2,324,752 results match your criteria Science New York N.Y.[Journal]


Describing How School-Based SLPs Determine Eligibility for Children with Speech Sound Disorders.

Semin Speech Lang 2019 Mar 22;40(2):105-112. Epub 2019 Feb 22.

Crane Center for Early Childhood Research and Policy, The Ohio State University, Columbus, Ohio.

The purpose of this study was to explore how school-based speech-language pathologists (SLPs) determine eligibility for children with speech sound disorders (SSDs). Presently, there is substantial variability nationwide with respect to if or how children with SSDs receive speech therapy in public schools. We report the results of a nation-wide survey of school-based SLPs, which further underscore this variability. Read More

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http://dx.doi.org/10.1055/s-0039-1677761DOI Listing

Optimising the biocompatibility of 3D printed photopolymer constructs in vitro and in vivo.

Biomed Mater 2019 Feb 22. Epub 2019 Feb 22.

Department of Surgery, University of Melbourne Faculty of Medicine Dentistry and Health Sciences, Melbourne, Victoria, AUSTRALIA.

3D printing is a rapid and accessible fabrication technology that engenders creative custom design solutions for cell scaffolds, perfusion systems and cell culture systems for tissue engineering. Critical to its success is the biocompatibility of the materials used, which should allow long-term tissue culture without affecting cell viability or inducing an inflammatory response for in vitro and in vivo applications. Polyjet 3D printers offer arguably the highest resolution with the fewest design constraints of any commercially available 3D printing systems. Read More

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http://dx.doi.org/10.1088/1748-605X/ab09c4DOI Listing
February 2019

Molecular beam epitaxial growth of dilute nitride GaNAs and GaInNAs nanowires.

Nanotechnology 2019 Feb 22. Epub 2019 Feb 22.

Ehime University Faculty of Engineering Graduate School of Science and Engineering, Matsuyama, Ehime, JAPAN.

We report the growth of dilute nitride GaNAs and GaInNAs core-multishell nanowires by plasma-assisted molecular beam epitaxy. Using constituent Ga-induced vapor-liquid-solid growth, these nanowires were grown on Si(111) and silicon on insulator (SOI) substrates. The GaNAs shell nominally contains 0%, 2%, and 3% nitrogen. Read More

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http://dx.doi.org/10.1088/1361-6528/ab0974DOI Listing
February 2019

Epidermal growth factor-nanoparticle conjugates change the activity from anti-apoptotic to pro-apoptotic at membrane rafts.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

WPI Research Initiative for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan; Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. Electronic address:

The proliferation epidermal growth factor (EGF) is known to acquire contradictory apoptotic activities upon conjugation with gold nanoparticles (GNPs) through hitherto unknown mechanisms. Here, we identified an essential role of membrane rafts in the drastic activity switching of EGF-GNPs through the following intracellular signaling. 1) In contrast to the rapid diffusion of activated EGF receptor after the soluble EGF stimulation, the receptor is confined within membrane rafts upon binding to the EGF-GNPs. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.026DOI Listing
February 2019

Unusual relapse of primary central nervous system lymphoma both inside and outside central nervous system in a patient with ventriculoperitoneal shunt: a case report.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Lymphoma Division, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, Guangdong, China. Electronic address:

Background: Relapse of primary central nervous system lymphoma (PCNSL) occurs primarily at the initial site, relapse outside central nervous system is very rare.

Case Description: We present the case of a 62-year-old immuno-competent man who underwent a stereotactic biopsy to diagnose PCNSL and subsequent placement of ventriculoperitoneal shunt for symptom relief in November 2012. He got complete remission after 6 cycles of high dose methotrexate-based chemotherapy. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.277DOI Listing
February 2019

Transthoracic sonographic assessment of B-line scores during ascent to altitude among healthy trekkers.

Respir Physiol Neurobiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada.

