136,144 results match your criteria Schizophrenia


[Correlation among serum levels of Irisin, insulin resistance and abdominal obesityin patients with first-episode schizophrenia].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):520-524

Department of Psychiatry, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.

To explore the possible role of Irisin in antipsychotic drug-induced insulin resistance and abdominal obesity in patients with schizophrenia and to provide a theoretical basis for the prevention of antipsychotic drug-induced obesity. Fifty-five patients with first-episode schizophrenia, from the First Affiliated Hospital of Zhengzhou University, between January 2016 and December 2017, were admitted as well as fifty healthy controls during the same period. Serum Irisin levels were measured by enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.009DOI Listing
February 2019

Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA.

Neuropsychopharmacology 2019 Feb 20. Epub 2019 Feb 20.

School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia.

Circular RNAs (circRNAs) are a covalently closed subclass of lncRNA molecules formed by back splicing of linear precursor RNA. These molecules are relatively stable and particularly abundant in the mammalian brain and therefore may participate in neural development and function. With the emergence of circRNAs activity in gene regulation, these molecules have been implicated in several biological processes, including synaptic plasticity, and we therefore suspect they may have a role in neurobehavioral disorders. Read More

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http://dx.doi.org/10.1038/s41386-019-0348-1DOI Listing
February 2019

Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; email:

There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of non-rapid eye movement (NREM) Stage 2 sleep that, in coordination with other NREM oscillations, mediate memory consolidation. In schizophrenia, the spindle deficit correlates with impaired sleep-dependent memory consolidation, positive symptoms, and abnormal thalamocortical connectivity. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-clinpsy-05
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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095754DOI Listing
February 2019
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Enhancing the Treatment of Patients With Schizophrenia Through Continuous Care.

J Clin Psychiatry 2019 Feb 19;80(1). Epub 2019 Feb 19.

University of North Carolina School of Medicine, Carrboro, North Carolina, USA.

Schizophrenia is a chronic disorder that can be effectively controlled but will likely require lifelong treatment. Unfortunately, most patients experience numerous relapses, ongoing symptoms, and impairment, often because of treatment interruptions. Continuous treatment is imperative to prevent relapse and the potentially devastating consequences that can follow a return of psychotic symptoms. Read More

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http://dx.doi.org/10.4088/JCP.al18010ah2cDOI Listing
February 2019

Can Adjunctive Pharmacotherapy Reduce Hospitalization in Schizophrenia?: Insights From Administrative Databases.

Authors:
Donald C Goff

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, New York.

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4318DOI Listing
February 2019

Comparative Effectiveness of Adjunctive Psychotropic Medications in Patients With Schizophrenia.

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, New York.

Importance: People with schizophrenia are commonly treated with psychotropic medications in addition to antipsychotics, but there is little evidence about the comparative effectiveness of these adjunctive treatment strategies.

Objective: To study the comparative real-world effectiveness of adjunctive psychotropic treatments for patients with schizophrenia.

Design, Setting, And Participants: This comparative effectiveness study used US national Medicaid data from January 1, 2001, to December 31, 2010, to examine the outcomes of initiating treatment with an antidepressant, a benzodiazepine, a mood stabilizer, or another antipsychotic among adult outpatients (aged 18-64 years) diagnosed with schizophrenia who were stably treated with a single antipsychotic. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4489DOI Listing
February 2019

Association of Antipsychotic Polypharmacy vs Monotherapy With Psychiatric Rehospitalization Among Adults With Schizophrenia.

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Importance: The effectiveness of antipsychotic polypharmacy in schizophrenia relapse prevention is controversial, and use of multiple agents is generally believed to impair physical well-being.

Objective: To study the association of specific antipsychotic combinations with psychiatric rehospitalization.

Design, Setting, And Participants: In this nationwide cohort study, the risk of psychiatric rehospitalization was used as a marker for relapse among 62 250 patients with schizophrenia during the use of 29 different antipsychotic monotherapy and polypharmacy types between January 1, 1996, and December 31, 2015, in a comprehensive, nationwide cohort in Finland. Read More

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http://archpsyc.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamapsychiatry.2018.4320DOI Listing
February 2019
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Mobile Phone and Wearable Sensor-Based mHealth Approaches for Psychiatric Disorders and Symptoms: Systematic Review.

JMIR Ment Health 2019 Feb 20;6(2):e9819. Epub 2019 Feb 20.

