149,215 results match your criteria Schizophrenia

White matter microstructure alterations in cortico-striatal networks are associated with parkinsonism in schizophrenia spectrum disorders.

Eur Neuropsychopharmacol 2021 May 10;50:64-74. Epub 2021 May 10.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:

The specific role of white matter (WM) microstructure in parkinsonism among patients with schizophrenia spectrum disorders (SSD) is largely unknown. To determine whether topographical alterations of WM microstructure contribute to parkinsonism in SSD patients, we examined healthy controls (HC, n=16) and SSD patients with and without parkinsonism, as defined by Simpson-Angus Scale total score of ≥4 (SSD-P, n=33) or <4 (SSD-nonP, n=62). We used whole brain tract-based spatial statistics (TBSS), tractometry (along tract statistics using TractSeg) and graph analytics (clustering coefficient (CCO), local betweenness centrality (BC)) to provide a framework of specific WM microstructural changes underlying parkinsonism in SSD. Read More

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Convergent validity of the Chinese version of the Multidimensional Schizotypy Scale.

Asian J Psychiatr 2021 May 9;61:102671. Epub 2021 May 9.

Neuropsychology and Applied Cognitive Neuroscience Lab, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

Schizotypy is the latent personality reflecting the liability to schizophrenia. The Multidimensional Schizotypy Scale (MSS) is a newly developed questionnaire to measure the levels of schizotypy. The Chinese version of MSS has been developed and previous findings supported its structure validity. Read More

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Event-related potentials associated to N-back test performance in schizophrenia.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 10:110347. Epub 2021 May 10.

Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005 Valladolid, Spain; Psychiatry Service, Clinical University Hospital Valladolid, Spain. Electronic address:

Mapping of Event-Related Potentials (ERP) associated with auditory and visual odd-ball paradigms has shown consistent differences between healthy controls and schizophrenia patients. It may be hypothesized that higher task attentional/cognitive demand will result in larger differences in these paradigms, which may help understanding the substrates of cognitive deficits in this syndrome. To this aim, we performed an EEG study comparing the effects of increasing the attentional/cognitive load of an auditory N-back task on the Event-Related Potential in 50 subjects with schizophrenia (11 first episodes) and 35 healthy controls. Read More

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Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 10:110348. Epub 2021 May 10.

Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, SP, Brazil. Electronic address:

Schizophrenia is a severe mental disorder with complex etiopathogenesis. Based on its neurodevelopmental features, an animal model induced by "two-hit" based on perinatal immune activation followed by peripubertal unpredictable stress was proposed. Sex influences the immune response, and concerning schizophrenia, it impacts the age of onset and symptoms severity. Read More

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Editorial for "Altered Complexity of Spontaneous Brain Activity in Schizophrenia and Bipolar Disorder Patients".

Haifeng Wang

J Magn Reson Imaging 2021 May 13. Epub 2021 May 13.

Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen, Guangdong, China.

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Maternal Hypertensive Pregnancy Disorders and Mental and Behavioral Disorders in the Offspring: a Review.

Curr Hypertens Rep 2021 May 13;23(5):30. Epub 2021 May 13.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 9, FI-00014 University of Helsinki, Helsinki, Finland.

Purpose Of Review: We review here recent original research and meta-analytic evidence on the associations of maternal hypertensive pregnancy disorders and mental and behavioral disorders in the offspring.

Recent Findings: Seven meta-analyses and 11 of 16 original research studies published since 2015 showed significant associations between maternal hypertensive pregnancy disorders and offspring mental and behavioral disorders. Evidence was most consistent in meta-analyses and high-quality cohort studies. Read More

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Discovery of rare variants implicated in schizophrenia using next-generation sequencing.

J Transl Genet Genom 2019 20;3(1):1-20. Epub 2019 Jan 20.

Department of Biology, Howard University, Washington, DC 20059, USA.

Schizophrenia is a highly heritable psychiatric disorder that affects 1% of the population. Genome-wide association studies have identified common variants in candidate genes associated with schizophrenia, but the genetics mechanisms of this disorder have not yet been elucidated. The discovery of rare genetic variants that contribute to schizophrenia symptoms promises to help explain the missing heritability of the disease. Read More

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January 2019

Ketamine disrupts naturalistic coding of working memory in primate lateral prefrontal cortex networks.

