1,972 results match your criteria Schnitzler Syndrome
Blood Cells Mol Dis 2018 Nov 16;75:1-10. Epub 2018 Nov 16.
Institut Curie, Site Saint-Cloud Hematology, Saint-Cloud, France. Electronic address:
Primary CNS lymphomas (PCNSL) are rare and poor prognosis diffuse large B-cell lymphomas. Because of the brain tumor environment and the restricted distribution of drugs in the CNS, specific PCNSL patient-derived orthotopic xenograft (PDOX) models are needed for preclinical research to improve the prognosis of PCNSL patients. PCNSL patient specimens (n = 6) were grafted in the caudate nucleus of immunodeficient nude mice with a 83% rate of success, while subcutaneous implantation in nude mice of human PCNSL sample did not generate lymphoma, supporting the role of the brain microenvironment in the PCNSL physiopathology. Read More
J Healthc Qual Res 2018 Nov - Dec;33(6):329-333. Epub 2018 Nov 27.
Servicio de Clínica Médica, Hospital Universitario Austral, Buenos Aires, Argentina.
Since January 2015 we have carried out a multiple-intervention strategic plan to reduce hospital stay in renal transplant recipients. The main objective of this study is to compare results of renal transplantation before and after putting into effect this plan in terms of graft and patient survival, readmissions and incidence of acute rejection during the first year post transplantation. In this retrospective analysis we included all patients 18 years of age or older who were transplanted at our institution. Read More
Aquat Toxicol 2018 Nov 15;206:102-104. Epub 2018 Nov 15.
Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover, Foundation, 25761, Büsum, Schleswig-Holstein, Germany.
A recent Science report predicted the global killer whale population to collapse due to PCB pollution. Here we present empirical evidence, which supports and extends the reports' statement. In 2016, a neonate male killer whale stranded on the German island of Sylt. Read More
Front Psychol 2018 30;9:2059. Epub 2018 Oct 30.
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
The sensory system constantly receives stimuli from the external world. To discriminate two stimuli correctly as two temporally distinct events, the temporal distance or stimulus onset asynchrony (SOA) between the two stimuli has to exceed a specific threshold. If the SOA between two stimuli is shorter than this specific threshold, the two stimuli will be perceptually fused and perceived as one single stimulus. Read More
Neuroimage Clin 2018 3;20:1246-1254. Epub 2018 Nov 3.
Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:
Objective: To investigate the spatial and temporal pattern of cortical responses evoked by deep brain stimulation (DBS) of the subthalamic nucleus (STN) and ventral intermediate nucleus of the thalamus (VIM).
Methods: We investigated 7 patients suffering from Essential tremor (ET) and 7 patients with Parkinson's Disease (PD) following the implantation of DBS electrodes (VIM for ET patients, STN for PD patients). Magnetoencephalography (MEG) was used to record cortical responses evoked by electric stimuli that were applied via the DBS electrode in trains of 5 Hz. Read More
Cereb Cortex 2018 Nov 12. Epub 2018 Nov 12.
Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Akinesia, a cardinal symptom of Parkinson's disease, has been linked to abnormal activation in putamen and posterior medial frontal cortex (pMFC). However, little is known whether clinical severity of akinesia is linked to dysfunctional connectivity of these regions. Using a seed-based approach, we here investigated resting-state functional connectivity (RSFC) of putamen, pMFC and primary motor cortex (M1) in 60 patients with Parkinson's disease on regular medication and 72 healthy controls. Read More
Mol Cancer Res 2018 Nov 6. Epub 2018 Nov 6.
Unité de Pharmacogénomique, Service de génétique, Institut Curie, Paris, France.
Numerous pangenomic studies identified protein-coding genes and signaling pathways involved in bladder carcinogenesis. However, noncoding somatic alterations remain unexplored. A recent study revealed a mutational hotspot in intron 6 of gene in 2. Read More
Ann Entomol Soc Am 2018 Oct 23;111(6):341-354. Epub 2018 Aug 23.
Forstzoologie und Entomologie, Albert-Ludwigs-Universität, Freiburg i.Br., Germany.
Pupae of numerous Papilionidae and Nymphalidae produce twitter sounds when wriggling in response to mechanical stimulation. The structural basis comprises distinct pairs of sound-producing organs (SPOs) located at intersegmental membranes of the abdomen. They differ-as the twitters do-in sampled taxa of Papilioninae, Epicaliini, and Heliconiini. Read More
J Eur Acad Dermatol Venereol 2018 Oct 25. Epub 2018 Oct 25.
