Search Our Scientific Publications & Authors

BMC Musculoskelet Disord 2022 Jun 24;23(1):610. Epub 2022 Jun 24.

Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Background: Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity that predominantly occurs in girls. While skeletal growth and maturation influence the development of AIS, accurate prediction of curve progression remains difficult because the prognosis for deformity differs among individuals. The purpose of this study is to develop a new diagnostic platform using a deep convolutional neural network (DCNN) that can predict the risk of scoliosis progression in patients with AIS. Read More

Children (Basel) 2022 Jun 17;9(6). Epub 2022 Jun 17.

Paediatric Orthopaedic Unit, Lenval Foundation, 57, Avenue de la Californie, 06200 Nice, France.

Background: The results of 12 h nighttime Cheneau-Toulouse-Munster (CTM) brace wear on adolescent idiopathic scoliosis are poorly described.

Objective: The main objective was to analyze the efficiency of 12 h nighttime CTM brace wear on adolescent idiopathic scoliosis. The secondary objective was to identify the factors influencing good results. Read More

Children (Basel) 2022 Jun 11;9(6). Epub 2022 Jun 11.

ISICO (Italian Scientific Spine Institute), 20141 Milan, Italy.

We introduced pelvis semi-rigid material (ethylene vinyl acetate) (Free-Pelvis) to improve the comfort and adaptability of very rigid braces (VRBs) for adolescents with idiopathic scoliosis (AIS), but this can also negatively impact the corrective forces on the trunk. Study Design: This was a matched retrospective cohort study. The inclusion criteria were AIS, age 10-16, VRB 23 h/day, X-rays available, primary curve 36°-65°, and angle of trunk rotation 7-23°. Read More

Children (Basel) 2022 Jun 7;9(6). Epub 2022 Jun 7.

Boston Orthotics & Prosthetics, Avon, MA 02322, USA.

Background: Adolescent idiopathic scoliosis (AIS) is characterized by a lateral curvature of the spine with a Cobb angle greater than 10 degrees, accompanied by rotation of the vertebral body. Bracing has been shown to be effective in halting the progression of at-risk curves, and, in some cases, even improving the Cobb angle by 6° or more. The Boston Brace 3D is part of the Boston Orthotics and Prosthetics standardized scoliosis program. Read More

Spine Deform 2022 Jun 23. Epub 2022 Jun 23.

DePuy Synthes Spine, Johnson & Johnson Medical Devices, 325 Paramount Drive, Raynham, MA, 02767, USA.

Purpose: To assess surgical and safety outcomes associated with different rod materials and diameters in adolescent idiopathic scoliosis (AIS) surgery.

Methods: A systematic literature review and meta-analysis evaluated the surgical management of AIS patients using pedicle screw fixation systems (i.e. Read More

Bioengineering (Basel) 2022 May 27;9(6). Epub 2022 May 27.

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR 999077, China.

The Schroth exercise can train the paraspinal muscles of patients with adolescent idiopathic scoliosis (AIS), however, muscle performance during the training remains unknown. This study applied surface electromyography (sEMG) to investigate the paraspinal muscle activities before, during and after Schroth exercise in nine AIS patients. This study found that after the Schroth exercise, the paraspinal muscle symmetry index (PMSI) was significantly reduced (PMSI = 1. Read More

BMC Musculoskelet Disord 2022 Jun 22;23(1):602. Epub 2022 Jun 22.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: To evaluate the incidence and risk factors of postoperative distal adding-on in patients with Lenke 5C adolescent idiopathic scoliosis (AIS). More accurate selection criteria for the lower instrumented vertebra (LIV) should be confirmed to prevent distal adding-on.

Methods: Forty-six patients with Lenke 5C AIS who underwent posterior fusion were enrolled in the study. Read More

Spine Deform 2022 Jun 23. Epub 2022 Jun 23.

Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, 1450 San Pablo St., HC4, Suite 5400A, Los Angeles, CA, 90003, USA.

Purpose: The aim of the current review is to summarize the current evidence on graft materials used in fusion procedures for spinal deformity corrections.

Methods: PubMed, Embase, and Cochrane Library were searched for relevant published observational studies and clinical trials using osteobiologics and biomaterials in spinal deformity surgery.

