351 results match your criteria Schizencephaly Imaging


A journey through formation and malformations of the neo-cortex.

Childs Nerv Syst 2020 01 27;36(1):27-38. Epub 2019 Nov 27.

Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, 110029, India.

Purpose: Malformations of cortical development (MCD) are a heterogeneous group of disorders characterized by abnormal structure of the cerebral cortex. MCDs are an important cause of development delay and intractable epilepsy in children. In this review, we explore the embryological stages of development of neo-cortex, the imageology of various malformations which may occur during the journey of this development, the recent advances in imaging techniques used for diagnosing these malformations, and finally a simplified radiological approach to malformations of cortical development. Read More

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http://dx.doi.org/10.1007/s00381-019-04429-0DOI Listing
January 2020

Persistent falcine sinus with temporo-occipital schizencephaly: case report with a review of literature in relation to the undeveloped vein of Galen and/or straight sinus.

Childs Nerv Syst 2020 02 1;36(2):417-421. Epub 2019 Jun 1.

Department of Radio-Diagnosis, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, 600506, India.

Falcine sinus is a normal midline embryonic venous sinus present in the fetal brain and usually disappears by birth. Persistent falcine sinus (PFS) has been reported as a normal variant or along with vein of Galen (VOG) malformation, encephalocele, and other abnormalities. Schizencephaly, either closed or open type, has been reported with other associated vascular anomalies. Read More

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http://dx.doi.org/10.1007/s00381-019-04234-9DOI Listing
February 2020
9 Reads

Cortical malformations and COL4A1 mutation: Three new cases.

Eur J Paediatr Neurol 2019 May 22;23(3):410-417. Epub 2019 Feb 22.

Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; Child and Adolescence Neurology Unit, IRCCS Mondino Foundation, Pavia, Italy.

Aim: The COL4A1 gene (13q34) encodes the α1 chain of type IV collagen, a crucial component of the basal membrane. COL4A1 mutations have been identified as a cause of a multisystem disease. Brain MRI in COL4A1-mutated patients typically shows vascular abnormalities and white matter lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183043
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http://dx.doi.org/10.1016/j.ejpn.2019.02.006DOI Listing
May 2019
22 Reads

Septo-optic Dysplasia Plus Syndrome.

Cureus 2018 Dec 13;10(12):e3727. Epub 2018 Dec 13.

Neurology, Hospital Civil De Guadalajara "Fray Antonio Alcalde", Guadalajara, MEX.

Septo-optic dysplasia plus is a rare congenital syndrome characterized by the classic triad of optic nerve hypoplasia, hypothalamic-hypophyseal dysfunction, and midline abnormalities, with associated malformations of cortical development. Clinical manifestations include optic nerve disease, epilepsy, intellectual delay, and endocrine dysfunction. We present the case of an 18-year-old man with a history of seizures, growth hormone deficiency, and optic nerve disease that was diagnosed with septo-optic dysplasia plus syndrome with characteristic imaging findings. Read More

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http://dx.doi.org/10.7759/cureus.3727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384050PMC
December 2018
8 Reads

Frontoethmoidal encephalocele presenting in concert with schizencephaly.

Surg Neurol Int 2018 4;9:246. Epub 2018 Dec 4.

Department of Neurosurgery, Aga Khan University Hospital, Karachi, Pakistan.

Background: Schizencephaly is a rare defect which is identified as clefts that are lined with grey matter extending from the ependyma of the cerebral ventricles to the pia mater. An encephalocele occurs due to failure of neural tube closure resulting in a gap through which cerebrospinal fluid and meninges can bulge into a pouch. There have been rare instances when these two defects have presented simultaneously. Read More

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http://surgicalneurologyint.com/surgicalint-articles/frontoe
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http://dx.doi.org/10.4103/sni.sni_242_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293601PMC
December 2018
33 Reads

Fetal stroke and cerebrovascular disease: Advances in understanding from lenticulostriate and venous imaging, alloimmune thrombocytopaenia and monochorionic twins.

Eur J Paediatr Neurol 2018 Nov 11;22(6):989-1005. Epub 2018 Sep 11.

Departments of Child Health, Obstetrics and Gynaecology and Radiology, University Hospital Southampton, United Kingdom; Clinical and Experimental Sciences, University of Southampton, United Kingdom.

