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Parasite Immunol 2018 Sep 21:e12591. Epub 2018 Sep 21.

Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

While antigens from Schistosoma schistosomula have been suggested as potential vaccine candidates, the association between antibody responses to schistosomula antigens and infection intensity at reinfection is not well-known. Schistosoma mansoni infected individuals were recruited from a schistosomiasis endemic area in Uganda (n=372), treated with 40mg/kg praziquantel (PZQ) and followed up at five weeks and at one-year post-treatment. Pre-treatment and five-week post-treatment immunoglobulin (Ig) E, IgG1 and IgG4 levels against recombinant schistosomula antigens rSmKK7, rSmLy6A, rSmLy6B and rSmTSP7 were measured using ELISA. Read More

Parasite Immunol 2018 Sep 21:e12592. Epub 2018 Sep 21.

Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

Larvae of Schistosoma (schistosomula) are highly susceptible to host immune responses and are attractive prophylactic vaccine targets, although cellular immune responses against schistosomula antigens in endemic human populations are not well characterized. We collected blood and stool from 54 Schistosoma mansoni-infected Ugandans, isolated peripheral blood mononuclear cells and stimulated them for 24 hours with schistosome adult worm and soluble egg antigens (AWA and SEA), along with schistosomula recombinant proteins rSmKK7, Lymphocyte Antigen 6 isoforms (rSmLy6A and rSmLy6B), tetraspanin isoforms (rSmTSP6 and rSmTSP7). Cytokines, chemokines and growth factors were measured in the culture supernatants using a multiplex luminex assay, and infection intensity was determined before and at one year after praziquantel (PZQ) treatment using the Kato Katz method. Read More

Front Immunol 2018 6;9:2005. Epub 2018 Sep 6.

Department of Medicine, Center for Global Health, Weill Cornell Medicine, New York, NY, United States.

Studies of the role of co-infections on plasma HIV-1 RNA (HIV-1 viral load) have yielded incongruent results. The role of duration of HIV-1 infection on the link between and HIV-1 viral load has not been previously investigated. We aimed to assess the impact of HIV-1/ co-infections on viral load in Antiretroviral Treatment (ART)-naïve HIV-1 infected people taking into account the duration of HIV-1 infection. Read More

Travel Med Infect Dis 2018 Sep 17. Epub 2018 Sep 17.

Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.

Background: Point-of-care circulating cathodic antigen (POC-CCA) urine cassette testing has become a popular approach to screen for Schistosoma infection. Since the test is also increasingly used for following-up of treatment success, we assessed the assay's diagnostic accuracy after praziquantel treatment of S. mansoni infection among Eritrean refugees in Switzerland. Read More

PLoS Negl Trop Dis 2018 Sep 20;12(9):e0006676. Epub 2018 Sep 20.

Texas Children's Hospital Center for Vaccine Development, Departments of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.

Front Immunol 2018 31;9:1970. Epub 2018 Aug 31.

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Infection with causes a chronic parasitic disease that progress to severe liver and gastrointestinal damage, and eventually death. During its development into mammalian hosts, immature schistosomula transit through the lung vasculature before they reach the liver to mature into adult worms. A low grade inflammatory reaction is induced during this process. Read More

J Egypt Soc Parasitol 2016 Dec;46(3):693-716

Vaccination against schistosomes can be targeted towards the prevention of infection and/or to the reduction of parasite fecundity and pathology. However, as eggs are responsible mainly for schistosomiasis pathology, so crude soluble egg antigen (SEA) seems suitable to be used as a potential vaccine. Many studies have provided new insights establishing a role for mesenchymal stem cells (MSCs) in liver regeneration and improvement of schistosomiasis hepatic fibrosis, in addition to the need for standardized and effective adjuvant-vaccine formulations. Read More

J Egypt Soc Parasitol 2016 Dec;46(3):663-670

Schistosomiasis is a public health problem, in many developing: countries including Egypt, Determination of the antigenic relationship between S mansoni and its intermediate snail host (IMH) Biomphalaria alexandrina can open a new field for diagnosis and control of the dis- ease. In the present study infected and non-infected B. alexandrina foot and visceral hump tissue as well as S. Read More

