8,003 results match your criteria Schizophrenia research[Journal]


Altered attentional processing of happy prosody in schizophrenia.

Schizophr Res 2018 Dec 13. Epub 2018 Dec 13.

Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA, United States.

Background: Abnormalities in emotional prosody processing have been consistently reported in schizophrenia. Emotionally salient changes in vocal expressions attract attention in social interactions. However, it remains to be clarified how attention and emotion interact during voice processing in schizophrenia. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.024DOI Listing
December 2018

Hierarchical deficits in auditory information processing in schizophrenia.

Schizophr Res 2018 Dec 12. Epub 2018 Dec 12.

Nathan Kline Institute, Orangeburg, NY, USA; Dept. of Psychiatry, Columbia University Medical Center, New York, NY, USA. Electronic address:

Deficits in auditory processing contribute significantly to impaired functional outcome in schizophrenia (SZ), but mediating factors remain under investigation. Here we evaluated two hierarchical components of early auditory processing: pitch-change detection (i.e. Read More

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http://dx.doi.org/10.1016/j.schres.2018.12.001DOI Listing
December 2018

Off-hours use of a smartphone intervention to extend support for individuals with schizophrenia spectrum disorders recently discharged from a psychiatric hospital.

Schizophr Res 2018 Dec 11. Epub 2018 Dec 11.

The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, NY 11549, USA; Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA.; Department of Psychiatry, Hofstra Northwell School of Medicine, 500 Hofstra Blvd, Hempstead, NY 11549, USA.. Electronic address:

Introduction: Technology-delivered healthcare interventions may enhance dissemination of evidence-based treatments in low-resource areas. These interventions may be accessed 'on-demand,' including after hours. Patients with schizophrenia do engage with technological aids but when/how they would utilize these tools is not known. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.026DOI Listing
December 2018
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Anticipatory pleasure for future rewards is attenuated in patients with schizophrenia but not in individuals with schizotypal traits.

Schizophr Res 2018 Dec 10. Epub 2018 Dec 10.

Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China; School of Applied Psychology and Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia. Electronic address:

The anhedonia paradox is consistently observed in individuals with schizophrenia. However, the underlying mechanism of the dissociation between trait and state hedonic capacity remains unclear. In the present study, we aimed to re-examine anhedonia in patients with schizophrenia (SCZ) and individuals with high schizotypy (HS) using the Monetary Incentive Delay (MID) task to assess different dimensions of anticipatory and consummatory pleasure. Read More

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http://dx.doi.org/10.1016/j.schres.2018.12.003DOI Listing
December 2018

Ventral and dorsal visual pathways exhibit abnormalities of static and dynamic connectivities, respectively, in patients with schizophrenia.

Schizophr Res 2018 Dec 10. Epub 2018 Dec 10.

Medical Imaging Department, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Previous studies suggest that schizophrenia-related visual perceptual abnormalities are primarily attributed to deficits of the dorsal rather than ventral visual pathway. In this study, we comparatively explored changes in dorsal and ventral networks in schizophrenia patients in both static and dynamic functional connectivity (FC). Resting-state MR scans were acquired for forty schizophrenia patients and twenty-four healthy controls matched for age and gender. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09209964183069
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http://dx.doi.org/10.1016/j.schres.2018.12.005DOI Listing
December 2018
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Mediating role of aberrant salience and self-disturbances for the relationship between childhood trauma and psychotic-like experiences in the general population.

Schizophr Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

Introduction: The relationship between childhood trauma and the risk of psychosis is well established. However, the mechanisms of the relationship are still unknown. We investigated whether two factors involved in the risk of psychosis - self-disturbances and aberrant salience - mediate the relationship between childhood trauma and psychotic-like experiences in the general population. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.034DOI Listing
December 2018

Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia.

Schizophr Res 2018 Dec 10. Epub 2018 Dec 10.

NORMENT - K.G. Jebsen Center for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway. Electronic address:

Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern humans. To explore this hypothesis, we used here an evolutionary epigenetics approach building on differentially methylated regions (DMRs) of the genome.

Methods: We implemented a polygenic enrichment testing pipeline using the summary statistics of genome-wide association studies (GWAS) of schizophrenia and 12 other phenotypes. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.025DOI Listing
December 2018

Ventral hippocampal overexpression of Cannabinoid Receptor Interacting Protein 1 (CNRIP1) produces a schizophrenia-like phenotype in the rat.

