143,278 results match your criteria Schizophrenia


A molecular approach to treating cognition in schizophrenia by calcium channel blockade: An open-label pilot study of the calcium-channel antagonist isradipine.

Schizophr Res Cogn 2020 Sep 18;21:100180. Epub 2020 May 18.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Cognitive impairment is a prominent and difficult to treat symptom in schizophrenia (SZ), which is directly related to functional disability. A variant in the gene coding for the alpha 1C subunit of L-type voltage gated calcium channel (CACNA1C) has been shown to negatively affect several neurocognitive domains. We conducted a 4-week, open label, pilot study of isradipine, a calcium channel blocker, to determine its feasibility, safety, and efficacy in improving cognition in SZ patients. Read More

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http://dx.doi.org/10.1016/j.scog.2020.100180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235642PMC
September 2020

A higher degree of insight impairment in stabilized schizophrenia patients is associated with reduced cardiac vagal tone as indexed by resting-state high-frequency heart rate variability.

Asian J Psychiatr 2020 May 16;53:102171. Epub 2020 May 16.

Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address:

Varying degrees of impaired clinical insight in schizophrenia differentially impact medication adherence and clinical outcomes, prompting in-depth investigations of the deficits. Research is scarce on the differences in peripheral physiological markers between varying degrees of impaired insight. The aims of this study were to examine the differences in (1) resting-state high-frequency heart rate variability (HF-HRV) and (2) crucial clinical outcomes between schizophrenia patients with varying degrees of insight impairment as measured by the Positive and Negative Syndrome Scale (PANSS) item G12 (lack of judgment and insight). Read More

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http://dx.doi.org/10.1016/j.ajp.2020.102171DOI Listing

Association of antipsychotics adherence and cardiovascular disease among newly diagnosed schizophrenia patients: A national cohort among Koreans.

Asian J Psychiatr 2020 May 12;52:102161. Epub 2020 May 12.

Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea; Department of Family Medicine, Seoul National University Hospital, 127, Yongmasan-ro, Gwangjin-gu, Seoul, South Korea. Electronic address:

Background: The effect of antipsychotics adherence on the risk of cardiovascular disease (CVD) among schizophrenia patients has not been studied. While antipsychotic adherence is favorable for all-cause mortality, its association with CVD incidence is unclear due to the potential risk of CVD caused by antipsychotics.

Methods: Using the Korean National Health Insurance Service Database, we constructed a case-cohort of 80,581 newly-diagnosed schizophrenia patients between 2004 and 2013 from a cohort of all Koreans 20-40 years old. Read More

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http://dx.doi.org/10.1016/j.ajp.2020.102161DOI Listing

Neuropsychological development in the child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder: A two-year follow-up comparative study.

Prog Neuropsychopharmacol Biol Psychiatry 2020 May 23:109972. Epub 2020 May 23.

Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain; Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic de Neurociències, Hospital Clínic Universitari, Barcelona 2017SGR881, Spain; Institut d'Investigació Biomèdica August Pi i Sunyer, IDIBAPS, Barcelona, Spain; Department of Medicine, University of Barcelona, Spain.

There has been growing scientific evidence in recent years that schizophrenia and bipolar disorder share clinical, cognitive, neuroimaging and genetic characteristics. This overlap might also be present in their offspring, who have an increased risk of developing both disorders. Comparing the characteristics of these samples may have important implications for understanding etiological processes. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.109972DOI Listing

Switch, a new intervention that targets motivational negative symptoms in people with schizophrenia: An uncontrolled pilot study.

J Clin Psychol 2020 May 26. Epub 2020 May 26.

Psychology and Neuroscience of Cognition Research Unit, Université de Liège, Liège, Belgium.

Objective: People diagnosed with schizophrenia experience difficulties in their daily life, which is best explained by motivational negative symptoms. This study explores the feasibility, acceptability, and efficacy of Switch, a new multifactorial intervention that targets motivational deficits.

Method: Eight participants with schizophrenia or schizoaffective disorder followed around 30 individual sessions of Switch over 12 months. Read More

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http://dx.doi.org/10.1002/jclp.22963DOI Listing

Positive and Useful Voices in Patients With Schizophrenia: Prevalence, Course, Characteristics, and Correlates.

