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Eur J Dermatol 2022 02;32(1):124-145

Dermatology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain, Instituto de Investigación Biosanitaria IBS. Granada, Spain.

J Scleroderma Relat Disord 2021 Oct 12;6(3):311-315. Epub 2021 May 12.

Department of General Internal Medicine, Akashi Medical Center, Akashi, Japan.

Scleredema is a rare cutaneous mucinosis characterized by diffuse swelling and non-pitting induration. A 63-year-old man reported a 5-year history of skin thickening of the trunk and a 3-week history of dyspnea. Echocardiography revealed diffuse hypokinesis. Read More

J Eur Acad Dermatol Venereol 2022 Jul 17;36(7):1016-1024. Epub 2022 Feb 17.

Dermatology Clinic, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Cutaneous mucinoses are a heterogenous group of conditions, characterized by the deposition of glycosaminoglycans (mucin) in the dermis, follicles, or in the epidermis. Major cutaneous mucinoses include lichen myxedematosus, scleredema, mucinoses associated with thyroid disease, reticular erythematous mucinosis, papulonodular mucinosis associated with connective tissue diseases, and cutaneous focal mucinosis. The aim of this review is to provide an update of what has currently been reported in the last 30-year literature about several new or emerging conditions of acquired cutaneous mucinoses in adults. Read More

Ann Dermatol 2021 Dec 4;33(6):586-588. Epub 2021 Nov 4.

Department of Dermatology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

Medicina (Kaunas) 2021 Nov 20;57(11). Epub 2021 Nov 20.

U.O. Dermatologia, Ospedale San Marco, 95123 Catania, Italy.

Scleroderma-like disorders include a set of entities involving cutis, subcutis and, sometimes, even muscular tissue, caused by several pathogenetic mechanisms responsible for different clinical-pathological pictures. The absence of antinuclear antibodies (ANA), Raynaud's phenomenon and capillaroscopic anomalies constitutes an important element of differential diagnosis with systemic sclerosis. When scleroderma can be excluded, on the basis of the main body sites, clinical evolution, any associated pathological conditions and specific histological features, it is possible to make a correct diagnosis. Read More

J Healthc Eng 2021 16;2021:7227928. Epub 2021 Oct 16.

Pediatric Department, Tianjin Medical University General Hospital, Tianjin 300052, China.

This article proposes that machine learning can break through the technical limitations of the linear growth test for the early physique of infants smaller than gestational age and can accurately calculate and predict the consequences of the disease. For testing the linear growth of the early physique of infants smaller than gestational age, the data collection and judgment are carried out according to the computer analysis method. Experimental results show that 47. Read More

Int J Dermatol 2021 Aug 19. Epub 2021 Aug 19.

Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.

J Postgrad Med 2021 Jul-Sep;67(3):174-176

Department of Pathology, SRM MCH&RC, Kattankulathur, Tamil Nadu, India.

Scleredema adultorum of Buschke is a rare disorder of the connective tissue, involving the skin. Here, we present a 61-year-old male, who is a known case of compensated liver cirrhosis with a past history of being treated for autoimmune thyrotoxicosis, who presented with complaints of alopecia, skin tightening, dry skin, pruritus, and woody indurated plaques on the skin of the upper back, shoulder, and arms. Skin biopsy of the arm revealed the characteristic features of scleredema. Read More

Semergen 2021 10 19;47(7):501-503. Epub 2021 Jun 19.

Servicio de Dermatología, Hospital Universitario Miguel Servet, Zaragoza, España.

Med Clin North Am 2021 Jul;105(4):681-697

Department of Dermatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Diabetes mellitus is a significant worldwide health concern and cutaneous manifestations are common. This review describes characteristic skin findings of diabetes, general skin findings related to diabetes, and findings related to diabetes treatment with a focus on clinical presentation, diagnosis, pathophysiology, epidemiology, and treatment. As the prevalence of diabetes continues to rise, cutaneous manifestations of diabetes mellitus likely will be encountered more frequently by physicians in all disciplines including dermatologists and primary care physicians. Read More

J Family Med Prim Care 2021 Feb 27;10(2):1037-1039. Epub 2021 Feb 27.

Second Department of Dermatology and Venereology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Scleredema diabeticorum is an uncommon skin disorder which is characterized by stiffness and hardening of the subcutaneous tissues located on the upper back and posterior neck. Patients with this skin disease typically experience pain and stiffness on the neck. Scleredema associated with diabetes mellitus may often go unrecognized. Read More

Lipids Health Dis 2021 May 5;20(1):47. Epub 2021 May 5.

Department of Rheumatology and Immunology, Medical School, University of Pécs, Akác u. 1, Pécs, H-7632, Hungary.

Background: Scleroedema adultorum of Buschke is a rare disorder characterized by fibromucinous thickening of the dermis that manifests mainly at the nape of the neck and on the upper back and shoulders. This study screened patients with diabetes mellitus for skin hardening caused by scleroedema adultorum of Buschke and characterized the clinical and laboratory findings in patients with newly identified cases, with a focus on lipid metabolism abnormalities and vascular complications.

Methods: Out of 113 consecutive patients with diabetes, 11 (9. Read More

Cutis 2021 Feb;107(2):74-78

Mr. Svoboda is from the Virginia Tech Carilion School of Medicine, Roanoke. Dr. Shields is from the Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison.

