89,094 results match your criteria Scientific reports[Journal]


High-throughput combinatorial screening of multi-component electrolyte additives to improve the performance of Li metal secondary batteries.

Sci Rep 2019 Apr 17;9(1):6211. Epub 2019 Apr 17.

Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, 560-8531, Japan.

Data-driven material discovery has recently become popular in the field of next-generation secondary batteries. However, it is important to obtain large, high quality data sets to apply data-driven methods such as evolutionary algorithms or Bayesian optimization. Combinatorial high-throughput techniques are an effective approach to obtaining large data sets together with reliable quality. Read More

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http://dx.doi.org/10.1038/s41598-019-42766-xDOI Listing

Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta.

Sci Rep 2019 Apr 17;9(1):6225. Epub 2019 Apr 17.

Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.

High levels of atherogenic lipids in pregnancy are associated with health complications for the mother, the fetus and the newborn. As endocrine secretory tissue, the human placenta releases apolipoproteins (apos), particularly apoA1 and apoE. However, the magnitude and the directionality of the apo secretions remain unknown. Read More

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http://www.nature.com/articles/s41598-019-42522-1
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http://dx.doi.org/10.1038/s41598-019-42522-1DOI Listing
April 2019
1 Read

Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses.

Sci Rep 2019 Apr 17;9(1):6224. Epub 2019 Apr 17.

Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary.

Glucose is a major fuel for the central nervous system and hypoglycemia is a significant homeostatic stressor, which elicits counterregulatory reactions. Hypothalamic metabolic- and stress-related neurons initiate these actions, however recruitment of glia in control such adaptive circuit remain unknown. Groups of fed- and fasted-, vehicle-injected, and fasted + insulin-injected male mice were compared in this study. Read More

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http://dx.doi.org/10.1038/s41598-019-42728-3DOI Listing

Uncovering the hidden marine sponge microbiome by applying a multi-primer approach.

Sci Rep 2019 Apr 17;9(1):6214. Epub 2019 Apr 17.

Centre for Marine Bioproducts Development, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, 5042, Australia.

Marine sponges (phylum Porifera) are hosts to microorganisms that make up to 40-60% of the mesohyl volume. The challenge is to characterise this microbial diversity more comprehensively. To accomplish this, a new method was for the first time proposed to obtain sequence coverage of all the variable regions of the 16S rRNA gene to analyze the amplicon-based microbiomes of four representative sponge species belonging to different orders. Read More

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http://dx.doi.org/10.1038/s41598-019-42694-wDOI Listing

Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide.

Sci Rep 2019 Apr 17;9(1):6203. Epub 2019 Apr 17.

Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States.

Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease burden areas. However, diagnosing bacteremia is challenging for clinicians, especially in children presenting with co-infections such as malaria and HIV. Read More

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http://dx.doi.org/10.1038/s41598-019-42502-5DOI Listing

Intracellular Fe accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage.

Sci Rep 2019 Apr 17;9(1):6228. Epub 2019 Apr 17.

Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, 501-1196, Japan.

After intracranial hemorrhage (ICH), iron is released from the hematoma and induces secondary brain injury. However, the detail effect of iron on blood-brain barrier (BBB) function is still unknown. We investigated whether hemoglobin (Hb), ferrous ammonium sulfate (FAS) or hemin which contains iron have the detrimental effect on both human brain microvascular endothelial cells and pericytes by cellular function analysis in vitro. Read More

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http://dx.doi.org/10.1038/s41598-019-42370-zDOI Listing

Magnetic moment inversion at giant flux jump: dynamical property of critical state in type-II superconductors.

Sci Rep 2019 Apr 17;9(1):6233. Epub 2019 Apr 17.

Institute of Physics, Polish Academy of Sciences, Aleja Lotników 32/46, PL-02668, Warsaw, Poland.

