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Acta Ortop Mex 2018 May-Jun;32(3):145-156

Servicio de Cirugía Ortopédica y Traumatología. Hospital Clínico Universitario de Valencia. Valencia, España.

Background: To quantify the morphological changes in the surface of the back of adolescents with idiopathic scoliosis as a result of treatment with braces and to correlate them with radiographic changes.

Material And Methods: An analytical, cohort, prospective study on a sample of 31 adolescents with idiopathic scoliosis. We divided them into two groups: eleven treated with braces and twenty without them. Read More

Clin Spine Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedic Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.

Study Design: This is a retrospective case series.

Objective: Define the anatomic variations and the risk factors for such within the operative corridor of the transpsoas lateral interbody fusion.

Summary Of Background Data: The lateral interbody fusion approach has recently been associated with devastating complications such as injury to the lumbosacral plexus, surrounding vasculature, and bowel. Read More

Int J Comput Assist Radiol Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Biomedical Engineering, University of Alberta, 1098 Research Transition Facility, 8308-114 Street, Edmonton, AB, T6G 2V2, Canada.

Purpose: Determine the positional, rotational and reconstruction accuracy of a 3D ultrasound system to be used for image registration in navigation surgery.

Methods: A custom 3D ultrasound for spinal surgery image registration was developed using Optitrack Prime 13-W motion capture cameras and a SonixTablet Ultrasound System. Temporal and spatial calibration was completed to account for time latencies between the two systems and to ensure accurate motion tracking of the ultrasound transducer. Read More

Microsurgery 2018 Dec 3. Epub 2018 Dec 3.

Department of Plastic and Reconstructive Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Reconstruction of complex back defects, especially after corrective spine surgery, is a challenging problem. In these patients hardware issues predominate and flap failure has serious consequences. Certain subunits of the back pose even greater problems, specifically the central region between T9 and T12. Read More

Curr Opin Endocrinol Diabetes Obes 2018 Nov 30. Epub 2018 Nov 30.

Division of Endocrinology and Diabetes, Golisano Children's Hospital, University of Rochester Medical Centre, Rochester, New York, USA.

Purpose Of Review: Glucocorticoid therapy is currently the most widely used treatment for Duchenne muscular dystrophy (DMD), having consistently shown to prolong ambulation by 2 years, reduce the frequency of scoliosis, and improve cardiorespiratory function. Among the most frequent side effects of glucocorticoids are fractures due to osteoporosis, linear growth retardation or arrest, and pubertal delay, the subjects of this review.

Recent Findings: The diagnosis of osteoporosis has shifted in recent years away from a bone mineral density-centric to a fracture-focused approach, with particular emphasis on early vertebral fracture identification (one of the key triggers for osteoporosis intervention). Read More

Clin Spine Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto.

Study Design: Retrospective, single-center, single-surgeon study.

Objective: This study investigated screw perforation rate according to surface registration accuracy in pedicle screw fixation using a CT-based navigation system for adolescent idiopathic scoliosis (AIS).

Summary Of Background Data: Posterior spinal fusion for scoliosis correction using pedicle screws is widely adopted but carries a risk of serious neurovascular or visceral structure events. Read More

Reumatologia 2018 31;56(5):289-293. Epub 2018 Oct 31.

Department of Radiology, San Paolo Hospital, Bari, Italy.

Objectives: The aim of this study was to determine the prevalence of "rheumatic" and "non-rheumatic" changes of the sacro-iliac joints (SIJ).

Material And Methods: We performed MRI in 210 patients with suspected inflammatory low back pain. We sorted and analysed the characteristics of sacroiliac bone lesions in "rheumatic" and "non-rheumatic" patients and assessed the diagnostic values of their extent and location. Read More

Spine J 2018 Nov 29. Epub 2018 Nov 29.

Department of Orthopedic Surgery, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address:

Background Context: - Surgery for adult spinal deformity (ASD) is a challenging and complex procedure with high reported complication (8.4-42%) and revision rates (9-17.6%). Read More

Clin Orthop Relat Res 2018 Nov 13. Epub 2018 Nov 13.

A. Y. L. Wong, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China D. Samartzis, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA P. W. H. Cheung, J. P. Y. Cheung, Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China.

Background: Adolescent idiopathic scoliosis (AIS) is the most common spine deformity in adolescent patients. Although structural deformity may affect spinal biomechanics of patients with AIS, little is known regarding various period prevalence proportions of back pain and chronic back pain and factors associated with back pain in such patients.

