63,450 results match your criteria Schizoaffective Disorder


Hospital Stay in Synthetic Cannabinoid Users With Bipolar Disorder, Schizophrenia, or Other Psychotic Disorders Compared With Cannabis Users.

J Stud Alcohol Drugs 2019 Mar;80(2):230-235

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas.

Objective: The use of synthetic cannabinoid (SC) products has become popular in recent years, but data regarding their impact on hospital stays are limited. The impact of SC and cannabis use on hospital length of stay and doses of antipsychotics at discharge was assessed in this study.

Method: The sample consisted of inpatients with discharge diagnoses of bipolar disorder, schizophrenia, or other psychotic disorders. Read More

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Antipsychotic Adherence Intervention for Veterans over Forty with Schizophrenia: Results of a Pilot Study.

Clin Schizophr Relat Psychoses 2009 Jan;2(4):317-325

4 Veterans Administration San Diego Healthcare System and Advanced Center for Intervention and Services Research, University of California, San Diego.

This pilot study tested the feasibility, acceptability, and effect sizes of a multimodal, individual intervention designed to optimize antipsychotic medication use in patients ≥40 years of age with schizophrenia or schizoaffective disorder. We randomized forty patients into two groups: usual care (UC) versus a nine-session, manualized antipsychotic adherence intervention (AAI). The AAI attempted to improve adherence by combining three psychosocial techniques: 1) education; 2) skills training; and, 3) alliance building. Read More

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http://dx.doi.org/10.3371/CSRP.2.4.5DOI Listing
January 2009

Schizoaffective disorder comorbid with type 2 diabetes mellitus accompanied by frontotemporal atrophy and impaired cognition: A CARE compliant case report.

Medicine (Baltimore) 2019 Apr;98(16):e15292

Department of Affective Disorder, Shenzhen Kangning Hospital, Luohu District, Shenzhen, China.

Rationale: Brain atrophy coupled with impaired cognition may be a sign of dementia. However, growing evidence indicates that schizoaffective disorder (SAD) and type 2 diabetes mellitus (T2DM) play roles in the processes of frontotemporal atrophy and cognitive decline. Few cases of frontotemporal atrophy and impaired cognition have been reported in young adult patients with SAD and T2DM. Read More

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http://dx.doi.org/10.1097/MD.0000000000015292DOI Listing
April 2019
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Personalizing antipsychotic treatment: evidence and thoughts on individualized tailoring of antipsychotic dosage in the treatment of psychotic disorders.

Authors:
Lex Wunderink

Ther Adv Psychopharmacol 2019 8;9:2045125319836566. Epub 2019 Apr 8.

Department of Research and Education, Friesland Mental Health Services, Sixmastraat 2, 8932 PA Leeuwarden, Netherlands.

Effectiveness of relapse prevention with antipsychotic drugs has been robustly demonstrated. However, the drawbacks of antipsychotic maintenance treatment have prompted alternative strategies to reduce antipsychotic load. A prominent drawback of antipsychotics is their negative impact on subjective well-being, initiative, and drive related to dopamine D2 blockade. Read More

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http://dx.doi.org/10.1177/2045125319836566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457023PMC

[Depression and it's treatment in patients with schizoaffective disorder].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1. Vyp. 2):50-54

Sechenov First State Medical University, Moscow, Russia.

Aim: To study the influence of depression on the quality of remission in patients with schizoaffective disorder (SAD) and develop recommendations for anti-relapse therapy.

Material And Methods: Eighty-nine outpatients with the diagnosis of SAD were examined, in whom 348 remission cases were studied. In accordance with the characteristics of the episodes, the patients were divided into 2 main groups: patients with only depressive manifestations (group 1) and patients with affective disorders of both poles (group 2). Read More

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http://dx.doi.org/10.17116/jnevro20191191250DOI Listing
January 2019

[Depression in women - the victims of domestic violence (forensic psychiatry aspects)].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1. Vyp. 2):34-38

Serbsky National Medical Research Centre for Psychiatry and Narcology Ministry of Health of RF, Moscow, Russia.

Aim: To study the development of depressive disorders in women, the victims of domestic violence, who committed aggressive acts.