Portable sonography-determined B-lines can indicate pulmonary interstitial edema. We sought to determine the incidence of subclinical pulmonary edema measured by sonographic B-lines among lowland trekkers ascending to high altitude in the Nepal Himalaya. Twenty healthy trekkers underwent portable sonographic examinations and arterial blood draws during ascent to 5160 m over ten days. Read More

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http://dx.doi.org/10.1016/j.resp.2019.02.005DOI Listing
February 2019

Vitamin D-binding protein-loaded PLGA nanoparticles suppress Alzheimer's disease-related pathology in 5XFAD mice.

Nanomedicine 2019 Feb 19. Epub 2019 Feb 19.

Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Republic of Korea. Electronic address:

The aggregation and accumulation of amyloid beta (Aβ) peptide is believed to be the primary cause of Alzheimer's disease (AD) pathogenesis. Vitamin D-binding protein (DBP) can attenuate Aβ aggregation and accumulation. A biocompatible polymer poly (-lactic acid-co-glycolic acid) (PLGA) can be loaded with therapeutic agents and control the rate of their release. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.004DOI Listing
February 2019

Gene cloning and expression of a partial sequence of Hirudomacin, an antimicrobial protein that is increased in leech (Hirudo nipponica Whitman) after a blood meal.

Comp Biochem Physiol B Biochem Mol Biol 2019 Feb 19. Epub 2019 Feb 19.

Institute of Chinese Medicinal Materials, Nanjing Agricultural University, Nanjing 210095, China.

The novel antimicrobial gene Hirudomacin (Hmc), with a 249-bp cDNA, encodes a mature protein of 61 amino acids and a 22-amino acid signal peptide. Hmc exhibits the highest similarity, at 90.1%, with macin family members found in the salivary gland of the leech Hirudo nipponica Whitman. Read More

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http://dx.doi.org/10.1016/j.cbpb.2019.02.005DOI Listing
February 2019

Towards a conceptual model of affective predictions in palliative care.

J Pain Symptom Manage 2019 Feb 19. Epub 2019 Feb 19.

National Cancer Institute, Bethesda, MD, USA.

Context: Being diagnosed with cancer often forces patients and families to make difficult medical decisions. How patients think they and others will feel in the future, termed affective predictions, may influence these decisions. These affective predictions are often biased, which may contribute to suboptimal care outcomes by influencing decisions related to palliative care and advance care planning. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.008DOI Listing
February 2019

Exploring the influence of the surface proteins on probiotic effects performed by Lactobacillus pentosus HC-2 using transcriptome analysis in Litopenaeus vannamei midgut.

Fish Shellfish Immunol 2019 Feb 19. Epub 2019 Feb 19.

CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao, 266071, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China; CAS Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, 266400, China. Electronic address:

In order to understand the mediation function of surface proteins in probiotic effects executed by Lactobacillus pentosus HC-2 in midgut of Litopenaeus vannamei, the immune and digestion related enzymes and the transcriptome expression were analyzed after shrimp fed with normal HC-2 or with stripped surface proteins HC-2 by lithium chloride (LiCl) treatment. The results showed that the shrimp fed with normal HC-2 produced much higher immune and digestion related enzymes than the control group or LiCl-treated HC-2 group to defense the Vibrio parahaemolyticus E1 infection. We obtained total over 275,099 unigenes from L. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.02.027DOI Listing
February 2019

Diurnal rhythm and pathogens induced expression of toll-like receptor 9 (TLR9) in Pelteobagrus vachellii.

Fish Shellfish Immunol 2019 Feb 19. Epub 2019 Feb 19.

College of Life Science, Neijiang Normal University, Key Laboratory of Sichuan Province for Fishes Conservation and Utilization in the Upper Reaches of the Yangtze River, Neijiang, 641000, PR China.

Toll-like receptor 9 (TLR9) is activated by bacterial DNA and induces the production of inflammatory cytokines. In this study, the darkbarbel catfish Pelteobagrus vachellii TLR9 cDNA was cloned and sequenced. The daily expression pattern of TLR9 mRNA was investigated in various tissues. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.02.038DOI Listing
February 2019

Accuracy and usability of single-lead ECG from smartphones - A clinical study.