Questions/purposes: (1) What are the period prevalence rates of back pain among teenagers with AIS? (2) Is back pain in patients with AIS associated with curve severity?

Methods: A total of 987 patients with AIS who were treated without surgery were recruited from a single center's scoliosis clinic. Read More

J Bone Joint Surg Am 2018 Dec;100(23):2024-2032

Department of Anesthesiology, Critical Care, and Pain Medicine (S.M.G., D.Z., M.E.M., R.M.B., and N.F.S.) and Department of Orthopaedic Surgery (M.P.G., D.H., L.I.K., J.B.E., and M.T.H.), Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Background: Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss. Evidence supporting its efficacy in surgery for adolescent idiopathic scoliosis is not robust. This trial was designed to validate the clinical efficacy of TXA in surgery for adolescent idiopathic scoliosis. Read More

SICOT J 2018 5;4:56. Epub 2018 Dec 5.

Mumbai Spine Scoliosis & Disc Replacement Centre, Bombay Hospital & Medical Research Center, Marine Lines, Mumbai 400002, India.

Introduction: Precise targeted excision of the C5-C6 osteoid osteoma with placement of reference array on clavicle with minimal disturbance of anatomy and motion.

Methods: A 20-year-old male presented with an osteoid osteoma in the superior end plate of the C6 vertebra abutting the spinal canal causing intractable pain. The authors curetted the nidus using a 3D C-arm-based intraoperative scan integrated with an optical navigation system through a minimal access anterior cervical exposure. Read More

Eur Spine J 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.

Purpose: We investigated the involvement of sarcopenia in middle-aged and elderly women with degenerative lumbar scoliosis (DLS).

Methods: A total of 971 women (mean age 70.4 years) were included in our study. Read More

J Orthop Sci 2018 Dec 1. Epub 2018 Dec 1.

Department of Orthopedic Surgery, Shinshu University, School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Background: Reducing the number of screw insertions while maintaining good clinical outcomes can improve the efficiency and cost-effectiveness of scoliosis surgery. However, the optimal minimum number of pedicle screws remains unclear. This study searched for factors to estimate the fewest number of pedicle screws required between end vertebrae in relation to preoperative main thoracic curve flexibility. Read More

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Dec;35(6):844-847

Department of Rheumatology and Immunology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, China.

Objective: To explore the clinical phenotype, genetic variant, treatment and prognosis of a child with mosaic variegated aneuploidy syndrome (MVAS).

Methods: Immunological marker screening, chromosomal karyotyping and whole exome sequencing were carried out.

Results: The 1-year-11-month old girl has featured severe growth retardation, feeding difficulty, short stature, microcephaly, facial anomalies, scoliosis, visual impairment, hypotonia, chylothorax, and renal lesions. Read More

J Orthop Surg Res 2018 Nov 29;13(1):305. Epub 2018 Nov 29.

Department of Orthopaedics, First Hospital of Wuhan, No. 215 Zhongshan Road, Wuhan, 430022, China.

Background: To compare the clinical and radiological outcomes of the surgical correction of Lenke type 1 to 4 scoliosis by using a multilevel Ponte osteotomy procedure with posterior selective segmental pedicle screw constructs or posterior release and selective segmental pedicle screw constructs only in patients with adolescent thoracic idiopathic scoliosis.

Methods: Retrospective analysis of 65 patients, 32 treated with the multilevel Ponte procedure (Group A) and 33 with posterior soft tissue release only (Group B). The groups were compared with regard to the change in spinal alignment from preoperative to postoperative assessment and over the follow-up period. Read More

J Neurosurg Spine 2018 Nov 1:1-11. Epub 2018 Nov 1.

OBJECTIVEFixed sagittal spinal malalignment is a common problem in adult spinal deformity (ASD). Various three-column osteotomy techniques, including the extended pedicle subtraction osteotomy (ePSO), may correct global and regional malalignment in this patient population. In contrast to the number of reports on traditional PSO (Schwab grade 3 osteotomy), there is limited literature on the outcomes of ePSO (Schwab grade 4 osteotomy) in ASD surgery. Read More

J Pediatr Orthop B 2018 Nov 26. Epub 2018 Nov 26.

Department of Orthopaedic Surgery, State University of New York, Downstate Medical Center.

