199 results match your criteria Sclerema Neonatorum

[Neonatal cytosteatonecrosis complicated by major hypercalcemia].

Pan Afr Med J 2018 30;29:86. Epub 2018 Jan 30.

Laboratoire de Biochimie, CHU Ibn Rochd, Université Hassan II, Casablanca, Maroc.

We here report the case of a female infant with perinatal asphyxia requiring resuscitation. She was referred with sclerema neonatorum which had been observed by parents on her tenth day of life. The lesions appeared as hard erythematous nodular plaques, suggesting neonatal cytosteatonecrosis in the gluteal region. Read More

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June 2018
2 Reads

Sclerema Neonatorum in a Full-Term Infant Showing Favorable Prognosis.

Ann Dermatol 2017 Dec 30;29(6):790-793. Epub 2017 Oct 30.

Department of Dermatology, Gangnam Severance Hospital, Seoul, Korea.

Sclerema neonatorum (SN) is a rare disease characterized by firm, indurated, waxy skin lesions extending throughout the body, sparing the fat-free soles, palms, and genitalia. The prognosis of SN is generally very poor, with a high fatality rate. We report the case of a full-term infant with delayed onset of SN showing good prognosis. Read More

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December 2017

[Vascular anomalies in the neonatal period].

Cir Pediatr 2017 Jul 20;30(3):162-168. Epub 2017 Jul 20.

Servicio de Cirugía Pediátrica. Hospital Sant Joan de Déu. Barcelona.

Objective: Vascular anomalies in the neonatal period are a diagnostic challenge for the lack of evident signs, symptoms and follow-up, and the convenience of restricting aggressive diagnostic tests. The aim of this work is to review the characteristics of neonatal cases presented to our Vascular Anomalies Unit in the last 5 years.

Materials And Methods: All cases of suspected vascular anomaly presented to our unit before 1 month of age between 2010 and 2015 were reviewed, diagnostic tests and treatments carried out with chronology were analyzed. Read More

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July 2017
4 Reads

Sclerema Neonatorum Treated Successfully with Parenteral Steroids: An Experience from a Resource Poor Country.

Case Rep Pediatr 2017 11;2017:4836142. Epub 2017 May 11.

Department of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, Nepal.

Sclerema neonatorum is a form of panniculitides characterized by diffuse hardening of subcutaneous tissue with minimal inflammation. It usually affects ill and preterm neonates. Prognosis is usually poor in many cases despite aggressive management. Read More

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May 2017
5 Reads

Panniculitis: A summary.

Mark R Wick

Semin Diagn Pathol 2017 May 27;34(3):261-272. Epub 2016 Dec 27.

Section of Dermatopathology,Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:

The diagnosis of panniculitis is felt to be a confusing topic by some pathologists. This summarical article presents inflammatory diseases of the subcutis in a systematic fashion, based on whether they are centered on fibrovascular septa or the adipose lobules, and whether morphologic vasculitis is present or not. Septocentric, non-vasculitis disorders include erythema nodosum, panniculitis that follows the use of "biological" therapeutic agents, lipodermatosclerosis, post-irradiation panniculitis, morphea profunda, and necrobiosis lipodica profunda. Read More

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May 2017
2 Reads

Delayed-Onset Sclerema Neonatorum in a Critically Ill Premature Infant.

Pediatr Dermatol 2016 Mar-Apr;33(2):e168-9

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Sclerema neonatorum is extremely rare in the 21st century. We report a premature infant managed in a neonatal intensive care unit with delayed development of sclerema neonatorum. Read More

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January 2017
3 Reads

Panniculitis with crystals induced by etanercept subcutaneous injection.

J Cutan Pathol 2015 Jun 1;42(6):413-5. Epub 2015 Apr 1.

Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain.

Panniculitis with lipid crystallization within adipocytes may be seen in several disorders, including crystal-storing histiocytosis, gouty panniculitis, subcutaneous fat necrosis of the newborn, post-steroid panniculitis, sclerema neonatorum, oxalosis and subcutaneous fungal infections by mucormycosis, zygomycosis or aspergillosis. Panniculitis at the sites of subcutaneous injection of drugs are frequent, but to our knowledge no crystals have been described in the drug-induced panniculitis at the sites of subcutaneous injections. We report on a patient who developed a panniculitis with lipid crystallization at the site of etanercept injection. Read More

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June 2015
2 Reads

Sclerodermatous skin changes in an infant.

