155,459 results match your criteria Schizophrenia


Structural alterations of amygdala and hypothalamus contribute to catatonia.

Schizophr Res 2022 May 18. Epub 2022 May 18.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:

At present, current diagnostic criteria and systems neglect affective symptom expression in catatonia. This potentially serious omission could explain why putative contributions of limbic system structures, such as amygdala, hippocampus or hypothalamus, to catatonia in schizophrenia spectrum disorders (SSD) have been scarcely investigated so far. To determine whether topographical alterations of the amygdala, hippocampus and hypothalamus contribute to catatonia in SSD patients, we conducted structural magnetic resonance imaging (MRI) of SSD patients with (SSD-Cat, n = 30) and without (SSD-nonCat, n = 28) catatonia as defined by a Northoff Catatonia Rating Scale (NCRS) total score of ≥3 and =0, respectively, in comparison with healthy controls (n = 20). Read More

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Variability and concordance of sulcal patterns in the orbitofrontal cortex: A twin study.

Psychiatry Res Neuroimaging 2022 May 14;324:111492. Epub 2022 May 14.

Geisinger Autism and Developmental Medicine Institute, 120 Hamm Drive, Suite 2A, Lewisburg, PA 17837, United States.

Sulcogyral patterns have been identified in the orbitofrontal cortex (OFC) based on the continuity of the medial and lateral orbital sulci. Pattern types are named according to their frequency in the population, with Type I present in ∼60%, Type II in ∼25%, Type III in ∼10%, and Type IV in ∼5%. Previous work has demonstrated that psychiatric conditions with high estimated heritability (e. Read More

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Differentiating autoimmune encephalitis from schizophrenia spectrum disorders among patients with first-episode psychosis.

J Psychiatr Res 2022 May 13;151:419-426. Epub 2022 May 13.

Department of Neuropsychiatry, Ashikaga Red Cross Hospital, Ashikaga, Tochigi, 326-0843, Japan; Department of Neuropsychiatry, Keio University School of Medicine, Shinjuku, Tokyo, 160-8582, Japan. Electronic address:

Background: Although differential diagnosis between autoimmune encephalitis and schizophrenia spectrum disorders is crucial for a good outcome, the psychiatric symptoms that distinguish these two conditions have not been identified even though psychiatric symptoms are often the main manifestation of autoimmune encephalitis. Also, there are many situations in clinical psychiatry in which laboratory testing and imaging studies are not available. Because no comparative study of the psychiatric symptoms between these two conditions has been carried out, we explored diagnostically useful psychiatric symptoms in a retrospective case-control study. Read More

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Bioinformatics-based screening of key genes between maternal preeclampsia and offspring schizophrenia.

Biochem Biophys Res Commun 2022 May 13;615:1-8. Epub 2022 May 13.

Mental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Converging lines of evidence suggest an association between schizophrenia and prenatal neurodevelopmental disorders. Preeclampsia is a multisystem disease based on the coexistence of pregnancy and elevated blood pressure, which increases the risk for offspring abnormal neurodevelopment. Previous studies have showed maternal preeclampsia is associated with an increased risk of offspring schizophrenia, but the molecular mechanism remains unclear. Read More

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Neural Activation in the Ventromedial Prefrontal Cortex Precedes Conscious Experience of Being in or Out of a Transient Hallucinatory State.

Schizophr Bull 2022 May 21. Epub 2022 May 21.

Rijks Universiteit Groningen (RUG), Department of Biomedical Sciences of Cells and Systems and Department of Psychiatry, University Medical Center  Groningen (UMCG), Netherlands.

Background And Hypotheses: Auditory verbal hallucinations (AVHs) is not only a common symptom in schizophrenia but also observed in individuals in the general population. Despite extensive research, AVHs are poorly understood, especially their underlying neuronal architecture. Neuroimaging methods have been used to identify brain areas and networks that are activated during hallucinations. Read More

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Using the Structure of Evaluative Components as a basis for comparing the oral narratives of schizophrenics and healthy individuals.

J Psycholinguist Res 2022 May 20. Epub 2022 May 20.

Department of Psychology, Ferdowsi University of Mashhad, Mashhad, Iran.