J Egypt Soc Parasitol 2016 Dec;46(3):633-645

The availability of a new vaccine is usually needed as an additional component to chemotherapy for control of schistosomiasis. Different strategies of different types of vaccines were assessed to decrease morbidity but did not give the best protection. The study assessed the efficacy of BAAP, SLAP and their combined preparations together with BCG adjuvant as an effective anti-schistosomal vaccine. Read More

J Egypt Soc Parasitol 2016 Dec;46(3):485-496

Preliminary studies were carried out on schistosomiasis in Giza Governorate for the last three years. These studies revealed that Tamwah village was one of areas afflicted by the highest number of Schistosoma haematobium infection cases. 'The study assessed the epidemiological situation of S. Read More

World J Gastroenterol 2018 Sep;24(34):3927-3957

Center For the study of the Liver, Department of Hospital Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow 117198, Russia.

Aim: To provide a clear understanding of viral hepatitis epidemiology and their clinical burdens in Somalia.

Methods: A systematic review and meta-analysis was conducted as Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search of published studies on viral hepatitis was performed from 1977-2016 in PubMed, Google Scholar, Science Direct, World Health Organization African and the Africa Journals Online databases, as well as on the Ministry of Health website. Read More

Data Brief 2018 Oct 6;20:991-998. Epub 2018 Sep 6.

Uganda Institute of Allied Health & Management Science (UIAHMS), School of Medical Entomology and Parasitology, P.O. Box 1661, Kampala, Uganda.

The dataset for this article contains Urinary and Intestinal Schistosomiasis from Lango region, northern Uganda which is the only known co-endemic region for and . Reported in the data, is the retrospective data review for historical information before interventions were implemented before 2003 and after interventions were implemented in 2003 by the national control program. In 2007 and 2011, parasitological surveys were conducted in the region to validate Schistosomiasis trends following World Health Organization (WHO) guidelines for surveys. Read More

Data Brief 2018 Aug 19;19:1393-1397. Epub 2018 May 19.

Laboratório de Produtos Naturais, Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, Brazil.

In this study, the molluscicidal and antiparasitic activities of divaricatic acid was evaluated, targeting the mollusc and cercariae of the helminth . Divaricatic acid showed high toxicity against both adult snails (5.5 μg/mL) and embryos (20 μg/mL after 6 h of exposure). Read More

Int J Parasitol Drugs Drug Resist 2018 Sep 8. Epub 2018 Sep 8.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia PA 19104, USA. Electronic address:

Ion channels are membrane protein complexes that underlie electrical excitability in cells, allowing ions to diffuse through cell membranes in a regulated fashion. They are essential for normal functioning of the neuromusculature and other tissues. Ion channels are also validated targets for many current anthelmintics, yet the properties of only a small subset of ion channels in parasitic helminths have been explored in any detail. Read More

ChemMedChem 2018 Sep 13. Epub 2018 Sep 13.

Philipps-Universität Marburg, Pharmazeutische Chemie, Marbacher Weg 6, 35032, Marburg, GERMANY.

Chemotherapy based on repeated doses of Praziquantel (PZQ) is still the most effective control strategy against schistosomiasis, a neglected tropical disease caused by platyhelminths of the genus Schistosoma spp.. Its long-term use, however, raises serious concerns about drug resistance against PZQ. Read More

Gynecol Oncol Rep 2018 Nov 28;26:29-31. Epub 2018 Aug 28.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Naval Medical Center San Diego, San Diego, CA, United States.

Infectious diseases can present similar to ovarian cancer and occur concomitantly with ovarian pathology. With increased worldwide travel and migration of populations, infections endemic to developing countries can emerge in the United States. We present 2 cases of infectious diseases mimicking ovarian carcinomatosis. Read More

Parasitology 2018 Sep 13. Epub 2018 Sep 13.

Parasitology 2018 Sep 13:1-10. Epub 2018 Sep 13.

Department of Life Sciences,Natural History Museum,Cromwell Road, London SW7 5BD,UK.

