205 results match your criteria Sclerema Neonatorum


Risk Factors for Mortality in Neonatal Gastric Perforation: A Retrospective Cohort Study.

Front Pediatr 2021 13;9:652139. Epub 2021 May 13.

Department of Neonatal Surgery, Children's Hospital of Chongqing Medical University, Chongqing, China.

Neonatal gastric perforation is a rare but life-threatening issue. The aim of this study was to describe the clinical characteristics and prognosis of patients with neonatal gastric perforation and identify predictive factors for poor prognosis. This was a retrospective cohort study of patients with neonatal gastric perforation treated in a tertiary pediatric public hospital between April 2009 and October 2020. Read More

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Sclerema Neonatorum in a Term Infant: A Case Report and Literature Review.

Case Rep Pediatr 2020 30;2020:8837064. Epub 2020 Dec 30.

Department of Surgery, Faculty of Clinical Medicine and Dentistry, Kampala International University, Kampala, Uganda.

Sclerema neonatorum (SN) is a rare form of panniculitides with an obscure incidence, aetiology, and pathogenesis. This condition is peculiar to preterm neonates, especially those with comorbidities such as sepsis, congenital anomalies, congenital heart disease, and gastrointestinal and respiratory diseases. Usually, it presents within the first seven days of life, but may develop a few weeks later. Read More

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December 2020

Subcutaneous fat necrosis of the newborn: clinical and histopathological review and use of cutaneous ultrasound Necrosis grasa subcutánea del recién nacido: revisión clínica e histopatológica y utilidad de la ecografía cutánea.

Dermatol Online J 2020 Nov 15;26(11). Epub 2020 Nov 15.

Servicio de Dermatología, Hospital Clínico Universitario, Valencia.

Subcutaneous fat necrosis of the newborn is a rare lobular panniculitis. It is characteristic of term or post-term neonates with a history of perinatal compromise or maternal gestational pathology. The cutaneous manifestations consist of erythematous and indurated subcutaneous plaques and nodules located over the dorsal region and the shoulders. Read More

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November 2020

Neonatal Skin Emergencies.

Pediatr Ann 2019 Jan;48(1):e36-e42

Although the majority of neonatal skin rashes can be safely monitored without intervention, there are a significant few that are dermatologic emergencies. When called to assess a neonate, it is important to distinguish what requires immediate diagnosis and treatment from those that represent benign etiologies. The skin may be the first clue to certain infections such as herpes simplex virus, syphilis, varicella, cytomegalovirus, fungal infections, and staphylococcal scalded skin syndrome, all of which require immediate testing and some of which may lead to severe sequelae. Read More

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January 2019

Newborn With Enlarged Erythematous Mass on Back: Case Report and Review of Medical Literature.

Glob Pediatr Health 2018 1;5:2333794X18803552. Epub 2018 Oct 1.

Wayne State University, Detroit, MI, USA.

Newborn skin nodules are usually benign and self-resolving skin condition. Differential diagnosis of such lesions include cysts, hemangioma, abscess, cellulitis, sclerema neonatorum, subcutaneous fat necrosis, neurofibromatosis, benign tumors, or malignant tumors such as rhabdomyosarcoma, infantile fibrosarcoma, or neuroblastoma. We report a case of congenital subcutaneous fat necrosis in a 7-day-old baby presenting with multiple erythematous mass on back. Read More

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October 2018

[Neonatal cytosteatonecrosis complicated by major hypercalcemia].

Pan Afr Med J 2018 30;29:86. Epub 2018 Jan 30.

Laboratoire de Biochimie, CHU Ibn Rochd, Université Hassan II, Casablanca, Maroc.

We here report the case of a female infant with perinatal asphyxia requiring resuscitation. She was referred with sclerema neonatorum which had been observed by parents on her tenth day of life. The lesions appeared as hard erythematous nodular plaques, suggesting neonatal cytosteatonecrosis in the gluteal region. Read More

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Sclerema Neonatorum in a Full-Term Infant Showing Favorable Prognosis.

Ann Dermatol 2017 Dec 30;29(6):790-793. Epub 2017 Oct 30.

Department of Dermatology, Gangnam Severance Hospital, Seoul, Korea.