Ab.Acus srl, Milano, Italy.

Background: Mobile Therapeutic Attention for Patients with Treatment-Resistant Schizophrenia (m-RESIST) is an EU Horizon 2020-funded project aimed at designing and validating an innovative therapeutic program for treatment-resistant schizophrenia. The program exploits information from mobile phones and wearable sensors for behavioral tracking to support intervention administration.

Objective: To systematically review original studies on sensor-based mHealth apps aimed at uncovering associations between sensor data and symptoms of psychiatric disorders in order to support the m-RESIST approach to assess effectiveness of behavioral monitoring in therapy. Read More

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http://dx.doi.org/10.2196/mental.9819DOI Listing
February 2019

GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function.

Epigenomics 2019 Feb 20. Epub 2019 Feb 20.

Biomolecular Sciences Research Centre, Sheffield Hallam University, UK.

Aim: We investigated GRIN1 and GRIN2B promoter methylation in first-episode schizophrenia patients compared with siblings and controls, testing for correlations between DNA methylation, cognitive performance and clinical variables.

Materials & Methods: Blood-derived DNA from all groups underwent bisulfite conversion and pyrosequencing to determine methylation at CpG sites within the GRIN1 and GRIN2B promoters and results were compared with the measure of global methylation LINE-1.

Results: We found hypomethylation among all CpGs analyzed within GRIN2B promoter in patients and greater LINE-1 methylation in patients and siblings. Read More

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http://dx.doi.org/10.2217/epi-2018-0127DOI Listing
February 2019

Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping.

Neuroimage Clin 2019 Feb 13;22:101721. Epub 2019 Feb 13.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.

One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals with a 22q11. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101721DOI Listing
February 2019

Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.

Cell Rep 2019 Feb;26(8):2037-2051.e6

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address:

Altered excitatory/inhibitory (E/I) balance is implicated in neuropsychiatric and neurodevelopmental disorders, but the underlying genetic etiology remains poorly understood. Copy number variations in CYFIP1 are associated with autism, schizophrenia, and intellectual disability, but its role in regulating synaptic inhibition or E/I balance remains unclear. We show that CYFIP1, and the paralog CYFIP2, are enriched at inhibitory postsynaptic sites. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.092DOI Listing
February 2019

Dietary intake of people with severe mental illness: systematic review and meta-analysis.

Br J Psychiatry 2019 Feb 20:1-9. Epub 2019 Feb 20.

Associate Professor in Nutrition and Dietetics,School of Health Sciences and Priority Research Centre for Physical Activity and Nutrition,University of Newcastle,Australia.

Background: Severe mental illness (SMI) is thought to be associated with lower diet quality and adverse eating behaviours contributing towards physical health disparities. A rigorous review of the studies looking at dietary intake in psychotic disorders and bipolar disorder is lacking.AimsTo conduct a systematic, comprehensive evaluation of the published research on dietary intake in psychotic disorders and bipolar disorder. Read More

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http://dx.doi.org/10.1192/bjp.2019.20DOI Listing
February 2019

Using Twitter to assess attitudes to schizophrenia and psychosis.

BJPsych Bull 2019 Feb 20:1-9. Epub 2019 Feb 20.

Royal Edinburgh Hospital,University of Edinburgh,UK.

Aims and methodSchizophrenia is a psychotic disorder that is stereotypically stigmatised as untreatable and associated with violence. Several authorities have suggested that changing the name, for example to psychosis, would reduce such stigmatisation. We aimed to compare attitudes to schizophrenia and psychosis on Twitter to see if psychosis was associated with less negative attitudes. Read More

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http://dx.doi.org/10.1192/bjb.2018.115DOI Listing
February 2019

Memantine protects thalamocortical hyper-glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc.

Pharmacol Res Perspect 2019 Feb;7(1):e00457

Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu, Mie, Japan.

Deficiencies in N-methyl-d-aspartate (NMDA)/glutamate receptor (NMDAR) signaling have been considered central to the cognitive impairments of schizophrenia; however, an NMDAR antagonist memantine (MEM) improves cognitive impairments of Alzheimer's disease and schizophrenia. These mechanisms of paradoxical clinical effects of NMDAR antagonists remain unclear. To explore the mechanisms by which MK801 and MEM affect thalamocortical transmission, we determined interactions between local administrations of MK801, MEM, system xc (Sxc), and metabotropic glutamate receptors (mGluRs) on extracellular glutamate and GABA levels in the mediodorsal thalamic nucleus (MDTN) and medial prefrontal cortex (mPFC) using dual-probe microdialysis with ultra-high-pressure liquid chromatography. Read More

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http://dx.doi.org/10.1002/prp2.457DOI Listing
February 2019

Facebook Advertising for Disseminating Early Psychosis Education to the Chinese-Speaking General Public.