Experimental evidence of tremendous magnetic moment dynamical inversion, from metastable trapping state to the state with essentially the same moment oriented in the opposite direction, appearing during giant flux jump connected to thermomagnetic avalanche process in superconducting YBaCuO single crystal, is presented. Magnetization inversion takes place in the system, without thermal contact between sample and sample holder, with a tremendous stored energy once the avalanche process is completed in quasi-adiabatic conditions. A model of magnetic moment inversion, caused by the jump between two metastable states of superconductor with the same energy storage, is presented and discussed in terms of the critical state with peculiar evolution of the critical-current spatial distribution. Read More

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http://www.nature.com/articles/s41598-019-42699-5
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http://dx.doi.org/10.1038/s41598-019-42699-5DOI Listing
April 2019
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Novel, rare and common pathogenic variants in the CFTR gene screened by high-throughput sequencing technology and predicted by in silico tools.

Sci Rep 2019 Apr 17;9(1):6234. Epub 2019 Apr 17.

Department of Medical Genetics and Genomic Medicine, School of Medical Sciences, University of Campinas. Tessália Vieira de Camargo, 126, Barão Geraldo, Cidade Universitária Zeferino Vaz, CEP: 13083-887, Campinas, São Paulo, Brazil.

Cystic fibrosis (CF) is caused by ~300 pathogenic CFTR variants. The heterogeneity of which, challenges molecular diagnosis and precision medicine approaches in CF. Our objective was to identify CFTR variants through high-throughput sequencing (HTS) and to predict the pathogenicity of novel variants through in 8 silico tools. Read More

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http://dx.doi.org/10.1038/s41598-019-42404-6DOI Listing

Renal Denervation for Resistant Hypertension in the contemporary era: A Systematic Review and Meta-analysis.

Sci Rep 2019 Apr 17;9(1):6200. Epub 2019 Apr 17.

Division of Cardiovascular Diseases, Mayo Clinic Arizona, Phoenix, Arizona, USA.

Renal denervation (RDN) is a catheter-based ablation procedure designed to treat resistant hypertension (RH). The objective of our study is to determine the effect of RDN on blood pressure and renal function in patients with RH in comparison to medical therapy alone. We performed an extensive literature search for randomized control trials (RCT) reporting office and 24 hr. Read More

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http://dx.doi.org/10.1038/s41598-019-42695-9DOI Listing

Exploiting the interplay between cross-sectional and longitudinal data in Class III malocclusion patients.

Sci Rep 2019 Apr 17;9(1):6189. Epub 2019 Apr 17.

Department of Experimental and Clinical Medicine, Orthodontics, Università degli Studi di Firenze, Florence, Italy.

The aim of the study was to investigate how to improve the forecasting of craniofacial unbalance risk during growth among patients affected by Class III malocclusion. To this purpose we used computational methodologies such as Transductive Learning (TL), Boosting (B), and Feature Engineering (FE) instead of the traditional statistical analysis based on Classification trees and logistic models. Such techniques have been applied to cephalometric data from 728 cross-sectional untreated Class III subjects (6-14 years of age) and from 91 untreated Class III subjects followed longitudinally during the growth process. Read More

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http://dx.doi.org/10.1038/s41598-019-42384-7DOI Listing

Assessment of body adiposity preterm children at the beginning of school age.

Sci Rep 2019 Apr 17;9(1):6207. Epub 2019 Apr 17.

Medical Faculty, Institute of Physiotherapy, University of Rzeszow, Rejtana 16c, Rzeszów, 35-959, Poland.

In Poland, like in other developed countries, 6.3% of babies are born prematurely. Preterm babies suffer from numerous health issues. Read More

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http://www.nature.com/articles/s41598-019-42715-8
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http://dx.doi.org/10.1038/s41598-019-42715-8DOI Listing
April 2019
1 Read

Author Correction: Resistance training regulates gene expression of molecules associated with intramyocellular lipids, glucose signaling and fiber size in old rats.

Sci Rep 2019 Apr 17;9(1):6383. Epub 2019 Apr 17.

Graduate program of Rehabilitation Sciences, University of Brasilia, Distrito Federal, Brazil.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42462-wDOI Listing

Prevention of hatching of porcine morulae and blastocysts by liquid storage at 20 °C.

Sci Rep 2019 Apr 17;9(1):6219. Epub 2019 Apr 17.

Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, 30100, Murcia, Spain.