Center for Chronic Pruritus Department of Dermatology, University Hospital Münster, Von-Esmarch-Str. 58, 48149, Münster, Germany.
According to the Global-Burden-of-diseases study, chronic pruritus (CP) can be considered as one of the fifty central and most stressful diseases worldwide. (1) CP causes an unpleasant need to scratch and dramatically impacts patients' quality of life. (2,3) Its origin can be dermatologic and non-dermatologic. Read More
Br J Dermatol 2018 Oct 19. Epub 2018 Oct 19.
Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology and, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Background: Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever and monoclonal gammopathy, which manifest mostly in the second half of life. It involves overactivation of the interleukin (IL)-1 system, but the exact pathophysiological pathways remain largely unknown.
Objectives: To identify and characterize the pathogenetic players in SchS. Read More
J Hematol Oncol 2018 Oct 11;11(1):124. Epub 2018 Oct 11.
Pharmacogenomic Unit, Department of Genetics, Curie Institute, PSL Research University, Paris, France.
Background: Postmenopausal women with large, hormone receptor (HR)-positive/HER2-negative and low-proliferative breast cancer derived a benefit from neoadjuvant endocrine therapy (NET) in the CARMINA02 trial. This study was designed to correlate gene expression and mutation profiles with both response to NET and prognosis.
Methods: Gene expression profiling using RNA sequencing was performed in 86 pre-NET and post-NET tumor samples. Read More
Pediatr Crit Care Med 2018 Dec;19(12):e653-e661
Hospital Universitario Austral, Buenos Aires, Argentina.
Objective: To assess the performance of the Pediatric Index of Mortality 3 score in a population of children admitted to PICUs in Argentina.
Design: Prospective, national, multicenter study.
Setting: Forty-nine PICUs located in Argentina belonging to public and private institutions. Read More
Commun Biol 2018 7;1:63. Epub 2018 Jun 7.
1The Whitney Laboratory for Marine Bioscience, Sea Turtle Hospital, University of Florida, St. Augustine, FL 32080 USA.
Wildlife populations are under intense anthropogenic pressures, with the geographic range of many species shrinking, dramatic reductions in population numbers and undisturbed habitats, and biodiversity loss. It is postulated that we are in the midst of a sixth (Anthropocene) mass extinction event, the first to be induced by human activity. Further, threatening vulnerable species is the increased rate of emerging diseases, another consequence of anthropogenic activities. Read More
Front Hum Neurosci 2018 11;12:343. Epub 2018 Sep 11.
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Reversal learning (RL) has been widely used for assessment of behavioral adaptation, impulsivity, obsession, and compulsion in healthy controls as well as people suffering from psychiatric and neurological disorders such as Parkinson's disease (PD). Nevertheless, studies addressing high cognitive functions such as metacognition in PD are scarce. Here, we address for the first time the effect of levodopa and PD on metacognition within the framework of a RL paradigm. Read More
Brain Stimul 2018 Nov - Dec;11(6):1368-1377. Epub 2018 Sep 11.
Department of Neurology and Neurosurgery, Heinrich-Heine-University, Düsseldorf, Germany.
Introduction: Growing evidence suggests that pallidal deep brain stimulation represents a potential new therapeutic avenue in tardive dystonia/dyskinesia, but controlled and blinded randomized studies (RCT) are missing. The present RCT compares dystonia/dyskinesia severity of pallidal neurostimulation in patients with tardive dystonia using a delayed-start design paradigm.
Methods: Dystonia/dyskinesia severity was assessed via blinded videos following pallidal neurostimulation at 3 (blinded phase) and 6 months (open extension phase). Read More
Curr Opin Lipidol 2018 Dec;29(6):474-480
Department of Experimental Vascular Medicine.
Purpose Of Review: Evidence accumulates suggesting that cellular metabolic alterations fuel and dictate the inflammatory state of cells. In this review, we provide an overview of the observed metabolic reprogramming in endothelial cells and innate immune cells upon interaction with modified lipoproteins, thereby contributing to the progression of atherosclerosis.
Recent Findings: Inflammatory endothelial cells at sites exposed to disturbed flow patterns show increased glycolytic activity. Read More
Ann Dermatol Venereol 2018 Dec 14;145(12):735-740. Epub 2018 Sep 14.
