3,434,868 results match your criteria Science


Nanodrug-Loaded Bifidobacterium bifidum Conjugated with Anti-Death Receptor Antibody for Tumor-Targeted Photodynamic and Sonodynamic Synergistic Therapy.

Acta Biomater 2022 May 14. Epub 2022 May 14.

Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, P. R. China.. Electronic address:

Using bacteria for tumor-targeted therapy has attracted much attention in recent years. However, how to improve the targeted delivery and cancer therapy efficacy is an important but challenging scientific issue. Herein, a drug delivery system using a probiotic as a carrier was developed for tumor-targeted photodynamic and sonodynamic synergistic therapy. Read More

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Effect of health warning labels on motivation towards energy-dense snack foods: Two experimental studies.

Appetite 2022 May 14:106084. Epub 2022 May 14.

Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Rd, CB2 8AH, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Elizabeth House, CB21 5EF, Cambridge, UK; Wellcome Trust-MRC Institute of Metabolic Science - Metabolic Research Laboratories, Addenbrooke's Hospital, CB2 0QQ, Cambridge, UK. Electronic address:

Health warning labels (HWLs) show promise in reducing motivation towards energy-dense snack foods. Understanding the underlying mechanisms could optimise their effectiveness. In two experimental studies in general population samples (Study 1 n = 90; Study 2 n = 1382), we compared the effects of HWLs and irrelevant aversive labels (IALs) on implicit (approach) motivation towards unhealthy snacks, using an approach-avoidance task (Study 1), and a manikin task (Study 2). Read More

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Standard Genetic Code vs. Supersymmetry Genetic Code - Alphabetical table vs. physicochemical table.

Biosystems 2022 May 14:104695. Epub 2022 May 14.

Croatian Academy of Sciences and Arts, 10000, Zagreb, Croatia; Department of Physics, Faculty of Science, University of Zagreb, Croatia.

The fundamental role of symmetry in the genetic code is to decrease disorder between codons and to preserve the integrity of system. The Standard Genetic Code (SGC) table is structured alphabetically in a horizontal and vertical array of U-C-A-G bases only with aesthetic symmetry. We postulate "the symmetry theory of genetic code" which is based on the unique physicochemical purine - pyrimidine symmetry net between codons of our Supersymmetry genetic code (SSyGC) table. Read More

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Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment.

Neurobiol Dis 2022 May 14:105750. Epub 2022 May 14.

Department of Neurology, Zhujiang Hospital of Southern Medical University, Gongye Road 253, Guangzhou, Guangdong 510282, China; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, China. Electronic address:

Cerebral small vessel disease (CSVD) is a generic term used for intracranial vascular disorders caused by the structural changes of cerebral microvessels, including the small arteries, arterioles, capillaries and venules. CSVD exhibits various neuroimaging features and is associated clinical characteristics. Although CSVD is recognized as the leading cause of vascular cognitive impairment (VCI), the underlying mechanism(s) remains elusive. Read More

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Light-triggered Photodynamic Nanomedicines for Overcoming Localized Therapeutic Efficacy in Cancer Treatment.

Adv Drug Deliv Rev 2022 May 14:114344. Epub 2022 May 14.

KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea; Medicinal Materials Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea. Electronic address:

Photodynamic nanomedicines have significantly enhanced the therapeutic efficacy of photosensitizers (PSs) by overcoming critical limitations of PSs such as poor water solubility and low tumor accumulation. Furthermore, functional photodynamic nanomedicines have enabled overcoming oxygen depletion during photodynamic therapy (PDT) and tissue light penetration limitation by supplying oxygen or upconverting light in targeted tumor tissues, resulting in providing the potential to overcome biological therapeutic barriers of PDT. Nevertheless, their localized therapeutic effects still remain a huddle for the effective treatment of metastatic- or recurrent tumors. Read More

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RT-Cloud: A Cloud-based Software Framework to Simplify and Standardize Real-Time fMRI.

Neuroimage 2022 May 14:119295. Epub 2022 May 14.

