25,834 results match your criteria Schistosomiasis

Prevalence and intensity of infection among schoolchildren in central Zambia before and after mass treatment with a single dose of praziquantel.

Trop Parasitol 2018 Jan-Jun;8(1):12-17. Epub 2018 May 28.

Department of Chemistry, School of Natural Sciences, The University of Zambia, Zambia, United Kingdom.

Introduction: Urinary schistosomiasis caused by is common in some parts of Lusaka Province, Zambia, where water contact activity is high and sanitation is poor. We conducted a longitudinal study in Ng'ombe Compound of Lusaka, between 2007 and 2015, to observe the prevalence and intensity of infection among community primary school children, before and after receiving a single dose of praziquantel.

Materials And Methods: A total of 975 (445 females and 530 males) pupils, aged 9-16 years, were tested for at baseline. Read More

View Article

Extending the global worm index and its links to human development and child education.

PLoS Negl Trop Dis 2018 06 21;12(6):e0006322. Epub 2018 Jun 21.

Center for Health & Biosciences, James A. Baker III Institute for Public Policy, Rice University, Houston, Texas, United States of America.

View Article

Octopamine-signaling in the metazoan pathogen, : localization, small-molecule screening and opportunities for drug development.

Dis Model Mech 2018 Jun 20. Epub 2018 Jun 20.

Institute of Parasitology, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Quebec H9X-3V9, Canada.

Schistosomiasis is a tropical disease caused by a flatworm trematode parasite that infects over 240 million people worldwide. Treatment and control of the disease rely on just one drug, praziquantel. The possibility of drug resistance coupled with praziquantel's variable efficacy encourages the identification of new drugs and drug targets. Read More

View Article

Structure⁻Activity Relationship of Piplartine and Synthetic Analogues against and Cytotoxicity to Mammalian Cells.

Int J Mol Sci 2018 Jun 19;19(6). Epub 2018 Jun 19.

Núcleo de Pesquisa em Biodiversidade e Biotecnologia, Biotec, Universidade Federal do Piauí, UFPI, Parnaíba-PI, 64202-020 Brazil.

Schistosomiasis, caused by helminth flatworms of the genus , is an infectious disease mainly associated with poverty that affects millions of people worldwide. Since treatment for this disease relies only on the use of praziquantel, there is an urgent need to identify new antischistosomal drugs. Piplartine is an amide alkaloid found in several species (Piperaceae) that exhibits antischistosomal properties. Read More

View Article

Field and laboratory comparative evaluation of a LAMP assay for the diagnosis of urogenital schistosomiasis in Cubal, Central Angola.

Trop Med Int Health 2018 Jun 19. Epub 2018 Jun 19.

Infectious and Tropical Diseases Research Group (e-INTRO), Biomedical Research Institute of Salamanca-Research Centre for Tropical Diseases at the University of Salamanca (IBSAL-CIETUS), Faculty of Pharmacy, University of Salamanca, Salamanca, Spain.

Objective: To evaluate the performance of Rapid-Heat LAMPellet assay in field conditions for diagnosis of urogenital schistosomiasis in an endemic area in Cubal, Angola and to assess the reproducibility in a reference laboratory.

Methods: A total of 172 urine samples from school age children were tested for microhaematuria, microscopic detection of S. haematobium eggs and LAMP for DNA detection. Read More

View Article

New Approach for Controlling Snail Host of Schistosoma mansoni, Biomphalaria alexandrina with Cyanobacterial Strains-Derived C-Phycocyanin.

Vector Borne Zoonotic Dis 2018 Jun 19. Epub 2018 Jun 19.

4 Department of Zoonoses, Faculty of Veterinary Medicine, Zagazig University , Zagazig, Egypt .

Schistosomiasis is one of the major communicable diseases of public health and socioeconomic importance in the developing world. It is a waterborne disease in which Biomphalaria alexandrina snails are known to be the intermediate molluscan host for Schistosoma mansoni: the causative agent of human intestinal schistosomiasis. Therefore, snail control is one of the cornerstones of schistosomiasis control programs. Read More

View Article

Schistosomiasis in immigrants, refugees and travellers in an Italian referral centre for tropical diseases.

Infect Dis Poverty 2018 Jun 16;7(1):55. Epub 2018 Jun 16.

Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital, Via Sempreboni 5, 37024, Negrar, Italy.