Dermatology Department, Hôpitaux Universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France. Electronic address:
Neutrophilic urticarial dermatosis (NUD) is a rare form of dermatosis. In clinical terms, it consists of a chronic or recurrent eruption comprising slightly elevated, pink to reddish plaques or macules. The elementary lesion lasts 24 to 48hours and resolves without leaving any residual pigmentation. Read More
Eur J Cancer Care (Engl) 2018 Sep 11:e12911. Epub 2018 Sep 11.
Centre for Medical Psychology and Evidence-Based Decision-Making, School of Psychology, The University of Sydney, Sydney, New South Wales, Australia.
This study examined the content covered by radiation therapists (RTs) during education sessions; the frequency and types of questions asked by patients; and the relationship between patient characteristics and the number of questions asked. Fifty-eight education sessions were audio-recorded and transcribed verbatim. A coding scheme was developed to examine the frequency of topics covered. Read More
J Stroke Cerebrovasc Dis 2018 Dec 3;27(12):3443-3450. Epub 2018 Sep 3.
French Public Health Agency, Saint-Maurice, France.
Goal: We studied time trends of admission in neurological rehabilitation units (NRU) among patients hospitalised for stroke from 2010 to 2014 and compared prognostic factors of functional gain, home return and inpatient survival.
Methods: Patients hospitalized for Stroke from 2010 to 2014 were selected from the French national hospital databases. Admission in rehabilitation was searched till 3 months. Read More
BMC Genomics 2018 Sep 3;19(1):649. Epub 2018 Sep 3.
Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Background: Hydractinia symbiolongicarpus, a colonial cnidarian, is a tractable model system for many cnidarian-specific and general biological questions. Until recently, tests of gene function in Hydractinia have relied on laborious forward genetic approaches, randomly integrated transgenes, or transient knockdown of mRNAs.
Results: Here, we report the use of CRISPR/Cas9 genome editing to generate targeted genomic insertions in H. Read More
Hautarzt 2018 Sep;69(9):761-772
Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Anstalt des öffentlichen Rechts des Freistaates Sachsen, Fetscherstr. 74, 01307, Dresden, Deutschland.
Schnitzler syndrome is a very rare acquired systemic disease with many similarities to hereditary autoinflammatory syndromes. The main characteristics are generalized exanthema and a monoclonal gammopathy with IgM. Other clinical features include fever, muscle, bone and/or joint pain, and lymphadenopathy. Read More
Transplantation 2018 Aug 20. Epub 2018 Aug 20.
Department of Pediatrics I, University Children's Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.
Background: BK polyomavirus-associated nephropathy (BKPyVAN) constitutes a serious cause of kidney allograft failure, but large-scale data in pediatric renal transplant recipients and a comprehensive analysis of specific risk factors are lacking.
Methods: We analyzed data of 313 patients in the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) registry, with an observation period of 3.3 years (range, 1 - 5). Read More
Neuroimage Clin 2018 9;20:347-356. Epub 2018 Aug 9.
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Recent studies have proposed a connection between the individual alpha band peak frequency and the temporal resolution of visual perception in healthy human participants. This connection rests on animal studies describing oscillations in the alpha band as a mode of phasic thalamocortical information transfer for low-level visual stimuli, which critically relies on GABAergic interneurons. Here, we investigated the interplay of these parameters by measuring occipital alpha band peak frequency by means of magnetoencephalography, visual temporal resolution by means of behavioral testing, and occipital GABA levels by means of magnetic resonance spectroscopy. Read More
Curr Res Transl Med 2018 Sep 11;66(3):83-86. Epub 2018 Aug 11.
CHU Lille, Département de Médecine Interne et Immunologie Clinique, Lille, France.
Patients with HHV-8-negative/idiopathic multicentric Castleman disease (iMCD) experience systemic inflammatory symptoms and polyclonal lymphoproliferation due to an unknown etiology. Schnitzler's syndrome (SS) is characterized by recurrent urticarial rash, monoclonal IgM gammopathy, and other clinical signs of inflammation. To our knowledge, we report the first case of iMCD associated with SS and the fourth case of anakinra inducing a complete response for an iMCD patient. Read More
Plant Physiol 2018 Sep 3;178(1):468-487. Epub 2018 Aug 3.