Comparing risks against benefits of adolescent idiopathic scoliosis (AIS) patients participating in sports represents a controversial topic in the literature. Previous studies have reported sports participation as a possible risk factor for AIS development, while others describe its functional benefits for AIS athletes. The objective of this study was to determine if sports participation had an impact on pain, function, mental status, and self-perception of deformity in patients and their parents. Read More

J Neurosurg Spine 2018 Oct 1:1-7. Epub 2018 Oct 1.

OBJECTIVEVenous thromboembolic events (VTEs) are a common cause of morbidity and mortality after spine surgery. Patients admitted to the intensive care unit (ICU) following spine surgery exhibit high-risk clinical characteristics.METHODSThe authors retrospectively analyzed 1269 ICU patients who had undergone spine surgery between January 1, 2009, and May 31, 2015. Read More

J Neurosurg Pediatr 2018 Oct 1:1-8. Epub 2018 Oct 1.

OBJECTIVEAs scoliosis in arthrogryposis multiplex congenita (AMC) is unusual and the number of cases reviewed in previous studies is also relatively small, no previous study exists that has directly compared the results of spinal deformity correction between AMC and adolescent idiopathic scoliosis (AIS) patients. The aim of this study was to compare the radiographic and clinical outcomes of surgical correction of spinal deformity associated with AMC versus AIS.METHODSTwenty-four adolescents with AMC were matched with 48 AIS patients in terms of Cobb angle of main curve, curve pattern, sex, age at surgery, Risser grade, and length of follow-up. Read More

Am J Sports Med 2018 Nov 28:363546518808486. Epub 2018 Nov 28.

Department of Orthopedic Surgery, University of California, San Diego, California, USA.

Background:: First-time patellar dislocation with an associated chondral or osteochondral loose body is typically treated operatively to address the loose fragment. The incidence of recurrent instability in this patient population if the medial patellofemoral ligament (MPFL) is not reconstructed is unknown.

Purpose:: To determine the recurrent instability rate in patients undergoing surgery for patellar instability with chondral or osteochondral loose bodies, as well as to identify and stratify risk factors for recurrent instability. Read More

Eur Spine J 2018 Nov 27. Epub 2018 Nov 27.

Department of Spine Surgery, Centre Medico Chirurgical et de Réadaptation des Massues - Croix Rouge Francaise, 92 rue Edmond Locard, 69322, Lyon Cedex 05, France.

Introduction And Aim: In order to improve surgical planning of sagittal correction in AIS, we proposed a new sagittal classification-Abelin-Genevois et al. Eur Spine J (27(9):2192-2202, 2018. https://doi. Read More

Eur Spine J 2018 Nov 27. Epub 2018 Nov 27.

, Stockholm, Sweden.

Introduction And Purpose: Little information exists on surgical characteristics, complications and outcomes with corrective surgery for rigid cervical kyphosis (CK). To collate the experience of international experts, the CSRS-Europe initiated an international multi-centre retrospective study.

Methods: Included were patients at all ages with rigid CK. Read More

Zhonghua Yi Xue Za Zhi 2018 Nov;98(43):3485-3489

Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

To assess the bio-mechanical properties of paraspinal muscles in adolescent idiopathic scoliosis (AIS). The MyotonPro® device and shear wave elasticity imaging(SWEI) technique were applied to detect the paraspinal muscle tone (F), stiffness (S), relaxation time (R), Deborah number (C) and elasticity (D) of paravertebral muscles on the concave side and convex side of scoliosis curvature at several points: apex of the curve (a), upper (b) and lower (c) limits of the curve in 23 cases of AIS treated from October to December 2017 in Beijing Chaoyang Hospital.Cobb angle of the main curve was measured on the standing anteroposterior whole spine radiograph. Read More

Zhonghua Yi Xue Za Zhi 2018 Nov;98(43):3479-3484

Department of Spinal Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China.

To compare the reliability and repeatability of simplified skeletal maturity scoring (SSMS) and thumb ossification composite index (TOCI) in the assessment of skeletal maturity in adolescent idiopathic scoliosis(AIS) and their clinical utilization. A review was conducted on 500 AIS patients treated between October 2006 and August 2013 in Nanjing Drum Tower Hospital and one follow-up of each patient was randomly selected for this study.Based on SSMS and TOCI, the radiographs of the left palm were assessed by three observers independently with an interval of 2 weeks. Read More

Bone 2018 Nov 24;120:364-370. Epub 2018 Nov 24.