Material And Methods: Patients (n=12) were divided into two groups depending on acute depressive reaction in response to violence from husbands, which resulted in criminal acts. The first group included 4 women who killed their children and the second group included 8 women who killed their husbands. Read More

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http://dx.doi.org/10.17116/jnevro20191191234DOI Listing
January 2019
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[Regional differences in the incidence of affective disorders].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1. Vyp. 2):10-16

Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.

Aim: To analyze the dynamics of the primary indicator of morbidity of affective psychotic and non-psychotic disorders.

Material And Methods: The article uses the data of State statistical observations for the period from 2005 to 2015 years. Regional (eight federal districts) primary indicators of diagnosis of mental disorders were subjected to epidemiological analysis in general, schizophrenia and mood disorders were analyzed in more detail. Read More

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http://dx.doi.org/10.17116/jnevro20191191210DOI Listing
January 2019
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Antipsychotic treatment and basal ganglia volumes: Exploring the role of receptor occupancy, dosage and remission status.

Schizophr Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; Norwegian Centre for Research on Mental Disorders, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Norway; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.

Antipsychotic treatment may affect brain morphology, and enlargement of the basal ganglia (BG) is a replicated finding. Here we investigated associations between antipsychotic treatment and BG volumes in patients with psychotic and bipolar disorders. We hypothesized that current treatment and, among those medicated, higher dosage, estimated D2R occupancy and being in remission would predict larger BG volumes. Read More

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http://dx.doi.org/10.1016/j.schres.2019.04.002DOI Listing

Measuring empathy in schizophrenia: The Empathic Accuracy Task and its correlation with other empathy measures.

Schizophr Res 2019 Apr 18. Epub 2019 Apr 18.

University of Groningen, Department of Clinical Psychology and Experimental Psychopathology, Grote Kruisstraat 1/2, 9712 TS Groningen, the Netherlands; GGZ Noord-Drenthe, Department of Psychotic Disorders, Dennenweg 9, 9404 LA Assen, the Netherlands.

Introduction: Empathy is an interpersonal process impaired in schizophrenia. Past studies have mainly used questionnaires or performance-based tasks with static cues to measure cognitive and affective empathy. We used the Empathic Accuracy Task (EAT) designed to capture dynamic aspects of empathy by using videoclips in which perceivers continuously judge emotionally charged stories. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.024DOI Listing

Validation of the social functioning scale: Comparison and evaluation in early psychosis, autism spectrum disorder and social anxiety disorder.

Psychiatry Res 2019 Mar 26;276:45-55. Epub 2019 Mar 26.

Autism Clinic for Translational Research, Brain and Mind Centre, Central Clinical School, Faculty of Medicine, University of Sydney, Camperdown, Sydney, NSW 2050 Australia. Electronic address:

Social functioning is an important component of mental disorders for assessment and treatment. There is no recognised self-report instrument to measure social functioning across disorders where social impairment is significant. The Social Functioning Scale (SFS) has, however, been used to assess social functioning in psychotic disorders, including Schizophrenia and Early Psychosis. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.03.037DOI Listing

Psychiatric Disorders and Alcohol Consumption Among Low-Income African Americans:Gender Differences.

Brain Sci 2019 Apr 18;9(4). Epub 2019 Apr 18.

Department of Family Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.

Background: Although cooccurrence of nonsubstance use disorders (non-SUDs) and substance use is well-established in the literature, most of what we know in this regard is derived from studies that have recruited predominantly White sample populations. As a result, there is a gap in knowledge on this link among low-income African Americans (AAs). There is also a need to understand how low-income AA men and women differ in these associations. Read More

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http://dx.doi.org/10.3390/brainsci9040086DOI Listing

Clinical Characteristics of Obstructive Sleep Apnea in Psychiatric Disease.

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, 11528 Athens, Greece.

Patients with serious psychiatric diseases (major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia and psychotic disorder) often complain about sleepiness during the day, fatigue, low energy, concentration problems, and insomnia; unfortunately, many of these symptoms are also frequent in patients with Obstructive Sleep Apnea (OSA). However, existing data about the clinical appearance of OSA in Psychiatric Disease are generally missing. The aim of our study was a detailed and focused evaluation of OSA in Psychiatric Disease, in terms of symptoms, comorbidities, clinical characteristics, daytime respiratory function, and overnight polysomnography data. Read More

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https://www.mdpi.com/2077-0383/8/4/534
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http://dx.doi.org/10.3390/jcm8040534DOI Listing
April 2019
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Role of Aqueous Extract of the Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), in Avoidance of Haloperidol-lnduced Catalepsy via Oxidative Stress in Rats.

