361 results match your criteria Scoliosis Infantile


[Conservative and surgical treatment of idiopathic scoliosis].

Orthopade 2020 Jul;49(7):635-646

Klinik für Kinderorthopädie und Kindertraumatologie, Helios Klinikum Emil von Behring, Walterhöferstr. 11, 14165, Berlin, Deutschland.

Idiopathic scoliosis is the largest group of all forms of scoliosis in the growth phase accounting for 80-90%. A distinction is made between idiopathic infantile (0-3 years), juvenile (4-10 years) and adolescent scoliosis (>10 years), depending on the age when scoliosis appears. The treatment depends on the skeletal age, the Cobb angle and the progression behavior of scoliosis. Read More

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http://dx.doi.org/10.1007/s00132-020-03928-2DOI Listing

Casting in infantile idiopathic scoliosis as a temporising measure: A systematic review and meta-analysis.

SAGE Open Med 2020 26;8:2050312120925339. Epub 2020 May 26.

Service of Pediatric Orthopaedics, Department of Child and Adolescent, University Hospital of Geneva, Geneva, Switzerland.

Objective: Treatment of infantile idiopathic scoliosis remains vague. Because implantation of temporary telescopic devices carries a high risk of complications, interest in the older technique of serial casting is growing as a temporising measure before invasive procedures. The goal of this review was to meta-analyse studies examining the effect and safety of casting in infantile idiopathic scoliosis. Read More

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http://dx.doi.org/10.1177/2050312120925339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268564PMC

Awake serial body casting for the management of infantile idiopathic scoliosis: is general anesthesia necessary?

Spine Deform 2020 May 7. Epub 2020 May 7.

Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Study Design: It is a retrospective cohort study.

Objectives: To compare the radiographic and clinical outcomes of serial body casting for infantile idiopathic scoliosis (IIS) with versus without the use of general anesthesia (GA). Serial body casting for IIS has traditionally been performed under GA. Read More

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http://dx.doi.org/10.1007/s43390-020-00123-3DOI Listing

MRI utilization and rates of abnormal pretreatment MRI findings in early-onset scoliosis: review of a global cohort.

Spine Deform 2020 Apr 24. Epub 2020 Apr 24.

Department of Orthopaedic Surgery, University of California, San Diego, San Diego, CA, USA.

Study Design: Retrospective review OBJECTIVES: To report the frequency of pretreatment magnetic resonance imaging (MRI) utilization and rates and types of intra-spinal abnormalities identified on MRI in patients with early-onset scoliosis (EOS). MRI can help identify spinal cord abnormalities in patients with EOS.

Methods: We reviewed data from patients enrolled from 1993-2018 in an international EOS registry. Read More

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http://dx.doi.org/10.1007/s43390-020-00115-3DOI Listing

Kosaki overgrowth syndrome: A novel pathogenic variant in PDGFRB and expansion of the phenotype including cerebrovascular complications.

Clin Genet 2020 Jul 4;98(1):19-31. Epub 2020 May 4.

Centre de Génétique et Centre de référence « Anomalies du Développement et Syndromes Malformatifs », Hôpital d'Enfants, Centre Hospitalier Universitaire de Dijon, Dijon, France.

Heterozygous activating variants in platelet-derived growth factor, beta (PDGFRB) are associated with phenotypes including Kosaki overgrowth syndrome (KOGS), Penttinen syndrome and infantile myofibromatosis (IM). Here, we present three new cases of KOGS, including a patient with a novel de novo variant c.1477A > T p. Read More

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http://dx.doi.org/10.1111/cge.13752DOI Listing
July 2020
3.931 Impact Factor

Does static trunk motion analysis reflect its true position during daily activities in adolescent with idiopathic scoliosis?

Orthop Traumatol Surg Res 2020 Mar 20. Epub 2020 Mar 20.

Orthopédie infantile, hôpital d'enfants de la Timone, Aix-Marseille université, 264, rue Saint-Pierre, 13005 Marseille, France; Plateforme d'analyse de la motricité, hôpital de la Timone, Aix-Marseille université, Marseille, France.

Introduction: Adolescent idiopathic scoliosis is common condition in pediatric orthopedics that is generally analyzed with standard radiographs. However, the conditions under which the radiographs are made are completely different than the position that patients use during day-to-day activities. We hypothesized that the trunk's static position differs from its dynamic one. Read More

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http://dx.doi.org/10.1016/j.otsr.2019.12.023DOI Listing

Serial elongation derotation flexion casting in children with infantile and juvenile scoliosis.

