494 results match your criteria Scleredema


[A case report of foot wounds repair in patient with systemic sclerosis].

Zhongguo Gu Shang 2019 Jan;32(1):85-87

Department of Hand Surgery, Ningbo No.6 Hospital, Ningbo 315000, Zhejiang, China;

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.01.019DOI Listing
January 2019

Intravenous immunoglobulin treatment: Where do dermatologists stand?

Authors:
Selma Emre

Dermatol Ther 2019 Feb 13:e12854. Epub 2019 Feb 13.

Department of Dermatology, Yildirim Beyazit University, Medical School, Ankara, Turkey.

Intravenous immunoglobulins (IVIG) are therapeutic products, comprising polyclonal IgGs, which are obtained from human plasma pool of healthy blood donors. Despite the lack of Food and Drug Administration (FDA) approval, the experience of using IVIG in various dermatological diseases increases day by day and exciting results are reported. However, experience with the use of IVIG in dermatological indications are mostly case reports whereas randomized, controlled, double-blind, multicentric studies have not been performed. Read More

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http://dx.doi.org/10.1111/dth.12854DOI Listing
February 2019
5 Reads

Scleredema diabeticorum: Description of 11 cases.

Med Clin (Barc) 2019 Feb 1. Epub 2019 Feb 1.

Unidad de Diabetes, Endocrinología y Nutrición, Hospital General de Granollers, Granollers, Barcelona, España.

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http://dx.doi.org/10.1016/j.medcli.2018.12.008DOI Listing
February 2019

Anti-carbamylated protein antibodies and skin involvement in patients with systemic sclerosis: An intriguing association.

PLoS One 2018 31;13(12):e0210023. Epub 2018 Dec 31.

Department of Biomedical Sciences and Human Oncology (DIMO), Rheumatologic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy.

Carbamylation is a post-translational modification that mostly affects proteins with low turnover, such as dermal proteins. Carbamylated proteins accumulate in skin in an age-dependent manner, contributing to tissue alterations. As dermis is affected by systemic sclerosis (SSc) and anti-carbamylated protein antibodies (anti-CarP Ab) are found in SSc patients, we sought to evaluate the specificity of anti-CarP Ab and their relationship with clinical parameters reflecting skin involvement in SSc. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312283PMC
December 2018
1 Read

[Efficacy and safety of selective brain hypothermia therapy on neonatal hypoxic-ischemic encephalopathy].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1046-1050

Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China (Chen X, Peng WS, Zhang Z, Zhao Q, Zhou Y, Chen L); Department of Pediatric, Anhui Provincial Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui, China (Pan JH). Corresponding author: Pan Jiahua, Email:

Objective: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100.

Methods: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.011.007DOI Listing
November 2018
2 Reads

Scleredema of Buschke associated with lichen sclerosus: Three cases.

Indian J Dermatol Venereol Leprol 2018 Oct 4. Epub 2018 Oct 4.

"Mario Aresu" Department of Medical Science, Section of Dermatology, University of Cagliari, Cagliari, Italy.

Scleredema adultorum of Buschke is a rare fibromucinous, scleroderma-like connective tissue disease most commonly found in a post-infectious setting or linked to hematological disorders or diabetes. Lichen sclerosus et atrophicus is an autoimmune condition only in 2.5% of cases localized exclusively at an extragenital site, occurring in up to 34% of patients in association with other autoimmune diseases such as vitiligo, thyroid disorders, alopecia areata, lichen planus, morphea, pernicious anemia and systemic lupus erythematosus. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_288_17DOI Listing
October 2018
7 Reads

Coexisting cutaneous macroglobulinosis and scleredema of Buschke in a patient with a Waldenström Macroglobulinemia.

J Eur Acad Dermatol Venereol 2019 Mar 28;33(3):e104-e106. Epub 2019 Feb 28.

Department of Immuno-Hematology, Saint-Louis Hospital, Assistance Publique - Hôpitaux de Paris, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75010, Paris, France.

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http://dx.doi.org/10.1111/jdv.15268DOI Listing
March 2019
8 Reads

[Diffuse pain in a 63-year-old man].