Mol Psychiatry 2021 May 12. Epub 2021 May 12.

Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada.

Ketamine is a dissociative anesthetic drug, which has more recently emerged as a rapid-acting antidepressant. When acutely administered at subanesthetic doses, ketamine causes cognitive deficits like those observed in patients with schizophrenia, including impaired working memory. Although these effects have been linked to ketamine's action as an N-methyl-D-aspartate receptor antagonist, it is unclear how synaptic alterations translate into changes in brain microcircuit function that ultimately influence cognition. Read More

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Schizophrenia-associated LRRTM1 regulates cognitive behavior through controlling synaptic function in the mediodorsal thalamus.

Mol Psychiatry 2021 May 12. Epub 2021 May 12.

Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, MB, Canada.

Reduced activity of the mediodorsal thalamus (MD) and abnormal functional connectivity of the MD with the prefrontal cortex (PFC) cause cognitive deficits in schizophrenia. However, the molecular basis of MD hypofunction in schizophrenia is not known. Here, we identified leucine-rich-repeat transmembrane neuronal protein 1 (LRRTM1), a postsynaptic cell-adhesion molecule, as a key regulator of excitatory synaptic function and excitation-inhibition balance in the MD. Read More

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Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study.

Mol Psychiatry 2021 May 12. Epub 2021 May 12.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.

Dopaminergic dysregulation is one of the leading hypotheses for the pathoetiology underlying psychotic disorders such as schizophrenia. Molecular imaging studies have shown increased striatal dopamine synthesis capacity (DSC) in schizophrenia and people in the prodrome of psychosis. However, it is unclear if genetic risk for psychosis is associated with altered DSC. Read More

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Dynamic functional connectivity and its anatomical substrate reveal treatment outcome in first-episode drug-naïve schizophrenia.

Transl Psychiatry 2021 May 12;11(1):282. Epub 2021 May 12.

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Zhejiang, China.

Convergent evidence has suggested a significant effect of antipsychotic exposure on brain structure and function in patients with schizophrenia, yet the characteristics of favorable treatment outcome remains largely unknown. In this work, we aimed to examine how large-scale brain networks are modulated by antipsychotic treatment, and whether the longitudinal changes could track the improvements of psychopathologic scores. Thirty-four patients with first-episode drug-naïve schizophrenia and 28 matched healthy controls were recruited at baseline from Shanghai Mental Health Center. Read More

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Clinical, Neuroimmunologic, and CSF Investigations in First Episode Psychosis.

Neurology 2021 May 12. Epub 2021 May 12.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain;

Objectives: To report the neuropsychiatric features and frequency of N-methyl-d-aspartate receptor (NMDAR) and other neuronal IgG antibodies in patients with first episode psychosis (FEP), and assess the performance of reported warning signs and criteria for autoimmune psychosis (AP).

Methods: Prospective observational study of patients with FEP assessed for neuropsychiatric symptoms, serum and CSF neuronal antibodies (brain immunohistochemistry, cell-based assays, live neurons), and warning signs and criteria of AP. Previous autoimmune FEP series were reviewed. Read More

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Pharmacotherapy management of schizophrenia for family physicians.

Can Fam Physician 2021 May;67(5):350-354

Assistant Professor in the College of Pharmacy and Nutrition at the University of Saskatchewan and a clinical psychiatric pharmacist in Saskatoon.

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Formal thought disorder in patients with first-episode schizophrenia: Results of a one-year follow-up study.

Psychiatry Res 2021 Apr 29;301:113972. Epub 2021 Apr 29.

Department of Psychiatry, Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Formal thought disorder (FTD) refers to abnormal speech patterns that can be characterized by deficiencies in thought organization and direction. The present study aimed to assess the factor structure of FTD and to examine its relationship with cognition and clinical features at first admission in patients with first-episode schizophrenia. We also examined the course of FTD during the twelve months after first admission. Read More

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Quality versus quantity: Determining real-world social functioning deficits in schizophrenia.

Psychiatry Res 2021 May 1;301:113980. Epub 2021 May 1.

