71,514 results match your criteria Schizophreniform Disorder


Yield of array-CGH analysis in Tunisian children with autism spectrum disorder.

Mol Genet Genomic Med 2022 Jun 27:e1939. Epub 2022 Jun 27.

Child & Adolescent Neuropsychiatry Program, Modena University Hospital & Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with strong genetic underpinnings. Microarray-based comparative genomic hybridization (aCGH) technology has been proposed as a first-level test in the genetic diagnosis of ASD and of neurodevelopmental disorders in general.

Methods: We performed aCGH on 98 Tunisian children (83 boys and 15 girls) diagnosed with ASD according to DSM-IV criteria. Read More

View Article and Full-Text PDF

Association Between Telemedicine Use in Nonmetropolitan Counties and Quality of Care Received by Medicare Beneficiaries With Serious Mental Illness.

JAMA Netw Open 2022 Jun 1;5(6):e2218730. Epub 2022 Jun 1.

Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts.

Importance: Access to specialty mental health care remains challenging for people with serious mental illnesses, such as schizophrenia and bipolar disorder. Whether expansion of telemedicine is associated with improved access and quality of care for these patients is unclear.

Objective: To assess whether greater telemedicine use in a nonmetropolitan county is associated with quality measures, including use of specialty mental health care and medication adherence. Read More

View Article and Full-Text PDF

Prevalence of developmental dyslexia in primary school children: a protocol for systematic review and meta-analysis.

World J Pediatr 2022 Jun 27. Epub 2022 Jun 27.

Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, 55 Zhongshan Avenue West, Tianhe District, Guangzhou, 510631, China.

Background: Developmental dyslexia (DD) is a specific impairment during the acquisition of reading skills and may have a lifelong negative impact on individuals. Reliable estimates of the prevalence of DD serve as the basis for evidence-based health resource allocation and policy making. However, the prevalence of DD in primary school children varies largely across studies. Read More

View Article and Full-Text PDF

Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.

Am J Psychiatry 2022 Jun 27:appiajp21101083. Epub 2022 Jun 27.

Karuna Therapeutics, Boston.

Schizophrenia remains a challenging disease to treat effectively with current antipsychotic medications due to their limited efficacy across the entire spectrum of core symptoms as well as their often burdensome side-effect profiles and poor tolerability. An unmet need remains for novel, mechanistically unique, and better tolerated therapeutic agents for treating schizophrenia, especially those that treat not only positive symptoms but also the negative and cognitive symptoms of the disease. Almost 25 years ago, the muscarinic acetylcholine receptor (mAChR) agonist xanomeline was reported to reduce psychotic symptoms and improve cognition in patients with Alzheimer's disease. Read More

View Article and Full-Text PDF

The interplay between psychopathological symptoms: transdiagnostic cross-lagged panel network model.

BJPsych Open 2022 Jun 27;8(4):e116. Epub 2022 Jun 27.

Department of Psychiatry, Amsterdam University Medical Center, University of Amsterdam, The Netherlands.

Background: Recent paradigm shifts suggest that psychopathology manifests through dynamic interactions between individual symptoms.

Aims: To investigate the longitudinal relationships between symptoms in a transdiagnostic sample of patients with psychiatric disorders.

Method: A two-wave, cross-lagged panel network model of 15 nodes representing symptoms of depression, (social) anxiety and attenuated psychotic symptoms was estimated, using baseline and 1-year follow-up data of 222 individuals with psychiatric disorders. Read More

View Article and Full-Text PDF

Cortisol and dehydroepiandrosterone sulfate in patients with schizophrenia spectrum disorders with respect to cognitive performance.

Compr Psychoneuroendocrinol 2021 May 3;6:100041. Epub 2021 Mar 3.

Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.

Prolonged activation of the hypothalamic-pituitary-adrenal (HPA) axis associated with hypercortisolemia may lead to impairments of cognition in various populations. Dehydroepiandrosterone sulfate (DHEA-S) can protect the hippocampus from the detrimental effects of cortisol. However, this phenomenon has not been widely investigated in patients with schizophrenia spectrum disorders (SSD). Read More

View Article and Full-Text PDF

Maple syrup urine disease decompensation misdiagnosed as a psychotic event.

Mol Genet Metab Rep 2022 Sep 18;32:100886. Epub 2022 Jun 18.