Ann Transl Med 2020 Jan;8(2):24

Pediatric Orthopedic Department, Clinique St. Roch, Montpellier, France.

Infantile (IS) and juvenile scoliosis (JS) are among the most challenging conditions pediatric orthopedic surgeons are facing in the present days. However, the best treatment of IS and JS is still debated and it remains controversial, at least for some aspects. Untreated early onset spinal deformities may lead to pulmonary and heart compromise. Read More

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http://dx.doi.org/10.21037/atm.2019.08.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995919PMC
January 2020

Regulation of terminal hypertrophic chondrocyte differentiation in mutant mice modeling infantile idiopathic scoliosis.

Dis Model Mech 2019 12 17;12(12). Epub 2019 Dec 17.

Department of Pediatrics, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd, The University of Texas at Austin, Dell Medical School, Austin, TX 78723, USA

Idiopathic scoliosis (IS) is the most common type of musculoskeletal defect affecting children worldwide, and is classified by age of onset, location and degree of spine curvature. Although rare, IS with onset during infancy is the more severe and rapidly progressive form of the disease, associated with increased mortality due to significant respiratory compromise. The pathophysiology of IS, in particular for infantile IS, remains elusive. Read More

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http://dx.doi.org/10.1242/dmm.041251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955203PMC
December 2019

Serial casting in early onset scoliosis: syndromic scoliosis is no contraindication.

BMC Musculoskelet Disord 2019 Nov 20;20(1):554. Epub 2019 Nov 20.

Department of Pediatric Orthopaedic Surgery, Children's Hospital Hamburg-Altona, Hamburg, Germany.

Background: Serial casting is a treatment for early onset scoliosis (EOS) in young children to achieve curve correction before bracing or to postpone initial surgical treatment until the patient is older. Good results have been reported for patients with idiopathic early onset scoliosis (IS). However, there are few reports of results in non-idiopathic cases, and the benefits of non-surgical methods in the syndromic-associated early onset scoliosis subgroup are unknown. Read More

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http://dx.doi.org/10.1186/s12891-019-2938-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868715PMC
November 2019

Kosaki overgrowth syndrome: A newly identified entity caused by pathogenic variants in platelet-derived growth factor receptor-beta.

Am J Med Genet C Semin Med Genet 2019 12 11;181(4):650-657. Epub 2019 Nov 11.

Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.

Specific classes of de novo heterozygous gain-of-function pathogenic variants of the PDGFRB (platelet-derived growth factor receptor-beta) cause a distinctive overgrowth syndrome, named the Kosaki overgrowth syndrome (KOGS) (OMIM #616592). Until now, six patients with this condition have been reported in the literature. In addition to skeletal overgrowth, these patients exhibit hyperelastic, translucent, and fragile skin, scoliosis, progressive loss of subcutaneous adipose tissue, skull deformity, infantile myofibromas, neuropsychiatric symptoms, and arachnoid cysts in the posterior fossa and periventricular white matter signal abnormalities on neuroimaging. Read More

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http://dx.doi.org/10.1002/ajmg.c.31755DOI Listing
December 2019

The Genetic Landscape of Epilepsy of Infancy with Migrating Focal Seizures.

Ann Neurol 2019 12;86(6):821-831

Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Melbourne, Victoria, Australia.

Objective: Epilepsy of infancy with migrating focal seizures (EIMFS) is one of the most severe developmental and epileptic encephalopathies. We delineate the genetic causes and genotype-phenotype correlations of a large EIMFS cohort.

Methods: Phenotypic and molecular data were analyzed on patients recruited through an international collaborative study. Read More

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http://dx.doi.org/10.1002/ana.25619DOI Listing
December 2019
1 Read

Crisponi/cold-induced sweating syndrome: Differential diagnosis, pathogenesis and treatment concepts.

Clin Genet 2020 Jan 16;97(1):209-221. Epub 2019 Sep 16.

Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy.