Pediatr Dermatol 2014 May-Jun;31(3):387-8

College of Medicine, Medical University of South Carolina, Charleston, South Carolina.

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December 2014
1 Read

Recurrent sclerema in a young infant presenting with severe sepsis and severe pneumonia: an uncommon but extremely life-threatening condition.

J Health Popul Nutr 2013 Dec;31(4):538-42

Clinical Services Centre, icddr,b, GPO Box 128, Dhaka 1000, Bangladesh.

A one month and twenty-five days old baby girl with problems of acute watery diarrhoea, severe dehydration, severe malnutrition, and reduced activity was admitted to the gastrointestinal unit of Dhaka Hospital of icddr,b. The differentials included dehydration, dyselectrolytaemia and severe sepsis. She was treated following the protocolized management guidelines of the hospital. Read More

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December 2013

Sclerema neonatorum treated with intravenous immunoglobulin: a case report and review of treatments.

Cutis 2013 Aug;92(2):83-7

Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Ave S, EFH Set 414, Birmingham, AL 35294-0009, USA.

Sclerema neonatorum (SN) is a rare neonatal panniculitis that typically develops in severely ill, preterm newborns within the first week of life and often is fatal. It usually occurs in preterm newborns with delivery complications such as respiratory distress or maternal complications such as eclampsia. Few clinical trials have been performed to address potential treatments. Read More

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Panniculitis in children.

G Ital Dermatol Venereol 2013 Aug;148(4):371-85

Dipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche, Sezione di Dermatologia Università di Pavia, Fondazione IRCCS Policlinico "San Matteo", Pavia, Italia -

This paper will give a comprehensive view of the most frequent panniculitides seen in childhood, with emphasis on the types exclusively found in infancy, and for all other types of panniculitides also found in adults. Aim of this paper is also to analyze the clinical differences between panniculitis in childhood and in adulthood, and to give reliable histopathologic criteria for a specific diagnosis. A review of the literature is here integrated by authors' personal contribution. Read More

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August 2013
5 Reads

Gemcitabine-associated livedoid thrombotic microangiopathy with associated sclerema neonatorum-like microscopic changes.

J Cutan Pathol 2012 Jul 22;39(7):707-11. Epub 2012 May 22.

Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain.

Gemcitabine is a deoxycytidine analog antimetabolite that is now accepted as first-line treatment for advanced and metastatic pancreatic carcinoma. Gemcitabine-related thrombotic microangiopathy associated with systemic hemolytic-uremic syndrome or thrombotic thrombocytopenia purpura has rarely been described. Herein, we report a patient who developed a livedoid thrombotic microangiopathy with no signs of associated hemolytic-uremic syndrome. Read More

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July 2012
5 Reads

Panniculitis in childhood.

Dermatol Ther 2010 Jul-Aug;23(4):356-67

Section of Dermatology, University of Chicago Medical Center, Chicago, Illinois, USA.

Panniculitis refers to disorders with inflammation of the subcutaneous fat. Such inflammation can be primary or can be a reaction pattern induced by a systemic process. Some types of panniculitis are seen more commonly or exclusively in children. Read More

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November 2010

A firm plaque on the back of a newborn.

Dermatol Online J 2010 Feb 15;16(2):11. Epub 2010 Feb 15.

Department of Dermatology, University of Texas Health Science Center, San Antonio, Texas, USA.

We report a case of subcutaneous fat necrosis of the newborn (SCFN), a rare disorder in term or post-term neonates. Although it is often associated with hematological abnormalities such as anemia and hypercalcemia, SCFN in this patient presented with hyperbilirubinemia. The course of SCFN is generally benign and self-limiting, though may be associated with complications secondary to hypercalcemia. Read More

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February 2010

Risk factors for sclerema neonatorum in preterm neonates in Bangladesh.