Vitrification is the ideal method for long-lasting storage of porcine embryos. However, both strict airline regulations for transport of liquid nitrogen dewars and the technical problems experienced when vitrified embryos are transferred using non-surgical procedures have led to the introduction of alternative storage methods, such as preserving embryos in liquid state. This study evaluated whether a pH-stable medium containing high concentrations of either foetal calf serum (FCS; 50%) or BSA (4%) combined with storage at temperatures of 17 °C or 20 °C maintained in vivo-derived morulae and blastocysts alive and unhatched (a sanitary requirement for embryo transportation) during 72 h of storage. Read More

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http://www.nature.com/articles/s41598-019-42712-x
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http://dx.doi.org/10.1038/s41598-019-42712-xDOI Listing
April 2019
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Loss of PKM2 in Lgr5 intestinal stem cells promotes colitis-associated colorectal cancer.

Sci Rep 2019 Apr 17;9(1):6212. Epub 2019 Apr 17.

Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine/Asan Medical Center, Seoul, Republic of Korea.

The regulatory properties of pyruvate kinase M2 isoform (PKM2), the key glycolytic enzyme, influence altered energy metabolism including glycolysis in cancer. In this study, we found that PKM2 was highly expressed in patients with ulcerative colitis or colorectal cancer (CRC). We then investigated the effectiveness of conditionally ablating PKM2 in Lgr5 intestinal stem cells (ISC) using a mouse model of colitis-associated CRC (AOM plus DSS). Read More

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http://dx.doi.org/10.1038/s41598-019-42707-8DOI Listing

Near full-length HIV-1 subtype B sequences from the early South African epidemic, detecting a BD unique recombinant form (URF) from a sample in 1985.

Sci Rep 2019 Apr 17;9(1):6227. Epub 2019 Apr 17.

Division of Medical Virology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town, 8000, South Africa.

HIV-1 subtype C is the most prevalent subtype in South Africa. Although subtype B was previously detected in South Africa, there is limited sequence information available. We characterized near full-length HIV-1 subtype B sequences from samples collected at the start of the South African HIV-1 epidemic, in the 1980s. Read More

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http://www.nature.com/articles/s41598-019-42417-1
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http://dx.doi.org/10.1038/s41598-019-42417-1DOI Listing
April 2019
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Author Correction: Photonic Spin Hall Effect in Waveguides Composed of Two Types of Single-Negative Metamaterials.

Sci Rep 2019 Apr 17;9(1):6405. Epub 2019 Apr 17.

Key Laboratory of Advanced Micro-structure Materials, MOE, School of Physics Science and Engineering, Tongji University, Shanghai, 200092, China.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42460-yDOI Listing

Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling.

Sci Rep 2019 Apr 17;9(1):6199. Epub 2019 Apr 17.

Group of Applied Mechanics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain.

The tumour microenvironment (TME) has recently drawn much attention due to its profound impact on tumour development, drug resistance and patient outcome. There is an increasing interest in new therapies that target the TME. Nonetheless, most established in vitro models fail to include essential cues of the TME. Read More

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http://www.nature.com/articles/s41598-019-42529-8
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http://dx.doi.org/10.1038/s41598-019-42529-8DOI Listing
April 2019
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De Novo Transcriptome Assembly and Functional Annotation in Five Species of Bats.

Sci Rep 2019 Apr 17;9(1):6222. Epub 2019 Apr 17.

Escuela Nacional de Ciencias Biológicas, Posgrado Químicobiológicas, Instituto Politécnico Nacional, Departamento de Zoología, Ciudad de México, CDMX, Mexico.

High-throughput RNA sequencing is a powerful tool that allows us to perform gene prediction and analyze tissue-specific overexpression of genes, but also at species level comparisons can be performed, although in a more restricted manner. In the present study complete liver transcriptomes of five tropical bat species were De novo assembled and annotated. Highly expressed genes in the five species were involved in glycolysis and lipid metabolism pathways. Read More

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http://dx.doi.org/10.1038/s41598-019-42560-9DOI Listing

Quantitative dynamics of reversible platelet aggregation: mathematical modelling and experiments.

Sci Rep 2019 Apr 17;9(1):6217. Epub 2019 Apr 17.

Faculty of Physics, Lomonosov Moscow State University, 1/2 Leninskie gory, Moscow, 119991, Russia.