Indian Pacing Electrophysiol J 2019 Feb 19. Epub 2019 Feb 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.

Background: Several wireless ECG devices are commercially available for possible screening, monitoring and diagnosis of rhythms. The field is rapidly expanding, and some devices have demonstrated acceptable qualities. The objective was to evaluate the accuracy, usability and diagnostic capabilities of smartphone ECG (spECG) in both patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.ipej.2019.02.006DOI Listing
February 2019

Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address:

Dihydrotanshinone (DHT), one of the major ingredients of Salvia miltiorrhiza Bunge (Danshen), displays many bioactivities. However, the activity and underlying mechanism of DHT in anti-inflammation have not yet been elucidated. In this study, we investigated the anti-inflammatory activity and molecular mechanism of action of DHT both in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.017DOI Listing
February 2019

The effect of probiotic and synbiotic supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: a systematic review and meta-analysis of randomized controlled trials.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Shipping warehouse No. 5, Beijing, 100700, China. Electronic address:

The role of gut microbiota in the management of diabetes has been shown. Several current trials are investigating the effect of probiotics and prebiotics, which are widely used to modulate intestinal microbiota, on inflammatory factors and biomarkers of oxidative stress in diabetic patients; however, their findings are controversial. The aim of the current meta-analysis was to evaluate the effects of probiotic and synbiotic supplementation on levels of serum high-sensitivity C-reactive protein (hs-CRP) and biomarkers of oxidative stress in diabetic patients. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.016DOI Listing
February 2019

Possible clues for camptothecin biosynthesis from the metabolites in camptothecin-producing plants.

Fitoterapia 2019 Feb 19. Epub 2019 Feb 19.

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address:

The plant derived camptothecin (CPT) is a pentacyclic pyrroloquinoline alkaloid with unique antitumor activity. Successive discoveries of new CPT-producing plants occurred in recent years due to market demands. The scattered distribution among angiosperms drew researchers' attention. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.02.014DOI Listing
February 2019

Knockout of Wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart.

Gene 2019 Feb 19. Epub 2019 Feb 19.

Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430081, PR China. Electronic address:

WDR1 is a major cofactor of the actin depolymerizing factor (ADF)/cofilin, accelerating ADF/cofilin-mediated actin disassembly. We had previously showed that WDR1-mediated actin dynamics is required for postnatal myocardial growth and adult myocardial maintenance in mice, in which the detailed phenotypes of adult cardiomyocyte-specific Wdr1 deletion mice had not been analyzed. In this study, we systematically analyzed the role of Wdr1 in adult mouse heart. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.023DOI Listing
February 2019

Dynamic oligomerization of hRAGE's transmembrane and cytoplasmic domains within SDS micelles.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Department of Biological Sciences (Biochemistry Program), Faculty of Science, Kuwait University, P.O. Box 5969, 13060, Kuwait.

The human Receptor for Advanced Glycation End Products (hRAGE) is a pattern recognition receptor implicated in inflammation and adhesion. It is involved in both innate and adaptive immunity. Its aberrant signaling is tied to the pathogenesis of diabetic complications, neurodegenerative disorders, and chronic inflammatory responses. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.108DOI Listing
February 2019

Investigation the interaction between procyanidin dimer and α-glucosidase: Spectroscopic analyses and molecular docking simulation.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China. Electronic address:

Procyanidins are reported to inhibit α-glucosidase, which may be a useful attribute for developing functional foods that control post-prandial blood sugar levels. At present, the nature of the molecular interaction between procyanidins and α-glucosidase is poorly understood. In this study, spectroscopic analyses and computer simulations were used to investigate the interactions between α-glucosidase and B-type procyanidin dimer (BPD). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.105DOI Listing
February 2019

Comparison and structural characterization of polysaccharides from natural and artificial Se-enriched green tea.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Institute of Food Engineering, College of Life & Environment Science, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, PR China. Electronic address:

Se-enriched green tea has been widely used as a functional food and disease prevention. In this study, two kinds of homogeneous polysaccharides namely ASe-TPS2 and NSe-TPS2 were obtained from artificial and natural Se-enriched teas with the molecular weights of 6.73 × 10 Da and 2. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.102DOI Listing
February 2019

Truncation of κ‑carrageenase for higher κ‑carrageenan oligosaccharides yield with improved enzymatic characteristics.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

College of Biological Science and Engineering, Fujian Provincial Key Laboratory of Marine Enzyme Engineering, Fuzhou University, China, 350108. Electronic address:

Carrageenase is useful for preparation of carrageenan oligosaccharides, which have significant bioactivity. We expressed a κ‑carrageenase gene from Zobellia sp. ZL-4 in full-length (κ-ZL-4) or after truncation of the carbohydrate binding module and the Type-IX secretion module (κ-ZL-4-GH16). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.109DOI Listing
February 2019

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

J Hepatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea; KU Open Innovation Center, Konkuk University, Seoul, Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Korea. Electronic address:

Background & Aims: Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.006DOI Listing
February 2019

Multicellular systems biology: quantifying cellular patterning and function in plant organs using network science.

Authors:
George W Bassel

Mol Plant 2019 Feb 19. Epub 2019 Feb 19.

School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address:

Organ function is at least partially shaped and constrained by the organization of their constituent cells. Extensive investigation has revealed mechanisms explaining how these patterns are generated, with less being known about their functional relevance. In this paper, a methodology to discretize and quantitatively analyze cellular patterning is described. Read More

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http://dx.doi.org/10.1016/j.molp.2019.02.004DOI Listing
February 2019

Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells.

Anaerobe 2019 Feb 19. Epub 2019 Feb 19.

Microhealth Group, Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias - Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Villaviciosa, Asturias, Spain. Electronic address:

The toll-like receptors involved in recognition of the exopolysaccharide produced by two isogenic, ropy and non-ropy, Bifidobacterium animalis subsp. lactis strains were investigated. Both strains interact with human embryonic kidney (HEK)-293 cells via TLR2, whereas purified EPSs specifically stimulate TLR4 regardless their molar mass. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.02.014DOI Listing
February 2019

Influence of traditionally used Nepalese plants on wound healing and immunological properties using primary human cells in vitro.

J Ethnopharmacol 2019 Feb 19. Epub 2019 Feb 19.

Centre for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Faculty of Medicine, University of Freiburg, Breisacher Straße 115 B, 79106 Freiburg, Germany. Electronic address:

Ethnopharmacological Relevance: The improvement of wound healing has always been an important issue for both ethnopharmacological and modern medical research. In this study, we used state-of-the-art methods to investigate extracts of plants used traditionally in Nepal for more than 1,000 years to treat inflammatory skin injuries.

Aim Of The Study: We focused on the potential of the plant extracts to ameliorate wound healing and to influence immune modulatory properties. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.034DOI Listing
February 2019

Effectiveness and Core Components of Infection Prevention and Control Programmes in Long-term Care Facilities: A Systematic Review.

J Hosp Infect 2019 Feb 19. Epub 2019 Feb 19.

The Research Institute of Nursing Science, College of Nursing, Seoul National University, Seoul, Republic of Korea. Electronic address:

Background: Infection prevention and control (IPC) is a measure to prevent healthcare-associated infections in healthcare settings. There is limited evidence of the effectiveness of IPC programmes in long-term care facilities (LTCFs).

Aim: The purpose of this systematic review was to review and analyse the effectiveness and the components of IPC programmes in LTCFs for older adults. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.02.008DOI Listing
February 2019

Spatiotemporal Models in Biology and the Health Sciences.

Biosystems 2019 Feb 19. Epub 2019 Feb 19.

Institute of Mathematics and Physics, UTP University of Science and Technology, PL-85796 Bydgoszcz, Poland.

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http://dx.doi.org/10.1016/j.biosystems.2019.02.006DOI Listing
February 2019

Enrichment-induced differences in methamphetamine drug discrimination in male rats.

Pharmacol Biochem Behav 2019 Feb 19. Epub 2019 Feb 19.

