66,812 results match your criteria Schizoaffective Disorder


Variants and expression changes in PPAR-encoding genes presented no significant association with overall schizophrenia cases.

Biosci Rep 2020 Jul 9. Epub 2020 Jul 9.

First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China.

A few studies suggested the contribution of PPARs to the etiology of schizophrenia (SCZ). However, it is still not clear whether PPAR genes have a direct association with SCZ. The potential linkage between SCZ and the variants within PPAR encoding genes (PPARA, PPARD, and PPARG) was tested in a large cohort Genome-wide association study (GWAS) study. Read More

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http://dx.doi.org/10.1042/BSR20201083DOI Listing

[Importance of electroconvulsive therapy (ECT) in forensic psychiatry].

Nervenarzt 2020 Jul 8. Epub 2020 Jul 8.

Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Göttingen, Von-Siebold-Straße 5, 37075, Göttingen, Deutschland.

Background And Objective: Electroconvulsive therapy (ECT) is recommended in guidelines for the treatment of severe affective and psychotic disorders that also can be found in patients in forensic psychiatric commitment; however, there are no systematically collected data concerning the use of ECT in forensic psychiatry. The aim of this study was to investigate the current state and estimated need for ECT in forensic psychiatry in Germany.

Material And Methods: A questionnaire was designed consisting of questions about the current practice and estimated need for ECT in this population. Read More

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http://dx.doi.org/10.1007/s00115-020-00947-4DOI Listing

The multiple roles of deubiquitinases in liver cancer.

Am J Cancer Res 2020 1;10(6):1647-1657. Epub 2020 Jun 1.

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine Shanghai, China.

Primary liver cancer ranks the second leading cause of death associated with cancer in the world and therefore a major public health challenge. The mortality rates of liver cancer has been increasing during the past decades with the reality that the alternative therapeutic drugs are not available. Although growing numbers of proteins involved in liver cancer progression have been identified, many of these are not suitable drug targets, which hinders the development of new drugs to cure liver cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339268PMC

Structural imaging of the retina in psychosis spectrum disorders: current status and perspectives.

Curr Opin Psychiatry 2020 Jul 6. Epub 2020 Jul 6.

Institute for Mental Health, Belgrade, Serbia and Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Purpose Of Review: Structural changes of the retina in schizophrenia and other psychotic disorders seem plausible as these conditions are accompanied by widespread morphological abnormalities of the brain. Advances in structural retinal imaging have led to the possibility of precise quantification of individual retinal layers, using optical coherence tomography (OCT) scanners.

Recent Findings: The aggregation of information related to OCT findings in schizophrenia has resulted in three metaanalyses, which are currently described. Read More

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http://dx.doi.org/10.1097/YCO.0000000000000624DOI Listing

Correlates of the Abnormal Involuntary Movement Scale in Veterans With Tardive Dyskinesia.

J Clin Psychopharmacol 2020 Jul/Aug;40(4):373-380

From the Behavioral Health Service, Corporal Michael J. Crescenz VA Medical Center.

Purpose/background: To add to limited evidence on the Abnormal Involuntary Movement Scale (AIMS) as a measure of tardive dyskinesia (TD) in clinical practice settings, the characteristics and correlates of AIMS scores were assessed.

Methods/procedures: Veterans with schizophrenia/schizoaffective, bipolar, or major depressive disorders receiving antipsychotics and at least 1 AIMS score during October 1, 2014, to September 30, 2015, were identified. Tardive dyskinesia was determined by the International Classification of Diseases, Ninth Revision, Clinical Modification, codes. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001229DOI Listing

The Conceptual Framework of Dual Disorders and Its Flaws.

J Clin Med 2020 Jul 3;9(7). Epub 2020 Jul 3.

G. De Lisio Institute of Behavioral Sciences, 56100 Pisa, Italy.

When psychiatric illness and substance use disorder coexist, the clinical approach to the patient is, unsurprisingly, awkward. This fact is due to a cultural context and, more directly, to the patient's psychiatric condition and addiction behaviors-a situation that does not favor a scientific approach. In dual disorder facilities, several types of professionals work together: counselors, social workers, psychologists, and psychiatrists. Read More

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http://dx.doi.org/10.3390/jcm9072098DOI Listing

The Psychopathology and Neuroanatomical Markers of Depression in Early Psychosis.

Schizophr Bull 2020 Jul 7. Epub 2020 Jul 7.

Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany.

Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this depression is seen primarily in a distinct subgroup, which if identified could allow targeted treatments. We hypothesize that patients with recent-onset psychosis (ROP) and comorbid depression would be identifiable by symptoms and neuroanatomical features similar to those seen in recent-onset depression (ROD). Read More

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http://dx.doi.org/10.1093/schbul/sbaa094DOI Listing

Psychotic disorders and electrocardiogram abnormalities in the acute psychiatric setting: more than the metabolic syndrome alone.

Int J Psychiatry Clin Pract 2020 Jul 7:1-3. Epub 2020 Jul 7.

South London and Maudsley NHS Foundation Trust, London, UK.

Medical comorbidity in severe mental illness (SMI) is high and often severe, accounting for reduced life expectancy in this group. We assessed the rate and degree of electrocardiogram (ECG) abnormalities in acutely unwell SMI male patients by reviewing the case notes of 50 consecutive admissions to an inpatient psychiatric unit. 82% were admitted with a psychotic disorder with a median age of 35 (range 19 - 72 years). Read More

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http://dx.doi.org/10.1080/13651501.2020.1787454DOI Listing

Time to Clinical Response in the Treatment of Early Onset Schizophrenia Spectrum Disorders Study.

J Child Adolesc Psychopharmacol 2020 Jul 1. Epub 2020 Jul 1.

Department of Psychiatry, Child Study Center, Yale University, New Haven, Connecticut, USA.

We investigated the time course of clinical response in the Treatment of Early Onset Schizophrenia Spectrum Disorders Study (TEOSS). TEOSS randomized 119 predominantly outpatient youth ages 8-19 years with schizophrenia or schizoaffective disorder to 8 weeks of treatment with molindone, risperidone, or olanzapine. We used proportional hazards regression to determine whether these three antipsychotics differed in the time until clinical response, defined as the time from treatment initiation to the point of achieving a Clinical Global Impressions-Improvement (CGI-I) scale score of 1 ("very much improved") or 2 ("much improved") that was maintained until week 8. Read More

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http://dx.doi.org/10.1089/cap.2020.0030DOI Listing

Schizotypal traits and neuropsychological performance: The role of processing speed.

Schizophr Res 2020 Jul 3. Epub 2020 Jul 3.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.

Background: Cognitive deficits, particularly in processing speed, are widely recognized as a critical feature of schizophrenia, and are also present across schizophrenia spectrum disorders. A number of important confounders, however, such as hospitalization effects and antipsychotic medication, have been shown to affect processing speed, causing debate as to the core cognitive deficits of schizophrenia. The study of individuals who are not clinically psychotic but have schizotypal traits allows investigation of cognitive deficits associated with both positive and negative schizotypy dimensions while excluding potential confounds. Read More

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http://dx.doi.org/10.1016/j.schres.2020.06.030DOI Listing

Augmenting Evidence-Based Care With a Texting Mobile Interventionist: A Pilot Randomized Controlled Trial.

Psychiatr Serv 2020 Jul 7:appips202000239. Epub 2020 Jul 7.

Department of Psychiatry and Behavioral Sciences, BRiTE Center, University of Washington, Seattle (Ben-Zeev, Buck, Meller, Hallgren); Department of Psychological and Brain Sciences, Dartmouth College, and Department of Psychiatry, Dartmouth Geisel School of Medicine, Hanover, New Hampshire (Hudenko).

Objective: This study aimed to evaluate the feasibility and clinical utility of training intensive psychiatric community care team members to serve as "mobile interventionists" who engage patients in recovery-oriented texting exchanges.

Methods: A 3-month pilot randomized controlled trial was conducted to compare the mobile interventionist approach as an add-on to assertive community treatment (ACT) versus ACT alone. Participants were 49 individuals with serious mental illness (62% with schizophrenia/schizoaffective disorder, 24% with bipolar disorder, and 14% with depression). Read More

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http://dx.doi.org/10.1176/appi.ps.202000239DOI Listing

Interpersonal Violence and Psychotic-Like Experiences: The Mediation of Ideas of Reference, Childhood Memories, and Dissociation.

Int J Environ Res Public Health 2020 Jun 25;17(12). Epub 2020 Jun 25.

Department of Psychology, University of Cadiz, Cadiz 11071, Spain.

