62,851 results match your criteria Schizoaffective Disorder


A Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions.

Genes (Basel) 2019 Feb 13;10(2). Epub 2019 Feb 13.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.

Post-traumatic stress disorder (PTSD) is an acquired psychiatric disorder with functionally impairing physiological and psychological symptoms following a traumatic exposure. Genetic, epigenetic, and environmental factors act together to determine both an individual's susceptibility to PTSD and its clinical phenotype. In this literature review, we briefly review the candidate genes that have been implicated in the development and severity of the PTSD phenotype. Read More

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http://dx.doi.org/10.3390/genes10020140DOI Listing
February 2019

Fine-mapping scan of bipolar disorder susceptibility loci in Latino pedigrees.

Am J Med Genet B Neuropsychiatr Genet 2019 Feb 19. Epub 2019 Feb 19.

Center of Emphasis in Neurosciences, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas.

We previously identified bipolar disorder (BD) susceptibility loci on 8q24, 14q32, and 2q12-14 in a genome-wide nonparametric linkage screen in a Latino cohort. We now perform a fine mapping analysis using a dense map of additional SNPs to identify BD susceptibility genes within these regions. One thousand nine hundred and thirty-eight individuals with Latino ancestry (880 individuals with BD Type I or Schizoaffective, Bipolar Type) from 416 Latino pedigrees from the United States, Mexico, Costa Rica, and Guatemala were genotyped with 3,074 SNPs to provide dense coverage of the 8q24 (11. Read More

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http://dx.doi.org/10.1002/ajmg.b.32715DOI Listing
February 2019

[Inverse correlation between psychotic disorders and tumor development].

Vertex 2018 Jul;XXIX(140):279-284

Servicio de Psiquiatría, Hospital Universitario Fundación Alcorcón, Madrid.

Patients suffering from psychotic disorders have an increased morbidity compared with control population. Moreover, these patients are prone to habits such as smoking or obesity, which in fact are risk factors for developing neoplasias.

Objective: The current study is aimed to determine the prevalence of oncologic processes (lung, colon and prostate cancer) among patients diagnosed with psychotic disorders. Read More

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Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls.

J Psychiatr Res 2019 Feb 8;111:169-185. Epub 2019 Feb 8.

Brain Research Center, Ankara University, Ankara, Turkey. Electronic address:

Compared to the general population, individuals diagnosed with Schizophrenia (SCZ) experience a higher frequency and an earlier onset of chronic medical disorders, resulting in a reduction in life expectancy by an average of 15-25 years. Recently, it has been hypothesized that SCZ is a syndrome of accelerated aging. Childhood adversity was also associated with the pathogenesis and course of SCZ. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.022DOI Listing
February 2019

Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating.

J Ethnopharmacol 2019 Feb 15. Epub 2019 Feb 15.

Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Germany; Center of Behavioral Brain Sciences, Otto-von-Guericke University Magdeburg, Germany. Electronic address:

Ethnopharmacological Relevance: The plant arctic root (Rhodiola rosea, L.) is growing in northern regions of Europe, Asia and North America. Extracts of R. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.031DOI Listing
February 2019

Prevalence of Hoarding in an Adult Inpatient Population and Its Association With Axis I Diagnoses.

Am J Geriatr Psychiatry 2018 Dec 28. Epub 2018 Dec 28.

Department of Psychiatry (AB, NG, SP, TJ), Maimonides Medical Center, Brooklyn, NY. Electronic address:

Objective: Hoarding behavior is not limited to obsessive-compulsive disorder (OCD) alone. With the objective of highlighting the association between hoarding behavior and common psychiatric disorders, we explored its occurrence in psychiatric inpatients and co-occurrence with Axis I diagnoses.

Methods: In this prospective cohort study, we enrolled adult psychiatric inpatients by simple random sampling at an urban, community-based, academic medical center. Read More

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http://dx.doi.org/10.1016/j.jagp.2018.12.029DOI Listing
December 2018

Assessment of 3-dimensional wisdom in schizophrenia: Associations with neuropsychological functions and physical and mental health.

