577 results match your criteria Scorpion Envenomation


Comparing clinical outcomes between two scorpion antivenom dosing strategies in children.

Clin Toxicol (Phila) 2019 Feb 7:1-5. Epub 2019 Feb 7.

c Department of Pediatrics , Arizona Children's Center at Maricopa Medical Center , Phoenix, AZ , USA.

Background And Objectives: The clinical course from scorpion envenomation can range from mild to life threatening, particularly in younger children. The F(ab') antivenom currently available in the United States is extremely effective for countering the neurotoxic effects but extremely expensive. This dose comparison study assesses clinical outcomes between two antivenom dosing strategies. Read More

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http://dx.doi.org/10.1080/15563650.2018.1551546DOI Listing
February 2019

A randomized comparative study between intravenous and intramuscular scorpion antivenom regimens in children.

Toxicon 2019 Mar 18;159:45-49. Epub 2019 Jan 18.

Pediatric Department, Faculty of Medicine, Assiut University, Assiut 71516, Egypt.

Background: Scorpion envenomation and its consequences represented a serious healthcare problem in Upper Egypt and considered to be an important cause of life-threatening emergency particularly in children.

Methods: One hundred patients presented to the emergency department of Assiut University Children Hospital with a history of scorpion sting aged less than 18 years were included in our randomized comparative trial during 2016. Two groups of patients were randomly categorized according to the route of administration of scorpion antivenom; intramuscular and intravenous with 50 patients in each group. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.01.004DOI Listing
March 2019
4 Reads
2.492 Impact Factor

Serological, pathological, and scintigraphic assessment of effects on renal dysfunction in rats.

Iran J Basic Med Sci 2018 Dec;21(12):1221-1225

Department of Pharmacology, Bushehr University of Medical Sciences, Bushehr, Iran.

Objectives: is one of the dangerous scorpions of Iran leading to acute kidney injury (AKI) especially in infants. The purpose of this animal study was to compare the serological, pathological and scintigraphic data to quickly predict the occurrence of this disorder.

Materials And Methods: In two groups of animals, each contained five rats, venom (1200 µg/Kg) were injected intravenously via the tail vein. Read More

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http://dx.doi.org/10.22038/ijbms.2018.31426.7585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312674PMC
December 2018
1 Read

Study on the obtaining of Tityus trivittatus venom in Argentina.

Toxicon 2019 Mar 3;159:5-13. Epub 2019 Jan 3.

Instituto Nacional de Producción de Biológicos, Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán", Ministerio de Salud, Argentina.

Envenomation by scorpions of the genus Tityus is an important public health problem in Argentina, involving near 8000 stings and 2 deaths each year. Treatment for envenomation is the use of specific antivenom and intensive hospital care. Antivenom is produced by the Ministry of Health and freely distributed throughout the country. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101193000
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http://dx.doi.org/10.1016/j.toxicon.2018.12.004DOI Listing
March 2019
9 Reads

Cerebrospinal inflammatory response following scorpion envenomation: role of histamine H1 and H3 receptors.

Inflammopharmacology 2019 Jan 2. Epub 2019 Jan 2.

USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32, El-Alia, Bab Ezzouar, Algiers, Algeria.

Background: The mechanism of the inflammatory process induced by scorpion venom in the cerebrospinal tissues has not yet been completely elucidated. Therefore, we aimed to investigate the role of histamine through its H1 and H3 receptors in this process.

Methods: Histamine H1 and H3 receptor antagonists, Hydroxyzine (10 mg/kg) and Betaserc (20 mg/kg), respectively, were administered by intraperitoneal route to mice 1 h before subcutaneous envenomation with a subletal dose (0. Read More

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http://dx.doi.org/10.1007/s10787-018-00553-6DOI Listing
January 2019
3 Reads

Study of Factors Contributing to Scorpion Envenomation in Arizona.

J Med Toxicol 2019 Jan 28;15(1):30-35. Epub 2018 Nov 28.

Center for Toxicology and Pharmacology Education and Research (CTPER), UACOMP, Phoenix, AZ, USA.

Introduction: Arizona has the highest incidence of scorpion envenomation reported to US poison control centers (PCCs). Most cases reported are from a residence, but specific details are limited.

Methods: Specialists at Arizona's two PCCs prospectively completed the Factors of Envenomation in Arizona Residences Survey (FEARS) for residential scorpion exposures reported during 4-week periods in the summer and winter. Read More

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http://link.springer.com/10.1007/s13181-018-0690-4
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http://dx.doi.org/10.1007/s13181-018-0690-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314927PMC
January 2019
19 Reads

Evidence of Direct Toxicological Effects of Scorpion Venom on Central Nervous System in Tunisian Children.