Children's National Rare Disease Institute, Washington, DC, United States of America.

Maple syrup urine disease (MSUD) is an autosomal recessive metabolic disease resulting in impaired or absent breakdown of branched-chain amino acids (BCAA) valine, isoleucine, and leucine. Classic MSUD often presents in post-natal periods, at times before newborn screening results, and is treated with a protein restricted diet supplemented with medical food and close follow up to prevent toxic buildup of blood leucine. Acute episodes of decompensation are prevented by early recognition and treatment. Read More

View Article and Full-Text PDF
September 2022

Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome.

Compr Psychoneuroendocrinol 2022 Feb 15;9:100103. Epub 2021 Dec 15.

Clinical Psychology Unit for Intellectual and Developmental Disabilities, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.

Background: 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated to a high risk for psychiatric disorders, including psychosis. Individuals with 22q11DS are thought to experience increased levels of chronic stress, which could lead to alterations in hypothalamic-pituitary-adrenocortical (HPA)-axis functioning. Read More

View Article and Full-Text PDF
February 2022

Relation of hyperparathyroidism and hypercalcemia to bipolar and psychotic disorders.

Proc (Bayl Univ Med Cent) 2022 8;35(4):540-542. Epub 2022 Apr 8.

Department of Psychiatry, Houston Methodist Hospital, Houston, Texas.

Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia and an elevated level of serum parathyroid hormone. PHPT leads to hypercalcemia and presents with renal, skeletal, and neuropsychiatric symptoms. Neuropsychiatric manifestations of PHPT such as psychotic, depressive, and anxiety disorders are rare. Read More

View Article and Full-Text PDF

Risk of Mental Illnesses in Patients With Hypopituitarism: A Nationwide Population-Based Cohort Study.

Psychiatry Investig 2022 Jun 15;19(6):418-426. Epub 2022 Jun 15.

Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan.

Objective: The associations of mental illnesses and hypopituitarism have been reported. But, pituitary disorders are rare. The epidemiological studies have rarely addressed these associations between pituitary disorder and mental illnesses. Read More

View Article and Full-Text PDF

Long-term treatment of antipsychotics and combined therapy with other psychotropic medications inducing weight gain in patients with non-affective psychotic disorder: Evidence from GROUP, a longitudinal study.

Psychiatry Res 2022 Jun 12;314:114680. Epub 2022 Jun 12.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands; Altrecht, General Mental Health Care, Utrecht, the Netherlands.

Introduction: Antipsychotics (APs) can cause weight gain. Little is known about changes in weight when APs are combined with other psychotropics. This study examines the weight change in patients undergoing long-term treatment with APs or with AP combined with other psychotropics. Read More

View Article and Full-Text PDF

Grouping affective psychoses in early intervention: Justification for specific treatment guidelines.

Psychiatry Res 2022 Jun 21;314:114690. Epub 2022 Jun 21.

Service of General Psychiatry, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, Place Chauderon 18, Lausanne 1003, Switzerland; Institute of Psychology, Faculty of Social and Political Sciences, University of Lausanne, Place Chauderon 18, Lausanne 1003, Switzerland.

The concept of affective psychosis regroups psychotic disorders with mood syndrome. Previous studies provided evidence to support a dichotomy between affective and non-affective psychoses although questions remain regarding the utility and validity of such a category to develop clinical guidelines. The aim of this study is to explore similarities and differences within affective psychoses to question whether strategies would apply to all the diagnoses falling under this umbrella term. Read More

View Article and Full-Text PDF

Trajectories of adolescent psychotic-like experiences and early cannabis exposure: Results from a Finnish Birth Cohort Study.

Schizophr Res 2022 Jun 23;246:95-102. Epub 2022 Jun 23.

University of Turku, Faculty of Medicine, Department of Psychiatry, Turku, Finland; Addiction Psychiatry Unit, Department of Psychiatry, Turku University Hospital, Turku, Finland.

Background: Longitudinal studies examining the effect of cannabis exposure (CE) on the prognosis of adolescents with psychotic-like experiences (PLEs) are scarce. We examined trajectories of mental health in adolescents with PLEs and cannabis exposure.

Methods: The Northern Finland Birth Cohort 1986 (n = 6552) with linkage to nationwide register data was used. Read More

View Article and Full-Text PDF

Cortical changes in patients with schizophrenia across two ethnic backgrounds.