Department of Rehabilitation, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Department of Rehabilitation, Xinhua Hospital (Chongming Branch), Shanghai Jiao Tong University School of Medicine, Shanghai 202150, China. Electronic address:

The etiology of adolescent idiopathic scoliosis (AIS), the most common rotational deformity of the spine, is still unclear. Emerging evidence suggests that gut microbiota dysbiosis influences musculoskeletal diseases such as arthritis and osteoporosis. However, the alterations of the fecal microbiome in AIS remain unknown. Read More

Chiropr Man Therap 2018 21;26:48. Epub 2018 Nov 21.

1Department of Chiropractic, Faculty of Science and Engineering, Macquarie University, Sydney, Australia.

The use of routine spinal X-rays within chiropractic has a contentious history. Elements of the profession advocate for the need for routine spinal X-rays to improve patient management, whereas other chiropractors advocate using spinal X-rays only when endorsed by current imaging guidelines. This review aims to summarise the current evidence for the use of spinal X-ray in chiropractic practice, with consideration of the related risks and benefits. Read More

Orthop Clin North Am 2019 Jan;50(1):57-76

Division of Orthopaedic Surgery, IWK Health Centre, PO Box 9700, 5850 University Avenue, Halifax, Nova Scotia, B3K-6R8 Canada. Electronic address:

Spinal fusion in young children for treatment of early onset scoliosis is not optimal because it limits growth and contributes to long-term lung compromise. Various types of growth-friendly spinal implants and newer technologies have been introduced in the past few years. Similarly, in adolescent idiopathic scoliosis, fusion decreases spinal mobility and may lead to development of adjacent level disc degeneration. Read More

Spine (Phila Pa 1976) 2018 Nov 20. Epub 2018 Nov 20.

Department of Orthopaedic Surgery (NOCERAL), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Study Design: Retrospective study of a prospectively-collected data.

Objective: To determine whether the severity of the curve magnitude in Lenke 1 and 2 adolescent idiopathic scoliosis (AIS) patients affects the distance and position of the aorta from the vertebra.

Summary Of Background Data: There were studies that looked into the position of the aorta in scoliotic patients but none of them documented the change in distance of the aorta to the vertebra in relation to the magnitude of the scoliosis. Read More

Spine (Phila Pa 1976) 2018 Nov 20. Epub 2018 Nov 20.

Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School.

Study Design: Retrospective study.

Objective: To compare the long-term outcomes of correction surgery for Lenke 1 A/B scoliosis among those with symmetric fusion (SF), upper-dominant fusion (UF) and lower-dominant fusion (LF) in adolescent idiopathic scoliosis (AIS).

Summary Of Background Data: Symmetric fusion, defined as equal number of vertebral levels included in instrumented fusion above and below the apical vertebra or disc of the primary curve, was a new concept raised in AIS selective fusion. Read More

Spine (Phila Pa 1976) 2018 Nov 20. Epub 2018 Nov 20.

Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD.

Study Design: Cost utility analysis OBJECTIVE.: To compare the cost utility of operative vs. nonoperative treatment of adolescent idiopathic scoliosis (AIS) and identity factors that influence cost-utility estimates. Read More

Spine (Phila Pa 1976) 2018 Nov 20. Epub 2018 Nov 20.

Department of Orthopaedics and Traumatology, Hacettepe University School of Medicine, Ankara.

Study Design: Cross-sectional case-control study.

Objective: Compare psychosocial profile of magnetically-controlled growing rod (MCGR) patients to traditional-growing rod (TGR) with an array of psychiatric tools, expecting improvement in MCGR due to decreased number of surgical procedures.

Summary Of Background Data: TGR treatment has had positive clinical and radiographic results; however, upwards of 10 surgical sessions and high complication rates have called into question the quality of life of these children. Read More

Spine (Phila Pa 1976) 2018 Nov 20. Epub 2018 Nov 20.

Spinal Deformity Service, Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.

Study Design: Retrospective cohort of pediatric patients (
Objective: To compare patients who underwent single versus. multi-level VCR surgery in terms of radiographic correction and perioperative complications. Read More

J Pediatr Orthop 2018 Nov 20. Epub 2018 Nov 20.

Department of Orthopaedic Surgery, Shriner's Hospital for Children, Portland, OR.

Background: Correction of severe scoliosis through distraction-based techniques poses a challenge. Magnetically controlled growing rod (MCGR) hardware complications are common with a 27.8% to 46. Read More

Dev Med Child Neurol 2018 Nov 26. Epub 2018 Nov 26.