Schizophr Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmacology and Center for Biomedical Neuroscience, UT Health San Antonio, 7703 Floyd Curl Drive, MC 7764, San Antonio, TX 78229, USA.

Adolescent cannabis use has been implicated as a risk factor for schizophrenia; however, it is neither necessary nor sufficient. Previous studies examining this association have focused primarily on the role of the cannabinoid receptor 1 (CB1R) with relatively little known about a key regulatory protein, the cannabinoid receptor interacting protein 1 (CNRIP1). CNRIP1 is an intracellular protein that interacts with the C-terminal tail of CB1R and regulates its intrinsic activity. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.006DOI Listing
December 2018

Congenital blindness is protective for schizophrenia and other psychotic illness. A whole-population study.

Schizophr Res 2018 Dec 7;202:414-416. Epub 2018 Jul 7.

Centre for Clinical Research in Neuropsychiatry, Division of Psychiatry, Faculty of Health and Medical Sciences, University of Western Australia, Medical Research Foundation Building, Rear 50, Murray Street, Perth 6000, Australia.

Congenital/early blindness is reportedly protective against schizophrenia. Using a whole-population cohort of 467,945 children born in Western Australia between 1980 and 2001, we examined prevalence of schizophrenia and psychotic illness in individuals with congenital/early blindness. Overall, 1870 children developed schizophrenia (0. Read More

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http://dx.doi.org/10.1016/j.schres.2018.06.061DOI Listing
December 2018

Delayed sleep-wake phase disorder and delayed sleep-wake phase in schizophrenia: Clinical and functional correlates.

Schizophr Res 2018 Dec 30;202:412-413. Epub 2018 Jun 30.

Department of Psychiatry and Centre on Behavioral Health, University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2018.06.057DOI Listing
December 2018
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N-methyl-d-aspartate receptor antibody-related pathologies and pre-existent mental state disorders.

Schizophr Res 2018 Dec 29;202:406-407. Epub 2018 Jun 29.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, and Neurology Clinic Unit, IRCCS Polyclinic San Martino Hospital, Genoa, Italy.

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http://dx.doi.org/10.1016/j.schres.2018.06.047DOI Listing
December 2018
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Screening for the ultra-high risk state in a youth mental health service.

Schizophr Res 2018 Dec 29;202:401-403. Epub 2018 Jun 29.

Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, University of Melbourne, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S09209964183038
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http://dx.doi.org/10.1016/j.schres.2018.06.045DOI Listing
December 2018
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Dynamic prediction of transition to psychosis using joint modelling.

Schizophr Res 2018 Dec 7;202:333-340. Epub 2018 Jul 7.

Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, The University of Melbourne, Australia.

Considerable research has been conducted seeking risk factors and constructing prediction models for transition to psychosis in individuals at ultra-high risk (UHR). Nearly all such research has only employed baseline predictors, i.e. Read More

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http://dx.doi.org/10.1016/j.schres.2018.07.002DOI Listing
December 2018

Family burden predicts functional outcome in the early course of schizophrenia beyond psychiatric symptoms and baseline functioning.

Schizophr Res 2018 Dec 7;202:328-332. Epub 2018 Jul 7.

UCLA Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Room 2240, Los Angeles, CA 90095, USA; UCLA Department of Psychology, UCLA, USA. Electronic address:

The goal of this study was to determine if family burden experienced by the families of individuals with a recent-onset of schizophrenia is associated with whether the individual is able to work or attend school during the first year of treatment. Forty-one participants with a recent first episode of schizophrenia and their families enrolled in two NIMH-funded protocols through the UCLA Aftercare Research Program completed a measure of family burden at baseline. Amount of work during this time was also recorded. Read More

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http://dx.doi.org/10.1016/j.schres.2018.06.068DOI Listing
December 2018

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia.

Schizophr Res 2018 Dec 6;202:173-179. Epub 2018 Jul 6.

Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States of America; Department of Psychiatry, University of Cincinnati, United States of America.