Authors:
Benjamin K P Woo

Health Equity 2019 13;3(1):19-21. Epub 2019 Feb 13.

Asian Pacific Health Corps, University of California, Los Angeles, Los Angeles, California.

To explore the role of Facebook advertisement in disseminating first-episode psychosis knowledge to the Chinese-speaking general public. A Facebook advertisement, linked to an external YouTube education video on first-episode psychosis, was displayed for 48 h. Metrics such as number of unique individuals reached, the number of engagements, the engagement rate (engagements/reaches), and the cost per post engagement were recorded. Read More

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http://dx.doi.org/10.1089/heq.2018.0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379044PMC
February 2019

"I Stopped Hearing Voices, Started to Stutter" - A Case of Clozapine-Induced Stuttering.

Indian J Psychol Med 2019 Jan-Feb;41(1):97-98

InSTAR Program, Schizophrenia and Metabolic Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_157_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337922PMC
February 2019

Expressed Emotion Research in India: A Narrative Review.

Indian J Psychol Med 2019 Jan-Feb;41(1):18-26

Department of Social Work, Linneaus University, Vaxjo, Sweden.

Background: Expressed emotion (EE) is detrimental to patients with schizophrenia, mood disorders, eating disorders and many other psychiatric and neurological disorders. However, majority of the EE literature is generated from the west, and the results of those studies may have limited application in Indian setting. Hence, we conducted this review with the main aim of understanding EE research in India and its potential role in the course and outcome of psychiatric disorders and other chronic illnesses. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_235_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337921PMC
February 2019

Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia.

Sci Rep 2019 Feb 19;9(1):2307. Epub 2019 Feb 19.

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia.

Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation is detectable in both brain and blood. We examined free mono-ubiquitin, ubiquitinated proteins, catalytic ubiquitination, and proteasome activities in frozen postmortem OFC tissue from 76 (38 schizophrenia, 38 control) matched individuals, as well as erythrocytes from 181 living participants, who comprised 30 individuals with recent onset schizophrenia (mean illness duration = 1 year), 63 individuals with 'treatment-resistant' schizophrenia (mean illness duration = 17 years), and 88 age-matched participants without major psychiatric illness. Ubiquitinated protein levels were elevated in postmortem OFC in schizophrenia compared to controls (p = <0. Read More

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http://dx.doi.org/10.1038/s41598-019-38490-1DOI Listing
February 2019

Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial.

Psychother Psychosom 2019 Feb 18:1-12. Epub 2019 Feb 18.

Community Psychiatry Service, Department of Psychiatry, University Hospital Centre, Lausanne, Switzerland.

Background: Negative symptoms are frequent in patients with schizophrenia and are associated with marked impairments in social functioning. The efficacy of drug-based treatments and psychological interventions on primary negative symptoms remains limited. The Positive Emotions Programme for Schizophrenia (PEPS) is designed to improve pleasure and motivation in schizophrenia patients by targeting emotion regulation and cognitive skills relevant to apathy and anhedonia. Read More

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https://www.karger.com/Article/FullText/496479
Publisher Site
http://dx.doi.org/10.1159/000496479DOI Listing
February 2019
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Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda.

BMJ Open 2019 Feb 19;9(2):e025469. Epub 2019 Feb 19.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Introduction: Schizophrenia and bipolar disorder account for a large proportion of the global burden of disease. Despite their enormous impact, little is known about their pathophysiology. Given the high heritability of schizophrenia and bipolar disorder, unbiased genetic studies offer the opportunity to gain insight into their neurobiology. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025469DOI Listing
February 2019

Clozapine Reduces Self-Injurious Behavior in a State Prison Population.

J Am Acad Psychiatry Law 2019 Feb 19. Epub 2019 Feb 19.