IRCCS Fondazione Don Carlo Gnocchi, Milano, Italy.

Aim: To describe a new clinical tool, the Rett Syndrome Motor Evaluation Scale (RESMES) and to assess (loco-)motor function in people with Rett syndrome (RTT).

Method: Formal assessment provided by physicians was followed by parents' direct observation at home using the RESMES. Sixty females (mean [SD] age 12y 5mo [8y 9mo], range 3-40y) with a clinical diagnosis and genetically determined RTT participated in the study. Read More

Rev Pneumol Clin 2018 Dec 22;74(6):467-482. Epub 2018 Nov 22.

Service de pédiatrie et CRCM, pôle médicochirurgical de pédiatrie, CHU de Strasbourg, hôpital de Hautepierre, Strasbourg, France.

Introduction: Recent advances in prenatal diagnosis, high frequency oscillatory ventilation and pulmonary arterial hypertension (PAH) therapies have progressively improved the survival of patients with congenital diaphragmatic hernia (CDH). However, CDH is associated with high morbidity that affects about half of surviving children. The main sequelae observed are respiratory (asthma, persistent PAH [PPAH], bronchopulmonary dysplasia, respiratory infections) and digestive (gastroesophageal reflux disease [GERD]). Read More

Asian Spine J 2018 Nov 27. Epub 2018 Nov 27.

Department of Radiodiagnosis, Stanley Medical College, Chennai, India.

Study Design: Retrospective single institutional observational study.

Purpose: Segmental spinal dysgenesis (SSD), a complex spinal dysraphic state caused by notochord malformation disorders, is named after its morphological presentation where a spine segment is dysgenetic, malformed or absent. This study's objective was to examine and reassess SSD imaging findings and correlate them with an embryological explanation. Read More

Asian Spine J 2018 Nov 27. Epub 2018 Nov 27.

Department of Orthopaedic Surgery, National Orthopaedic Centre of Excellence for Research and Learning, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Study Design: Prospective study.

Purpose: To compare patients' and parents' perceptions of physical attributes (PAs) of adolescent idiopathic scoliosis (AIS) patients and to report any correlations between their perceptions and Scoliosis Research Society-22r (SRS-22r) scores.

Overview Of Literature: Few studies have looked into the differences between patients' and parents' perceptions of their appearance. Read More

Arch Dis Child 2018 Nov 24. Epub 2018 Nov 24.

National Centre for Paediatric Rheumatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.

Background: Musculoskeletal complications of Down syndrome (DS) are common but infrequently reported. The combination of ligamentous laxity and low muscle tone contributes to increased risk of a number of musculoskeletal disorders and a delay in acquisition of motor milestones. The primary aim of this study was to describe musculoskeletal anomalies reported in a national cohort of children with DS. Read More

Eur J Med Genet 2018 Nov 23. Epub 2018 Nov 23.

Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, TU Dresden, Germany. Electronic address:

Expression of the fusion genes is considered to be an important mechanism of tumorigenesis. However it is hardly ever discussed in relation to the neurodevelopmental disorders. Here we report on an 18-years-old female patient with 13. Read More

J Orthop Sci 2018 Nov 21. Epub 2018 Nov 21.

Department of Orthopedic Surgery, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.

Background: Spinal sagittal malalignment is managed by long spinal fusion including the pelvis, which reduces lumbar spine range of motion and impairs the activities of daily living. This study aimed to evaluate the changes in activities of daily living after long spinal fusion in adults with spinal deformity, and clarify the improvement or deterioration in the specific activities of daily living postoperatively.

Methods: We retrospectively reviewed 40 adults who underwent long spinal fusion in a single institution between 2014 and 2016 (female/male, 39/1; mean age, 68. Read More

Clin Anat 2018 Nov 24. Epub 2018 Nov 24.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.

Introduction: Anterior column release is a powerful surgical technique for achieving spinopelvic balance in adult patients with sagittal plane deformities. We present an alternative strategy for focal deformity correction from a posterior-only approach. The purpose of this study was to evaluate the feasibility and efficacy of a novel surgical technique called posterior open-wedge diskectomy and anterior longitudinal ligament (ALL) release (POWAR). Read More

Int J Environ Res Public Health 2018 Nov 22;15(12). Epub 2018 Nov 22.

Department of Professional Therapy, Graduate School of Professional Therapy, Gachon University, Gyeonggi-do 13120, Korea.