Int J Med Mushrooms 2019 ;21(4):323-330

School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017, Jaipur, India.

Haloperidol-induced catalepsy is an animal model of a psychotic disorder that may be associated with neurodegeneration and free radical damage. Auricularia polytricha is effective in both prevention and treatment of numerous types of neurological disorders. In the present study, anticataleptic activity of aqueous extract of A polytricha (AEAP) at different doses (400 and 600 mg/kg, respectively, p. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030351DOI Listing
January 2019
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Mutations From Whole Exome Sequencing in Neurodevelopmental and Psychiatric Disorders: From Discovery to Application.

Front Genet 2019 3;10:258. Epub 2019 Apr 3.

Shanghai Mental Health Center, School of Biomedical Engineering, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Neurodevelopmental and psychiatric disorders are a highly disabling and heterogeneous group of developmental and mental disorders, resulting from complex interactions of genetic and environmental risk factors. The nature of multifactorial traits and the presence of comorbidity and polygenicity in these disorders present challenges in both disease risk identification and clinical diagnoses. The genetic component has been firmly established, but the identification of all the causative variants remains elusive. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2019.00258
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http://dx.doi.org/10.3389/fgene.2019.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456656PMC
April 2019
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The Possible Role of the Angiotensin System in the Pathophysiology of Schizophrenia: Implications for Pharmacotherapy.

CNS Drugs 2019 Apr 16. Epub 2019 Apr 16.

Psychotic Disorders Program, UMASS Memorial Medical Center, Biotech One, Suite 100, 365 Plantation Street, Worcester, MA, 01605, USA.

A growing body of literature has elucidated the involvement of the central renin-angiotensin system (RAS) in various neuropsychiatric diseases. While consensus on the exact mechanism of the central RAS in schizophrenia pathophysiology does not currently exist, increasing evidence reveals promise in harnessing the therapeutic potential of RAS modulation in the treatment of schizophrenia. In this review, we examine how the central RAS affects inflammation, glutamate, dopamine, gamma-aminobutyric acid (GABA), and peroxisome proliferator-activated receptor (PPAR)-γ, all of which are associated with schizophrenia etiology. Read More

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http://dx.doi.org/10.1007/s40263-019-00632-4DOI Listing
April 2019
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Do Immune Dysregulations and Oxidative Damage Drive Mood and Psychotic Disorders?

Neuropsychobiology 2019 Apr 16:1-4. Epub 2019 Apr 16.

Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.

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https://www.karger.com/Article/FullText/496622
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http://dx.doi.org/10.1159/000496622DOI Listing
April 2019
2 Reads

Functional connectomics of affective and psychotic pathology.

Proc Natl Acad Sci U S A 2019 Apr 15. Epub 2019 Apr 15.

Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478;

Converging evidence indicates that groups of patients with nominally distinct psychiatric diagnoses are not separated by sharp or discontinuous neurobiological boundaries. In healthy populations, individual differences in behavior are reflected in variability across the collective set of functional brain connections (functional connectome). These data suggest that the spectra of transdiagnostic symptom profiles observed in psychiatric patients may map onto detectable patterns of network function. Read More

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http://dx.doi.org/10.1073/pnas.1820780116DOI Listing
April 2019
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The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders.

Nutrients 2019 Apr 2;11(4). Epub 2019 Apr 2.

Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, Italy.

Cognitive impairment is strongly associated with functional outcomes in psychiatric patients. Involvement of -3 long chain polyunsaturated fatty acid (-3 LC-PUFA), in particular docosahexaenoic acid (DHA), in brain functions is largely documented. DHA is incorporated into membrane phospholipids as structural component, especially in the central nervous system where it also has important functional effects. Read More

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https://www.mdpi.com/2072-6643/11/4/769
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http://dx.doi.org/10.3390/nu11040769DOI Listing
April 2019
2 Reads

Sociodemographic, Legal, and Clinical Profiles of Female Forensic Inpatients in Karnataka: A Retrospective Study.