Schizophr Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Psychiatry, University of California San Diego, La Jolla, CA, United States; Sam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla, CA, United States; Department of Neurosciences, University of California San Diego, La Jolla, CA, United States. Electronic address:

Recent decades have seen growing empirical research in wisdom as a complex, trait-based psychological characteristic. Wisdom has been shown to possess individual and societal benefits through associations with health and well-being, but it has not yet been evaluated in people with schizophrenia (PwS). In the current study, we administered a widely used, validated 3-dimensional wisdom scale that includes three interrelated dimensions: cognitive, reflective, and affective. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.022DOI Listing
February 2019
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Early intervention for obsessive compulsive disorder: An expert consensus statement.

Eur Neuropsychopharmacol 2019 Feb 14. Epub 2019 Feb 14.

Sackler Medical School, Tel Aviv University, Chaim Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel.

Obsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI) is high (up to around 10 years in adults) and is associated with considerable suffering for the individual and their families. This consensus statement represents the views of an international group of expert clinicians, including child and adult psychiatrists, psychologists and neuroscientists, working both in high and low and middle income countries, as well as those with the experience of living with OCD. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2019.02.002DOI Listing
February 2019

Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis.

Mol Psychiatry 2019 Feb 15. Epub 2019 Feb 15.

National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust, and Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.

The neurobiological mechanisms underlying the association between cannabis use and acute or long-lasting psychosis are not completely understood. While some evidence suggests altered striatal dopamine may underlie the association, direct evidence that cannabis use affects either acute or chronic striatal dopamine is inconclusive. In contrast, pre-clinical research suggests that cannabis may affect dopamine via modulation of glutamate signaling. Read More

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http://dx.doi.org/10.1038/s41380-019-0374-8DOI Listing
February 2019

Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.

Eur Neuropsychopharmacol 2019 Feb 12. Epub 2019 Feb 12.

Barcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st., Barcelona, Catalunya, Spain. Electronic address:

Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder (BD) and/or Schizoaffective Disorder (SAD). We searched six databases from inception to 28-March-2018, using the strategy: long-acting antipsychotics AND (bipolar disorder OR schizoaffective disorder OR mania OR manic OR bipolar depression). Read More

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http://dx.doi.org/10.1016/j.euroneuro.2019.02.003DOI Listing
February 2019

Illness representations among parents of children and adults with serious mental disorders: A systematic review and theoretical model.

Eur Psychiatry 2019 Feb 12;58:27-37. Epub 2019 Feb 12.

GGZ Drenthe Mental Health Institute, Department of Psychotic Disorders, Assen, the Netherlands; Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, the Netherlands.

Objective: Cognitive representations of an illness have an important impact on psychological outcomes. The current systematic review explored 1) the characteristics of illness representations held by parents of children and adults with serious mental illness (SMI), and 2) the associations of these representations with both parents' and patients' psychological outcomes.

Method: PSYINFO and PUBMED were screened for eligible studies published between January 2000 and August 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09249338193003
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http://dx.doi.org/10.1016/j.eurpsy.2019.02.001DOI Listing
February 2019
4 Reads

Psychotic-Like Experiences in Offspring of Parents With Bipolar Disorder and Community Controls: A Longitudinal Study.

J Am Acad Child Adolesc Psychiatry 2018 Nov 2. Epub 2018 Nov 2.

University of Pittsburgh, PA.

Objective: To compare the prevalence and risk factors associated with Psychotic-Like-Experiences (PLE) in offspring of parents with bipolar disorder (BP) and offspring of community control parents.

Method: Delusional and hallucinatory subclinical psychotic experiences were evaluated at intake and longitudinally in a cohort study of 390 offspring of BP parents and 247 offspring of control parents aged 6-18 years old. The sample was followed up every 2. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.09.440DOI Listing
November 2018

Constructing the Immune Signature of Schizophrenia for Clinical Use and Research; An Integrative Review Translating Descriptives Into Diagnostics.

Front Psychiatry 2018 31;9:753. Epub 2019 Jan 31.

Psychiatric Division, Haukeland University Hospital, Bergen, Norway.

Schizophrenia is considered a syndrome comprised by several disease phenotypes, covering a range of underlying pathologies. One of these disease mechanisms seems to involve immune dysregulation and neuroinflammation. While the current dopamine receptor-blocking antipsychotic drugs decrease psychotic symptoms and prevent relapse in the majority of patients with schizophrenia, there is a huge need to explore new treatment options that target other pathophysiological pathways. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365449PMC
January 2019

Psychodynamically Oriented Psychopharmacotherapy: Towards a Necessary Synthesis.

