1,019 results match your criteria Schizophreniform Disorder


Bacterial infections among patients with psychiatric disorders: Relation with hospital stay, age, and psychiatric diagnoses.

PLoS One 2018 4;13(12):e0208458. Epub 2018 Dec 4.

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen (UMG), Göttingen, Lower-Saxony, Germany.

The prevalence of infections is supposed to be higher in older patients and to extend the length of hospital stays. This study aimed, first, to test this supposition within a large psychiatric population which we divided into four clusters of psychiatric ICD-10 diagnoses: F00-F03 (dementias), F10 (substance disorders), F20-29 (schizophrenia, schizophreniform and other non-mood psychotic disorders), F32-F33 (major depressive disorders). Second, despite the increasing evidence for the role of infections in psychiatric disorders, it is, to the best of our knowledge, largely unknown whether the rates of infections with pathogens of the four most frequent germ families differ between psychiatric diseases. Read More

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December 2018
1 Read

Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study.

Br J Psychiatry 2018 Nov 26:1-7. Epub 2018 Nov 26.

Professor,Division of Psychological Medicine and Clinical Neurosciences,Cardiff University and School of Psychology, University of Sussex and School of Psychology,Trinity College,UK.

Background: Studies involving clinically recruited samples show that genetic liability to schizophrenia overlaps with that for several psychiatric disorders including bipolar disorder, major depression and, in a population study, anxiety disorder and negative symptoms in adolescence.AimsWe examined whether, at a population level, association between schizophrenia liability and anxiety disorders continues into adulthood, for specific anxiety disorders and as a group. We explored in an epidemiologically based cohort the nature of adult psychopathology sharing liability to schizophrenia. Read More

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November 2018
7 Reads

Changes in insight over the first 24 months of treatment in schizophrenia spectrum disorders.

Schizophr Res 2018 Oct 29. Epub 2018 Oct 29.

Department of Psychiatry, Stellenbosch University, South Africa.

Background: While insight in schizophrenia improves with treatment, significant impairments often persist. The degree of persistence is not well characterised.

Aims: We assessed patient and clinician-rated changes in insight in acutely ill, minimally treated first-episode schizophrenia spectrum disorder patients over 24 months of standardised treatment with a depot antipsychotic. Read More

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October 2018
2 Reads
3.923 Impact Factor

The Psychopathology of Delusion of Control According to Subjective Experience.

Rev Colomb Psiquiatr 2018 Oct - Dec;47(4):221-228. Epub 2017 Apr 1.

York University, Toronto, Canadá.

Background: Delusion of control, including thought insertion, occurs in 20% of patients with schizophrenia. However little is known of its psychopathology, and studies involving patients are scarce.

Aims: To explore the subjective experience of patients with delusion of control and to propose a psychopathological explanation based on empirical evidence. Read More

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April 2017
1 Read

Contribution of stress and coping strategies to problematic Internet use in patients with schizophrenia spectrum disorders.

Compr Psychiatry 2018 Nov 26;87:89-94. Epub 2018 Sep 26.

Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea; Gwangju Bukgu Community Mental Health Center, Gwangju, Republic of Korea; Gwang-ju Mental Health Commission, Gwangju, Republic of Korea. Electronic address:

Introduction: Internet use is already high and increasing rapidly among people with psychotic disorders, but there have been few studies on problematic Internet use (PIU) among patients with schizophrenia spectrum disorders. This study aimed to measure the prevalence of PIU and identify the factors associated with PIU among patients with schizophrenia spectrum disorders.

Methods: A cross-sectional survey was performed that included 368 outpatients with schizophrenia spectrum disorders: 317 with schizophrenia, 22 with schizoaffective disorder, 9 with schizophreniform disorder, and 20 with other schizophrenia spectrum and psychotic disorders. Read More

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November 2018
5 Reads

Recorded atypical hallucinations in psychotic and affective disorders and associations with non-benzodiazepine hypnotic use: the South London and Maudsley Case Register.

BMJ Open 2018 Sep 28;8(9):e025216. Epub 2018 Sep 28.

Department of Psychological Medicine, King's College London, London, UK.

