8,160 results match your criteria Schizophrenia research[Journal]


Evidence of reward system dysfunction in youth at clinical high-risk for psychosis from two event-related fMRI paradigms.

Schizophr Res 2019 Apr 14. Epub 2019 Apr 14.

Maryland Psychiatric Research Center, University of Maryland School of Medicine, A55 Wade Ave, Catonsville, MD 21228, United States of America.

Abnormal reward processing is thought to play an important role in the development of psychosis, but relatively few studies have examined reward prediction errors, reinforcement learning (RL), and the reward circuitry that subserves these interconnected processes among individuals at clinical high-risk (CHR) for the disorder. Here, we present behavioral and functional neuroimaging results of two experimental tasks designed to measure overlapping aspects of reward processing among individuals at CHR (n = 22) and healthy controls (n = 19). We found no group differences in in response times to positive, negative, or neutral outcome-signaling cues, and no significant differences in brain activation during reward anticipation or receipt. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.017DOI Listing

A comparison of simple reaction times in psychotic inpatients with and without hyponatremia.

Schizophr Res 2019 Apr 13. Epub 2019 Apr 13.

Translational Neuroscience, Conshohocken, PA 19428, USA; Drexel University College of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.schres.2019.04.001DOI Listing

Validation of the Brief Negative Symptom Scale and its association with functioning.

Schizophr Res 2019 Apr 13. Epub 2019 Apr 13.

Research Division, Institute of Mental Health, Singapore; North Region & Department of Psychosis, Institute of Mental Health, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address:

Introduction: The Brief Negative Symptom Scale (BNSS) includes five domains of negative symptoms suggested by the NIMH Consensus Development Conference (anhedonia, asociality, avolition, blunted affect, and alogia), which could be clustered into two factors - Motivation-Pleasure (MAP) and Emotional Expressivity (EE). Our study aims to examine the psychometric properties of BNSS, and its association with functioning.

Methods: 274 individuals with schizophrenia were assessed on the BNSS, Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Global Assessment of Functioning Scale (GAF), Calgary Depression Scale for Schizophrenia (CDSS), and Simpson-Angus Extrapyramidal Side Effects Scale (SAS). Read More

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http://dx.doi.org/10.1016/j.schres.2019.04.005DOI Listing

Evidence of brain network aberration in healthy subjects with urban upbringing - A multimodal DTI and VBM study.

Schizophr Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Psychiatry and Psychotherapy, Marburg University, Germany.

City living represents not only the allegory of modern life, but also - due to attractive living conditions, employment and infrastructure - a crucial reality for a growing portion of the global society. Regarding the remarkable increase of the schizophrenia incidence in individuals exposed to an urban environment during upbringing the understanding of responsible pathogenetic mechanisms is important. Schizophrenia has been conceptualized as a disorder of brain dysconnectivity. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.027DOI Listing

Relationship between neuropsychological behavior and brain white matter in first-episode psychosis.

Schizophr Res 2019 Apr 13. Epub 2019 Apr 13.

Department Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Mental Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.

We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition (processing speed, attention/working memory, and executive functioning) and FA at the deep (cerebral peduncles, sagittal striatum, uncinate, internal/external capsule, cingulum) and peripheral white matter (adjacent to inferior temporal, angular, supramarginal, insula, occipital, rectus gyrus). Read More

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http://dx.doi.org/10.1016/j.schres.2019.04.010DOI Listing

The abiding relevance of mouse models of rare mutations to psychiatric neuroscience and therapeutics.

Schizophr Res 2019 Apr 12. Epub 2019 Apr 12.

Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, New York, NY 10027, USA; Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Studies using powerful family-based designs aided by large scale case-control studies, have been instrumental in cracking the genetic complexity of the disease, identifying rare and highly penetrant risk mutations and providing a handle on experimentally tractable model systems. Mouse models of rare mutations, paired with analysis of homologous cognitive and sensory processing deficits and state-of-the-art neuroscience methods to manipulate and record neuronal activity have started providing unprecedented insights into pathogenic mechanisms and building the foundation of a new biological framework for understanding mental illness. A number of important principles are emerging, namely that degradation of the computational mechanisms underlying the ordered activity and plasticity of both local and long-range neuronal assemblies, the building blocks necessary for stable cognition and perception, might be the inevitable consequence and the common point of convergence of the vastly heterogeneous genetic liability, manifesting as defective internally- or stimulus-driven neuronal activation patterns and triggering the constellation of schizophrenia symptoms. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.018DOI Listing

Neuroprotective effects of the second generation antipsychotics.

Schizophr Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, 1438 South Grand Blvd., Suite 105, Saint Louis, MO, USA. Electronic address:

Background: In contrast to over 30 studies reporting neurotoxicity associated with the first-generation antipsychotics (FGAs), several published studies have reported multiple neuroprotective effects associated with the second generation antipsychotics (SGAs). This prompted us to conduct a review of the reported neuroprotective mechanisms of the SGA class of antipsychotics compared to the FGAs.

Methods: A PubMed search was conducted using the keywords antipsychotic, neuroprotection, neuroplasticity, neurogenesis, neurotoxicity, toxicity, brain volume, neuroinflammation, oxidative stress, myelin, and oligodendrocyte. Read More

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http://dx.doi.org/10.1016/j.schres.2019.04.009DOI Listing

Normal categorical perception to syllable-like stimuli in long term and in first episode schizophrenia.

Schizophr Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Psychiatry, University of Pittsburgh, Suite 420, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA. Electronic address:

Schizophrenia is associated with deficits in language processing that are evident even at first-episode. However, there is debate as to how early in the processing stream the linguistic deficits appear. We measured categorical processing of artificial syllables that varied in voice-onset time (VOT), and how sensory biasing impacts categorical perception. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.028DOI Listing

Retinal single-layer analysis with optical coherence tomography (OCT) in schizophrenia spectrum disorder.

Schizophr Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurology, University Clinic Ulm, Germany.

Background: Volume reductions in brain structures of patients with schizophrenia spectrum disorder (SSD) have repeatedly been found in voxel-based morphometry MRI studies. Hence, an underlying neurodegenerative etiological component of SSD is currently being discussed. In recent years, the imaging method of optical coherence tomography (OCT) has shown its potential in evaluating structural changes in the retina in patients with confirmed neurodegenerative disorders, providing a window into the brain. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.022DOI Listing
April 2019
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Cross-sectional study of diet patterns in early and chronic schizophrenia.

Schizophr Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Psychiatry, University of Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.03.029DOI Listing
April 2019
3.923 Impact Factor

NMDA receptor hypofunction for schizophrenia revisited: Perspectives from epigenetic mechanisms.

Schizophr Res 2019 Apr 9. Epub 2019 Apr 9.

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, United States of America. Electronic address:

Schizophrenia (SZ) is a neurodevelopmental disorder with cognitive deficits manifesting during early stages of the disease. Evidence suggests that genetic factors in combination with environmental insults lead to complex changes to glutamatergic, GABAergic, and dopaminergic systems. In particular, the N-methyl-d-aspartate receptor (NMDAR), a major glutamate receptor subtype, is implicated in both the disease progression and symptoms of SZ. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09209964193010
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http://dx.doi.org/10.1016/j.schres.2019.03.010DOI Listing
April 2019
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Differentiating implicit and explicit theory of mind and associated neural networks in youth at Clinical High Risk (CHR) for psychosis.

Schizophr Res 2019 Apr 9. Epub 2019 Apr 9.

Northwestern University Department of Psychology, USA; Northwestern University Department of Psychiatry, USA; Northwestern University Department of Medical Social Sciences, USA; Northwestern University Institute for Innovations in Developmental Sciences, USA; Northwestern University Institute for Policy Research, USA.

