Menderes University Hospital Department of Emergency Medicine, Efeler, Aydın, Turkey.

Background: Scorpion envenomation may cause local symptoms as well as life-threatening situations including shock, and death. Antivenom administration is the cornerstone of therapy, meticulous patient selection is needed because of the possible side effects of the antivenom including anaphylaxis. Peripheral perfusion index (PPI) is a simple, non-invasive test that is widely used for the detection of peripheral hypoperfusion. Read More

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Scorpion envenomation in the state of São Paulo, Brazil: Spatiotemporal analysis of a growing public health concern.

PLoS One 2022 8;17(4):e0266138. Epub 2022 Apr 8.

Faculdade de Saúde Pública-Universidade De São Paulo, São Paulo, Brazil.

Scorpion envenomation is a significant public health concern in São Paulo, Brazil, and its incidence and mortality have increased in recent decades. The present study analyzed documented scorpion envenomation notifications from 2008 to 2018 throughout the 645 municipalities of São Paulo. Annual incidence and mortality rates were calculated and stratified according to sex and age. Read More

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Scorpion Species with Smaller Body Sizes and Narrower Chelae Have the Highest Venom Potency.

Toxins (Basel) 2022 03 17;14(3). Epub 2022 Mar 17.

Macroecology Lab, School of Natural Sciences, Ryan Institute, National University of Ireland Galway, H91 TK33 Galway, Ireland.

Scorpionism is a global health concern, with an estimation of over one million annual envenomation cases. Despite this, little is known regarding the drivers of scorpion venom potency. One widely held view is that smaller scorpions with less-developed chelae possess the most potent venoms. Read More

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The Pharmacological and Structural Basis of the AahII-Na1.5 Interaction and Modulation by the Anti-AahII Nb10 Nanobody.

Front Pharmacol 2022 28;13:821181. Epub 2022 Feb 28.

Laboratory of Cellular and Molecular Physiology UR 4667, UFR of Sciences, University of Picardie Jules Verne, Amiens, France.

Scorpion α-toxins are neurotoxins that target the fast inactivation mechanism of voltage-gated sodium (Na) channels leading to several neuro- and cardiotoxic effects in mammals. The toxin AahII is the most active α-toxin from the North African scorpion that slows the fast inactivation of Na channels. To fight scorpion envenomation, an anti-AahII nanobody named NbAahII10 (Nb10) was developed. Read More

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February 2022

Reconstruction of a massive defect of the neck after a scorpion sting: A case report.

Trauma Case Rep 2022 Jun 22;39:100624. Epub 2022 Feb 22.

Department of Plastic, Reconstructive and Hand Surgery & Burns ICU, General Hospital of Thessaloniki "G. Papanikolaou", Papanikolaou Avenue, Pilea Chortiatis, 570 10 Thessaloniki, Greece.

Introduction: Cutaneous traumas from scorpion sting envenomation are rare in European countries. Regarding Greece, complex is the most widespread scorpion species. The venom of these small dark brown arthropods, which shelter in woods, usually provokes local cutaneous symptoms: erythema, edema, cellulitis, urticarial plaques, ulcers and rarely skin necrosis. Read More

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Detection of areas vulnerable to scorpionism and its association with environmental factors in São Paulo, Brazil.

Acta Trop 2022 Jun 1;230:106390. Epub 2022 Mar 1.

Faculdade de Saúde Pública - Universidade De São Paulo, SP, Brazil.

Accidents caused by scorpions are considered a neglected condition and represent a major health problem in most tropical countries, especially for children and elderly people. In Brazil, scorpionism is recurrent in the southeast region, mainly in the state of São Paulo, due to the progressive increase in scorpions found in urban habitats. Thus, our study aimed to provide better insights into the geographic and epidemiological characteristics of scorpion envenomation in São Paulo state and identify the environmental factors that are associated with these accidents. Read More

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Voracity, reaction to stings, and survival of domestic hens when feeding on the yellow scorpion ().

J Venom Anim Toxins Incl Trop Dis 2022 11;28:e20210050. Epub 2022 Feb 11.

Institute of Biosciences, University of São Paulo (USP), São Paulo, SP, Brazil.

Background: Scorpionism is a worldwide problem that has already made thousands of victims, and multi-disciplinary approaches for controlling their populations are to be more successful. Hens are often mentioned as tools for controlling scorpions; however, systematic/experimental behavioral studies are not available. Moreover, there is no systematic information on the effect of scorpion venoms on hens. Read More

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February 2022

Hemorrhagic Stroke Revealing a Snake Bite: A Case Report.

Cureus 2022 Jan 4;14(1):e20935. Epub 2022 Jan 4.

Radiology, Centre Hospitalier Universitaire Mohammed VI, Marrakech, MAR.