Sclerema neonatorum (SN) is a rare disease characterized by firm, indurated, waxy skin lesions extending throughout the body, sparing the fat-free soles, palms, and genitalia. The prognosis of SN is generally very poor, with a high fatality rate. We report the case of a full-term infant with delayed onset of SN showing good prognosis. Read More

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December 2017

[Vascular anomalies in the neonatal period].

Cir Pediatr 2017 Jul 20;30(3):162-168. Epub 2017 Jul 20.

Servicio de Cirugía Pediátrica. Hospital Sant Joan de Déu. Barcelona.

Objective: Vascular anomalies in the neonatal period are a diagnostic challenge for the lack of evident signs, symptoms and follow-up, and the convenience of restricting aggressive diagnostic tests. The aim of this work is to review the characteristics of neonatal cases presented to our Vascular Anomalies Unit in the last 5 years.

Materials And Methods: All cases of suspected vascular anomaly presented to our unit before 1 month of age between 2010 and 2015 were reviewed, diagnostic tests and treatments carried out with chronology were analyzed. Read More

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Sclerema Neonatorum Treated Successfully with Parenteral Steroids: An Experience from a Resource Poor Country.

Case Rep Pediatr 2017 11;2017:4836142. Epub 2017 May 11.

Department of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, Nepal.

Sclerema neonatorum is a form of panniculitides characterized by diffuse hardening of subcutaneous tissue with minimal inflammation. It usually affects ill and preterm neonates. Prognosis is usually poor in many cases despite aggressive management. Read More

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Panniculitis: A summary.

Authors:
Mark R Wick

Semin Diagn Pathol 2017 May 27;34(3):261-272. Epub 2016 Dec 27.

Section of Dermatopathology,Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:

The diagnosis of panniculitis is felt to be a confusing topic by some pathologists. This summarical article presents inflammatory diseases of the subcutis in a systematic fashion, based on whether they are centered on fibrovascular septa or the adipose lobules, and whether morphologic vasculitis is present or not. Septocentric, non-vasculitis disorders include erythema nodosum, panniculitis that follows the use of "biological" therapeutic agents, lipodermatosclerosis, post-irradiation panniculitis, morphea profunda, and necrobiosis lipodica profunda. Read More

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[Effects of Ligustrazine Injection on Serum Cys C Level in Scierema Neonatorum Children Patients].

Zhongguo Zhong Xi Yi Jie He Za Zhi 2016 08;36(8):908-911

Objective To observe the effects of Ligustrazine Injection (LI) on serum cystatin C (Cys C) level in sclerema neonatorum (SN) children patients. Methods Totally 69 SN children patients were recrui- ted as the SN group, 39 with mild SN and 30 with moderate-severe SN. Another 30 neonates were recruited as a control group. Read More

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Delayed-Onset Sclerema Neonatorum in a Critically Ill Premature Infant.

Pediatr Dermatol 2016 Mar-Apr;33(2):e168-9

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Sclerema neonatorum is extremely rare in the 21st century. We report a premature infant managed in a neonatal intensive care unit with delayed development of sclerema neonatorum. Read More

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January 2017

Panniculitis with crystals induced by etanercept subcutaneous injection.

J Cutan Pathol 2015 Jun 1;42(6):413-5. Epub 2015 Apr 1.

Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain.

Panniculitis with lipid crystallization within adipocytes may be seen in several disorders, including crystal-storing histiocytosis, gouty panniculitis, subcutaneous fat necrosis of the newborn, post-steroid panniculitis, sclerema neonatorum, oxalosis and subcutaneous fungal infections by mucormycosis, zygomycosis or aspergillosis. Panniculitis at the sites of subcutaneous injection of drugs are frequent, but to our knowledge no crystals have been described in the drug-induced panniculitis at the sites of subcutaneous injections. We report on a patient who developed a panniculitis with lipid crystallization at the site of etanercept injection. Read More

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Sclerodermatous skin changes in an infant.

Pediatr Dermatol 2014 May-Jun;31(3):387-8

College of Medicine, Medical University of South Carolina, Charleston, South Carolina.

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December 2014

Recurrent sclerema in a young infant presenting with severe sepsis and severe pneumonia: an uncommon but extremely life-threatening condition.

J Health Popul Nutr 2013 Dec;31(4):538-42

Clinical Services Centre, icddr,b, GPO Box 128, Dhaka 1000, Bangladesh.