Fetal stroke is an important cause of cerebral palsy but is difficult to diagnose unless imaging is undertaken in pregnancies at risk because of known maternal or fetal disorders. Fetal ultrasound or magnetic resonance imaging may show haemorrhage or ischaemic lesions including multicystic encephalomalacia and focal porencephaly. Serial imaging has shown the development of malformations including schizencephaly and polymicrogyra after ischaemic and haemorrhagic stroke. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.08.008DOI Listing
November 2018
42 Reads

Incongruent hemiatrophy and hemiparkinsonism in a patient with schizencephaly.

Clin Neurol Neurosurg 2018 12 25;175:106-107. Epub 2018 Oct 25.

Department of Neurology, Kyung Hee University Hospital, 23, Kyungheedae-ro, Dongdaemun-gu, 02447 Seoul, Republic of Korea; Department of Neurology, College of Medicine, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, 02447 Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.clineuro.2018.10.008DOI Listing
December 2018
3 Reads

Increased Sylvian fissure angle as early sonographic sign of malformation of cortical development.

Ultrasound Obstet Gynecol 2019 Aug 8;54(2):199-206. Epub 2019 Jul 8.

Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR.

Objective: To evaluate Sylvian fissure development by assessing Sylvian fissure angles in fetuses with malformation of cortical development (MCD).

Methods: This was a retrospective study of 22 fetuses with MCD. Cases with a stored three-dimensional (3D) brain volume acquired at 18 + 0 to 30 + 6 weeks of gestation at an ultrasound-based research clinic between January 2010 and December 2017 were identified through a database. Read More

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http://doi.wiley.com/10.1002/uog.20171
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http://dx.doi.org/10.1002/uog.20171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772089PMC
August 2019
4 Reads

Further refinement of COL4A1 and COL4A2 related cortical malformations.

Eur J Med Genet 2018 Dec 11;61(12):765-772. Epub 2018 Oct 11.

Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France; Laboratory of Embryology and Genetics of Congenital Malformations, INSERM UMR 1163, Imagine Institute, Paris, France; Pediatric Neurology, APHP- Necker Enfants Malades Hospital, Paris, France; National Rare Disease Center- Centre de Référence "Déficiences Intellectuelles de Causes Rares", AP-HP, Necker Enfants Malades, 75015, Paris, France. Electronic address:

Mutations in COL4A1 have been reported in schizencephaly and porencephaly combined with microbleeds or calcifications, often associated with ocular and renal abnormalities, myopathy, elevated creatine kinase levels and haemolytic anaemia. In this study, we aimed to clarify the phenotypic spectrum of COL4A1/A2 mutations in the context of cortical malformations that include schizencephaly, polymicrogyria and/or heterotopia.

Methods: We screened for COL4A1/A2 mutations in 9 patients with schizencephaly and/or polymicrogyria suspected to be caused by vascular disruption and leading to a cerebral haemorrhagic ischaemic event. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697212173084
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http://dx.doi.org/10.1016/j.ejmg.2018.10.004DOI Listing
December 2018
52 Reads

A Patient with Schizencephaly and Agenesis of Corpus Callosum with No Neurological Deficits.

J Neurosci Rural Pract 2018 Jul-Sep;9(3):404-405

Department of Medicine - Division of Neurology, St. George Hospital University Medical Center, University of Balamand, Lebanon.

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http://dx.doi.org/10.4103/jnrp.jnrp_564_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050766PMC
August 2018
42 Reads

Schizencephaly revisited.

Authors:
Paul D Griffiths

Neuroradiology 2018 Sep 19;60(9):945-960. Epub 2018 Jul 19.

Academic Unit of Radiology, University of Sheffield, Floor C, Glossop Road, Sheffield, England, S10 2JF, UK.

Purpose: In this paper, I will report the range of appearances of schizencephaly in children and fetuses by reviewing a 10-year experience from a single centre and detail classification systems for the different forms of schizencephaly. This will lead to re-assessment of possible aetiological and mechanistic causes of schizencephaly.