Dr. Zarzar is a Clinical Associate Professor, Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC. Ms. Catlett is Deputy Director, Health Services, Dr. O'Connell is Director of Mental Health, Dr. Harrelson is Chief of Psychiatry, Dr. Wilson is a family physician, Ms. Rashad is a staff psychologist, and Dr. Morris is Psychological Program Manager at North Carolina Department of Public Safety, Raleigh, NC. Dr. Williams is a Clinical Assistant Professor, Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC. Dr. Peebles is Medical Director, North Carolina Division of State Operated Healthcare Facilities, Raleigh, NC. Dr. Sheitman is a Professor, Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC.

Self-injurious behavior (SIB) is a common, disruptive, and costly occurrence in U.S. prisons. Read More

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http://dx.doi.org/10.29158/JAAPL.003818-19DOI Listing
February 2019

Changes in serum TNF-α, IL-18, and IL-6 concentrations in patients with chronic schizophrenia at admission and at discharge.

Compr Psychiatry 2019 Feb 8;90:82-87. Epub 2019 Feb 8.

The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), 36 Mingxin Road, Liwan District, Guangzhou, Guangdong Province 510370, China. Electronic address:

Objective: Schizophrenia is correlated with aberrant cytokine concentrations. The goal of our study was to detect the serum concentrations of tumor necrosis factor (TNF)-α, interleukin (IL)-18, and IL-6 concentrations in patients with chronic schizophrenia in the acute relapse state at admission and at discharge and to analyze the correlations between the three cytokine concentrations with psychosis symptoms.

Methods: Enzyme-linked immunosorbent assay (ELISA) was used to analyze serum concentrations of TNF-α, IL-18, and IL-6 in 68 patients with chronic schizophrenia at admission and at discharge and in 80 controls. Read More

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http://dx.doi.org/10.1016/j.comppsych.2019.01.003DOI Listing
February 2019

Effect of lurasidone vs olanzapine on neurotrophic biomarkers in unmedicated schizophrenia: A randomized controlled trial.

J Psychiatr Res 2019 Feb 12;112:1-6. Epub 2019 Feb 12.

Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. Electronic address:

Neurotrophic factors like Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin 3 (NT3) and Nerve Growth Factor (NGF), play a role in neuroplasticity and neurogenesis contributing to the pathogenesis of schizophrenia. The objective of the present study was to investigate and compare the effect of olanzapine and lurasidone on the change in serum neurotrophins in patients with schizophrenia. The present study was a randomized, open-label, active-controlled, parallel design clinical trial. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.007DOI Listing
February 2019

Neuroimaging auditory verbal hallucinations in schizophrenia patient and healthy populations.

Psychol Med 2019 Feb 20:1-10. Epub 2019 Feb 20.

Department of Psychiatry,Brigham and Women's Hospital, Harvard Medical School,Boston, Massachusetts,USA.

Background: Auditory verbal hallucinations (AVH) are a cardinal feature of schizophrenia, but they can also appear in otherwise healthy individuals. Imaging studies implicate language networks in the generation of AVH; however, it remains unclear if alterations reflect biologic substrates of AVH, irrespective of diagnostic status, age, or illness-related factors. We applied multimodal imaging to identify AVH-specific pathology, evidenced by overlapping gray or white matter deficits between schizophrenia patients and healthy voice-hearers. Read More

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http://dx.doi.org/10.1017/S0033291719000205DOI Listing
February 2019

A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder.

BMC Psychiatry 2019 Feb 19;19(1):73. Epub 2019 Feb 19.

Psychopharmacology Unit, Clinical pharmacology and toxicology division, Acute Medicine Department, Geneva University Hospital, Geneva, Switzerland.

Background: Rebound cholinergic syndrome is a rare, but well known unwanted phenomenon occurring after abrupt clozapine discontinuation. There have been previous reported cases of cholinergic rebound in the literature; however, these reports described cholinergic rebound following cessation of high doses of clozapine in patients diagnosed with schizophrenia. Here, we report a case of rebound cholinergic syndrome and catatonia in a male patient three days after abrupt discontinuation of 50 mg of clozapine prescribed for type I bipolar affective disorder. Read More

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http://dx.doi.org/10.1186/s12888-019-2055-1DOI Listing
February 2019

hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia.

Biomark Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, The Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, People's Republic of China.

Aim: To assess whether expression of circular RNAs (circRNAs) in peripheral blood mononuclear cells can serve as a biomarker for diagnosis and/or therapeutic response in people living with schizophrenia (SZ).