Crisponi/cold-induced sweating syndrome (CS/CISS) is an autosomal recessive disease characterized by hyperthermia, camptodactyly, feeding and respiratory difficulties often leading to sudden death in the neonatal period. The affected individuals who survived the first critical years of life, develop cold-induced sweating and scoliosis in early childhood. The disease is caused by variants in the CRLF1 or in the CLCF1 gene. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.13639
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http://dx.doi.org/10.1111/cge.13639DOI Listing
January 2020
3 Reads

Variable clinical features and genotype-phenotype correlations in 18 patients with late-onset Pompe disease.

Ann Transl Med 2019 Jul;7(13):276

Division of Genetics, Department of Pediatrics, University of California- Irvine, Orange, CA, USA.

Background: Pompe disease is a lysosomal storage disorder caused by the deficiency of enzyme acid alpha-glucosidase () which results in accumulation of glycogen, particularly in the skeletal, cardiac, and smooth muscles. The late-onset form with symptoms presenting in childhood through adulthood, is characterized by proximal muscle weakness, respiratory insufficiency, and unlike the infantile-onset form often with no cardiac involvement.

Methods: We report our experience with 18 adult patients (14 males/4 females) with Pompe disease, several of whom had unique findings and novel pathogenic variants. Read More

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http://dx.doi.org/10.21037/atm.2019.06.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642945PMC
July 2019
3 Reads

In Patients with Early-Onset Scoliosis, Can Growing Rods Be Removed Without Further Instrumentation? An Evidenced-Based Review.

HSS J 2019 Jul 27;15(2):201-204. Epub 2019 Feb 27.

Hospital for Special Surgery New York, 535 E 70th St, New York, NY 10021 USA.

Early-onset scoliosis (EOS) is defined by the presence of spinal deformity in children 10 years of age or younger. Left untreated, patients with EOS are at high risk for thoracic insufficiency and early demise. This article provides a critical review of a recent prospective cohort study of children with EOS: "Graduation Protocol After Growing-Rod Treatment: Removal of Implants without New Instrumentation Is Not a Realistic Approach," by Kocyigit and colleagues ( 2017;99(18):1554-1564). Read More

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http://link.springer.com/10.1007/s11420-019-09671-5
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http://dx.doi.org/10.1007/s11420-019-09671-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609653PMC
July 2019
6 Reads

Brace treatment can serve as a time-buying tactic for patients with congenital scoliosis.

J Orthop Surg Res 2019 Jun 27;14(1):194. Epub 2019 Jun 27.

The Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China.

Background: Infantile patients with congenital scoliosis (CS) can be confronted with increasing risk of mortality and morbidity. To date, the effectiveness of conservative treatment in CS has not been sufficiently investigated. We aimed to evaluate the bracing outcome in patients with CS and to investigate whether wearing brace can effectively delay the surgical procedures. Read More

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http://dx.doi.org/10.1186/s13018-019-1244-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598228PMC
June 2019
7 Reads

Prevention of Medical Trauma in Children With Early Onset Scoliosis and the Use of Mehta Casting.

Creat Nurs 2019 May;25(2):103-112

Despite recent emergence of information about treatment of medical trauma in children, the literature remains sparse regarding prevention of medical trauma. Health-care professionals are in an ideal position to educate about and advocate for ways to prevent the far-reaching consequences of medical trauma, yet policies remain which at times contribute to the problem. This article presents practical approaches intended to reduce the likelihood of medical trauma in children receiving serial casting for treatment of progressive infantile scoliosis (PIS). Read More

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http://dx.doi.org/10.1891/1078-4535.25.2.103DOI Listing
May 2019
4 Reads

Prevalence of Hip Dysplasia and Associated Conditions in Children Treated for Idiopathic Early-onset Scoliosis-Don't Just Look at the Spine.

J Pediatr Orthop 2020 Jan;40(1):e49-e52

Shriners Hospitals for Children Salt Lake City.

Background: Hip dysplasia, congenital muscular torticollis, plagiocephaly, and metatarsus adductus are known to be associated. The etiology of infantile idiopathic scoliosis and its association with the aforementioned conditions is unknown. This study reviews a series of infantile scoliosis patients to address this gap. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001390DOI Listing
January 2020
11 Reads

Manual therapy for the pediatric population: a systematic review.

BMC Complement Altern Med 2019 Mar 13;19(1):60. Epub 2019 Mar 13.

Parker University, 2540 Walnut Hill Lane, Dallas, TX, 75229, USA.