Objectives: Hallucinations are present in many conditions, notably psychosis. Although under-researched, atypical hallucinations, such as tactile, olfactory and gustatory (TOGHs), may arise secondary to hypnotic drug use, particularly non-benzodiazepine hypnotics ('Z drugs'). This retrospective case-control study investigated the frequency of TOGHs and their associations with prior Z drug use in a large mental healthcare database. Read More

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September 2018
1 Read

Cognitive-perceptual deficits and symptom correlates in first-episode schizophrenia.

S Afr J Psychiatr 2017 31;23:1049. Epub 2017 Aug 31.

Department of Statistics and Actuarial Sciences, Stellenbosch University, South Africa.

Background: Thought disorder and visual-perceptual deficits have been well documented, but their relationships with clinical symptoms and cognitive function remain unclear. Cognitive-perceptual deficits may underscore clinical symptoms in schizophrenia patients.

Aim: This study aimed to explore how thought disorder and form perception are related with clinical symptoms and cognitive dysfunction in first-episode schizophrenia. Read More

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August 2017
2 Reads

A causality dilemma: ARFID, malnutrition, psychosis, and hypomagnesemia.

Int J Eat Disord 2018 Sep 7;51(9):1113-1116. Epub 2018 Sep 7.

Eating Recovery Center, Denver, Colorado.

We present a novel case of a woman with coincident occurrence of auditory and visual hallucinations, electrolyte disturbances, chloride unresponsive alkalosis, and an eating disorder. The patient was ultimately diagnosed with Gitelman syndrome comorbid with schizophreniform disorder and avoidant restrictive food intake disorder. Eating disorders are often associated with electrolyte abnormalities which, in turn, can cause or contribute to other neuropsychiatric symptoms. Read More

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September 2018
3 Reads

Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study.

Lancet Psychiatry 2018 Oct 13;5(10):797-807. Epub 2018 Aug 13.

Department of Psychiatry, Brain Center Rudolf Magnus, Utrecht, Netherlands; Department of Neuroscience, University Medical Center, Groningen, Netherlands.

Background: No established treatment algorithm exists for patients with schizophrenia. Whether switching antipsychotics or early use of clozapine improves outcome in (first-episode) schizophrenia is unknown.

Methods: This three-phase study was done in 27 centres, consisting of general hospitals and psychiatric specialty clinics, in 14 European countries and Israel. Read More

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October 2018
3 Reads

Screening for cognitive deficits with the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale.

Clin Rehabil 2018 Jul 17:269215518787324. Epub 2018 Jul 17.

11 Fondation FondaMental, Créteil, France.

Objective:: This study aimed to evaluate the validity of the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale (ECPDS) to discriminate for cognitive impairment in schizophrenia.

Design:: This multicentre cross-sectional study used a validation design with receiver operating characteristic (ROC) curve analysis.

Settings:: The study was undertaken in a French network of seven outward referral centres. Read More

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July 2018
4 Reads

Early interventions in a US military FIRST episode psychosis program.

Early Interv Psychiatry 2018 12 3;12(6):1243-1249. Epub 2018 Jul 3.

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.

Aim: Naval Medical Center San Diego's Psychiatric Transition Program is a specialized first episode psychosis treatment program that delivers coordinated specialty care to military service members with psychotic disorders. Due to the unique military environment, military service members with first episode psychosis are hypothesized to receive care very early after the emergence of first psychotic symptoms, resulting in significantly reduced duration of untreated psychosis. This study's aim is to calculate the duration of untreated psychosis for patients enrolled in Naval Medical Center San Diego's Psychiatric Transition Program (NMCSD PTP) from 01JUL2014-31DEC2016. Read More

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December 2018
5 Reads

Serotonin Syndrome in Obstetrics: A Case Report and Review of Management.

Mil Med 2018 Jun 13. Epub 2018 Jun 13.

Department of Obstetrics and Gynecology, 36000 Darnall Loop, Fort Hood, TX.

Serotonin syndrome (SS) is a life-threatening condition, usually precipitated by a combination of serotonergic agents. Data regarding the incidence and management of SS in obstetrics are limited. This study presents a case of SS provoked by an atypical antipsychotic in a second trimester, singleton gestation, and reviews the management of SS in an obstetric patient. Read More

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June 2018
10 Reads

Myoclonic Jerks and Schizophreniform Syndrome: Case Report and Literature Review.