Institute of Biochemical Plant Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany
Nitrogen dioxide (NO) forms in plants under stress conditions, but little is known about its physiological functions. Here, we explored the physiological functions of NO in plant cells using short-term fumigation of Arabidopsis () for 1 h with 10 µL L NO Although leaf symptoms were absent, the expression of genes related to pathogen resistance was induced. Fumigated plants developed basal disease resistance, or pattern-triggered immunity, against the necrotrophic fungus and the hemibiotrophic bacterium Functional salicylic acid and jasmonic acid (JA) signaling pathways were both required for the full expression of NO-induced resistance against An early peak of salicylic acid accumulation immediately after NO exposure was followed by a transient accumulation of oxophytodienoic acid. Read More
Ann Dermatol 2018 Aug 28;30(4):483-485. Epub 2018 Jun 28.
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Food Sci Technol 2018 Aug 16;55(8):3035-3045. Epub 2018 May 16.
Food Science and Technology Graduate Program, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, Ponta Grossa, PR 84030-900 Brazil.
The objective of this study was to develop a formulation that can retard staling/retrogradation of cheese breads without compromising their texture and expansion properties. During baking the dough expands and becomes soft, with lower density. Binary mixtures of cassava starch (Native + Oxidized) and with guar gum (Oxidized + Guar Gum) as well as a ternary mixture (Native + Oxidized + Guar Gum) were prepared. Read More
Pediatr Nephrol 2018 Dec 30;33(12):2343-2352. Epub 2018 Jul 30.
Department of Pediatrics I, University Children's Hospital, Im Neuenheimer Feld 430, D-69120, Heidelberg, Germany.
Background: JC polyomavirus (JCPyV)-associated nephropathy (JCPyVAN) is a severe, but rare complication in adult renal transplant (RTx) recipients. Related data in pediatric patients are scarce.
Methods: Based on the CERTAIN Registry, we therefore performed a multi-center, retrospective study on the JCPyV antibody status, prevalence of JCPyV replication, and its associated disease in 139 pediatric RTx recipients (mean age, 8. Read More
Clin Cancer Res 2018 Nov 27;24(22):5767-5771. Epub 2018 Jul 27.
Department of Medical Oncology, Institut Curie, PSL Research University, Paris, Saint Cloud, France.
Chemoradiotherapy (CRT) is the current standard of care for patients diagnosed with locally advanced anal squamous cell carcinoma (ASCC), but some patients develop local and/or distant relapse during follow-up. This study was designed to monitor human papillomavirus (HPV) circulating tumor DNA (ctDNA) levels during CRT in patients with ASCC. We analyzed samples from patients with HPV16- or HPV18-positive locally advanced ASCC. Read More
J Am Coll Cardiol 2018 Jul;72(5):501-514
Molecular Cardiology Research Institute, Surgical and Interventional Research Laboratories, and the CardioVascular Center, Tufts Medical Center, Boston, Massachusetts. Electronic address:
Background: Heart failure after an acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. We recently reported that activation of a transvalvular axial-flow pump in the left ventricle and delaying myocardial reperfusion, known as primary unloading, limits infarct size after AMI. The mechanisms underlying the cardioprotective benefit of primary unloading and whether the acute decrease in infarct size results in a durable reduction in LV scar and improves cardiac function remain unknown. Read More
Transplant Direct 2018 Jul 13;4(7):e364. Epub 2018 Jun 13.
Division of Transplantation, Department of Surgery, Lahey Clinic, Burlington, MA.
Background: Variation in the use of immunosuppression regimens after liver transplant has not been well described.
Methods: Immunosuppression regimens used after liver transplant were identified in a novel database integrating national transplant registry and pharmacy fill records for 24 238 recipients (2006-2014). Bilevel hierarchical models were developed to quantify the effects of transplant program, recipient, and donor characteristics on regimen choice. Read More
Environ Pollut 2018 Nov 18;242(Pt A):905-913. Epub 2018 Jul 18.
Chair of Tree Physiology, Institute of Forest Sciences, Albert-Ludwigs-Universität Freiburg, Georges-Köhler-Allee 53, 79110 Freiburg, Germany; King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia.
Vegetation in the Arabian Peninsula is facing high and steadily rising tropospheric ozone pollution. However, little is known about the impacts of elevated ozone on date palms, one of the most important indigenous economic species. To elucidate the physiological responses of date palm to peak levels of acute ozone exposure, seedlings were fumigated with 200 ppb ozone for 8 h. Read More
Plant Cell Environ 2018 Dec 17;41(12):2791-2805. Epub 2018 Aug 17.