Rev Med Interne 2018 Nov 22;39(11):891-893. Epub 2018 Sep 22.

Service de médecine interne, hôpital Saint-Éloi, 80, boulevard Augustin-Fliche, 34295 Montpellier, France.

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https://linkinghub.elsevier.com/retrieve/pii/S02488663183057
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http://dx.doi.org/10.1016/j.revmed.2018.05.004DOI Listing
November 2018
1 Read

[Scleredema adultorum : Clinical presentation, diagnostic workup, differential diagnosis, treatment option].

Authors:
A Kreuter

Hautarzt 2018 Nov;69(11):908-915

Klinik für Dermatologie, Venerologie und Allergologie, HELIOS St. Elisabeth Klinik Oberhausen, Universität Witten/Herdecke, Josefstr. 3, 46045, Oberhausen, Deutschland.

Scleredema adultorum (SA) is a rare scleromucinous disease of unknown etiology that characteristically leads to wodden induration located on the neck and upper trunk. Three types of SA can be distinguished according to the association with pre-existing or underlying disease: SA in association with infections (mostly streptococcal infections of the upper respiratory tract), SA in association with monoclonal gammopathy, and SA in association with diabetes. The clinical findings, extent of disease, and course substantially differ depending on the subtype of SA. Read More

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http://dx.doi.org/10.1007/s00105-018-4259-6DOI Listing
November 2018
2 Reads

An Unusual Presentation of a Rare Scleroderma Mimic: What is Behind the Scenes?

Curr Rheumatol Rev 2019 ;15(2):172-175

Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, El-Abaseya, Egypt.

Background: Scleroderma or systemic sclerosis (SSc) is a rare systemic autoimmune disease. Many conditions mimic the presentation of SSc, especially skin thickening and fibrosis. One of these conditions is scleredema, a rare collagen and mucin deposition disorder which was found to be associated with diabetes mellitus, streptococcal infection or monoclonal gammopathy. Read More

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http://www.eurekaselect.com/164442/article
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http://dx.doi.org/10.2174/1573397114666180808091621DOI Listing
January 2019
11 Reads

Scleredema Diabeticorum with Superimposed Cellulitis and Abscess Formation.

Case Rep Endocrinol 2018 16;2018:9513768. Epub 2018 Apr 16.

Interfaith Medical Center, Brooklyn, NY, USA.

Scleredema diabeticorum is a rare cutaneous manifestation of diabetes mellitus. We present a case of an obese male with poorly controlled diabetes who came to the hospital with upper back pain and subsequently developed sepsis due to a small deep-seated abscess in his back that was drained and treated with antibiotics. He was also found to have extensive induration of the skin over his back and neck. Read More

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http://dx.doi.org/10.1155/2018/9513768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926487PMC
April 2018
2 Reads

Ultrasonographic Findings of Scleredema Adultorum of Buschke Involving the Posterior Neck.

Korean J Radiol 2018 May-Jun;19(3):425-430. Epub 2018 Apr 6.

Department of Pathology, Dong-A University College of Medicine, Busan 49201, Korea.

Objective: To describe the clinical and ultrasonographic (US) findings in patients with scleredema adultorum of Buschke, who presented with sclerotic skin on their posterior neck.

Materials And Methods: After obtaining IRB approval, eight patients with scleredema adultorum of Buschke were enrolled. They underwent US examination of their posterior neck. Read More

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http://dx.doi.org/10.3348/kjr.2018.19.3.425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904469PMC
February 2019
3 Reads

[Buschke's scleredema successfully treated with extracorporeal photopheresis].

Rev Med Interne 2018 May 12;39(5):360-363. Epub 2018 Mar 12.

Service de médecine interne, hôpital Victor-Provo, 11, boulevard Lacordaire, 59170 Roubaix, France.

Background: Scleredema adultorum (Buschke's scleredema) is a cutaneous mucinosis of unknown origin, clinically characterized by a diffuse induration of the skin usually involving the neck, shoulders and back, which limits patients' mobility.