Materials & Methods: Differentially expressed circRNAs were screened via microarray in nine individuals living with SZ and nine healthy controls, then quantified using real-time quantitative reverse transcription PCR in SZ (n = 102) and healthy control (n = 103) groups. CircRNAs were re-assessed twice in 30 randomly selected individuals living with SZ after 4- and 8-week antipsychotic treatments. Read More

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http://dx.doi.org/10.2217/bmm-2018-0447DOI Listing
February 2019

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses.

Diseases 2019 Feb 13;7(1). Epub 2019 Feb 13.

Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.

Psychiatric illnesses may be qualified to the cellular impairments of the function for survival or death in neurons, which may consequently appear as abnormalities in the neuroplasticity. The molecular mechanism has not been well understood, however, it seems that PI3K, AKT, GSK3, and their downstream molecules have crucial roles in the pathogenesis. Through transducing cell surviving signal, the PI3K/AKT/GSK3 pathway may organize an intracellular central network for the action of the synaptic neuroplasticity. Read More

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http://dx.doi.org/10.3390/diseases7010022DOI Listing
February 2019

Sexual dysfunction and hyperprolactinemia in schizophrenia before and after six weeks of D receptor blockade - An exploratory study.

Psychiatry Res 2019 Feb 8;274:58-65. Epub 2019 Feb 8.

Center for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Clinical Medicine, Denmark.

Sexual side-effects along with antipsychotic treatment may be linked to hyperprolactinemia and dopamine D receptor blockade. High prevalence of sexual dysfunction in un-medicated patients challenges the notion of sexual dysfunction as merely a side-effect of antipsychotic medication. Sexual dysfunction was assessed in fifty-six initially antipsychotic-naïve patients with schizophrenia using the UKU (Udvalget for Kliniske Undersøgelser) questionnaire. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.017DOI Listing
February 2019

The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons.

Neurosci Lett 2019 Feb 16. Epub 2019 Feb 16.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, 60611 IL, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, 60611 IL, USA; Northwestern University Center for Autism and Neurodevelopment, Chicago IL 60611, USA. Electronic address:

GABAergic interneurons are emerging as prominent substrates in the pathophysiology of multiple neurodevelopmental disorders, including autism spectrum disorders, schizophrenia, intellectual disability, and epilepsy. Interneuron excitatory activity is influenced by 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid receptors (AMPARs), which in turn affects excitatory transmission in the central nervous system. Yet how dysregulation of interneuronal AMPARs distinctly contributes to the molecular underpinning of neurobiological disease is drastically underexplored. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.025DOI Listing
February 2019

Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene.

Pharmacol Biochem Behav 2019 Feb 16. Epub 2019 Feb 16.

Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address:

In humans, mutations in the Disrupted-in-schizophrenia 1 (DISC1) gene have been related to psychiatric disorders, including symptoms of abnormal cognitive and emotional behaviors. In our previous studies, overexpression of the human DISC1 gene in rats resulted in schizophrenia-like phenotypes showing deficits in motor learning, impaired cognitive function and dysfunctions of the dopamine system. Here we asked, whether the DISC1 overexpression affects locomotor activity in the open field (OF), anxiety in the elevated plus-maze (EPM), depression-related behavior in the forced swim test (FST), and attention-like/short-term working-memory in the spontaneous alternation behavior (SAB) in the T-maze in transgenic DISC1 (tgDISC1) rats and littermate controls (WT). Read More

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http://dx.doi.org/10.1016/j.pbb.2019.02.005DOI Listing
February 2019

Analysis of 15q11.2 CNVs in an Indian population with schizophrenia.

Ann Hum Genet 2019 Feb 19. Epub 2019 Feb 19.

Department of Biological Sciences, BITS Pilani, Hyderabad Campus, Hyderabad, 500078, India.

Copy number variants (CNVs) of 15q11.2 yielded conflicting reports on their association with schizophrenia (SZ), indicating the need for replication studies. Because there are no 15q11. Read More

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http://dx.doi.org/10.1111/ahg.12300DOI Listing
February 2019

A Brief History of Immunological Research into Psychosis and Pathways for Immune Influence of the Brain.

Authors:
Norbert Müller

Curr Top Behav Neurosci 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry and Psychotherapy, Ludwig Maximilian University and Marion von Tessin Memory Center, Munich, Germany.