Case Rep Crit Care 2018 23;2018:8304375. Epub 2018 Oct 23.

Department of Intensive Care, Habib Bourguiba University Hospital, Sfax, Tunisia.

Background: Severe scorpion envenomation can lead to severe neurological manifestations, which are an indicator of the severity of the scorpion sting. The direct action of scorpion venom on the central nervous system can explain partly these neurological disorders.

Methods And Findings: We report a case of severe scorpion envenomation in 16-month-old boy with no pathological history admitted in ICU for severe scorpion envenomation. Read More

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http://dx.doi.org/10.1155/2018/8304375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218758PMC
October 2018
12 Reads

Influence of different processing techniques on the toxicity and biochemical characteristics of Tityus serrulatus scorpion venom.

Toxicon 2018 Dec 9;156:41-47. Epub 2018 Nov 9.

Laboratory of Biochemistry and Biophysics, Butantan Institute, Av. Dr. Vital Brasil 1500, 05503-900, São Paulo, SP, Brazil. Electronic address:

Studies of scorpion venoms have used different venom drying methods: lyophilization, desiccation, lyophilization after mixing with 0.9% saline or purified water and centrifugation. The aim of this study was to see if these different approaches cause some alteration in the composition of the venom or interfere with its biological effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183072
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http://dx.doi.org/10.1016/j.toxicon.2018.11.004DOI Listing
December 2018
24 Reads

Nanobodies as novel therapeutic agents in envenomation.

Biochim Biophys Acta Gen Subj 2018 Dec 30;1862(12):2955-2965. Epub 2018 Aug 30.

Biotechnology Research Center, Venom & Biotherapeutics Molecules Lab., Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: An effective therapy against envenoming should be a priority in view of the high number scorpion stings and snakebites. Serum therapy is still widely applied to treat the envenomation victims; however this approach suffers from several shortcomings. The employment of monoclonal antibodies might be an outcome as these molecules are at the core of a variety of applications from protein structure determination to cancer treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03044165183028
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http://dx.doi.org/10.1016/j.bbagen.2018.08.019DOI Listing
December 2018
8 Reads

Cerebrovascular Injury Following Scorpion Sting and Snake Envenomation: A Case Series.

Can J Neurol Sci 2018 Nov 5;45(6):669-674. Epub 2018 Oct 5.

1Unit V,Department of Internal Medicine,Christian Medical College,Vellore,Tamil Nadu,India.

Background: Neurological complications following snake and scorpion bite are diverse. Literature regarding patterns of cerebrovascular injury (CVI) and outcomes among these patients is scarce. This is a descriptive study of the clinical profile, brain imaging findings, mechanisms of injury, vascular territory involvement and outcomes of CVI following scorpion and snake envenomation, in a tertiary care center in South India. Read More

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http://dx.doi.org/10.1017/cjn.2018.328DOI Listing
November 2018
2 Reads

Mechanisms of toxic cardiomyopathy.

Authors:
Philippe Hantson

Clin Toxicol (Phila) 2019 Jan 27;57(1):1-9. Epub 2018 Sep 27.

a Department of Intensive Care , Cliniques St-Luc, Université catholique de Louvain , Brussels , Belgium.

Background: Dilated cardiomyopathy is a frequent disease responsible for 40-50% of cases of heart failure. Idiopathic cardiomyopathy is a primary disorder often related to familial/genetic predisposition. Before the diagnosis of idiopathic cardiomyopathy is made, clinicians must not only rule out viral and immune causes, but also toxic causes such as drugs, environmental agents, illicit substances and natural toxins. Read More

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http://dx.doi.org/10.1080/15563650.2018.1497172DOI Listing
January 2019
10 Reads

Myocarditis and Early Markers of Cardiac Response Associated with Scorpion Stings in Children.

Wilderness Environ Med 2018 Dec 23;29(4):471-478. Epub 2018 Sep 23.

Department of Pediatric Emergency, School of Medicine, Çukurova University, Adana, Turkey (Drs Gökay, Kendir, Nalbant, and Prof Ylmaz).

Introduction: A clinical course ranging from mild local findings to life-threatening systemic findings may occur after scorpion stings. The purpose of this study was to identify priority markers indicating scorpion sting-related cardiac involvement.

Methods: Our study was performed between July 2014, and September 2015 in the Çukurova University medical faculty pediatric emergency department, in Adana, Turkey. Read More

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http://dx.doi.org/10.1016/j.wem.2018.06.013DOI Listing
December 2018
3 Reads

Venomous Arachnid Diagnostic Assays, Lessons from Past Attempts.

Toxins (Basel) 2018 Sep 10;10(9). Epub 2018 Sep 10.