Pediatr Infect Dis J 2009 May;28(5):435-8

Department of International Health, International Center for Advancing Neonatal Health, Johns Hopkins University, Baltimore, MD, USA.

Background: This study presents a retrospective analysis of risk factors for sclerema neonatorum in preterm neonates in Bangladesh.

Methods: Preterm neonates admitted to Dhaka Shishu Hospital in Bangladesh were enrolled in a clinical trial to evaluate the effects of topical treatment with skin barrier-enhancing emollients on prevention of sepsis and mortality. Four hundred ninety-seven neonates were enrolled in the study and 51 (10. Read More

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May 2009
4 Reads

Predictors of mortality in infants with sclerema presenting to the Centre for Diarrhoeal Disease, Dhaka.

Ann Trop Paediatr 2009 Mar;29(1):45-50

International Centre for Diarrhoeal Disease Research, Bangladesh, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.

Background: Sclerema is an uncommon, life-threatening condition, usually of newborns, with a case-fatality rate ranging from 50 to 100%. Very little is known about factors influencing outcome.

Aim: To identify clinical and biochemical predictors associated with fatal outcome of sclerema in infants with diarrhoea. Read More

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March 2009
3 Reads

Factors associated with sclerema in infants with diarrhoeal disease: a matched case-control study.

Acta Paediatr 2009 May 9;98(5):873-8. Epub 2009 Jan 9.

International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Aim: To identify clinical and biochemical factors associated with sclerema in infants with diarrhoeal illness, and their outcome.

Methods: In this case-control study, we enrolled 30 infants with clinical sepsis with sclerema (cases) and another 60, age- and sex-matched infants with clinical sepsis but without sclerema (controls) from among those admitted to the special care unit (SCU) and longer stay unit (LSU) of the Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) for their diarrhoeal illness from May 2005 through April 2006. Sclerema as the dependant variable while hypoxia, hypothermia, C-reactive protein (CRP) level, serum total protein and prealbumin level were the major independent variables compared in the analysis. Read More

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May 2009
1 Read

Panniculitis in children.

Dermatol Clin 2008 Oct;26(4):491-500, vii

Department of Dermatology, Hospital del Niño Jesús, C/Menéndez Pelayo 65, 28009 Madrid, Spain.

The panniculitides include a group of disorders of varied etiology that manifest as inflamed nodules in the subcutaneous tissue. They are rarely seen in infants and children. The panniculitides of the newborn represent a unique response of the infant's fat to different injuries, and are a specific type of panniculitis that is only seen in neonates and very young infants. Read More

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October 2008

Cold panniculitis.

Dermatol Clin 2008 Oct;26(4):485-9, vii

Department of Dermatology, Hospital Universitario La Paz, Universidad Autónoma, Paseo La Castellana, No. 261, 28046 Madrid, Spain.

Cold panniculitis has been described in children and young women following cold exposure. Histopathologically, cold panniculitis shows a mostly lobular panniculitis, which consists of an infiltrate of lymphocytes and histiocytes in the fat lobules. Usually, the dermis shows a superficial and deep perivascular infiltrate mostly composed of lymphocytes, with no vasculitis. Read More

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October 2008
2 Reads

Sclerema neonatorum: a review of nomenclature, clinical presentation, histological features, differential diagnoses and management.

A Zeb G L Darmstadt

J Perinatol 2008 Jul 27;28(7):453-60. Epub 2008 Mar 27.

Department of International Health, International Center for Advancing Neonatal Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Objective: To review published literature on sclerema neonatorum (SN) in order to clarify its clinical presentation, histological features and management compared with two other diseases: subcutaneous fat necrosis of the newborn (SCFN) and scleredema.

Study Design: PubMed database was searched using the key words Sclerema neonatorum. A total of 55 articles from peer-reviewed journals were reviewed and summarized. Read More

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Sclerema neonatorum after therapeutic whole-body hypothermia.

Arch Dis Child Fetal Neonatal Ed 2007 Jul;92(4):F307

University Children's Hospital, Basel, Switzerland.