Princeton Neuroscience Institute, Princeton University, Princeton, NJ; Department of Psychology, Princeton University, Princeton, NJ. Electronic address:

Real-time fMRI (RT-fMRI) neurofeedback has been shown to be effective in treating neuropsychiatric disorders and holds tremendous promise for future breakthroughs, both with regard to basic science and clinical applications. However, the prevalence of its use has been hampered by computing hardware requirements, the complexity of setting up and running an experiment, and a lack of standards that would foster collaboration. To address these issues, we have developed RT-Cloud (https://github. Read More

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Hic12, a novel acidic matrix protein promotes the transformation of calcite into vaterite in Hyriopsis cumingii.

Comp Biochem Physiol B Biochem Mol Biol 2022 May 14:110755. Epub 2022 May 14.

School of Life Science, Shaoxing University, Huancheng West Road 508, Shaoxing 312000, PR China. Electronic address:

Shell acidic matrix proteins are widely considered to be essential for shell formation given their low affinity and high loading for calcium ion. In the present study, a novel matrix protein, hic12, was isolated from the mantle of Hyriopsis cumingii. High expression in tissue and positive signals with in situ hybridization were detected in the mantle center and mantle pallium, indicating that hic12 mainly participated in the biomineralization of the shell nacreous layer. Read More

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Transcriptomic characterization of Atlantic salmon (Salmo salar) head kidney following administration of Aeromonas salmonicida subsp. masoucida vaccine.

Fish Shellfish Immunol 2022 May 14. Epub 2022 May 14.

School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, China. Electronic address:

Atlantic salmon is one of the most famous and economically important fish species globally. However, bacterial diseases constantly constrain salmon aquaculture. Thereinto, Aeromonas salmonicida subsp. Read More

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Identification of reactive oxygen species modulator 1 (Romo 1) from black rockfish (Sebastes schlegelii) and deciphering its molecular characteristics, immune responses, oxidative stress modulation, and wound healing properties.

Fish Shellfish Immunol 2022 May 14. Epub 2022 May 14.

Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju, 63333, Republic of Korea. Electronic address:

Reactive oxygen species modulator 1 (Romo1) is a mitochondrial inner membrane protein that induces mitochondrial reactive oxygen species (ROS) generation. In this study, we identified the Romo1 homolog from the black rockfish (Sebastes schlegelii), named it as SsRomo1, and characterized it at the molecular as well as functional levels. An open reading frame consisting of 240 bp was identified in the SsRomo1 complementary DNA (cDNA) sequence that encodes a 79 amino acid-long polypeptide with a molecular weight of 8,293 Da and a theoretical isoelectric point (pI) of 9. Read More

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The effect of adding Bacillus amyloliquefaciens LSG2-8 in diets on the growth, immune function, antioxidant capacity, and disease resistance of Rhynchocypris lagowskii.

Fish Shellfish Immunol 2022 May 14. Epub 2022 May 14.

College of Animal Science and Technology, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, Jilin Agricultural University, Changchun 130118, China; College of Life Science, Jilin Agricultural University, Changchun, China; Tonghua Normal University, College of Life Science, Jilin, Tonghua, 134001, China. Electronic address:

The purpose of this study was to investigate the effect of Bacillus amyloliquefaciens LSG2-8 on the growth performance, immune function, antioxidant capacity, and disease resistance of Rhynchocypris lagowskii. Fish were fed with the feed containing five levels such as 0, 1.0 × 10, 1. Read More

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T-lymphocyte Tyrosine Hydroxylase Regulates T17 T-lymphocytes during Repeated Social Defeat Stress.

Brain Behav Immun 2022 May 14. Epub 2022 May 14.

Department of Psychiatry and Behavioral Sciences, Texas A&M Health Science Center, College Station, Texas, United States; Department of Medical Physiology, Texas A&M Health Science Center, College Station, Texas, United States. Electronic address:

Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder which results in deleterious changes to psychological and physical health. Patients with PTSD are especially susceptible to life-threatening co-morbid inflammation-driven pathologies, such as autoimmunity, while also demonstrating increased T-helper 17 (T17) lymphocyte-driven inflammation. While the exact mechanism of this increased inflammation is unknown, overactivity of the sympathetic nervous system is a hallmark of PTSD. Read More

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Traditional uses, phytochemistry, transformation of ingredients and pharmacology of the dried seeds of Raphanus sativus L. (Raphani Semen), A comprehensive review.