Background: Theory of mind (ToM) has been shown to be impaired in Clinical High Risk (CHR) for psychosis populations and is linked to functional outcomes and symptom severity. Implicit versus explicit ToM has seldom been differentiated in this group, and underlying neural networks have also gone unexplored.

Methods: 24 CHR and 26 healthy volunteers (HV) completed a behavioral ToM measure called the Short Story Task (SST), as well as a resting state functional MRI scan. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.013DOI Listing

No alteration in leukocyte telomere length in schizophrenia; evidence from a meta-analysis.

Schizophr Res 2019 Apr 9. Epub 2019 Apr 9.

Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09209964193012
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http://dx.doi.org/10.1016/j.schres.2019.04.004DOI Listing
April 2019
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Outcome of a psychosocial health promotion intervention aimed at improving physical health and reducing alcohol use in patients with schizophrenia and psychotic disorders (MINT).

Schizophr Res 2019 Apr 9. Epub 2019 Apr 9.

Dept of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

Background: Life expectancy is reduced by 19 years in men and 17 in women with psychosis in Sweden, largely due to cardiovascular disease.

Aim: Assess whether a psychosocial health promotion intervention improves cardiometabolic risk factors, quality of life, and severity of illness in patients with psychotic disorders more than treatment as usual.

Methods: A pragmatic intervention trial testing a manual-based multi-component health promotion intervention targeting patients with psychosis. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.026DOI Listing

Feasibility of using a smartphone app to assess early signs, basic symptoms and psychotic symptoms over six months: A preliminary report.

Schizophr Res 2019 Apr 9. Epub 2019 Apr 9.

Greater Manchester Mental Health NHS Foundation Trust, Bury New Road, Prestwich, Manchester, Greater Manchester M25 3BL, United Kingdom; University of Manchester, Division of Psychology and Mental Health, Jean McFarlane Building (3(rd) Floor), Manchester M13 9L, United Kingdom. Electronic address:

Background: Psychosis relapses are common, have profound adverse consequences for patients, and are costly to health services. 'Early signs' have been used to predict relapse, in the hope of prevention or mitigation, with moderate sensitivity and specificity. We investigated the feasibility and validity of adding 'basic symptoms' to conventional early signs and monitoring these using a smartphone app. Read More

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http://dx.doi.org/10.1016/j.schres.2019.04.003DOI Listing

Cognitive impairment and its improvement after six months in adolescents with schizophrenia.

Schizophr Res Cogn 2019 Sep 26;17:100135. Epub 2019 Mar 26.

Child Psychiatric Hospital, Mexico City, Mexico.

Studies evaluating the cognitive impairment in schizophrenic adolescents reported a variable course following antipsychotic treatment, with improvement being associated to patients' demographic or clinical characteristics.

Objectives: To examine the cognitive impairments of a Mexican sample of adolescents with schizophrenia using the MATRICS Consensus Cognitive Battery (MCCB) before and after six months of antipsychotic treatment and to determine which demographic or clinical characteristics could be associated to cognitive improvement.

Methods: A sample of 87 Mexican patients was evaluated with the MCCB. Read More

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http://dx.doi.org/10.1016/j.scog.2019.100135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439271PMC
September 2019
1 Read

Effect of second-generation antipsychotics on brain network topology in first-episode schizophrenia: A longitudinal rs-fMRI study.

Schizophr Res 2019 Apr 7. Epub 2019 Apr 7.

Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address:

Objective: We aimed to evaluate the functional network properties in first-episode schizophrenia (SZ) patients at baseline and after 4-months treatment with second-generation antipsychotic drugs.

Methods: Resting-state functional magnetic resonance imaging and graph theory approaches were utilized to evaluate the functional integration and segregation of brain networks in 36 first-episode patients (20 male/16 female) with SZ and 36 age and sex matched healthy controls (20 male/16 female).