Background: This systematic review evaluates the use of manual therapy for clinical conditions in the pediatric population, assesses the methodological quality of the studies found, and synthesizes findings based on health condition. We also assessed the reporting of adverse events within the included studies and compared our conclusions to those of the UK Update report.

Methods: Six databases were searched using the following inclusion criteria: children under the age of 18 years old; treatment using manual therapy; any type of healthcare profession; published between 2001 and March 31, 2018; and English. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2447-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417069PMC
March 2019
43 Reads

Exome sequencing in Crisponi/cold-induced sweating syndrome-like individuals reveals unpredicted alternative diagnoses.

Clin Genet 2019 05 28;95(5):607-614. Epub 2019 Mar 28.

Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.

Crisponi/cold-induced sweating syndrome (CS/CISS) is a rare autosomal recessive disorder characterized by a complex phenotype (hyperthermia and feeding difficulties in the neonatal period, followed by scoliosis and paradoxical sweating induced by cold since early childhood) and a high neonatal lethality. CS/CISS is a genetically heterogeneous disorder caused by mutations in CRLF1 (CS/CISS1), CLCF1 (CS/CISS2) and KLHL7 (CS/CISS-like). Here, a whole exome sequencing approach in individuals with CS/CISS-like phenotype with unknown molecular defect revealed unpredicted alternative diagnoses. Read More

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http://doi.wiley.com/10.1111/cge.13532
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http://dx.doi.org/10.1111/cge.13532DOI Listing
May 2019
41 Reads

Early progression of Krabbe disease in patients with symptom onset between 0 and 5 months.

Orphanet J Rare Dis 2019 02 18;14(1):46. Epub 2019 Feb 18.

Program for the Study of Neurodevelopment in Rare Disorders and Center for Rare Disease Therapy, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA, 15144, USA.

Background: Krabbe disease is a rare neurological disorder caused by a deficiency in the lysosomal enzyme, β-galactocerebrosidase, resulting in demyelination of the central and peripheral nervous systems. If left without treatment, Krabbe disease results in progressive neurodegeneration with reduced quality of life and early death. The purpose of this prospective study was to describe the natural progression of early onset Krabbe disease in a large cohort of patients. Read More

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http://dx.doi.org/10.1186/s13023-019-1018-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378723PMC
February 2019
13 Reads

Pedicle stress shielding following growing rod implantation: case report.

J Neurosurg Spine 2019 Feb 1:1-5. Epub 2019 Feb 1.

1Department of Neurosurgery, Shriners Hospitals for Children-Philadelphia, Pennsylvania; and.

Growing rod surgery for skeletally immature patients helps correct severe scoliosis while allowing continued spinal column growth. Previous reports have studied vertebral body changes following growing rod surgery, but there are currently no published reports on alterations in pedicle morphology. Given the potential need for definitive spinal fusion with pedicle screw instrumentation, an awareness of changes in pedicle morphology is critical. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18955DOI Listing
February 2019
7 Reads

Treatment burden and long-term health deficits of patients with low-grade gliomas or glioneuronal tumors diagnosed during the first year of life.

Cancer 2019 04 8;125(7):1163-1175. Epub 2019 Jan 8.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Low-grade gliomas (LGGs) and low-grade glioneuronal tumors (LGGNTs) diagnosed during the first year of life carry unique clinical characteristics and challenges in management. However, data on the treatment burden, outcomes, and morbidities are lacking.

Methods: A retrospective study of LGGs and LGGNTs diagnosed in patients younger than 12 months at St. Read More

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http://dx.doi.org/10.1002/cncr.31918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420385PMC
April 2019
5 Reads
4.889 Impact Factor

The Changing Position of the Center of Mass of the Thorax During Growth in Relation to Pre-existent Vertebral Rotation.

Spine (Phila Pa 1976) 2019 May;44(10):679-684

Department of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Study Design: Cross-sectional.

Objective: The aim of this study was to analyze the thoracic center of mass (COM) position of children at different ages and evaluate its relation with the previously reported pre-existent rotational pattern of the normal spine.

Summary Of Background Data: The normal, nonscoliotic thoracic spine is known to have a rotational pattern that changes direction during growth, a transition from left-sided toward right-sided rotation with increasing age. Read More

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http://dx.doi.org/10.1097/BRS.0000000000002927DOI Listing
May 2019
19 Reads

Serial CAD/CAM Bracing: An Alternative to Serial Casting for Early Onset Scoliosis.