Departamento de Bioquímica e Imunologia, UFMG, Belo Horizonte 31270901, Brazil.

Diagnostic tests for arachnid accidents remain unavailable for patients and clinicians. Together with snakes, these accidents are still a global medical concern, and are recognized as neglected tropical issues. Due to arachnid toxins' fast mechanism of action, quick detection and quantification of venom is required to accelerate treatment decisions, rationalize therapy, and reduce costs and patient risks. Read More

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http://www.mdpi.com/2072-6651/10/9/365
Publisher Site
http://dx.doi.org/10.3390/toxins10090365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162545PMC
September 2018
16 Reads

Ultrasensitive sensing of Androctonus australis hector scorpion venom toxins in biological fluids using an electrochemical graphene quantum dots/nanobody-based platform.

Talanta 2018 Dec 27;190:182-187. Epub 2018 Jul 27.

University of Tunis El Manar, Faculty of sciences of Tunis, Laboratory of Analytical Chemistry and Electrochemistry (LR99ES15), Sensors and Biosensors Group, Campus Universitaire de Tunis El Manar, Tunis El Manar, 2092 Tunis, Tunisia.

Rapid and sensitive detection of low levels of scorpion venom toxins in biological fluids is of tremendous importance for decision-taking in cases of envenomation by scorpions stings. In Tunisia, at least 1200 severe envenomation cases by Androctonus australis hector (Aah) scorpion stings were reported annually. In this work, we report on a novel electrochemical immuno-sandwich to detect the Aah50 toxic fraction within the Aah scorpion venom using the bispecific nanobody format specially designed to highly recognize and neutralize the two most toxic molecules in the AahG50 venom fraction (i. Read More

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http://dx.doi.org/10.1016/j.talanta.2018.07.087DOI Listing
December 2018
17 Reads

Myocardial injury induced by scorpion sting envenoming and evidence of oxidative stress in Egyptian children.

Toxicon 2018 Oct 5;153:72-77. Epub 2018 Sep 5.

Medical Biochemistry Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

In the present study, 45 children in Upper Egypt (less than 16 years old) were admitted to the Pediatric Intensive Care Unit for scorpion envenomation (SE). They were compared with 30 apparently healthy children of matching age and sex as controls. Out of the studied victims, 35 children (78%) showed signs of severe envenomation, while 10 victims (22%) showed signs of mild envenomation. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.08.008DOI Listing
October 2018
1 Read
2.492 Impact Factor

Definition of the R-superfamily of conotoxins: Structural convergence of helix-loop-helix peptidic scaffolds.

Peptides 2018 Sep 21;107:75-82. Epub 2018 Jul 21.

Department of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431-0991, USA; Marine Biochemical Sciences, Chemical Sciences Division, National Institute of Standards and Technology, Hollings Marine Laboratory, 331 Fort Johnson Road, Charleston, SC 29412, USA. Electronic address:

The F14 conotoxins define a four-cysteine, three-loop conotoxin scaffold that produce tightly folded structures held together by two disulfide bonds with a CCCC arrangement (conotoxin framework 14). Here we describe the precursors of the F14 conotoxins from the venom of Conus anabathrum and Conus villepinii. Using transcriptomic and cDNA cloning analysis, the full-length of the precursors of flf14a and flf14b from the transcriptome of C. Read More

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http://dx.doi.org/10.1016/j.peptides.2018.06.002DOI Listing
September 2018
4 Reads

Antivenom use in bite and sting cases presenting to a public hospital.

Ulus Travma Acil Cerrahi Derg 2018 Jul;24(4):343-350

Department of Emergency Medicine, Karadeniz Technical University Faculty of Medicine,Trabzon-Turkey.

Background: To evaluate the distribution of bite and sting cases presenting to a district public hospital and the use of antivenom in scorpion sting and snake bite cases.

Methods: The demographic characteristics of patients with bites/stings reporting to a public hospital in 2014, the agent involved, the season of reporting, severity of clinical findings during presentation, and use of antivenom in scorpion sting and snake bite cases were evaluated retrospectively. χ2 test was used for statistical analysis. Read More

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http://dx.doi.org/10.5505/tjtes.2017.99692DOI Listing
July 2018
8 Reads

A global accounting of medically significant scorpions: Epidemiology, major toxins, and comparative resources in harmless counterparts.

Toxicon 2018 Sep 17;151:137-155. Epub 2018 Jul 17.