Department of Psychology, Indiana University - Purdue University Indianapolis, LD 124, 402N Blackford St, Indianapolis, IN 46202, United States.

Social dysfunction is a hallmark of schizophrenia that is associated with emotional disturbances. Researchers have employed ecological momentary assessment (EMA) to measure social and emotional functioning in people with schizophrenia. Yet, few studies have evaluated quality of real-world social interactions, and it is unclear how interactions impact emotional experiences in this population. Read More

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Meta-analytic exploration of the joint factors of the Brief Psychiatric Rating Scale - Expanded (BPRS-E) and the positive and negative symptoms scales (PANSS).

J Psychiatr Res 2021 Apr 23;138:519-527. Epub 2021 Apr 23.

Department of Human Sciences, Lumsa University, Rome, Italy.

Previous meta-analyses of the BPRS-E and PANSS were combined to analyze the joint factors across 77 factor analyses from 68 studies of 32,896 individuals. The BPRS-E and PANSS share the 18 original BPRS items and each has additional unique items (6 BPRS-E and 12 PANSS). Based on the combined data across the BPRS-E and PANSS four separate sets of factor analyses were conducted using sample weighting (weighted and unweighted) and matrix type (similarity coefficients and reproduced correlations). Read More

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Better Evidence for Pharmacological Maintenance Treatment in Nonaffective Psychoses: Implications for Relapse Prevention.

William G Honer

Am J Psychiatry 2021 May;178(5):369-371

Department of Psychiatry, University of British Columbia, and British Columbia Mental Health and Substance Use Services Research Institute, Vancouver, Canada.

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Hippocampal atrophy is associated with psychotic symptom severity following traumatic brain injury.

Brain Commun 2021 9;3(2):fcab026. Epub 2021 Mar 9.

Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.

Psychosis is a rare, but particularly serious sequela of traumatic brain injury. However, little is known as to the neurobiological processes that may contribute to its onset. Early evidence suggests that psychotic symptom development after traumatic brain injury may co-occur with hippocampal degeneration, invoking the possibility of a relationship. Read More

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GRK3 deficiency elicits brain immune activation and psychosis.

Mol Psychiatry 2021 May 12. Epub 2021 May 12.

Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

The G protein-coupled receptor kinase (GRK) family member protein GRK3 has been linked to the pathophysiology of schizophrenia and bipolar disorder. Expression, as well as protein levels, of GRK3 are reduced in post-mortem prefrontal cortex of schizophrenia subjects. Here, we investigate functional behavior and neurotransmission related to immune activation and psychosis using mice lacking functional Grk3 and utilizing a variety of methods, including behavioral, biochemical, electrophysiological, molecular, and imaging methods. Read More

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Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats.

Acta Pharmacol Sin 2021 May 11. Epub 2021 May 11.

College of Pharmaceutical Sciences, Medical Research Institute, Southwest University, Chongqing, 400715, China.

Brexpiprazole (Bre) is a new multi-target antipsychotic drug (APD) approved by the US FDA in 2015, and shows good therapeutic potential. But it lacks assessments on the metabolic side effects, which obstructs the treatment of schizophrenia. Glucagon-like peptide 1 (GLP1), an incretin associated with insulin action and metabolism, is involved in the metabolic syndrome (MS) caused by most APDs. Read More

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Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder.

Sci Rep 2021 May 11;11(1):9992. Epub 2021 May 11.

Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Chemin du Petit-Bel-Air, 1225, Chêne-Bourg, Switzerland.

Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD). The relationship to different psychopathological dimensions within these disorders however remains to be elucidated. We thus investigated potential group differences of tryptophan, kynurenine, kynurenic acid, 3-hydroxy kynurenine and quinolinic acid in the plasma of 19 healthy controls (HC), 45 patients with SZ and 43 patients with MDD and correlated plasma proteins with the "motivation and pleasure" dimension and cognition. Read More

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Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation.

Indian J Pharmacol 2021 Jan-Feb;53(1):2-5

Department of Clinical Pharmacy and Pharm. D, Vaagdevi College of Pharmacy, Kakatiya University, MGM Hospital, Warangal, Telangana, India.

Aim: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically.