Paragonimiasis, human lung fluke disease, is a foodborne anthropozoonosis caused by the trematodes assigned to Paragonimus and is regarded by the World Health Organization as a Neglected Tropical Disease (NTD). The life cycle of this medically important parasite centres on a complex freshwater biological community that includes two intermediate hosts: a mollusc and a decapod, usually a brachyuran. Although there is a perception that the biology, symptoms, diagnosis and treatment of Paragonimus is well understood, in reality, this is not the case, especially in Africa. Read More

Clin Infect Dis 2018 Sep 8. Epub 2018 Sep 8.

Immunomodulation and Vaccines Programme, Medical Research Council/ Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

Background: Allergy-related disease is increasing in low-income countries. Parasitic helminths, common in these settings, may be protective. We hypothesised that intensive community-wide anthelminthic mass drug administration (MDA) would increase allergy-related diseases, while reducing helminth-related morbidity. Read More

Int J Infect Dis 2018 Sep 7. Epub 2018 Sep 7.

Department of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Japan.

Objectives: Schistosomiasis is an important disease in Madagascar with several studies on the disease focusing on the parasite occurrence in humans. However, the range of the pathogen in the environment and its impact on human infection is difficult to predict. To improve schistosomiasis eco-epidemiology studies, an environmental DNA (eDNA) detection system for Schistosoma mansoni was developed. Read More

Parasit Vectors 2018 Sep 10;11(1):504. Epub 2018 Sep 10.

Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: Schistosoma mekongi is one of five major causative agents of human schistosomiasis and is endemic to communities along the Mekong River in southern Lao People's Democratic Republic (Laos) and northern Cambodia. Sporadic cases of schistosomiasis have been reported in travelers and immigrants who have visited endemic areas. Schistosoma mekongi biology and molecular biology is poorly understood, and few S. Read More

BMC Complement Altern Med 2018 Sep 6;18(1):247. Epub 2018 Sep 6.

Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

Background: The macerate of Sida pilosa aerial parts is used empirically for the treatment of intestinal helminthiasis. Previous studies have shown that Sida pilosa aqueous extract (SpAE) has schistosomicidal, antioxidant, anti-inflammatory and anti-fibrotic activities in Schistosoma mansoni infection. This study was designed to evaluate the effect of SpAE on the granulomatous inflammation induced by S. Read More

Parasitology 2018 Sep 6:1-4. Epub 2018 Sep 6.

Natural History Museum, Life Sciences Department, Parasites and Vectors Division,Cromwell Road, South Kensington, London SW7 5BD,UK.

Since the construction of the Diama Dam (1985), the epidemiology of schistosomiasis along the Senegal River Basin (SRB) has been extremely dynamic with outbreaks of both intestinal and urogenital schistosomiasis. In the early 2000s, technicians reported cases of suspected urogenital schistosomiasis in adults from the local hospital in Richard-Toll, Lower SRB. The genetic analysis of schistosome miracidia isolated from 11 patients in 2012 from two neighbourhoods (Campement and Gaya) of Richard-Toll confirmed infection with Schistosoma haematobium but also S. Read More

Parasit Vectors 2018 Sep 4;11(1):496. Epub 2018 Sep 4.

Department of Biology, New Mexico State University, Las Cruces, NM, USA.

Background: The aquatic pulmonate snail Biomphalaria glabrata is a significant vector and laboratory host for the parasitic flatworm Schistosoma mansoni, an etiological agent for the neglected tropical disease schistosomiasis. Much is known regarding the host-parasite interactions of these two organisms, and the B. glabrata embryonic (Bge) cell line has been an invaluable resource in these studies. Read More

Parasitol Res 2018 Sep 3. Epub 2018 Sep 3.

Shanghai Veterinary Research Institute, Key Laboratory of Animal Parasitology, Ministry of Agriculture, Chinese Academy of Agricultural Sciences, 518 Ziyue Road, Shanghai, 200241, China.

Schistosomes are the causative agents of human schistosomiasis, which is endemic in tropical and subtropical zones. CD63 is a member of the tetraspanin protein family widely expressed among eukaryotes. Previously, we identified a CD63 homolog from extracellular vesicles isolated from Schistosoma japonicum. Read More

Mol Biochem Parasitol 2018 Aug 31;225:38-46. Epub 2018 Aug 31.