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

Scorpions are an ancient and diverse venomous lineage, with over 2200 currently recognized species. Only a small fraction of scorpion species are considered harmful to humans, but the often life-threatening symptoms caused by a single sting are significant enough to recognize scorpionism as a global health problem. The continued discovery and classification of new species has led to a steady increase in the number of both harmful and harmless scorpion species. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.07.007DOI Listing
September 2018
2 Reads

Developing recombinant phospholipase D1 (rPLD1) toxoid from Iranian Hemiscorpius lepturus scorpion and its protective effects in BALB/c mice.

Toxicon 2018 Sep 6;152:30-36. Epub 2018 Jul 6.

Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Hemiscorpius lepturus (H. lepturus) is one of the most dangerous scorpions and the most medically important scorpion in Iran. The clinical signs of H. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183029
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http://dx.doi.org/10.1016/j.toxicon.2018.07.003DOI Listing
September 2018
5 Reads
2.492 Impact Factor

Incidence, mechanisms and impact outcome of hyperglycaemia in severe scorpion-envenomed patients.

Ther Adv Endocrinol Metab 2018 Jul 3;9(7):199-208. Epub 2018 May 3.

Service de Réanimation médicale, Hôpital Habib Bourguiba, Sfax, Tunisie.

Hyperglycaemia is often observed in severe scorpion-envenomed patients. It is due to a severe autonomic storm with a massive release of catecholamines, increased glucagon levels, cortisol levels, and either decreased insulin levels or insulin resistance. The presence of hyperglycaemia is an indicator of severity in this specific condition. Read More

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http://dx.doi.org/10.1177/2042018818772779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022972PMC
July 2018
16 Reads

Acute kidney injury and pancreatitis due to scorpion sting: case report and literature review.

Rev Inst Med Trop Sao Paulo 2018 28;60:e30. Epub 2018 Jun 28.

Programas de Pós-Graduação em Saúde Coletiva e Ciências Médicas,, Curso de Medicina, Universidade de Fortaleza, Fortaleza, Ceará, Brazil.

Despite the high number of accidents due to scorpion stings in Brazil, severe cases in adults are seldomly reported. In the Northeast region of Brazil, Tityus stigmurus is the most prevalent species. A 69 year-old woman who was stung by a scorpion attended the emergency room 5 hours after envenomation. Read More

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http://dx.doi.org/10.1590/s1678-9946201860030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029862PMC
July 2018
6 Reads

TNF-α antagonist improves oxidative stress and lipid disorders induced by scorpion venom in the intestinal tissue.

Acta Trop 2018 Sep 21;185:307-313. Epub 2018 Jun 21.

USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria. Electronic address:

We previously reported that Androctonus australis hector (Aah) venom induces inflammation in several tissues, however limited information is available on its role in gastrointestinal tract. Here we evaluate the involvement of TNF-α in lipid metabolism in the small intestine after Aah envenomation. To address these issues, NMRI mice (3-month-old) were pre-treated with a TNF-α antagonist, 30 min prior to Aah venom injection. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.06.013DOI Listing
September 2018
6 Reads
2.270 Impact Factor

Development of a new approach of immunotherapy against scorpion envenoming: Avian IgYs an alternative to equine IgGs.

Int Immunopharmacol 2018 Aug 11;61:256-265. Epub 2018 Jun 11.

USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria. Electronic address:

Antivenom treatment has been largely used against scorpion stings. Despite their efficacy, the use of mammalian antivenoms may cause adverse effects due to the immune system activation. IgYs from hyperimmunized laying hens against venoms could be a promising alternative to equine IgGs due to the various benefits that these antibodies can provide. Read More

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http://dx.doi.org/10.1016/j.intimp.2018.06.013DOI Listing
August 2018
39 Reads
2.472 Impact Factor

LTB and PGE modulate the release of MIP-1α and IL-1β by cells stimulated with Bothrops snake venoms.

Toxicon 2018 Aug 9;150:289-296. Epub 2018 Jun 9.

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (FCFRP-USP), Avenida do Café, s/n, 14040-903, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Envenomation by Bothrops snakes promotes the release of inflammatory mediators, whose effects during this context are not well understood. These mediators include chemokines, cytokines and eicosanoids. Indeed, Bothrops snake envenomation results in local and systemic perturbations, including leukocyte recruitment, edema, pain and extensive tissue damage. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.06.066DOI Listing
August 2018
4 Reads

Scorpion envenomation: from a neglected to a helpful disease?

Intensive Care Med 2019 Jan 30;45(1):72-74. Epub 2018 May 30.

Intensive Care Unit and Research Laboratory LR12SP15, CHU Fatouma Bourguiba. University of Monastir, 5000, Monastir, Tunisia.

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http://dx.doi.org/10.1007/s00134-018-5226-5DOI Listing
January 2019
1 Read

Management of scorpion envenomation at the Faya-Largeau medical post, February-June, 2014.