J Nerv Ment Dis 2020 May 20. Epub 2020 May 20.

Psychiatry Department, Hospital Clínico.

Auditory verbal hallucinations (AVHs) in schizophrenia have been characterized by their negative emotional valence. However, positive hallucinations have also been described. The objective of the current study is to explore the prevalence, course, characteristics, and associations of positive and useful voices. Read More

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http://dx.doi.org/10.1097/NMD.0000000000001183DOI Listing

Auditory Verbal Hallucinations in Schizophrenia: Mode of Onset and Disclosure.

J Nerv Ment Dis 2020 May 22. Epub 2020 May 22.

Mental Health Center Glostrup, University Hospital Copenhagen, Broendby.

Recent reviews on auditory verbal hallucinations (AVHs) advocate a qualitative and interdisciplinary research that not only is limited to single descriptive features, but also involves contextual issues and co-occurring psychopathology. In this study of mainly readmitted patients with the International Classification of Diseases, Tenth Revision, diagnosis of paranoid schizophrenia and experiencing AVH, we performed a qualitative, phenomenologically oriented interview study. The focus was on the beginning of hallucinatory experiences, time to disclosure of the symptom, and the context surrounding the disclosure. Read More

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http://dx.doi.org/10.1097/NMD.0000000000001179DOI Listing

A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens.

Pain 2020 May 19. Epub 2020 May 19.

Department of Pharmacology, University of Arizona, Tucson, AZ 85724.

Diseases and disorders such as Parkinson's, schizophrenia, and chronic pain are characterized by altered mesolimbic dopaminergic neurotransmission. Dopamine release in the nucleus accumbens (NAc) influences behavior through both tonic and phasic signaling. Tonic dopamine levels are hypothesized to inversely regulate phasic signals via dopamine D2 receptor feedback inhibition. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001925DOI Listing

Enhanced phosphorylation of S6 protein in mouse cortical layer V and subplate neurons.

Neuroreport 2020 May 21. Epub 2020 May 21.

College of Pharmacy.

The mammalian neocortex is composed of six major layers of neurons. Each group of neurons in the cortical layers has distinct characteristics based on the expression of specific genes and connectivity patterns of neural circuits. Neuronal subtype transition and regional identity acquisition are established by temporal cues and interaction between several transcription factors during neurogenesis. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001479DOI Listing

Schizophrenia and schizophrenia spectrum disorders.

Authors:
Matthew Wright

JAAPA 2020 Jun;33(6):46-47

Matthew Wright is a faculty member in the PA program at Rutgers University in Piscataway, N.J., and works clinically in family medicine in Hunterdon County, N.J. The author has disclosed no potential conflicts of interest, financial or otherwise.

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http://dx.doi.org/10.1097/01.JAA.0000662412.51169.bfDOI Listing

Factors associated with high-dose antipsychotic prescriptions in outpatients with schizophrenia: An analysis of claims data from a Japanese prefecture.

Neuropsychopharmacol Rep 2020 May 26. Epub 2020 May 26.

Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Antipsychotics are commonly prescribed in high doses in combination with multiple psychotropic drugs. This study focused on the high-dose antipsychotic prescriptions in patients with schizophrenia, while aiming to identify their associations with patients' characteristics and concurrent psychotropic prescriptions.

Methods: This cross-sectional study used claims data from a prefecture in Japan, between October 2014 and March 2015, to investigate antipsychotic prescriptions in adult outpatients with schizophrenia. Read More

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http://dx.doi.org/10.1002/npr2.12109DOI Listing

Parasympathetic activity as a potential biomarker of negative symptoms in patients with schizophrenia.

Asia Pac Psychiatry 2020 May 26:e12392. Epub 2020 May 26.

Department of Psychiatry, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan.

Introduction: Autonomic dysfunction in patients with schizophrenia has raised concern considering the higher cardiovascular mortality and morbidity rate. This phenomenon has been demonstrated using various measurements and is inferred to be associated with demographics, medical treatment, and psychopathology. However, few have targeted the role of negative symptoms within schizophrenia. Read More

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http://dx.doi.org/10.1111/appy.12392DOI Listing

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.

EMBO J 2020 May 25:e104136. Epub 2020 May 25.