Front Psychiatry 2018 1;9:161. Epub 2018 May 1.

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Schizophreniform syndromes can be divided into primary idiopathic forms as well as different secondary organic subgroups (e.g., paraepileptic, epileptic, immunological, or degenerative). Read More

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May 2018
4 Reads

Size and clustering of ethnic groups and rates of psychiatric admission in England.

BJPsych Bull 2018 Aug 11;42(4):141-145. Epub 2018 May 11.

Newcastle University,Newcastle.

Aims and methodTo compare rates of admission for different types of severe mental illness between ethnic groups, and to test the hypothesis that larger and more clustered ethnic groups will have lower admission rates. This was a descriptive study of routinely collected data from the National Health Service in England.

Results: There was an eightfold difference in admission rates between ethnic groups for schizophreniform and mania admissions, and a fivefold variation in depression admissions. Read More

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August 2018
1 Read

Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders.

Eur Arch Psychiatry Clin Neurosci 2018 May 2. Epub 2018 May 2.

K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, NORMENT, University of Oslo, Oslo, Norway.

Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. We here examined the association between lipid levels and depressive symptomatology in patients with psychotic disorders, in addition to their possible inflammatory associations. Participants (n = 652) with the following distribution: schizophrenia, schizophreniform and schizoaffective disorder (schizophrenia group, n = 344); bipolar I, II, NOS, and psychosis NOS (non-schizophrenia group, n = 308) were recruited consecutively from the Norwegian Thematically Organized Psychosis (TOP) Study. Read More

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May 2018
17 Reads

Effects of cannabis use on body mass, fasting glucose and lipids during the first 12 months of treatment in schizophrenia spectrum disorders.

Schizophr Res 2018 Sep 6;199:90-95. Epub 2018 Mar 6.

Department of Psychiatry, Stellenbosch University, South Africa.

While acute cannabis use stimulates appetite, general population studies suggest that chronic use is associated with reduced risk of obesity and other cardiometabolic risk factors. In this study we investigated changes in body mass index (BMI), fasting blood glucose and lipids, and rates of metabolic syndrome risk factors in cannabis users vs. non-users in 109 minimally treated patients with first-episode schizophrenia, schizophreniform or schizo-affective disorder who were treated according to a standardized treatment regime with depot antipsychotic medication over 12 months. Read More

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September 2018
3 Reads

Autopsy-proven Mirtazapine Withdrawal-induced Mania/Hypomania Associated with Sudden Death.

J Pharmacol Pharmacother 2017 Oct-Dec;8(4):185-187

San Joaquin County Coroner, CA, USA.

Manic episodes induced by antidepressant withdrawal are rarely reported. Mirtazapine is a tetracyclic, piperazinoazepine compound and is a noradrenergic, adrenergic, serotonergic, histaminergic, and muscarinic-antagonist antidepressant that is used for the treatment of major depression and other psychiatric illnesses. There are several reported cases of manic/hypomanic episodes induced by mirtazapine withdrawal based on suspected clinical symptoms that were not confirmed by autopsy and toxicology. Read More

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February 2018
4 Reads

Detection of early psychotic symptoms: Validation of the Spanish version of the "Symptom Onset in Schizophrenia (SOS) inventory".

Psychiatry Res 2018 03 14;261:68-72. Epub 2017 Dec 14.

Barcelona Clinic Schizophrenia Unit (BCSU), Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Biomedical Research Networking Centre in Mental Health (CIBERSAM), The August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Catalonia, Spain. Electronic address:

The period of subclinical signs that precedes the onset of psychosis is referred to as the prodrome or high-risk mental state. The "Symptom Onset in Schizophrenia (SOS) inventory" is an instrument to characterize and date the initial symptoms of a psychotic illness. The present study aims to provide reliability and validity data for clinical and research use of the Spanish version of the SOS. Read More

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March 2018
20 Reads

Systematic review and meta-analysis found higher levels of behavioural problems in male left-behind children aged 6-11 years.