Med Sante Trop 2018 May;28(2):150-153

Académie des sciences d'Outre-Mer, France.

Scorpion envenomation is common in northern Chad and associated with a high lethality rate. We report the management of 16 cases of scorpion envenomation in 2014 at our Faya-Largeau medical post. Our clinical experience revealed dissociated muscarinic symptoms in patients treated early in contrast to those treated later, who presented cardiogenic shock. Read More

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http://dx.doi.org/10.1684/mst.2018.0771DOI Listing

CD36 Shunts Eicosanoid Metabolism to Repress CD14 Licensed Interleukin-1β Release and Inflammation.

Front Immunol 2018 27;9:890. Epub 2018 Apr 27.

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.

Interleukin (IL)-1β is a potential target for treatment of several inflammatory diseases, including envenomation by the scorpion . In this context, bioactive lipids such as prostaglandin (PG)E and leukotriene (LT)B modulate the production of IL-1β by innate immune cells. Pattern recognition receptors (PRRs) that perceive venom (TsV), and orchestrate LTB, PGE, and cyclic adenosine monophosphate (cAMP) production to regulate IL-1β release are unknown. Read More

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http://dx.doi.org/10.3389/fimmu.2018.00890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934479PMC
April 2018
28 Reads

Efficacy of Scorpion Antivenom in Grade III and IV Scorpion Envenomation.

Indian J Pediatr 2018 07 27;85(7):576. Epub 2018 Apr 27.

Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

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http://dx.doi.org/10.1007/s12098-018-2688-yDOI Listing
July 2018
5 Reads
0.920 Impact Factor

A Relationship Between Clinical and Laboratory Characteristics in Children With Severe Scorpion Envenomation in Çukurova, Turkey.

Pediatr Emerg Care 2018 Apr 24. Epub 2018 Apr 24.

Department of Pediatric Intensive Care, School of Medicine, Çukurova University, Adana, Turkey.

Objective: Scorpion stings are an important health problem in many parts of the world. The aim of this study was to retrospectively examine cases of scorpion stings to evaluate their epidemiological, clinical, and laboratory features and to determine strategies that can reduce morbidity and mortality in these cases.

Methods: Scorpion stings experienced by children between 2007 and 2013 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001483DOI Listing
April 2018
9 Reads

genus species in arid regions: Ecological niche models, geographical distributions, and envenomation risk.

Vet World 2018 Mar 6;11(3):286-292. Epub 2018 Mar 6.

Department of Biology, Laboratory of Ecology and Environment, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakesh 40000, PO Box 2390, Morocco.

Aim: The objective of this study was to establish environmental factors related to scorpion species occurrence and their current potential geographic distributions in Morocco, to produce a current envenomation risk map and also to assess the human population at risk of envenomation.

Materials And Methods: In this study, 71 georeferenced points for all scorpion species and nine environmental indicators were used to generate species distribution models in Maxent (maximum entropy modeling of species geographic distributions) version 3.3. Read More

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http://dx.doi.org/10.14202/vetworld.2018.286-292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891841PMC

Scorpionism by spp. in Iran: a review.

J Venom Anim Toxins Incl Trop Dis 2018 2;24. Epub 2018 Mar 2.

1Social Determinants of Health (SDH) Research Center and Department of Environment Health, Kashan University of Medical Sciences, Kashan, Iran.

Scorpions are distributed throughout Iran and the genus is particularly important in this region. is the most significant species within the genus in the country. Since scorpionism provoked by comprises a medical emergency, the present study is focused on this important issue. Read More

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https://jvat.biomedcentral.com/articles/10.1186/s40409-018-0
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http://dx.doi.org/10.1186/s40409-018-0145-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833132PMC
March 2018
15 Reads

Involvement of Alveolar Macrophages and Neutrophils in Acute Lung Injury After Scorpion Envenomation: New Pharmacological Targets.

Inflammation 2018 Jun;41(3):773-783

Faculty of Biological Sciences, Laboratory Cellular and Molecular Biology, Department Cellular and Molecular Biology, USTHB, BP32, ELAlia, Bab Ezzouar, 16111, Algiers, Algeria.

Androctonus australis hector (Aah) scorpion venom is well known to induce a systemic inflammatory response associated with cell infiltration in lung and edema formation. The present study investigate (i) in vivo the evolution of lung and systemic inflammation triggered by Aah venom and (ii) analyze in vitro the signaling cascade, upstream of inflammatory cytokine expression after Aah venom-stimulated mouse alveolar macrophage (MH-S), the main resident immune cells in the lung. The inflammation induced by Aah venom was assessed in mice through inflammatory cell count, nitric oxide metabolite, and lactate dehydrogenase (LDH) activity in blood, concordantly with neutrophil sequestration in tissue and lung histology. Read More

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http://dx.doi.org/10.1007/s10753-018-0731-9DOI Listing
June 2018
3 Reads
1.921 Impact Factor

New and safe formulation for scorpion immunotherapy: Comparative study between saponin and FCA adjuvants associated to attenuated venom.