Methods: All cases of pediatric and fetal schizencephaly were located on the local database between 2007 and 2016 inclusive. Read More

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http://dx.doi.org/10.1007/s00234-018-2056-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096842PMC
September 2018
33 Reads

A rare case of super-refractory epileptic status in pregnant woman: Schizencephaly.

Anaesth Crit Care Pain Med 2019 04 31;38(2):195-198. Epub 2018 Jul 31.

Pole of anesthesia resuscitation and emergencies, Military Hospital Moulay Ismail, Meknès, Morocco.

Schizencephaly is an anomaly of the subtotal brain development, which occurs as the presence of a cleft lined with grey matter extending from subarachnoid space to the ventricles. It may be manifested by psychomotor retardation, paresis or partial seizures and drug-resistant convulsions. The clinical expression of schizencephaly depends on the bilaterality of the slit, its size and its seat. Read More

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http://dx.doi.org/10.1016/j.accpm.2018.06.002DOI Listing
April 2019
22 Reads

Latent Schizencephaly With Psychotic Phenotype or Schizophrenia With Schizencephaly? A Case Report and Review of the Literature.

Clin EEG Neurosci 2019 Jan 18;50(1):13-19. Epub 2018 Jun 18.

1 National Institute of Mental Health, Klecany, Topolová 748, Czech Republic.

Objectives: Although schizencephaly belongs to the class of neurodevelopmental disorders, which are a well-known predisposing factor for psychosis, there is a lack of relevant studies and diagnostic guidelines on this relationship.

Method: A case report of first-episode psychosis with persistent negative symptoms associated with schizencephaly is described and compared with 7 other cases found in the literature.

Results: We found perinatal pathology, cognitive deficit, and EEG abnormality in a patient with atypical initial symptoms of psychosis such as olfactory hallucinations. Read More

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http://dx.doi.org/10.1177/1550059418781119DOI Listing
January 2019
48 Reads

[Disorders of migration and gyration].

Authors:
I Pogledic

Radiologe 2018 Jul;58(7):653-658

Universitätsklinik für Radiologie und Nuklearmedizin, Klinische Abteilung für Neuroradiologie und Muskuloskeletale Radiologie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Disorders of migration and gyration are a versatile group of pathologies that may cause epilepsy and/or neurodevelopmental delay. With the recent improvement of imaging methods, it is possible to detect these pathologies, not only on postnatal MRI but also in utero using fetal MRI. The use of MRI together with genetic tests and knowledge of the classification of these malformations makes early diagnosis possible. Read More

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http://dx.doi.org/10.1007/s00117-018-0400-xDOI Listing
July 2018
3 Reads

Novel mutation in a fetus with early prenatal onset of schizencephaly.

Hum Genome Var 2018 24;5. Epub 2018 Apr 24.

1Division of Medical Genetics, Kanagawa Children's Medical Center, Yokohama, Japan.

Porencephaly and schizencephaly are congenital brain disorders that can be caused by mutations, though the underlying mechanism and developmental processes are poorly understood. Here, we report a patient with schizencephaly, detected by fetal ultrasonography and fetal magnetic resonance imaging, with a de novo novel mutation in (c.2645_2646delinsAA, p. Read More

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http://dx.doi.org/10.1038/s41439-018-0005-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938052PMC
April 2018
6 Reads

Septo-optic Dysplasia : Assessment of Associated Findings with Special Attention to the Olfactory Sulci and Tracts.

Clin Neuroradiol 2019 Sep 16;29(3):505-513. Epub 2018 Apr 16.

Department of Radiology, University of Minnesota Medical Center, MMC 292, B‑212 Mayo, 420 DelawareStreet SE, 55455, Minneapolis, MN, USA.

Purpose: Septo-optic dysplasia is a congenital disorder consisting of optic nerve hypoplasia and absent septum pellucidum. While associated anomalies have been described, olfactory sulcus and bulb-tract hypoplasia have been scantily reported and was the focus of this study.

Methods: The picture archival and communications system and radiology information system (PACS-RIS) was searched over 15 years for patients with suspected septo-optic dysplasia (n = 41) and cerebral magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1007/s00062-018-0687-zDOI Listing
September 2019
13 Reads

Schizencephaly and Porencephaly Due to Fetal Intracranial Hemorrhage: A Report of Two Cases.

Yonago Acta Med 2017 12 5;60(4):241-245. Epub 2018 Feb 5.