Helmholtz Zentrum München, Institute of Biochemical Plant Pathology, Research Unit Environmental Simulation (EUS), Neuherberg, Germany.
It is well known that plant volatiles influence herbivores in their selection of a host plant; however, less is known about how the nonvolatile metabolome affects herbivore host selection. Metabolic diversity between intraspecific plants can be characterized using non-targeted mass spectrometry that gives us a snapshot overview of all metabolic processes occurring within a plant at a particular time. Here, we show that non-targeted metabolomics can be used to reveal links between intraspecific chemical diversity and ecological processes in tansy (Tanacetum vulgare). Read More
Zhonghua Xue Ye Xue Za Zhi 2018 Jun;39(6):523
China-Japan Friendship Hospital, Beijing 100029, China.
Ann Phys Rehabil Med 2018 Jul 19. Epub 2018 Jul 19.
Haute Autorité de Santé, 93210 La Plaine Saint-Denis, France.
Sci Rep 2018 Jul 19;8(1):10958. Epub 2018 Jul 19.
Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover, Foundation, 25761, Büsum, Schleswig-Holstein, Germany.
Ecological and physiological factors lead to different contamination patterns in individual marine mammals. The objective of the present study was to assess whether variations in contamination profiles are indicative of social structures of young male sperm whales as they might reflect a variation in feeding preferences and/or in utilized feeding grounds. We used a total of 61 variables associated with organic compounds and trace element concentrations measured in muscle, liver, kidney and blubber gained from 24 sperm whales that stranded in the North Sea in January and February 2016. Read More
Clin Neurophysiol 2018 Sep 3;129(9):2056-2057. Epub 2018 Jul 3.
I-LABS MEG Brain Imaging Center, University of Washington, Seattle, WA, USA. Electronic address:
MycoKeys 2018 2(36):1-19. Epub 2018 Jul 2.
Senckenberg Biodiversity and Climate Research Centre (SBiK-F), Frankfurt am Main, Germany.
: Environment and geographic processes affect species' distributions as well as evolutionary processes, such as clade diversification. Estimating the time of origin and diversification of organisms helps us understand how climate fluctuations in the past might have influenced the diversification and present distribution of species. Complementing divergence dating with character evolution could indicate how key innovations have facilitated the diversification of species. Read More
NMR Biomed 2018 Sep 5;31(9):e3947. Epub 2018 Jul 5.
Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany.
Hepatic encephalopathy (HE) is triggered by liver cirrhosis and is associated with an increased ammonia level within the brain tissue. The goal of this study was to investigate effects of ammonia on in vitro amide proton transfer (APT)-weighted chemical exchange saturation transfer (CEST) imaging in order to develop an ammonia-sensitive brain imaging method. APT-weighted CEST imaging was performed on phantom solutions including pure ammonia, bovine serum albumin (BSA), and tissue homogenate samples doped with various ammonia concentrations. Read More
Front Plant Sci 2018 8;9:766. Epub 2018 Jun 8.
Institute of Biochemical Plant Pathology, Helmholtz Zentrum München, Munich, Germany.
The branched-chain amino acid (BCAA) related 2-hydroxy carboxylic acid isoleucic acid (ILA) enhances salicylic acid-mediated pathogen defense in . ILA has been identified in as its glucose conjugate correlated with the activity of the small-molecule glucosyltransferase UGT76B1, which can glucosylate both salicylic acid and ILA . However, endogenous levels of the ILA aglycon have not yet been determined . Read More
J Pathol 2018 Sep 7;246(1):103-114. Epub 2018 Aug 7.
Pharmacogenomic Unit, Genetics Department, Curie Institute, PSL Research University, Paris, France.
To ensure their high proliferation rate, tumor cells have an iron metabolic disorder causing them to have increased iron needs, making them more susceptible to iron deprivation. This vulnerability could be a therapeutic target. In breast cancers, the development of new therapeutic approaches is urgently needed for patients with triple-negative tumors, which frequently relapse after chemotherapy and suffer from a lack of targeted therapies. Read More
J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1162-1170. Epub 2018 Jun 2.
Department of Infectious Diseases and Immunity, Jessa Hospital. BIOMED Research Institute, University of Hasselt, Hasselt, Belgium.