Indian J Psychol Med 2019 Mar-Apr;41(2):138-143

Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.

Background: Forensic patients are often admitted to psychiatric hospitals without any details of illness or treatment. They pose a unique challenge for clinical services in the context of diagnosis, management, and particularly legal issues.

Materials And Methods: We conducted a retrospective chart review using a structured data-extraction tool. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_152_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436409PMC
April 2019
1 Read

Retinal single-layer analysis with optical coherence tomography (OCT) in schizophrenia spectrum disorder.

Schizophr Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurology, University Clinic Ulm, Germany.

Background: Volume reductions in brain structures of patients with schizophrenia spectrum disorder (SSD) have repeatedly been found in voxel-based morphometry MRI studies. Hence, an underlying neurodegenerative etiological component of SSD is currently being discussed. In recent years, the imaging method of optical coherence tomography (OCT) has shown its potential in evaluating structural changes in the retina in patients with confirmed neurodegenerative disorders, providing a window into the brain. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.022DOI Listing
April 2019
2 Reads

Red flags for suspecting anti-NMDAr encephalitis in a first psychotic episode: report of two cases.

Rev Colomb Psiquiatr 2019 Apr - Jun;48(2):127-130. Epub 2017 Dec 11.

Unidad de Neurología, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.

Anti-N-methyl-D-Aspartate receptor (NMDAr) encephalitis is a recently described clinical entity with an increasing number of reported cases. Psychiatric symptoms in the early stages of the disease constitute a diagnostic challenge for the treating physician. We present two clinical cases: clinical case 1, a 26-year-old man, and clinical case 2, an 18-year-old man; both presented with a first episode of psychosis and were hospitalized as psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.rcp.2017.10.002DOI Listing
December 2017
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Identity, Subjectivity, and Disorders of Self in Psychosis.

Cult Med Psychiatry 2019 Apr 12. Epub 2019 Apr 12.

Department of Psychiatry, The University of Toronto, Toronto, Canada.

Alterations in self-experience are increasingly attended to as relevant and important aspects of schizophrenia, and psychosis more broadly, through a burgeoning self-disorders (SD) literature. At the same time, issues of self, subject, and subjectivity within schizophrenia-spectrum illnesses have also gained attention from researchers across the social sciences and humanities, and from ethnographic research especially. This paper examines the subjective experience of disruptions in self-identity within a cohort of first episode psychosis (FEP) service users, critically engaging with the SD literature and bringing it into conversation with social sciences and humanities scholarship on self and schizophrenia. Read More

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http://link.springer.com/10.1007/s11013-019-09631-y
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http://dx.doi.org/10.1007/s11013-019-09631-yDOI Listing
April 2019
8 Reads

Using Mendelian randomisation to assess causality in observational studies.

Evid Based Ment Health 2019 Apr 12. Epub 2019 Apr 12.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

Objective: Mendelian randomisation (MR) is a technique that aims to assess causal effects of exposures on disease outcomes. The paper aims to present the main assumptions that underlie MR, the statistical methods used to estimate causal effects and how to account for potential violations of the key assumptions.

Methods: We discuss the key assumptions that should be satisfied in an MR setting. Read More

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http://dx.doi.org/10.1136/ebmental-2019-300085DOI Listing
April 2019
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Outcome of a psychosocial health promotion intervention aimed at improving physical health and reducing alcohol use in patients with schizophrenia and psychotic disorders (MINT).

Schizophr Res 2019 Apr 9. Epub 2019 Apr 9.

Dept of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

Background: Life expectancy is reduced by 19 years in men and 17 in women with psychosis in Sweden, largely due to cardiovascular disease.

Aim: Assess whether a psychosocial health promotion intervention improves cardiometabolic risk factors, quality of life, and severity of illness in patients with psychotic disorders more than treatment as usual.

Methods: A pragmatic intervention trial testing a manual-based multi-component health promotion intervention targeting patients with psychosis. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.026DOI Listing
April 2019
1 Read

Transdiagnostic Mobile Health: Smartphone Intervention Reduces Depressive Symptoms in People With Mood and Psychotic Disorders.