Infection and inflammation resulting from a malfunctioning of the immune system have been discussed as pathological factors in psychosis for more than 130 years. The first immune-modulating therapeutic approaches for psychosis were developed more than 100 years ago, but the breakthrough of antipsychotic treatment in the 1950s shifted the emphasis of research to catecholaminergic neurotransmission. In the 1990s, however, the unsatisfactory therapeutic effects of antipsychotics, and the fact that the pathological mechanisms of psychosis were still unknown, reignited the scientific interest in other topics, including inflammation. Read More

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http://dx.doi.org/10.1007/7854_2018_82DOI Listing
February 2019

[Cognitive and neural mechanisms underlying working memory].

Authors:
Yixuan Ku

Sheng Li Xue Bao 2019 Feb;71(1):173-185

School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China.

Working memory (WM) refers to the process of temporally maintaining and manipulating input information. WM is the global workspace of cognitive functions, however, with severely restricted capacity and precision. Previous cognitive and computational models discussed the methods of calculating capacity and precision of WM and the reason why they are so limited. Read More

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February 2019

[The Figurative Language Test: An instrument for the assessment of concretism in schizophrenic patients].

Vertex 2018 May;XXIX(139):184-191

Servicio de Psiquiatría (31 B), Hospital Borda. Escuela de Posgrado de la Facultad de Medicina de la Universidad del Salvador.

Background: Concretism is a recognized formal thought disorder of schizophrenia, which has been studied clinically by proverb interpretation. To avoid the shortcomings of oral proverbs, there have been developed tests with multiple choice format, which have the advantage of avoiding the disparity of criteria and simplifying its application. In the absence of an equivalent test in Spanish, it is of interest to elaborate a test of this type to be used for clinical and research purposes. Read More

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[Thrombodynamic parameters of hypercoagulation of blood in children with childhood autism and schizophrenia].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):59-63

Mental Health Research Center of Russian Academy of Sciences, Moscow, Russia.

Aim: To detect blood plasma coagulability in children with mental diseases using a thrombodynamics test.

Material And Methods: The study included two groups of children. Group 1 included 11 patients with infantile psychosis in autism (F84. Read More

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http://dx.doi.org/10.17116/jnevro201911901159DOI Listing
January 2019

[The use of eeg discriminant analysis in the diagnosis of schizophrenia].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):44-50

Pirogov Russian National Research Medical University, Moscow, Russia.

Aim: There have been no criteria found so far to quantify the wide range of EEG spectral and coherent indicators, which would allow discrimination between schizophrenia disorders and healthy human states. The goal of this research is to find objective EEG-based schizophrenia criteria through a discriminant analysis and to obtain a linear discriminant function (LDF) with sensitivity and specificity of at least 85%.

Material And Methods: The study covered 83 schizophrenia patients and 116 healthy individuals, with similar major characteristics. Read More

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http://dx.doi.org/10.17116/jnevro201911901144DOI Listing
January 2019

[Follow-up recommendations for the late preterm infant].

An Pediatr (Barc) 2019 Feb 15. Epub 2019 Feb 15.

Grupo SEN34-36/ACUNA, Sociedad Española de Neonatología, España; Servicio de Pediatría-Neonatología, SCIAS, Hospital Barcelona, Barcelona, España.

The population of late preterm infants (PT), those born between 34+0 and 36+6 weeks of gestation, accounts for 70-74% of all premature infants, and is not specifically included in most of the follow-up protocols for preterm infants. For many years, PTs have been handled as if they were term newborns, which has led to a limited knowledge of their outcome in the medium and long term. Their neonatal morbidity is associated with a higher incidence of postnatal complications, with an increased rate of hospital re-admissions due to malnutrition, hyperbilirubinaemia, and respiratory problems, when compared to term infants. Read More

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http://dx.doi.org/10.1016/j.anpedi.2019.01.008DOI Listing
February 2019

The Early Psychosis Screener for Internet (EPSI)-SR: Predicting 12 month psychotic conversion using machine learning.

Schizophr Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0810, USA. Electronic address:

Introduction: A faster and more accurate self-report screener for early psychosis is needed to promote early identification and intervention.

Methods: Self-report Likert-scale survey items were administered to individuals being screened with the Structured Interview for Psychosis-risk Syndromes (SIPS) and followed at eight early psychosis clinics. An a priori analytic plan included Spectral Clustering Analysis to reduce the item pool, followed by development of Support Vector Machine (SVM) classifiers. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.015DOI Listing
February 2019
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Should antipsychotic medications for schizophrenia be given for a lifetime? Replication of a naturalistic, long-term, follow-up study of antipsychotic treatment.