Acta Paediatr 2018 Aug 18;107(8):1327-1334. Epub 2018 Jan 18.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Aim: Left-behind children (LBC) now account for more than 1 in 5 Chinese children, and they often suffer from behavioural problems when their parents leave their rural homes to seek work in urban areas. The primary aim of this meta-analysis was to compare the incidence rates and factor scores of behavioural problems in LBC, who now account for more than one-fifth of Chinese children, and non-LBC.

Methods: This systematic review and meta-analysis explored the children's characteristic behavioural problems using the Achenbach Child Behaviour Check List. Read More

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August 2018
12 Reads

Childhood adversity and cognitive function in schizophrenia spectrum disorders and healthy controls: evidence for an association between neglect and social cognition.

Psychol Med 2018 Oct 22;48(13):2186-2193. Epub 2017 Dec 22.

Department of Psychiatry,Stellenbosch University,Cape Town,South Africa.

Background: Childhood adversity is associated with cognitive impairments in schizophrenia. However, findings to date are inconsistent and little is known about the relationship between social cognition and childhood trauma. We investigated the relationship between childhood abuse and neglect and cognitive function in patients with a first-episode of schizophrenia or schizophreniform disorder (n = 56) and matched healthy controls (n = 52). Read More

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October 2018
1 Read

Do patients with schizophreniform and bipolar disorders show an intrathecal, polyspecific, antiviral immune response? A pilot study.

Fluids Barriers CNS 2017 Dec 7;14(1):34. Epub 2017 Dec 7.

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: We previously described inflammatory cerebrospinal fluid (CSF) alterations in a subgroup of patients with schizophreniform disorders and the synthesis of polyspecific intrathecal antibodies against different neurotropic infectious pathogens in some patients with bipolar disorders. Consequently, we have measured the prevalence of a positive MRZ reaction (MRZR)-a marker for a polyspecific, antiviral, intrathecal, humoral immune response composed of three antibody indices for the neurotropic viruses of measles (M), rubella (R), and varicella zoster (Z)-in these patients.

Methods: We analyzed paired CSF and serum samples of 39 schizophreniform and 39 bipolar patients. Read More

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December 2017
11 Reads

Motor dysfunction as an intermediate phenotype across schizophrenia and other psychotic disorders: Progress and perspectives.

Schizophr Res 2018 Oct 1;200:26-34. Epub 2017 Nov 1.

Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany.

Primary motor abnormalities (PMA), as found in patients with schizophrenia, are quantitatively and qualitatively distinct markers of motor system abnormalities. PMA have been often referred to phenomena that are present across schizophrenia-spectrum disorders. A dysfunction of frontoparietal and subcortical networks has been proposed as core pathophysiological mechanism underlying the expression of PMA. Read More

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October 2018
1 Read

Different communication strategies for disclosing a diagnosis of schizophrenia and related disorders.

Cochrane Database Syst Rev 2017 10 24;10:CD011707. Epub 2017 Oct 24.

Research Institute for Primary Care and Health Sciences, Keele University, Staffordshire, UK, ST5 5BG.

Background: Delivering the diagnosis of a serious illness is an important skill in most fields of medicine, including mental health. Research has found that communication skills can impact on a person's recall and understanding of the diagnosis, treatment options and prognosis. People may feel confused and perplexed when information about their illness is not communicated properly. Read More

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October 2017
1 Read

Prospective Relationships Between Motivation and Functioning in Recovery After a First Episode of Schizophrenia.

Schizophr Bull 2018 02;44(2):369-377

Department of Occupational Therapy, Boston University.

Diminished motivation is associated with robust impairment in psychosocial functioning in schizophrenia (SZ). Little is known about the reciprocal relationships between motivation and functioning, particularly following a first episode of psychosis. We tested bidirectional associations between motivation and social and occupational functioning in the year following a first episode of SZ spectrum disorder among patients in the Recovery After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study. Read More

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February 2018
13 Reads

Baseline Demographics and Characteristics From a Paliperidone Palmitate Study in Subjects with Recent-Onset Schizophrenia or Schizophreniform Disorder.

Psychopharmacol Bull 2017 Aug;47(3):8-16

Drs. Brown, Alphs, Yue, Janssen Scientific Affairs, LLC, Titusville, NJ; Dr. Turkoz, Janssen Research & Development, LLC, Titusville, NJ.

