Am J Psychiatry 2021 Jun 22:appiajp202020121686. Epub 2021 Jun 22.
Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark (Brikell, Wimberley, Albiñana, Pedersen, Vilhjálmsson, Agerbo, Demontis, Børglum, Schork, LaBianca, Werge, Mors, Hougaard, Mortensen, Dalsgaard); National Center for Register-Based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark (Brikell, Wimberley, Albiñana, Pedersen, Vilhjálmsson, Agerbo, Mortensen, Dalsgaard); Center for Integrated Register-Based Research (CIRRAU), Aarhus University, Aarhus, Denmark (Wimberley, Agerbo, Mortensen, Dalsgaard); Department of Biomedicine and Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark (Demontis, Børglum); Center for Genomics and Personalized Medicine, Central Region Denmark and Aarhus University, Aarhus, Denmark (Demontis, Børglum); Neurogenomics Division, Translational Genomics Research Institute, Phoenix (Schork); Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen (Schork, LaBianca, Werge); Department of Clinical Medicine and Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen (Werge); Psychosis Research Unit, Aarhus University Hospital, Psychiatry, Aarhus, Denmark (Mors); Department for Congenital Disorders, Statens Serum Institut, Copenhagen (Hougaard); Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Child and Adolescent Psychiatry, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff, U.K. (Thapar).
Objective: Stimulant medications are effective for treating attention deficit hyperactivity disorder (ADHD), yet discontinuation and switch to nonstimulant ADHD medications are common. This study aimed to identify genetic, clinical, and sociodemographic factors influencing stimulant treatment initiation, discontinuation, and switch to nonstimulants in individuals with ADHD.
Methods: The authors obtained genetic and national register data for 9,133 individuals with ADHD from the Danish iPSYCH2012 sample and defined stimulant treatment initiation, discontinuation, and switch from prescriptions. Read More