Hypothermia is being studied as a neuroprotective therapy after asphyxia. This report is about a term newborn with severe asphyxia who underwent systemic hypothermia (34.5 degrees C) for 72 h. Read More

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Normal subcutaneous fat, necrosis of adipocytes and classification of the panniculitides.

Luis Requena

Semin Cutan Med Surg 2007 Jun;26(2):66-70

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

The panniculitides represent a group of heterogeneous inflammatory diseases that involve the subcutaneous fat. The specific diagnosis of these diseases requires histopathologic study because different panniculitides usually show the same clinical appearance, which consists of erythematous nodules on the lower extremities. However, the histopathologic study of panniculitis is difficult because of an inadequate clinicopathologic correlation and the changing evolutive nature of the lesions. Read More

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June 2007
2 Reads

[Adiponecrosis subcutanea neonatorum in congenital pneumonia].

Hautarzt 2004 Jan;55(1):67-70

Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany.

In the course of a connatal pneumonia, a 7-day-old female newborn developed symmetrical subcutaneous nodules on her back, shoulders, and upper arms. These skin lesions were accompanied by hypercalcemia. Histological examination confirmed the putative clinical diagnosis of subcutaneous fat necrosis of the newborn. Read More

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January 2004
2 Reads

Sclerema Neonatorum following hypothermia.

J Paediatr Child Health 2002 Oct;38(5):533-4

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October 2002
6 Reads

Panniculitis. Part II. Mostly lobular panniculitis.

J Am Acad Dermatol 2001 Sep;45(3):325-61; quiz 362-4

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Unlabelled: The second part of our review of panniculitis summarizes the clinicopathologic features of the mostly lobular panniculitides. Erythema induratum of Bazin (nodular vasculitis) represents the most common variant of lobular panniculitis with vasculitis, although controversy persists about the nature of the involved vessels. Mostly lobular panniculitides without vasculitis comprise a series of disparate disorders. Read More

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September 2001
3 Reads

[Observation on the changes of lipid peroxidation in neonates with sclerema].

Hua Xi Yi Ke Da Xue Xue Bao 1997 Dec;28(4):440-1

Department of Pediatrics, Second Affiliated Hospital, Chengdu.

Thirty-six hospitalized newborn infants with sclerema (case group), which were divided into mild group(n = 18) and severe group(n = 18), and 28 normal neonates (normal control group) were selected to measure the changes of blood lipid peroxidation (LPO) and superoxide dismutase(SOD) so as to study the role of free radicals and lipid peroxide injury the pathogenesis of the entity. The results showed that the plasma LPO contents were significantly increased and SOD were significantly decreased in the case group when compared with those in the normal group (P < 0.01). Read More

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December 1997

[Dermatoses of the premature child].

J Lacour P Boutté

Ann Dermatol Venereol 1999 Dec;126(12):933-8

Service de Dermatologie, Hôpital de l'Archet-2, BP 3079, 06202 Nice Cedex 3, France.

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December 1999

[Dermatological particularities and pathologies of premature infants].

Rev Med Liege 1999 Oct;54(10):819-22

Service de Dermatologie, Université de Liège.

In contrast with the full-term infant, the skin of the preterm neonate is structurally and functionally immature, especially birth occurred before 30 weeks gestation. The inefficiency of the epidermal barrier may result in dehydration, thermal instability and toxic reactions from percutaneous absorption of topically applied agents. An increased risk for bacteremia and sepsis exist because of the easily injured skin, combined with compromised immunity. Read More

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October 1999

Subcutaneous fat necrosis of the newborn: a review of 11 cases.

Pediatr Dermatol 1999 Sep-Oct;16(5):384-7

Department of Dermatology, Hospital for Sick Children, Toronto, Ontario, Canada.

Subcutaneous fat necrosis (SFN) of the newborn is uncommon and usually occurs in the first weeks of life following a complicated delivery. The frequency with which hypercalcemia develops as a complication is uncertain. We report the clinical features of SFN in 11 patients seen between 1991 and 1998. Read More

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January 2000
4 Reads

Exchange transfusion in septic neonates with sclerema: effect on immunoglobulin and complement levels.