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco (UCSF), San Francisco, CA, USA.

Developmental synaptic remodeling is important for the formation of precise neural circuitry, and its disruption has been linked to neurodevelopmental disorders such as autism and schizophrenia. Microglia prune synapses, but integration of this synapse pruning with overlapping and concurrent neurodevelopmental processes, remains elusive. Adhesion G protein-coupled receptor ADGRG1/GPR56 controls multiple aspects of brain development in a cell type-specific manner: In neural progenitor cells, GPR56 regulates cortical lamination, whereas in oligodendrocyte progenitor cells, GPR56 controls developmental myelination and myelin repair. Read More

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http://dx.doi.org/10.15252/embj.2019104136DOI Listing

Sleep disturbance and quality of life in clinically stable inpatients with schizophrenia in rural China.

Qual Life Res 2020 May 25. Epub 2020 May 25.

Chifeng Anding Hospital, Chifeng, the Autonomous Region, China.

Background: Studies have identified numerous factors that may affect the sleep quality and quality of life (QOL) in outpatients with schizophrenia. However, the clinically stable inpatients who represent a large proportion of the population with schizophrenia in China have not received enough attention. The present study was performed to explore the sociodemographic and clinical correlates of sleep disturbance and QOL in clinically stable inpatients with schizophrenia in rural China. Read More

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http://dx.doi.org/10.1007/s11136-020-02541-2DOI Listing

Activators of α7 nAChR as Potential Therapeutics for Cognitive Impairment.

Curr Top Behav Neurosci 2020 May 26. Epub 2020 May 26.

Department of Neuroscience Research, Merck & Co. Inc., West Point, PA, USA.

The α7 nicotinic acetylcholine receptor (nAChR) is a promising target for the treatment of cognitive deficits associated with psychiatric and neurological disorders, including schizophrenia and Alzheimer's disease (AD). Several α7 nAChR agonists and positive allosteric modulators (PAMs) have demonstrated procognitive effects in preclinical models and early clinical trials. However, despite intense research efforts in the pharmaceutical industry and academia, none of the α7 nAChR ligands has been approved for clinical use. Read More

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http://dx.doi.org/10.1007/7854_2020_140DOI Listing

Patients with Schizophrenia Undergoing Gastric Bypass Surgery: a Case Series Study.

Obes Surg 2020 May 25. Epub 2020 May 25.

Department of Psychiatry - Faculty of Medical Sciences, State University of Campinas (FCM-UNICAMP), Campinas, SP, Brazil.

Purpose: Obesity affects approximately 45-55% of persons with schizophrenia and is more difficult to manage in these individuals than in the general population, apart from being an additional factor for morbidity and premature mortality. Although bariatric surgery is considered the most effective long-term treatment for severe obesity, there are few reports on the outcomes of this procedure in persons with schizophrenia. This study aimed to evaluate weight loss and psychiatric symptoms in persons with obesity and schizophrenia after bariatric surgery. Read More

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http://dx.doi.org/10.1007/s11695-020-04702-1DOI Listing

Myosin XVI.

Adv Exp Med Biol 2020 ;1239:405-419

Department of Biophysics, University of Pécs, Medical School, Pécs, Hungary.

Myosin XVI (Myo16), a vertebrate-specific motor protein, is a recently discovered member of the myosin superfamily. The detailed functionality regarding myosin XVI requires elucidating or clarification; however, it appears to portray an important role in neural development and in the proper functioning of the nervous system. It is expressed in the largest amount in neural tissues in the late embryonic-early postnatal period, specifically the time in which neuronal cell migration and dendritic elaboration coincide. Read More

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http://dx.doi.org/10.1007/978-3-030-38062-5_18DOI Listing
January 2020

Integrative In Silico Analysis of Genome-Wide DNA Methylation Profiles in Schizophrenia.

J Mol Neurosci 2020 May 26. Epub 2020 May 26.

Center for Psychosocial Studies for Latin America and the Caribbean, School of Psychosocial Therapies, Universidad Antonio Nariño, Bogotá, Colombia.

Schizophrenia (SZ) is a complex and severe psychiatric disorder, which has a global lifetime prevalence of 0.4% and a heritability of around 0.81. Read More

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http://dx.doi.org/10.1007/s12031-020-01585-wDOI Listing

Recent trends in mental illness and omega-3 fatty acids.