JMIR Ment Health 2019 Apr 12;6(4):e13202. Epub 2019 Apr 12.

Behavioral Research In Technology and Engineering Center, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States.

Background: Depression is the most prevalent mental health problem. The need for effective treatments for depression far outstrips the availability of trained mental health professionals. Smartphones and other widely available technologies are increasingly being leveraged to deliver treatments for depression. Read More

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http://dx.doi.org/10.2196/13202DOI Listing
April 2019
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[The CIMH track concept in the treatment of psychotic disorders].

Nervenarzt 2019 Apr 11. Epub 2019 Apr 11.

Klinik für Psychiatrie und Psychotherapie, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim, Universität Heidelberg, J5, 68159, Mannheim, Deutschland.

The treatment of psychotic disorders and illnesses is a challenge for therapists and institutions due to the heterogeneity of the cause and course, refractory symptoms, lack of therapy adherence and high rates of relapse. These circumstances can be effectively counteracted by the flexibility of therapeutic approaches and settings. A useful but rarely used concept is the treatment of psychoses within the so-called track unit. Read More

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http://dx.doi.org/10.1007/s00115-019-0711-9DOI Listing
April 2019
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Cognitive impairment and its improvement after six months in adolescents with schizophrenia.

Schizophr Res Cogn 2019 Sep 26;17:100135. Epub 2019 Mar 26.

Child Psychiatric Hospital, Mexico City, Mexico.

Studies evaluating the cognitive impairment in schizophrenic adolescents reported a variable course following antipsychotic treatment, with improvement being associated to patients' demographic or clinical characteristics.

Objectives: To examine the cognitive impairments of a Mexican sample of adolescents with schizophrenia using the MATRICS Consensus Cognitive Battery (MCCB) before and after six months of antipsychotic treatment and to determine which demographic or clinical characteristics could be associated to cognitive improvement.

Methods: A sample of 87 Mexican patients was evaluated with the MCCB. Read More

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http://dx.doi.org/10.1016/j.scog.2019.100135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439271PMC
September 2019
1 Read

Smoking cessation for people with severe mental illness (SCIMITAR+): a pragmatic randomised controlled trial.

Lancet Psychiatry 2019 May 8;6(5):379-390. Epub 2019 Apr 8.

Somerset Partnership NHS Foundation Trust, South Petherton, UK.

Background: People with severe mental illnesses such as schizophrenia are three times more likely to smoke than the wider population, contributing to widening health inequalities. Smoking remains the largest modifiable risk factor for this health inequality, but people with severe mental illness have not historically engaged with smoking cessation services. We aimed to test the effectiveness of a combined behavioural and pharmacological smoking cessation intervention targeted specifically at people with severe mental illness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22150366193004
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http://dx.doi.org/10.1016/S2215-0366(19)30047-1DOI Listing
May 2019
8 Reads

The prevalence and clinical correlates of cannabis use and cannabis use disorder among patients with bipolar disorder: A systematic review with meta-analysis and meta-regression.

Neurosci Biobehav Rev 2019 Apr 8;101:78-84. Epub 2019 Apr 8.

Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, Brazil; Department of Psychiatry, Federal University of Rio Grande do Sul, Brazil. Electronic address:

Bipolar disorder (BD) is commonly associated with comorbidities, especially substance use disorders. In light of this, the present review aimed to investigate the prevalence and clinical correlates of cannabis use in BD. Studies evaluating the prevalence of cannabis use among patients with BD and studies reporting a dichotomous sample of patients with cannabis use compared to those without the use were included. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.04.004DOI Listing
April 2019
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Antipsychotic medication use among working-age first-generation migrants resident in Finland: An administrative data linkage study.

Scand J Public Health 2019 Apr 11:1403494819841960. Epub 2019 Apr 11.

2 Administrative Data Research Centre - Northern Ireland, Centre for Public Health, Queen's University Belfast, UK.

Aims: Higher incidence of psychotic disorders in high-income countries for migrants compared with the settled majority has been well established. However, it is less clear to what extent different migrants groups have accessed and utilised mental health care. This study aimed to identify the hazard of antipsychotic medication use in the largest migrant groups in Finland, compared with a Finnish-born comparison group, using high quality datasets maintained by Statistics Finland and Social Insurance Institution Finland, and linking socio-demographic and -economic characteristics to antipsychotic prescription purchases. Read More

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http://dx.doi.org/10.1177/1403494819841960DOI Listing
April 2019
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Psychotic experiences and trauma predict persistence of psychosocial problems in adolescence.