Case Report: We report a case of a 50-year-old woman who presented a chronic sclerodermiform syndrome for 2 years associated with type 1 diabetes. Physical examination revealed an extensive skin induration involving the shoulders, neck and back. Read More

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http://dx.doi.org/10.1016/j.revmed.2018.02.018DOI Listing
May 2018
3 Reads

Successful Treatment of Scleredema Diabeticorum With Tranilast: Three Case Reports.

Diabetes Care 2018 Apr 26;41(4):e40-e41. Epub 2018 Jan 26.

Department of Dermatology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

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http://dx.doi.org/10.2337/dc17-1994DOI Listing
April 2018
5 Reads

Scleroderma with an update about clinico-pathological correlation.

G Ital Dermatol Venereol 2018 Apr 24;153(2):208-215. Epub 2018 Jan 24.

Department of Molecular Medicine, "Sapienza" University, Rome, Italy.

Scleroderma is divided into a systemic form called systemic sclerosis and a localized form also called morphea. According to 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis, developed by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR), skin thickening of the fingers extending proximal to the metacarpophalangeal joints is sufficient for a patient to be classified as having scleroderma. Histological examination is not included in the diagnostic criteria and is not routinely performed. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.05922-9DOI Listing
April 2018
8 Reads

[SKIN PATHOLOGY IN DIABETES MELLITUS: CLINICAL AND PATHOPHYSIOLOGICAL CORRELATIONS (REVIEW)].

Georgian Med News 2017 Dec(273):41-46

Shupyk National Medical Academy of Postgraduate Education; Ukrainian Research and Practical Centre of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine.

Skin pathology is registered in vast majority of patients with diabetes mellitus (DM). Despite the abundance of publications on dermatological problems in DM, there is still a number of gaps to be discussed in terms of pathophysiological mechanisms. The goal of this review was to assess the mechanisms of development of different skin pathologies under DM. Read More

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December 2017
1 Read

Miscellaneous skin disease and the metabolic syndrome.

Clin Dermatol 2018 Jan - Feb;36(1):94-100. Epub 2017 Sep 8.

Department of Dermatology, Istanbul Medeniyet University, Medical School, Istanbul, Turkey. Electronic address:

The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X173017
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http://dx.doi.org/10.1016/j.clindermatol.2017.09.016DOI Listing
August 2018
49 Reads

Treatment of Scleroedema Adultorum Buschke: A Systematic Review.

Acta Derm Venereol 2018 Mar;98(3):305-309

Department of Dermatology, Jena University Hospital Erfurter Straße 35, DE-07743 Jena, Germany.

Scleroedema adultorum Buschke is a rare skin disease, which can be divided into 3 subtypes: classic type, occurring after respiratory infections; a type lacking association with infections; and a type associated with diabetes. Scleroedema adultorum Buschke is characterized by thickening and tightening of the skin, which typically starts at the neck. In half of patients, spontaneous remission may occur. Read More

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http://dx.doi.org/10.2340/00015555-2846DOI Listing
March 2018
5 Reads

Paclitaxel-related scleredema-like skin changes in a patient with breast cancer.

Australas J Dermatol 2018 Aug 25;59(3):e215-e217. Epub 2017 Sep 25.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan.

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http://dx.doi.org/10.1111/ajd.12719DOI Listing
August 2018
18 Reads

Serositis in a child with scleredema of Buschke: an unusual association and improvement following glucocorticoids.

Scand J Rheumatol 2018 07 12;47(4):342-343. Epub 2017 Sep 12.

a Department of Pediatrics, Allergy and Immunology Unit, Advanced Pediatrics Centre , Postgraduate Institute of Medical Education and Research , Chandigarh , India.

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https://www.tandfonline.com/doi/full/10.1080/03009742.2017.1
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http://dx.doi.org/10.1080/03009742.2017.1340513DOI Listing
July 2018
6 Reads

Pathophysiological Mechanisms in Sclerosing Skin Diseases.

Front Med (Lausanne) 2017 18;4:120. Epub 2017 Aug 18.

Department of Dermatology, University of Cologne, Cologne, Germany.