Background: Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing. Abnormalities in these hormones are observed in schizophrenia and may contribute to multiple established sex differences associated with the disorder. Here we examined sex-dependent hormone associations with resting brain activity and their clinical associations in schizophrenia patients. Read More

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http://dx.doi.org/10.1016/j.schres.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293995PMC
December 2018
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Impact of lifestyle modification on some components of metabolic syndrome in persons with severe mental disorders: A meta-analysis.

Schizophr Res 2018 Dec 7;202:17-25. Epub 2018 Jul 7.

Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (INI), Bengaluru 560029, Karnataka, India. Electronic address:

Background: Metabolic syndrome (MS) is reportedly associated with high mortality from mostly cardiovascular causes in patients with severe mental disorders (SMD). Lifestyle interventions augment effective management of MS in patients with SMD. The present meta-analysis aims at updating the recent evidence on the effectiveness of lifestyle intervention for MS in patients with SMD. Read More

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http://dx.doi.org/10.1016/j.schres.2018.06.066DOI Listing
December 2018

Hippocampal volume and vasculature before and after exercise in treatment-resistant schizophrenia.

Schizophr Res 2018 Dec 29;202:158-165. Epub 2018 Jun 29.

Department of Radiology, University of British Columbia, Canada. Electronic address:

Background: Schizophrenia is associated with poor cognitive function and elevated cardiometabolic disease risk. These health concerns may exacerbate neurocognitive dysfunction associated with hippocampal abnormalities, particularly hippocampal volume reductions. Regular exercise is thought to improve symptom severity, reduce depression, and improve cognition in schizophrenia, and may trigger exercise-mediated hippocampal growth. Read More

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http://dx.doi.org/10.1016/j.schres.2018.06.054DOI Listing
December 2018

Frontal hypoactivation and alterations in the reward-system during humor processing in patients with schizophrenia spectrum disorders.

Schizophr Res 2018 Dec 30;202:149-157. Epub 2018 Jun 30.

Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Rudolf-Bultmann-Straße 8, 35039 Marburg, Germany.

Humor is a ubiquitous human ability with important implications for both social and emotional functioning. Patients with neuropsychiatric disorders, such as schizophrenia, experience difficulties in the comprehension and appreciation of humor. However, the specific neural mechanisms underlying these deficits are unknown. Read More

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http://dx.doi.org/10.1016/j.schres.2018.06.053DOI Listing
December 2018

Neurobiology of cognitive remediation in schizophrenia: Effects of EAAT2 polymorphism.

Schizophr Res 2018 Dec 29;202:106-110. Epub 2018 Jun 29.

IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.

Cognitive deficits represent core features of schizophrenia, affecting quality of life and functioning. The excitatory amino acid transporter 2 (EAAT2) is responsible for the majority of glutamate reuptake and its activity is crucial for glutamatergic neurotransmission, prevention of excitotoxic damage and cerebral metabolism. Different studies reported that EAAT2 rs4354668 (-181 T/G) influences cognitive functions and brain structures in patients with schizophrenia. Read More

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http://dx.doi.org/10.1016/j.schres.2018.06.059DOI Listing
December 2018
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From "under" to "over" social cognition in schizophrenia: Is there distinct profiles of impairments according to negative and positive symptoms?

Schizophr Res Cogn 2019 Mar 8;15:21-29. Epub 2018 Nov 8.

University Department of Rehabilitation (SUR-CL3R), Le Vinatier hospital, 4 rue Jean Sarrazin, 69008 Lyon, France.

Interactions between social cognition and symptoms of schizophrenia have been investigated, but mostly component by component. Here we tested the assumption that two categories of deficits exist depending on clinical profiles, one corresponding to a defect in social cognition - "under-social cognition" - and one corresponding to excessive attributions leading to social cognitive impairments - "over-social cognition". To conduct the investigation, we performed a Hierarchical Clustering Analysis using positive and negative symptoms in seventy patients with schizophrenia and we compared the clusters obtained to a group of healthy controls on social cognitive measures. Read More

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http://dx.doi.org/10.1016/j.scog.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260279PMC

Bullying victimization in typically developing and clinical high risk (CHR) adolescents: A multimodal imaging study.

Schizophr Res 2018 Dec 7. Epub 2018 Dec 7.

Northwestern University, Department of Psychology, USA; Northwestern University, Department of Psychiatry, USA; Northwestern University, Department of Medical Social Sciences, USA; Northwestern University, Institute for Policy Research, USA; Northwestern University, Institute for Innovations in Developmental Sciences, USA.