Indian Pediatr 1997 Jan;34(1):20-5

Department of Pediatrics, Maulana Azad Medical College, New Delhi.

Objective: To study the effect of exchange transfusion (ET) on the levels of immunoglobulins (Ig) and C3 in neonatal sepsis with sclerema.

Design: Randomized controlled trial in a referral neonatal unit of a teaching hospital.

Subjects: Consecutive culture positive septic neonates with sclerema were enrolled and were randomized to undergo ET (study group, n = 20) or no ET (controls, n = 20). Read More

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January 1997
3 Reads

Historical approach to scleroderma.

Clin Dermatol 1994 Apr-Jun;12(2):201-5

Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

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October 1994
3 Reads

A case of Hutchinson-Gilford progeria syndrome mimicking scleredema in early infancy.

Dermatology 1994 ;188(4):318-21

Department of Pediatrics, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

We report a case of Hutchinson-Gilford progeria syndrome (HGPS). The patient showed the characteristics of scleredema at the age of 2.5 months but developed all the manifestations of HGPS gradually until 10 months old. Read More

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June 1994
3 Reads

Pathological case of the month. Subcutaneous fat necrosis of the newborn.

Arch Pediatr Adolesc Med 1994 Jan;148(1):61-2

Department of Dermatology, Stanford University School of Medicine, Calif.

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January 1994
1 Read

Epidemiological study on hypothermia in newborns.

Chin Med J (Engl) 1993 Jun;106(6):428-32

Pediatric Department, PUMC Hospital, Beijing.

A study on the incidence and high risk factors of hypothermia in the newborn was carried out in a period of four months (Nov. 1988-Feb. 1989) in 6 counties of 3 provinces. Read More

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June 1993
4 Reads

Sclerema neonatorum--histopathologic study.

Indian J Pathol Microbiol 1993 Jan;36(1):45-7

Department of Pathology, R.G. Kar Medical College, Calcutta.

Histopathological study of 10 cases sclerema neonatorum showed subcutaneous fibrosis with lobulation in all the cases. 8 (80 percent) cases showed non-specific chronic inflammation of dermis and thinning of epidermis with atrophy of rete pegs and hypercollgenisation of dermis was evident in 70 percent cases. Fat necrosis with crystallisation of fat content was not a conspicuous feature. Read More

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January 1993
2 Reads

Unusual presentation of cytomegaloviral infection in a 5-month-old baby: case report.

P G Kini M Baliga

Ann Trop Paediatr 1993 ;13(4):395-7

Department of Paediatrics, Kasturba Medical College, Manipal, India.

Painful restricted movements of the extremities, hyperpigmentation over swollen joints, and a sclerema-like feel to the skin with increased serum triglyceride was seen in a 5-month-old baby with postnatal CMV infection. In an infant with pseudoparalysis of the limbs, the possibility of CMV infection has to be considered. Read More

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February 1994

[Panniculitis in children].

B Labeille

Ann Pediatr (Paris) 1992 Sep;39(7):419-25

Service de Dermatologie et Vénéréologie, Hôpital Sud, Amiens.

Panniculitis is an inflammation of subcutaneous fat responsible for fairly uniform clinical features including nodules, plaques or swelling located in the subcutaneous tissue, occasionally progressing to atrophy of subcutaneous fat. Some forms of panniculitis specific of childhood are responsible for readily recognizable clinical patterns. Examples include acute neonatal fat necrosis, sclerema neonatorum, cryopanniculitis, steroid-induced panniculitis, and toxoplasmosis-related multinodular fat necrosis of Royer syndrome. Read More

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September 1992

Neonatal peritonitis.

Turk J Pediatr 1992 Jul-Sep;34(3):157-66

Department of Pediatric Surgery, Cukurova University Faculty of Medicine, Adana, Turkey.

A retrospective study was undertaken over an eight-year period to assess the mortality rate of 66 newborns who had undergone surgery in our clinic because of peritonitis. The mortality rate for the patients admitted in poor condition was 95.2 percent, whereas it was 45. Read More

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February 1993

Restrictive dermopathy. Report of two affected siblings and a review of the literature.

