389 results match your criteria Scoliosis Infantile

A comparison of the inflammatory host response to particulate debris adjacent to unlocked and locked screws of a growth guidance system for early onset scoliosis.

Eur Spine J 2022 Jun 13. Epub 2022 Jun 13.

Kobe Medical Center, Suma Ward, Nishiochiai, 3 Chome-1-1, Kobe, Hyogo, 654-0155, Japan.

Purpose: The SHILLA™ Growth Guidance system is a stainless-steel rod and screw system used for Early Onset Scoliosis which incorporates a unique flanged set screw designed to capture the rod, while allowing it to slide as the patient grows. Concomitant with this design is the potential for generation of wear debris and for an inflammatory host response. We hypothesized that the magnitude of the host response adjacent to the unlocked screws and rods would be greater than the host response to the locked rod/screws. Read More

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Weight gain and gastrostomy tube safety during serial body casting for early onset scoliosis.

Spine Deform 2022 Apr 21. Epub 2022 Apr 21.

Division of Orthopaedics, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., 2nd Floor Wood Building, Philadelphia, PA, 19104, United States.

Purpose: Serial casting has been shown to improve curve deformity for patients with early-onset scoliosis (EOS). However, despite prior literature demonstrating the importance of weight and nutrition in EOS patients, there is limited information regarding complications and weight gain ability for children undergoing serial casting. Additionally, parents of patients undergoing serial casting often have concerns regarding weight gain and patient comfort, which tend to be amplified in patients with gastrostomy tubes (g-tubes). Read More

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Prolonged Brace Treatment Does Not Result in Improved Acetabular Indices in Infantile Dislocated Hips.

J Pediatr Orthop 2022 May-Jun 01;42(5):e409-e413

The Hospital for Sick Children, Toronto, Ontario, Canada.

Background: The Pavlik harness (PH) is commonly used to treat infantile dislocated hips. However, significant variability exists in the duration of brace treatment after successful reduction of the dislocated hip. The purpose of this study was to evaluate the effect of prescribed time in brace on acetabular index (AI) at two years of age using a prospective, international, multicenter database. Read More

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Craniofacial and dentoalveolar morphology in individuals with Prader-Willi syndrome: a case-control study.

Orphanet J Rare Dis 2022 02 22;17(1):77. Epub 2022 Feb 22.

TAKO-Centre, National Resource Centre for Oral Health in Rare Medical Conditions, Lovisenberg Diaconal Hospital, Pb 4970 Nydalen, 0440, Oslo, Norway.

Background: Prader-Willi syndrome (PWS) is a complex multisystem genetic disorder with distinct genetic and clinical features. Among other clinical symptoms, PWS is characterized by severe infantile hypotonia with feeding problems, childhood onset hyperphagia, obesity, scoliosis, short stature combined with growth hormone deficiency and developmental delay. PWS is associated with facial dysmorphology, orofacial dysfunction, oral abnormalities, low salivary flow and subsequent severe tooth wear. Read More

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February 2022

S2-Alar-iliac screw fixation for paediatric neuromuscular scoliosis: Preliminary results after two years.

Orthop Traumatol Surg Res 2022 02 7:103234. Epub 2022 Feb 7.

Service de chirurgie infantile à orientation orthopédique, Hôpital Universitaire Robert Debré, Assistance Publique - Hôpitaux de Paris (AP-HP), Université de Paris, 48 Bd Sérurier, 75019 Paris, France.

Background: Correcting pelvic obliquity is among the main goals of surgery for neuromuscular scoliosis. Spino-pelvic fixation must be stable and capable of withstanding the considerable mechanical forces applied at the lumbo-sacral junction. Selection of the best anchoring option is therefore crucial. Read More

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February 2022

Treatment of infantile idiopathic scoliosis using a novel thoracolumbosacral orthosis: a case report.

J Med Case Rep 2022 Jan 5;16(1):20. Epub 2022 Jan 5.

Faculty of Medicine, Health and Human Sciences, Macquarie University, Macquarie Park, NSW, 2109, Australia.

Background: The recommended treatment for mild to moderate infantile idiopathic scoliosis curves involves serial casting. There are concerns, however, regarding the safety of repeated casting in very young children owing to the requirement for anesthetization during the casting process. Very little research has been conducted on the influence of bracing as an initial treatment for scoliosis in this age group. Read More

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January 2022

Ligamentum Teres Transfer During Medial Open Reduction in Patients with Developmental Dysplasia of the Hip.

Iowa Orthop J 2021;41(1):47-53

University of California San Diego School of Medicine, La Jolla, CA, USA.