Front Hum Neurosci 2019 31;13:15. Epub 2019 Jan 31.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

The discovery of psychoanalysis and of psychotropic medications represent two radical events in understanding and treatment of mental suffering. The growth of both disciplines together with the awareness of the impracticality of curing mental suffering only through pharmacological molecules-the collapse of the "Great Illusion"-and the experience of psychoanalysts using psychotropic medications along with depth psychotherapeutic treatment, have led to integrated therapies which are arguably more effective than either modality alone. The authors review studies on the role of pharmacotherapy with psychoanalysis, and the role of the analyst as the prescriber. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365422PMC
January 2019

The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data.

Lancet Psychiatry 2019 Feb 11. Epub 2019 Feb 11.

Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; Department of Neurology, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address:

Background: Early immunotherapy administration improves outcomes in patients with N-methyl-D-aspartate receptor (NMDAR)-antibody encephalitis. As most patients with NMDAR-antibody encephalitis present to psychiatrists, the psychopathology of NMDAR-antibody encephalitis needs to be clearly defined to encourage accurate clinical identification and prompt treatment.

Methods: For this systematic review, we searched PubMed for all studies published in English between Jan 1, 2005, and Oct 7, 2017, to identify individually reported adult patients (≥18 years) who satisfied consensus criteria for definite NMDAR-antibody encephalitis. Read More

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http://dx.doi.org/10.1016/S2215-0366(19)30001-XDOI Listing
February 2019

Subtypes of treatment-resistant depression determined by a latent class analysis in a Chinese clinical population.

J Affect Disord 2019 Feb 6;249:82-89. Epub 2019 Feb 6.

Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, 600 South Wan Ping Road, Shanghai, China; CAS Center for Excellence in Brain Science and Intelligence Technology, 600 South Wan Ping Road, Shanghai, China. Electronic address:

Background: This study aimed to explore subtypes of treatment-resistant depression (TRD).

Methods: Latent class analysis (LCA) was performed on clinical and demographic data collected from 375 patients with TRD. Clinical variables were compared across subtypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183258
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http://dx.doi.org/10.1016/j.jad.2019.02.005DOI Listing
February 2019
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Brain imaging in psychiatric disorders: target or screen?

BJPsych Open 2019 Jan;5(1):e4

Consultant Neuropsychiatrist and Director, Neuropsychiatry Unit,Royal Melbourne Hospital; andMelbourne Neuropsychiatry Centre,Melbourne Health and University of Melbourne,Australia.

SummaryThere is currently debate about when a clinician should consider neuroimaging for patients with a known psychiatric illness. We consider this topic and propose a set of 'red flags' to use to aid decision-making.Declaration of interestNone. Read More

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http://dx.doi.org/10.1192/bjo.2018.79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343113PMC
January 2019

Schizophrenia and pregnancy: a national register-based follow-up study among Finnish women born between 1965 and 1980.

Arch Womens Ment Health 2019 Feb 14. Epub 2019 Feb 14.

Forensic Psychiatry, Helsinki University and Helsinki University Hospital, Psykiatriakeskus, P.O. Box 590, 00029, HUS, Finland.

To assess psychosocial and somatic risk factors related to pregnancy, and pregnancy-related complications or disorders in women with schizophrenia compared to population controls. In this register-based cohort study, we identified all Finnish women who were born in 1965-1980 and diagnosed with schizophrenia in psychiatric care before 31 December 2013. For each case, five age- and place-of-birth matched controls were randomly selected. Read More

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http://dx.doi.org/10.1007/s00737-019-0948-0DOI Listing
February 2019
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Aphasia rehabilitation based on mirror neuron theory: a randomized-block-design study of neuropsychology and functional magnetic resonance imaging.

Neural Regen Res 2019 Jun;14(6):1004-1012

Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate that hand-action observation training may lead to activation and remodeling of mirror neuron systems, which include important language centers, and may improve language function in aphasia patients. In this randomized-block-design experiment, we recruited 24 aphasia patients from, Zhongda Hospital, Southeast University, China. Read More

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http://dx.doi.org/10.4103/1673-5374.250580DOI Listing

The validation of a new online cognitive assessment tool: The MyCognition Quotient.

Int J Methods Psychiatr Res 2019 Feb 13:e1775. Epub 2019 Feb 13.

Department of Psychiatry, Amsterdam University Medical Centers (location AMC), Amsterdam, The Netherlands.