In this study, evaluative language in narratives of 15 healthy and 15 schizophrenic females was compared using the Structure of Evaluative Components. The two groups were matched for chronological age and socioeconomic status. A movie named "The Pear Film" ( http://chafe. Read More

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Structural brain imaging abnormalities correlate with positive symptom in schizophrenia.

Neurosci Lett 2022 May 17:136683. Epub 2022 May 17.

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21288, USA.

Accumulating evidence indicates neuroanatomical mechanisms underlying positive symptoms in schizophrenia; however, the exact structural determinants of positive symptoms remain unclear. This study aimed to investigate associations between positive symptoms and structural brain changes, including alterations in grey matter (GM) volume and cortical thickness, in patients with first-episode schizophrenia (FES). This study included 44 patients with FES and 48 healthy controls (HCs). Read More

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A network analysis on the relationship between loneliness and schizotypy.

J Affect Disord 2022 May 17. Epub 2022 May 17.

Department of Psychology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.

Background: Schizotypy is a multidimensional personality trait related to the heightened risk for the development of schizophrenia spectrum disorders. While it has been suggested that loneliness may be associated with schizotypy in general, whether it relates to the specific schizotypal traits differentially remains unknown. Besides, as loneliness often co-occurs with depression and anxiety, it is important to delineate its relationship with schizotypy in consideration of these co-occurring emotional disturbances. Read More

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The relationship of antipsychotic treatment with reduced brown adipose tissue activity in patients with schizophrenia.

Psychoneuroendocrinology 2022 Apr 25;142:105775. Epub 2022 Apr 25.

Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taiwan; Psychiatric Research Center, Taipei Medical University Hospital, 250 Wu-Hsing Street, 110 Taipei, Taiwan. Electronic address:

Background: Antipsychotic drug (APD) treatment has been associated with metabolic abnormalities. Brown adipose tissue (BAT) is the main site of adaptive thermogenesis and secretes various metabolism-improving factors known as batokines. We explored the association of BAT activity with APD treatment and metabolic abnormalities in patients with schizophrenia by measuring the blood levels of bone morphogenetic protein 8b (BMP8b), a batokine secreted by mature BAT. Read More

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The network structure of cognitive deficits in first episode psychosis patients.

Schizophr Res 2022 May 17;244:46-54. Epub 2022 May 17.

Department of Psychiatry, Hospital Universitario de Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNa), Pamplona, Spain. Electronic address:

Network analysis is an important conceptual and analytical approach in mental health research. However, few studies have used network analysis to examine the structure of cognitive performance in psychotic disorders. We examined the network structure of the cognitive scores of a sample of 207 first-episode psychosis (FEP) patients and 188 healthy controls. Read More

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Quantitative detection of methylated SOCS-1 in schizophrenia and bipolar disorder considering SOCS-1 -1478CA/del polymorphism and clinical parameters.

Ir J Med Sci 2022 May 20. Epub 2022 May 20.

Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: We aimed to investigate the quantitative detection of methylated suppressor of cytokine signaling-1 (SOCS-1) in schizophrenia (SCZ) and bipolar disorder (BD), considering SOCS-1 -1478CA/del polymorphism and clinical parameters.

Methods: Our research is a case-control study in which 114 patients with SCZ, 86 patients with BD, and 80 volunteers as a healthy group participated. Bisulfite-converted DNA samples were analyzed using the real-time quantitative methylation-specific PCR (qMS-PCR) method to measure the methylation level of the SOCS-1 gene. Read More

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Minimal Effects of Cariprazine on Prolactin Levels in Bipolar Disorder and Schizophrenia.

Neuropsychiatr Dis Treat 2022 12;18:995-1011. Epub 2022 May 12.

AbbVie, Madison, NJ, USA.

Background: Many medications used to treat schizophrenia and bipolar I disorder are linked to hyperprolactinemia. The effects of cariprazine, a dopamine D/D receptor partial agonist, on prolactin levels in patients with schizophrenia or bipolar I disorder were evaluated.

Methods: Effects on prolactin were evaluated using pooled data from randomized, double-blind, placebo-controlled studies in patients with schizophrenia (4 studies; 6-week duration; cariprazine 1. Read More

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Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function.

Nat Neurosci 2022 May 19. Epub 2022 May 19.

Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Impaired cortical maturation is a postulated mechanism in the etiology of neurodevelopmental disorders, including schizophrenia. In the sensory cortex, activity relayed by the thalamus during a postnatal sensitive period is essential for proper cortical maturation. Whether thalamic activity also shapes prefrontal cortical maturation is unknown. Read More

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[Late-Onset Dyskinesia Occurring During Antipsychotic Treatment for Schizophrenia: Management of Tardive Dyskinesia Based on the Latest Knowledge].

Brain Nerve 2022 May;74(5):571-574

Department of Neurology, Wakayama Medical University.

Tardive dyskinesia is a drug-induced involuntary movement related to long-term use of dopamine receptor-blocking agents. If there is no improvement upon discontinuation or change in the causative drug, treatment needs to be initiated. The most effective drug is the vesicular monoamine transporter 2 selective inhibitor. Read More

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[Late-Onset Dyskinesia Occurring During Antipsychotic Treatment for Schizophrenia: Treatments for Tardive Dyskinesia].

Authors:
Masahiro Nomoto

Brain Nerve 2022 May;74(5):565-570

Department of Neurology, Saiseikai Imabari Hospital.

Tardive dyskinesia is recognized as buccolingual dyskinesia, but also includes various involuntary movements, such as chorea, dystonia, myoclonus, and tremor. Tardive dyskinesia can be treated depending on the type of movement disorder present. Antipsychotics causing tardive dyskinesia should be reduced in dosage or should be discontinued. Read More

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Association between intimate partner violence and prenatal anxiety and depression in pregnant women: a cross-sectional survey during the COVID-19 epidemic in Shenzhen, China.

BMJ Open 2022 May 19;12(5):e055333. Epub 2022 May 19.

Department of Healthcare, Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, China

Objectives: Intimate partner violence (IPV) against women remains a major global public health problem with harmful consequences for individuals and society. People's lifestyles have been greatly affected by the COVID-19 pandemic. This study investigated the prevalence of and relationship between IPV and anxiety and depression in pregnant Chinese women during the pandemic. Read More

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Delusional Perception Revisited.

Psychopathology 2022 May 19:1-10. Epub 2022 May 19.

Mental Health Center Amager, Copenhagen University Hospital, Mental Health Services, CPH, Copenhagen, Denmark.

Delusional perception designates a sudden, idiosyncratic, and often self-referential delusion triggered by a neutral perceptual content. In classical psychopathology, delusional perception was considered almost pathognomonic for schizophrenia. Since delusional perception has been erased from ICD-11 and always been absent in DSM, it risks slipping out of clinical awareness. Read More

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Biomarkers identification for Schizophrenia via VAE and GSDAE-based data augmentation.

Comput Biol Med 2022 May 13;146:105603. Epub 2022 May 13.

Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. Electronic address:

Deep learning has made great progress in analyzing MRI data, while the MRI data with high dimensional but small sample size (HDSSS) brings many limitations to biomarkers identification. Few-shot learning has been proposed to solve such problems and data augmentation is a typical method of it. The variational auto-encoder (VAE) is a generative method based on variational Bayesian inference that is used for data augmentation. Read More

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Modified climbing fiber/Purkinje cell synaptic connectivity in the cerebellum of the neonatal phencyclidine model of schizophrenia.

Proc Natl Acad Sci U S A 2022 May 19;119(21):e2122544119. Epub 2022 May 19.

Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Université PSL, 75005 Paris, France.

SignificanceSynaptogenesis and neural network remodeling are at their maximum during the perinatal period of human brain development. Perturbations of this highly sensitive stage might underlie the etiology of neurodevelopmental disorders. Subchronic neonatal administration of phencyclidine, a drug of abuse, has been used to model schizophrenia in rodents. Read More

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Early Improvement as a Predictor of Later Response to Lurasidone in Schizophrenia from Japan Trials: A Diagnostic Test.

Psychiatry Clin Neurosci 2022 May 19. Epub 2022 May 19.

Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470-1192, Japan.

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The 'insanity' of Lady Durham.

Authors:
Ruth Paley

Hist Psychiatry 2022 Jun;33(2):217-229

Visiting Fellow, Oxford Brookes University, UK.