Sci Rep 2022 Jun 25;12(1):10810. Epub 2022 Jun 25.

LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany.

While it is known that cultural background influences the healthy brain, less is known about how it affects cortical changes in schizophrenia. Here, we tested whether schizophrenia differentially affected the brain in Japanese and German patients. In a sample of 155 patients with a diagnosis of schizophrenia and 191 healthy controls from Japan and Germany, we acquired 3 T-MRI of the brain. Read More

View Article and Full-Text PDF

Impaired Membrane Lipid Homeostasis in Schizophrenia.

Schizophr Bull 2022 Jun 25. Epub 2022 Jun 25.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.

Background And Hypothesis: Multiple lines of clinical, biochemical, and genetic evidence suggest that disturbances of membrane lipids and their metabolism are probably involved in the etiology of schizophrenia (SCZ). Lipids in the membrane are essential to neural development and brain function, however, their role in SCZ remains largely unexplored.

Study Design: Here we investigated the lipidome of the erythrocyte membrane of 80 patients with SCZ and 40 healthy controls using ultra-performance liquid chromatography-mass spectrometry. Read More

View Article and Full-Text PDF

Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredient.

Biomed Pharmacother 2022 Jun 21;153:113299. Epub 2022 Jun 21.

Poona College of Pharmacy, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth (Deemed to be University), Erandwane, Pune 411038, Maharashtra, India. Electronic address:

Neurodegenerative diseases and various other chronic ailments have gradually transformed into public-health issues. Neurodegenerative disorders are a range of progressive neural abnormalities characterized by cellular dysfunctions, neuronal structure, and function loss. Among many chronic disorders, oxidative stress, inflammation, mitochondrial dysregulation, and cellular alterations in the human body are considered the most prevalent diagnostic symptoms. Read More

View Article and Full-Text PDF

Clinical features of UK Biobank subjects carrying protein-truncating variants in genes implicated in schizophrenia pathogenesis.

Authors:
David Curtis

Psychiatr Genet 2022 Jun 27. Epub 2022 Jun 27.

UCL Genetics Institute, University College London and Centre for Psychiatry, Queen Mary University of London, London, UK.

Objective: The SCHEMA consortium has identified 10 genes in which protein-truncating variants (PTVs) confer a substantial risk of schizophrenia. This study aimed to determine whether carrying these PTVs was associated with neuropsychiatric impairment in the general population.

Methods: Phenotype fields of exome-sequenced participants in the UK Biobank who carried PTVs in these genes were studied to determine to what extent they demonstrated features of schizophrenia or had neuropsychiatric impairment. Read More

View Article and Full-Text PDF

Menstrual cycle changes and mental health states of women hospitalized due to COVID-19.

PLoS One 2022 24;17(6):e0270658. Epub 2022 Jun 24.

Faculty of Medicine University of Indonesia-Cipto Mangunkusumo National Hospital, Division of Reproductive Immunoendocrinology, Department of Obstetrics & Gynecology, Jakarta, Indonesia.

Purpose: Many studies have evaluated the impact of the COVID-19 pandemic on women's mental health and menstrual changes. However, most of these studies only included nonhospitalized COVID-19 patients, while information on hospitalized women is very limited. Thus, this study aimed to examine the mental health status and menstrual changes in hospitalized female COVID-19 patients. Read More

View Article and Full-Text PDF

[Symptom monitoring by patients with a psychiatric disorder in palliative care].

Authors:
H de Kam J Deenik

Tijdschr Psychiatr 2022 ;64(6):359-365

Background: Hardly any research has been conducted into systematic symptom monitoring in palliative care for patients with a psychiatric disorder.
AIM: To gain insight into the usefulness of the Utrecht Symptom Diary (USD) and the symptom burden of patients with a psychiatric disorder in the palliative phase.
METHOD: A pragmatic retrospective study using completed USDs by patients (USD-P) and/or caregivers (USD-Z) at the palliative unit and three clinical departments of geriatric psychiatry of GGz Centraal, from October 2011 to January 2018. Read More

View Article and Full-Text PDF

Atypical antipsychotic drugs in dual disorders: current evidence and clinical guidelines.

Curr Pharm Des 2022 Jun 23. Epub 2022 Jun 23.