Background: Schistosomiasis is one of the most important neglected tropical diseases. If unrecognised and untreated, the chronic infection can lead to irreversible complications.

Methods: Retrospective observational study aimed at describing clinical history, laboratory findings and imaging presentation of imported schistosomiasis diagnosed at the Centre for Tropical Diseases, Sacro Cuore Don Calabria Hospital of Negrar, Verona, Italy from 2010 to 2014. Read More

View Article

Time series model for forecasting the number of new admission inpatients.

BMC Med Inform Decis Mak 2018 Jun 15;18(1):39. Epub 2018 Jun 15.

Department of Information, Research Institute of Field Surgery, Daping Hospital of Army Medical University, 10 Changjiang Access Road, Chongqing, 400042, China.

Background: Hospital crowding is a rising problem, effective predicting and detecting managment can helpful to reduce crowding. Our team has successfully proposed a hybrid model combining both the autoregressive integrated moving average (ARIMA) and the nonlinear autoregressive neural network (NARNN) models in the schistosomiasis and hand, foot, and mouth disease forecasting study. In this paper, our aim is to explore the application of the hybrid ARIMA-NARNN model to track the trends of the new admission inpatients, which provides a methodological basis for reducing crowding. Read More

View Article

Establishing the Production of Male Schistosoma mansoni Cercariae for a Controlled Human Infection Model.

J Infect Dis 2018 Jun 13. Epub 2018 Jun 13.

Department of Parasitology, Leiden University Medical Center, the Netherlands.

To accelerate the development of novel vaccines for schistosomiasis, we set out to develop a human model for Schistosoma mansoni infection in healthy volunteers. During natural infections, female schistosomes produce eggs that give rise to morbidity. Therefore, we produced single-sex, male Schistosoma mansoni cercariae for human infection without egg production and associated pathology. Read More

View Article

A single dose of the antineoplastics hydroxyurea or cisplatin has praziquantel-like effects on Schistosoma mansoni worms and host mouse liver.

Biomed Pharmacother 2018 Mar 20;99:570-575. Epub 2018 Feb 20.

Zoology Department, Faculty of Science, Damietta University, New Damietta 34517, Egypt. Electronic address:

Increasing resistance to praziquantel, the only available antischistosomal drug, is always developed by schistosomes. The recent description of stem cell-like neoblasts in schistosomes led to the idea of applying antineoplastic drugs as antischistosomal agents that may inhibit stem cell divisions and retard worm regeneration. Here, we explored the in vitro and in vivo effect of some antineoplastic drugs on S. Read More

View Article

Strongyloides stercoralis: the need for accurate information - Authors' reply.

Lancet 2018 Jun;391(10137):2323

The Task Force for Global Health, Decatur, GA, USA; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.

View Article

BgTEP: An Antiprotease Involved in Innate Immune Sensing in .

Front Immunol 2018 29;9:1206. Epub 2018 May 29.

Université de Perpignan Via Domitia, Interactions Hôtes Pathogènes Environnements UMR 5244, CNRS, IFREMER, Université de Montpellier, Perpignan, France.

Insect thioester-containing protein (iTEP) is the most recently defined group among the thioester-containing protein (TEP) superfamily. TEPs are key components of the immune system, and iTEPs from flies and mosquitoes were shown to be major immune weapons. Initially characterized from insects, TEP genes homologous to iTEP were further described from several other invertebrates including arthropods, cniderians, and mollusks albeit with few functional characterizations. Read More

View Article
May 2018
1 Read

Antischistosomal Properties of Hederacolchiside A1 Isolated from .

Molecules 2018 Jun 13;23(6). Epub 2018 Jun 13.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala 75105, Sweden.

: Schistosomiasis is a major neglected disease for which the current control strategy involves mass treatment with praziquantel, the only available drug. Hence, there is an urgent need to develop new antischistosomal compounds. : The antischistosomal activity of hederacolchiside A1 (HSA) were determined by total or female worm burden reductions in mice harboring or . Read More

View Article

An Integrated Approach to Control Soil-Transmitted Helminthiasis, Schistosomiasis, Intestinal Protozoa Infection, and Diarrhea: Protocol for a Cluster Randomized Trial.