Arch Dermatol 1992 Feb;128(2):228-31

Department of Dermatology, Stanford University, Calif.

Background: Restrictive dermopathy is a lethal genetic disorder consisting of abnormally tight skin, generalized joint contractures, distinctive facies, and pulmonary hypoplasia. Autosomal recessive inheritance has been suggested based on multiply affected siblings and some reports of parental consanguinity. This article describes two siblings with the restrictive dermopathy syndrome and reviews previously reported cases. Read More

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February 1992
3 Reads

Scleredema in a 6-week-old baby.

Indian Pediatr 1991 Oct;28(10):1195-7

Department of Pediatrics, Pathology and Surgery, King George's Medical College, Lucknow.

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October 1991

Dr Charles West (1816-98) of London and the cold syndrome.

P M Dunn

Arch Dis Child 1991 Apr;66(4 Spec No):455-6

University of Bristol, Southmead Hospital, Bristol.

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April 1991
6 Reads

Sclerema neonatorum and subcutaneous fat necrosis of the newborn in the same infant.

Eur J Pediatr 1990 Dec;150(2):125-6

Department of Paediatrics, Royal Free Hospital, London, UK.

Sclerema neonatorum (SN) is a rare disease of the newborn characterised by diffuse hardening of the subcutaneous adipose tissue. The condition is distinct from the localised violacious nodules observed in subcutaneous fat necrosis of the newborn (SCFN). Both conditions were diagnosed within the first 2 weeks of life in the same infant. Read More

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December 1990

[Subcutaneous adiponecrosis in newborn infants].

G Ital Dermatol Venereol 1990 Sep;125(9):389-92

Insegnamento di Dermatologia e Venereologia, Università degli Studi di Reggio Calabria, Sede di Catanzaro.

A case of subcutaneous fat necrosis of the newborn gave us the opportunity of re-examining this disease in the light of recent reports. Clinical, histological and laboratorial data do not show any specific pattern, although, seen as whole, they seem to form a picture distinguishable from sclerema neonatorum. Read More

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September 1990
5 Reads

[What is your diagnosis? Neonatal cytosteatonecrosis].

A Taïeb M Ball

Ann Dermatol Venereol 1989 ;116(1):47-9

Service de Dermatologie, Hôpital des Enfants, Bordeaux.

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June 1989
3 Reads

[Neonatal panniculitis].

A Taieb D Douard

Ann Pediatr (Paris) 1988 May;35(5):303-6

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May 1988
3 Reads

Sclerema neonatorum and subcutaneous fat necrosis of the newborn.

Pediatr Dermatol 1987 Aug;4(2):112-22

Department of Pathology, Micheal Reese Hospital and Medical Center, Chicago, IL 60616.

Sclerema neonatorum and subcutaneous fat necrosis are rare disorders affecting the panniculus of the newborn. This review attempts to put into perspective their similarities and differences in light of historical, biochemical, pathologic, and etiologic considerations. Recent therapeutic modalities and the prognosis are discussed. Read More

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August 1987
2 Reads

Sclerema neonatorum: a sign of transient hyperammonemia of the newborn.

J Pediatr Gastroenterol Nutr 1987 May-Jun;6(3):474-6

Department of Pediatrics, School of Medicine, University of California, Davis 95616.

We cared for four neonates with transient hyperammonemia of the newborn (THAN), all of whom exhibited sclerema during their course. Sclerema is a hardening of the subcutaneous tissues, which gives the tissue a firm, rubber-like quality. This association has not been previously reported, and it may provide a clue to early diagnosis and intervention in THAN. Read More

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Scleredema in an infant.

B Heilbron N Saxe

Arch Dermatol 1986 Dec;122(12):1417-9

A 3-month-old infant with scleredema had associated cytomegalovirus pneumonia with a rapidly fatal course. Because differentiation of scleredema from scleredema neonatorum, subcutaneous fat necrosis, and scleroderma may be difficult, histologic diagnosis is important. Cetylpyridinium chloride was used successfully as a fixative to demonstrate acid mucopolysaccharides histologically. Read More

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December 1986
3 Reads