Creighton University, Department of Psychological Science, United States of America. Electronic address:

Rats raised in an enriched environment show a decrease in sensitivity to the subjective effects of the psychostimulant d-amphetamine. The purpose of the present study was to determine if environmental enrichment during development alters the subjective effects of the more commonly abused drug methamphetamine. Male Sprague-Dawley rats were raised in either an enriched (EC) or an isolated condition (IC). Read More

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http://dx.doi.org/10.1016/j.pbb.2019.02.008DOI Listing
February 2019

Slow dynamics in microcolumnar gap junction network of developing neocortical pyramidal neurons.

Neuroscience 2019 Feb 19. Epub 2019 Feb 19.

RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan. Electronic address:

Gap junctions mediate electrical coupling between neurons and modulate their firing activity. In mouse neocortical layer 5, the major types of pyramidal neurons organize into cell type-specific microcolumns that exhibit modular neuronal activity. During cortical development, microcolumn neurons are electrically coupled in a cell type-specific manner at the stage of synaptogenesis, forming a dense network of gap junctions. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.02.013DOI Listing
February 2019

Treatment with the glutamate modulator riluzole prevents early life stress-induced cognitive deficits and impairments in synaptic plasticity in APPswe/PS1dE9 mice.

Neuropharmacology 2019 Feb 19. Epub 2019 Feb 19.

Brain Plasticity Group, SILS-CNS, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands. Electronic address:

Background: Environmental factors like stress affect age-related cognitive deficits and promote Alzheimer's disease (AD)-related pathology in mice. Excess glutamate has been proposed as a possible mediator underlying these effects in the hippocampus, a vulnerable brain region implicated in learning and memory.

Methods: Here, we examined a) whether stress applied during a sensitive developmental period early in life affects later synaptic plasticity, learning and memory and plaque load in the APPswe/PS1dE9 mouse model for Alzheimer's disease and b) whether these effects could be rescued using long-term treatment with the glutamate modulator riluzole. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.023DOI Listing
February 2019

Reductively cleavable polymer-drug conjugates based on dendritic polyglycerol sulfate and monomethyl auristatin E as anticancer drugs.

J Control Release 2019 Feb 19. Epub 2019 Feb 19.

Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany. Electronic address:

Stimuli-responsive polymer-drug conjugates (PDCs) provide promising approaches in anticancer treatment. Here, we report the synthesis and biological evaluation of PDCs made of the highly potent antimitotic agent monomethyl auristatin E conjugated to dendritic polyglycerol and dendritic polyglycerol sulfate via a reductively cleavable, self-immolative disulfide linker. Cell viability assays with the human cancer cell lines A549 (lung carcinoma) and HeLa (cervix carcinoma) revealed that the drug's cytotoxicity was reduced by conjugation to the polymers, with the sulfated conjugates being more effective than the non-sulfated ones. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.01.035DOI Listing
February 2019

Psychopathology and extrapyramidal side effects in smoking and non-smoking patients with schizophrenia: Systematic review and meta-analysis of comparative studies.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Feb 19. Epub 2019 Feb 19.

Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China. Electronic address:

The association between smoking and psychopathology and extrapyramidal symptoms in schizophrenia has been controversial. This systematic review and meta-analysis compared psychopathology and extrapyramidal symptoms between smoking and non-smoking schizophrenia patients. The PubMed, EMBASE, PsycINFO, Cochrane Library, and Web of Science databases were independently and systematically searched by two researchers to identify relevant articles. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.02.011DOI Listing
February 2019

Cerebellar transcranial direct current stimulation modulates the effect of cerebellar transcranial magnetic stimulation on the excitability of spinal reflex.

Neurosci Res 2019 Feb 19. Epub 2019 Feb 19.