J Pediatr Orthop 2019 Mar;39(3):e185-e189

Department of Orthopedic Surgery, Children's Hospital of Wisconsin, Medical College of Wisconsin; Milwaukee, WI.

Background: Years of casting for infantile scoliosis can lead to significantly detrimental quality of life for both the child and parents. Concerns have been raised about the long-term negative neurodevelopmental effects of repeated anesthesia on young children. We developed an elongation bending derotation brace (EBDB) that uses primarily a bending derotation force applied to the curve to achieve the same goals as the cast. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001287DOI Listing
March 2019
38 Reads

Magnetic Resonance Imaging in Infantile Idiopathic Scoliosis: Is Universal Screening Necessary?

Spine Deform 2018 Nov - Dec;6(6):651-655

Shriners Hospital for Children, 110 Conn Terrace, Lexington, KY 40508, USA.

Study Design: Retrospective chart review.

Objective: Determine if there is a subset of presumed infantile idiopathic scoliosis (IIS) patients who have a low incidence of neural axis abnormalities (NAAs) such that screening magnetic resonance imaging (MRI) may be delayed.

Summary Of Background Data: Individuals with presumed IIS have an increased incidence of NAA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2212134X183007
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http://dx.doi.org/10.1016/j.jspd.2018.04.007DOI Listing
February 2019
39 Reads

Infantile Idiopathic Scoliosis: Factors Affecting EDF Casting Success.

Spine Deform 2018 Sep - Oct;6(5):614-620

Department of Orthopaedic Surgery, Shriner's Hospital for Children Salt Lake City, Fairfax Road & Virginia Street, Salt Lake City, UT 84103, USA.

Study Design: IRB-approved retrospective single cohort study.

Objectives: To review our ten-year history with EDF (Elongation Derotation Flexion) casting in patients with infantile idiopathic scoliosis (IIS) to better understand which factors predict successful outcomes.

Summary Of Background Data: Numerous studies have demonstrated the efficacy of EDF casting in the treatment of progressive infantile idiopathic scoliosis. Read More

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http://dx.doi.org/10.1016/j.jspd.2018.01.007DOI Listing
January 2019
17 Reads

Effect of an elongation bending derotation brace on the infantile or juvenile scoliosis.

Scoliosis Spinal Disord 2018 7;13:13. Epub 2018 Aug 7.

4Division of Biostatistics, Institution for Health & Society, Medical College of Wisconsin, Milwaukee, WI USA.

Background: A wide variety of braces are commercially available designed for the adolescent idiopathic scoliosis (AIS), but very few braces for infantile scoliosis (IS) or juvenile scoliosis (JS). The goals of this study were: 1) to briefly introduce an elongation bending derotation brace (EBDB) in the treatment of IS or JS; 2) to investigate changes of Cobb angles in the AP view of X-ray between in and out of the EBDB at 0, 3, 6, 9, and 12 months; 3) to compare differences of Cobb angles (out of brace) in 3, 6, 9, and12 month with the baseline; 4) to investigate changes (out of brace) in JS and IS groups separately.

Methods: Thirty-eight patients with IS or JS were recruited retrospectively for this study. Read More

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https://scoliosisjournal.biomedcentral.com/articles/10.1186/
Publisher Site
http://dx.doi.org/10.1186/s13013-018-0160-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080392PMC
August 2018
48 Reads

Esophageal perforation caused by a thoracic pedicle screw.

Eur Spine J 2018 May 3. Epub 2018 May 3.

Orthopaedic Pediatric Department, University Hospital of Montpellier, Montpellier, France.

This grand round raises the risk of a rare complication that can be avoided with the knowledge of the particular anatomy of scoliosis vertebra. Transpedicular screws have been reported to enhance the operative correction in scoliosis surgery. The narrow and inconsistent shape of the thoracic pedicles makes the placement of pedicle screws technically challenging. Read More

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http://dx.doi.org/10.1007/s00586-018-5611-3DOI Listing
May 2018
29 Reads

Hormonal, metabolic and skeletal phenotype of Schaaf-Yang syndrome: a comparison to Prader-Willi syndrome.

J Med Genet 2018 05 1;55(5):307-315. Epub 2018 Mar 1.

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA.