J Ethnopharmacol 2022 May 14:115387. Epub 2022 May 14.

College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address:

Ethnopharmacological Relevance: Raphani Semen (Lai Fu-zi in Chinese, RS), the dried seeds of Raphanus sativus L., is a traditional Chinese herbal medicine. RS has long been used for eliminating bloating and digestion, antitussive, expectorant and anti-asthmatic in clinical treatment of traditional Chinese medicine. Read More

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Trivalent arsenic impairs the effector response of human CD4 and CD8 T cells to influenza A virus ex vivo.

Food Chem Toxicol 2022 May 14:113122. Epub 2022 May 14.

Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, 48824, United States; Institute for Integrated Toxicology, Michigan State University, East Lansing, MI, 48824, United States; Cell and Molecular Biology Program, Michigan State University, East Lansing, MI, 48824, United States; Applied Immunology Center for Education and Research, Michigan State University, East Lansing, MI, 48824, United States. Electronic address:

Arsenic is a persistent environmental contaminant that humans are exposed to primarily through contaminated water supplies. Arsenic has been shown to have numerous immunomodulatory effects, including deleterious effects on T cell function. However, the effect of arsenic on human T cell function in the context of influenza infection remains poorly characterized. Read More

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Cellulose- and xylan-degrading yeasts: Enzymes, applications and biotechnological potential.

Biotechnol Adv 2022 May 14:107981. Epub 2022 May 14.

Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.

Microbes and their carbohydrate-active enzymes are central for depolymerization of complex lignocellulosic polysaccharides in the global carbon cycle. Their unique abilities to degrade and ferment carbohydrates are also utilized in many industrial processes such as baking, brewing and production of biofuels and drugs. Effective degradation and utilization of cellulose and hemicelluloses is important for the shift towards green bioeconomy, and requires microbes equipped with proper sets of carbohydrate-active enzymes (CAZymes). Read More

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Development of green and sustainable smart biochromic and therapeutic bandage using red cabbage (Brassica oleracea L. Var. capitata) extract encapsulated into alginate nanoparticles.

Int J Biol Macromol 2022 May 14. Epub 2022 May 14.

Department of Chemistry, Faculty of Applied Science, Umm Al Qura University, Makkah 24230, Saudi Arabia; Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, 35516, Egypt. Electronic address:

Novel multifunctional wound dressing with the ability to protect, cure and sense the healing process, was developed. Red-cabbage extract has been reported to exhibit bioactive compounds with the ability to function as antioxidant, antiinflammatory, anticancer, antibacterial, antifungal, and antiviral agent, as well as a natural pH-sensory chromophoric material. An anthocyanin extract was prepared from Red-cabbage (Brassica oleracea L. Read More

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Evaluation of Trefoil Factor 3 as a Non-Invasive Biomarker of Gastric Intestinal Metaplasia and Gastric Cancer in a High-Risk Population.

Gastroenterol Hepatol 2022 May 14. Epub 2022 May 14.

Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; Operative Group of Chilean Association of Digestive Endoscopy (ACHED), Santiago, Chile.

Background: Adenocarcinoma is preceded by chronic atrophic gastritis, gastric intestinal metaplasia and dysplasia. Trefoil factor 3 (TFF3) is a peptide secreted by goblet cells, which is abundantly present in intestinal metaplasia.

Aim: To evaluate the utility of serum TFF3 as a non-invasive biomarker for the diagnosis of intestinal metaplasia and gastric cancer. Read More

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Synthesis of Novel Immunomodulatory 1,4-Disubstituted Bis-1,2,3-triazoles by Using Click Chemistry and Their Intracellular Mechanism of Action.

Bioorg Med Chem Lett 2022 May 14:128800. Epub 2022 May 14.

Department of Biotechnology, Faculty of Arts and Science, Mersin University, TR-33440, Mersin, Turkey; Mersin University Biotechnology Research and Application Center, Mersin University, TR-33440, Mersin, Turkey.