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August 2017
11 Reads

Graves' Thyrotoxicosis Presenting as Schizophreniform Psychosis: A Case Report and Literature Review.

Int J Endocrinol Metab 2017 Jan 25;15(1):e41977. Epub 2016 Dec 25.

Department of Psychiatry, Enugu State University of Science and Technology, Enugu, Nigeria.

Psychosis, as the first presentation of thyrotoxicosis, is extremely rare. Consequently, it is often misdiagnosed as a primary psychiatric disorder, especially in developing countries with poor healthcare facilities. Owing to the high level of illiteracy and lack of knowledge, it is fairly common to ascribe many illnesses to spiritual attacks in Nigeria and other African countries, especially when the disease is rarely seen or is associated with psychiatric manifestations. Read More

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January 2017
2 Reads

Gesture impairments in schizophrenia are linked to increased movement and prolonged motor planning and execution.

Schizophr Res 2018 Oct 11;200:42-49. Epub 2017 Jul 11.

Translational Research Center, University Hospital of Psychiatry, University of Bern, Switzerland. Electronic address:

Schizophrenia patients present with a variety of impaired nonverbal communication skills. Performance of hand gestures is frequently impaired and associated with ratings of motor abnormalities. However, the impact of motor abnormalities to gesture performance remains unclear. Read More

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October 2018
9 Reads
2 Citations
3.920 Impact Factor

Ventricular volumes across stages of schizophrenia and other psychoses.

Aust N Z J Psychiatry 2017 Oct 1;51(10):1041-1051. Epub 2017 Jul 1.

4 Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Parkville, VIC, Australia.

Objective: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis.

Methods: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1. Read More

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October 2017
12 Reads

Substance abuse and gender differences in first episode psychosis: Impact on hospital readmissions.

Rev Psiquiatr Salud Ment 2018 Jan - Mar;11(1):27-35. Epub 2017 Jun 23.

Salut Mental, Corporació Sanitària Parc Taulí, Sabadell, Barcelona, España; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, España.

Introduction: There have been controversial results in the study of gender differences in first episode psychosis (FEP). Substance abuse is the main existing comorbidity in FEP, and has been associated with worse prognosis and greater symptom severity.

Objectives: To explore gender differences in FEP in relation to drug abuse, and their relationship with hospital readmissions. Read More

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December 2018
13 Reads

Mood Symptoms in Stabilized Patients with Schizophrenia: A Bipolar Type with Predominant Psychotic Features?

Psychiatr Danub 2017 Jun;29(2):148-154

3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Greece.

Background: Schizophrenia (SZ) and bipolar disorder (BD) are traditionally distinguished on the basis of progressive deterioration and long-term outcome, but a more dimensional approach is warranted. There are limited data on the occurrence of manic symptoms in patients with schizophrenia. The aim of the current study was to search for patterns in the clinical symptomatology, which may suggest the presence of one or several mood disorders under the label of schizophrenia. Read More

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June 2017
15 Reads

Peripheral blood gene expression of acute phase proteins in people with first episode psychosis.

Brain Behav Immun 2017 Oct 13;65:337-341. Epub 2017 Jun 13.

Research Division, Institute of Mental Health, Singapore; Department of General Psychiatry 1, Institute of Mental Health, Singapore.

Background: There is a growing interest in the association between schizophrenia and the activation of inflammatory system with signs of acute phase (AP) response. Majority of such studies had focused on C-reactive protein (CRP). The aims of the present study were (i) to examine the gene expression profiles of other acute phase proteins (APP), namely haptoglobin (HP), alpha-1 antitrypsin (A1T), and alpha-2 macroglobulin (A2M) in patients with first episode psychosis (FEP) over a period of three months and (ii) to explore the association between APP levels and severity of symptoms. Read More

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October 2017
15 Reads

Clozapine dose for schizophrenia.

Cochrane Database Syst Rev 2017 Jun 14;6:CD009555. Epub 2017 Jun 14.

Department of Psychiatry, Morecambe Community Mental Health Team, Victoria House, Thornton RD, Morecambe, UK, LA4 5NN.