Sclerosing skin diseases represent a large number of distinct disease entities, which include systemic sclerosis, localized scleroderma, and scleredema adultorum. These pathologies have a common clinical appearance and share histological features. However, the specific interplay between cytokines and growth factors, which activate different mesenchymal cell populations and production of different extracellular matrix components, determines the biomechanical properties of the skin and the clinical features of each disease. Read More

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http://dx.doi.org/10.3389/fmed.2017.00120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563304PMC
August 2017
7 Reads

European dermatology forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis.

J Eur Acad Dermatol Venereol 2017 Oct 8;31(10):1581-1594. Epub 2017 Aug 8.

Department of Dermatology and Venereology, University Hospital of Cologne, Cologne, Germany.

The term 'sclerosing diseases of the skin' comprises specific dermatological entities which have fibrotic changes of the skin in common. These diseases mostly manifest in different clinical subtypes according to cutaneous and extracutaneous involvement and can sometimes be difficult to distinguish from each other. The present guideline focuses on characteristic clinical and histopathological features, diagnostic scores and the serum autoantibodies most useful for differential diagnosis. Read More

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http://dx.doi.org/10.1111/jdv.14466DOI Listing
October 2017
11 Reads

Implementation and evaluation of a rehabilitation concept in a patient suffering from Scleredema Adultorum Buschke: a case report.

Disabil Rehabil 2018 11 24;40(23):2833-2835. Epub 2017 Jul 24.

a Department of Physical Medicine, Rehabilitation and Occupational Medicine , Medical University of Vienna , Vienna , Austria.

Purpose: Scleredema Adultorum Buschke is a disorder manifesting indurations of the skin mostly followed by musculoskeletal impairment. Data regarding this fact are seldom found and documentation of functional outcome of physical therapies and modalities related to Scleredema Adultorum Buschke is fragmentary. The aim of this case report is to demonstrate and to document an effective concept of rehabilitation in a patient suffering from Scleredema Adultorum Buschke. Read More

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https://www.tandfonline.com/doi/full/10.1080/09638288.2017.1
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http://dx.doi.org/10.1080/09638288.2017.1355939DOI Listing
November 2018
7 Reads

Cutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review.

Clin Rev Allergy Immunol 2017 Dec;53(3):306-336

Section of Dermatology, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse cutaneous systemic sclerosis with divergent patterns of organ involvement, autoantibody profiles, management, and prognostic implications. Although systemic sclerosis is considered the disease prototype that causes cutaneous sclerosis, there are many other conditions that can mimic and be confused with SSc. They can be classified into immune-mediated/inflammatory, immune-mediated/inflammatory with abnormal deposit (mucinoses), genetic, drug-induced and toxic, metabolic, panniculitis/vascular, and (para)neoplastic disorders according to clinico-pathological and pathogenetic correlations. Read More

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http://dx.doi.org/10.1007/s12016-017-8625-4DOI Listing
December 2017
34 Reads

Scleroderma-like Disorders.

Authors:
Amit Sharma

Curr Rheumatol Rev 2018 Apr;14(1):22-27

Fortis Escorts Hospital, Jaipur, Rajasthan, India.

Background: Scleroderma is a term used to describe diseases that involve hardening and tightening of the skin and the underlying subcutaneous connective tissue. It could be localized to skin and subcutaneous tissue, or may involve the internal organs too in systemic sclerosis.

Objective: There are disorders that can cause hardening and tightening of skin and mimic scleroderma but are rarely associated with Raynaud phenomenon, sclerodactyly, and autoantibodies in the serum, features specific to scleroderma/systemic sclerosis. Read More

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http://dx.doi.org/10.2174/1573397113666170612091419DOI Listing
April 2018
25 Reads

Successful treatment with IVIg therapy of diabetes-associated scleredema severe progressive case and review of the literature.

Dermatol Ther 2017 Jul 2;30(4). Epub 2017 Jun 2.

Department of Medicine, University of Central Florida, Orlando, Florida.

Scleredema is a deposition disorder which presents as diffuse, symmetric, non-pitting skin induration from dermal deposits of glycosaminoglycans ("mucins"). It classically affects the upper back and posterior neck, often causing skin tightness and decreased range of motion. In most patients the clinical course is chronic and treatment options are limited. Read More

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http://dx.doi.org/10.1111/dth.12504DOI Listing
July 2017
27 Reads

Scleroderma Mimickers.