Division of Reproductive-Perinatal Medicine and Gynecologic Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.

Schizencephaly and porencephaly are extremely rare types of cortical dysplasia. Case 1: Prenatal magnetic resonance imaging (MRI) showed wide clefts in the frontal and parietal lobes bilaterally. On postnatal day 3, MRI T2-weighted images showed multiple hypointensities in the clefts and ventricular walls, suggestive of hemosiderosis secondary to intracranial hemorrhage. Read More

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http://dx.doi.org/10.24563/yam.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803161PMC
December 2017
6 Reads

Schizencephaly in children: A single medical center retrospective study.

Pediatr Neonatol 2018 12 6;59(6):573-580. Epub 2018 Jan 6.

Division of Neuroradiology, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.

Background: The aim of this study was to evaluate the clinical, and neuroimaging features, outcomes, and other associated systemic disorders in children with schizencephaly at a single medical center in Taiwan.

Methods: We retrospectively reviewed the medical records and magnetic resonance images (MRI) of children with schizencephaly between January 2000 and December 2014. The MRI findings of schizencephaly were recorded along with the presence of associated cerebral disorders. Read More

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http://dx.doi.org/10.1016/j.pedneo.2018.01.009DOI Listing
December 2018
11 Reads

A rare case of schizencephaly in an adult with late presentation.

J Family Med Prim Care 2017 Apr-Jun;6(2):450-452

Department of Oral Medicine and Radiology, VSPM Dental College and Research Centre, Nagpur, Maharashtra, India.

Schizencephaly, i.e., split brain, is a rare, congenital cerebral malformation. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_43_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749106PMC
January 2018
12 Reads

Neuronal Migration Disorders.

Authors:
Benjamin Roberts

Radiol Technol 2018 Jan;89(3):279-295

Enhanced understanding of brain development has led to increased awareness of the links between disorders of neuronal migration and seizure disorders. A significant number of patients with intractable epilepsy have cortical malformations that originated during neuronal migration. Magnetic resonance imaging plays a primary role in the diagnosis and classification of neuronal migration disorders. Read More

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January 2018
8 Reads

and fetal vascular origins of schizencephaly.

Neurology 2018 01 27;90(5):232-234. Epub 2017 Dec 27.

From Children's Mercy Hospital and Clinics (R.K.), Kansas City, MO; and The Hospital for Sick Children (P.K., K.A., S.B., S.M., M.M., N.D.), Toronto, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000004890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791794PMC
January 2018
30 Reads

Prenatal and postnatal evaluation of polymicrogyria with band heterotopia.

Radiol Case Rep 2017 Sep 27;12(3):602-605. Epub 2017 May 27.

Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3026, USA.

The coexistence of band heterotopia and polymicrogyria is extremely rare though it has been reported in the presence of corpus callosum anomalies and megalencephaly. We present prenatal and postnatal MRI findings of a rare case of diffuse cortical malformation characterized by polymicrogyria and band heterotopia. Agenesis of the corpus callosum and megalencephaly were also noted. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433173001
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http://dx.doi.org/10.1016/j.radcr.2017.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551996PMC
September 2017
9 Reads

Functional brain neuroimaging-guided repetitive transcranial magnetic stimulation in neurodevelopmental disorders: The case of a schizencephaly-related spastic dystonia.

J Neurol Sci 2017 07 10;378:167-169. Epub 2017 May 10.

C2S Laboratory (EA 6291), University of Reims Champagne-Ardenne, Reims, France; Department of Adult Psychiatry, Robert Debré Hospital, Reims University Hospital, Reims, France.

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http://dx.doi.org/10.1016/j.jns.2017.05.012DOI Listing
July 2017
23 Reads

Clinical and Radiologic Spectrum of Septo-optic Dysplasia: Review of 17 Cases.

J Child Neurol 2017 08 8;32(9):797-803. Epub 2017 May 8.