Previous studies have demonstrated the relationship between the accumulation of situations involving interpersonal violence (IV) and psychotic-like experiences. This study explored whether IV is related to aberrant salience (AS), using a sequential mediation model that included memories of relationship with parents (submission, devaluation, and threat; Early Life Experiences Scale (ELES)), ideas of reference (IR), and dissociative symptoms (absorption and depersonalization), and whether the patient/nonpatient condition moderated this effect. The sample was made of 401 participants (including 43 patients with psychotic disorders) aged 18 to 71 years (age = 30. Read More

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http://dx.doi.org/10.3390/ijerph17124587DOI Listing

Clinical Severity and Calcium Metabolism in Patients with Bipolar Disorder.

Brain Sci 2020 Jul 1;10(7). Epub 2020 Jul 1.

Department of Psychiatry, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.

Parathyroid hormone (PTH), vitamin D and serum calcium play a key role in several physiological and pathological conditions. Vitamin D and PTH receptors are largely expressed in the central nervous system and are involved in the modulation of inflammatory responses. Few studies investigated the association between calcium homeostasis imbalance and psychiatric disorders. Read More

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http://dx.doi.org/10.3390/brainsci10070417DOI Listing

Relationship Between Clozapine Levels and Acute Inflammatory Stress.

Prim Care Companion CNS Disord 2020 Jul 2;22(4). Epub 2020 Jul 2.

Napa State Hospital, 2100 Napa Vallejo Hwy, Napa, CA 94558.

Stress-induced changes in pharmacokinetics can significantly alter the plasma levels of some drugs such as clozapine. This report describes the case of a middle-aged man with schizoaffective disorder, bipolar type who showed sustained elevation in clozapine levels 3 days after discontinuation. Before the clozapine levels were drawn, he had developed acute bacterial pneumonia and signs of acute bacterial meningitis followed by neuroleptic malignant syndrome after he received multiple doses of intravenous haloperidol for worsening psychosis and aggressive behavior. Read More

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http://dx.doi.org/10.4088/PCC.19br02586DOI Listing

Social contacts, friends and satisfaction with friendships in patients with psychotic, mood and neurotic disorders 1 year after hospitalisation: data from five European countries.

Soc Psychiatry Psychiatr Epidemiol 2020 Jul 5. Epub 2020 Jul 5.

Unit for Social and Community Psychiatry (World Health Organisation Collaborating Centre for Mental Health Services Development), Queen Mary University of London, London, UK.

Background: People with severe mental illness often struggle with social relationships, but differences among diagnostic groups are unclear. We assessed and compared objective and subjective social relationship indicators among patients with psychotic, mood and neurotic disorders one year after hospitalisation in five European countries (Belgium, Germany, Italy, Poland and United Kingdom).

Methods: The number of social contacts, including family members and friends during the previous week (Social Network Schedule), and satisfaction with the number and quality of friendships (Manchester Short Assessment of Quality of Life Quality) were assessed by face-to-face interview. Read More

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http://dx.doi.org/10.1007/s00127-020-01915-8DOI Listing

A meta-analysis comparing cognitive function across the mood/psychosis diagnostic spectrum.

Psychol Med 2020 Jun 22:1-9. Epub 2020 Jun 22.

Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.

Background: The nature and degree of cognitive impairments in schizoaffective disorder is not well established. The aim of this meta-analysis was to characterise cognitive functioning in schizoaffective disorder and compare it with cognition in schizophrenia and bipolar disorder. Schizoaffective disorder was considered both as a single category and as its two diagnostic subtypes, bipolar and depressive disorder. Read More

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http://dx.doi.org/10.1017/S0033291720002020DOI Listing

Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators.

Psychol Med 2020 Jul 6:1-22. Epub 2020 Jul 6.

King's College London, Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.

The association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and psychosis. We conducted a systematic search of the PsychINFO, Embase, Ovid, and Web of Science databases for original articles investigating the role of genetic vulnerabilities, environmental factors, psychological and psychopathological mechanisms in the association between CA and psychosis up to August 2019. Read More

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http://dx.doi.org/10.1017/S0033291720002172DOI Listing

Validation of the Bullying Scale for Adults - Results of the PRONIA-study.

J Psychiatr Res 2020 May 11;129:88-97. Epub 2020 May 11.

Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.