Objectives: Cognitive impairment affects many psychiatric patients, influences daily functioning, and should be an important treatment focus. Assessment of cognitive status is crucial in cognitive remediation studies. However, current test batteries have limitations. Read More

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http://dx.doi.org/10.1002/mpr.1775DOI Listing
February 2019
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3.759 Impact Factor

Two-Year Clinical and Functional Outcomes of an Asian Cohort at Ultra-High Risk of Psychosis.

Front Psychiatry 2018 25;9:758. Epub 2019 Jan 25.

Institute of Mental Health, Singapore, Singapore.

To determine the 2-year clinical and functional outcomes of an Asian cohort at ultra-high risk (UHR) of psychosis. This was a longitudinal study with a follow-up period of 2 years on 255 help-seeking adolescents and young adults at UHR of psychosis managed by a multi-disciplinary mental health team in Singapore. Clients received case management, psychosocial, and pharmacological treatment as appropriate. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362403PMC
January 2019
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Reduced auditory evoked gamma-band response and schizophrenia-like clinical symptoms under subanesthetic ketamine.

Neuropsychopharmacology 2019 Feb 6. Epub 2019 Feb 6.

Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Abnormal gamma-band oscillations (GBO) have been frequently associated with the pathophysiology of schizophrenia. GBO are modulated by glutamate, a neurotransmitter, which is continuously discussed to shape the complex symptom spectrum in schizophrenia. The current study examined the effects of ketamine, a glutamate N-methyl-D-aspartate receptor (NMDAR) antagonist, on the auditory-evoked gamma-band response (aeGBR) and psychopathological outcomes in healthy volunteers to investigate neuronal mechanisms of psychotic behavior. Read More

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http://dx.doi.org/10.1038/s41386-019-0328-5DOI Listing
February 2019

Psychosis risk is associated with decreased resting-state functional connectivity between the striatum and the default mode network.

Cogn Affect Behav Neurosci 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.

Psychosis is linked to aberrant salience or to viewing neutral stimuli as self-relevant, suggesting a possible impairment in self-relevance processing. Psychosis is also associated with increased dopamine in the dorsal striatum, especially the anterior caudate (Kegeles et al., 2010). Read More

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http://dx.doi.org/10.3758/s13415-019-00698-zDOI Listing
February 2019
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[Schizophrenia: What Non-Psychiatrist Physicians Need to Know].

Acta Med Port 2019 Feb 1;32(1):70-77. Epub 2019 Feb 1.

Serviço de Psiquiatria. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Departamento de Psiquiatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Schizophrenia is a disabling and severe mental illness that affects all social classes and racial and ethnic groups, spreading across every part of the world. It's more frequent in males and it usually manifests itself in late adolescence or early adulthood and its early detection by all clinicians is important so that there is a proper referral to specialized psychiatric care. This article intends to update the knowledge regarding the diagnosis, treatment and prognosis of schizophrenia, with an emphasis on the warning signs for a timely referral to psychiatric evaluation. Read More

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http://dx.doi.org/10.20344/amp.10768DOI Listing
February 2019
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Common Taxonomy of Traits and Symptoms: Linking Schizophrenia Symptoms, Schizotypy, and Normal Personality.

Schizophr Bull 2019 Feb 9. Epub 2019 Feb 9.

Department of Psychiatry, Stony Brook University, Stony Brook, NY.

The associations among normal personality and many mental disorders are well established, but it remains unclear whether and how symptoms of schizophrenia and schizotypal traits align with the personality taxonomy. This study examined the joint factor structure of normal personality, schizotypy, and schizophrenia symptoms in people with psychotic disorders (n = 288) and never-psychotic adults (n = 257) in the Suffolk County Mental Health Project. First, we evaluated the structure of schizotypal (positive schizotypy, negative schizotypy, and mistrust) and normal traits. Read More

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http://dx.doi.org/10.1093/schbul/sbz005DOI Listing
February 2019
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Psychometric properties of the Spanish version of the Involvement Evaluation Questionnaire in caregivers of patients with borderline personality disorders.

Clin Psychol Psychother 2019 Feb 12. Epub 2019 Feb 12.

Facultad de Psicología, Universidad de Valencia, España.