Eur Child Adolesc Psychiatry 2019 Apr 9. Epub 2019 Apr 9.

Department of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Psychosocial problems during adolescence are heterogenic, rather common, and unstable. At the same time, they are associated with an elevated risk of developing psychiatric disorders later in life. We aimed to describe the trajectories of psychosocial problems during adolescence and examine potential markers of persistence as compared to remission of these problems. Read More

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http://dx.doi.org/10.1007/s00787-019-01321-9DOI Listing
April 2019
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Loss of Parietal Memory Network Integrity in Alzheimer's Disease.

Front Aging Neurosci 2019 27;11:67. Epub 2019 Mar 27.

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

A functional brain network, termed the parietal memory network (PMN), has been shown to reflect the familiarity of stimuli in both memory encoding and retrieval. The function of this network has been separated from the commonly investigated default mode network (DMN) in both resting-state fMRI and task-activations. This study examined the deficit of the PMN in Alzheimer's disease (AD) patients using resting-state fMRI and independent component analysis (ICA) and investigated its diagnostic value in identifying AD patients. Read More

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http://dx.doi.org/10.3389/fnagi.2019.00067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446948PMC
March 2019
1 Read

Risk of Psychiatric Morbidity in Psychosexual Disorders in Male Patients: A Nationwide, Cohort Study in Taiwan.

Am J Mens Health 2019 Mar-Apr;13(2):1557988319842985

6 Department of Medical Research, Tri-Service General hospital, National Defense Medical Center, Taipei, Republic of China.

This study aimed to investigate the association between males with psychosexual disorders (PSDs) and the risk of developing psychiatric disorders. A total of 34,972 enrolled patients, with 8,743 subjects who had suffered from PSD and 26,229 controls (1:3) matched for age and index year, from Taiwan's Longitudinal Health Insurance Database (LHID) from 2000 to 2015, selected from the National Health Insurance Research Database (NHIRD). After adjusting all the confounding factors, the multivariate Cox regression model was used to compare the risk of developing psychiatric disorders, between the PSD and non-PSD groups, during the 15 years of follow-up. Read More

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http://dx.doi.org/10.1177/1557988319842985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460890PMC
April 2019
2 Reads

The rs1986112 Variant is Associated with Increased RAB8B Gene Expression in Schizophrenic Patients.

Clin Lab 2019 Apr;65(4)

Background: Schizophrenia (SCZ) is a serious mental disorder that interferes with a person's cognitive processes and leads to social disability. A wide range of factors may play important roles in increased risk of SCZ development. Genetic contributors are among the most influential actors involved in different molecular mechanisms leading to the development of the nervous system, thus they play pivotal roles in psychotic disorders and SCZ de-velopment. Read More

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http://www.clin-lab-publications.com/article/2964
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http://dx.doi.org/10.7754/Clin.Lab.2018.180832DOI Listing
April 2019
2 Reads

[Autoantibody-associated schizophreniform psychoses: clinical symptomatology].

Nervenarzt 2019 Apr 9. Epub 2019 Apr 9.

Sektion für experimentelle Neuropsychiatrie, Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstr. 5, 79104, Freiburg, Deutschland.

According to present concepts, primary psychotic disorders in the schizophrenia spectrum are probably caused by a complex interaction between multigenetic vulnerability and causally relevant environmental factors. In contrast, secondary psychotic disorders are the result of likely identifiable organic factors either in terms of a first causation (etiology) or a secondary cause (pathogenesis). In this context, autoantibody(ab)-associated autoimmune encephalitis (AE) plays an increasingly important role. Read More

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http://dx.doi.org/10.1007/s00115-019-0700-zDOI Listing
April 2019
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Short duration of untreated psychosis enhances negative symptom remission in extended early intervention service for psychosis.

Acta Psychiatr Scand 2019 Apr 9. Epub 2019 Apr 9.

Department of Psychiatry, McGill University, Montreal, QC, Canada.