Background: Bullying as a specific subtype of adverse life events is a major risk factor for poor mental health. Although many questionnaires on bullying are available, so far none covers bullying retrospectively throughout school and working life. To close this gap, the Bullying Scale for Adults (BSA) was designed. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2020.04.004DOI Listing

Pharmacokinetics, Safety, and Tolerability of a 2-Month Dose Interval Regimen of the Long-Acting Injectable Antipsychotic Aripiprazole Lauroxil: Results From a 44-Week Phase I Study.

CNS Drugs 2020 Jul 3. Epub 2020 Jul 3.

CNS Network, LLC, Garden Grove, CA, USA.

Background: Aripiprazole lauroxil (AL) is a long-acting injectable antipsychotic approved for treatment of schizophrenia in adults. Approved AL doses and dosing regimens include 441 mg monthly, 662 mg monthly, and 882 mg monthly or every 6 weeks (q6wk), as well as the most recently approved dose, 1064 mg, administered every 2 months.

Objective: Pharmacokinetics, safety, and tolerability of an AL regimen with a dose interval of every 2 months (1064 mg) were compared with two other regimens available as monthly and q6wk options. Read More

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http://dx.doi.org/10.1007/s40263-020-00745-1DOI Listing

Relationships between psychiatric symptoms, functioning and personal recovery in psychosis.

Schizophr Res 2020 Jun 30. Epub 2020 Jun 30.

Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK; School of Psychological Sciences, University of Manchester, Manchester, UK.

Background: Recovery from psychosis is increasingly being viewed as a combination of symptomatic, functional, and personal recovery. Negative and depressive symptoms have been linked to community functioning, and negative affect has been linked to personal recovery. The current study examines differential associations of symptoms with functional and personal recovery, and the interaction of cognitive and emotional components of psychotic experiences in predicting recovery. Read More

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http://dx.doi.org/10.1016/j.schres.2020.06.026DOI Listing

Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report.

BMC Psychiatry 2020 Jul 3;20(1):349. Epub 2020 Jul 3.

Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Tokyo, 187-8551, Japan.

Background: Megalencephalic leukoencephalopathy with subcortical cysts (MLC), or Van der Knaap disease, is a rare spongiform leukodystrophy that is characterized by macrocephaly, progressive motor dysfunction, and mild mental retardation. It is very rare for mental illness such as psychotic disorders, affective disorders and anxiety disorders to occur in MLC.

Case Presentation: A 17-year-old boy was admitted to our hospital after he developed symptoms of depressive state with catatonia after being diagnosed as having MLC with confirmed MLC1 mutation. Read More

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http://dx.doi.org/10.1186/s12888-020-02750-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333431PMC

Psychiatric autoimmune conditions in children and adolescents: Is catatonia a severity marker?

Prog Neuropsychopharmacol Biol Psychiatry 2020 Jul 1;104:110028. Epub 2020 Jul 1.

Department of Child and Adolescent Psychiatry, Sorbonne Université, Hôpital Pitié-Salpêtrière, AP-HP, 47-83 Boulevard de l'Hôpital, 75013 Paris, France; GRC 15 PSYDEV. Troubles psychiatriques et développement. Sorbonne Université, Paris, France.

Objectives: Patients with autoimmune encephalitis (AE) are likely to exhibit an acute onset of severe psychiatric features, including psychosis and/or catatonia. Based on the high prevalence of catatonia in AE and our clinical experience, we hypothesized that catatonia might be a marker of severity requiring more aggressive treatment approaches.

Methods: To reach a sufficient number of cases with brain-autoimmune conditions, we pooled two samples (N = 58): the first from the French National Network of Rare Psychiatric diseases and the second from the largest Italian neuro-pediatrics center for encephalopathies. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.110028DOI Listing

The Impact of Anticholinergic Burden on Functional Capacity in Persons With Schizophrenia Across the Adult Life Span.

Schizophr Bull 2020 Jul 3. Epub 2020 Jul 3.

Centre for Addiction and Mental Health, Toronto, ON, Canada.

Anticholinergic burden (ACB) from medications impairs cognition in schizophrenia. Cognition is a predictor of functional capacity; however, little is known about ACB effect on functional capacity in this population. This study assesses the relationship between ACB and functional capacity across the life span in individuals with schizophrenia after controlling for ACB effect on cognition. Read More

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http://dx.doi.org/10.1093/schbul/sbaa093DOI Listing

A Latent Class Analysis of Manic and Psychotic Symptoms.

J Nerv Ment Dis 2020 Jun 29. Epub 2020 Jun 29.

Université de Paris, NeuroDiderot, Inserm.