JMIR Res Protoc 2018 Jun 12;7(6):e145. Epub 2018 Jun 12.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: The global strategy to control helminthiases (schistosomiasis and soil-transmitted helminthiasis) emphasizes preventive chemotherapy. However, in the absence of access to clean water, improved sanitation, and adequate hygiene, reinfection after treatment can occur rapidly. Integrated approaches might be necessary to sustain the benefits of preventive chemotherapy and make progress toward interruption of helminthiases transmission. Read More

View Article

Mass Drug Administration Regimens and Their Effect on Morbidity among Schoolchildren over a 5-Year Period-Kenya, 2010-2015.

Am J Trop Med Hyg 2018 Jun 11. Epub 2018 Jun 11.

Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.

Schistosomiasis control programs are designed to reduce morbidity by providing mass drug administration (MDA) of praziquantel to at-risk populations. We compared morbidity markers between two cohorts of Kenyan schoolchildren that initially had high prevalence of infections. One cohort ( = 416 at year 1) received four rounds of annual MDA in a community-wide treatment (CWT) strategy. Read More

View Article

The comparative efficacy of renin-angiotensin system blockers in schistosomal hepatic fibrosis.

Exp Parasitol 2018 Jun 8;191:9-18. Epub 2018 Jun 8.

Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Brazil. Electronic address:

Schistosomiasis mansoni is involved in hepatic fibrogenesis and portal hypertension. Previous studies proved that blockade of some components of the renin-angiotensin system (RAS) reduce liver fibrogenesis. However, the effects of inhibition of early stages of RAS pathway in schistosomal fibrosis have not been studied yet. Read More

View Article

Post-transplant liver graft schistosomiasis in a migrant from Sub-Saharan Africa, Italy 2017.

Transpl Infect Dis 2018 Jun 11:e12950. Epub 2018 Jun 11.

Department of Translational Research, N.T.M.S., University of Pisa, Via Roma 55, 56126, Pisa, Italy.

We report a case of post-transplant liver graft infection with Schistosoma spp in a migrant from Sub-Saharan Africa transplanted for HBV-related cirrhosis and with undiagnosed schistosomiasis pre-transplantation. The occurrence of tropical diseases in non-endemic areas warrants screening protocols for organ donors and recipients with a history of exposure in endemic areas. This article is protected by copyright. Read More

View Article

Isolation and Characterization of Extracellular Vesicles from Adult Schistosoma japonicum.

J Vis Exp 2018 05 22(135). Epub 2018 May 22.

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture;

Extracellular vesicles (EVs) are membranous vesicles released by a variety of cells into the extracellular microenvironment. EVs represent a population of heterogeneous vesicles, whose size range between 40 and 1,000 nm. Accumulated evidence indicated that EVs play important regulatory roles in pathogen-host interactions. Read More

View Article

A rare cause of diarrhea in the occident: A case of colonic schistosomiasis.

Clin Res Hepatol Gastroenterol 2018 Jun 7. Epub 2018 Jun 7.

Gastroenterology Department, Hospital Professor Doutor Fernando Fonseca, IC 19, 2720-276 Amadora, Lisboa, Portugal.

View Article

Multivariate analysis of factors associated with and hookworm infection among primary school children in rural Bahir Dar, Northwest Ethiopia.

Trop Dis Travel Med Vaccines 2018 1;4. Epub 2018 Jun 1.

1Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, Ethiopia.

Background: Soil-transmitted helminths and infections are the major causes of morbidity and mortality in Sub-Saharan countries. The highest burden of the disease resides in school-age children. Poor water sanitation and hygiene are believed to be the major contributing factors for the high prevalence. Read More

View Article

Serine/threonine protein phosphatase 1 (PP1) controls growth and reproduction in Schistosoma japonicum.

FASEB J 2018 Jun 7:fj201800725R. Epub 2018 Jun 7.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

Schistosomiasis is a human parasitic disease caused by flatworms of the genus Schistosoma. Adult female schistosomes produce numerous eggs that are responsible for the pathogenesis and transmission of the disease, and the maturation of female gonads depends on the permanent pairing of females and males. Signaling protein kinases have been proven to control female gonad differentiation after pairing; however, little is known about the roles of protein phosphatases in the developmental and reproductive biology of schistosomes. Read More

View Article

Dataset on usnic acid from Vainio (Lichen) schistosomiasis mansoni's vector control and environmental toxicity.

Data Brief 2018 Apr 3;17:288-291. Epub 2018 Jan 3.

Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Av. da Engenharia, S/N, Cidade Universitária, CEP 50670-420 Recife, PE, Brazil.