Background: Bullying has been shown to increase the risk of developing a psychotic disorder. To date, no studies have examined brain behavior relationships within the context of bullying victimization in clinical high-risk (CHR) youth, a group characterized by both gray and white matter abnormalities. The present study employed multimodal neuroimaging to examine possible neural mechanisms associated with bullying victimization. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.017DOI Listing
December 2018

Cardio-respiratory fitness is associated with a verbal factor across cognitive domains in schizophrenia.

Schizophr Res 2018 Dec 7. Epub 2018 Dec 7.

Division of Mental Health and Addiction, Vestfold Hospital Trust, Tønsberg, Norway; Department of Psychology, University of Oslo, Oslo, Norway.

Objective: We investigated whether the relationship between cardio-respiratory fitness (CRF) and cognition in schizophrenia is general, or due to selective relationships between CRF and specific aspects of cognitive function.

Method: Eighty outpatients with schizophrenia spectrum disorders participated. Neurocognition was assessed with the Wechsler Adult Intelligence Scale version 4 General Ability Index (WAIS GAI), the MATRICS Consensus Cognitive Battery (MCCB) and the Emotion in Biological Motion (EBM) test. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.033DOI Listing
December 2018

Meta-analysis of ghrelin alterations in schizophrenia: Effects of olanzapine.

Schizophr Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychiatry and Health Behavior, Augusta University, Augusta, GA, United States. Electronic address:

Objective: Schizophrenia is associated with an increased prevalence of the metabolic syndrome. Patients receiving antipsychotic medications, including olanzapine, are at further risk. Ghrelin is an appetite-stimulating peptide hormone, although whether blood levels are altered by antipsychotic treatment, remains unclear. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.036DOI Listing
December 2018

Reduced pineal gland volume across the stages of schizophrenia.

Schizophr Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.

A few magnetic resonance imaging (MRI) studies reported reduced pineal gland volume in chronic schizophrenia (Sz), implicating the involvement of melatonin in the pathophysiology of the illness. However, it is not known whether this abnormality, if present, exists at the early illness stages and/or develops progressively over the course of the illness. This MRI study examined pineal gland volume in 64 patients with first-episode schizophrenia (FESz), 40 patients with chronic Sz, 22 individuals with at-risk mental state (ARMS), and 84 healthy controls. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.032DOI Listing
December 2018

Childhood adversities and psychotic symptoms: The potential mediating or moderating role of neurocognition and social cognition.

Schizophr Res 2018 Dec 4. Epub 2018 Dec 4.

Maastricht University Medical Center, Dept. of Psychiatry & Psychology, School for Mental Health & Neuroscience, Maastricht, the Netherlands; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands; King's College London, King's Health Partners, Dept. of Psychosis Studies, Institute of Psychiatry, London, United Kingdom.

Introduction: Childhood abuse and neglect are risk factors for psychotic symptoms. Early adversities may contribute to alterations in neuro/social cognition, which in turn is associated with psychosis. This study explored the possible mediating/moderating role of neuro/social cognition between childhood abuse and neglect on the one hand, and psychotic symptoms on the other. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.028DOI Listing
December 2018

Issue highlights.

Schizophr Res 2018 Dec;202:1-2

Beth Israel Deaconess medical Center and Harvard Medical School, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2018.11.023DOI Listing
December 2018

Investigation of peripheral complement factors across stages of psychosis.

Schizophr Res 2018 Dec 5. Epub 2018 Dec 5.

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia; Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia; Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, VIC, Australia. Electronic address:

The complement cascade has been proposed to contribute to the pathogenesis of schizophrenia. However, it remains unclear whether peripheral complement levels differ in cases compared to controls, change over the course of illness and whether they are associated with current symptomatology. This study aimed to: i) investigate whether peripheral complement protein levels are altered at different stages of illness, and ii) identify patterns among complement protein levels that predict clinical symptoms. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.035DOI Listing
December 2018

An investigation into the relationship between clozapine treatment and cognitive performance in patients with treatment resistant schizophrenia.

Schizophr Res 2018 Dec 5. Epub 2018 Dec 5.

Rehabilitation Academic Clinical Unit, Metro South Mental Health and Addiction Services, Brisbane, Qld, Australia; School of Medicine, The University of Queensland, Brisbane, Qld, Australia.