Bipolar spectrum disorders encompass heterogeneous clinical manifestations and comorbidities. A latent class analysis (LCA) was performed in 1846 subjects who experienced an episode of abnormally elevated or irritable mood to identify homogeneous groups of subjects, based on the distribution of 11 manic and 7 psychotic symptoms. LCA identified five classes: 1) two classes with irritability and with low and high level of psychosis (respectively "irritable," 29. Read More

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http://dx.doi.org/10.1097/NMD.0000000000001193DOI Listing

Relationship between childhood trauma and social adaptation in a sample of young people attending an early intervention service for psychosis.

Rev Psiquiatr Salud Ment 2020 Jun 29. Epub 2020 Jun 29.

Departamento de Salud Mental, Parc Taulí Hospital Universitari, Sabadell, Barcelona, España; Departamento de Psiquiatría y Medicina Legal, Universitat Autónoma de Barcelona, Cerdanyola del Vallés, Barcelona, España; Instituto de Investigación e Innovación Parc Taulí (I3PT), Sabadell, Barcelona, España; Centro de Investigación en Red de Salud Mental (CIBERSAM). Electronic address:

Introduction: Childhood trauma has been associated with an increased risk of psychosis, a greater severity of psychopathological symptoms, and a worse functional prognosis in patients with psychotic disorders. The current study aims to explore the relationship between childhood trauma, psychopathology and social adaptation in a sample of young people with first episode psychosis (FEP) or at-risk mental states (ARMS).

Material And Methods: The sample included 114 young people (18-35 years old, 81 FEP and 33 ARMS) who were attending an Early Intervention Service for Psychosis. Read More

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http://dx.doi.org/10.1016/j.rpsm.2020.05.001DOI Listing

Design, synthesis and neuropharmacological evaluation of new 2,4-disubstituted-1,5-benzodiazepines as CNS active agents.

Bioorg Chem 2020 Jun 16;101:104010. Epub 2020 Jun 16.

Department of Pharmaceutical Chemistry, Rajendra Institute of Technology & Sciences, Sirsa 125055, Haryana, India; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, GT Road, Moga 142001, Punjab, India. Electronic address:

Benzodiazepines (BZDs) represent a class of privilege scaffold in the modern era of medicinal chemistry as CNS active agents and BZD based drugs are used to treat different psychotic disorders. Inspired from the therapeutic potential of BZDs as promising CNS active agents, in the present work three different series of 1,5-benzodiazepines bearing various substitutions at position 2 and 4 of the benzodiazepine core were synthesized by condensing different substituted chalcones with o-phenylenediamine in the presence of piperidine as a base catalyst. Structural characterization of title compounds was done by using various analytical techniques such as IR, NMR, elemental analysis and mass spectral data. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104010DOI Listing

Contrasting metacognitive profiles and their association with negative symptoms in groups with schizophrenia, early psychosis and depression in a Russian sample.

Psychiatry Res 2020 Jun 7;291:113177. Epub 2020 Jun 7.

Mental-health clinic №1 named after N.A. Alexeev. Zagorodnoye Shosse 2, Moscow Russia.

Research has suggested that negative symptoms in psychotic disorders may be in part fueled by deficits in metacognition or the ability to form integrated ideas about oneself and others. One limitation of this work is that it has largely come from North America and Western Europe. To further the literature, we assessed symptoms using the Positive and Negative Syndrome Scale and Metacognition using the Metacognitive Assessment Scale - Abbreviated in a sample of outpatients with prolonged schizophrenia (n = 41), early episode psychosis (n = 37) and major depression (n = 30) gathered in Moscow, Russia. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113177DOI Listing

Multiple Network Dysconnectivity in Adolescents with Psychotic Experiences: A Longitudinal Population-Based Study.

Schizophr Bull 2020 Jul 2. Epub 2020 Jul 2.

Department of Psychiatry, Smurfit Building, Royal College of Surgeons Ireland at Beaumont Hospital, Dublin, Ireland.

Abnormal functional connectivity (FC, the temporal synchronization of activation across distinct brain regions) of the default mode (DMN), salience (SN), central executive (CEN), and motor (MN) networks is well established in psychosis. However, little is known about FC in individuals, particularly adolescents, reporting subthreshold psychotic experiences (PE) and their trajectory over time. Thus, the aim of this study was to investigate the FC of these networks in adolescents with PE. Read More

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http://dx.doi.org/10.1093/schbul/sbaa056DOI Listing

Patient-level Characteristics and Inequitable Access to Inpatient Electroconvulsive Therapy for Depression: A Population-based Cross-sectional Study: Caractéristiques au niveau du patient et accès inéquitable à la thérapie électroconvulsive pour patients hospitalisés.