Although reversible platelet aggregation observed in response to ADP stimulation in the presence of calcium is a well-known phenomenon, its mechanisms are not entirely clear. To study them, we developed a simple kinetic mass-action-law-based mathematical model to use it in combination with experiments. Light transmission platelet aggregometry (LTA) induced by ADP was performed for platelet-rich plasma or washed platelets using both conventional light transmission and aggregate size monitoring method based on optical density fluctuations. Read More

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http://www.nature.com/articles/s41598-019-42701-0
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http://dx.doi.org/10.1038/s41598-019-42701-0DOI Listing
April 2019
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Author Correction: TGF-β1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells.

Sci Rep 2019 Apr 17;9(1):6400. Epub 2019 Apr 17.

Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42588-xDOI Listing

Phenazine-1-carboxamide functionalized mesoporous silica nanoparticles as antimicrobial coatings on silicone urethral catheters.

Sci Rep 2019 Apr 17;9(1):6198. Epub 2019 Apr 17.

Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Hyderabad, 500007, India.

Microbial infections due to biofilms on medical implants can be prevented by antimicrobial coatings on biomaterial surfaces. Mesoporous silica nanoparticles (MSNPs) were synthesized via base-catalyzed sol-gel process at room temperature, functionalized with phenazine-1-carboxamide (PCN) and characterized by UV-visible, FT-IR, DLS, XRD spectroscopic techniques, SEM, TEM, TGA and BET analysis. Native MSNPs, PCN and PCN-MSNPs were evaluated for anti-Candida minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC), Candida albicans (C. Read More

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http://dx.doi.org/10.1038/s41598-019-42722-9DOI Listing

Hot electron-driven electrocatalytic hydrogen evolution reaction on metal-semiconductor nanodiode electrodes.

Sci Rep 2019 Apr 17;9(1):6208. Epub 2019 Apr 17.

Center for Nanomaterials and Chemical Reactions, Institute for Basic Science, Daejeon, 305-701, Republic of Korea.

Hot electrons generated on metal catalysts influence atomic and molecular processes, leading to hot electron-driven catalytic reactions. Here, we show the acceleration of electrocatalytic hydrogen evolution caused by internal injection of hot electrons on Pt/Si metal-semiconductor electrodes. When a forward bias voltage is applied to the Pt/Si contact, hot electrons are injected. Read More

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http://dx.doi.org/10.1038/s41598-019-42566-3DOI Listing

Galectin-3 and β-trace protein concentrations are higher in clinically unaffected patients with Fabry disease.

Sci Rep 2019 Apr 17;9(1):6235. Epub 2019 Apr 17.

Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), University of Murcia, CIBERCV, Murcia, Spain.

Current therapies have not shown benefit in organ damage reversal in Fabry disease (FD), but biomarkers could help risk stratification and prognosis. We investigated if several biomarkers of cardiac fibrosis, cardiac wall stress, myocardial injury, renal function and inflammation, are associated with early cardiac affectation in FD patients. We included FD patients from four cardiology outpatient clinics of southeastern Spain. Read More

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http://dx.doi.org/10.1038/s41598-019-42727-4DOI Listing

Surface modification on MoO/Mo(110) induced by a local electric potential.

Sci Rep 2019 Apr 17;9(1):6216. Epub 2019 Apr 17.

School of Physics and Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Dublin 2, Ireland.

Oxygen adatoms on the MoO/Mo(110) surface are observed to be removed when a sufficiently large bias is applied between the scanning tunneling microscope tip and the surface. Experimental observations, such as the bias polarity dependence of adatom removal and the observation of an intermediate state, indicate that the adatom penetrates the surface oxide layer. Through the comparison of finite element method simulations with various experimental relationships, the electric field is concluded to be the sole contributor to adatom penetration into the surface oxide layer. Read More

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http://www.nature.com/articles/s41598-019-42536-9
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http://dx.doi.org/10.1038/s41598-019-42536-9DOI Listing
April 2019
1 Read

Conformational plasticity in the KcsA potassium channel pore helix revealed by homo-FRET studies.

Sci Rep 2019 Apr 17;9(1):6215. Epub 2019 Apr 17.

CQFM-IN and iBB-Institute for Bioengineering and Bioscience, Instituto Superior Técnico, Universidade de Lisboa, 1049-001, Lisboa, Portugal.