A one month and twenty-five days old baby girl with problems of acute watery diarrhoea, severe dehydration, severe malnutrition, and reduced activity was admitted to the gastrointestinal unit of Dhaka Hospital of icddr,b. The differentials included dehydration, dyselectrolytaemia and severe sepsis. She was treated following the protocolized management guidelines of the hospital. Read More

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December 2013

Sclerema neonatorum treated with intravenous immunoglobulin: a case report and review of treatments.

Cutis 2013 Aug;92(2):83-7

Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Ave S, EFH Set 414, Birmingham, AL 35294-0009, USA.

Sclerema neonatorum (SN) is a rare neonatal panniculitis that typically develops in severely ill, preterm newborns within the first week of life and often is fatal. It usually occurs in preterm newborns with delivery complications such as respiratory distress or maternal complications such as eclampsia. Few clinical trials have been performed to address potential treatments. Read More

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Panniculitis in children.

G Ital Dermatol Venereol 2013 Aug;148(4):371-85

Dipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche, Sezione di Dermatologia Università di Pavia, Fondazione IRCCS Policlinico "San Matteo", Pavia, Italia -

This paper will give a comprehensive view of the most frequent panniculitides seen in childhood, with emphasis on the types exclusively found in infancy, and for all other types of panniculitides also found in adults. Aim of this paper is also to analyze the clinical differences between panniculitis in childhood and in adulthood, and to give reliable histopathologic criteria for a specific diagnosis. A review of the literature is here integrated by authors' personal contribution. Read More

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Gemcitabine-associated livedoid thrombotic microangiopathy with associated sclerema neonatorum-like microscopic changes.

J Cutan Pathol 2012 Jul 22;39(7):707-11. Epub 2012 May 22.

Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain.

Gemcitabine is a deoxycytidine analog antimetabolite that is now accepted as first-line treatment for advanced and metastatic pancreatic carcinoma. Gemcitabine-related thrombotic microangiopathy associated with systemic hemolytic-uremic syndrome or thrombotic thrombocytopenia purpura has rarely been described. Herein, we report a patient who developed a livedoid thrombotic microangiopathy with no signs of associated hemolytic-uremic syndrome. Read More

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Panniculitis in childhood.

Dermatol Ther 2010 Jul-Aug;23(4):356-67

Section of Dermatology, University of Chicago Medical Center, Chicago, Illinois, USA.

Panniculitis refers to disorders with inflammation of the subcutaneous fat. Such inflammation can be primary or can be a reaction pattern induced by a systemic process. Some types of panniculitis are seen more commonly or exclusively in children. Read More

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November 2010

A firm plaque on the back of a newborn.

Dermatol Online J 2010 Feb 15;16(2):11. Epub 2010 Feb 15.

Department of Dermatology, University of Texas Health Science Center, San Antonio, Texas, USA.

We report a case of subcutaneous fat necrosis of the newborn (SCFN), a rare disorder in term or post-term neonates. Although it is often associated with hematological abnormalities such as anemia and hypercalcemia, SCFN in this patient presented with hyperbilirubinemia. The course of SCFN is generally benign and self-limiting, though may be associated with complications secondary to hypercalcemia. Read More

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February 2010

Risk factors for sclerema neonatorum in preterm neonates in Bangladesh.

Pediatr Infect Dis J 2009 May;28(5):435-8

Department of International Health, International Center for Advancing Neonatal Health, Johns Hopkins University, Baltimore, MD, USA.

Background: This study presents a retrospective analysis of risk factors for sclerema neonatorum in preterm neonates in Bangladesh.

Methods: Preterm neonates admitted to Dhaka Shishu Hospital in Bangladesh were enrolled in a clinical trial to evaluate the effects of topical treatment with skin barrier-enhancing emollients on prevention of sepsis and mortality. Four hundred ninety-seven neonates were enrolled in the study and 51 (10. Read More

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Predictors of mortality in infants with sclerema presenting to the Centre for Diarrhoeal Disease, Dhaka.

Ann Trop Paediatr 2009 Mar;29(1):45-50

International Centre for Diarrhoeal Disease Research, Bangladesh, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.