Can J Psychiatry 2020 Jul 2:706743720935647. Epub 2020 Jul 2.

Department of Psychiatry, University of Toronto, Ontario, Canada.

Objective: A variety of patient characteristics drive the use of electroconvulsive therapy (ECT) in depression. However, the extent to which each characteristic influences the receipt of ECT, and whether they are appropriate, is unknown. The aim of this study is to identify patient-level characteristics associated with receiving inpatient ECT for depression. Read More

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http://dx.doi.org/10.1177/0706743720935647DOI Listing

Relationship Between Illness Representations, Psychosocial Adjustment, and Treatment Outcomes in Mental Disorders: A Mini Review.

Front Psychol 2020 12;11:1167. Epub 2020 Jun 12.

Aix Marseille Univ, LPS, Aix-en-Provence, France.

Understanding and improving the psychosocial adjustments (e.g., quality of life, depression) and treatment outcomes (e. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.01167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309516PMC

Editorial: Psychosis and Personality Disorders: Do We Need Early Diagnosis for Successful Treatment?

Front Psychiatry 2020 16;11:584. Epub 2020 Jun 16.

Department of Neuroscience, School of Medicine, University of Turin, Turin, Italy.

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http://dx.doi.org/10.3389/fpsyt.2020.00584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308528PMC

The role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders.

Neuropsychopharmacology 2020 Jul 1. Epub 2020 Jul 1.

Psychosis Studies Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

There have been few studies performed to examine the pathophysiological differences between different types of psychosis, such as between delusional disorder (DD) and schizophrenia (SZ). Notably, despite the different clinical characteristics of DD and schizophrenia (SZ), antipsychotics are deemed equally effective pharmaceutical treatments for both conditions. In this context, dopamine dysregulation may be transdiagnostic of the pathophysiology of psychotic disorders such as DD and SZ. Read More

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http://dx.doi.org/10.1038/s41386-020-0740-xDOI Listing

Associations between Self-Disorders and First-Rank Symptoms: An Empirical Study.

Psychopathology 2020 Jul 1:1-8. Epub 2020 Jul 1.

Mental Health Center Copenhagen, Copenhagen, Denmark.

Background: The diagnostic weight of the first-rank symptoms was deemphasized in DSM-5 and a similar change is expected in ICD-11. This change was motivated by a lack of solid, empirical evidence of the diagnostic significance of first-rank symptoms for schizophrenia. Yet, it seems that Schneider's original concept of first-rank symptoms was overly simplified when it was introduced in DSM-III. Read More

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http://dx.doi.org/10.1159/000508189DOI Listing

Habenula deep brain stimulation for intractable schizophrenia: a pilot study.

Neurosurg Focus 2020 Jul;49(1):E9

1Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine.

Schizophrenia is a psychiatric disorder associated with significant morbidity and mortality. Although antipsychotic medications and electroconvulsive therapy can be used to manage the clinical symptoms of schizophrenia, a substantial portion (10%-30%) of patients do not clinically respond to these treatments or cannot tolerate the side effects. Recently, deep brain stimulation (DBS) has emerged as a promising safe and effective therapeutic intervention for various psychiatric disorders. Read More

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http://dx.doi.org/10.3171/2020.4.FOCUS20174DOI Listing
July 2020
2.105 Impact Factor

Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis.

Schizophr Bull 2020 Jul 1. Epub 2020 Jul 1.

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Patients with schizophrenia have a lower than average life span, largely due to the increased prevalence of cardiometabolic comorbidities. There is an unmet public health need to identify individuals with psychotic disorders who have a high risk of rapid weight gain and who are at risk of developing metabolic complications. Here, we applied mass spectrometry-based lipidomics in a prospective study comprising 48 healthy controls (CTR), 44 first-episode psychosis (FEP) patients, and 22 individuals at clinical high risk (CHR) for psychosis, from 2 study centers (Turku, Finland and London, UK). Read More

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http://dx.doi.org/10.1093/schbul/sbaa087DOI Listing

Interventions to improve medication adherence in mental health: the update of a systematic review of cost-effectiveness.