This text presents complementary data corresponding to schistosomiasis mansoni's vector control and enviromental toxicity using usnic acid. These informations support our research article "Toxicity of Usnic Acid from (Lichen) to embryos and adults of " by Araújo et al. [1], and focuses on the analysis of the detailed data regarding the different concentrations of Usnic Acid and their efficiency to mortality and non-viability, as also to environmental toxicity, evaluated by mortality. Read More

View Article

Arsenicosis in bladder pathology and schistosomiasis in Eggua, Nigeria.

Trans R Soc Trop Med Hyg 2018 Jun 2. Epub 2018 Jun 2.

Department of Zoology, University of Ibadan, Ibadan.

Background: Chronic schistosomiasis and arsenic exposure through drinking water are some of the risk factors for bladder cancer. To determine the association of schistosomiasis and arsenicosis with bladder pathologies, 122 individuals from Eggua in southwest Nigeria were recruited for this study.

Methods: Prevalence of schistosomiasis was determined by urine microscopy and PCR. Read More

View Article

Adventure tourism and schistosomiasis: serology and clinical findings in a group of Danish students after white-water rafting in Uganda.

JMM Case Rep 2018 Apr 2;5(4):e005141. Epub 2018 Feb 2.

Laboratory of Parasitology, Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark.

Introduction: Diagnosis of schistosomiasis in travellers is a clinical challenge, since cases may present with no symptoms or a few non-specific symptoms. Here, we report on the laboratory and clinical findings in Danish travellers exposed to -infested water during white-water rafting on the Ugandan part of the upper Nile River in July 2009.

Case Presentation: Forty travellers were offered screening for -specific antibodies. Read More

View Article

Pharmacokinetics of praziquantel in and infected school- and preschool- aged children.

Antimicrob Agents Chemother 2018 Jun 4. Epub 2018 Jun 4.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland

There is a growing consensus to include preschool-aged children in preventive chemotherapy programs with praziquantel, aiming to control schistosomiasis. However, pharmacokinetic data, crucial to establish safe and effective dose for this age group, are sparse. The objective of this study was to establish and compare pharmacokinetic parameters of praziquantel in schistosomiasis infected preschool- and school-aged children. Read More

View Article
June 2018
1 Read

Improving spatial prediction of Schistosoma haematobium prevalence in southern Ghana through new remote sensors and local water access profiles.

PLoS Negl Trop Dis 2018 Jun 4;12(6):e0006517. Epub 2018 Jun 4.

Department of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts, United States of America.

Background: Schistosomiasis is a water-related neglected tropical disease. In many endemic low- and middle-income countries, insufficient surveillance and reporting lead to poor characterization of the demographic and geographic distribution of schistosomiasis cases. Hence, modeling is relied upon to predict areas of high transmission and to inform control strategies. Read More

View Article
June 2018
3 Reads

The burden of Neglected Tropical Diseases in Brazil, 1990-2016: A subnational analysis from the Global Burden of Disease Study 2016.

PLoS Negl Trop Dis 2018 06 4;12(6):e0006559. Epub 2018 Jun 4.

Institute of Studies in Public Health, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Neglected Tropical Diseases (NTDs) are important causes of morbidity, disability, and mortality among poor and vulnerable populations in several countries worldwide, including Brazil. We present the burden of NTDs in Brazil from 1990 to 2016 based on findings from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016).

Methodology: We extracted data from GBD 2016 to assess years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) for NTDs by sex, age group, causes, and Brazilian states, from 1990 to 2016. Read More

View Article
June 2018
3 Reads

Are We on Our Way to Achieving the 2020 Goals for Schistosomiasis Morbidity Control Using Current World Health Organization Guidelines?

Clin Infect Dis 2018 Jun;66(suppl_4):S245-S252

London Centre for Neglected Tropical Disease Research, Imperial College London, United Kingdom.

Background: Schistosomiasis remains an endemic parasitic disease affecting millions of people around the world. The World Health Organization (WHO) has set goals of controlling morbidity to be reached by 2020, along with elimination as a public health problem in certain regions by 2025. Mathematical models of parasite transmission and treatment impact have been developed to assist in controlling the morbidity caused by schistosomiasis. Read More

View Article
June 2018
1 Read

Urogenital Schistosomiasis among Schoolchildren and the Associated Risk Factors in Selected Rural Communities of Kwara State, Nigeria.

J Trop Med 2018 2;2018:6913918. Epub 2018 May 2.