Results: The use of autograft in deformity correction surgeries has been reported in a limited number of studies, with the harvest sites including iliac crest, ribs, and local bone. Read More

Spine Deform 2022 Jun 20. Epub 2022 Jun 20.

Department of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Via Giulio Cesare Pupilli 1, 40136, Bologna, Italy.

Purpose: To retrospectively evaluate a cohort of athletically active patients who underwent surgery for adolescent idiopathic scoliosis (AIS), and to determine which clinical, surgical and anthropometric variables influenced their return to sport after surgery.

Methods: 112 adolescents who underwent high-density posterior fusion for AIS by a single surgeon were analyzed for clinical, surgical and demographic predictors of return to presurgical physical activity levels. Data were retrospectively collected by charts and X-rays analysis and patients interviews. Read More

J Back Musculoskelet Rehabil 2022 Jun 7. Epub 2022 Jun 7.

Verom Spine and Tumor Center, Bursa, Turkey.

Background: To date, only one study assessed the spinal mobility and muscle strength of patients who were treated either with fusion or brace treatment.

Objective: The aim of this retrospective study was to evaluate the range of motion (ROM) and strength of the cervical and thoracic/lumbar spine in patients who underwent spinal fusion for the treatment of adolescent idiopathic scoliosis (AIS) in comparison to healthy individuals.

Methods: Patients (n= 28) who were treated surgically for AIS were included in the study. Read More

Orthop Traumatol Surg Res 2022 Jun 15:103350. Epub 2022 Jun 15.

Department of Pediatric Orthopedic, Armand Trousseau Hospital, Paris 6 University, France.

Background: Determining which spinal levels to instrument during surgical treatment of Lenke Type 1 adolescent idiopathic scoliosis (AIS) depends on the reducibility of the primary and secondary curve patterns. This reducibility can be evaluated in several ways, with the most popular being radiographs in bending for moderate thoracic and lumbar curvatures.

Hypothesis: Side-bending radiographs will alter the choice of the lowest instrumented vertebra (LIV) for the surgical treatment of AIS. Read More

Orthop Traumatol Surg Res 2022 Jun 14:103352. Epub 2022 Jun 14.

Department of Radiology, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang, Hebei Province, 050051, China.

Introduction: Surgery for patients with adolescent idiopathic scoliosis (AIS) may change spinal sagittal alignment, and postoperative adding-on may affect spinal sagittal balance after reconstruction. This study was to investigate the effect of surgery on spinal sagittal alignment and the relationship between postoperative adding-on and spinal sagittal balance in patients with AIS.

Hypothesis: The hypothesis of this study was that the effect of surgery on AIS was associated with recovery of the spinal sagittal plane and that presence of postoperative adding-on might affect the spinal sagittal balance. Read More

Comput Math Methods Med 2022 6;2022:3796202. Epub 2022 Jun 6.

Department of Medical Examination Center, Huaqiao University Affiliated Strait Hospital, Quanzhou, Fujian 362000, China.

In order to reduce the subjectivity of preoperative diagnosis and achieve accurate and rapid classification of idiopathic scoliosis and thereby improving the standardization and automation of spinal surgery diagnosis, we implement the Faster R-CNN and ResNet to classify patient spine images. In this paper, the images are based on spine X-ray imaging obtained by our radiology department. We compared the results with the orthopedic surgeon's measurement results for verification and analysis and finally presented the grading results for performance evaluation. Read More

J Pediatr Orthop 2022 Jun 15. Epub 2022 Jun 15.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA.

Background: The use of patient-reported outcome measures, especially Patient-Reported Outcomes Measurement Information System (PROMIS) measures, has increased in recent years. Given this growth, it is imperative to ensure that the measures being used are validated for the intended population(s)/disease(s). Our objective was to assess the construct validity of 8 PROMIS computer adaptive testing (CAT) measures among children with adolescent idiopathic scoliosis (AIS). Read More

Hong Kong Med J 2022 Jun;28 Suppl 3(3):31-33

SH Ho Scoliosis Research Lab, Joint Scoliosis Research Centre of the Chinese University of Hong Kong and Nanjing University, The Chinese University of Hong Kong.

Clin Spine Surg 2022 Jun 13. Epub 2022 Jun 13.

Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, VA.

Study Design: Review of health care record database and determination of population statistics.

Objective: The purpose of this study was to quantify the incidence of clinically significant venous thromboembolic (VTE) events in patients undergoing spinal fusion surgery for adolescent idiopathic scoliosis (AIS) and to identify risk factors for VTE.