J Neural Transm (Vienna) 2020 May 25. Epub 2020 May 25.

Department of Neuropsychiatry, Unit of Translation Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

Although it is clear that nutrition affects physical and metabolic functions in humans, the importance of nutrition in mental illness has often been overlooked. Following a report by Hibbeln (Lancet 351:1213, 1998) published in The Lancet, which suggested that depression rates and fish consumption were inversely correlated, the relationships between a variety of nutritional/epidemiological treatments and neuropsychiatric disorders have received increased attention. In particular, many studies have been conducted on the omega-3 fatty acid mechanism of action in pathophysiological aspects of various neuropsychiatric disorders. Read More

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http://dx.doi.org/10.1007/s00702-020-02212-zDOI Listing

Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression.

Nat Neurosci 2020 May 25. Epub 2020 May 25.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

Neuronal activation induces rapid transcription of immediate early genes (IEGs) and longer-term chromatin remodeling around secondary response genes (SRGs). Here, we use high-resolution chromosome-conformation-capture carbon-copy sequencing (5C-seq) to elucidate the extent to which long-range chromatin loops are altered during short- and long-term changes in neural activity. We find that more than 10% of loops surrounding select IEGs, SRGs, and synaptic genes are induced de novo during cortical neuron activation. Read More

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http://dx.doi.org/10.1038/s41593-020-0634-6DOI Listing

Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms.

Schizophr Res 2020 May 22. Epub 2020 May 22.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

Oxidative stress in excess may be engaged in the pathophysiological development of schizophrenia (SCZ). Previous research showed altered activity of superoxide dismutase (SOD) in patients suffering from SCZ, with inconsistent results. However, few studies have analyzed the relationship between SOD activity and psychopathological symptoms in never-treated first-episode (NTFE) patients with SCZ. Read More

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http://dx.doi.org/10.1016/j.schres.2020.05.032DOI Listing

Chronic stress, structural exposures and neurobiological mechanisms: A stimulation, discrepancy and deprivation model of psychosis.

Int Rev Neurobiol 2020 5;152:41-69. Epub 2019 Dec 5.

Northwestern University, Evanston, IL, United States. Electronic address:

Chronic stress exposure has been established as a key vulnerability factor for developing psychotic disorders, including schizophrenia. A structural, or systems level perspective, has often been lacking in conceptualizations of chronic stress for psychotic disorders. The current review thus identified three subtypes of structural exposures. Read More

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http://dx.doi.org/10.1016/bs.irn.2019.11.004DOI Listing
December 2019

Gene expression and response prediction to amisulpride in the OPTiMiSE first episode psychoses.

Neuropsychopharmacology 2020 May 25. Epub 2020 May 25.

Inserm U955, Psychiatrie Translationnelle, Créteil, France.

A fundamental shortcoming in the current treatment of schizophrenia is the lack of valid criteria to predict who will respond to antipsychotic treatment. The identification of blood-based biological markers of the therapeutic response would enable clinicians to identify the subgroup of patients in whom conventional antipsychotic treatment is ineffective and offer alternative treatments. As part of the Optimisation of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) programme, we conducted an RNA-Seq analysis on 188 subjects with first episode psychosis, all of whom were subsequently treated with amisulpride for 4 weeks. Read More

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http://dx.doi.org/10.1038/s41386-020-0703-2DOI Listing

One-pot reaction for determination of Asenapine maleate through facile complex formation with xanthine based dye: Application to content uniformity test.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 14;239:118474. Epub 2020 May 14.

Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Asenapine maleate was approved by the FDA for the treatment of schizophrenia and mania or mixed episodes with bipolar I disorder. In the present article, two spectroscopic methods were developed and validated for the determination of asenapine. Both methods depend on association complex formation between xanthine based dye (eosin Y) and the cited drug in acetate buffer pH = 3. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118474DOI Listing

Associations between facial affect recognition and neurocognition in subjects at ultra-high risk for psychosis: A case-control study.

Psychiatry Res 2020 Apr 20;290:112969. Epub 2020 Apr 20.