Department of Zoology, University of Ilorin, Ilorin, Nigeria.

Urogenital schistosomiasis is a chronic parasitic disease that causes severe morbidity among schoolchildren in many poor-resource communities in Nigeria. We investigated the prevalence, intensity, and risk factors of the infection in three communities of Kwara State to ascertain the current status of the disease. Of the 724 urine samples screened, using filtration method, 332 (45. Read More

View Article

A Rapid Public Health Needs Assessment Framework for after Major Earthquakes Using High-Resolution Satellite Imagery.

Int J Environ Res Public Health 2018 May 30;15(6). Epub 2018 May 30.

Chinese Center for Disease Control and Prevention, Beijing 102206, China.

: Earthquakes causing significant damage have occurred frequently in China, producing enormous health losses, damage to the environment and public health issues. Timely public health response is crucial to reduce mortality and morbidity and promote overall effectiveness of rescue efforts after a major earthquake. : A rapid assessment framework was established based on GIS technology and high-resolution remote sensing images. Read More

View Article

Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011.

PLoS One 2018 30;13(5):e0197770. Epub 2018 May 30.

Department of Infectious Diseases, Public Health Service (GGD), Amsterdam, the Netherlands.

Background: Despite the considerable burden of helminth infections in developing countries and increasing international travel, little is known about the risks of infection for travelers.

Objective: We studied the attack and incidence rate of serology confirmed strongyloidiasis, filariasis, and toxocariasis among long-term travelers and associated factors. A second objective was to evaluate eosinophilia as a positive/negative predictive value (PPV/NPV) for a recent helminth infection. Read More

View Article

Therapeutic potential effect of bone marrow-derived mesenchymal stem cells on chronic liver disease in murine .

J Parasit Dis 2018 Jun 23;42(2):277-286. Epub 2018 Apr 23.

4Department of Anatomy & Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

Some reports have shown that mesenchymal stem cells (MSCs) therapy could ameliorate chemically-induced hepatic fibrosis. This research assesses the therapeutic action of bone marrow mesenchymal stem cells (BM-MSCs) on chronic diseased liver in infected mice. All infected female mice divided into three groups, one group (15 mice) treated with oral praziquantel (PZQ), second group (15 mice) received intravenous injection of BM-MSCs and third group (15 mice) treated with both MSCs + PZQ. Read More

View Article

The small RNA complement of adult Schistosoma haematobium.

PLoS Negl Trop Dis 2018 05 29;12(5):e0006535. Epub 2018 May 29.

Melbourne Veterinary School, Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Background: Blood flukes of the genus Schistosoma cause schistosomiasis-a neglected tropical disease (NTD) that affects more than 200 million people worldwide. Studies of schistosome genomes have improved our understanding of the molecular biology of flatworms, but most of them have focused largely on protein-coding genes. Small non-coding RNAs (sncRNAs) have been explored in selected schistosome species and are suggested to play essential roles in the post-transcriptional regulation of genes, and in modulating flatworm-host interactions. Read More

View Article

Prediction of the potential global distribution for Biomphalaria straminea, an intermediate host for Schistosoma mansoni.

PLoS Negl Trop Dis 2018 05 29;12(5):e0006548. Epub 2018 May 29.

Key Laboratory of Public Health Safety, Ministry of Education, Tropical Disease Research Center, Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.

Background: Schistosomiasis is a snail-borne parasitic disease and is endemic in many tropical and subtropical countries. Biomphalaria straminea, an intermediate host for Schistosoma mansoni, is native to the southeastern part of South America and has established in other regions of South America, Central America and southern China during the last decades. S. Read More

View Article

Whole genome amplification and exome sequencing of archived schistosome miracidia.

Parasitology 2018 May 28:1-9. Epub 2018 May 28.

Department of Genetics,Texas Biomedical Research Institute,PO Box 760549, San Antonio, TX 78245-0549,USA.

Adult schistosomes live in the blood vessels and cannot easily be sampled from humans, so archived miracidia larvae hatched from eggs expelled in feces or urine are commonly used for population genetic studies. Large collections of archived miracidia on FTA cards are now available through the Schistosomiasis Collection at the Natural History Museum (SCAN). Here we describe protocols for whole genome amplification of Schistosoma mansoni and Schistosome haematobium miracidia from these cards, as well as real time PCR quantification of amplified schistosome DNA. Read More

View Article

Synthesis, crystallization studies and in vitro characterization of novel cinnamic acid derivatives as SmHDAC8 inhibitors for the treatment of Schistosomiasis.