CNS Spectr 2019 Feb 19:1-7. Epub 2019 Feb 19.

4College of Medicine,University of Illinois,Chicago,Illinois,USA.

Objective: Because ethically and practically a randomized control trial of antipsychotics will never be done, we recently conducted and reported a 8- to 50-year, naturalistic follow-up from an academic clinic of patients with chronic schizophrenia on antipsychotic medication. We found that better medication adherence was a statistically significant predictor of better long-term global outcome and life satisfaction. Because there were important limitations on our findings, we now in this communication, using similar methodology, detail outcomes for a very different sample-inner city patients with chronic schizophrenia with a long past history of antipsychotic treatment, who were enrolled in clinical trials for new medications for schizophrenia. Read More

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http://dx.doi.org/10.1017/S109285291800144XDOI Listing
February 2019

Molecular Mechanisms of Transcription Factor 4 in Pitt Hopkins Syndrome.

Curr Genet Med Rep 2017 Mar 11;5(1):1-7. Epub 2017 Feb 11.

Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.

Purpose Of Review: Pitt Hopkins syndrome (PTHS) is a rare neurodevelopmental disorder that results from mutations of the clinically pleiotropic Transcription Factor 4 (TCF4) gene. Mutations in the genomic locus of TCF4 on chromosome 18 have been linked to multiple disorders including 18q syndrome, schizophrenia, Fuch's corneal dystrophy, and sclerosing cholangitis. For PTHS, TCF4 mutation or deletion leads to the production of a dominant negative TCF4 protein and/or haploinsufficiency that results in abnormal brain development. Read More

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http://link.springer.com/10.1007/s40142-017-0110-0
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http://dx.doi.org/10.1007/s40142-017-0110-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376960PMC
March 2017
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Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls.

J Psychiatr Res 2019 Feb 8;111:169-185. Epub 2019 Feb 8.

Brain Research Center, Ankara University, Ankara, Turkey. Electronic address:

Compared to the general population, individuals diagnosed with Schizophrenia (SCZ) experience a higher frequency and an earlier onset of chronic medical disorders, resulting in a reduction in life expectancy by an average of 15-25 years. Recently, it has been hypothesized that SCZ is a syndrome of accelerated aging. Childhood adversity was also associated with the pathogenesis and course of SCZ. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.022DOI Listing
February 2019

Trends in concept and nosology of autism spectrum disorder: A review.

Asian J Psychiatr 2019 Feb 10;40:92-99. Epub 2019 Feb 10.

Department of Psychiatry and National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India.

Autism Spectrum Disorder is a neurodevelopmental disorder characterized by persistent deficits in social communication, social interaction and restricted, repetitive patterns of behavior, interests or activities. The concept of autism has changed since its inception, from childhood schizophrenia to neuro-variation. These changes in concept have been accompanied by changes in the diagnostic threshold through which the 'case' of autism is identified. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.01.021DOI Listing
February 2019

Antipsychotic-minocycline-acetylcysteine combination for positive, cognitive, and negative symptoms of schizophrenia.

Asian J Psychiatr 2019 Feb 12;40:100-102. Epub 2019 Feb 12.

Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, 2300 I St NW, 20037, Washington, DC, USA. Electronic address:

Preclinical evidence shows that the minocycline and N-acetylcysteine (NAC) combination synergistically improved cognition. Meta-analyses of randomized controlled trials (RCTs) with minocycline and NAC have shown some efficacy signal for positive, cognitive, and negative symptoms of schizophrenia. Hence, the combination may be more effective than either medication alone. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.007DOI Listing
February 2019

A meta-analysis and systematic review of Memory Specificity Training (MeST) in the treatment of emotional disorders.

Behav Res Ther 2019 Feb 2;116:36-51. Epub 2019 Feb 2.

Centre for Learning Psychology and Experimental Psychopathology, University of Leuven, Leuven, Belgium.