Objective: To test whether duration of untreated psychosis (DUP) < 3 months, recommended by the World Health Organization/International Early Psychosis Association, enhances the effects of an extended early intervention service (EEIS) on symptom remission.

Method: We examined data from a randomized controlled trial in which patients who received 2 years of treatment in EIS for psychosis were subsequently randomized to either 3 years of EEIS or 3 years of regular care (RC). Using a DUP cut-off ≤ 12 weeks (approximately < 3 months), patients were split into two groups. Read More

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http://dx.doi.org/10.1111/acps.13033DOI Listing
April 2019
1 Read

[Dimensions of mentalization in psychotic disorders].

Neuropsychopharmacol Hung 2019 Mar;21(1):5-11

Nyírő Gyula Országos Pszichiátriai és Addiktológiai Intézet, Budapest, Hungary.

The clinical assessment of mentalization became one of the most important issues in clinical psychology and psychiatry. Despite extensive research efforts, the exact definition, classification, and evaluation of mentalization is unresolved, especially in psychotic disorders. The primary purpose of the present study was to investigate the factor structure of the Mentalization Questionnaire. Read More

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March 2019
3 Reads

Lower cortisol levels and attenuated cortisol reactivity to daily-life stressors in adults with 22q11.2 deletion syndrome.

Psychoneuroendocrinology 2019 Mar 22;106:85-94. Epub 2019 Mar 22.

Center for Contextual Psychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium.

Background: 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with neurodevelopmental, anxiety and mood disorders, as well as an increased risk for developing psychosis. Cortisol levels and stress reactivity reflect hypothalamic-pituitary-adrenal (HPA)-axis activity, and are believed to be altered in individuals that often experience daily-life stress, depression, and psychotic symptoms. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.03.023DOI Listing
March 2019
3 Reads
4.944 Impact Factor

Distinguishing prodromal stage of bipolar disorder and early onset schizophrenia spectrum disorders during adolescence.

Psychiatry Res 2019 Apr 1;275:315-325. Epub 2019 Apr 1.

Ege University School of Medicine, Department of Child and Adolescent Psychiatry, Izmir, Turkey.

Prodromal symptoms of bipolar disorder (BD) and early onset schizophrenia spectrum disorder (EOSSD) overlap. To date, there has been no study directly comparing the prodromal stage of both disorders. Thus, the current study is aimed at determining which prodromal symptom clusters differentiate BD and EOSSD. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.03.051DOI Listing
April 2019
4 Reads

Anxiety symptoms across twenty-years in schizoaffective disorder, bipolar disorder, and major depressive disorder.

Psychiatry Res 2019 Mar 30;275:310-314. Epub 2019 Mar 30.

Department of Psychiatry, University of Illinois-Chicago, Chicago, IL, USA.

Anxiety symptoms and anxiety disorders are common in both mood and psychotic disorders. However, limited comparative information exists regarding the long-term course of anxiety in schizoaffective disorder, bipolar disorder, and major depressive disorder. Prospective evaluation of the 20-year trajectory of self-reported anxiety and somatic-related anxiety in three major diagnostic groups, 43 schizoaffective patients, 47 bipolar patients, and 109 major depression patients was conducted. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.03.050DOI Listing
March 2019
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Latent Profiles of Cognitive Control, Episodic Memory, and Visual Perception Across Psychiatric Disorders Reveal a Dimensional Structure.

Schizophr Bull 2019 Apr 7. Epub 2019 Apr 7.

Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, CA.

Although meta-analyses suggest that schizophrenia (SZ) is associated with a more severe neurocognitive phenotype than mood disorders such as bipolar disorder, considerable between-subject heterogeneity exists in the phenotypic presentation of these deficits across mental illnesses. Indeed, it is unclear whether the processes that underlie cognitive dysfunction in these disorders are unique to each disease or represent a common neurobiological process that varies in severity. Here we used latent profile analysis (LPA) across 3 distinct cognitive domains (cognitive control, episodic memory, and visual integration; using data from the CNTRACS consortium) to identify distinct profiles of patients across psychotic illnesses. Read More

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http://dx.doi.org/10.1093/schbul/sbz025DOI Listing
April 2019
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Cortico-thalamic dysconnection in early-stage schizophrenia: a functional connectivity magnetic resonance imaging study.