The prevalence of scoliosis in Korean elementary school students is increasing, leading to various physical and psychological problems. This study aimed to investigate the association between low body weight and scoliosis among Korean elementary school students. This was a cross-sectional analysis. Read More

Med Eng Phys 2018 Nov 19. Epub 2018 Nov 19.

Paediatric Spine Research Group, Institute of Health and Biomedical Innovation at Centre for Children's Health Research, Queensland University of Technology, Brisbane, Australia. Electronic address:

Externally visible deformities are cosmetic features of great concern for Adolescent Idiopathic Scoliosis (AIS) patients. Current assessment techniques for AIS do not fully encompass the external deformity. A non-invasive method capable of capturing superficial anatomy, such as 3D scanning, would enable better qualitative and quantitative evaluation of cosmesis. Read More

Clin Biomech (Bristol, Avon) 2018 Nov 7;61:46-51. Epub 2018 Nov 7.

Department of Kinesiology, University of Georgia, Athens, GA, USA.

Background: The purpose of the study was to assess the postural stability and complexity of postural control for moderately physically active individuals with spinal fusion for adolescent idiopathic scoliosis at two years post-operation.

Methods: Limit of stability test and sensory organization test were conducted for 10 moderately physically-active participants with spinal fusion and 10 controls pair-matched for mass, height and physical activity level. During the limit of stability test, participants were instructed to lean the center of gravity as far as possible toward 8 predetermined directions and the maximum excursion and direction control were analyzed. Read More

Surg Radiol Anat 2018 Nov 21. Epub 2018 Nov 21.

Department of Anatomy, Mersin University Faculty of Medicine, Ciftlikkoy Campus, 33343, Mersin, Turkey.

The CHARGE syndrome characterized by coloboma, heart defects, atresia of the choanae, retarded growth, genitourinary hypoplasia, and ear anomalies is one of the rare syndromes. Although certain clinical issues (scapular winging, sloping shoulder, Sprengel's deformity, kyphosis and scoliosis) which could be related to abnormalities in musculoskeletal structures of the neck and shoulder have been identified in CHARGE syndrome, data on details of muscle anomalies seem to be quite limited in the literature. In this case report, bilateral multiple muscular abnormalities (agenesis of the trapezius, presence of the rhombo-atloid muscle, and presence of the bipartite rhomboid minor with superficial and deep parts) was presented in a fetus cadaver with atypical CHARGE syndrome to attract the attention of clinicians for definitive diagnoses and surgical reconstruction of the shoulders deformity such as scapular winging and Sprengel's deformity. Read More

Cell Death Differ 2018 Nov 21. Epub 2018 Nov 21.

Department of Orthopedics, Peking Union Medical College Hospital, Beijing, P.R. China.

Adolescent idiopathic scoliosis (AIS) is a complex, three dimensional deformity of the spine that commonly occurs in pubescent girls. Abnormal osteogenic differentiation of mesenchymal stem cells (MSCs) is implicated in the pathogenesis of AIS. However, the biological roles of long noncoding RNAs (lncRNAs) in the regulation of osteogenic differentiation of MSCs are unknown. Read More

Am J Med Genet A 2018 Nov 21. Epub 2018 Nov 21.

Research and Knowledge Center in Sensory Genetics, Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark.

TARP syndrome (talipes equinovarus, atrial septal defect, Robin sequence, and persistence of the left superior vena cava) is a rare X-linked syndrome often resulting in pre- or post-natal lethality in affected males. In 2010, RBM10 was identified as the disease-causing gene, and we describe the first adult patient with TARP syndrome at age 28 years, hereby expanding the phenotypic spectrum. Our patient had Robin sequence, atrial septal defect, intellectual disability, scoliosis, and other findings previously associated with TARP syndrome. Read More

Curr Opin Pediatr 2018 Nov 15. Epub 2018 Nov 15.

Orthopedic Surgery Department, Hotel-Dieu de France Hospital, Saint-Joseph University, Achrafieh, Beirut, Lebanon.

Purpose Of Review: Provide primary care physicians with the best available evidence to support answers to frequently asked questions by caregivers of patients with adolescent idiopathic scoliosis (AIS).

Recent Findings: A review of best available evidence shows that schoolbag design and weight are not associated with higher odds of developing AIS. However, patients with AIS are more prone to balance problems with asymmetric backpack carrying and with rising weights. Read More