Faculty of Health Science, Kio University, 4-2-2 Umami-naka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan; Neurorehabilitation Research Center of Kio University, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan. Electronic address:

Cerebellar transcranial magnetic stimulation (C-TMS) facilitates the ipsilateral soleus H-reflex, which reflects the excitability of the spinal motoneuron pool. This study aimed to investigate whether this facilitation of the spinal motoneuron pool excitability by C-TMS is affected by cerebellar transcranial direct current stimulation (ctDCS) in a polarity-specific manner. Eleven healthy adults participated in this study. Read More

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http://dx.doi.org/10.1016/j.neures.2019.01.012DOI Listing
February 2019

Diagnosis and Surgical Outcomes of Facial Asymmetry According to the Occlusal Cant and Menton Deviation.

J Oral Maxillofac Surg 2019 Jan 29. Epub 2019 Jan 29.

Associate Professor, Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, Republic of Korea. Electronic address:

Purpose: Morphologic differences and surgical outcomes were compared between the ipsilateral type of facial asymmetry, in which the menton deviates to the side of the upward frontal occlusal plane (FOP) cant (FOP), and the contralateral type, in which the menton deviates to the side of the downward FOP cant (FOP), by using cone beam computed tomography (CBCT) images.

Materials And Methods: This retrospective study included consecutive patients with skeletal Class III malocclusion and facial asymmetry who had undergone bimaxillary orthognathic surgery and serial CBCT before, 1 month after, and 1 year after surgery. CBCT images were reconstructed and analyzed for predictor (group and timing) and outcome (CBCT measurements over time) variables. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.028DOI Listing
January 2019

β-Catenin and yes-associated protein 1 cooperate in hepatoblastoma pathogenesis.

Am J Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Gynecology, Shiyan Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan, China. Electronic address:

Hepatoblastoma (HB), the most common pediatric primary liver neoplasm, show nuclear localization of β-catenin and yes-associated protein1 (YAP1) in almost 80% of the cases. Co-expression of constitutively active S127A-YAP1 and ΔN90 deletion-mutant-β-catenin (YAP1-ΔN90-β-catenin) causes HB in mice. Since heterogeneity in downstream signaling is being identified owing to mutational differences even in β-catenin gene alone, we investigated if co-expression of point-mutants of β-catenin (S33Y or S45Y) with S127A-YAP1 led to similar tumors as YAP1-ΔN90-β-catenin. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.02.002DOI Listing
February 2019

TEA domain transcription factor 4 (TEAD4) is the major mediator of Yap oncogenic activity in mouse and human hepatoblastoma.

Am J Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA. Electronic address:

Hepatoblastoma (HB) is the most common type of pediatric liver cancer. Activation of Yes-associated protein (YAP) has been implicated in HB molecular pathogenesis. The transcriptional co-activator Yap regulates downstream gene expression through interaction with the TEA domain (TEAD) proteins. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.016DOI Listing
February 2019

Quality by Design Driven Process Development of Cell Culture in Bioreactor for the Production of Foot-and-Mouth Veterinary Vaccine.

J Pharm Sci 2019 Feb 19. Epub 2019 Feb 19.

National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; Jiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China. Electronic address:

Quality by design (QbD) principle has been established as a guideline to emphasize the understanding of the relationship of product quality with process control. Vaccine product have characteristics of security and high efficiency, but it also has features like complexity and rigorous regulatory for production. This case study describes an example of QbD driven process development for manufacturing a veterinary vaccine produced with baby hamster kidney-21 (BHK-21) cells. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.02.004DOI Listing
February 2019

Innovation in Chemistry, Manufacturing, and Controls - A Regulatory Perspective From Industry.

J Pharm Sci 2019 Feb 19. Epub 2019 Feb 19.

Regulatory Affairs CMC, Amgen Inc., Thousand Oaks, CA, USA.

This review describes the landscape of novel modalities such as cell and gene therapies, viruses, other novel biologics, oligomers, and emerging technologies, including modern analytics. We summarize the regulatory history and recent landmark developments in some major markets and examine specific chemistry, manufacturing, and controls (CMC) challenges, including suggestions for exploration of potential science-based approaches in support of regulatory strategy development from an industry perspective. Additionally, we evaluate the economic factors contributing to patient access to innovation and discuss the impact of regulation. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.02.007DOI Listing
February 2019

Predictive Factors for the Rate of Visual Field Progression in the Advanced Imaging for Glaucoma Study.