Results: Compared with healthy controls, SZ at baseline showed lower clustering coefficient (C) and local network efficiency (E), and this abnormal pattern was modulated with treatment of antipsychotic drugs at follow-up. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.015DOI Listing
April 2019
4 Reads

Meta-analysis of cytokine and C-reactive protein levels in high-risk psychosis.

Schizophr Res 2019 Apr 7. Epub 2019 Apr 7.

Department of Psychiatry and Health Behavior, Augusta University, Augusta, GA, United States. Electronic address:

Objective: Schizophrenia is associated with aberrant blood cytokine and C-reactive protein (CRP) levels. However, less is known about alterations in these markers prior to the onset of psychosis. We performed a meta-analysis of blood cytokines and CRP in subjects at high-risk for psychosis. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.012DOI Listing
April 2019
6 Reads

The ketogenic diet and remission of psychotic symptoms in schizophrenia: Two case studies.

Schizophr Res 2019 Apr 6. Epub 2019 Apr 6.

Duke Lifestyle Medical Clinic, USA; Duke Medical School, USA.

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http://dx.doi.org/10.1016/j.schres.2019.03.019DOI Listing
April 2019
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Adjunct transcranial direct current stimulation improves cognitive function in patients with schizophrenia: A double-blind 12-week study.

Schizophr Res 2018 Jul;197:378-385

Department of Psychiatry, Busan Paik Hospital, Inje University, Busan, Republic of Korea.

Objectives: Cognitive impairment is a common symptom of schizophrenia that has significant effects on quality of life and the activities of daily living. The present study examined the ability of transcranial direct current stimulation (tDCS) to improve cognitive function and clinical symptoms in patients with schizophrenia.

Methods: Fifty-six patients with schizophrenia were randomized to real-tDCS and sham-tDCS groups. Read More

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http://dx.doi.org/10.1016/j.schres.2017.12.009DOI Listing

Towards a framework for good outcome in people at clinical high risk for psychosis: A Delphi consensus study.

Schizophr Res 2019 Apr 1. Epub 2019 Apr 1.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Background: Outcomes in people at clinical high risk for psychosis (CHRP) have usually been defined in terms of psychosis onset. However, within the subgroup of individuals who do not develop psychosis, some have persistent symptoms; while in others, symptoms resolve and functioning is restored. Currently, little is known about what predicts a good outcome (GO) in CHR-P individuals, partly because there is no consensus on how this should be defined. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.019DOI Listing
April 2019
3.923 Impact Factor

Relationships between smartphone social behavior and relapse in schizophrenia: A preliminary report.

Schizophr Res 2019 Mar 30. Epub 2019 Mar 30.

Behavioral Research in Technology and Engineering (BRiTE) Center, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States of America.

Social dysfunction is a hallmark of schizophrenia. Social isolation may increase individuals' risk for psychotic symptom exacerbation and relapse. Monitoring and timely detection of shifts in social functioning are hampered by the limitations of traditional clinic-based assessment strategies. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.014DOI Listing

The relationship between childhood abuse and severity of psychosis is mediated by loneliness: an experience sampling study.

Schizophr Res 2019 Mar 30. Epub 2019 Mar 30.

Rivierduinen Psychiatric Institute, Sandifortdreef 19, 2333 ZZ Leiden, the Netherlands; Department of Psychiatry and Neuropsychology, Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, the Netherlands.

Background: This study tested the hypotheses that (i) the relationship between a history of childhood abuse and severity of psychosis is mediated by loneliness; (ii) the relationship between loneliness and psychosis is mediated by within-person fluctuations in depressive and anxious feelings.

Methods: Fifty-nine individuals with non-affective psychotic disorder rated the intensity of loneliness, positive symptoms, and depressive and anxious feelings during repeated moments in daily life (Experience Sampling Method). Childhood abuse was assessed retrospectively using the 'Childhood Experience of Care and Abuse' interview. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.021DOI Listing

Candidate metabolic biomarkers for schizophrenia in CNS and periphery: Do any possible associations exist?