Background: Schizophrenia and related disorders such as schizophreniform and schizoaffective disorder are serious mental illnesses characterised by profound disruptions in thinking and speech, emotional processes, behaviour and sense of self. Clozapine is useful in the treatment of schizophrenia and related disorders, particularly when other antipsychotic medications have failed. It improves positive symptoms (such as delusions and hallucinations) and negative symptoms (such as withdrawal and poverty of speech). Read More

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June 2017
7 Reads

Differentiation Between Schizophreniform Configurations and Psychotic Personality Structures.

Authors:
Julie Dauphin

Psychodyn Psychiatry 2017 ;45(2):187-215

Institut universitaire en santé mentale de Montréal (Programme des troubles psychotiques), Montréal (Québec), Canada.

The symptom overlap between primary psychotic and severe personality disorders renders timely diagnosis challenging, which often results in ambiguous treatment and poorly defined outcomes. Kernberg's (1984) structural model of personality, treating symptoms as a non-pathognomonic higher order construct, has much contributed to our understanding of the nature of some severe disorders, highlighting fundamental facets of personality function. However, the model's main focus is on borderline personality organization and thus offers an incomplete formulation of psychotic structure. Read More

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March 2018
15 Reads

Ayahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies.

Ther Adv Psychopharmacol 2017 Apr 23;7(4):141-157. Epub 2017 Feb 23.

Department of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil; National Institute for Translational Medicine (INCT-TM), CNPq, Ribeirão Preto, Brazil.

Ayahuasca is a hallucinogen brew traditionally used for ritual and therapeutic purposes in Northwestern Amazon. It is rich in the tryptamine hallucinogens dimethyltryptamine (DMT), which acts as a serotonin 5-HT agonist. This mechanism of action is similar to other compounds such as lysergic acid diethylamide (LSD) and psilocybin. Read More

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April 2017
21 Reads

Steroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies.

Front Psychiatry 2017 21;8:64. Epub 2017 Apr 21.

Faculty of Medicine, Department of Psychiatry, Section for Experimental Neuropsychiatry, University of Freiburg, Freiburg, Germany.

Background: Schizophreniform syndromes can be divided into primary forms from polygenic causes or secondary forms due to immunological, epileptiform, monogenic, or degenerative causes. Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a secondary immunological form associated with increased thyroid antibodies, such as antithyroid peroxidase antibodies and shows a good response to corticosteroids.

Case Presentation: We present the case of a 41-year-old woman suffering from a schizophreniform syndrome. Read More

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April 2017
18 Reads

Intrathecal Thyroid Autoantibody Synthesis in a Subgroup of Patients With Schizophreniform Syndromes.

J Neuropsychiatry Clin Neurosci 2017 28;29(4):365-374. Epub 2017 Apr 28.

From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).

Schizophreniform syndromes in combination with autoimmune thyroiditis and increased serum thyroid antibodies lead healthcare practitioners to consider a diagnosis of Hashimoto's encephalopathy. To detect specific biomarkers, the authors analyzed whether intrathecal antithyroid antibody synthesis occurred in a subgroup of schizophreniform patients. In doing so, the authors analyzed thyroid antibodies in paired cerebrospinal fluid and serum samples from 100 schizophreniform patients. Read More

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May 2018
9 Reads

Brain volume changes over the first year of treatment in schizophrenia: relationships to antipsychotic treatment.

Psychol Med 2017 Sep 28;47(12):2187-2196. Epub 2017 Mar 28.

Department of Psychiatry, Faculty of Medicine and Health Sciences,Stellenbosch University,Cape Town,South Africa.

Background: Progressive brain volume reductions have been described in schizophrenia, and an association with antipsychotic exposure has been reported.

Methods: We compared percentage changes in grey and white matter volume from baseline to month 12 in 23 previously antipsychotic-naïve patients with a first episode of schizophrenia or schizophreniform disorder who were treated with the lowest effective dose of flupenthixol decanoate depot formulation, with 53 matched healthy individuals. Total antipsychotic dose was precisely calculated and its relationship with brain volume changes investigated. Read More

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September 2017
1 Read

Red Flags: Clinical Signs for Identifying Autoimmune Encephalitis in Psychiatric Patients.

Front Psychiatry 2017 16;8:25. Epub 2017 Feb 16.