Am J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Casey Eye Institute, Oregon Health & Science University. Electronic address:

Purpose: To investigate predictive factors associated with the rate of visual field (VF) loss in open-angle glaucoma.

Design: Prospective multicenter cohort study.

Methods: Perimetric glaucoma patients of the Advanced Imaging for Glaucoma study were selected for analysis if they had 9 completed visits. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.015DOI Listing
February 2019

FXR Regulates Intestinal Cancer Stem Cell Proliferation.

Cell 2019 Feb;176(5):1098-1112.e18

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

Increased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive malignant transformations in Lgr5-expressing (Lgr5) cancer stem cells and promote an adenoma-to-adenocarcinoma progression. Mechanistically, we show that BAs that antagonize intestinal farnesoid X receptor (FXR) function, including tauro-β-muricholic acid (T-βMCA) and deoxycholic acid (DCA), induce proliferation and DNA damage in Lgr5 cells. Read More

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http://dx.doi.org/10.1016/j.cell.2019.01.036DOI Listing
February 2019

Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation.

Cell 2019 Feb;176(5):1014-1025.e12

Institute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA. Electronic address:

Bioactive molecules can pass between microbiota and host to influence host cellular functions. However, general principles of interspecies communication have not been discovered. We show here in C. Read More

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http://dx.doi.org/10.1016/j.cell.2019.01.037DOI Listing
February 2019

Is Wii-based motor training better than task-specific matched training for children with developmental coordination disorder? A randomized controlled trial.

Disabil Rehabil 2019 Feb 22:1-10. Epub 2019 Feb 22.

a Department of Physical Therapy , Universidade Federal de São Carlos , São São Paulo , Brazil.

Purpose: To evaluate in children with developmental coordination disorder (DCD) the effects of Wii-training compared with task-specific matched training (TST).

Material And Methods: A randomized controlled trial (RCT) was conducted with 32 children having DCD, aged 7-10 years. Children were randomly assigned to the Wii or task-specific training. Read More

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http://dx.doi.org/10.1080/09638288.2019.1572794DOI Listing
February 2019

The Developmental Characteristics for the Head Capsule Width of Monochamus alternatus (Coleoptera: Cerambycidae) Larvae and Determination of the Number of Instars.

J Insect Sci 2019 Jan;19(1)

Major of Plant Resources Science and Environment, College of Agriculture & Life Sciences, SARI, Jeju National University, Jeju, South Korea.

The objective of this study was to determine the number of instars of Monochamus alternatus Hope (Coleoptera: Cerambycidae) larvae by comparing their head capsule widths (HCW) published in previous studies, as well as additional laboratory experiments. Larvae of M. alternatus showed repeated molting in the laboratory. Read More

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http://dx.doi.org/10.1093/jisesa/iez010DOI Listing
January 2019

Male Bicyclus anynana Butterflies Choose Females on the Basis of Their Ventral UV-Reflective Eyespot Centers.

J Insect Sci 2019 Jan;19(1)

Department of Biological Sciences, National University of Singapore, Singapore.

Butterflies often use their dorsal and ventral wing color patterns for distinct signaling functions. Color patterns on hidden dorsal wing surfaces are often used in sexual signaling, while exposed ventral patterns are often used to ward off predator attacks. At rest, however, part of the ventral forewings are often hidden by the hindwings, allowing individuals to also use the patterns on this wing surface for sexual signaling. Read More

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http://dx.doi.org/10.1093/jisesa/iez014DOI Listing
January 2019

The metabolic abnormalities of chronic high dose glucocorticoids are not mediated by hypothalamic AgRP in male mice.

Endocrinology 2019 Feb 22. Epub 2019 Feb 22.

Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.