Schizophr Res 2019 Mar 29. Epub 2019 Mar 29.

Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China; The Institute of Clinical Pharmacy, Central South University, Changsha 410011, Hunan, China. Electronic address:

Due to the limitations of analytical techniques and the complicity of schizophrenia, nowadays it is still a challenge to diagnose and stratify schizophrenia patients accurately. Many attempts have been made to identify and validate available biomarkers for schizophrenia from CSF and/or peripheral blood in clinical studies with consideration to disease stages, antipsychotic effects and even gender differences. However, conflicting results handicap the validation and application of biomarkers for schizophrenia. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.009DOI Listing

Recovery from daily-life stressors in early and chronic psychosis.

Schizophr Res 2019 Mar 28. Epub 2019 Mar 28.

Department of Neurosciences, Center for Contextual Psychiatry, KU Leuven, Leuven, Belgium.

Initial affective and psychotic reactivity to daily stressors is altered in psychosis, and most notably in early psychosis. In addition to altered initial stress reactivity, results from studies using Experience Sampling Methodology (ESM) and psychophysiological measures indicate that impaired recovery from mild stressors may also be a risk factor for mental illness. The current ESM study investigated affective recovery from daily stressors in chronic psychosis patients (CP; n = 162), individuals at early stages of psychosis (EP; n = 127), and healthy volunteers (HV; n = 220) assessing fluctuations in negative affect (NA), tension, and suspiciousness ten times a day on six consecutive days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09209964193010
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http://dx.doi.org/10.1016/j.schres.2019.03.011DOI Listing
March 2019
2 Reads

Neuroplasticity and dysplasticity processes in schizophrenia.

Schizophr Res 2019 Mar 28. Epub 2019 Mar 28.

Department of Psychiatry, University of Minnesota, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.03.008DOI Listing
March 2019
1 Read

Evaluation of a plasticity-based cognitive training program in schizophrenia: Results from the eCaesar trial.

Schizophr Res 2019 Mar 28. Epub 2019 Mar 28.

Duke University, United States of America.

Objective: Cognitive impairment in schizophrenia is a core feature of the disorder. Computerized cognitive training has shown promise in pilot studies. A 26-week randomized blinded placebo-controlled trial was conducted to investigate the effect of a novel computerized cognitive training program on cognitive and functional capacity outcomes. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.006DOI Listing
March 2019
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The three-dimensional landscape of the genome in human brain tissue unveils regulatory mechanisms leading to schizophrenia risk.

Authors:
Won Mah Hyejung Won

Schizophr Res 2019 Mar 17. Epub 2019 Mar 17.

Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

Recent advances in our understanding of the genetic architecture of schizophrenia have shed light on the schizophrenia etiology. While common variation is one of the major genetic contributors, the majority of common variation reside in non-coding genome, posing a significant challenge in understanding the functional impact of this class of genetic variation. Functional genomic datasets that range from expression quantitative trait loci (eQTL) to chromatin interactions are critical to identify the potential target genes and functional consequences of non-coding variation. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.007DOI Listing

Childhood trauma and adolescent psychotic experiences in a community-based cohort: The potential role of positive attributes as a protective factor.

Schizophr Res 2019 Mar 28;205:23-29. Epub 2018 Jun 28.

Department of Psychiatry, Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Universidade Federal de São Paulo, São Paulo, Brazil; National Institute of Developmental Psychiatry, São Paulo, Brazil; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.

Objective: To investigate how a set of positive social and personality characteristics called 'positive attributes' affects the emergence and persistence of Psychotic Experiences (PE) in adolescence.

Method: We used data from a community-based Brazilian High-Risk Cohort (HRC). 2511 6-12 year-old children were evaluated at baseline, and 80. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09209964183038
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http://dx.doi.org/10.1016/j.schres.2018.06.044DOI Listing
March 2019
2 Reads

Insight in schizophrenia, its fundamental connection to fragmentation and potential as a treatment target: A commentary on Phahladira et al.