A wide differential diagnosis must be considered in a patient presenting with urticarial plaques. Although acute and chronic urticaria are the commonest diagnoses, other differential diagnoses include polymorphous eruption of pregnancy, mast cell disorders, hypereosinophilic syndrome, urticarial vasculitis, pemphigoid, systemic lupus erythematosus, and autoinflammatory disease. This review will specifically address urticarial vasculitis and autoinflammatory syndromes. Read More
Food Chem 2018 Oct 4;264:435-442. Epub 2018 May 4.
State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, 84030-900 Ponta Grossa, PR, Brazil. Electronic address:
Organic amaranth starch (Amaranthus caudatus) was studied after heat-moisture treatment (HMT) using different moisture contents and different times. The starch extracted by the aqueous method presented low lipid and protein content. After HMT, an increase in the thermal stability was identified. Read More
Clin Transplant 2018 Aug 29;32(8):e13302. Epub 2018 Jun 29.
Saint Louis University, St. Louis, MO, USA.
While guidelines support metformin as a therapeutic option for diabetic patients with mild-to-moderate renal insufficiency, the frequency and outcomes of metformin use in kidney transplant recipients are not well described. We integrated national U.S. Read More
Neuropsychologia 2018 Aug 11;117:46-54. Epub 2018 May 11.
Institute of Experimental Psychology, Heinrich-Heine University Düsseldorf, Germany.
Phasic dopamine (DA) signals conveyed from the substantia nigra to the striatum and the prefrontal cortex crucially affect learning from feedback, with DA bursts facilitating learning from positive feedback and DA dips facilitating learning from negative feedback. Consequently, diminished nigro-striatal dopamine levels as in unmedicated patients suffering from Parkinson's Disease (PD) have been shown to lead to a negative learning bias. Recent studies suggested a diminished striatal contribution to feedback processing when the outcome of an action is temporally delayed. Read More
Magn Reson Med 2018 May 12. Epub 2018 May 12.
Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Purpose: The aim of this study was to investigate potential effects of acute caffeine intake on J-difference-edited MRS measures of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA).
Methods: J-difference-edited Mescher-Garwood PRESS (MEGA-PRESS) and conventional PRESS data were acquired at 3T from voxels in the anterior cingulate and occipital area of the brain in 15 healthy subjects, before and after oral intake of a 200-mg caffeine dose. MEGA-PRESS data were analyzed with the MATLAB-based Gannet tool to estimate GABA+ macromolecule (GABA+) levels, while PRESS data were analyzed with LCModel to estimate levels of glutamate, glutamate+glutamine, N-acetylaspartate, and myo-inositol. Read More
BMC Cardiovasc Disord 2018 May 10;18(1):92. Epub 2018 May 10.
Kardiologie I, Zentrum für Kardiologie, German Center for Cardiac and Vascular Research (DZHK), Standort Rhein-Main, University Hospital Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.
Background: Diabetes is among the strongest predictors of outcome after coronary artery stenting and the incidence of negative outcomes is still high in this specific group. Data of long-term outcomes comparing diabetic patients with non-diabetic patients treated with bioresorbable scaffolds are still incomplete. This work evaluates the long-term outcomes after implantation of a coronary bioresorbable scaffold (BRS) in diabetic patients compared to non-diabetics. Read More
Brain Stimul 2018 Sep - Oct;11(5):1132-1139. Epub 2018 Apr 26.
Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany. Electronic address:
Background: Shorter pulse widths than conventional pulse width settings may lead to reduction of side effects and therefore be a valuable therapeutic option for deep brain stimulation (DBS) in patients with essential tremor (ET).
Objective: To compare the DBS effect of shorter pulse width at 40 μs (DBS-40 μs) to conventional pulse width at 60 μs (DBS-60 μs) on the therapeutic window in ET patients.
Methods: For this prospective, randomized, double-blind, crossover study 9 ET patients with chronic DBS of the ventral intermediate nucleus (VIM)/posterior subthalamic area (PSA) were recruited. Read More
J Neurol 2018 Jul 3;265(7):1573-1579. Epub 2018 May 3.
Department of Neurology, Centre for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.
Background: Recently, therapeutic attempts to control motor choreatic hyperkinesia of Huntington's disease (HD) by means of pallidal deep brain stimulation (Gp-DBS) were successful. With respect to the clinical effects of Gp-DBS in juvenile hypokinetic-rigid HD (jHD; Westphal variant), only one single-case has been reported up to date. Oscillatory patterns of the Gp in jHD are not known. Read More