Potassium channels selectivity filter (SF) conformation is modulated by several factors, including ion-protein and protein-protein interactions. Here, we investigate the SF dynamics of a single Trp mutant of the potassium channel KcsA (W67) using polarized time-resolved fluorescence measurements. For the first time, an analytical framework is reported to analyze the homo-Förster resonance energy transfer (homo-FRET) within a symmetric tetrameric protein with a square geometry. Read More

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http://www.nature.com/articles/s41598-019-42405-5
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http://dx.doi.org/10.1038/s41598-019-42405-5DOI Listing
April 2019
1 Read

Author Correction: One-plasmid double-expression His-tag system for rapid production and easy purification of MS2 phage-like particles.

Sci Rep 2019 Apr 17;9(1):6377. Epub 2019 Apr 17.

Veterinary Research Institute, Hudcova 296/70, 621 00, Brno, Czech Republic.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-39693-2DOI Listing

Disentangling host-parasite-pathogen interactions in a varroa-resistant honeybee population reveals virus tolerance as an independent, naturally adapted survival mechanism.

Sci Rep 2019 Apr 17;9(1):6221. Epub 2019 Apr 17.

Department of Ecology, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden.

The ectoparasitic mite, Varroa destructor, is unarguably the leading cause of honeybee (Apis mellifera) mortality worldwide through its role as a vector for lethal viruses, in particular, strains of the Deformed wing virus (DWV) and Acute bee paralysis virus (ABPV) complexes. This multi-level system of host-parasite-pathogen interactions makes it difficult to investigate effects of either the mite or the virus on natural host survival. The aim of this study was to remove confounding effects of varroa to examine the role of virus susceptibility in the enhanced survival of a naturally adapted Swedish mite-resistant (MR) honeybee population, relative to mite-susceptible (MS) honeybees. Read More

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http://dx.doi.org/10.1038/s41598-019-42741-6DOI Listing

DNA insecticide developed from the Lymantria dispar 5.8S ribosomal RNA gene provides a novel biotechnology for plant protection.

Sci Rep 2019 Apr 17;9(1):6197. Epub 2019 Apr 17.

Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Avenue 5/7, 295051, Simferopol, Crimea, Ukraine.

Having observed how botanicals and other natural compounds are used by nature to control pests in the environment, we began investigating natural polymers, DNA and RNA, as promising tools for insect pest management. Over the last decade, unmodified short antisense DNA oligonucleotides have shown a clear potential for use as insecticides. Our research has concentrated mainly on Lymantria dispar larvae using an antisense oligoRING sequence from its inhibitor-of-apoptosis gene. Read More

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http://dx.doi.org/10.1038/s41598-019-42688-8DOI Listing

The effect of exogenous melatonin on reducing scoliotic curvature and improving bone quality in melatonin-deficient C57BL/6J mice.

Sci Rep 2019 Apr 17;9(1):6202. Epub 2019 Apr 17.

Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing University, Nanjing, China.

It is well-documented that melatonin deficiency has been linked to the etiopathogenesis of adolescent idiopathic scoliosis. In this study, we intended to apply melatonin in melatonin-deficient mice to ascertain whether melatonin could reduce the incidence/severity of scoliosis, and investigate the role of melatonin on bone mineral density in scoliosis. A total of 80 mice were divided into 4 groups: 20 quadrupedal mice and 20 bipedal mice served as controls; 20 quadrupedal and 20 bipedal mice received oral melatonin (8 mg/kg BW) daily. Read More

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http://dx.doi.org/10.1038/s41598-019-42467-5DOI Listing

NDV-3A vaccination prevents C. albicans colonization of jugular vein catheters in mice.

Sci Rep 2019 Apr 17;9(1):6194. Epub 2019 Apr 17.

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

NDV-3A, a novel fungal vaccine undergoing clinical trials, contains a recombinant version of the Candida albicans rAls3 N-terminus protein (rAls3p-N) in aluminum hydroxide. In a Phase 1b/2a clinical trial, NDV-3A protected women from recurrent vulvovaginal candidiasis. Here, we reveal that active immunization in mice with NDV-3A induces high titers of anti-rAls3p-N antibodies that interfere with C. Read More

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http://dx.doi.org/10.1038/s41598-019-42517-yDOI Listing

Impact of slow breathing on the blood pressure and subarachnoid space width oscillations in humans.