Vaccine 2018 03 23;36(13):1720-1727. Epub 2018 Feb 23.

USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, Bab-Ezzouar, Algiers, Algeria. Electronic address:

Envenoming by scorpion is a major health problem in Maghreb regions as well as in several regions of the world. Immunotherapy is the only effective treatment for scorpion stings. The immune sera are obtained from hyper-immunized animals with a formulation of venom associated to Freund's Complete Adjuvant (FCA). Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.02.071DOI Listing
March 2018
13 Reads
3.624 Impact Factor

Epidemiological and clinical characteristics of scorpionism in Shiraz (2012-2016); development of a clinical severity grading for Iranian scorpion envenomation.

Med J Islam Repub Iran 2017;31:27. Epub 2017 May 17.

Social Determinants of Health Research Center and, Department of Environmental Health, College of Health, Kashan University of Medical Sciences, Kashan, Iran.

Scorpionism is a public health problem in some provinces in Iran. The present study aimed to assess the clinical manifestations of scorpion envenomation in Shiraz and determine a clinical severity grading for Iranian scorpion envenomation in order to suggest a treatment guideline for emergency physicians. In this analytic retrospective study, all medical charts of patients with scorpion sting admitted in the adult medical toxicology center in Shiraz during July 2012 to July 2016 were assessed. Read More

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http://mjiri.iums.ac.ir/article-1-3941-en.html
Publisher Site
http://dx.doi.org/10.18869/mjiri.31.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804458PMC
May 2017
9 Reads

Second Dose of Scorpion Antivenom in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation.

Indian Pediatr 2018 Apr 9;55(4):315-318. Epub 2018 Feb 9.

Division of Pediatric Critical Care, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Objective: To study the effect of the second dose of scorpion antivenom in children with non-resolving or worsening scorpion sting envenomation.

Methods: 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Read More

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April 2018
3 Reads

Effect of Centruroides antivenom on reversal of methamphetamine-induced hyperkinesis and hyperthermia in rats.

J Pharm Pharmacol (Los Angel) 2017 Apr 20;5(1). Epub 2017 Apr 20.

Arizona Poison & Drug Information Center, College of Pharmacy, University of Arizona, Tucson, AZ, USA.

Context: Methamphetamine (MA) toxicity is a major health concern causing agitation, hyperkinesia, hyperthermia, and even death, affecting 24.7 million people worldwide. It has been observed that MA generates movement disorders in children similar to that of scorpion envenomation. Read More

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http://dx.doi.org/10.13188/2327-204X.1000020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771266PMC
April 2017
3 Reads

Update on the Epidemiology of Scorpion Envenomation in the South of Tunisia.

Wilderness Environ Med 2018 03 12;29(1):29-35. Epub 2018 Jan 12.

Emergency Department, Habib Bourguiba University Hospital, Sfax, Tunisia (Drs Chakroun-Walha, Karray, Jerbi, Nasri, Issaoui, Rebeh, Ksibi, and Rekik).

Introduction: Scorpion envenomation is still a frequent occurance in tropical and subtropical regions. In Tunisia, multiple studies on scorpion envenoming have contributed to an improved understanding of cardiac dysfunction and factors predictive of poor prognosis. These previous studies have contributed to the current standardized management of envenomed patients. Read More

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http://dx.doi.org/10.1016/j.wem.2017.09.011DOI Listing
March 2018
5 Reads

Injuries and envenomation by exotic pets in Hong Kong.

Hong Kong Med J 2018 02 5;24(1):48-55. Epub 2018 Jan 5.

Accident and Emergency Department, Tuen Mun Hospital, Tuen Mun, Hong Kong.

Introduction: Exotic pets are increasingly popular in Hong Kong and include fish, amphibians, reptiles, and arthropods. Some of these exotic animals are venomous and may cause injuries to and envenomation of their owners. The clinical experience of emergency physicians in the management of injuries and envenomation by these exotic animals is limited. Read More

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http://dx.doi.org/10.12809/hkmj176984DOI Listing
February 2018
1 Read

A comparative study of pathophysiological alterations in scorpionism induced by Tityus serrulatus and Tityus bahiensis venoms.

Toxicon 2018 Jan 21;141:25-33. Epub 2017 Nov 21.

Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, Brazil. Electronic address:

Scorpionism is a relevant public health problem in several countries in tropical and subtropical regions. In Brazil, Tityus serrulatus sting can induce acute lung injury in part as a consequence of inflammation. Despite the occurrence of other scorpions of Tityus genus in Brazilian scorpiofauna, the knowledge regarding pulmonary alterations is related to T. Read More

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http://dx.doi.org/10.1016/j.toxicon.2017.11.005DOI Listing
January 2018
36 Reads

Tityus serrulatus Scorpion Venom: In Vitro Tests and Their Correlation with In Vivo Lethal Dose Assay.

Toxins (Basel) 2017 11 23;9(12). Epub 2017 Nov 23.

Immunochemistry Laboratory, Butantan Institute, CEP 05503-900 São Paulo, Brazil.

Scorpion stings are the main cause of human envenomation in Brazil and, for the treatment of victims, the World Health Organization (WHO) recommends the use of antivenoms. The first step to achieve effective antivenom is to use a good quality venom pool and to evaluate it, with LD determination as the most accepted procedure. It is, however, time-consuming and requires advanced technical training. Read More

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http://dx.doi.org/10.3390/toxins9120380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744100PMC
November 2017
4 Reads

Aspidosperma pyrifolium Has Anti-Inflammatory Properties: An Experimental Study in Mice with Peritonitis Induced by Tityus serrulatus Venom or Carrageenan.

Int J Mol Sci 2017 Nov 11;18(11). Epub 2017 Nov 11.

Laboratory of Technology and Pharmaceutical Biotechnology (Tecbiofar), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Rua General Gustavo Cordeiro de Farias, S/N, Petrópolis 59012-570, Natal, Brazil.

Scorpions of the genus are responsible for the majority of envenomation in Brazil, the species being the most common and dangerous in South America. In this approach, we have investigated the ability of the aqueous extract from the leaves of in reducing carrageenan-induced inflammation and the inflammation induced by envenomation in mice. We also evaluated the cytotoxic effects of this extract, using the 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl-2H-tetrazolium (MTT) assay and the results revealed that the extract is safe. Read More

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http://www.mdpi.com/1422-0067/18/11/2248
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http://dx.doi.org/10.3390/ijms18112248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713218PMC
November 2017
18 Reads

A Stinging Suspicion Something Was Just Not Right: Methamphetamine Toxicity in Infant Mimics Scorpion Envenomation.

Pediatr Emerg Care 2017 Nov;33(11):e124-e125

From the Department of Pediatrics, University of Arizona, Tucson, AZ.

The sting from Centuroides sculpturatus, commonly known as the bark scorpion, is a serious medical problem and can be potentially fatal to young children. Centuroides sculpturatus envenomation can cause a wide spectrum of symptoms, often including autonomic dysfunction, cranial nerve abnormalities, and somatic motor abnormalities. We discuss a 6-month-old male infant who presented with signs and symptoms consistent with bark scorpion envenomation, later found to be secondary to methamphetamine toxicity. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001301DOI Listing
November 2017
18 Reads

Reactogenicity and safety assessment of an attenuated nanovaccine against scorpion envenomation: Preclinical study.

Vaccine 2017 12 20;35(48 Pt B):6657-6663. Epub 2017 Oct 20.

USTHB, Faculty of Biological Sciences: Laboratory of Cellular and Molecular Biology, BP32 El-Alia, Bab-Ezzouar, Algiers, Algeria. Electronic address:

An attenuated nanovaccine (Nps - V) has been developed to protect humans from fatal scorpion envenomation in at-risk regions. This study was conducted to evaluate the toxicity and the local reactogenicity of the Nps - V nanovaccine developed against Androctonus australis hector (Aah) venom. Assessment of the systemic inflammatory response and serum cytokine levels were evaluated in vaccinated mice with 100μg of irradiated Aah venom (V) encapsulated or not into polymeric calcium-alginate nanoparticles (Nps) and injected by subcutaneous (s. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X173142
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http://dx.doi.org/10.1016/j.vaccine.2017.10.028DOI Listing
December 2017
5 Reads

Geographic Distribution of Scorpion Exposures in the United States, 2010-2015.

Am J Public Health 2017 12 19;107(12):1958-1963. Epub 2017 Oct 19.

A. Min Kang is with the Department of Child Health and Department of Medicine, University of Arizona College of Medicine-Phoenix. Daniel E. Brooks is with the Department of Emergency Medicine and Department of Medicine, University of Arizona College of Medicine-Phoenix.

Objectives: To determine the geographic distribution of scorpion envenomations in the United States by zip code, with particular attention to the neurotoxic Centruroides sculpturatus (Arizona bark scorpion), for which an antivenom is available.