The tendency to recall events from one's past in a non-specific and overgeneral way has been found to predict the onset and severity of a range of emotional disorders. Memory Specificity Training (MeST) was devised a decade ago in order to target and modify this tendency so as to reduce the symptoms of emotional disorder or to reduce the risk that such disorders might emerge over time. We present a meta-analytical review of research into the effects of MeST on autobiographical memory specificity in the context of emotional disorders (k = 13). Read More

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http://dx.doi.org/10.1016/j.brat.2019.02.001DOI Listing
February 2019

Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating.

J Ethnopharmacol 2019 Feb 15;235:320-328. Epub 2019 Feb 15.

Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Germany; Center of Behavioral Brain Sciences, Otto-von-Guericke University Magdeburg, Germany. Electronic address:

ETHNOPHARMACOLOGICAL RELEVANCE: The plant arctic root (Rhodiola rosea, L.) is growing in northern regions of Europe, Asia and North America. Extracts of R. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.031DOI Listing
February 2019

An examination of the moderating effects of neurophysiology on treatment outcomes from cognitive training in schizophrenia-spectrum disorders.

Int J Psychophysiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychology, Queen's University, Kingston, Ontario, Canada; Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Electronic address:

Background: Impairments in neurocognition and community functioning are core features of schizophrenia and cognitive training techniques have been developed with the aim of improving these impairments. While cognitive training has produced reliable improvements in neurocognition and functioning, little is known about factors that moderate treatment response. Electroencephalographic (EEG) measures provide a neurophysiological indicator of cognitive functions that may moderate treatment outcomes from cognitive training. Read More

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http://dx.doi.org/10.1016/j.ijpsycho.2019.02.004DOI Listing
February 2019

Heritability of Cerebral Blood Flow and the Correlation to Schizophrenia Spectrum Disorders: A Pseudo-continuous Arterial Spin Labeling Twin Study.

Schizophr Bull 2019 Feb 18. Epub 2019 Feb 18.

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Centre Glostrup, University of Copenhagen, Copenhagen, Denmark.

Whether aberrant cerebral blood flow (CBF) in schizophrenia is affected by genetic influences, and consequently a potential marker for genetic susceptibility, is unknown. Our aims were to determine the heritability of CBF in thalamic, frontal, and striatal areas, and to ascertain if associations with disease were under genetic influence. Monozygotic (MZ) twin pairs concordant (n = 2) or discordant (n = 20) for schizophrenia spectrum disorders (ICD-10 F2x. Read More

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http://dx.doi.org/10.1093/schbul/sbz007DOI Listing
February 2019

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice.

Sci Adv 2019 Feb 6;5(2):eaau8317. Epub 2019 Feb 6.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs). Read More

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http://dx.doi.org/10.1126/sciadv.aau8317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365110PMC
February 2019

A novel approach to cardiovascular disturbances in patients with schizophrenia spectrum disorders treated with long-acting injectable medication.

Neuropsychiatr Dis Treat 2019 25;15:349-355. Epub 2019 Jan 25.

Medical Semiology II, Department of Internal Medicine I, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.

Purpose: This research article assesses the cardiovascular impact of long-term injectable antipsychotic therapy on patients diagnosed with schizophrenia spectrum disorders. In our study, we attempted to quantify the potential causes of cardiovascular damage, assess cardiovascular parameters, and correlate them with the time elapsed from the onset of the psychosis until the initiation of injectable antipsychotic therapy, as well as the duration of long-acting therapy, and finally, to compare two of the most utilized long-acting injectable (LAI) medications (olanzapine vs risperidone).

Patients And Methods: This cross-sectional study recruited 64 patients of 2 outpatient clinics undergoing treatment with LAI antipsychotics for schizophrenic spectrum disorder. Read More

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http://dx.doi.org/10.2147/NDT.S186892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354682PMC
January 2019

Cognition and physical functioning in patients with schizophrenia: any role for vitamin D?

Nutr Neurosci 2019 Feb 17:1-9. Epub 2019 Feb 17.

a Psychiatric Hospital of the Cross , Jal Eddib , Lebanon.

Aim: The study's objective was to evaluate the relationship between vitamin D (VD) levels and cognitive performance in patients with schizophrenia.

Methods: A cross-sectional study, conducted between March and July 2016, recruited 196 patients with schizophrenia. The Brief Cognitive Rating Scale (BCRS) and the Morningside Rehabilitation Status Scale (MRSS) were used to measure the severity of cognitive impairment and the level of general functioning in psychiatric patients. Read More

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http://dx.doi.org/10.1080/1028415X.2019.1580830DOI Listing
February 2019