ChemMedChem 2018 May 27. Epub 2018 May 27.

Martin-Luther-Universit�t Halle-Wittenberg, Department of Pharmaceutical Chemistry, Wolfgang-Langenbeck-Str. 4, 6120, Halle Saale, GERMANY.

Schistosomiasis is a neglected parasitic disease that affects more than 265 million people worldwide and for which the control strategy relies on mass treatment with only one drug, praziquantel. Based on the 3-chlorobenzothiophene-2-hydroxamic acid J1075, a series of hydroxamic acids with different scaffolds was prepared as potential inhibitors of Schistosoma mansoni histone deacetylase 8 (SmHDAC8). The crystal structures of SmHDAC8 with four inhibitors provided insights into the binding mode and orientation of molecules in the binding pocket as well as the orientation of its flexible amino acid residues. Read More

View Article

Calmodulins from Schistosoma mansoni: Biochemical analysis and interaction with IQ-motifs from voltage-gated calcium channels.

Cell Calcium 2018 May 17;74:1-13. Epub 2018 May 17.

School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK; Institute for Global Food Security, Queen's University Belfast, 18-30 Malone Road, Belfast BT9 5BN, UK; School of Pharmacy and Biomolecular Sciences, University of Brighton, Huxley Building, Lewes Road, Brighton BN2 4GJ, UK. Electronic address:

The trematode Schistosoma mansoni is a causative agent of schistosomiasis, the second most common parasitic disease of humans after malaria. Calcium homeostasis and calcium-mediated signalling pathways are of particular interest in this species. The drug of choice for treating schistosomiasis, praziquantel, disrupts the regulation of calcium uptake and there is interest in exploiting calcium-mediated processes for future drug discovery. Read More

View Article
May 2018
4 Reads

Treating schistosomiasis among South African high school pupils in an endemic area, a qualitative study.

BMC Infect Dis 2018 May 25;18(1):239. Epub 2018 May 25.

Discipline of Public Health Medicine, Howard College Campus, University of KwaZulu-Natal, Room 219, George Campbell Building, Science Drive, Durban, 4001, South Africa.

Background: Schistosomiasis, a neglected tropical disease caused by parasites that infest open water sources such as rivers and dams may increase susceptibility to HIV. Mass-treatment with praziquantel tablets, recommended by the World Health Organization reduces the prevalence of schistosomiasis. The goal in endemic areas is 75% treatment participation in every treatment round (e. Read More

View Article

Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.

ACS Chem Biol 2018 Jun 11. Epub 2018 Jun 11.

Department of Life, Health and Environmental Sciences , University of L'Aquila , 67100 L'Aquila , Italy.

Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases. However, individual FAD/NAD reductases are difficult to inhibit in a selective manner with off-target inhibition reducing usefulness of identified compounds. Thioredoxin glutathione reductase (TGR), a high molecular weight thioredoxin reductase-like enzyme, has emerged as a promising drug target for the treatment of schistosomiasis, a parasitosis afflicting more than 200 million people. Read More

View Article

"Rapid impact" 10 years after: The first "decade" (2006-2016) of integrated neglected tropical disease control.

PLoS Negl Trop Dis 2018 05 24;12(5):e0006137. Epub 2018 May 24.

Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

View Article

Giant pulmonary artery aneurysm in a patient with schistosomiasis-associated pulmonary arterial hypertension.

J Bras Pneumol 2018 Apr;44(2):167

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

View Article

Negligible import of enteric pathogens by newly-arrived asylum seekers and no impact on incidence of notified and infections and outbreaks in Rhineland-Palatinate, Germany, January 2015 to May 2016.

Euro Surveill 2018 May;23(20)

Department of Infectious Diseases, Medical Microbiology and Hygiene, University Hospitals, Heidelberg, Germany.

IntroductionThe 2015 refugee crisis raised concerns about an import of infectious diseases affecting the German population. To evaluate public and individual health benefits of stool screening, and explore whether importation of enteric pathogens by newly-arrived asylum seekers impacts on the host population. : We used data from mandatory stool screening to determine the overall, age, sex, and country-specific prevalence of enteric bacteria and helminths. Read More

View Article
May 2018
2 Reads

Illnesses Associated with Freshwater Recreation During International Travel.