Summary Of Background Data: VTE is a serious complication that can cause disability and even death following surgery. Read More

Spine Deform 2022 Jun 13. Epub 2022 Jun 13.

University of Kansas Medical Center, Kansas City, KS, USA.

Study Design: Retrospective case series.

Purpose: To characterize the indications and timing of revision spine surgery in adulthood after adolescent surgery for idiopathic scoliosis. Previous studies have shown that revision usually occurs within 3 months or more than 5 years after the index operation. Read More

Eur Spine J 2022 Jun 13. Epub 2022 Jun 13.

Kobe Medical Center, Suma Ward, Nishiochiai, 3 Chome-1-1, Kobe, Hyogo, 654-0155, Japan.

Purpose: The SHILLA™ Growth Guidance system is a stainless-steel rod and screw system used for Early Onset Scoliosis which incorporates a unique flanged set screw designed to capture the rod, while allowing it to slide as the patient grows. Concomitant with this design is the potential for generation of wear debris and for an inflammatory host response. We hypothesized that the magnitude of the host response adjacent to the unlocked screws and rods would be greater than the host response to the locked rod/screws. Read More

JBJS Essent Surg Tech 2022 Jan-Mar;12(1). Epub 2022 Feb 16.

Department of Advanced Medicine for Spine and Spinal Cord Disorders, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Recent surgical techniques involve 3-dimensional (3D) deformity correction of adolescent idiopathic scoliosis (AIS). However, next-generation surgical strategies should ensure that the final corrected spine is not only "non-scoliotic," but has an anatomically correct shape. We developed a 4D anatomical spinal reconstruction technique that involves the use of spatiotemporal deformity prediction to preoperatively calculate the postoperative apex of thoracic kyphosis in order to achieve an anatomically correct spinal curvature. Read More

Sci Rep 2022 Jun 11;12(1):9705. Epub 2022 Jun 11.

Department of Orthopaedics and Traumatology, SH Ho Scoliosis Research Laboratory, Joint Scoliosis Research Centre of the Chinese University of Hong Kong and Nanjing University, The Chinese University of Hong Kong, Hong Kong SAR, China.

Bone densitometry revealed low bone mass in patients with adolescent idiopathic scoliosis (AIS) and its prognostic potential to predict curve progression. Recent studies showed differential circulating miRNAs in AIS but their diagnostic potential and links to low bone mass have not been well-documented. The present study aimed to compare miRNA profiles in bone tissues collected from AIS and non-scoliotic subjects, and to explore if the selected miRNA candidates could be useful diagnostic biomarkers for AIS. Read More

Musculoskelet Sci Pract 2022 Jun 2;61:102595. Epub 2022 Jun 2.

Department of Chiropractic, Université du Québec à Trois-Rivières, 3351 Boul. des Forges, Trois-Rivières, Québec, G8Z 4M3, Canada; Center for Interdisciplinary Research in Rehabilitation and Social Integration (Cirris), Centre Intégré Universitaire de Santé et de Services Sociaux de La Capitale-Nationale (CIUSSS-CN), 525 Boul. Wilfrid Hamel, Quebec City, Quebec, G1M 2S8, Canada. Electronic address:

Background: Adolescent Idiopathic Scoliosis (AIS) is a three-dimensional deformity of the spine associated with pain and aesthetic changes. Various health care professionals may be led to evaluate and/or manage adolescents presenting AIS. There is no compiling of the studies evaluating the level of knowledge on AIS conservative management among undergraduate students in healthcare. Read More

Orthop Surg 2022 Jun 10. Epub 2022 Jun 10.

Department of Orthopaedics, The 2nd Affiliated Hospital of Kunming Medical University, Kunming, China.

Objective: To investigate the incidence and risk factors of postoperative respiratory complications (PRCs) in children with early-onset scoliosis (EOS) following posterior spine deformity surgery (PSDS) based on growth-friendly techniques, so as to help improve the safety of surgery.

Methods: A retrospective study of children with EOS admitted for PSDS based on growth-friendly techniques from October 2013 to October 2018 was reviewed at a single center. There were 73 children (30 boys, 43 girls) who fulfilled the criteria in this research. Read More

J Clin Med 2022 Jun 2;11(11). Epub 2022 Jun 2.