Curr Treatm Opt Rheumatol 2016 Mar 5;2(1):69-84. Epub 2016 Feb 5.

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Cutaneous fibrosing disorders encompass a diverse array of diseases united by the presence of varying degrees of dermal sclerosis. The quality and distribution of skin involvement, presence or absence of systemic complications and unique associated laboratory abnormalities often help to distinguish between these diseases. It is imperative that an effort is made to accurately differentiate between scleroderma and its mimics, in order to guide long-term management and facilitate implementation of the appropriate treatment modality where indicated. Read More

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http://dx.doi.org/10.1007/s40674-016-0038-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412724PMC
March 2016
23 Reads

Scleredema of Buschke with prominent periorbital edema.

Int J Dermatol 2017 10 2;56(10):e193-e194. Epub 2017 May 2.

Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, Rome, Italy.

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http://dx.doi.org/10.1111/ijd.13639DOI Listing
October 2017
22 Reads

Cutaneous Manifestations of Diabetes Mellitus: A Review.

Am J Clin Dermatol 2017 Aug;18(4):541-553

Department of Dermatology, University Hospital Jena, Erfurter Straße 35, 07740, Jena, Germany.

Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Read More

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http://dx.doi.org/10.1007/s40257-017-0275-zDOI Listing
August 2017
15 Reads

Scleredema of Buschke.

Eur J Rheumatol 2016 Dec 1;3(4):191-192. Epub 2016 Feb 1.

Department of Internal Medicine, Division of Rheumatology, Oakwood Hospital, Dearborn, Michigan, USA.

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http://dx.doi.org/10.5152/eurjrheum.2015.0052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283571PMC
December 2016
4 Reads

Therapy resistant idiopathic scleredema: an underlying pathology not always present.

Eur J Rheumatol 2015 Dec 20;2(4):163-164. Epub 2015 May 20.

Department of Internal Medicine, Division of Rheumatology, Ege University Faculty of Medicine, İzmir, Turkey.

Scleredema is a rare connective tissue disorder of unknown pathogenesis. Three types of scleredema have been described, based on its association with postinfection, monoclonal gammopathy and diabetes mellitus. We report herein a case of scleredema which the diagnosis didn't get specified. Read More

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http://dx.doi.org/10.5152/eurjrheum.2015.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047231PMC
December 2015
16 Reads

Atypical Scleredema Involving the Hands in an Adolescent.

Pediatr Dermatol 2016 Nov 30;33(6):e342-e343. Epub 2016 Aug 30.

Division of Dermatology, Medical College of Georgia at Augusta University, Augusta, GA.

Scleredema is a rare and incompletely understood disorder characterized by progressive skin thickening and induration typically affecting the trunk, neck, and proximal upper extremities. Hand and finger involvement is exceptionally rare, having been reported in only two infection-related cases. We present an atypical case of postinfectious scleredema involving the hands and discuss scleredema as an important potential cause of hand tightness and induration in adolescents. Read More

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http://dx.doi.org/10.1111/pde.12951DOI Listing
November 2016
3 Reads

[Risk factors for concurrent sepsis in neonates with necrotizing enterocolitis].

Zhongguo Dang Dai Er Ke Za Zhi 2016 Aug;18(8):677-82

Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University/National Demonstration Base of Standardized Training Base for Resident Physicians/Ministry of Education Key Laboratory of Child Development and Disorders/Key Laboratory of Pediatrics in Chongqing/Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing 400014, China.

Objective: To investigate the risk factors for concurrent sepsis in neonates with necrotizing enterocolitis (NEC).

Methods: A retrospective analysis was performed for the clinical data of 273 neonates with NEC. The risk factors for concurrent sepsis were analyzed from the aspects of perinatal factors and treatment regimen before the diagnosis of NEC. Read More

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August 2016
6 Reads

Laboratory Testing in the Setting of Diabetic Scleredema--Reply.

JAMA 2016 Aug;316(5):543

Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1001/jama.2016.6647DOI Listing
August 2016
1 Read

Laboratory Testing in the Setting of Diabetic Scleredema.