This essay draws on evidence in a late nineteenth-century court case and surviving medical notes to provide a case study of a hitherto unidentified case of Autism Spectrum Disorder. The case is particularly interesting in that it not only appears to be the first identification of historical ASD in a female, but also because the patient subsequently developed symptoms of psychosis suggestive of schizophrenia or schizoaffective disorder. The unusual survival of detailed medical notes also throws light on the ways in which a difficult patient was treated by supposedly enlightened pioneers of psychiatry. Read More

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Risk Factors For Hearing Decline From Childhood To Early Adolescence.

Laryngoscope 2022 May 19. Epub 2022 May 19.

Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.

Objective: To identify risk factors of hearing decline between 9 and 13 years of age. The risk factors examined included sociodemographic, health, and lifestyle-related factors.

Methods: This study was embedded within a population-based prospective cohort study from fetal life onwards in the Netherlands. Read More

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Glutamatergic dysfunction is associated with phenotypes of VGF-overexpressing mice.

Exp Brain Res 2022 May 19. Epub 2022 May 19.

Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan.

VGF nerve growth factor inducible (VGF) is a neuropeptide precursor, which is induced by several neurotrophic factors, including nerve growth factor and brain-derived neurotrophic factor. Clinically, an upregulation of VGF levels has been reported in the cerebrospinal fluid and prefrontal cortex of patients with schizophrenia. In our previous study, mice overexpressing VGF exhibited schizophrenia-related behaviors. Read More

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"You are trying to teach us to think more slowly!" Adapting Metacognitive Training for the acute care setting - a case report.

Clin Psychol Psychother 2022 May 19. Epub 2022 May 19.

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Psychological group interventions for the acute inpatient care setting are scarce. Whereas Metacognitive Training for patients with psychosis (MCT) provides a widely accessible, easy-to-implement intervention for patients with mild to moderate symptoms, it is less adequate for the acute care setting with respect to length and density of information. We present the adaptation process and the resulting adaptation of MCT, MCT-Acute, for the acute inpatient care setting. Read More

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Feasibility, acceptability and evaluation of meditation to augment Yoga practice among persons diagnosed with schizophrenia.

Acta Neuropsychiatr 2022 May 19:1-37. Epub 2022 May 19.

Department of Psychiatry, Centre of Excellence in Mental Health, Atal Bihari Vajpayee Institute of Medical Sciences-Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Objective: To design a meditation protocol and test its feasibility, acceptability and efficacy in conjunction with YT for persons with schizophrenia (SZ).

Methods: The meditation protocol consisted of Anapana (observing normal respiration) and Yoga Nidra (supine, restful awareness). In a single blind randomized controlled trial, medicated and clinically stable outpatients diagnosed with SZ were randomized to receive treatment as usual (TAU), TAU augmented with yoga training (YT), or TAU augmented with meditation and yoga training (MYT) for three weeks (N=145). Read More

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Dietary Supplementation With Oil Promotes Remyelination in a Mouse Model of Multiple Sclerosis.

Front Neurosci 2022 2;16:860280. Epub 2022 May 2.

College of Veterinary Medicine, Northwest A&F University, Yangling, China.

Background: Multiple sclerosis is a chronic demyelinating disease of uncertain etiology. Traditional treatment methods produce more adverse effects. Epidemiological and clinical treatment findings showed that unknown environmental factors contribute to the etiology of MS and that diet is a commonly assumed factor. Read More

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Unhealthy diet in schizophrenia spectrum disorders.

Curr Opin Psychiatry 2022 May 17;35(3):177-185. Epub 2022 Mar 17.

Department of Biomedical Sciences of Cells and Systems.

Purpose Of Review: The high mortality and prevalence of metabolic syndrome in patients with schizophrenia spectrum disorders (SSD) is maintained by poor diet. This narrative review summarizes recent literature to provide a reflection of current eating habits, dietary preferences, and nutritional status of SSD patients. Elucidating these factors provides new insights for potential lifestyle treatment strategies for SSD. Read More

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Antipsychotika machen dosisabhängig dick.

Authors:
Alkomiet Hasan

MMW Fortschr Med 2022 May;164(10):22-23

Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Universität Augsburg, Dr.-Mack-Str. 1, 86156, Augsburg, Deutschland.

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