Background: Nonsense and frameshift mutations in the maternally imprinted, paternally expressed gene located in the Prader-Willi critical region 15q11-15q13, have been reported to cause Schaaf-Yang syndrome (SYS), a genetic disorder that manifests as developmental delay/intellectual disability, hypotonia, feeding difficulties and autism spectrum disorder. Prader-Willi syndrome (PWS) is a genetic disorder characterised by severe infantile hypotonia, hypogonadotrophic hypogonadism, early childhood onset obesity/hyperphagia, developmental delay/intellectual disability and short stature. Scoliosis and growth hormone insufficiency are also prevalent in PWS. Read More

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http://dx.doi.org/10.1136/jmedgenet-2017-105024DOI Listing
May 2018
27 Reads

The Natural History of Idiopathic Scoliosis During Growth: A Meta-Analysis.

Am J Phys Med Rehabil 2018 05;97(5):346-356

From the ISICO (Italian Scientific Spine Institute), Milan, Italy (FDF, FZ, SD); Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy (SN); and IRCCS Fondazione Don Gnocchi, Milan, Italy (SN).

Objective: The aim of the study was to provide a meta-analysis of current literature concerning the natural history of idiopathic scoliosis during growth.

Design: A comprehensive search of Medline, Embase, And Scopus databases was conducted up to November 2016. Eligible works were prospective or retrospective studies that enrolled patients with infantile idiopathic scoliosis, juvenile idiopathic scoliosis, or adolescent idiopathic scoliosis, followed up without any treatment from the time of detection. Read More

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http://dx.doi.org/10.1097/PHM.0000000000000861DOI Listing
May 2018
10 Reads

Results of Casting in Severe Curves in Infantile Scoliosis.

J Pediatr Orthop 2018 Apr;38(4):e186-e189

Shriners Hospitals for Children, Greenville, SC.

Background: Previous work has demonstrated best results for casting in infantile scoliosis when the curves are small and the child begins casting under 2 years of age. This study examines if casting can delay the need for growth friendly instrumentation in severe curves (50 to 106 degrees) and how the comorbidities of syrinx or genetic syndromes affected outcomes.

Methods: All children undergoing casting for scoliosis at a single institution over an 8-year period were examined. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001140DOI Listing
April 2018
7 Reads

Neuromuscular diseases: Diagnosis and management.

Orthop Traumatol Surg Res 2018 02 28;104(1S):S89-S95. Epub 2017 Nov 28.

Service d'orthopédie et de chirurgie réparatrice de l'enfant, département hospitalo-universitaire maladies musculosquelettiques et innovations thérapeutiques (MAMUTH), hôpital d'enfants Armand-Trousseau, 26, avenue du Dr-A.-Netter, 75571 Paris cedex 12, France.

Neuromuscular diseases (NMDs) affect the peripheral nervous system, which includes the motor neurons and sensory neurons; the muscle itself; or the neuromuscular junction. Thus, the term NMDs encompasses a vast array of different syndromes. Some of these syndromes are of direct relevance to paediatric orthopaedic surgeons, either because the presenting manifestation is a functional sign (e. Read More

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http://dx.doi.org/10.1016/j.otsr.2017.04.019DOI Listing
February 2018
14 Reads

Rapidly increasing incidence in scoliosis surgery over 14 years in a nationwide sample.

Eur Spine J 2018 02 19;27(2):286-292. Epub 2017 Oct 19.

Department of Clinical Science, Intervention and Technology, Division of Orthopedics and Biotechnology, Karolinska Institutet, Karolinska University Hospital, Huddinge, K54, 141 86, Stockholm, Sweden.

Purpose: Severe scoliosis is primarily managed with surgery. This cohort study describes the incidence of surgically treated scoliosis among Swedish youth and young adults, stratified by age, sex, scoliosis type, and surgical approach and identifies changes in incidence rate and hospital length of stay (LOS), infections requiring re-surgery and mortality within 90 days.

Methods: Swedish youth, 0-21 years, (n = 3062) with a diagnostic code for scoliosis and spine surgery between 2000 and 2013 were selected from the National Patient Register. Read More

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http://dx.doi.org/10.1007/s00586-017-5346-6DOI Listing
February 2018
12 Reads

A novel mutation in FGD4 causes Charcot-Marie-Tooth disease type 4H with cranial nerve involvement.