Authors:
David Alter

JAMA 2016 Aug;316(5):542

Spectrum Health Regional Laboratory, Grand Rapids, Michigan.

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http://dx.doi.org/10.1001/jama.2016.6644DOI Listing
August 2016
2 Reads

Scleredema of Buschke associated with difficult-to-control type 2 diabetes mellitus.

Rev Assoc Med Bras (1992) 2016 May-Jun;62(3):199-201

MSc in Anatomical Pathology from UFF. Adjunct Professor, Pathology, UFF, Niterói, RJ, Brazil.

Scleredema of Buschke (SB) is a rare disorder of connective tissue characterized by diffuse non-pitting induration of the skin, mainly on the cervical, deltoid and dorsal regions. It is a cutaneous mucinosis of unknown etiology and is associated with bacterial or viral infections, hematological disorders and diabetes mellitus. Histopathological examination shows thickened dermis with wide collagen bundles separated by gaps that correspond to mucopolysaccharide deposits, visualized using special staining. Read More

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http://dx.doi.org/10.1590/1806-9282.62.03.199DOI Listing
April 2015
5 Reads

Benign lesion on the posterior aspect of the neck.

Cutis 2016 May;97(5):348;351;352

Departments of Dermatology and Pathology, Cleveland Clinic, Ohio, USA.

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May 2016
2 Reads

Neck Pain, Stiffness, and Periorbital Edema in a Man With Diabetes.

JAMA 2016 Mar;315(11):1159-60

Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, Ohio.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2016.1770DOI Listing
March 2016
5 Reads

[Scleroderma-like disorders].

Rev Med Interne 2016 Sep 3;37(9):616-24. Epub 2016 Feb 3.

Service de médecine interne, hôpital Robert-Bisson, 4, rue Roger-Aini, 14100 Lisieux, France.

The finding of hardening and thickening of the skin is common and can be encountered in immune mediated, metabolic, neoplastic, toxic, genetic diseases, or associated with protein deposits. The lack of Raynaud's phenomenon, capillaroscopic abnormalities, or scleroderma-specific autoantibodies should question the diagnosis of scleroderma and trigger the search for a scleroderma-like disorder, for which treatment and prognosis differ. This article gives a review of these disorders and their main characteristics. Read More

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http://dx.doi.org/10.1016/j.revmed.2015.12.033DOI Listing
September 2016
9 Reads

[Monoclonal immunoglobulin (M-Ig) and skin diseases from the group of mucinoses--scleredema adultorum Buschke and scleromyxedema. Description of four cases and an overview of therapies].

Vnitr Lek 2015 Dec;61(12):1072-87

Introduction: The mucinoses of the type of scleredema and scleromyxedema are diseases marked by excessive production of mucin deposits in the skin and subcutaneous tissue, which causes skin hardening. The skin and subcutaneous deposits hamper the movement of limbs, the thorax as well as mouth. The same mechanism also damages other organs (the heart, lungs, oesophagus). Read More

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December 2015
28 Reads

Idiopathic scleredema.

Dermatol Online J 2016 Dec 15;22(12). Epub 2016 Dec 15.

Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.

Scleredema, which also is known as scleredemaadultorum of Buschke, is an uncommonsclerodermiform condition that is characterizedby progressive thickening and hardening of theskin due to excessive dermal mucin and collagendeposition. The clinical course is variable, andprogression of disease may lead to functionalimpairment with limitations in mobility. The etiologyand pathogenesis are unknown although severalwell-known associations include streptococcalinfection; diabetes mellitus, particularly withmetabolic syndrome; and monoclonal gammopathy. Read More

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December 2016
10 Reads

Long-term benefit of electron beam radiation therapy in the treatment of scleredema of Buschke.

Adv Radiat Oncol 2016 Jan-Mar;1(1):21-25. Epub 2015 Dec 9.

Department of Radiation Oncology, Division of Dermatology, University of Arizona, Tucson, Arizona.