Autoimmune Encephalopathies Group, German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany; Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Autoimmune mechanisms causing diverse psychiatric symptoms are increasingly recognized and brought about a paradigm shift in neuropsychiatry. Identification of underlying antibodies against neuronal ion channels or receptors led to the speculation that a number of patients go misdiagnosed with a primary psychiatric disease. However, there is no clear consensus which clinical signs in psychiatric patients should prompt further investigations including measurement of anti-neuronal autoantibodies. Read More

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February 2017
2 Reads

Neurological soft signs in first-episode schizophrenia: State- and trait-related relationships to psychopathology, cognition and antipsychotic medication effects.

Schizophr Res 2017 10 24;188:144-150. Epub 2017 Jan 24.

Psychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Background: Neurological soft signs (NSS) are proposed to represent both state- and trait-related features of schizophrenia.

Method: We assessed the course of NSS with the Neurological Evaluation Scale (NES) over 12months of standardised treatment in 126 patients with first-episode schizophrenia, schizophreniform or schizoaffective disorder, and evaluated their state- and trait-related associations with psychopathology, functionality, cognition and antipsychotic treatment. We considered change scores from baseline to be state-related and endpoint scores to be trait-related. Read More

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October 2017
36 Reads

Quantification of cell-free DNA in blood plasma and DNA damage degree in lymphocytes to evaluate dysregulation of apoptosis in schizophrenia patients.

J Psychiatr Res 2017 04 8;87:15-22. Epub 2016 Dec 8.

Research Centre for Medical Genetics (RCMG), Moscow, 115478, Russia; V. A. Negovsky Research Institute of General Reanimatology, Moscow, 107031, Russia.

Oxidative DNA damage has been proposed as one of the causes of schizophrenia (SZ), and post mortem data indicate a dysregulation of apoptosis in SZ patients. To evaluate apoptosis in vivo we quantified the concentration of plasma cell-free DNA (cfDNA index, determined using fluorescence), the levels of 8-oxodG in cfDNA (immunoassay) and lymphocytes (FL1-8-oxodG index, flow cytometry) of male patients with acute psychotic disorders: paranoid SZ (total N = 58), schizophreniform (N = 11) and alcohol-induced (N = 14) psychotic disorder, and 30 healthy males. CfDNA in SZ (N = 58) does not change compared with controls. Read More

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April 2017
7 Reads

Hypocalcemia Masquerading as Schizophreniform Disorder.

Indian J Psychol Med 2016 Sep-Oct;38(5):463-465

Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Among the symptoms of hypocalcemia, tetany, papilledema, and seizures may occur in patients who develop hypocalcemia acutely. We describe a rare case of hypocalcemia presenting as schizophreniform disorder. Among other presentations of hypocalcemia, one should also look for the relation between psychotic symptoms and calcium levels in a patient presenting with psychotic symptoms. Read More

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November 2016
2 Reads

Nitric Oxide's Involvement in the Spectrum of Psychotic Disorders.

Curr Med Chem 2016 ;23(24):2680-2691

Hospital das Clínicas, Av. Bandeirantes, 3900, 36o, CEP 14048-900, Monte Alegre, Ribeirão Preto, SP, Brazil.

Background: Recent findings suggest that dopaminergic abnormalities found in psychotic disorders may be secondary to nitric oxide dysfunctions. Nitric oxide seems to influence glutamatergic and dopaminergic neurotransmission, both of which have been associated with psychosis.

Objective: To search and review published works which examined the influence of nitric oxide in psychotic disorders subjects. Read More

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February 2017
4 Reads

Vitamin D Deficiency in Adult Patients with Schizophreniform and Autism Spectrum Syndromes: A One-Year Cohort Study at a German Tertiary Care Hospital.

Front Psychiatry 2016 6;7:168. Epub 2016 Oct 6.

Section of Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg , Freiburg , Germany.

Introduction: Vitamin D has many immunomodulatory, anti-inflammatory, and neuroprotective functions, and previous studies have demonstrated an association between vitamin D deficiency and neuropsychiatric disease. The aim of our study was to analyze the prevalence of vitamin D deficiency in a 1-year cohort of adult inpatients with schizophreniform and autism spectrum syndromes in a naturalistic inpatient setting in Germany.