Subjects And Methods: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-performance liquid chromatography and brief psychiatry rating scale was used to determine disease progression. Read More

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TPN672: A Novel Serotonin-Dopamine Activity Modulator for the Treatment of Schizophrenia.

J Pharmacol Exp Ther 2021 May 11. Epub 2021 May 11.

China Pharmaceutical University, China

TPN672,7-(2-(4-(benzothiophen-4-yl) piperazin-1-yl) ethyl) quinolin-2(1H)-one maleate, is a novel antipsychotic candidate with high affinity for serotonin and dopamine receptors, that is currently in clinical trial for the treatment of psychiatric disorders. In vitro binding study showed that TPN672 exhibited extremely high affinity for serotonin 1A receptor (5-HTR) (Ki = 0.23 nM) and 5-HTR (Ki = 2. Read More

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Commentary: the ethical challenges of machine learning in psychiatry: a focus on data, diagnosis, and treatment.

Daniel S Barron

Psychol Med 2021 May 12:1-3. Epub 2021 May 12.

Department of Psychiatry, Yale University, New Haven, CT, USA.

The clinical interview is the psychiatrist's data gathering procedure. However, the clinical interview is not a defined entity in the way that 'vitals' are defined as measurements of blood pressure, heart rate, respiration rate, temperature, and oxygen saturation. There are as many ways to approach a clinical interview as there are psychiatrists; and trainees can learn as many ways of performing and formulating the clinical interview as there are instructors (Nestler, 1990). Read More

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A sequence analysis of hospitalization patterns and service utilization in patients with major psychiatric disorders in China.

BMC Psychiatry 2021 May 11;21(1):245. Epub 2021 May 11.

Department of Psychiatry and Behavioral Sciences, Emory University, 12 Executive Park Drive NE, Suite 300, Atlanta, GA, USA; Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA, USA.

Background: Understanding the long-term inpatient service cost and utilization of psychiatric patients may provide insight into service demand for these patients and guide the design of targeted mental health programs. This study assesses 3-year hospitalization patterns and quantifies service utilization intensity of psychiatric patients in Beijing, China.

Methods: We identified patients admitted for one of three major psychiatric disorders (schizophrenia, bipolar and depressive disorders) between January 1 and December 31, 2013 in Beijing, China. Read More

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A Phenomenological Exploration of the Voices Reported by Borderline Personality and Schizophrenia Patients.

Psychopathology 2021 May 11:1-9. Epub 2021 May 11.

Complex Needs Service, Oxford, United Kingdom.

Introduction: Over time, there have been different views regarding the verbal auditory hallucinations (VAHs) reported by borderline personality disorder (BPD) and schizophrenia patients. More recently, their similarity has been emphasized, a view that undoubtedly has significant implications in terms of differential diagnosis and management. To explore this important issue, we undertook a detailed phenomenological assessment of persistent VAH reported by BPD and schizophrenia DSM-IV participants. Read More

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Impact of cannabis use on outcomes of patients admitted to an involuntary psychiatric unit: A retrospective cohort study.

J Psychiatr Res 2021 Apr 30;138:507-513. Epub 2021 Apr 30.

Department of Psychiatry, CHU Nimes, Univ Montpellier, Nimes, France; INSERM et Université de Montpellier, Montpellier, France; CIBERSAM, Spain. Electronic address:

Introduction: Cannabis is associated with an increased risk of mental disorders, including the onset or adverse evolution of schizophrenia, bipolar disorder and depression. The aim of our study was to examine how cannabis use influences length of stay and readmissions in a unit of involuntary care.

Method: All patients admitted to one secure adult psychiatry unit in France in 2016 were included (n = 370). Read More

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Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain.

Schizophr Bull 2021 May 11. Epub 2021 May 11.

Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Hypocretin (also called orexin) regulates various functions, such as sleep-wake rhythms, attention, cognition, and energy balance, which show significant changes in schizophrenia (SCZ). We aimed to identify alterations in the hypocretin system in SCZ patients. We measured plasma hypocretin-1 levels in SCZ patients and healthy controls and found significantly decreased plasma hypocretin-1 levels in SCZ patients, which was mainly due to a significant decrease in female SCZ patients compared with female controls. Read More

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