Int J Psychiatry Clin Pract 2020 Jul 1:1-12. Epub 2020 Jul 1.

Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), El Rosario, Spain.

Medication non-adherence in mental health problems has social and economic costs. The objective of the study was to review the cost-effectiveness of interventions to enhance medication adherence in patients with mental health problems. The update of a previous systematic review was performed. Read More

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http://dx.doi.org/10.1080/13651501.2020.1782434DOI Listing

Association between amphetamine-related disorders and dementia-a nationwide cohort study in Taiwan.

Ann Clin Transl Neurol 2020 Jun 30. Epub 2020 Jun 30.

Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

Objective: We have conducted a study to clarify the association between amphetamine-related disorders (ARD) and the risk of developing dementia.

Methods: This study used a retrospective cohort design by using Taiwan's National Health Research Institute Database. A random sample of 68,300 subjects between January 1, 2000, and December 31, 2015, was obtained, comprising of 17,075 patients with ARD, and 51,225 controls without ARD (1:3), matched for gender and age group. Read More

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http://dx.doi.org/10.1002/acn3.51113DOI Listing

Multi-trait analysis for genome-wide association study of five psychiatric disorders.

Transl Psychiatry 2020 Jun 30;10(1):209. Epub 2020 Jun 30.

Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, China.

We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia (SCZ) (n = 65,967), bipolar disorder (BD) (n = 41,653), autism spectrum disorder (ASD) (n = 46,350), attention deficit hyperactivity disorder (ADHD) (n = 55,374), and depression (DEP) (n = 688,809). After the meta-analysis, the number of genomic loci increased from 14 to 19 in ADHD, from 3 to 10 in ASD, from 45 to 57 in DEP, from 8 to 54 in BD, and from 64 to 87 in SCZ. We observed significant enrichment of overlapping genes among different disorders and identified a panel of cross-disorder genes. Read More

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http://dx.doi.org/10.1038/s41398-020-00902-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326916PMC

Excess tau PET ligand retention in elderly patients with major depressive disorder.

Mol Psychiatry 2020 Jul 1. Epub 2020 Jul 1.

Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Depression is one of the common psychiatric disorders in old age. Major depressive disorder (MDD) has been identified as a risk factor or prodrome for neurodegenerative dementias, suggesting neuropathological overlaps and a continuum between MDD and neurodegenerative disorders. In this study, we examined tau and amyloid-β (Aβ) accumulations in the brains of MDD and healthy controls using positron emission tomography (PET) to explore pathological substrates of this illness. Read More

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http://dx.doi.org/10.1038/s41380-020-0766-9DOI Listing

A meta-review of literature reviews assessing the capacity of patients with severe mental disorders to make decisions about their healthcare.

BMC Psychiatry 2020 Jun 30;20(1):339. Epub 2020 Jun 30.

Department of Psychiatry, Parc Sanitari Sant Joan de Déu, Barcelona, Spain.

Background: Determining the mental capacity of psychiatric patients for making healthcare related decisions is crucial in clinical practice. This meta-review of review articles comprehensively examines the current evidence on the capacity of patients with a mental illness to make medical care decisions.

Methods: Systematic review of review articles following PRISMA recommendations. Read More

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http://dx.doi.org/10.1186/s12888-020-02756-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324958PMC

Comment on Limbic Hyperactivity in Response to Emotionally Neutral Stimuli in Schizophrenia: A Neuroimaging Meta-Analysis of the Hypervigilant Mind.

Am J Psychiatry 2020 07;177(7):639-640

Department of Psychiatry, Medstar Georgetown University Hospital, Washington, DC (Rasetti); Lieber Institute for Brain Development and Maltz Research Laboratories, Baltimore (Chen, Weinberger); Department of Neurology, Department of Neuroscience, Department of Psychiatry and Behavioral Sciences, and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore (Weinberger).

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http://dx.doi.org/10.1176/appi.ajp.2020.19090973DOI Listing

A Case of Simultaneous Mania and Idiopathic Normal Pressure Hydrocephalus: Etiology or Comorbidity?

Turk Psikiyatri Derg 2019 ;30(4):290-294

Normal pressure hydrocephalus (NPH), typically associated with the triad of gait disturbance, dementia and urinary incontinence, rarely presents with symptoms of mania, depression or psychosis and psychiatric disorders may complicate the diagnosis. Few cases of NPH and psychiatric disease comorbidity have been reported so far. In most of these cases, NPH was associated with depression and psychotic symptoms. Read More

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January 2019

Case Management for Individuals with Severe Mental Illness: Outcomes of a 24-Month Practice.