Department of Neurosciences, Imaging and Clinical Sciences, Università degli Studi G. D'Annunzio, 66100 Chieti-Pescara, Italy.

Background: Concurrent disorder or dual diagnosis refers to a combination of substance use disorders and mental disorders that occur in the same patient simultaneously. These conditions pose significant clinical and healthcare impacts and are often underdiagnosed, undertreated, and complex to manage.

Objective: We assessed the quality of current pharmacological recommendations for the management of dual diagnosis, particularly by evaluating the use of second-generation antipsychotics (SGA). Read More

View Article and Full-Text PDF

The profile of offenders accused of rape referred to the Observation Ward of the Free State Psychiatric Complex, Bloemfontein, South Africa, 2011-2015.

S Afr J Psychiatr 2022 31;28:1807. Epub 2022 May 31.

Department of Biostatistics, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

Background: Sexual assault in South Africa has reached alarming proportions. Mental illness amongst offenders accused of rape is one of the complicating factors.

Aim: To describe the sociodemographic, clinical and forensic profile of alleged offenders accused of rape referred to a South African tertiary public psychiatric hospital for forensic evaluation, as well as describe the profile of the reported victims. Read More

View Article and Full-Text PDF

Cognitive Behavioral Therapy Program for Cannabis Use Cessation in First-Episode Psychosis Patients: A 1-Year Randomized Controlled Trial.

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain.

Despite the negative influence of cannabis use on the development and prognosis of first-episode psychosis (FEP), there is little evidence on effective specific interventions for cannabis use cessation in FEP. The aim of this study was to compare the efficacy of a specific cognitive behavioral therapy (CBT) for cannabis cessation (CBT-CC) with treatment as usual (TAU) in FEP cannabis users. In this single-blind, 1-year randomized controlled trial, 65 participants were randomly assigned to CBT-CC or TAU. Read More

View Article and Full-Text PDF

Profiles in Criminal Psychopathology: A Multiple Case Report Study of the Factor.

Int J Environ Res Public Health 2022 Jun 7;19(12). Epub 2022 Jun 7.

Department of Sociology, Iowa State University, 510 Farm House Lane, 203A East Hall, Ames, IA 50011, USA.

(1) Background: The one general psychopathology ( Factor) theory asserts that a superordinate dimensional construct encompasses underlying forms of psychopathology, but the theory has limited empirical linkages to criminology. (2) Methods: We utilized case reports from 12 male offenders selected from a federal jurisdiction in the central United States who were in the 99th percentile on a composite indicator of psychopathology to advance a qualitative study of the Factor. (3) Results: Clients experienced frequent and often pathological traumatic experiences and exhibited exceedingly early onset of conduct problems usually during the preschool period. Read More

View Article and Full-Text PDF

Psychosis in Parkinson's Disease: A Lesson from Genetics.

Genes (Basel) 2022 Jun 20;13(6). Epub 2022 Jun 20.

School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.

Psychosis in Parkinson's disease (PDP) represents a common and debilitating condition that complicates Parkinson's disease (PD), mainly in the later stages. The spectrum of psychotic symptoms are heterogeneous, ranging from minor phenomena of mild illusions, passage hallucinations and sense of presence to severe psychosis consisting of visual hallucinations (and rarely, auditory and tactile or gustatory) and paranoid delusions. PDP is associated with increased caregiver stress, poorer quality of life for patients and carers, reduced survival and risk of institutionalization with a significant burden on the healthcare system. Read More

View Article and Full-Text PDF

Exploring the Core Genes of Schizophrenia Based on Bioinformatics Analysis.

Genes (Basel) 2022 May 27;13(6). Epub 2022 May 27.

Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.

Schizophrenia is a clinical syndrome composed of a group of symptoms involving many obstacles such as perception, thinking, emotion, behavior, and the disharmony of mental activities. Schizophrenia is one of the top ten causes of disability globally, accounting for about 1% of the global population. Previous studies have shown that schizophrenia has solid genetic characteristics. Read More

View Article and Full-Text PDF

Relationship of Neuropeptide S with Clinical and Metabolic Parameters of Patients during Rehabilitation Therapy for Schizophrenia.

Brain Sci 2022 Jun 11;12(6). Epub 2022 Jun 11.

Department of Psychiatry, Medical University of Warsaw, 02-091 Warsaw, Poland.