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, Fujian, China; Parasitology Research Laboratory, School of Life Sciences, Xiamen University, Xiamen, 361102, Fujian, China. Electronic address:

Oncomelania hupensis is the unique intermediate host of the blood fluke Schistosoma japonicum, which causes schistosomiasis. In snails, highly toxic reactive oxygen species (ROS) can be continually generated by hemocytes in response to foreign particles or pathogens, and may be involved in damaging and eliminating digenean larvae. Thioredoxin-related protein of 14 kDa (TRP14) is a member of the Trx superfamily, and plays an important role in the scavenging of ROS. Read More

Infect Dis Poverty 2018 Sep 3;7(1):87. Epub 2018 Sep 3.

University of Montreal Public Health Research Institute (IRSPUM), Montreal, Canada.

Background: Health personnel face challenges in diagnosing vector-borne and other diseases of poverty in urban settings. There is a need to know what rapid diagnostic technologies are available, have been properly assessed, and are being implemented to improve control of these diseases in the urban context. This paper characterizes evidence on the field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of poverty. Read More

Front Med (Lausanne) 2018 10;5:223. Epub 2018 Aug 10.

Bladder Immunology Group, Biomedical Research Institute, Rockville, MD, United States.

Infection with leads to urogenital schistosomiasis, which has been correlated with the occurrence of bladder cancer. However, mechanisms responsible for this association have not yet been clearly identified. In this short review, we provide an update, highlighting the most recent studies on schistosome-associated bladder cancer, including those that focus on identifying changes in host biology during infection, as well as studies for the identification of potentially pro-carcinogenic parasite molecules, and we offer a discussion on some possible mechanisms driving schistosomal bladder cancer. Read More

Parasitology 2018 Aug 28:1-6. Epub 2018 Aug 28.

Department of Parasitology,Liverpool School of Tropical Medicine,Liverpool, L3 5QA,UK.

With the push towards control and elimination of soil-transmitted helminthiasis and schistosomiasis in low- and middle-income countries, there is a need to develop alternative diagnostic assays that complement the current in-country resources, preferably at a lower cost. Here, we describe a novel high-resolution melt (HRM) curve assay with six PCR primer pairs, designed to sub-regions of the nuclear ribosomal locus. Used within a single reaction and dye detection channel, they are able to discriminate Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Ascaris lumbricoides, Trichuris trichiuria and Schistosoma spp. Read More

Health Inf Sci Syst 2018 Dec 20;6(1). Epub 2018 Aug 20.

2Department of Computer Science, University of Illinois at Springfield, Springfield, IL USA.

Hepatic schistosomiasis is a prolonged disease resulting mainly from the solvable egg antigen of schistosomiasis infection due to the host's granulomatous cell-mediated immune. Irreversible fibrosis results from the progress of the schistosomal hepatopathy. Sensitive diagnosis of this disease is based on the investigation of the microscopy images, liver tissues, and egg identification. Read More

Acta Trop 2018 Aug 23;188:9-15. Epub 2018 Aug 23.

National Nutrition Institute, General Organization for Teaching Hospitals and Institutes, Cairo, Egypt. Electronic address:

The prevalence and intensity of Schistosoma haematobium infection was determined among schoolchildren living in five governorates in Upper Egypt. Between November 2016 and March 2017, urine samples were collected from 30,083 schoolchildren (6-16 years of age) from the governorates of Assiut (n = 7496; 6 districts), Bani Sweif (n = 4493; 7 districts), Fayoum (n = 4597; 6 districts), Menia (n = 7500; 9 districts) and Sohag (n = 5997; 11 districts). All samples were processed using urine filtration to detect and quantify S. Read More

Parasit Vectors 2018 Aug 25;11(1):481. Epub 2018 Aug 25.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.

Background: Schistosoma haematobium infection in endemic areas varies depending on the nature and complexity of the transmission networks present. Studies of micro-geographical transmission of S. haematobium infection indicate that discrepancy in prevalence between households is associated with diverse water contact behaviors and transmission that is restricted to particular sites harboring snail intermediate hosts. Read More

J Ethnopharmacol 2018 Aug 23;227:41-55. Epub 2018 Aug 23.