Turk Psikiyatri Derg 2019 ;30(4):245-252

Objective: The aim of this study is to conduct a case management model on a group of individuals with severe mental illness (SMI) and to evaluate the outcomes during a 24-month follow up.

Method: A total of 34 patients diagnosed with schizophrenia or schizoaffective disorder with at least one exacerbation over the last year, poor treatment compliance, who were unemployed and unable to live independently and who gave consent to participate were included to the study. Case management was conducted by a medical professional in the house, schizophrenia association, hospital, and workplace of the patients by interviewing the patients, family members, and the employers of the patients, at intervals arranged according to the need of each patient. Read More

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January 2019

Psychotic symptoms in COVID-19 patients. A retrospective descriptive study.

Psychiatry Res 2020 Jun 24;291:113254. Epub 2020 Jun 24.

Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Madrid, Spain; Instituto de Investigación Sanitaria Hospital Universitario 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. Electronic address:

Psychotic symptoms have been related to other coronavirus infections. We conducted a single-centre retrospective and observational study to describe new-onset psychotic episodes in COVID-19 patients. Ten patients infected by the novel coronavirus with psychotic symptoms and no previous history of psychosis were identified by the emergency and liaison psychiatry departments. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311337PMC

Relationship between disability and pain to post-traumatic stress disorder, depression, and anxiety in patient with postoperative brachial plexus injury (BPI).

Br J Neurosurg 2020 Jun 30:1-5. Epub 2020 Jun 30.

Departement of Psychiatry, Faculty of Medicine, Dr. Soetomo General Academic Hospital, Universitas Airlangga, Surabaya, Indonesia.

Orthopedic trauma patients have the risk to experience mental disorders, including depression, anxiety, post-traumatic stress disorder (PTSD), and other mental disorders. However, studies that analyze the relationship between mental disorders in orthopedic trauma patients, especially post-operative brachial plexus injury (BPI), are still difficult to find. This study aims to evaluate the relationship between disability and pain to post-traumatic stress disorder, depression, and anxiety in patient with postoperative BPI. Read More

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http://dx.doi.org/10.1080/02688697.2020.1784846DOI Listing

The status of chemical elements in the blood plasma of children with autism spectrum disorder in Tunisia: a case-control study.

Environ Sci Pollut Res Int 2020 Jun 29. Epub 2020 Jun 29.

Department of Analytical Chemistry, University of Valencia, Valencia, Spain.

Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders defined by a deficit in social interactions and the presence of restricted and stereotypical behaviors or interests. The etiologies of autism remain mostly unknown. Many genetic and environmental factors have been suspected. Read More

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http://dx.doi.org/10.1007/s11356-020-09819-5DOI Listing

Evaluation of Self-Assessed State of Health and Vitamin D Knowledge in Emirati and International Female Students in United Arab Emirates (UAE).

Front Psychol 2020 12;11:1236. Epub 2020 Jun 12.

Department of Hygiene and Epidemiology, Department of Developmental Psychiatry, Psychotic and Geriatric Disorders, Medical University of Gdańsk, Gdańsk, Poland.

Introduction: Globally, vitamin D deficiency is one of the most common deficiencies, affecting nearly half the world's population. The objective of this survey was to assess and compare the knowledge about vitamin D and the perceived state of health in Emirati and international tourist female students in Dubai, United Arab Emirates (UAE).

Methods: This is a cross-sectional study that took place in universities in Dubai, United Arab Emirates. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.01236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303256PMC

Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms.

Front Psychiatry 2020 11;11:548. Epub 2020 Jun 11.

Child Study Center, Yale University School of Medicine, New Haven, CT, United States.

Autism spectrum disorder (ASD) and schizophrenia (SZ) are heterogenous neurodevelopmental disorders that overlap in symptom presentation. The purpose of this study was to specify overlapping symptom domains and to identify symptoms that can reliably differentiate adults with ASD (n = 53), SZ (n = 39), and typical development (TD; n = 40). All participants regardless of diagnosis were administered gold-standard diagnostic assessments of ASD and SZ characteristics including the Autism Diagnostic Observation Schedule (ADOS-2) and the Positive and Negative Syndrome Scale (PANSS). Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301837PMC