In this study, six new 1,4-disubstituted bis-1,2,3-triazole compounds, N,N'-(1,2-phenylene)bis(2-(4-R-1H-1,2,3-triazol-1-yl)acetamide), were synthesized with high yield (88-96%) by using click chemistry and their molecular structures were characterized by using NMR, FT-IR, HRMS and elemental analysis techniques. Previous studies suggest anti-inflammatory and analgesic activities for different 1,2,3-triazole derivatives and in the light of those studies we aimed to examine these novel derivatives immunomodulatory activities on the mammalian macrophages. Pro-inflammatory cytokines (TNF, IL6, GMCSF and IL12p40) secretion levels were tested in the presence of bis-1,2,3-triazole compounds when the macrophages were activated with LPS. Read More

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Comparison of three zinc binding groups for HDAC inhibitors - A potency, selectivity and enzymatic kinetics study.

Bioorg Med Chem Lett 2022 May 14:128797. Epub 2022 May 14.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China. Electronic address:

Hydroxamic acid and benzamide are the most commonly used zinc binding group (ZBG) for HDAC inhibitors both in clinic and pre-clinic. Recently, we discovered several analogs of new type HDAC inhibitors with hydrazide as ZBG. Representative compounds displayed high potency, class I HDAC selectivity and excellent pharmacokinetics profile. Read More

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WILSON'S DISEASE - NEVER TOO LATE.

Am J Med 2022 May 14. Epub 2022 May 14.

Wellcome-MRC Institute of Metabolic Science, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, UK.

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Long-term cardiac monitoring after embolic stroke of undetermined source. Search longer - look harder.

Am J Med 2022 May 14. Epub 2022 May 14.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. Electronic address:

Embolic stroke of undetermined source (ESUS) represents a heterogeneous subgroup of patients with cryptogenic stroke, in which despite an extensive diagnostic work-up the cause of stroke remains uncertain. Identifying covert atrial fibrillation among ESUS patients remains challenging. The increasing use of cardiac implanted electronic devices (CIED), such as pacemakers, implantable defibrillators and implantable loop recorders (ILR), has provided important information on the burden of subclinical atrial fibrillation. Read More

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Alcohol Consumption and Cardiovascular Health.

Am J Med 2022 May 14. Epub 2022 May 14.

John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, USA.

Introduction: Studies evaluating alcohol consumption and cardiovascular diseases have shown inconsistent results.

Methods: We performed a systematic review of peer-reviewed publications from an extensive query of Ovid MEDLINE, Ovid Embase, Ovid Cochrane Database of Systematic Reviews, Scopus, and Web of Science from database inception to March 2022 for all studies that reported the association between alcohol consumption in terms of quantity (daily or weekly amounts) and type of beverage (wine, beer or spirit) and cardiovascular disease events.

Results: The study population included a total of 1,579,435 individuals based on 56 cohorts from several countries. Read More

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Influence of microplastics on the bioconcentration of organic contaminants in fish: Is the "Trojan horse" effect a matter of concern?

Environ Pollut 2022 May 14:119473. Epub 2022 May 14.

IMDEA Water Institute, Science and Technology Campus of the University of Alcalá, Avda. Punto Com 2, 28805, Alcalá de Henares, Madrid, Spain.

Microplastics (MPs) have been shown to act as sorbent phases and thus carriers of organic chemicals in the aquatic environment. Therefore, concerns exist that MP ingestion increases the uptake and accumulation of organic chemicals by aquatic organisms. However, it is unclear if this pathway is relevant compared to other exposure pathways. Read More

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The association of airborne particulate matter and benzo[a]pyrene with the clinical course of COVID-19 in patients hospitalized in Poland.

Environ Pollut 2022 May 14:119469. Epub 2022 May 14.

Department of Infectious Diseases and Hepatology, Medical University of Białystok, 15-089, Białystok, Poland. Electronic address:

Air pollution can adversely affect the immune response and increase the severity of the viral disease. The present study aimed to explore the relationship between symptomatology, clinical course, and inflammation markers of adult patients with coronavirus disease 2019 (COVID-19) hospitalized in Poland (n = 4432) and air pollution levels, i.e. Read More

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Airborne particle number concentrations in China: A critical review.