Department of Toxicology, School of Public Health, Peking University, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China; Key Laboratory of State Administration of Traditional Chinese Medicine for Compatibility Toxicology, Beijing 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, China. Electronic address:

Ethnopharmacological Relevance: Euphorbia semen, the dried and ripe seed of Euphorbia lathyris Linnaeus, is widely cultivated for traditional medicine use. This semen is used to expel water, help with phlegm retention, promote blood circulation, remove blood stasis, cure tinea and scabies, and treat amenorrhea, snakebites, terminal schistosomiasis, anuria and constipation.

Aim Of The Review: This review provides updated, comprehensive and categorized information on the local and traditional uses, phytochemistry, pharmacokinetics, pharmacological activities and toxicity of Euphorbia semen. Read More

Am J Trop Med Hyg 2018 Aug 20. Epub 2018 Aug 20.

University Hospital Vall d'Hebron, PROSICS Barcelona, Barcelona, Spain.

Urinary schistosomiasis causes damage to the urological system. Ultrasound is a method that detects the burden of secondary disease, individually and in epidemiological studies. In this study, the -associated urinary tract pathology is analyzed before and after treatment in a short period of time. Read More

Front Microbiol 2018 25;9:1695. Epub 2018 Jul 25.

Institute for Infectious Diseases and Vaccine Development, Tongji University School of Medicine, Shanghai, China.

Schistosomiasis japonica is one of the most prevalent parasitic diseases in China. The scarcity of effective diagnostic tools is a major factor that contributes to the high prevalence of schistosomiasis japonica. SjSP-13 is a promising serological diagnostic biomarker of the disease. Read More

Andrologia 2018 Aug 22:e13131. Epub 2018 Aug 22.

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodore Fontane, Dessau, Germany.

Congenital bilateral absence of vas deferens (CBAVD) results in obstructive azoospermia in which testicular function, such as spermatogenesis, is preserved. Bilateral testicular biopsy is not only diagnostic but also therapeutic as retrieved spermatozoa are usually cryopreserved for assisted reproduction. In this case report, CBAVD was confirmed in a 24-year-old azoospermic man on the basis of persistent azoospermia associated with low semen volume, absent fructose and normal hormonal levels, ultrasonographically (absent seminal vesicles) and histologically (intact spermatogenesis). Read More

Urologe A 2018 Aug 22. Epub 2018 Aug 22.

Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie, Universitätsklinikum Gießen und Marburg - Standort Gießen, Gießen, Deutschland.

We are observing the largest worldwide wave of migration ever. Displaced persons usually do not have access to general health care and are faced with a lack of hygienic conditions and infection control while fleeing, which leads to an accumulation of "exotic" infectious diseases. The number of patients with tuberculosis (TB) had declined for many years in Germany; however, increasing numbers of cases have recently been observed. Read More

Infect Dis Poverty 2018 Aug 23;7(1):93. Epub 2018 Aug 23.

Environment and Communication Training Unit, University Alassane Ouattara, Bouaké, Côte d'Ivoire.

After publication of this article [1] it came to our attention that Tables 2, 3, 4, 5, 6, 7 were presented incorrectly. Read More

Ann N Y Acad Sci 2018 Aug;1425(1):38-51

Center for Tropical Medicine and Infectious Diseases, Texas Tech University Health Sciences Center, Lubbock, Texas.

Schistosomiasis is of public health importance to an estimated one billion people in 79 countries. A vaccine is urgently needed. Here, we report the results of four independent, double-blind studies of an Sm-p80-based vaccine in baboons. Read More

Rev Soc Bras Med Trop 2018 Jul-Aug;51(4):546-549

Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil.

Introduction: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers.

Methods: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. Read More

Rev Inst Med Trop Sao Paulo 2018 08 20;60:e42. Epub 2018 Aug 20.

Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Parasitologia, Laboratório de Imunologia e Genômica de Parasitos, Belo Horizonte, Minas Gerais, Brazil.

Rev Inst Med Trop Sao Paulo 2018 Aug 20;60:e41. Epub 2018 Aug 20.

Universidade Federal do Ceará, Faculdade de Medicina, Programa de Pós-Graduação em Saúde Pública, Fortaleza, Ceará, Brazil.