2 Departments of Pediatrics, Neurology, and Neurosurgery, McGill University, Montreal, Quebec, Canada.

We retrospectively reviewed the clinical and radiologic characteristics of 17 individuals with septo-optic dysplasia (SOD) and attempted to identify correlations between imaging findings, clinical features, and neurodevelopmental outcome. Surprisingly, only 1 (6%) individual was classified as classic SOD (with septum pellucidum/corpus callosum dysgenesis), 3 (18%) as SOD-like (with normal septum pellucidum/corpus callosum) and the majority, 13 (76%), as SOD-plus (with cortical brain malformation). Cortical abnormalities included schizencephaly, polymicrogyria, and gray matter heterotopias. Read More

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http://dx.doi.org/10.1177/0883073817707300DOI Listing
August 2017
44 Reads

Imaging of Laser Therapy in Epilepsy.

J Neuroimaging 2017 05 29;27(3):292-299. Epub 2017 Mar 29.

Department of Neurology, Epilepsy Section, University of Colorado Denver School of Medicine, Aurora, CO.

Background And Purpose: MR-guided laser interstitial thermal therapy (MRgLITT) is an increasingly popular neuroablative method for the surgical treatment of epilepsy patients. This article intends to demonstrate the utility and pitfalls of imaging in the context of patient care with MRgLITT.

Material And Methods: A retrospective review of the medical records and imaging database with six illustrative cases selected to demonstrate the use of imaging throughout patient management with MRgLITT in diverse clinical situations and pathologies. Read More

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http://dx.doi.org/10.1111/jon.12438DOI Listing
May 2017
10 Reads

Recurrence of Epileptic Spasms as Reflex Seizures Induced by Eating: A Case Report and Literature Review.

Neuropediatrics 2017 Apr 23;48(2):119-122. Epub 2017 Jan 23.

Department of Pediatrics, Hiroshima University Hospital, Hiroshima, Japan.

 Eating epilepsy (EE) is a rare form of reflex epilepsy in which seizures are induced by eating. It is known that most patients with eating seizures, in fact, suffer from symptomatic temporal lobe epilepsy (TLE), whereas only a few patients with epileptic spasms induced by eating (E-ES) have been reported.  The patient was an 8-year-old girl whose magnetic resonance imaging (MRI) of the head detected dysgenesis of the corpus callosum, cerebellar hypogenesis, marked cerebral asymmetry, broad polymicrogyria, periventricular heterotopia, and closed lip-type schizencephaly. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1598111
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http://dx.doi.org/10.1055/s-0037-1598111DOI Listing
April 2017
22 Reads

Teaching NeuroImages: Homotopic motor distribution on fMRI in closed-lip schizencephaly.

Neurology 2017 01;88(2):e24-e25

From the Center for Neuroscience and Behavioral Medicine (L.B., A.K., A.Z., W.D.G.) and the Division of Diagnostic Imaging and Radiology (J.G.M.), Children's National Health System, The George Washington University, Washington, DC.

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http://dx.doi.org/10.1212/WNL.0000000000003493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224712PMC
January 2017
31 Reads

Fetal Central Nervous System Anomalies Detected by Magnetic Resonance Imaging: A Two-Year Experience.

Iran J Pediatr 2016 Aug 6;26(4):e4589. Epub 2016 Jun 6.

Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, IR Iran.

Background: Magnetic resonance imaging (MRI) is gradually becoming more common for thorough visualization of the fetus than ultrasound (US), especially for neurological anomalies, which are the most common indications for fetal MRI and are a matter of concern for both families and society.

Objectives: We investigated fetal MRIs carried out in our center for frequency of central nervous system anomalies. This is the first such report in southern Iran. Read More

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http://dx.doi.org/10.5812/ijp.4589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046157PMC
August 2016
23 Reads

Tadpole-shaped lateralized parietal atretic cephalocele associated with an ipsilateral lacrimal gland fistula and schizencephalic clefts.

Childs Nerv Syst 2017 Feb 4;33(2):363-367. Epub 2016 Oct 4.

Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Parietal atretic cephalocele (AC) and its associated intracranial venous anomalies, such as vertical embryonic positioning of the straight sinus (VEP of SS), have, in previous reports, been exclusively restricted to the midline.

Clinical Presentation: We report a patient with lateralized parietal AC on the right side. The AC was in the shape of a tadpole, with a large head and a long tail, extending to the proximity of the right external canthus, where a lacrimal gland fistula was observed. Read More

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http://dx.doi.org/10.1007/s00381-016-3254-4DOI Listing
February 2017
30 Reads

Cortical Clefts and Cortical Bumps: A Continuous Spectrum.