Copenhagen Research Center for Mental Health - CORE, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Copenhagen University Hospital, Glostrup, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen, Denmark.

The nature of facial affect recognition (FAR) deficits in subjects at ultra-high risk (UHR) for psychosis remains unclear. In schizophrenia, associations between FAR impairment and poor neurocognition have been demonstrated meta-analytically, but this potential link is understudied in the UHR population. Our study investigated a cross-sectional sample of UHR subjects (n = 22) and healthy controls (n = 50), with the Degraded Facial Affect Recognition (DFAR) Task and a neurocognitive test battery. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.112969DOI Listing

The 12-year trend report of antipsychotic usage in a nationwide claims database derived from four million people in Japan.

J Psychiatr Res 2020 May 13;127:28-34. Epub 2020 May 13.

Department of Pharmacy, Osaka Medical College Hospital, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.

The current study aimed to describe the use of antipsychotics to clarify the gap between clinical guidelines and health care practice in Japan. We used data from the JMDC Claims Database (JMDC Inc., Tokyo, Japan), a nationwide claims database, from 2005 to 2016. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2020.05.012DOI Listing

Regional, cellular and species difference of two key neuroinflammatory genes implicated in schizophrenia.

Brain Behav Immun 2020 May 22. Epub 2020 May 22.

Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick NSW 2031, Australia; School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney NSW 2052, Australia; Department of Neuroscience & Physiology, Upstate Medical University, Syracuse, New York 13210, USA. Electronic address:

The transcription factor nuclear factor kappa B (NF-κB) regulates the expression of many inflammatory genes that are overexpressed in a subset of people with schizophrenia. Transcriptional reduction in one NF-κB inhibitor, Human Immunodeficiency Virus Enhancer Binding Protein 2 (HIVEP2), is found in the brain of patients, aligning with evidence of NF-κB over-activity. Cellular co-expression of HIVEP2 and cytokine transcripts is a prerequisite for a direct effect of HIVEP2 on pro-inflammatory transcription, and we do not know if changes in HIVEP2 and markers of neuroinflammation are occurring in the same brain cell type. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.05.055DOI Listing

Common variants in FAN1, located in 15q13.3, confer risk for schizophrenia and bipolar disorder in Han Chinese.

Prog Neuropsychopharmacol Biol Psychiatry 2020 May 22:109973. Epub 2020 May 22.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University, Shanghai 200030, PR China; Shanghai Key laboratory of Sleep Disordered Breathing, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China; Affiliated Hospital of Qingdao University, Biomedical Sciences Institute of Qingdao University, (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, Shandong 266003, PR China; Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai 200030, PR China; Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, Shanghai 200030, PR China; Shanghai Changning Mental Health Center, Shanghai 200030, PR China; Department of Psychiatry, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, PR China. Electronic address:

Multiple genetic risk factors have been associated with psychiatric disorders which provides the genetic insight to these disorders; however, the etiology of these disorders is still elusive. 15q13.3 was previously associated with schizophrenia, bipolar and other neurodevelopmental disorders. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.109973DOI Listing

Emerging 5-HT receptor antagonists for the treatment of Schizophrenia.

Expert Opin Emerg Drugs 2020 May 23. Epub 2020 May 23.

University of Miami Miller School of Medicine , Miami, USA.

Introduction: While antipsychotics have been generally successful in treating psychosis in schizophrenia, there is a major treatment gap for negative symptoms and cognitive deficits. Given that these aspects of the disease contribute to poor functional outcomes independently of positive symptoms, treatments would have profound implications for quality of life. The 5-HT- receptor has been considered a potential target for interventions aimed at negative and cognitive symptoms and multiple antagonists and inverse agonists of this receptor have been tested. Read More

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http://dx.doi.org/10.1080/14728214.2020.1773792DOI Listing

Precision psychiatry with immunological and cognitive biomarkers: a multi-domain prediction for the diagnosis of bipolar disorder or schizophrenia using machine learning.

Transl Psychiatry 2020 May 24;10(1):162. Epub 2020 May 24.

AP-HP, Université Paris Est Créteil, Department of Psychiatry and Addictology, Mondor University Hospital, DMU IMPACT, Translational Neuro-Psychiatry laboratory, INSERM U955, Créteil, France.