Eur Arch Psychiatry Clin Neurosci 2019 Apr 5. Epub 2019 Apr 5.

Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan.

Studies have indicated thalamus-related network dysfunction in schizophrenia and psychotic disorders. However, whether thalamus-related functional connectivity (FC) contributes to the psychopathology and cognitive deficits of early-stage schizophrenia requires further investigation. A total of 34 patients with early-stage schizophrenia (illness duration = 1. Read More

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http://dx.doi.org/10.1007/s00406-019-01003-2DOI Listing
April 2019
2 Reads
3.525 Impact Factor

Effectiveness and side effects of psychopharmacotherapy in individuals with 22q11.2 deletion syndrome with comorbid psychiatric disorders: a systematic review.

Eur Child Adolesc Psychiatry 2019 Apr 4. Epub 2019 Apr 4.

The Child Psychiatry Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, 5262000, Tel Hashomer, Israel.

22q11.2 deletion syndrome (22q11.2DS) is the most common microdeletion in humans and is associated with high rates of attention deficit/hyperactivity disorder (ADHD), psychotic spectrum disorders and mood and anxiety disorders. Read More

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http://dx.doi.org/10.1007/s00787-019-01326-4DOI Listing
April 2019
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Effectiveness of Direct-Acting Antiviral Therapy in Patients With Human Immunodeficiency Virus-Hepatitis C Virus Coinfection in Routine Clinical Care: A Multicenter Study.

Open Forum Infect Dis 2019 Apr 23;6(4):ofz100. Epub 2019 Mar 23.

Department of Medicine, University of Washington, Seattle.

Background: Direct-acting antiviral (DAA) therapy have been shown to be highly successful in clinical trials and observational studies, but less is known about treatment success in patients with a high burden of comorbid conditions, including mental health and substance use disorders. We evaluated DAA effectiveness across a broad spectrum of patients with human immunodeficiency virus (HIV)-hepatitis C virus (HCV) coinfection in routine clinical care, including those with psychosocial comorbid conditions.

Methods: The primary end point was sustained virologic response (SVR), defined as HCV RNA not detected or <25 IU/mL ≥10 weeks after treatment. Read More

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http://dx.doi.org/10.1093/ofid/ofz100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441587PMC
April 2019
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Autoimmune Diseases and Psychotic Disorders.

Front Psychiatry 2019 20;10:131. Epub 2019 Mar 20.

Mental Health Centre Copenhagen, Gentofte Hospital, Copenhagen University Hospital, Hellerup, Denmark.

The notion of immunological pathways playing a role in the etiology of a subset of psychotic disorders has received increased interest in the last decades. One of the findings that has spiked interest herein, is an apparent link between autoimmune diseases and psychotic disorders. This is supported by genetic findings associating immune-related genetic markers with schizophrenia and clinical studies finding increased levels of inflammatory markers in patients with psychosis. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435494PMC
March 2019
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Predictors of Compulsory Re-admission to Psychiatric Inpatient Care.

Front Psychiatry 2019 21;10:120. Epub 2019 Mar 21.

Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, Zurich, Switzerland.

This prospective study addresses risk factors of compulsory re-admission focusing on the role of the patient's subjective symptom distress and perceived social support, based on comprehensive patient and external (clinicians, study staff) assessments. Of the baseline sample, 168 (71%) patients with serious mental disorders, who had been compulsorily admitted to psychiatric inpatient care, were followed over 24 months after discharge within the framework of a RCT. During this time 36% had compulsory re-admissions; risk was highest immediately after discharge. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437043PMC
March 2019
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Massive pulmonary embolism presenting initially as acute psychosis.

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.

This is a case of a 68-year-old man with Parkinson's disease who was admitted in the psychiatry floor for new-onset aggressive behaviour and hallucinations. On the third day of hospitalisation, he suddenly developed dyspnoea followed by an ECG showing atrial fibrillation with rapid ventricular response. A few seconds later, he went into cardiac arrest; he was resuscitated after multiple rounds of Advanced Cardiovascular Life Support. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2017-22201
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http://dx.doi.org/10.1136/bcr-2017-222018DOI Listing
April 2019
7 Reads