Background: The ligamentum teres (LT) is believed to have a number of functions, including a role in hip stability, nociception, proprioception, vascular supply to the femoral head, and synovial fluid circulation. The LT is often excised in the process of performing a medial open reduction (MOR) of the hip. We sought to conduct a retrospective review of hips undergoing a MOR for dislocated infantile developmental dysplasia of the hip (DDH) to compare clinical and radiographic outcomes for patients with and without LT reconstruction. Read More

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October 2021

Development of orthosis following EDF serial casting for infantile scoliosis.

Stud Health Technol Inform 2021 Jun;280:187-191

Dept. Of Orthopaedic Surgery, Children's Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA.

Elongation-de-rotation-flexion (EDF) casting is a popular treatment for early-onset-scoliosis (EOS). However, casting every 2 to 3 months using general anesthesia may affect cognitive function.[1,2] Aims of this study: 1) to develop a new orthosis for EOS treatment based on EDF technique (EDFO) and traction frame; 2) to evaluate emerging radiographic results from treatment. Read More

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Bracing for infantile scoliosis: no sedation needed.

Stud Health Technol Inform 2021 Jun;280:184-186

Boston Orthotics and Prosthetics, Boston, MA, USA.

Mehta casting technique applied under anesthesia is standard treatment for infantile scoliosis (IIS). However, concern has been raised about frequent anesthesia in children less than three years. The development of a customized thoracolumbar sacral orthosis (TLSO) could avoid the risks of Mehta casting. Read More

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Follow-up of an Elongation Bending Derotation Brace in the treatment of infantile scoliosis.

J Thometz X C Liu

Stud Health Technol Inform 2021 Jun;280:174-178

Musculoskeletal Functional Assessment Center, Children's Wisconsin; Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Since 2013, an elongation bending derotation brace (EBDB) has been developed and applied to EOS in our institution. The goals of the study were: 1) to compare radiographic changes before the use of EBDB (Pre-B), in brace (IB), and after the use of EBDB (Post-B) in a minimal two year follow-up; 2) to determine the compliance with the EBDB. Thirteen children diagnosed with an infantile scoliosis (IS) were retrospectively recruited. Read More

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Further delineation of PIGB-related early infantile epileptic encephalopathy.

Eur J Med Genet 2021 Oct 20;64(10):104268. Epub 2021 Jun 20.

Department of Pediatrics, Child Neurology Unit, Azienda USL- IRCCS di Reggio Emilia, Reggio Emilia, Italy; Department of Pediatrics, Pediatric Neurophysiology Laboratory, Azienda USL- IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Pathogenic variants in phosphatidylinositol glycan anchor biosynthesis class B (PIGB) gene have been first described as the cause of early infantile epileptic encephalopathy 80 (EIEE-80) in 2019. This disorder, an inherited glycosylphosphatidylinositol deficiency, is associated with a complex neurologic phenotype, including developmental delay, early-onset epilepsy and peripheral neuropathy. We report on a 5 year-old girl born from consanguineous parents, manifesting severe global developmental delay with absent speech, mixed peripheral polyneuropathy, hypotonia, bilateral equino-varo-supinated-cavus foot, early-onset scoliosis, elevated serum alkaline phosphatase and a single episode of febrile status epilepticus. Read More

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October 2021

Efficacy of bracing in early infantile scoliosis: a 5-year prospective cohort shows that idiopathic respond better than secondary-2021 SOSORT award winner.

Eur Spine J 2021 12 6;30(12):3498-3508. Epub 2021 Jun 6.

ISICO (Italian Scientific Spine Institute), Milan, Italy.

Purpose: In conservative early onset scoliosis treatment, interest in bracing is growing because repeated general anaesthesia (required by casting) has been questioned for possible brain damages. We aimed to check the results in the medium term of bracing, comparing idiopathic (IIS) to secondary (SIS) infantile scoliosis.

Methods: We performed a retrospective study in a consecutive prospective cohort. Read More

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December 2021

Early dynamic changes within the spine following posterior fusion using hybrid instrumentation in adolescents with idiopathic scoliosis: a gait analysis study.

Arch Orthop Trauma Surg 2021 May 18. Epub 2021 May 18.

Pediatric Orthopedics, Timone Enfants, Aix Marseille University, 264 rue Saint Pierre, 13005, Marseille, France.

Introduction: In adolescent idiopathic scoliosis (AIS) patients, mechanical consequences of posterior spinal fusion within the spine remain unclear. Through dynamic assessment, gait analysis could help elucidating this particular point. The aim of this study was to describe early changes within the spine following fusion with hybrid instrumentation in adolescents with idiopathic scoliosis, using gait analysis MATERIALS AND METHODS: We conducted a single-centre prospective study including AIS patients scheduled for posterior spinal fusion (PSF) using hybrid instrumentation with sublaminar bands. Read More

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Clinical and genetic characteristics of Chinese patients with reducing body myopathy.