In Morocco, envenomations caused by viper bites and scorpion stings are frequent and associated with high lethality. It occurs mainly during the summer season with a peak between June and August. It is a medical emergency requiring intensive care. Read More

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January 2022

Induced pathophysiological alterations by the venoms of the most dangerous Moroccan scorpions and : A comparative pathophysiological and toxic-symptoms study.

Hum Exp Toxicol 2022 Jan-Dec;41:9603271211072872

Laboratory of Venoms and Toxins, Pasteur Institute of Morocco, Casablanca, Morocco.

Scorpion envenomation is a serious public health issue.  () and  () are the most dangerous scorpions in Morocco. Despite their medical relevance, no study has yet related their kinetics of symptom apparition and the consequent tissue disorders at the same interval post-injection. Read More

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Cuban Blue Scorpion Venom and Lung Carcinoma: Is it Always True What Does Not Kill Me Makes Me Stronger?

Turk Thorac J 2021 May;22(3):265-266

Division of Allergy and Clinical Immunology, Department of Chest Diseases, Hacettepe University School of Medicine, Ankara, Turkey.

Historically snake, scorpion, and hymenoptera venom have been used to treat various diseases. It is well known that alternative and/or complementary treatment options are widely used, especially among cancer patients. The case we describe here has lung carcinoma and received blue scorpion venom as an alternative therapy. Read More

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A paper microfluidic device based colorimetric sensor for the detection and discrimination of elapid viper envenomation.

Analyst 2022 Feb 14;147(4):685-694. Epub 2022 Feb 14.

Aptamer Technology and Diagnostics Laboratory, Multidisciplinary Clinical and Translational Research Group, Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana 121001, India.

Snake bites are a neglected tropical disease, causing mortality and severe damage to various vital organs like the nervous system, kidneys and heart. There is increasing interest in designing new antivenom treatments that are more specific to particular groups (either taxonomic or regional) of species, given the increasing evidence that current polyvalent Indian antivenom is ineffective in many situations. Under these circumstances, being able to detect the species, or a group of species, responsible for the envenomation becomes important. Read More

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February 2022

Predictive Value of Glycemia and Free Fatty Acid Levels upon Admission of Children with Scorpionism in Egypt.

Am J Trop Med Hyg 2022 01 10;106(3):962-966. Epub 2022 Jan 10.

Department of Pediatrics, Faculty of Medicine, Assiut University, Egypt.

Scorpion envenomation is a life-threatening emergency and causes serious health problems in tropical and subtropical regions. The aim of this study was to correlate the serum levels of biochemical parameters at admission in children with scorpion envenomation with subsequent morbidity and mortality. It was a prospective, observational, and descriptive study conducted for scorpion-envenomed children who presented to emergency and intensive care units between April 2019 and September 2019. Read More

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January 2022

An infant with inconsolable crying.

Authors:
Abdullah Khan

Am J Emerg Med 2022 05 30;55:227.e5-227.e6. Epub 2021 Dec 30.

Dignity Health - St. Rose Dominican Hospital, Siena Campus Hospital, Department of Pediatric Emergency Medicine, Henderson, NV, 89052, USA. Electronic address:

Inconsolable crying in infants can be caused by as simple as infantile colic to wide variety of pathologies. A thorough history, physical examination followed by laboratory and radiologic evaluation can identify the cause of inconsolable crying. We present a case of infant who presented with inconsolable crying and after extensive workup no cause could ne identified. Read More

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[Venomous Animals in the Portuguese Territory: Clinical Management of Bites and Stings].

Acta Med Port 2021 Nov 2;34(11):784-795. Epub 2021 Nov 2.

Serviço de Doenças Infeciosas. Centro Hospitalar Universitário do Porto. Porto. Portugal.

There are many native species of animals with the potential to cause severe disease in Portugal. Of the four clinically relevant snake species, the vipers (Vipera latastei and Vipera seoanei) are the most concerning. They can cause severe disease and require in-hospital management, monitoring and specific treatment, including the administration of anti-snake venom serum. Read More

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November 2021

Scorpion Envenomation of Lactating Rats Decreases the Seizure Threshold in Offspring.

Toxins (Basel) 2021 11 30;13(12). Epub 2021 Nov 30.

Laboratory of Pharmacology, Butantan Institute, Av. Dr. Vital Brazil 1500, São Paulo 05503-900, Brazil.

Few data are available in the literature describing the long-term effects of envenoming in the perinatal period. In this study, the relationship between envenoming of lactating rats and possible behavioral changes in the mother and in her offspring were investigated. Lactating Wistar rats received a single dose of crude venom on postnatal days 2 (V2), 10 (V10) or 16 (V16), and had their maternal behavior evaluated. Read More

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November 2021

Pain-related toxins in scorpion and spider venoms: a face to face with ion channels.

Authors:
Sylvie Diochot

J Venom Anim Toxins Incl Trop Dis 2021 6;27:e20210026. Epub 2021 Dec 6.

Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS) UMR 7275 et Université Côte d'Azur (UCA), 06560 Valbonne, France. Institut de Pharmacologie Moléculaire et Cellulaire Centre National de la Recherche Scientifique Université Côte d'Azur Valbonne France.

Pain is a common symptom induced during envenomation by spiders and scorpions. Toxins isolated from their venom have become essential tools for studying the functioning and physiopathological role of ion channels, as they modulate their activity. In particular, toxins that induce pain relief effects can serve as a molecular basis for the development of future analgesics in humans. Read More

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December 2021

Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world's most diverse rainfores.

J Venom Anim Toxins Incl Trop Dis 2021 29;27:e20210028. Epub 2021 Nov 29.

Laboratory of Medical Entomology and Venomous Animals, Center of Tropical Medicine, Federal University of Pará (UFPA), Belém, PA, Brazil.

Venom from Amazonian scorpions of the genus contains components capable of eliciting a distinct clinical, mostly neurological, syndrome. This contrasts with the mainly autonomic manifestations produced after envenomation by congeneric southern and northern South American species. Herein, we summarize Pan-Amazonian scorpionism by synthesizing available toxinological, clinical, and molecular data gathered from all affected areas in Amazonia, including Brazil, Ecuador, Colombia, Peru, Venezuela, and French Guiana. Read More

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November 2021

Terrestrial venomous animals, the envenomings they cause, and treatment perspectives in the Middle East and North Africa.

PLoS Negl Trop Dis 2021 12 2;15(12):e0009880. Epub 2021 Dec 2.

Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.

The Middle East and Northern Africa, collectively known as the MENA region, are inhabited by a plethora of venomous animals that cause up to 420,000 bites and stings each year. To understand the resultant health burden and the key variables affecting it, this review describes the epidemiology of snake, scorpion, and spider envenomings primarily based on heterogenous hospital data in the MENA region and the pathologies associated with their venoms. In addition, we discuss the venom composition and the key medically relevant toxins of these venomous animals, and, finally, the antivenoms that are currently in use to counteract them. Read More

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December 2021

Ecological association between socioeconomic, occupational and sanitation factors and the occurrence of scorpionism in Brazil, 2007-2019.

Epidemiol Serv Saude 2021 Jul 26;30(4):e2021009. Epub 2021 Nov 26.

Universidade Federal da Bahia, Instituto de Biologia, Salvador, BA, Brasil.

Objective: To analyze ecological association between socioeconomic, occupational and sanitation characteristics and scorpionism in Brazil.

Methods: This was an ecological study with data on scorpion sting accidents reported on the Notifiable Health Conditions Information System (2007-2019). Negative binomial regression was used to estimate incidence rate ratios (IRR) and confidence intervals (95%CI). Read More

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Ischemic Stroke in a Child after a Probable Scorpion Sting.

Am J Trop Med Hyg 2021 11 29;106(3):959-961. Epub 2021 Nov 29.

Instituto Conmemorativo Gorgas de Estudios de la Salud, Investigador SNI-SENACYT, Ciudad de Panama, Panama.

Scorpion stings are common emergencies in the tropics. Species-specific antivenom therapies are available. However, fatalities resulting from scorpion stings remain a public health concern in many settings. Read More

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November 2021

New Data on Two Subspecies of , the Most Medically Important Scorpion Species in Northwestern Iran.

Arch Razi Inst 2021 1;76(3):591-597. Epub 2021 Sep 1.

Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Scorpions are among the most medically important arthropods in Iran, particularly northwestern areas. To date, five scorpion species, i.e. Read More

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November 2021

Comparison of the Scorpionism Caused by , and n. sp. aff. Scorpion Venoms in Colombia.

Toxins (Basel) 2021 10 25;13(11). Epub 2021 Oct 25.

Grupo de Investigaciones Herpetológicas y Toxinológicas, Centro de Investigaciones Biomédicas-Bioterio, Departamento de Biología, Facultad de Ciencias Naturales, Exactas y de la Educación, Universidad del Cauca, Popayán 190002, Colombia.

Among other scorpion species, Colombia has two genera of the Buthidae family and considered to be dangerous to humans. This research shares scientific knowledge aiming to a better understanding about the pathophysiological effects of such venoms. The venom of the three species: , , and . Read More

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October 2021

Biochemical and Proteomic Characterization, and Pharmacological Insights of Indian Red Scorpion Venom Toxins.

Front Pharmacol 2021 28;12:710680. Epub 2021 Sep 28.

Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, India.

The Indian red scorpion (Mesobuthus tamulus) is one of the world's deadliest scorpions, with stings representing a life-threatening medical emergency. This species is distributed throughout the Indian sub-continent, including eastern Pakistan, eastern Nepal, and Sri Lanka. In India, Indian red scorpions are broadly distributed in western Maharashtra, Saurashtra, Kerala, Andhra Pradesh, Tamil Nadu, and Karnataka; however, fatal envenomations have been recorded primarily in the Konkan region of Maharashtra. Read More

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September 2021