Neuromuscul Disord 2017 Oct 26;27(10):959-961. Epub 2017 Jul 26.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan. Electronic address:

Charcot-Marie-Tooth disease type 4H (CMT4H) is a rare variant of autosomal recessive hereditary neuropathy. It is caused by FGD4 mutations and characterized by early infantile onset, slowly progressive distal muscle weakness, scoliosis, and myelin outfoldings visible in nerve biopsy samples. Here, we report a 65-year-old male born to consanguineous parents, who carries a novel homozygous FGD4 c. Read More

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http://dx.doi.org/10.1016/j.nmd.2017.07.011DOI Listing
October 2017
13 Reads

Progressive Infantile Scoliosis Managed With Osteopathic Manipulative Treatment.

J Am Osteopath Assoc 2017 Sep;117(9):595-599

Infantile idiopathic scoliosis is a compensatory result of cranial and sacral intraosseous dysfunction associated with asymmetric developmental deformation of the occiput, leading to dysfunction of the sphenobasilar synchondrosis. A female infant with progressive infantile idiopathic scoliosis diagnosed at age 12 months (46.9° left scoliotic curve) initially received standard orthopedic care, including casting. Read More

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http://dx.doi.org/10.7556/jaoa.2017.114DOI Listing
September 2017
11 Reads

Initial Cast Correction as a Predictor of Treatment Outcome Success for Infantile Idiopathic Scoliosis.

J Pediatr Orthop 2017 Dec;37(8):e625-e630

*Children's Hospital at Montefiore, Bronx, NY †Boston Children's Hospital, Boston, MA ‡Children's Hospital Colorado, Aurora, CO §Department of Orthopaedic Surgery, University of Rochester, Rochester, NY ∥Cincinnati Children's Hospital, Cincinnati, OH ¶Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, MD #Shriners Hospital for Children, Salt Lake City, UT **Children's Spine Foundation, Valley Forge, PA ††Growing Spine Foundation, Milwaukee, WI.

Background: Cast treatment for infantile idiopathic scoliosis patients ultimately corrects deformity in varying amounts. As the reasons for these differential outcomes are not fully elucidated, the aim of this study was to identify clinical and radiographic variables correlated with better cast correction.

Methods: Patients in the Children's Spine Study Group and Growing Spine Study Group registries who underwent cast treatment for idiopathic scoliosis between 2005 and 2013 with 1-year minimum follow-up were included. Read More

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http://Insights.ovid.com/crossref?an=01241398-201712000-0004
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http://dx.doi.org/10.1097/BPO.0000000000001006DOI Listing
December 2017
93 Reads

A procedure to detect abnormal sensorimotor control in adolescents with idiopathic scoliosis.

Gait Posture 2017 09 4;57:124-129. Epub 2017 Jun 4.

Faculté de médecine, Département de kinésiologie, Université Laval, Québec, Canada; Centre de recherche du CHU de Québec, Québec, Canada. Electronic address:

This work identifies, among adolescents with idiopathic scoliosis, those demonstrating impaired sensorimotor control through a classification procedure comparing the amplitude of their vestibular-evoked postural responses. The sensorimotor control of healthy adolescents (n=17) and adolescents with idiopathic scoliosis (n=52) with either mild (Cobb angle≥15° and ≤30°) or severe (Cobb angle >30°) spine deformation was assessed through galvanic vestibular stimulation. A classification procedure sorted out adolescents with idiopathic scoliosis whether the amplitude of their vestibular-evoked postural response was dissimilar or similar to controls. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2017.05.032DOI Listing
September 2017
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Physical Therapy for a Child With Infantile Idiopathic Scoliosis and Motor Delay.

Pediatr Phys Ther 2017 07;29(3):E1-E6

Department of Pediatrics, JFK Partners (Dr Hall), and Physical Therapy Program, Anschutz Medical Campus (Dr Rapport), University of Colorado School of Medicine, Aurora.

Purpose: The purpose of this case report is to describe physical therapy (PT) for a child with infantile idiopathic scoliosis and motor delay.

Key Points: A 10-month-old boy with a 28° left thoracolumbar scoliosis was referred for PT and was seen weekly in his home over a 6-month period following a diagnosis of scoliosis and delayed gross motor milestones. Before the initiation of PT, the child was scheduled to undergo serial casting for correction of the spinal curve and was not yet rolling or transitioning in or out of sitting. Read More

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http://dx.doi.org/10.1097/PEP.0000000000000389DOI Listing
July 2017
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