Neuromuscul Disord 2021 05 12;31(5):442-449. Epub 2021 Feb 12.

Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Reducing body myopathy (RBM) is a rare myopathy characterized by reducing bodies (RBs) in morphological presentation. The clinical manifestations of RBM present a wide clinical spectrum, varying from infantile lethal form through childhood and adult benign forms. FHL1 gene is the causative gene of RBM. Read More

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The Demographics and Epidemiology of Infantile, Juvenile, and Adolescent Idiopathic Scoliosis in a Southern California Integrated Health Care System.

Spine (Phila Pa 1976) 2021 Nov;46(21):1468-1477

Kaiser Los Angeles Medical Center Department of Orthopedics, Los Angeles, CA.

Study Design: Prognostic study, Level III.

Objectives: The aim of this study was to determine the incidence and demographics of idiopathic scoliosis (IS) in a large cohort of children in a Southern California integrated healthcare system, and to identify the demographic or clinical factors associated with the greatest risk of IS.

Summary Of Background Data: Although many authors have reported on the incidence and prevalence of IS in children, there have been few incidence studies in the United States on large, self-contained populations. Read More

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November 2021

A Novel Synergistic Association of Variants in PTRH2 and KIF1A Relates to a Syndrome of Hereditary Axonopathy, Outer Hair Cell Dysfunction, Intellectual Disability, Pancreatic Lipomatosis, Diabetes, Cerebellar Atrophy, and Vertebral Artery Hypoplasia.

Cureus 2021 Feb 6;13(2):e13174. Epub 2021 Feb 6.

Internal Medicine: Diabetes and Endocrinology, Institute of Diabetology, Stanley Medical College & Hospital, Chennai, IND.

The gene PTRH2 encodes a protein with peptidyl-tRNA hydrolase activity and is involved in the translation process in protein synthesis. The kinesin family member 1-A (KIF1A) gene encodes a molecular motor involved in axonal transport along microtubules. Mutations in these genes lead to respective phenotypical conditions that have been reported in the literature. Read More

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February 2021

Index radiographic measurements in the prediction of progression in infantile idiopathic scoliosis: a comparative analysis and description of a novel predictive model.

Eur Spine J 2021 07 9;30(7):1858-1864. Epub 2021 Mar 9.

The Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, UK.

Purpose: To assess the comparative accuracy of commonly utilised index radiological measurements in the prognosis of infantile idiopathic scoliosis (IIS) and build a parsimonious prognostic model utilising these measurements.

Methods: This was a retrospective analysis of a UK population of patients with IIS. Index radiological parameters were analysed, and outcome of their condition was determined over long-term follow-up. Read More

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Adult phenotype in Koolen-de Vries/ haploinsufficiency syndrome.

J Med Genet 2022 02 24;59(2):189-195. Epub 2020 Dec 24.

Dipartimento Universitario Scienze della Vita e Sanità Pubblica, Sezione di Medicina Genomica, Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Roma, Italy

Background: Koolen-de Vries syndrome (KdVS) is a multisystem neurodevelopmental disorder caused by 17q21.31 deletions or mutations in . It was mainly described in children. Read More

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February 2022

Posterior vertebral column resection for pediatric rigid spinal deformity.

Orthop Traumatol Surg Res 2020 Dec 14:102797. Epub 2020 Dec 14.

Service de chirurgie orthopédique infantile, CHU de Robert-Debré, Paris, France.

Introduction: Surgery for pediatric spinal deformity may involve vertebral osteotomies in complex cases. Vertebral column resection (VCR) is the most technically demanding procedure, with the severest morbidity. It can use a double anterior and posterior approach (APVCR), though a single posterior approach (PVCR) is gaining in popularity. Read More

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December 2020

Infantile Idiopathic Scoliosis: Outcomes of Brace Treatment until Skeletal Maturity or Spinal Fusion.

Arch Bone Jt Surg 2020 Nov;8(6):696-702

Department of Orthopaedic Surgery, Shafa Yahyaiian ospital, Iran University of Medical Sciences, Tehran, Iran.

Background: Serial casting under general anesthesia, which is considered as a gold standard of treatment for patients with infantile idiopathic scoliosis (IIS), can lead to significant negative neurodevelopmental effects. Therefore, the appropriateness of this type of treatment is controversial. Brace treatment is one alternative method of treatment for IIS patients. Read More

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November 2020