J Clin Diagn Res 2016 Jul 1;10(7):TD01-2. Epub 2016 Jul 1.

Specialist Grade I, Indira Gandhi Government General Hospital and Post Graduate Institute , Puducherry, India .

Cortical 'clefts' (schizencephaly) and cortical 'bumps' (polymicrogyria) are malformations arising due to defects in postmigrational development of neurons. They are frequently encountered together, with schizencephalic clefts being lined by polymicrogyria. We present the case of an eight-year-old boy who presented with seizures. Read More

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http://dx.doi.org/10.7860/JCDR/2016/20343.8179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020188PMC
July 2016
6 Reads

Bilateral giant open-lip schizencephaly: A rare case report.

J Pediatr Neurosci 2016 Apr-Jun;11(2):128-30

Department of Neurosurgery, Sri Aurobindo Medical College and PG Institute, Indore, Madhya Pradesh, India.

Schizencephaly is an extremely rare developmental birth defect characterized by abnormal slits or clefts in the cerebral hemispheres extending from the lateral ventricle to the cerebral cortex. The margins of the cleft are lined with heterotropic, dysplastic gray matter. The causes of schizencephaly are heterogeneous and include teratogens, prenatal infarction/infections, maternal trauma, or EMX2 mutations. Read More

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http://dx.doi.org/10.4103/1817-1745.187638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991154PMC
September 2016
8 Reads

Telencephalic Flexure and Malformations of the Lateral Cerebral (Sylvian) Fissure.

Pediatr Neurol 2016 10 10;63:23-38. Epub 2016 May 10.

Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.

After sagittal division of the prosencephalon at 4.5 weeks of gestation, the early fetal cerebral hemisphere bends or rotates posteroventrally from seven weeks of gestation. The posterior pole of the telencephalon thus becomes not the occipital but the temporal lobe as the telencephalic flexure forms the operculum and finally the lateral cerebral or Sylvian fissure. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2016.05.005DOI Listing
October 2016
17 Reads

Successful hemispherotomy for a patient with intractable epilepsy secondary to bilateral congenital brain malformation with lateralized pyramidal tract of diffusion tensor image tractography.

Epilepsy Behav Case Rep 2016 11;6:30-2. Epub 2016 Feb 11.

Seirei Hamamatsu General Hospital, Comprehensive Epilepsy Center, Japan.

Purpose: To perform an epilepsy surgery on a patient with drug resistant epilepsy secondary to bilateral brain malformation. The patient was a 2-year 9-month-old boy who had congenital bilateral multiple abnormalities. He developed a complex partial seizure at 9 months old. Read More

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http://dx.doi.org/10.1016/j.ebcr.2016.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941043PMC
July 2016
30 Reads

The pathology of incipient polymicrogyria.

Brain Dev 2017 Jan 9;39(1):23-39. Epub 2016 Jul 9.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: To characterise the early tissue changes of post encephaloclastic polymicrogyria in the human fetus.

Methods: We identified and reviewed the clinical histories and autopsy pathology of post ischemic fetal cerebral cortical injury at less than 30weeks gestational age (GA). The histology of local cortical abnormalities was examined with neuronal, glial, microglial and vascular immunohistochemical markers. Read More

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http://dx.doi.org/10.1016/j.braindev.2016.06.005DOI Listing
January 2017
30 Reads

Contactin-associated protein-like (CNTNAP) 2 gene mutation in a patient with bilateral schizencephaly.

Authors:
Debopam Samanta

Acta Neurol Belg 2017 03 27;117(1):403-404. Epub 2016 May 27.

Department of Pediatrics, Division of Child Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

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http://dx.doi.org/10.1007/s13760-016-0653-yDOI Listing
March 2017
9 Reads

Schizencephaly: A case report and review of literature.

Niger Postgrad Med J 2016 Jan-Mar;23(1):38-40

Department of Radiology, University of Port Harcourt Teaching Hospital and University of Port Harcourt, Port Harcourt, Rivers State, Nigeria.