Neuropeptide S (NPS) is a factor associated with the central regulation of body weight, stress, anxiety, learning, memory consolidation, wakefulness-sleep cycle, and anti-inflammatory and neuroplastic effects. Its stress-reducing, anti-anxiety, arousal without anxiety, and pro-cognitive effects represent an interesting option for the treatment of neuropsychiatric disorders. The purpose of the study was to examine the potential associations of NPS levels in the blood with clinical and metabolic parameters during the rehabilitation therapy of patients with schizophrenia. Read More

View Article and Full-Text PDF

Association between Parents' Relationship, Emotion-Regulation Strategies, and Psychotic-like Experiences in Adolescents.

Children (Basel) 2022 May 31;9(6). Epub 2022 May 31.

Division of Medical Humanities & Behavioral Sciences, Tongji University School of Medicine, Shanghai 200331, China.

This study aimed to examine the association between the psychotic-like experiences (PLEs) and emotion-regulation (ER) strategies of adolescents and their parents' relationship, and we hypothesized that the parents' relationship moderates the link between ER strategies and PLEs. We recruited a total of 2708 first-year college students (1659 males and 1049 females) aged 15-20 years (mean = 17.9). Read More

View Article and Full-Text PDF

Enhancing future-directed thinking in people with first-episode psychosis using a guided imagery intervention.

J Behav Ther Exp Psychiatry 2022 Sep 4;76:101738. Epub 2022 Jun 4.

The Oxford Institute of Clinical Psychology Training and Research, Warneford Hospital, Oxford, England, OX3 7JX, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, England, OX3 7JX, UK; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, England, OX3 7JX, UK.

Background And Objectives: Future-directed thinking (FDT) is associated with goal directed behaviour and may differ in people with psychosis compared to non-clinical controls. This study investigated whether guided imagery could enhance positive FDT in people with psychosis.

Method: Participants were 44 people experiencing a first episode of psychosis. Read More

View Article and Full-Text PDF
September 2022

CE: An Evidence-Based Yoga Practice for Hospitalized Adults on Medical-Psychiatric Units.

Am J Nurs 2022 Jul;122(7):28-36

Angela Dossett is clinical practice leader, Anne Smith is nursing practice leader, Marcia K. Gingerich is nurse manager, and Laura Cullen is evidence-based practice scientist, all at the University of Iowa Hospitals and Clinics, Iowa City. Contact author: Angela Dossett, The project described in this article was supported through the Evidence-Based Practice Staff Nurse Internship program at the University of Iowa Hospitals and Clinics. The authors and planners have disclosed no potential conflicts of interest, financial or otherwise.

Background: Yoga-based treatments, which are recognized by the National Institutes of Health's National Center for Complementary and Integrative Health as a form of complementary and alternative medicine, have proven to be beneficial for people with various psychiatric disorders, including depression, anxiety, posttraumatic stress disorder, and attention deficit-hyperactivity disorder, as well as schizophrenia and other psychotic disorders.

Purpose: The purpose of this evidence-based practice (EBP) project was to offer structured yoga sessions as a means of providing stress relief, promoting relaxation, reducing anxiety, and improving quality of care among male and female adult patients (ages 18 years and older) hospitalized in a locked medical-psychiatric unit within an academic medical center for treatment of both acute medical and acute psychiatric conditions.

Practice Change And Implementation: The Iowa Model and Implementation Strategies for EBP provided the guiding framework for this pilot project. Read More

View Article and Full-Text PDF

Prevalence, Influencing Factors, and Clinical Characteristics of Cognitive Impairment in Elderly Patients With Schizophrenia.

Front Psychiatry 2022 6;13:910814. Epub 2022 Jun 6.

Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Aims: The purpose of this study was to investigate the prevalence, influencing factors, and clinical characteristics of cognitive impairment in elderly patients with chronic schizophrenia.

Materials And Methods: A total of 264 elderly patients with chronic schizophrenia and 156 normal controls were enrolled in the current study. The Mini-mental State Examination (MMSE) was used to assess their overall cognitive function, the Positive And Negative Syndrome Scale (PANSS) was used to assess their psychotic symptoms, the Geriatric Depression Scale (GDS) was used to assess their depressive symptoms, while Activity of Daily Living Scale (ADL) was used to assess their daily living ability. Read More

View Article and Full-Text PDF