Precision psychiatry is attracting increasing attention lately as a recognized priority. One of the goals of precision psychiatry is to develop tools capable of aiding a clinically informed psychiatric diagnosis objectively. Cognitive, inflammatory and immunological factors are altered in both bipolar disorder (BD) and schizophrenia (SZ), however, most of these alterations do not respect diagnostic boundaries from a phenomenological perspective and possess great variability in different individuals with the same phenotypic diagnosis and, consequently, none so far has proven to have the ability of reliably aiding in the differential diagnosis of BD and SZ. Read More

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http://dx.doi.org/10.1038/s41398-020-0836-4DOI Listing
May 2020
4.360 Impact Factor

Genetic stratification of depression in UK Biobank.

Transl Psychiatry 2020 May 24;10(1):163. Epub 2020 May 24.

Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.

Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Read More

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http://dx.doi.org/10.1038/s41398-020-0848-0DOI Listing

Improving insight to facilitate antipsychotic medication adherence in patients with schizophrenia.

Clin Neurophysiol 2020 May 11. Epub 2020 May 11.

Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2020.05.004DOI Listing

Dysfunctional connectivity in posterior brain regions involved in cognitive control in schizophrenia: A preliminary fMRI study.

J Clin Neurosci 2020 May 21. Epub 2020 May 21.

Centre Ressource de Rehabilitation Psychosociale, Centre Hospitalier le Vinatier & UMR 5229, CNRS & Université Lyon 1, France.

Cognitive control, the ability to use goal-directed information to guide behaviour, is impaired in schizophrenia, and mainly related to dysfunctions within the fronto-posterior brain network. However, cognitive control is a broad cognitive function encompassing distinct sub-processes that, until now, studies have failed to separate and relate to specific brain regions. The goal of this preliminary fMRI study is to investigate the functional specialization of posterior brain regions, and their functional interaction with lateral prefrontal cortex (LPFC) regions, in schizophrenia. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.089DOI Listing

Thalamic and striato-pallidal volumes in schizophrenia patients and individuals at risk for psychosis: A multi-atlas segmentation study.

Schizophr Res 2020 May 21. Epub 2020 May 21.

Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan.

Despite previous neuroimaging studies demonstrating morphological abnormalities of the thalamus and other subcortical structures in patients with schizophrenia, the potential role of the thalamus and its subdivisions in the pathophysiology of this illness remains elusive. It is also unclear whether similar changes of these structures occur in individuals at high risk for psychosis. In this study, magnetic resonance imaging was employed with the Multiple Automatically Generated Templates (MAGeT) brain segmentation algorithm to determine volumes of the thalamic subdivisions, the striatum (caudate, putamen, and nucleus accumbens), and the globus pallidus in 62 patients with schizophrenia, 38 individuals with an at-risk mental state (ARMS) [4 of whom (10. Read More

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http://dx.doi.org/10.1016/j.schres.2020.04.016DOI Listing

Auditory versus visual neuroscience-informed cognitive training in schizophrenia: Effects on cognition, symptoms and quality of life.

Schizophr Res 2020 May 21. Epub 2020 May 21.

Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil. Electronic address:

Background: Cognitive impairments are related to deficits in primary auditory and visual sensory processes in schizophrenia. These impairments can be remediated by neuroscience-informed computerized cognitive trainings that target auditory and visual processes. However, it is not clear which modality results in greater improvements in cognition, symptoms and quality of life. Read More

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http://dx.doi.org/10.1016/j.schres.2020.05.017DOI Listing

Immediate versus wait-and-gradual discontinuation in antipsychotic switching: A meta-analysis.

J Psychopharmacol 2020 May 25:269881120922964. Epub 2020 May 25.

Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Canada.

Introduction: In two previous meta-analyses of randomized controlled trials (RCTs) examining antipsychotic switching strategies in patients with schizophrenia, we showed no significant differences in any clinical outcomes between immediate versus gradual and gradual versus wait-and-gradual discontinuation of the pre-switch antipsychotic. In this report, we compared immediate versus wait-and-gradual antipsychotic discontinuation.