Schizencephaly is a congenital condition characterized by cerebrospinal fluid-filled clefts that extend from the pia surface of the cerebral hemisphere to the ependymal surface of the ventricle. Magnetic resonance imaging is the modality of choice for its diagnosis. Very few cases have been described in the literature in this environment. Read More

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http://dx.doi.org/10.4103/1117-1936.180181DOI Listing
August 2018
6 Reads

Scalp Arteriovenous Malformation with Concomitant, Flow-Dependent Malformation and Aneurysm.

World Neurosurg 2016 Jun 25;90:708.e5-708.e9. Epub 2016 Mar 25.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, USA. Electronic address:

Background: Scalp arteriovenous malformations (sAVMs) are well-described congenital abnormalities for which co-occurrence with other vascular pathologies significantly alters management strategies. The authors describe a case in which congenital sAVM was found with concomitant intracranial, flow-dependent vascular malformation and schizencephalic developmental anomaly.

Case Description: A 21-year-old man presented with a right-sided bruit and an enlarging palpable, pulsatile scalp mass. Read More

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http://dx.doi.org/10.1016/j.wneu.2016.03.047DOI Listing
June 2016
28 Reads

Successful surgery for refractory seizures associated with bilateral schizencephaly: two case reports and literature review.

Neurol Sci 2016 Jul 10;37(7):1079-88. Epub 2016 Mar 10.

Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China.

Schizencephaly is a rare malformation of cortical development resulting from cell migration defects that occur unilaterally or bilaterally. The type of the schizencephalic cleft can be open lip or closed lip. Patients suffering from refractory seizures secondary to schizencephaly should be considered for surgical treatment. Read More

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http://dx.doi.org/10.1007/s10072-016-2543-8DOI Listing
July 2016
29 Reads

Prenatal diagnosis of chromosome 8p23.1 microdeletion by array comparative genomic hybridization using uncultured amniocytes in a pregnancy associated with fetal partial corpus callosum agenesis and schizencephaly.

Taiwan J Obstet Gynecol 2015 Dec;54(6):797-8

Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan; Department of Bioengineering, Tatung University, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.tjog.2015.10.023DOI Listing
December 2015
25 Reads

Surgical management of medically refractory epilepsy in patients with polymicrogyria.

Epilepsia 2016 Jan 9;57(1):151-61. Epub 2015 Dec 9.

Department of Neurological Surgery, UCSF Comprehensive Epilepsy Center, University of California, San Francisco, California, U.S.A.

Objective: Polymicrogyria (PMG) is a malformation of cortical development characterized by formation of an excessive number of small gyri. Sixty percent to 85% of patients with PMG have epilepsy that is refractory to medication, but surgical options are usually limited. We characterize a cohort of patient with polymicrogyria who underwent epilepsy surgery and document seizure outcomes. Read More

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http://dx.doi.org/10.1111/epi.13264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237579PMC
January 2016
55 Reads
4.571 Impact Factor

Intracranial sonographic features demonstrating in utero development of hemorrhagic brain damage leading to schizencephaly-associated COL4A1 mutation.

J Med Ultrason (2001) 2015 Jul 18;42(3):445-6. Epub 2015 Jan 18.

Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1007/s10396-015-0610-zDOI Listing
July 2015
11 Reads

ERRATA: Intracranial Hemorrhage and Tortuosity of Veins Detected on Susceptibility-weighted Imaging of a Child with a Type IV Collagen α1 Mutation and Schizencephaly.

Authors:

Magn Reson Med Sci 2015 ;14(4):373

Reason for correction: There is an error of the year of publication.Details: We have to correct the issue year from 2014 to 2015. Read More

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http://dx.doi.org/10.2463/mrms.2014-0060erDOI Listing
February 2016
5 Reads

Neuroepidemiology of Porencephaly, Schizencephaly, and Hydranencephaly in Miyagi Prefecture, Japan.

Pediatr Neurol 2016 Jan 28;54:39-42.e1. Epub 2015 Aug 28.

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan; Department of Pediatric Neurology, Takuto Rehabilitation Center for Children, Sendai, Japan. Electronic address:

Background: No population-based surveys of porencephaly, schizencephaly, and hydranencephaly have been conducted in Japan or other Asian countries. We performed a neuroepidemiologic analysis to elucidate the incidence of porencephaly, schizencephaly, and hydranencephaly in Miyagi prefecture, Japan, during 2007-2011.