The wide eco-bio-social intervention generated by the SaoFrancisco River Integration Project (PISF) may contribute to the dispersion or introduction of schistosomiasis intermediate hosts in areas without prior recording. The objective was to characterize the limnic malacofauna and its distribution along watersheds involved in the PISF. A cross-sectional study based on the collection of mollusks from 33 water bodies, from Aurora, Brejo Santo, Jaguaretama, Jaguaribara, Jati e Mauriti municipalities in the Ceara (CE) State was developed. Read More

PLoS One 2018 22;13(8):e0202499. Epub 2018 Aug 22.

Klinikum Wuerzburg Mitte gGmbH, Medical Mission Hospital, Dept. of Tropical Medicine, Wuerzburg, Germany.

Background: Schistosomiasis remains one of the most prevalent parasitic infections in the world and has significant economic and public health consequences, particularly in poor communities. Reliable and accurate diagnosis plays a key role in surveillance, prevention and control of schistosomiasis. Currently, the microscopic Kato Katz (KK) stool thick smear technique is the most commonly used method to diagnose Schistosoma mansoni infections in epidemiological surveys. Read More

Paediatr Int Child Health 2018 Aug 22:1-8. Epub 2018 Aug 22.

a Tropical Gastroenterology and Nutrition group , University of Zambia School of Medicine , Lusaka , Zambia.

Parasitic infections of the gut have major implications for child health, but many questions remain unanswered. Protozoal parasites, especially cryptosporidiosis and giardiasis, cause diarrhoea and contribute to impaired growth, neurocognitive development and mortality. Entamoeba histolytica causes dysentery and may have more subtle effects on child growth. Read More

Pathobiology 2018 08 21:1-9. Epub 2018 Aug 21.

Ancient Egyptian human remains have been of interest in the fields of both medical and Egyptological research for decades. However, canopic jar holders for internal organs (liver, lungs, stomach, intestines) of Egyptian mummies appear to be but a very occasional source of data for such investigations. The few medical approaches focusing on the content of these jars are summarized and listed according to pathogens and diseases to give a structured overview of this field of study. Read More

PLoS Negl Trop Dis 2018 Aug 20;12(8):e0006551. Epub 2018 Aug 20.

National Program for the Integrated Control of NTDs, Ministry of Health and Social Protection, Lomé, Togo.

Background: Togo has conducted annual, integrated, community-based mass drug administration (MDA) for soil-transmitted helminths (STH) and schistosomiasis since 2010. Treatment frequency and target populations are determined by disease prevalence, as measured by baseline surveys in 2007 and 2009, and WHO guidelines. Reported programmatic treatment coverage has averaged over 94%. Read More

Ann Thorac Med 2018 Jul-Sep;13(3):190-192

Department of Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.

is a parasitic infection that affects many people worldwide. However, pulmonary Schistosomiasis is very rare entity which defined as pulmonary involvement develops in persons living or travelling in endemic areas. We report a rare case of 23-year-old Yamani patient admitted as an emergency with a 1-week history of productive cough, hemoptysis, and chest pain. Read More

Int J Nanomedicine 2018 6;13:4493-4505. Epub 2018 Aug 6.

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt,

Purpose: Lipid nanocapsules (LNCs) have shown potential to increase the bioavailability and efficacy of orally administered drugs. However, their intestinal translocation to distal target sites and their implication in pharmacokinetic (PK)-pharmacodynamic (PD) relationships are yet to be elucidated. In this study, the effect of LNCs on the PD activity and pharmacokinetics of praziquantel (PZQ), the mainstay of schistosomiasis chemotherapy, was investigated. Read More

Dose Response 2018 Jul-Sep;16(3):1559325818790869. Epub 2018 Aug 9.

Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Background: Copper is an essential element that is used widely in agriculture as fungicides and insecticides; for example, it is used to control schistosomiasis and as an antiseptic and germicide. Copper sulfate (CuSO) induces multiorgan dysfunction through the stimulation of reactive oxygen species and oxidative stress. Despite the numerous pharmacological effects of curcumin (CUR), its pharmacokinetic properties are less promising. Read More