Hyperglycemia is defined by excess blood glucose and, when persistent, may lead to prediabetic and diabetic states. Insulin is a hormone produced by the beta cells of the pancreas in response to elevated blood glucose. Dysregulated insulin secretion or clearance results in hyperinsulinemia, which also is closely associated with type 2 diabetes mellitus (T2DM) and metabolic disturbances. Read More

Dermatol Online J 2021 Mar 15;27(3). Epub 2021 Mar 15.

Department of Dermatology, Hospital General Universitario de Ciudad Real, Ciudad Real.

Scleredema adultorum of Buschke is a rare skin disease characterized by skin thickening and tightening typically at the neck and the upper part of the body. This thickening results from increased mucin deposition in the reticular dermis. Three variants are recognized. Read More

J Diabetes Metab Disord 2020 Dec 16;19(2):989-996. Epub 2020 Sep 16.

General Practice, 66650 Banuyls-sur-Mer, France.

Introduction: Although type 2 diabetes mellitus (DM) is a global public health problem, the diabetes-associated dermatological (non-infectious) manifestations (DADM) remain poorly understood and under-diagnosed. We aimed to evaluate the prevalence of 7 known DADM in a primary care setting, and their association macro/microvascular complications.

Methods: Cross-sectionnal study included patients consulting in general practice for DM-follow up, from November 2016 to January 2017. Read More

J Am Acad Dermatol 2022 01 23;86(1):189-191. Epub 2021 Jan 23.

Dermatology Department, Hospital Clínic, University of Barcelona, Barcelona, Spain.

Cureus 2020 Dec 20;12(12):e12188. Epub 2020 Dec 20.

Dermatology, San Diego Family Dermatology, National City, USA.

Scleredema is a connective tissue disorder that presents as diffuse induration of skin, most often involving the upper body. Scleredema can be associated with prior infection, monoclonal gammopathy, and diabetes mellitus. Pyoderma gangrenosum is a neutrophilic dermatosis that presents as an ulcer with violaceous borders. Read More

J Clin Aesthet Dermatol 2020 Dec 1;13(12):E53-E55. Epub 2020 Dec 1.

All authors are with the Department of Dermatology, Faculty of Medicine at Jordan University of Science and Technology in Irbid, Jordan.

Scleredema is an idiopathic condition with specific clincopathological findings, including symmetrical and diffuse nonpitting induration of the upper body and thickened dermis due to deposition of acid mucopolysaccharides. Here, we report a case of linear scleredema in a healthy female patient, who presented with firm induration of the skin over her right shoulder and arm in a Blaschkolinear distribution. The onset was insidious in childhood and stable over several years. Read More

J Drugs Dermatol 2020 10;19(10):993-998

Hyaluronidase is mostly widely recognized for its off-label use in correction of complications of hyaluronic acid fillers. However, its utility in other aspects of dermatology is less widely acknowledged. We describe the varied uses of hyaluronidase in dermatology and the underlying evidence base for its dermatological indications. Read More

JAAD Case Rep 2020 Oct 28;6(10):1039-1041. Epub 2020 Jul 28.

Montgomery Cancer Center, Montgomery, Alabama.

Cutis 2020 07;106(1):14, 21-22

Bay Dermatology, Tampa, and Largo Medical Center, Florida, USA.

J R Coll Physicians Edinb 2020 Mar;50(1):32-34

Department of Medicine, VMMC and Safdarjung Hospital, Delhi, India.

Scleroedema is a rare clinical condition characterised by diffuse woody induration of skin commonly associated with diabetes mellitus, infections and monoclonal gammopathy. Its association with ovarian malignancy has not been reported. We report a case of a 56-year-old female with rapidly progressing skin thickening of limbs, face and trunk for 1 year and abdominal distension for 3 months. Read More

Int J Dermatol 2020 Nov 12;59(11):e427-e429. Epub 2020 Jun 12.

Dermatology Unit, Hospital Universitario San Cecilio, Granada, Spain.

Clin Dermatol 2020 Mar - Apr;38(2):235-249. Epub 2019 Oct 24.

Department of Rheumatology and Immunology, University of Pécs Clinical Center, Pecs, Hungary. Electronic address:

Sclerodermalike syndromes (SLSs) comprise diseases with mucin deposition (eg, scleromyxedema, scleredema), with eosinophilia (eg, eosinophilic fasciitis), metabolic or biochemical abnormalities (eg, nephrogenic systemic fibrosis), or endocrine disorders (eg, POEMS syndrome, or polyneuropathy, organomegaly, endocrinopathy, monoclonal lymphoproliferative disorder, and hypothyroidism). Chronic graft-versus-host disease may also show sclerodermalike skin changes. Inherited progeria syndromes with early aging (eg, Werner syndrome) and a heterogeneous group of hereditary disorders with either skin thickening (eg, stiff skin syndrome) or atrophy and tightening (eg, acrogeria) can also imitate classic systemic sclerosis (SSc). Read More

J Dermatol 2020 Jul 6;47(7):e267-e269. Epub 2020 May 6.

Department of Dermatology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.

J Eur Acad Dermatol Venereol 2020 Mar 12;34(3):e133-e135. Epub 2019 Dec 12.

Department of Dermatology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

JAAD Case Rep 2019 Nov 24;5(11):940-942. Epub 2019 Oct 24.

Department of Dermatology, University of Rochester Medical Center, Rochester, New York.

Australas J Dermatol 2020 Feb 10;61(1):e110-e111. Epub 2019 Sep 10.

Department of Dermatology, Waikato Hospital, Hamilton, New Zealand.

Panminerva Med 2021 06 26;63(2):240-241. Epub 2019 Jul 26.

Department of Pediatrics -