Introduction: Scleredema of Buschke is a rare connective tissue disorder presenting with woody thickening and induration of the nuchal and shoulder regions resulting in progressive decrease in the range of motion of the neck. Treatment options include several forms of systemic therapy with variable results. Local radiation therapy (RT) is often thought of as a secondary form of therapy. Read More

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http://dx.doi.org/10.1016/j.adro.2015.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506738PMC
December 2015
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Prevalence of Skin Changes in Diabetes Mellitus and its Correlation with Internal Diseases: A Single Center Observational Study.

Indian J Dermatol 2015 Sep-Oct;60(5):465-9

Department of Medicine, Sanjiban Hospital, Kolkata, India.

Background And Aim: This single-center observational cross-sectional study has been done in an attempt to find out the prevalence of various skin manifestations in diabetes patients (DM) and their correlation with diabetes control and complications.

Materials And Methods: Skin manifestations present over 12 months among those attend diabetes clinic were included in the study. Apart from demographic data and type, patients were also screened for micro vascular complications and control of diabetes over last 3 months. Read More

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http://dx.doi.org/10.4103/0019-5154.164363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601413PMC
November 2015
4 Reads

Scleredema adultorum of Buschke with prominent periorbital edema in a Tunisian patient with diabetes mellitus: a case report.

Int J Dermatol 2016 Feb 4;55(2):e100-2. Epub 2015 Nov 4.

Department of Dermatology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.

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http://dx.doi.org/10.1111/ijd.13128DOI Listing
February 2016
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Scleredema Diabeticorum - A Case Report.

Mymensingh Med J 2015 Jul;24(3):606-9

Dr Md Nahiduzzamane Shazzad, Medical Officer, Department of Rheumatology, Bangabandhu Sheikh Mujib MedicalUniversity (BSMMU), Dhaka, Bangladesh.

Buschke Scleredema is a rare connective tissue disorder of unknown aetiology and characterized by thickening of the dermis. It resembles systemic sclerosis, eosinophilic fasciitis and cutaneous amyloidosis. Scleredema may be associated with a history of an antecedent febrile illness, diabetes mellitus, or blood dyscrasia. Read More

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July 2015
7 Reads

Scleredema associated with Sjögren's syndrome.

An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):81-3

Garcia de Orta Hospital, Almada, PT.

Scleredema adultorum of Buschke is a rare disorder characterized by diffuse swelling and non-pitting induration of the skin usually involving the face, neck, arms and upper trunk. It has been associated with previous infectious diseases, diabetes, paraproteinemia and, more rarely, malignant neoplasms or autoimmune disorders. We report the case of a 30-year-old man who presented with a 2-year history of scleredema. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20153779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540515PMC
January 2016
6 Reads

Scleredema. A multicentre study of characteristics, comorbidities, course and therapy in 44 patients.

J Eur Acad Dermatol Venereol 2015 Dec 24;29(12):2399-404. Epub 2015 Aug 24.

Service de Dermatopathologie, Paris, France.

Background: The prognostic and therapeutic features of scleredema are poorly documented.

Objectives: To describe the characteristics of patients with scleredema regarding demographics, clinical characteristics, comorbidities, therapeutic interventions and course.

Methods: We conducted a retrospective multicentre study. Read More

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http://doi.wiley.com/10.1111/jdv.13272
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http://dx.doi.org/10.1111/jdv.13272DOI Listing
December 2015
9 Reads

Scleredema of Buschke Following Streptococcal Infection.

Ann Dermatol 2015 Aug 29;27(4):478-80. Epub 2015 Jul 29.

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.5021/ad.2015.27.4.478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530171PMC
August 2015
4 Reads

Detection of renal brush border membrane enzymes for evaluation of renal injury in neonatal scleredema.

Pak J Med Sci 2015 Jan-Feb;31(1):65-9

Qiaozhi Yang, MD, Department of Pediatrics, Liaocheng People's Hospital, Liaocheng, Shandong252000, China.

Objective: To evaluate renal brush border membrane enzymes in urine as an indicator for renal injury in neonatal scleredema (NS).

Methods: Sixty nine NS patients in our hospital were enrolled and divided into mild group and moderate/severe group. Patients were further randomly divided into therapy and control subgroups for 7 days ligustrazine administration. Read More

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http://dx.doi.org/10.12669/pjms.311.5740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386159PMC
April 2015
6 Reads