Sci Rep 2019 Apr 17;9(1):6232. Epub 2019 Apr 17.

Department of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland.

The aim of the study was to assess cardiac and respiratory blood pressure (BP) and subarachnoid space (SAS) width oscillations during the resting state for slow and fast breathing and breathing against inspiratory resistance. Experiments were performed on a group of 20 healthy volunteers (8 males and 12 females; age 25.3 ± 7. Read More

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http://dx.doi.org/10.1038/s41598-019-42552-9DOI Listing

Comparison of multi-tissue aging between human and mouse.

Sci Rep 2019 Apr 17;9(1):6220. Epub 2019 Apr 17.

Geneis (Beijing) Co. Ltd, Beijing, 100102, P. R. China.

With the rapid growth of the aging population, exploring the biological basis of aging and related molecular mechanisms has become an important topic in modern scientific research. Aging can cause multiple organ function attenuations, leading to the occurrence and development of various age-related metabolic, nervous system, and cardiovascular diseases. In addition, aging is closely related to the occurrence and development of tumors. Read More

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http://www.nature.com/articles/s41598-019-42485-3
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http://dx.doi.org/10.1038/s41598-019-42485-3DOI Listing
April 2019
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Maternal body mass index moderates antenatal depression effects on infant birthweight.

Sci Rep 2019 Apr 17;9(1):6213. Epub 2019 Apr 17.

Department of Women's and Children's Health, Uppsala University, 751 85, Uppsala, Sweden.

Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a large for gestational age (LGA) infant. However, the effect of co-morbid depression has received little attention. Read More

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http://dx.doi.org/10.1038/s41598-019-42360-1DOI Listing

Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus.

Sci Rep 2019 Apr 17;9(1):6196. Epub 2019 Apr 17.

Pediatric Genomics Discovery Program, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.

Cerebrospinal fluid (CSF) flow in the brain ventricles is critical for brain development. Altered CSF flow dynamics have been implicated in congenital hydrocephalus (CH) characterized by the potentially lethal expansion of cerebral ventricles if not treated. CH is the most common neurosurgical indication in children effecting 1 per 1000 infants. Read More

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http://dx.doi.org/10.1038/s41598-019-42549-4DOI Listing

Low serum C3 level, high neutrophil-lymphocyte-ratio, and high platelet-lymphocyte-ratio all predicted poor long-term renal survivals in biopsy-confirmed idiopathic membranous nephropathy.

Sci Rep 2019 Apr 17;9(1):6209. Epub 2019 Apr 17.

Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Idiopathic membranous nephropathy (iMN) is the major cause of end-stage renal disease (ESRD). Recent guidelines suggest limiting immunosuppressants only to high risk patients for ESRD. The present study is aimed at identifying new predictors for the renal outcome of iMN patients. Read More

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http://dx.doi.org/10.1038/s41598-019-42689-7DOI Listing

Novel screening system revealed that intracellular cholesterol trafficking can be a good target for colon cancer prevention.

Sci Rep 2019 Apr 17;9(1):6192. Epub 2019 Apr 17.

Division of Prevention, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

In conventional research methods for cancer prevention, cell proliferation and apoptosis have been intensively targeted rather than the protection of normal or benign tumor cells from malignant transformation. In this study, we aimed to identify candidate colon cancer chemopreventive drugs based on the transcriptional activities of TCF/LEF, NF-κB and NRF2, that play important roles in the process of malignant transformation. We screened a "validated library" consisting of 1280 approved drugs to identify hit compounds that decreased TCF/LEF and NF-κB transcriptional activity and increased NRF2 transcriptional activity. Read More

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http://www.nature.com/articles/s41598-019-42363-y
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http://dx.doi.org/10.1038/s41598-019-42363-yDOI Listing
April 2019
1 Read

Microbial Community Dynamics During Lake Ice Freezing.

Sci Rep 2019 Apr 17;9(1):6231. Epub 2019 Apr 17.

Department of Biological Sciences, Michigan Technology University, Houghton, MI, USA.