Participants And Methods: Our study was comprised of 60 adult schizophreniform and 23 adult high-functioning autism spectrum patients who were hospitalized between January and December of 2015. Read More

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October 2016
7 Reads

Sex Differences in Severity, Social Functioning, Adherence to Treatment, and Cognition of Adolescents with Schizophrenia.

Schizophr Res Treatment 2016 14;2016:1928747. Epub 2016 Sep 14.

Hospital Psiquiátrico Infantil, Mexico City, Mexico.

Previous studies have reported sex differences in the clinical presentation and outcome of adult patients with schizophrenia; the aim of present study was to compare the clinical characteristics, social functioning, adherence to treatment, and cognition of adolescents with this diagnosis in a six-month followup. A total of 87 adolescents with a DSM-IV diagnosis of schizophrenia or schizophreniform disorder were evaluated with the Positive and Negative Symptoms Scale (PANSS), the Matrics Consensus Cognitive Battery (MCCB), Personal and Social Performance Scale (PSP), and the Rating of Medication Influences (ROMI). Both groups showed a similar improvement in all PANSS factors and in the PSP scores during the followup. Read More

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September 2016
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Psychosis of epilepsy: a multifaceted neuropsychiatric disorder.

CNS Spectr 2016 Jun;21(3):247-57

2Institute of Cognitive Neuroscience,University College,London,UK.

Psychosis of epilepsy (POE) is a term applied to a group of psychotic disorders with a distinct phenomenology in which potential etiopathogenic mechanisms are believed to be closely related to a seizure disorder. POE can present as interictal psychotic episodes, which may often differ semiologically from primary schizophrenic disorder. They may present as ictal or postictal psychotic episodes and may be the expression of an iatrogenic process to pharmacologic and/or surgical interventions. Read More

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June 2016
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Seropositivity of neurotropic infectious agents in first-episode schizophrenia patients and the relationship with positive and negative symptoms.

Psychiatr Danub 2016 Jun;28(2):132-8

Department of Psychiatry, Gulhane Military Medical School, Ankara, Turkey,

Background: According to the neurodevelopmental model, schizophrenia is a disorder that occurs as a result of different etiologic factors during brain development, including viral infections. However, it is unclear whether these infections are related to the disease or whether they affect the symptom pattern. We investigated the presence of four herpes viruses (EBV, CMV, HSV-1 and HSV-2) in first-episode schizophrenia patients and compared seropositive with seronegative patients and healthy volunteers to reveal the etiological role of viral agents on schizophrenia symptoms. Read More

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June 2016
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[Psychogenic depression and endogenous process (to the problem of reactive schizophrenia)].

Zh Nevrol Psikhiatr Im S S Korsakova 2016 ;116(5):4-12

Mental Health Research Center, Moscow, Russia; Sechenov First Moscow State Medical University, Moscow, Russia.

Objective: To conduct clinical differentiation of stress-induced conditions in schizophrenia and schizophrenia spectrum disorders according to the concept of so-called "Reactive schizophrenia" (J. Berze).

Material And Methods: A sample consisted of 40 patients (14 male, 26 female, mean age 38. Read More

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August 2018
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The McLean-Harvard First-Episode Project: Early Course in 114 Cases of First-Episode Nonaffective Psychoses.

J Clin Psychiatry 2016 06;77(6):781-8

International Consortium for Bipolar & Psychotic Disorders Research, McLean Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: Early course in contemporary, clinically treated, nonaffective psychotic disorders other than schizophrenia remains incompletely defined.

Methods: We prospectively, repeatedly, and systematically assessed 114 patients hospitalized for a first episode of DSM-IV-TR nonaffective psychotic illness for ≥ 2 years (1989-1996) using structured (Structured Clinical Interview for DSM-III-R, Patient Edition; Clinical Global Impressions scale; Scale for the Assessment of Negative Symptoms; Scale for the Assessment of Positive Symptoms; and the expanded version of the Brief Psychiatric Rating Scale) and unstructured (best-estimate procedure, life charting) naturalistic follow-up procedures and survival analysis.

Results: Duration of untreated psychosis (22 ± 38 months) was longest with schizophrenia. Read More

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June 2016
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