Methods: We sent inquiry forms in February 2012 to three neonatal intensive care units, 25 divisions of orthopedic surgery in municipal hospitals, 33 divisions of pediatrics including one university hospital, municipal hospitals, pediatric practitioners, and institutions for physically handicapped children located in Miyagi prefecture. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2015.08.016DOI Listing
January 2016
48 Reads

Malformations of cortical development: 3T magnetic resonance imaging features.

World J Radiol 2015 Oct;7(10):329-35

Bilal Battal, Selami Ince, Veysel Akgun, Murat Kocaoglu, Emrah Ozcan, Mustafa Tasar, Department of Radiology, Gulhane Military Medical School, 06018 Etlik, Ankara, Turkey.

Malformation of cortical development (MCD) is a term representing an inhomogeneous group of central nervous system abnormalities, referring particularly to embriyological aspect as a consequence of any of the three developmental stages, i.e., cell proliferation, cell migration and cortical organization. Read More

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http://www.scielo.br/pdf/anp/v69n1/24.pdf
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http://www.wjgnet.com/1949-8470/full/v7/i10/329.htm
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http://dx.doi.org/10.4329/wjr.v7.i10.329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620113PMC
October 2015
14 Reads

[Scintigraphic imaging in the diagnosis of failed intrathecal baclofen therapy: a case report of a 7-year-old boy with ventriculoperitoneal shunt].

No To Hattatsu 2015 Sep;47(5):367-71

Intrathecal baclofen (ITB) therapy is popular for the management of intractable spasticity. In 2007, the indications of ITB therapy expanded to include spasticity of children in Japan. In this report, we assessed the utility of radioisotopic scintigraphy in the diagnosis of failed ITB therapy. Read More

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September 2015
22 Reads

Central nervous system injury in utero: selected entities.

Pediatr Radiol 2015 Sep 7;45 Suppl 3:S454-62. Epub 2015 Sep 7.

Department of Radiology, Icahn School of Medicine at Mt. Sinai, Internal Mail Box 1234, One Gustave Levy Place, New York, NY, 10024, USA,

This report discusses the syndrome of amnionic bands, anencephaly, schizencephaly and hydranencephaly, four entities whose pathogenesis includes significant injury to the fetus in utero. Read More

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http://dx.doi.org/10.1007/s00247-015-3344-6DOI Listing
September 2015
12 Reads

Schizencephaly. .

J Assoc Physicians India 2014 Oct;62(10):45-6

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October 2014
23 Reads

Schizencephaly: Dramatic Images in a Normally Functioning Adult.

PM R 2015 Aug 28;7(8):901-902. Epub 2015 Mar 28.

Department of Physical Medicine and Rehabilitation, Temple University School of Medicine, Philadelphia, PA 19140.

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http://dx.doi.org/10.1016/j.pmrj.2015.03.018DOI Listing
August 2015
18 Reads

Clinical Profile of Children with Malformations of Cortical Development.

Indian J Pediatr 2015 Jul 25;82(7):591-4. Epub 2015 Feb 25.

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Objective: To elucidate the clinical-radiological profile of children with malformations of cortical development.

Methods: This observational study was conducted at a tertiary care child hospital of north India. Clinical-radiological data records were reviewed and assessment of children's functioning in five key areas of physical, adaptive behavior, social emotional, cognitive and communication was performed using Developmental Profile-3. Read More

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http://dx.doi.org/10.1007/s12098-015-1723-5DOI Listing
July 2015
10 Reads

Schizencephaly-diagnostics and clinical dilemmas.

Childs Nerv Syst 2015 Apr 18;31(4):551-6. Epub 2015 Feb 18.

Department of Radiology, Polish-American Institute of Pediatrics/Jagiellonian University, 265 Wielicka St., 30-663, Kraków, Poland,

Background: Schizencephaly is an uncommon congenital disorder of cerebral cortical development. The defect is characterized by the presence of a cleft in the brain extending from the surface of the pia mater to the cerebral ventricles. The margins of the cleft are lined with heterotropic, dysplastic gray matter. Read More

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http://dx.doi.org/10.1007/s00381-015-2638-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359713PMC
April 2015
10 Reads