Methods: We identified five RCTs examining immediate versus wait-and-gradual discontinuation of the pre-switch antipsychotic in antipsychotic switching involving patients with schizophrenia. Read More

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http://dx.doi.org/10.1177/0269881120922964DOI Listing

Psychometric properties of the General Functioning Questionnaire (GFQ-58) used for screening for symptoms of psychopathology and overall level of functioning.

Psychiatr Pol 2020 Feb 29;54(1):83-100. Epub 2020 Feb 29.

Wydział Psychologii, Uniwersytet Warszawski.

Objectives: Measuring severity of psychopathological symptoms using self-assessment questionnaires is important for clinical and scientific research. However, there is no widely-available Polish tool which measures both overall functioning and severity of a broad spectrum of psychopathological symptoms. This paper describesthe designing of such a tool -the General Functioning Questionnaire (GFQ-58). Read More

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http://dx.doi.org/10.12740/PP/99564DOI Listing
February 2020

Cognitive markers related to long-term remission status in Schizophrenia Spectrum Disorders.

Psychiatry Res 2020 May 15;289:113035. Epub 2020 May 15.

Department of Psychiatry, NU Health Care Hospital, Trollhättan, Sweden; Department of Psychology, Karlstad University, Karlstad, Sweden.

Cognitive impairment is an established feature of schizophrenia. From a cross-sectional perspective, studies have revealed associations between cognition and remission. Few studies have examined this relationship longitudinally. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113035DOI Listing

Reduced blood agmatine level in early-onset schizophrenia.

Schizophr Res 2020 May 20. Epub 2020 May 20.

Neuropsychopharmacology Application and Research Center (NPARC), Üsküdar University, İstanbul, Turkey.

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http://dx.doi.org/10.1016/j.schres.2020.05.006DOI Listing

Generation of four postmortem dura-derived iPS cell lines from four control individuals with genotypic and brain-region-specific transcriptomic data available through the BrainSEQ consortium.

Stem Cell Res 2020 Apr 20;46:101806. Epub 2020 Apr 20.

Lieber Institute for Brain Development, Baltimore, Maryland, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. Electronic address:

In this study, we established induced pluripotent stem (iPS) cell lines from postmortem dura-derived fibroblasts of four control individuals with low polygenic risk score for psychiatric disorders including schizophrenia and bipolar disorder. The fibroblasts were reprogrammed into iPS cells using episomal vectors carrying OCT3/4, SOX2, KLF4, L-Myc, LIN28 and shRNA-p53. All iPS cell lines showed the same genotype with parental postmortem brain tissues, expressed pluripotency markers, and exhibited the differentiation potency into three embryonic germ layers. Read More

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http://dx.doi.org/10.1016/j.scr.2020.101806DOI Listing

Morita therapy for schizophrenia: An updated meta-analysis.

Asian J Psychiatr 2020 May 16;53:102169. Epub 2020 May 16.

School of Nursing, Jilin University, NO.965 Xinjiang Street, Changchun, 130021, China; Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China. Electronic address:

Morita therapy was developed for common mental problems, and our aim was to evaluate the clinical effect of Morita therapy on schizophrenia. The literature was searched in 10 databases, namely, PubMed, Chinese National Knowledge Infrastructure (CNKI), Sinomed, Wanfang, Cochrane Library, UpToDate, Web of Science, Medline, PsycINFO and Embase, from inception to September 4, 2019. Random-effects models were used. Read More

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http://dx.doi.org/10.1016/j.ajp.2020.102169DOI Listing

Nonsocial cognitive underpinnings of theory of mind in schizophrenia.

Psychiatry Res 2020 May 15;289:113055. Epub 2020 May 15.

Norwegian Centre for Mental Disorders Research, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address:

Social cognition is a mediator between nonsocial cognition and functional outcome in schizophrenia. However, the relationship between specific nonsocial cognitive and social cognitive domains is less clear. The aim of this study was to investigate which specific nonsocial cognitive domains best predict theory of mind (ToM) performance in schizophrenia. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113055DOI Listing

Genome-wide association study of aggression and violence in schizophrenia.

Neurosci Lett 2020 May 20:135061. Epub 2020 May 20.