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http://dx.doi.org/10.1016/j.schres.2018.11.030DOI Listing
December 2018

Excess medical comorbidity and mortality across the lifespan in schizophrenia.: A nationwide Danish register study.

Schizophr Res 2018 Dec 5. Epub 2018 Dec 5.

Research Unit of Psychiatry, Institute of Clinical Research, University of Southern Denmark, Sdr. Boulevard 29, 5000 Odense C, Denmark.

Introduction: People with severe mental illness have greater risk of un-detected and inadequately treated medical disorders, adding up to the risk of premature death. This study investigated how chronic medical comorbidity evolved across the lifespan in schizophrenia and the associated impact on mortality.

Method: A register-based retrospective nested case-control study was conducted, identifying incident cases of cardiovascular disease (CVD), chronic obstructive pulmonary disease (COPD), cancer and diabetes, as well as mortality due to these diseases, across the lifespan in schizophrenia. Read More

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http://dx.doi.org/10.1016/j.schres.2018.10.020DOI Listing
December 2018

Weight gain and metabolic change as predictors of symptom improvement in first-episode schizophrenia spectrum disorder patients treated over 12 months.

Schizophr Res 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry, Stellenbosch University, South Africa.

Background: Treatment-emergent weight gain is associated with antipsychotic efficacy in schizophrenia patients treated with clozapine and olanzapine. However, few studies have investigated this relationship in first-episode patients treated with other antipsychotics, in particular those with a lower obesogenic potential. Aim To investigate the relationships between weight gain and associated metabolic changes with psychopathology improvement in relation to age, sex, ethnicity, substance use, treatment duration and antipsychotic dose in first-episode schizophrenia spectrum disorder patients. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.031DOI Listing
November 2018
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Plasma protein levels of brain-derived neurotrophic factor pathways and their association with cognitive performance in patients with clinical high risk for psychosis and first episode psychosis.

Schizophr Res 2018 Nov 28. Epub 2018 Nov 28.

Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Mental Health Institute of Central South University, Changsha, Hunan 410011, China; China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan 410011, China; China National Technology Institute on Mental Disorders, Changsha, Hunan 410011, China. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2018.11.016DOI Listing
November 2018

Anomalies of imagination in the schizophrenia-spectrum: Empirical findings.

Schizophr Res 2018 Nov 28. Epub 2018 Nov 28.

Mental Health Center Glostrup, University of Copenhagen, Broendbyostervej 160, 2605 Broendby, Denmark; Center for Subjectivity Research, University of Copenhagen, Karen Blixens Plads 8, 2300 Copenhagen S, Denmark.

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http://dx.doi.org/10.1016/j.schres.2018.11.019DOI Listing
November 2018
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Clozapine-induced myocarditis in Canada: Evidence from spontaneous reports.

Schizophr Res 2018 Dec 1. Epub 2018 Dec 1.

Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09209964183066
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http://dx.doi.org/10.1016/j.schres.2018.11.015DOI Listing
December 2018
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Overestimated function in patients with schizophrenia: A possible risk factor for inadequate support?

Schizophr Res 2018 Dec 1. Epub 2018 Dec 1.

Department of Psychiatry, NU-Hospital Group, Trollhättan, Sweden; Department of Psychology, Karlstad University, Karlstad, Sweden.

People with schizophrenia often demonstrate an impaired ability to assess and report aspects of their everyday functioning, and the aim of this study is to investigate how patients' self-rating ability regarding functional performance relates to neurocognitive performance and real-world functional performance. A total of 222 outpatients with a schizophrenia spectrum disorder participated in this study. They were divided into groups based on their self-rating ability (determined using self-rating questions) and their observed functional capacity (the UCSD Performance-Based Skills Assessment-Brief, UPSA-B). Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.027DOI Listing
December 2018
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Cognitive capacity similarly predicts insight into symptoms in first- and multiple-episode psychosis.

Schizophr Res 2018 Dec 1. Epub 2018 Dec 1.

Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada; Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada. Electronic address:

Background: Lack of insight is a frequent characteristic of psychotic disorders, both in patients who recently experienced a first episode of psychosis (FEP) and those who experience recurrent multiple episodes (MEP). Insight is a multifaceted construct: its clinical form notably includes the unawareness of being ill, of symptoms, and of the need for treatment. Cognitive capacity is among the key determinants of insight into symptoms, but less is known about whether stage of illness (FEP vs. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.013DOI Listing
December 2018
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Clinical correlates of subsyndromal depression in African American individuals with psychosis: The relationship with positive symptoms and comorbid substance dependence.

Schizophr Res 2018 Oct 26. Epub 2018 Oct 26.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA.

Patients with psychosis exhibit subsyndromal depressive symptoms during the course of illness and yet the clinical correlates of these symptoms remain under-investigated. We aimed to investigate the clinical correlates of subsyndromal depression in psychosis including the extent to which they mediate commonly observed comorbid substance dependence. We developed a model of depression in a non-clinical sample recruited via Amazon's Mechanical Turk (N = 266), and confirmed that model in a locally recruited African-American clinical sample comprising psychotic and non-psychotic individuals (N = 256). Read More

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http://dx.doi.org/10.1016/j.schres.2018.10.022DOI Listing
October 2018
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Body mass index trajectories in childhood and adolescence - Risk for non-affective psychosis.

Schizophr Res 2018 Oct 25. Epub 2018 Oct 25.

Department of Psychiatry, University of Turku, Turku, Finland; General Hospital Psychiatry Unit, Turku University Hospital, Turku, Finland and Turku Psychiatry, Turku, Finland. Electronic address:

Background: Underweight in early adulthood increases risk for schizophrenia, but the effect of early childhood underweight on psychosis risk is not well known.

Methods: We studied whether underweight or overweight in childhood and adolescence increases risk for non-affective psychosis or other psychiatric disorders in a population-based cohort study 'Cardiovascular Risk in Young Finns'. Body mass index (BMI) trajectories were recorded in the years 1980, 1983 and 1986 (in 3-18 years of age), before the first hospitalization due to a psychiatric disorder. Read More

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http://dx.doi.org/10.1016/j.schres.2018.10.025DOI Listing
October 2018
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Persistent negative symptoms in individuals at Ultra High Risk for psychosis.

Schizophr Res 2018 Oct 26. Epub 2018 Oct 26.

Telethon Kids Institute, Australia.

Persistent negative symptoms (PNS) defined as negative symptoms that persist for at least six months in the absence of high levels of positive, depressive and extrapyramidal symptoms, are evident early in the course of schizophrenia from the first episode of psychosis. However, their presence even earlier in the illness, in those at Ultra High Risk of psychosis, has not been investigated. In this study, we examined the prevalence, baseline correlates and outcome of PNS in 363 Ultra High Risk individuals. Read More

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http://dx.doi.org/10.1016/j.schres.2018.10.019DOI Listing
October 2018
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Herpes simplex virus 1 infection and valacyclovir treatment in schizophrenia: Results from the VISTA study.

Schizophr Res 2018 Nov 23. Epub 2018 Nov 23.

Sheppard Pratt Health System, Baltimore, MD, United States of America.

Background: Several studies have implicated herpes simplex virus-type 1 (HSV-1) in the pathophysiology of schizophrenia. A recent trial demonstrated that the anti-viral medication valacylovir, which prevents replication of activated HSV-1, improved selected cognitive deficits in people with schizophrenia. In this study, we examined demographic and illness related differences between HSV-1 positive versus HSV-1 negative subjects with early phase schizophrenia and attempted to replicate the previous valacyclovir treatment results in this population. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.002DOI Listing
November 2018

Abnormalities in the evoked frontal oscillatory activity of first-episode psychosis: A TMS/EEG study.

Schizophr Res 2018 Nov 22. Epub 2018 Nov 22.

Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil.

TMS with simultaneous EEG allows assessing the intrinsic oscillatory activity of cortical neurons. We recently showed reduced frontal cortical oscillations in chronic schizophrenia (SCZ). Here we investigated the oscillatory activity of first-episode psychosis (FEP) patients after TMS of a frontal area, the motor cortex. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.008DOI Listing
November 2018

Maternal transmission of CNTN6 copy number variation suggests mitochondrial disorder.

Schizophr Res 2018 Nov 23. Epub 2018 Nov 23.