The Involvement Evaluation Questionnaire (IEQ) was created to evaluate the caregiver's experience of burden and the consequences of providing care to people with psychotic disorders. To date, the IEQ has not been validated with caregivers of people diagnosed with Borderline Personality Disorder (BPD). The main objective of the study was to confirm the psychometric properties and factorial structure of the Spanish version of the IEQ in 151 caregivers of people with BPD, with an average age of 54. Read More

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http://dx.doi.org/10.1002/cpp.2359DOI Listing
February 2019
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Adjunctive telmisartan treatment on body metabolism in clozapine or olanzapine treated patients with schizophrenia: a randomized, double blind, placebo controlled trial.

Psychopharmacology (Berl) 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychiatry, Boston University/Boston Medical Center, Boston, MA, USA.

Objective: This study examined the effect of adjunctive telmisartan on body metabolism in clozapine- or olanzapine-treated patients with schizophrenia.

Method: Each subject had been on stable dose of olanzapine or clozapine for at least 1 month. In a 12-week randomized, double-blind, placebo-controlled study, subjects received either telmisartan (80 mg once per day) or placebo. Read More

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http://dx.doi.org/10.1007/s00213-019-5181-zDOI Listing
February 2019
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Understanding the schizophrenia phenotype in the first patient with the full SCN2A phenotypic spectrum.

Psychiatr Genet 2019 Feb 6. Epub 2019 Feb 6.

The Fred A. Litwin Family Centre in Genetic Medicine, University Health Network and Mount Sinai Hospital.

The sodium voltage-gated channel α subunit 2 (SCN2A) gene encodes a subunit of sodium voltage-gated channels expressed primarily in the central nervous system that are responsible for action potential initiation and propagation in excitable cells. SCN2A mutations underlie a spectrum of distinct phenotypes, including seizure disorders, neurodevelopmental disorders, and rarer instances of episodic ataxia and schizophrenia. We report on a 38-year-old patient with adult-onset psychotic symptoms on a background of infantile-onset seizures, autistic features and episodic ataxia. Read More

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http://dx.doi.org/10.1097/YPG.0000000000000219DOI Listing
February 2019
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Accelerated Aging of Functional Brain Networks Supporting Cognitive Function in Psychotic Disorders.

Biol Psychiatry 2019 Jan 4. Epub 2019 Jan 4.

Department of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee.

Background: Across networks, connectivity within the frontoparietal network (FPN) and cingulo-opercular network (CON) exhibits reductions earliest during healthy aging, contributing to cognitive impairment. Individuals with psychotic disorders demonstrate evidence of accelerated aging across multiple biological systems. By leveraging a large sample of patients with psychosis from early to chronic illness stages, this study sought to determine whether the CON and FPN exhibit evidence of accelerated aging in psychotic disorders, confirm associations between network efficiency and cognition, and determine whether reduced network efficiency is observed in early-stage psychosis. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.016DOI Listing
January 2019
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Emotion regulation across the psychosis continuum.

Dev Psychopathol 2019 Feb 11:1-9. Epub 2019 Feb 11.

Department of Psychology,University of Georgia,Athens, GA,USA.

Emotion regulation dysfunction is characteristic of psychotic disorders, but little is known about how the use of specific types of emotion regulation strategies differs across phases of psychotic illness. This information is vital for understanding factors contributing to psychosis vulnerability states and developing targeted treatments. Three studies were conducted to examine emotion regulation across phases of psychosis, which included (a) adolescent community members with psychotic-like experiences (PLEs; n = 262) and adolescents without PLEs (n = 1,226); (b) adolescents who met clinical high-risk criteria for a prodromal syndrome (n = 29) and healthy controls (n = 29); and (c) outpatients diagnosed with schizophrenia or schizoaffective disorder (SZ; n = 61) and healthy controls (n = 67). Read More

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http://dx.doi.org/10.1017/S0954579418001682DOI Listing
February 2019
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Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia.

Behav Brain Res 2019 Feb 7. Epub 2019 Feb 7.

School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China; Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, Shaanxi, China; Institute of Automation, Chinese Academy of Sciences, Beijing, China. Electronic address:

Catechol-O-methyltransferase (COMT) gene variants have been reported to be implicated in the pathogenesis of psychotic symptoms in schizophrenia, especially in negative symptoms. These symptoms including apathy, blunted affect, social withdrawal and motor retardation. Neuroimaging studies suggested that negative symptoms appear to be associated with impaired activities of the prefrontal cortex in particular the dorsolateral prefrontal cortex (DLPFC). Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.012DOI Listing
February 2019
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3.028 Impact Factor

Family networks during migration and risk of non-affective psychosis: A population-based cohort study.