Centre for Addiction and Mental Health, Canada. Electronic address:

Schizophrenia patients are at higher risk of engaging in violent behavior than the general population. Schizophrenia is also regarded as a highly heritable disorder. This study aims to analyze genome-wide the effect of SNPs on violence in schizophrenia. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135061DOI Listing

Association between serum folate levels and schizophrenia based on gender.

Psychiatry Clin Neurosci 2020 May 23. Epub 2020 May 23.

Department of Psychiatry, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, Japan.

Aim: Gender differences in serum folate concentrations are well known, but no studies have investigated the association between serum folate levels and schizophrenia based on gender. In this study in a Japanese population, we examined the difference in serum folate levels between patients with schizophrenia and non-psychiatric controls stratified by gender. The relationships between serum folate levels, plasma total homocysteine (tHcy) and serum vitamin B6 (pyridoxal) levels were also examined using data from our previous studies. Read More

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http://dx.doi.org/10.1111/pcn.13074DOI Listing

"Schizophrenia; a review on promising drug delivery systems".

Curr Pharm Des 2020 May 23. Epub 2020 May 23.

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul. Turkey.

Background: Schizophrenia belongs to mental illnesses affecting 1% of the worldwide population. Its therapy is still unmet; thus, researchers aimed to develop new pharmacological molecules which can improve its management.

Methods: Moreover, the current typical and atypical antipsychotics should be formulated in more efficacious systems that can deliver the drug in the brain with as few side effects as possible. Read More

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http://dx.doi.org/10.2174/1381612826666200523173102DOI Listing

Hungarian Psychiatrists' Recognition, Knowledge, and Treatment of Catatonia.

Psychiatr Q 2020 May 22. Epub 2020 May 22.

Centre for Psychiatry and Addiction Medicine -Jahn Ferenc South-Pest Hospital, Budapest, Hungary.

DSM-5 introduced a number of modifications to the catatonic syndrome, which is now closer to Kahlbaum's original concept. The aim of the present study was to assess residents' and qualified psychiatrists' knowledge, experience and views about the treatment of catatonia in acute psychiatric care in Budapest, Hungary. Authors approached all psychiatric units that provide acute psychiatric care (N = 11) in Budapest and invited all psychiatrists and residents, who consented, to participate in the survey, completing a 13 items questionnaire. Read More

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http://dx.doi.org/10.1007/s11126-020-09748-zDOI Listing

What have antidepressants been tested for? A systematic review.

Int J Risk Saf Med 2020 May 21. Epub 2020 May 21.

Institute for Scientific Freedom, Copenhagen, Denmark.

Background: Antidepressants are much used and have been tested for many conditions.

Objective: To investigate the type of diagnoses in placebo-controlled trials apart from depression and anxiety.

Methods: This was a systematic review. Read More

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http://dx.doi.org/10.3233/JRS-200006DOI Listing

Iron homeostasis alterations and risk for akathisia in patients treated with antipsychotics: A systematic review and meta-analysis of cross-sectional studies.

Eur Neuropsychopharmacol 2020 May 19. Epub 2020 May 19.

The Zucker Hillside Hospital, Department of Psychiatry, Northwell Health, Glen Oaks, NY 11004, USA; The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Department of Psychiatry and Molecular Medicine, Hempstead, New York, USA; The Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, New York, USA.

Iron homeostasis may be implicated in the pathophysiology of antipsychotic-related akathisia. We performed a systematic review in six databases from database inception until 03/2020, conducting a meta-analysis of studies investigating iron metabolism in antipsychotic-treated patients with versus without akathisia. Using a fixed- and a random-effects model, standardized mean difference (SMD) was estimated for levels of iron, ferritin, transferrin and total iron-binding capacity. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2020.04.001DOI Listing

Shedding Light on the Dark Side of the Microglia.

ASN Neuro 2020 Jan-Dec;12:1759091420925335

Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval.

Microglia, the resident immune cells of the central nervous system, are not a homogeneous population; their morphology, molecular profile, and even their ultrastructure greatly vary from one cell to another. Recent advances in the field of neuroimmunology have helped to demystify the enigma that currently surrounds microglial heterogeneity. Indeed, numerous microglial subtypes have been discovered such as the disease-associated microglia, neurodegenerative phenotype, and Cd11c-positive developmental population. Read More

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http://dx.doi.org/10.1177/1759091420925335DOI Listing