Disciplina de Neurociência, Escola Paulista de Medicine/Universidade Federal de São Paulo (EPM/UNIFESP). São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.schres.2018.11.021DOI Listing
November 2018
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Social dysfunction in preclinical, at risk stages of psychosis: A developmental view.

Schizophr Res 2018 Nov 23. Epub 2018 Nov 23.

Department of Medicine, Division of Psychiatry, Clinical Psychology and Rehabilitation, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.schres.2018.11.020DOI Listing
November 2018

Can N‑acetylcysteine, varenicline, or the combination prevent psychosis by enhancing mismatch negativity?

Schizophr Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, Washington, DC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2018.11.022DOI Listing
November 2018
3.923 Impact Factor

Shared multisensory experience affects Others' boundary: The enfacement illusion in schizophrenia.

Schizophr Res 2018 Nov 23. Epub 2018 Nov 23.

Department of Medicine and Surgery, University of Parma, Parma, Italy; Institute of Philosophy, School of Advanced Study, University of London, London, UK.

Schizophrenia has been described as a psychiatric condition characterized by deficits in one's own and others' face recognition, as well as by a disturbed sense of body-ownership. To date, no study has integrated these two lines of research with the aim of investigating Enfacement Illusion (EI) proneness in schizophrenia. To accomplish this goal, the classic EI protocol was adapted to test the potential plasticity of both Self-Other and Other-Other boundaries. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.018DOI Listing
November 2018
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Predicting work outcome in patients with schizophrenia: Influence of IQ decline.

Schizophr Res 2018 Nov 4;201:172-179. Epub 2018 Jul 4.

Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.

Background: Patients with schizophrenia show various trajectories in intelligence. However, whether the degree of IQ decline is associated with functional outcomes remains unclear. The purposes of the study were 1) to determine whether IQ decline was related with work outcome, and 2) to perform predictions for attaining a certain amount of work measured by work hours. Read More

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http://dx.doi.org/10.1016/j.schres.2018.05.042DOI Listing
November 2018
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Goal-directed planning and action impairments in schizophrenia evaluated in a virtual environment.

Schizophr Res 2018 Nov 22. Epub 2018 Nov 22.

Schizophrenia Division and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College St., Toronto, Ontario M5T 1R8, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada; Department of Psychiatry, University of Toronto, 250 College St., Toronto, Ontario M5T 1R8, Canada.

Planning and executing goal-directed behaviours are critical final steps in translating motivation into action. Amotivation is a key feature of schizophrenia, but its impact on goal-directed functioning has not been extensively studied in an objective and ecologically valid manner. To address this, we investigated goal-directed planning and action in schizophrenia using a virtual reality task, the Multitasking in the City Test (MCT). Read More

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http://dx.doi.org/10.1016/j.schres.2018.10.012DOI Listing
November 2018
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Characteristics and outcomes of young people with substance induced psychotic disorder.

Schizophr Res 2018 Nov 21. Epub 2018 Nov 21.

Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, University of Melbourne, Australia; Orygen Youth Health, 35 Poplar Rd, Parkville, VIC 3025, Australia. Electronic address:

Background: Substance induced psychotic disorders (SIPD) have been historically considered as associated with better clinical and functional outcomes than other psychotic diagnoses. As a result, treatments for those with SIPD are often considerably less intensive, yet this is not based on evidence. The present study aimed to examine whether differences exist between those with SIPD and other first episode psychosis (FEP) diagnoses in regards to demographic and clinical factors, and to determine the symptomatic, clinical and functional outcomes in those with SIPD. Read More

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http://dx.doi.org/10.1016/j.schres.2018.11.007DOI Listing
November 2018
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An approach to sample size calculation for research on duration of untreated psychosis.

Schizophr Res 2018 Nov 21. Epub 2018 Nov 21.

Douglas Mental Health University Institute, McGill University, Verdun, Quebec, Canada; McGill University, Department of Psychiatry, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.schres.2018.11.012DOI Listing
November 2018

Plasma metabolites in first episode psychoses.

Schizophr Res 2018 Nov 20. Epub 2018 Nov 20.

Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, University of Sao Paulo Medical School, Brazil; Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBioN), Conselho Nacional de Desenvolvimento Cientifico e Tecnológico, Sao Paulo, Brazil.

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http://dx.doi.org/10.1016/j.schres.2018.11.010DOI Listing
November 2018
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