Background: Sclerema is an uncommon, life-threatening condition, usually of newborns, with a case-fatality rate ranging from 50 to 100%. Very little is known about factors influencing outcome.

Aim: To identify clinical and biochemical predictors associated with fatal outcome of sclerema in infants with diarrhoea. Read More

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Factors associated with sclerema in infants with diarrhoeal disease: a matched case-control study.

Acta Paediatr 2009 May 9;98(5):873-8. Epub 2009 Jan 9.

International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Aim: To identify clinical and biochemical factors associated with sclerema in infants with diarrhoeal illness, and their outcome.

Methods: In this case-control study, we enrolled 30 infants with clinical sepsis with sclerema (cases) and another 60, age- and sex-matched infants with clinical sepsis but without sclerema (controls) from among those admitted to the special care unit (SCU) and longer stay unit (LSU) of the Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) for their diarrhoeal illness from May 2005 through April 2006. Sclerema as the dependant variable while hypoxia, hypothermia, C-reactive protein (CRP) level, serum total protein and prealbumin level were the major independent variables compared in the analysis. Read More

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Panniculitis in children.

Dermatol Clin 2008 Oct;26(4):491-500, vii

Department of Dermatology, Hospital del Niño Jesús, C/Menéndez Pelayo 65, 28009 Madrid, Spain.

The panniculitides include a group of disorders of varied etiology that manifest as inflamed nodules in the subcutaneous tissue. They are rarely seen in infants and children. The panniculitides of the newborn represent a unique response of the infant's fat to different injuries, and are a specific type of panniculitis that is only seen in neonates and very young infants. Read More

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October 2008

Cold panniculitis.

Dermatol Clin 2008 Oct;26(4):485-9, vii

Department of Dermatology, Hospital Universitario La Paz, Universidad Autónoma, Paseo La Castellana, No. 261, 28046 Madrid, Spain.

Cold panniculitis has been described in children and young women following cold exposure. Histopathologically, cold panniculitis shows a mostly lobular panniculitis, which consists of an infiltrate of lymphocytes and histiocytes in the fat lobules. Usually, the dermis shows a superficial and deep perivascular infiltrate mostly composed of lymphocytes, with no vasculitis. Read More

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October 2008

Sclerema neonatorum: a review of nomenclature, clinical presentation, histological features, differential diagnoses and management.

Authors:
A Zeb G L Darmstadt

J Perinatol 2008 Jul 27;28(7):453-60. Epub 2008 Mar 27.

Department of International Health, International Center for Advancing Neonatal Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Objective: To review published literature on sclerema neonatorum (SN) in order to clarify its clinical presentation, histological features and management compared with two other diseases: subcutaneous fat necrosis of the newborn (SCFN) and scleredema.

Study Design: PubMed database was searched using the key words Sclerema neonatorum. A total of 55 articles from peer-reviewed journals were reviewed and summarized. Read More

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Sclerema neonatorum after therapeutic whole-body hypothermia.

Arch Dis Child Fetal Neonatal Ed 2007 Jul;92(4):F307

University Children's Hospital, Basel, Switzerland.

Hypothermia is being studied as a neuroprotective therapy after asphyxia. This report is about a term newborn with severe asphyxia who underwent systemic hypothermia (34.5 degrees C) for 72 h. Read More

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Normal subcutaneous fat, necrosis of adipocytes and classification of the panniculitides.

Authors:
Luis Requena

Semin Cutan Med Surg 2007 Jun;26(2):66-70

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

The panniculitides represent a group of heterogeneous inflammatory diseases that involve the subcutaneous fat. The specific diagnosis of these diseases requires histopathologic study because different panniculitides usually show the same clinical appearance, which consists of erythematous nodules on the lower extremities. However, the histopathologic study of panniculitis is difficult because of an inadequate clinicopathologic correlation and the changing evolutive nature of the lesions. Read More

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[Adiponecrosis subcutanea neonatorum in congenital pneumonia].

Hautarzt 2004 Jan;55(1):67-70

Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany.

In the course of a connatal pneumonia, a 7-day-old female newborn developed symmetrical subcutaneous nodules on her back, shoulders, and upper arms. These skin lesions were accompanied by hypercalcemia. Histological examination confirmed the putative clinical diagnosis of subcutaneous fat necrosis of the newborn. Read More

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January 2004