Schizophr Res 2019 Mar 13. Epub 2019 Mar 13.

Indiana University School of Medicine, United States of America.

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http://dx.doi.org/10.1016/j.schres.2019.03.005DOI Listing

Pro-cognitive effect of a prebiotic in psychosis: A double blind placebo controlled cross-over study.

Schizophr Res 2019 Mar 12. Epub 2019 Mar 12.

Department of Psychiatry, University of Oxford, Oxford OX3 7JX, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.03.003DOI Listing

Ndel1 oligopeptidase activity as a potential biomarker of early stages of schizophrenia.

Schizophr Res 2019 Mar 8. Epub 2019 Mar 8.

Department of Pharmacology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Brazil. Electronic address:

Our previous studies showed reduced Ndel1 enzyme activity in patients with chronic schizophrenia (SCZ), and only a subtle NDEL1 mRNA increases in antipsychotic-naïve first-episode psychosis (FEP) individuals compared to matched healthy controls (HC). Aiming to refine the evaluation of Ndel1 enzyme activity in early stages of psychosis, we compared 3 groups composed by (1) subjects at ultra-high-risk (UHR) for psychosis, (2) a cohort comprising antipsychotic-naïve FEP individuals (assessed in three moments, at baseline (FEP-0), and after 2 months (FEP-2 M) and one year (FEP-1Y) of treatment with risperidone), and (3) a HC group. There was no significant difference in Ndel1 enzyme activity between UHR and HC, but this activity was significantly lower in FEP compared to HC. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.021DOI Listing
March 2019
2 Reads

Genetic variability of glutamate reuptake: Effect on white matter integrity and working memory in schizophrenia.

Schizophr Res 2019 Mar 8. Epub 2019 Mar 8.

IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1016/j.schres.2019.03.004DOI Listing

Short duration of marriage at conception as an independent risk factor for schizophrenia.

Schizophr Res 2019 Mar 8. Epub 2019 Mar 8.

Unit of Epidemiology, School of Public Health, Hebrew University of Jerusalem, Israel.

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09209964193008
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http://dx.doi.org/10.1016/j.schres.2019.03.001DOI Listing
March 2019
13 Reads
3.923 Impact Factor

A developmental redox dysregulation leads to spatio-temporal deficit of parvalbumin neuron circuitry in a schizophrenia mouse model.

Schizophr Res 2019 Mar 8. Epub 2019 Mar 8.

Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital-CHUV, Prilly-Lausanne, Switzerland. Electronic address:

The fast-spiking parvalbumin (PV) interneurons play a critical role in neural circuit activity and dysfunction of these cells has been implicated in the cognitive deficits typically observed in schizophrenia patients. Due to the high metabolic demands of PV neurons, they are particularly susceptible to oxidative stress. Given the extant literature exploring the pathological effects of oxidative stress on PV cells in cortical regions linked to schizophrenia, we decided to investigate whether PV neurons in other select brain regions, including sub-cortical structures, may be differentially affected by redox dysregulation induced oxidative stress during neurodevelopment in mice with a genetically compromised glutathione synthesis (Gclm KO mice). Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.017DOI Listing
March 2019
1 Read

A polymorphism of the methylenetetrahydrofolate reductase gene confers susceptibility to schizophrenia and related brain changes.

Schizophr Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan.

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http://dx.doi.org/10.1016/j.schres.2019.03.002DOI Listing

Association between developmental milestones and age of schizophrenia onset: Results from the Northern Finland Birth Cohort 1966.

Schizophr Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Psychiatry, University of Cambridge, Cambridge, UK; National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care East of England, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK. Electronic address:

We investigated relationships between early developmental milestones, schizophrenia incidence and variability in its age at onset. We hypothesized that the period of risk for schizophrenia would be longer for those with later development. The Northern Finland Birth Cohort 1966 was followed until 47 years of age, and those members diagnosed with schizophrenia or any other non-affective psychoses identified. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.013DOI Listing

A Genetics Perspective on the Role of the (Neuro)Immune System in Schizophrenia.