Schizophr Res 2019 Feb 7. Epub 2019 Feb 7.

Division of Psychiatry, UCL, London, United Kingdom.

Objective: The determinants of increased psychosis risk among immigrants remain unclear. Given ethnic density may be protective, we investigated whether the presence of immediate family, or "family networks", at time of immigration was associated with risk of non-affective psychosis.

Methods: We followed a cohort of migrants (n = 838,717) to Sweden, born 1968-1997, from their 14 birthday, or earliest immigration thereafter, until diagnosis of non-affective psychosis (ICD-9/ICD-10), emigration, death, or 2011. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.044DOI Listing
February 2019
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Meta-Review: Network Meta-Analyses in Child and Adolescent Psychiatry.

J Am Acad Child Adolesc Psychiatry 2019 Feb 16;58(2):167-179. Epub 2018 Oct 16.

Warneford Hospital and Oxford Health NHS Foundation Trust, University of Oxford, UK.

Objective: Network meta-analyses (NMAs) are gaining traction as the preferred method for evidence synthesis of intervention studies. This review aimed to summarize the basics of NMAs and conduct a meta-review of available NMAs on the treatment of child and adolescent psychiatric disorders by appraising their quality.

Method: PubMed (Medline), PsycInfo, Embase, Ovid Medline, and Web of Knowledge were systematically searched (last update January 9, 2018). Read More

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http://dx.doi.org/10.1016/j.jaac.2018.07.891DOI Listing
February 2019
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Competency Restoration for Adult Defendants in Different Treatment Environments.

J Am Acad Psychiatry Law 2019 Feb 8. Epub 2019 Feb 8.

Dr. Danzer is a licensed psychologist at Florida State Hospital, Tallahassee, FL. Dr. Wheeler is a former Director of the Forensic Evaluation Department at Central State Hospital and currently in private practice at Bay Forensic Psychology, Petersburg, VA. Dr. Alexander is a Clinical Assistant Professor, Graduate School of Professional Psychology, Denver Forensic Institute of Research, Service, and Training, University of Denver, Denver, CO. Dr. Wasser is an Assistant Professor of Psychiatry, Yale University School of Medicine, New Haven, CT.

The optimization of trial competency restoration is a topic of growing interest and controversy in the fields of forensics, psychology, criminal law, and public policy. Research has established that adult defendants who have severe psychotic disorders and cognitive impairments are more likely than defendants without these conditions to be found incompetent to stand trial and are less likely to be restored to competency thereafter. Research has also identified some of the benefits of attempting restoration in hospitals, jails, or outpatient settings for defendants with different diagnoses or levels of cognitive functioning. Read More

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http://dx.doi.org/10.29158/JAAPL.003819-19DOI Listing
February 2019
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How to help homeless youth suffering from first episode psychosis and substance use disorders? The creation of a new intensive outreach intervention team.

Psychiatry Res 2019 Jan 27;273:603-612. Epub 2019 Jan 27.

Department of Psychiatry, Université de Montréal, 2900 Boulevard Edouard Montpetit, Montréal, QC, Canada, QC H3T 1J4; Centre hospitalier de l'Université de Montréal (CHUM) - 1000, rue St-Denis, Montréal, QC, Canada, H2X 0C1; Centre de recherche du CHUM, 900, rue St-Denis, Montréal, QC, Canada, H2X 0A9. Electronic address:

In Canada, about 6,000 youth are homeless every night, many of whom suffer from addiction and psychotic disorders. To facilitate the exit out of homelessness, access to care and to improve psychosis and addiction outcomes, a new intensive outreach intervention team (EQIIP SOL) was created in Montreal (2012). It offers intensive outreach services dedicated to homeless youth suffering from first episode psychosis and addiction (HYFEPA) in addition to an early psychosis intervention service (EIS) in collaboration with the Addiction Psychiatry Unit. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.01.076DOI Listing
January 2019
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Clinical and electroencephalographic correlates of psychiatric features in children with frontal lobe epilepsy.

Epilepsy Behav 2019 Feb 4;92:283-289. Epub 2019 Feb 4.

Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy. Electronic address:

Background And Objective: Frontal lobe epilepsy (FLE) is often associated with psychiatric features, although the factors predisposing to the concurrence of these conditions have yet to be determined, especially in younger children. We aimed at defining possible clinical and electroencephalography (EEG) features that may enhance the psychiatric risk in pediatric FLE.