Methods: We obtained scorpion exposure cases for 2010 to 2015 from the National Poison Data System. Using geographic information systems software, we mapped total exposures and incidence rates for 9 states that reported more than 100 annual calls. Read More

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http://dx.doi.org/10.2105/AJPH.2017.304094DOI Listing
December 2017
3 Reads

The envenomation of general physiology throughout the last century.

Authors:
Jon T Sack

J Gen Physiol 2017 Nov 11;149(11):975-983. Epub 2017 Oct 11.

Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA

Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and smarting spiders. For physiologists, toxins are integral chemical tools that hijack life's fundamental processes with remarkable molecular specificity. Read More

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http://dx.doi.org/10.1085/jgp.201711856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675992PMC
November 2017
1 Read

Neutralization Capacity of Monovalant Antivenom Against Existing Lethal Scorpions in the Turkish Scorpiofauna.

Iran J Pharm Res 2017 ;16(2):653-660

Alaşehir Vocational School, Celal Bayar University, Alaşehir, Manisa, Turkey.

In this study, and venom samples were compared for lethality, effects and proteins. Neutralization capacity of monovalent antivenom (RSHA anti-Ac) was tested against the lethal effects of the venoms. Venom was obtained from mature scorpions by electrical stimulation of the telson. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603874PMC
January 2017
14 Reads

Scorpion-related cardiomyopathy and acute pulmonary edema in a child who is stung by .

Turk J Emerg Med 2017 Sep 18;17(3):104-108. Epub 2017 Mar 18.

Manisa Celal Bayar University Alasehir Vocational High School, 45600, Alaşehir, Manisa, Turkey.

Venom of (Scorpiones: Buthidae) is an extremely toxic one and it stimulates voltage-gated sodium and potassium channels. In case of a stung by this scorpion; excessive catecholamine release occur and it impairs left ventricle contractility and consequently a heart failure occurs (scorpion sting-related cardiomyopathy). In addition to this cardiac-induced acute pulmonary, edema may occur in severe cases too. Read More

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http://dx.doi.org/10.1016/j.tjem.2016.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608594PMC
September 2017
16 Reads

Inverted Takotsubo syndrome in Androctonus australis scorpion envenomation.

Clin Toxicol (Phila) 2018 May 14;56(5):381-383. Epub 2017 Sep 14.

a Intensive Care Unit and Research Laboratory LR12SP15 , CHU Fatouma Bourguiba, University of Monastir , Monastir , Tunisia.

Context: The nature of scorpion-related cardiomyopathy is still a matter of debate where specific toxin-induced cardiomyopathy, ischemic, or catecholaminergic cardiomyopathy is advocated as well. We report two cases of Takotsubo syndrome following envenomation by Androctonus australis, bringing new evidence for the fundamental role of catecholamines in the pathogenesis of this cardiomyopathy. Case 1: A woman aged 36 presented with pulmonary edema and shock following scorpion envenomation. Read More

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http://dx.doi.org/10.1080/15563650.2017.1377221DOI Listing
May 2018
9 Reads
3.120 Impact Factor

Centruroides sculpturatus envenomation in three adult patients requiring treatment with antivenom.

Clin Toxicol (Phila) 2018 Apr 5;56(4):294-296. Epub 2017 Sep 5.

e Arizona Poison & Drug Information Center, The University of Arizona College of Pharmacy, Center for Toxicology Pharmacology Education and Research , University of Arizona College of Medicine Phoenix , Tucson , AZ , USA.

Context: Envenomation by Centruroides sculpturatus can manifest with cranial nerve dysfunction and neuromuscular hyperactivity. While these symptoms are most commonly seen in young children, they may also be seen in adults.

Case Details: Three cases of adult patients are presented with grades III & IV scorpion envenomation. Read More

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https://www.tandfonline.com/doi/full/10.1080/15563650.2017.1
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http://dx.doi.org/10.1080/15563650.2017.1371310DOI Listing
April 2018
8 Reads

Dangerous arachnids-Fake news or reality?

Toxicon 2017 Nov 1;138:173-183. Epub 2017 Sep 1.

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address:

The public perception of spiders and scorpions is skewed towards the potential harm they can inflict in humans, despite recent scientific evidence that arachnid venom components might be useful as bioinsecticides or even human therapeutics. Nevertheless, arachnids are becoming more popular as pets in Europe, America and Asia, raising the question for regulatory agencies in these regions as to whether they need to take measurements to protect their citizens. In order to decide upon the necessary regulatory steps, they first need to determine which arachnids are actually dangerous to humans. Read More

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http://dx.doi.org/10.1016/j.toxicon.2017.08.024DOI Listing
November 2017
22 Reads