Schizophr Res 2019 Mar 5. Epub 2019 Mar 5.

Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, United States of America; Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD, United States of America; Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, United States of America; Johns Hopkins University School of Medicine, Institute of Genomics Medicine, Baltimore, MD, United States of America; Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD, United States of America. Electronic address:

The immune system has long been hypothesized to play a role in schizophrenia pathogenesis based on data from diverse disciplines. Recent reports of the identification of schizophrenia-associated genetic variants and their initial biological characterization have renewed investigation of the role of the immune system in schizophrenia. In the current review, the plausibility of a role of the immune system in schizophrenia pathogenesis is examined, by revisiting epidemiology, neuroimaging, pharmacology, and developmental biology from a genetics perspective, as well as by synthesizing diverse findings from the emerging and dynamic schizophrenia genomics field. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.005DOI Listing

Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.

Schizophr Res 2019 Mar 2. Epub 2019 Mar 2.

International Mood & Psychotic Disorders Research Consortium, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.schres.2019.02.020DOI Listing
March 2019
3 Reads

Successful treatment of clozapine-nonresponsive refractory hallucinations and delusions with pimavanserin, a serotonin 5HT-2A receptor inverse agonist.

Schizophr Res 2019 Mar 2. Epub 2019 Mar 2.

Saint Louis University, Department of Psychiatry and Behavioral Neuroscience, St. Louis, MO, United States of America.

Background: Clozapine was the widely accepted gold standard treatment for treatment resistant psychotic symptoms. Clozapine has efficacy of about 50% and some responding patients have to discontinue it due to serious adverse effects. The search for novel agents to use for clozapine-non-responders continues. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.018DOI Listing
March 2019
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Associations between cannabis use and retinal vessel diameter in young adults.

Schizophr Res 2019 Mar 3. Epub 2019 Mar 3.

Department of Psychology, Arizona State University, P.O. Box 871104, Tempe, AZ 85287-1104, USA. Electronic address:

Cannabis appears to have vascular effects that may have implications for cerebrovascular function, but no studies have directly visualized the microvasculature in living cannabis users. The current study used retinal imaging, a tool taken from ophthalmology, to visualize the small retinal microvessels in cannabis users. We compared retinal arteriolar (small arteries) and venular (small veins) diameters in 55 frequent cannabis users and 51 comparison individuals with a mean age of 19. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.016DOI Listing
March 2019
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The challenge of well-being and quality of life: A meta-analysis of psychological interventions in schizophrenia.

Schizophr Res 2019 Mar 1. Epub 2019 Mar 1.

Department of Clinical Psychology, School of Psychology, Complutense University, Madrid, Spain.

Well-being is a critical outcome in the recovery from psychosis and the prevention of symptoms. Previous reviews of the effectiveness of psychological interventions have focused on psychotic symptoms and general psychopathology, not recognising well-being as an essential outcome. This study conducted a meta-analysis of the effects of psychological interventions on the well-being and quality of life (QoL) of people with schizophrenia and analysed some critical moderating factors. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.040DOI Listing

Longitudinal trajectory of early functional recovery in patients with first episode psychosis.

Schizophr Res 2019 Feb 27. Epub 2019 Feb 27.

Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA; Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, HMS, Boston, MA, USA.

Background: There is a large variability in the recovery trajectory and outcome of first episode of psychosis [FEP] patients. To date, individuals' outcome trajectories at early stage of illness and potential risk factors associated with a poor outcome trajectory are largely unknown. This study aims to apply three separate predictors (positive symptoms, negative symptoms, and soft neurological signs) to identify homogeneous function outcome trajectories in patients with FEP using objective data-driven methods, and to explore the potential risk /protective factors associated with each trajectory. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.003DOI Listing
February 2019
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Paranoid schizophrenia and methamphetamine-induced paranoia are both characterized by a similar LINE-1 partial methylation profile, which is more pronounced in paranoid schizophrenia.