Environ Pollut 2022 May 14:119470. Epub 2022 May 14.

Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, 219 Ningliu Road, Nanjing, 210044, China. Electronic address:

Particle number concentration (PNC) is an important parameter for evaluating the environmental health and climate effects of particulate matter (PM). A good understanding of PNC is essential to control atmospheric ultrafine particles (UFP) and protect public health. In this study, we reviewed the PNC studies in the literature aimed to gain a comprehensive understanding about the levels, trends, and sources of PNC in China. Read More

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Acute Respiratory Distress Syndrome after In-Hospital Cardiac Arrest.

Resuscitation 2022 May 14. Epub 2022 May 14.

Center for Resuscitation Science, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215; Department of Pulmonology and Critical Care, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467-2401.

Objective: Acute respiratory distress syndrome (ARDS) after out-of-hospital cardiac arrest is common and associated with worse outcomes. In the hospital setting, there are many potential risk factors for post-arrest ARDS, such as aspiration, sepsis, and shock. ARDS after in-hospital cardiac arrest (IHCA) has not been characterized. Read More

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Ketamine increases fronto-posterior functional connectivity during meta-perceptual confidence ratings.

Behav Brain Res 2022 May 14:113925. Epub 2022 May 14.

Department of Psychology, University of Bonn, Kaiser-Karl-Ring 9, 53111 Bonn, Germany. Electronic address:

Recent advances in the neuropsychopharmacology of metacognition indicate a constituent role of glutamate for the integrity of metamnestic processes. However, the extent to which previous results can be generalized across functional domains to characterize the relationship between glutamate and metacognition remains unclear. Here, in a randomized, double-blind, placebo-controlled, preregistered fMRI study, we tested the effects of a psychotomimetic dose (target plasma concentration 100ng/mL) of the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist ketamine on metacognition in a perceptual decision-making framework. Read More

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KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.

Exp Cell Res 2022 May 14:113208. Epub 2022 May 14.

Department of Laboratory Animal Science, China Medical University, Shenyang, 110122, Liaoning, PR China. Electronic address:

The significance of KDM2B in oncogenesis has been appreciated, but the mechanism behind is incompletely understood. In this work, we addressed its effects on the progression of non-small cell lung cancer (NSCLC). Overexpression of KDM2B was linked to dismal prognoses of NSCLC patients. Read More

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Melanoma spheroid-containing artificial dermis as an alternative approach to in vivo models.

Exp Cell Res 2022 May 14:113207. Epub 2022 May 14.

Department of Chemistry, Center of Nanotechnology and Tissue Engineering -Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, 14040-901, Brazil; School of Chemistry and Chemical Engineering, Anhui Key Laboratory of Modern Biomanufacturing, Anhui University, Hefei, 230601, China. Electronic address:

Melanoma spheroid-loaded 3D skin models allow for the study of crucial tumor characteristics and factors at a superior level because the neoplastic cells are integrated into essential human skin components, permitting tumor-skin model communication. We designed a melanoma-containing artificial dermis by inserting multicellular tumor spheroids from the metastatic phase of WM 1617 melanoma cells into an artificial dermis. We cultured multicellular melanoma spheroids by hanging drop method (250 cells per drop) with a size of 420 μm in diameter after incubation for 14 days. Read More

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Resting-state functional connectivity and spontaneous brain activity in early-onset bipolar disorder: A review of functional Magnetic Resonance Imaging studies.

J Affect Disord 2022 May 14. Epub 2022 May 14.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address:

Background: Early-onset bipolar disorder (BD) is a complex psychiatric illness characterized by mood swings, irritability and functional impairments. To improve our understanding of the pathophysiology of the disorder, we collected the existing resting-state functional Magnetic Resonance Imaging (rs-fMRI) studies exploring resting-state functional connectivity (rs-FC) and spontaneous activity alterations in children and adolescents with BD.

Methods: A search on PubMed, Web of Science and Scopus was conducted to identify all the relevant rs-fMRI investigations conducted in early-onset BD. Read More

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