Method: We performed a structured psychiatric assessment of 59 children with FLE, using both categorical and dimensional approaches, correlated psychopathology with epilepsy data, and cognitive development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183070
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http://dx.doi.org/10.1016/j.yebeh.2019.01.008DOI Listing
February 2019
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Pathological Narcissism: A Study of Burden on Partners and Family.

J Pers Disord 2019 Feb 7:1-15. Epub 2019 Feb 7.

Illawarra Health and Medical Research Institute and School of Psychology, University of Wollongong, Australia.

Pathological narcissism is characterized by impaired interpersonal functioning, but few studies have examined the impact of the disorder on those living in a close relationship. Participants (N = 683; comprising romantic partners [77.8%], mothers [8. Read More

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http://dx.doi.org/10.1521/pedi_2019_33_413DOI Listing
February 2019
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[The evolution of the profile of psychiatric admissions via the Unified Health System in Minas Gerais, Brazil, 2001-2013].

Cien Saude Colet 2019 Feb;24(2):659-668

Fundação Hospitalar do Estado de Minas Gerais. Belo Horizonte MG Brasil.

The scope of this article is to analyze the evolution of the profile of psychiatric admissions via the Unified Health System in psychiatric hospitals of the State of Minas Gerais, Brazil, between 2001 and 2013. Data were obtained from the Information Technology Department of the Unified Health System. The analyses of trends were conducted by regression procedures, in which the independent variable was the year, and the dependent variables were the patients (sex, age, diagnosis) and admission characteristics (city, hospital administrative status, length of internment). Read More

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http://dx.doi.org/10.1590/1413-81232018242.14652017DOI Listing
February 2019
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Association of Fetal Growth With General and Specific Mental Health Conditions.

JAMA Psychiatry 2019 Feb 6. Epub 2019 Feb 6.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Importance: It is unclear if the associations between fetal growth and later mental health conditions remain after controlling for familial factors and psychiatric comorbidity.

Objective: To examine the associations between fetal growth and general and specific mental health conditions, controlling for familial factors.

Design, Setting, And Participants: This register-based study conducted in Sweden analyzed 546 894 pairs of full siblings born between January 1, 1973, and December 31, 1998. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4342DOI Listing
February 2019
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Care-giving by people with psychotic disorders in the second Australian prevalence study of psychosis.

Health Soc Care Community 2019 Feb 5. Epub 2019 Feb 5.

Department of Psychiatry, University of Melbourne and North Western Mental Health, Melbourne, Vic., Australia.

Increasing numbers of people living with psychosis are providing care for others, although the associated benefits and impacts are poorly understood. This innovative quantitative study investigated this life role using a population-based framework aiming to compare the mental health and functioning of those providing care to and/or receiving care from others. Care-giving provided by people with psychosis was examined using data from the second Australian prevalence survey of psychosis. Read More

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http://dx.doi.org/10.1111/hsc.12721DOI Listing
February 2019
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Polypharmacy Leading to Priapism in HIV Patient with Schizoaffective Disorder: A CYP450 Cascade.

Case Rep Psychiatry 2019 3;2019:4562065. Epub 2019 Jan 3.

Southern Illinois University Child Psychiatry, P.O. Box 19674, Springfield, IL 62794, USA.

With increasing trend of polypharmacy, there are higher chances of drug-drug interactions leading to adverse effects, especially in psychiatric patients with co-morbid chronic medical problems. This case demonstrates a schizoaffective 30-year-old male on highly active antiretroviral therapy (HAART) who reported an incident of priapism potentially caused by an interaction between previously prescribed atypical antipsychotic, trazodone, norepinephrine dopamine reuptake inhibitor (NDRI), HAART, and newly added selective serotonin reuptake inhibitor (SSRI). This case emphasizes obtaining careful medication history, understanding cytochrome P450 (CYP450) enzyme and its subtypes, and discouraging polypharmacy. Read More

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http://dx.doi.org/10.1155/2019/4562065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335676PMC
January 2019
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Genetic Variations of (rs947267 and rs3918342) and Genes (rs165599 and rs4680) in Schizophrenia and Bipolar I Disorder.

Basic Clin Neurosci 2018 Nov-Dec;9(6):429-438. Epub 2018 Nov 1.

Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Introduction: Genetic and environmental factors are involved in the incidence of schizophrenia and bipolar disorder. Many reports confirm that several common genes are connected with these two psychotic disorders. Several neurotransmitters may be involved in the molecular mechanisms of schizophrenia and bipolar disorder. Read More

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http://dx.doi.org/10.32598/bcn.9.6.429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359688PMC
November 2018
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The genomics of major psychiatric disorders in a large pedigree from Northern Sweden.

Transl Psychiatry 2019 Feb 4;9(1):60. Epub 2019 Feb 4.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Read More

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http://dx.doi.org/10.1038/s41398-019-0414-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362018PMC
February 2019
1 Read
4.360 Impact Factor

What is the optimal neuropsychological test battery for schizophrenia in China?

Schizophr Res 2019 Feb 1. Epub 2019 Feb 1.

Peking University Sixth Hospital, Beijing, China; Peking University Institute of Mental Health, Beijing, China; NHC Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China; The National Clinical Research Center for Mental Health Disorders (Peking University Sixth Hospital), Beijing, China. Electronic address:

Background: The MATRICS consensus cognitive battery (MCCB) has been widely used to evaluate cognitive deficits in schizophrenia (SCZ), however, no study has formally examined the validity of the MCCB in Chinese SCZ. This study compared Chinese SCZ patients with healthy Chinese controls on the MCCB and some additional neurocognitive tests to determine if the Chinese MCCB is an optimal battery to assess the cognitive deficits in Chinese SCZ patients.

Method: The study enrolled and examined 230 patients met DSM-IV criteria for SCZ and 656 healthy controls matched for gender, age and education. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.034DOI Listing
February 2019
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What we have learned from the Methadone Maintenance Treatment of Dual Disorder Heroin Use Disorder patients.

Int J Environ Res Public Health 2019 Feb 3;16(3). Epub 2019 Feb 3.

Association for the Application of Neuroscientific Knowledge to Social Aims (AU-CNS), Pietrasanta, 55045 Lucca, Italy.

Mental Disorders and Heroin Use Disorder (HUD) often co-occur and constitute correlated risk factors that the authors believe are best considered from a unitary perspective. In this article we review and discuss data collected by the V.P. Read More

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http://dx.doi.org/10.3390/ijerph16030447DOI Listing
February 2019
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The Questionnaire for Psychotic Experiences: An Examination of the Validity and Reliability.

Schizophr Bull 2019 Feb;45(Supplement_1):S78-S87

Department of Neuroscience and Department of Psychiatry, University Medical Center Groningen, The Netherlands.

Psychotic experiences are prevalent across a wide variety of psychiatric, neurological, and medical conditions. Yet current assessments are often designed for one disorder, or are limited in their examination of phenomenological features; this has hindered transdiagnostic research. This article describes an examination of the validity and reliability of the English version of a new assessment, the Questionnaire for Psychotic Experiences (QPE). Read More

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http://dx.doi.org/10.1093/schbul/sby148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357974PMC
February 2019
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Hallucinations in Children and Adolescents: An Updated Review and Practical Recommendations for Clinicians.

Schizophr Bull 2019 Feb;45(Supplement_1):S5-S23

University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research center, Groningen, the Netherlands.

Hallucinations in children and adolescents are now known to occur on a continuum from healthy to psychopathology-related phenomena. Although hallucinations in young populations are mostly transient, they can cause substantial distress. Despite hallucinations being widely investigated, research so far has had limited implications for clinical practice. Read More

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http://dx.doi.org/10.1093/schbul/sby119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357982PMC
February 2019
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A symptom-based continuum of psychosis explains cognitive and real-world functional deficits better than traditional diagnoses.

Schizophr Res 2019 Jan 30. Epub 2019 Jan 30.

The Mind Research Network/Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA; Department of Psychology, University of New Mexico, 2001 Redondo S Dr., Albuquerque, NM 87106, USA; Department of Psychiatry, University of New Mexico School of Medicine, MSC09 5030, 1 University of New Mexico, Albuquerque, NM 87131, USA; Department of Neurology, University of New Mexico School of Medicine, MSC10 5620, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address:

Background: Patients with psychotic spectrum disorders share overlapping clinical/biological features, making it often difficult to separate them into a discrete nosology (i.e., Diagnostic and Statistical Manual of Mental Disorders [DSM]). Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.024DOI Listing
January 2019
2 Reads