Schizophr Res 2019 Feb 27. Epub 2019 Feb 27.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; IMPACT Strategic Research Center, Barwon Health, Geelong, Australia; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria. Electronic address:

Background: There is evidence that schizophrenia is a neuro-immune disorder. Genes linked to intragenic LINE-1 methylation show a strong association with immune-associated disorders including psychosis. The aim of this study was to examine LINE-1 methylation patterns in paranoid schizophrenia and methamphetamine-induced paranoia, a model for schizophrenia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09209964193007
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http://dx.doi.org/10.1016/j.schres.2019.02.015DOI Listing
February 2019
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Experiencing bird voices as auditory hallucinations - Phenomenological lessons from Phylogeny & Ethnography.

Schizophr Res 2019 Feb 25. Epub 2019 Feb 25.

Department of Psychiatry, NIMHANS, National Institute of Mental Health and Neuro Sciences (INI), Bangalore 560029, Karnataka, India.

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http://dx.doi.org/10.1016/j.schres.2019.02.009DOI Listing
February 2019

Gamma-band auditory steady-state response is associated with plasma levels of d-serine in schizophrenia: An exploratory study.

Schizophr Res 2019 Feb 25. Epub 2019 Feb 25.

Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; The International Research Center for Neurointelligence (WPI-IRCN) at The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.02.012DOI Listing
February 2019
3.923 Impact Factor

Positive and general psychopathology associated with specific gray matter reductions in inferior temporal regions in patients with schizophrenia.

Schizophr Res 2019 Feb 25. Epub 2019 Feb 25.

Department of Psychology, Georgia State University, Atlanta, GA, USA.

Schizophrenia is a complex disorder that affects perception, cognition, and emotion causing symptoms such as delusions, hallucinations, and suspiciousness. Schizophrenia is also associated with structural cortical abnormalities including lower gray matter (GM) concentration, GM volume, and cortical thickness relative to healthy control individuals. However, the association between GM measures and symptom dimensions in schizophrenia is still not well understood. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.010DOI Listing
February 2019
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P300 as an index of transition to psychosis and of remission: Data from a clinical high risk for psychosis study and review of literature.

Schizophr Res 2019 Feb 25. Epub 2019 Feb 25.

Harvard Medical School, Department of Psychiatry, Veterans Administration Medical Center, MA 02130, USA.

Auditory P300 oddball and novel components index working memory operations and salience processing, respectively, and are regarded as biomarkers of neurocognitive changes in both chronic and first-episode schizophrenia. Much less is known about whether P300 abnormalities exist in individuals at clinical high risk for psychosis (CHR) and if they are predictors of both transition to psychosis and remission from symptoms. One hundred and four CHR and 69 healthy control individuals (HC) completed P300 oddball paradigm, and 131 CHR and 69 HC subjects completed P300 novel paradigm. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.014DOI Listing
February 2019
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The reliability and clinical utility of ICD-11 schizoaffective disorder: A field trial.

Schizophr Res 2019 Feb 21. Epub 2019 Feb 21.

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA; Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland.

A major goal for the revision of the International Classification of Diseases and Related Health Problems, Tenth Edition (ICD-10) is to increase the clinical utility of the diagnostic system. Schizoaffective disorder has a history of poor diagnostic reliability due to the similarities and overlap in symptoms that it shares with other disorders, especially primary psychotic and mood disorders. The present study was part of the case-controlled field trials for ICD-11 and examines how the proposed changes for schizoaffective disorder may improve differential diagnosis and diagnostic accuracy. Read More

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http://dx.doi.org/10.1016/j.schres.2019.02.011DOI Listing
February 2019
2 Reads