Department of Orthopaedic Surgery, Mount Sinai Hospital, New York, NY 10029, USA.

Vertebral Body Tethering (VBT) is a non-fusion surgical treatment for Adolescent Idiopathic Scoliosis (AIS) that elicits correction via growth modulation in skeletally immature patients. VBT after peak height velocity is controversial and is the subject of this study. A retrospective review of Risser 3-5 AIS patients treated with VBT, and min. Read More

Int J Mol Sci 2022 May 25;23(11). Epub 2022 May 25.

Department of Biomedical and Neuromotor Science-DIBINEM, 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, University of Bologna, Via Giulio Cesare Pupilli 1, 40136 Bologna, Italy.

Adolescent idiopathic scoliosis (AIS) is a progressive deformity of the spine. Scoliotic curves progress until skeletal maturity leading, in rare cases, to a severe deformity. While the Cobb angle is a straightforward tool in initial curve magnitude measurement, assessing the risk of curve progression at the time of diagnosis may be more challenging. Read More

Syst Rev 2022 06 9;11(1):118. Epub 2022 Jun 9.

Department of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Background: Adolescent idiopathic scoliosis (AIS) is a structural lateral spinal curvature of ≥ 10° with rotation. Approximately 2-3% of children in most populations are affected with AIS, and this condition is responsible for approximately $1.1 billion in surgical costs to the US healthcare system. Read More

Biomed Res Int 2022 27;2022:9305190. Epub 2022 May 27.

Department of Spine Surgery, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang 050051, China.

Objectives: To investigate the risk factors of total blood loss (TBL) and hidden blood loss (HBL) in adolescent idiopathic scoliosis (AIS) patients undergoing posterior orthopedic surgery.

Methods: The AIS patients who visited department of spine surgery between January 2015 and December 2020 were retrospectively reviewed. Those with a history of posterior orthopedic surgery for AIS were identified, and their clinical data were collected. Read More

J Pediatr Orthop 2022 Jul 22;42(6):e559-e564. Epub 2022 Mar 22.

Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA.

Background: Clinical and administrative registries provide large volumes of data that can be used for clinical research. However, there are several limitations relating to the quality, consistency, and generalizability of big data. In this study, we aim to compare reported demographics and certain outcomes in patients undergoing posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS), neuromuscular scoliosis (NS), and Scheuermann kyphosis (SK) between 3 commonly utilized databases in pediatric orthopaedic research. Read More

J Neurosurg Spine 2021 Jul 30;35(4):471-485. Epub 2021 Jul 30.

Istanbul Spine Center, Istanbul Florence Nightingale Hospital, Istanbul, Turkey.

Objective: In double and triple major adolescent idiopathic scoliosis curves it is still controversial whether the lowest instrumented vertebra (LIV) should be L3 or L4. Too short a fusion can impede postoperative distal curve compensation and promote adding on (AON). Longer fusions lower the chance of compensation by alignment changes of the lumbosacral curve (LSC). Read More

Quant Imaging Med Surg 2022 Jun;12(6):3049-3060

Department of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.

Background: To investigate the relationship between sagittal alignment and coronal deformity in patients with adolescent idiopathic scoliosis (AIS) through analysis of the spinal imaging data.

Methods: Four hundred and fifty-four AIS patients who underwent anteroposterior and lateral radiography of the while spine were enrolled, and the spinal parameters of Cobb angle, cervical lordosis, C1-C2 angle, T1 slope, thoracic kyphosis, lumbar lordosis, sacral slope, pelvic tilt (PT), pelvic incidence (PI), cervical sagittal vertical axis (SVA), and spinal SVA were analyzed.

Results: The patients were divided into two groups according to the size of the Cobb angle: group A (Cobb angle ≤45°, n=414) and group B (Cobb angle >45°, n=40). Read More

Quant Imaging Med Surg 2022 Jun;12(6):3325-3339

Department of Imaging and Interventional Radiology, Faculty of Medicine, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

Background: Adolescent idiopathic scoliosis (AIS) patients suffer from restrictive impairment of pulmonary function (PF) as a consequence of spinal and ribcage deformity. Statistic modelling of scoliotic geometry has been well-established based on low-dose biplanar X-ray device (EOS) imaging. However, the postoperative lung morphology change derived from EOS has not yet been studied adequately till now. Read More