Many freshwater environments experience dramatic seasonal changes with some systems remaining ice-covered for most of the winter. Freshwater systems are also highly sensitive to environmental change. However, little is known about changes in microbial abundance and community composition during lake ice formation and times of persistent ice cover. Read More

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http://www.nature.com/articles/s41598-019-42609-9
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http://dx.doi.org/10.1038/s41598-019-42609-9DOI Listing
April 2019
1 Read

Author Correction: Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size.

Sci Rep 2019 Apr 17;9(1):6395. Epub 2019 Apr 17.

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Departament de Medicina, Barcelona, Spain.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42591-2DOI Listing

Limb linkage rehabilitation training-related changes in cortical activation and effective connectivity after stroke: A functional near-infrared spectroscopy study.

Sci Rep 2019 Apr 17;9(1):6226. Epub 2019 Apr 17.

Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Center for Rehabilitation Technical Aids, Beijing, 100176, China.

Stroke remains the leading cause of long-term disability worldwide. Rehabilitation training is essential for motor function recovery following stroke. Specifically, limb linkage rehabilitation training can stimulate motor function in the upper and lower limbs simultaneously. Read More

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http://dx.doi.org/10.1038/s41598-019-42674-0DOI Listing

Author Correction: Effect of Low-Dose Alcohol Consumption on Inflammation Following Transient Focal Cerebral Ischemia in Rats.

Sci Rep 2019 Apr 17;9(1):6404. Epub 2019 Apr 17.

Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA.

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http://dx.doi.org/10.1038/s41598-019-42589-wDOI Listing

Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice.

Sci Rep 2019 Apr 17;9(1):6201. Epub 2019 Apr 17.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

The underlying pathogenesis of chronic kidney disease involves an activated renin-angiotensin system and systemic inflammation which ultimately develop renal injury. Rikkunshito (RKT) has been reported to exert anti-fibrotic and anti-inflammatory effects through enhancement of ghrelin signaling pathway. In this study, we investigated the effects of RKT on renal fibrosis and inflammation in angiotensin II (Ang II)-induced renal injury model. Read More

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http://www.nature.com/articles/s41598-019-42657-1
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http://dx.doi.org/10.1038/s41598-019-42657-1DOI Listing
April 2019
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Role of phospho-ezrin in differentiating thyroid carcinoma.

Sci Rep 2019 Apr 17;9(1):6190. Epub 2019 Apr 17.

Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.

Comprehensive theory explaining the relationship between estrogen (E2) and ezrin in metastasis of thyroid cancer remains non-elicited. In vitro results revealed that E2 could stimulate the expression and phosphorylation of ezrin in a time and dose dependent manner. Our data clearly showed that E2 enhanced the migration and invasion of cells, which was reversed by the transfection of cells with ezrin specific siRNA. Read More

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http://dx.doi.org/10.1038/s41598-019-42612-0DOI Listing

Enigmatic incongruence between mtDNA and nDNA revealed by multi-locus phylogenomic analyses in freshwater snails.

Sci Rep 2019 Apr 17;9(1):6223. Epub 2019 Apr 17.

Graduate school of Life Sciences, Tohoku University, Miyagi, Japan.

Phylogenetic incongruence has frequently been encountered among different molecular markers. Recent progress in molecular phylogenomics has provided detailed and important information for evolutionary biology and taxonomy. Here we focused on the freshwater viviparid snails (Cipangopaludina chinensis chinensis and C. Read More

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http://www.nature.com/articles/s41598-019-42682-0
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http://dx.doi.org/10.1038/s41598-019-42682-0DOI Listing
April 2019
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ITGA2 as a potential nanotherapeutic target for glioblastoma.

Sci Rep 2019 Apr 17;9(1):6195. Epub 2019 Apr 17.

Vascular Biology Program, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, United States.

High grade gliomas, including glioblastoma (GBM), are the most common and deadly brain cancers in adults. Here, we performed a quantitative and unbiased screening of 70 cancer-related antigens using comparative flow cytometry and, for the first time, identified integrin alpha-2 (ITGA2) as a novel molecular target for GBM. In comparison to epidermal growth factor receptor (EGFR), a well-established GBM target, ITGA2 is significantly more expressed on human GBM cells and significantly less expressed on normal human glial cells. Read More

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http://dx.doi.org/10.1038/s41598-019-42643-7DOI Listing

Organoid culture media formulated with growth factors of defined cellular activity.