Glucocorticoids (Gcs) are potent and widely used medicines, but often cause metabolic side effects. A murine model of corticosterone (Cort) treatment results in increased hypothalamic expression of the melanocortin antagonist AgRP in parallel with obesity and hyperglycaemia. This study investigates how these adverse effects develop over time with particular emphasis on hypothalamic involvement. Read More

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http://dx.doi.org/10.1210/en.2019-00018DOI Listing
February 2019

Renal iron accumulation and oxidative injury with aging: effects of treatment with an iron chelator.

J Gerontol A Biol Sci Med Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Health and Human Physiology, The University of Iowa.

Dysregulation of iron metabolism in the kidney may contribute to age-related increases in renal oxidative stress and dysfunction. This study assessed the effects of short-term iron chelation on markers of iron status, oxidative stress, inflammation, and autophagy in the kidneys of old rats. Old Fischer 344 rats (24 mo) were treated with deferoxamine (DFO; 200 mg/kg, twice daily for 4. Read More

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http://dx.doi.org/10.1093/gerona/glz055DOI Listing
February 2019

Recurrence of depression in the perinatal period: Clinical features and associated vulnerability markers in an observational cohort.

PLoS One 2019 22;14(2):e0212964. Epub 2019 Feb 22.

The Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands.

Objective: Antidepressant medication is commonly used for the prevention of depression recurrence in the perinatal period, yet it is unknown what vulnerability markers may play a role in recurrence. The objective of the current study was to provide a descriptive overview of the associated characteristics of women who experienced a perinatal recurrence of depression despite ongoing antidepressant use, and further, to identify clinically measurable vulnerability markers associated with recurrence.

Methods: Eighty-five pregnant women with a history of depression who used antidepressants (e. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212964PLOS
February 2019

With open science gaining traction, do we need an Australasia PubMed Central (PMC)? A qualitative investigation.

PLoS One 2019 22;14(2):e0212843. Epub 2019 Feb 22.

Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.

Open biomedical repositories, such as PubMed Central (PMC), are a means to make research discoverable and permanently accessible. Assessing the potential interest of key stakeholders in an Australasia PubMed Central was the objective of this research. The investigation is novel, assisting in the development of open science infrastructure through its systematic analysis of the potential interest in, and viability of a biomedical repository for managing openly accessible research outputs for the Australasia region. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212843PLOS
February 2019

Joint specific power production in cycling: The effect of cadence and intensity.

PLoS One 2019 22;14(2):e0212781. Epub 2019 Feb 22.

Centre for Elite Sports Research, Department of Neuromedicine and Movement Science (INB), Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Background: The effect of cadence and work rate on the joint specific power production in cycling has previously been studied, but research has primarily focused on cadences above 60 rpm, without examining the effect of low cadence on joint contribution to power.

Purpose: Our purpose was to investigate joint specific power production in recreational and elite cyclists during low- and moderate cycling at a range of different cadences.

Methods: 18 male cyclists (30. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212781PLOS
February 2019

Welfare assessment of novel on-farm killing methods for poultry.

PLoS One 2019 22;14(2):e0212872. Epub 2019 Feb 22.

Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.

There is a need for novel mechanical devices for dispatching poultry on farm following the introduction of EU Regulation (EC) no. 1099/2009 On the Protection of Animals at the Time of Killing. We examined three novel mechanical killing devices: Modified Armadillo, Modified Rabbit Zinger, a novel mechanical cervical dislocation device; and traditional manual cervical dislocation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212872PLOS
February 2019

Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice.

PLoS One 2019 22;14(2):e0212856. Epub 2019 Feb 22.

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Antibiotic use during adolescence may result in dysbiosis-induced neuronal vulnerability both in the enteric nervous system (ENS) and central nervous system (CNS) contributing to the onset of chronic gastrointestinal disorders, such as irritable bowel syndrome (IBS), showing significant psychiatric comorbidity. Intestinal microbiota alterations during adolescence influence the expression of molecular factors involved in neuronal development in both the ENS and CNS. In this study, we have evaluated the expression of brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin-related kinase B (TrkB) in juvenile mice ENS and CNS, after a 2-week antibiotic (ABX) treatment. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212856PLOS
February 2019
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