Curr Infect Dis Rep 2018 May 22;20(7):19. Epub 2018 May 22.

Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

Purpose Of Review: International travel, adventure travel, and eco-tourism are increasing over the past few decades. This review aims to summarize the spectrum of infections associated with recreational freshwater activities and international travel.

Recent Findings: Recreational water activities can be associated with a wide range of infections. Read More

View Article

Tools for Detection of Schistosomiasis in Resource Limited Settings.

Med Sci (Basel) 2018 May 23;6(2). Epub 2018 May 23.

Biotechnology Division, National Veterinary Research Institute, P.M.B. 001, Vom, Jos, 930281, Plateau State, Nigeria.

Schistosomiasis is a debilitating disease affecting over 200 million people, with the highest burden of morbidity and mortality in African countries. Despite its huge impact on the health and socio-economic burden of the society, it remains a neglected tropical disease, with limited attention from governments and stakeholders in healthcare. One of the critical areas that is hugely under-developed is the development of accurate diagnostics for both intestinal and urogenital schistosomiasis. Read More

View Article
May 2018
1 Read

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni.

PLoS Pathog 2018 05 21;14(5):e1007066. Epub 2018 May 21.

Univ. Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, Perpignan, France.

Epigenetic mechanisms and chromatin structure play an important role in development. Their impact is therefore expected to be strong in parasites with complex life cycles and multiple, strikingly different, developmental stages, i.e. Read More

View Article

The human-snail transmission environment shapes long term schistosomiasis control outcomes: Implications for improving the accuracy of predictive modeling.

PLoS Negl Trop Dis 2018 05 21;12(5):e0006514. Epub 2018 May 21.

Center for Global Health and Diseases, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.

Introduction: Schistosomiasis is a chronic parasitic trematode disease that affects over 240 million people worldwide. The Schistosoma lifecycle is complex, involving transmission via specific intermediate-host freshwater snails. Predictive mathematical models of Schistosoma transmission have often chosen to simplify or ignore the details of environmental human-snail interaction in their analyses. Read More

View Article

Parasitic Infections in Individuals Travelling to America and Precautionary Measures.

Turkiye Parazitol Derg 2018 Mar;42(1):81-89

Ege Üniversitesi Tıp Fakültesi, Parazitoloji Anabilim Dalı, İzmir, Türkiye.

Over the past decade, the number of international travels has increased. Hence, the risk of transmission of parasitic diseases has also increased. One of the risk infections is malaria; Plasmodium vivax and P. Read More

View Article

Parasitic Diseases that can Infect Travelers to Africa.

Turkiye Parazitol Derg 2018 May 21. Epub 2018 May 21.

Ege Üniversitesi Tıp Fakültesi, Parazitoloji Anabilim Dalı, İzmir, Türkiye.

Travel is important in the spread of diseases, and the number of travelers is increasing daily. Therefore, the importance of the diseases that occur during or after travel is increasing. In underdeveloped countries in particular, parasitic diseases are epidemic or endemic, and these diseases lead to high numbers of deaths. Read More

View Article

Efficacy of artemisinin-naphthoquine phosphate against Schistosoma haematobium adult flukes: dose-effect relationship and tegumental alterations.

J Helminthol 2018 May 21:1-6. Epub 2018 May 21.

Department of Medical Parasitology,Faculty of Medicine,Mansoura University,Mansoura 35516-Egypt.

Schistosoma haematobium and Schistosoma mansoni infections have broadly overlapping geographical distributions. Praziquantel is the only treatment for human schistosomiasis, so drug tolerance and/or resistance are major concerns. Artemisinin-naphthoquine phosphate (CO-ArNp), an artemisinin-based combination therapy endorsed by the World Health Organization as a gold standard therapy for malaria, has also been identified as a promising treatment for S. Read More

View Article

Health issues of refugees attending an infectious disease refugee health clinic in a regional Australian hospital

Aust J Gen Pract 2018 05;47(5):305-310

MBBS, FRACP, MD, MPH, Department of Infectious Diseases, Barwon Health, Geelong, Vic.

Background And Objectives: Refugees in Australia present with conditions different to those of the general population. The aim of this study was to review the reasons for referral, prevalence of conditions and treatment outcomes for refugee patients attending a specialist referral clinic in regional Victoria.

Method: A retrospective review was undertaken of patients attending the refugee health clinic at University Hospital Geelong from January 2007 to December 2012. Read More

View Article