Sci Rep 2019 Apr 17;9(1):6193. Epub 2019 Apr 17.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

The media formulations necessary for deriving and sustaining organoids from epithelial tissues such as prostate, colon, gastric, liver, pancreas, and others have been established. Critical components of organoid media are a set of growth factors that include R-spondins and BMP signalling antagonists such as Noggin or Gremlin 1. Currently, the practical limitations for formulating organoid media of reproducible potency and larger-scale media production that have hampered further technological applications of organoid technology include: the cost of growth factors such as R-spondins and Gremlin 1/Noggin and their production as defined specific activities free of contaminants that may affect organoid growth. Read More

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http://dx.doi.org/10.1038/s41598-019-42604-0DOI Listing

Estimation of swine movement network at farm level in the US from the Census of Agriculture data.

Sci Rep 2019 Apr 17;9(1):6237. Epub 2019 Apr 17.

Department of Electrical & Computer Engineering, Kansas State University, Manhattan, Kansas, United States of America.

Swine movement networks among farms/operations are an important source of information to understand and prevent the spread of diseases, nearly nonexistent in the United States. An understanding of the movement networks can help the policymakers in planning effective disease control measures. The objectives of this work are: (1) estimate swine movement probabilities at the county level from comprehensive anonymous inventory and sales data published by the United States Department of Agriculture - National Agriculture Statistics Service database, (2) develop a network based on those estimated probabilities, and (3) analyze that network using network science metrics. Read More

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http://www.nature.com/articles/s41598-019-42616-w
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http://dx.doi.org/10.1038/s41598-019-42616-wDOI Listing
April 2019
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Functional Analysis of Conserved Transmembrane Charged Residues and a Yeast Specific Extracellular Loop of the Plasma Membrane Na/H Antiporter of Schizosaccharomyces pombe.

Sci Rep 2019 Apr 17;9(1):6191. Epub 2019 Apr 17.

Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.

The Na/H exchanger of the plasma membrane of S. pombe (SpNHE1) removes excess intracellular sodium in exchange for an extracellular proton. We examined the functional role of acidic amino acids of a yeast specific periplasmic extracellular loop 6 (EL6) and of Glu and Arg of transmembrane segment 3. Read More

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http://dx.doi.org/10.1038/s41598-019-42658-0DOI Listing

Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis.

Sci Rep 2019 Apr 17;9(1):6206. Epub 2019 Apr 17.

Division of Allergy & Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking. To address this, we utilized full thickness human donor esophagi to create and validate the ex vivo function of mucosa and smooth muscle (n = 25). Explanted tissue was tested for contractile responses to carbachol and histamine. Read More

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http://dx.doi.org/10.1038/s41598-019-41147-8DOI Listing

Geographic separation and genetic differentiation of populations are not coupled with niche differentiation in threatened Kaiser's spotted newt (Neurergus kaiseri).

Sci Rep 2019 Apr 17;9(1):6239. Epub 2019 Apr 17.

Department of Evolutionary Biology, Unit Molecular Ecology, Zoological Institute, Technische Universität Braunschweig, 38106, Braunschweig, Germany.

The combination of niche modelling and landscape genetics (genomics) helps to disentangle processes that have shaped population structure in the evolutionary past and presence of species. Herein, we integrate a comprehensive genomic dataset with ecological parameters and niche modelling for the threatened Kaiser's newt, a newt species adapted to mountain spring-ponds in Iran. Genomic analysis suggests the existence of two highly differentiated clades North and South of the Dez River. Read More

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http://dx.doi.org/10.1038/s41598-019-41886-8DOI Listing

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.

Sci Rep 2019 Apr 17;9(1):6210. Epub 2019 Apr 17.

Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109-5632, USA.

Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy characterized by severe, pharmacoresistant seizures and the highest risk of Sudden Unexpected Death in Epilepsy (SUDEP) of all epilepsy syndromes. Here, we investigated the time course of maturation of neuronal GABAergic signaling in the Scn1b and Scn1a mouse models of DS. We found that GABAergic signaling remains immature in both DS models, with a depolarized reversal potential for GABA-evoked currents compared to wildtype in the third postnatal week. Read More

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http://dx.doi.org/10.1038/s41598-019-42191-0DOI Listing