26,444 results match your criteria Schistosomiasis


Field Testing Integrated Interventions for Schistosomiasis Elimination in the People's Republic of China: Outcomes of a Multifactorial Cluster-Randomized Controlled Trial.

Front Immunol 2019 3;10:645. Epub 2019 Apr 3.

Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Despite significant progress, China faces the challenge of re-emerging schistosomiasis transmission in currently controlled areas due, in part, to the presence of a range of animal reservoirs, notably water buffalo and cattle, which can harbor infections. Environmental, ecological and social-demographic changes in China, shown to affect the distribution of oncomelanid snails, can also impact future schistosomiasis transmission. In light of their importance in the , lifecycle, vaccination has been proposed as a means to reduce the excretion of egg from cattle and buffalo, thereby interrupting transmission from these reservoir hosts to snails. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456715PMC
April 2019
1 Read

Evaluation of the schistosomicidal, antioxidant and anti-inflammatory activities of the ethyl acetate fraction from Ozoroa pulcherrima Schweinf. Roots on Schistosoma mansoni-induced liver pathology in mice and its phytochemical characterization.

J Ethnopharmacol 2019 Apr 15:111883. Epub 2019 Apr 15.

Laboratory of Biology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon; Centre for Schistosomiasis and Parasitology, P.O. Box 7244, Yaoundé, Cameroon. Electronic address:

Ethnopharmacological Relevance: Ozoroa pulcherrima Schweinf. (syn.: Heeria pulcherrrima Schweinf. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111883DOI Listing
April 2019
1 Read

Schistosomiasis mansoni in the northeast region of brazil: temporal modeling of positivity, hospitalization,and mortality rates.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180458. Epub 2019 Apr 11.

Departamento de Medicina, Campus Arapiraca, Universidade Federal de Alagoas, Arapiraca, AL, Brasil.

Introduction: We aimed to analyze trends in Schistosomiasis positivity, mortality, and hospitalization rates in Northeast Brazil.

Methods: We conducted an ecological study using data from the Brazilian Schistosomiasis Control Program, and Hospital and Mortality Information Systems. A joinpoint regression model was used for temporal analysis. Read More

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http://dx.doi.org/10.1590/0037-8682-0458-2018DOI Listing

Infection as a Predictor of Low Aerobic Capacity in Ugandan Children.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Using the 20-meter shuttle run test (20mSRT) as a morbidity metric, we assessed whether infection was associated with decreased aerobic capacity in Ugandan children across a range of altitudes, either at low (∼600 m) or high (∼1,000 m) altitudes. A total of 305 children were recruited from six schools within the Buliisa District, Lake Albert, Uganda. A subset ( = 96) of these had been previously assessed and treated for schistosomiasis ± malaria 2 weeks prior. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0922
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http://dx.doi.org/10.4269/ajtmh.18-0922DOI Listing
April 2019
2 Reads

Eugenol, a potential schistosomicidal agent with anti-inflammatory and antifibrotic effects against induced liver pathology.

Infect Drug Resist 2019 28;12:709-719. Epub 2019 Mar 28.

Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia.

Introduction: Schistosomiasis is one of the most prevalent parasitic infections in developing countries. Although chemotherapy is one of the main strategies in controlling the disease, it is less effective in reversal of schistosome-induced pathology especially in the chronic and advanced stages of schistosomiasis. New strategies and prospective therapeutic agents with antifibrotic effects are needed. Read More

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https://www.dovepress.com/eugenol-a-potential-schistosomicid
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http://dx.doi.org/10.2147/IDR.S196544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445185PMC
March 2019
1 Read

Qualitative and quantitative proteomic analyses of Schistosoma japonicum eggs and egg-derived secretory-excretory proteins.

Parasit Vectors 2019 Apr 16;12(1):173. Epub 2019 Apr 16.

School of Veterinary Science, The University of Queensland, Brisbane, QLD, Australia.

Background: Schistosome parasites lay up to a thousand eggs per day inside the veins of their mammalian hosts. The immature eggs deposited by females against endothelia of venules will embryonate within days. Approximately 30% of the eggs will migrate to the lumen of the intestine to continue the parasite life-cycle. Read More

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http://dx.doi.org/10.1186/s13071-019-3403-1DOI Listing
April 2019
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Effect of high-intensity versus low-intensity praziquantel treatment on HIV disease progression in HIV and co-infected patients: a randomised controlled trial.

Wellcome Open Res 2018 3;3:81. Epub 2019 Apr 3.

MRC UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda.

It has been hypothesised that co-infection exacerbates HIV progression, and hence anthelminthic intervention in co-infected individuals will delay it. We evaluated effects of high-intensity versus low-intensity praziquantel treatment of schistosomiasis on HIV disease progression among co-infected patients from fishing populations around Lake Victoria, Uganda. : Between August 2012 and September 2015, we conducted an open-label randomised, controlled trial. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.14683.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241569.2PMC
April 2019
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A comparison of ancient parasites as seen from archeological contexts and early medical texts in China.

Int J Paleopathol 2019 Apr 12;25:30-38. Epub 2019 Apr 12.

Institute of Archaeology, Chinese Academy of Social Sciences, Beijing, 100732, China.

This paper integrates our knowledge from traditional Chinese medical texts and archeological findings to discuss parasitic loads in early China. Many studies have documented that several different species of eukaryotic endoparasites were present in early human populations throughout China. Nevertheless, comprehensive paleoparasitological records from China are patchy, largely due to taphonomic and environmental factors. Read More

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http://dx.doi.org/10.1016/j.ijpp.2019.03.004DOI Listing
April 2019
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The soluble worm antigens-specific antibodies used as biomarkers of Schistosoma japonicum in a low prevalence and intensity endemic area of Hubei, China.

Acta Trop 2019 Apr 12. Epub 2019 Apr 12.

Division of Gastroenterology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China. Electronic address:

The precise diagnosis of Schistosoma japonicum (S. japonicum) infection plays a critical role in achieving the ultimate goal of eliminating schistosomiasis in endemic regions. We evaluated the S. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.04.011DOI Listing

Primary Membranous Glomerulonephritis-associated with Schistosomal Nephropathy.

Indian J Nephrol 2019 Mar-Apr;29(2):140-142

Department of Pathology, Beni Seuf University, Beni Seuf, Egypt.

The association of bilharziasis with membranous nephropathy (MN) has long been debated. The relatively recent use of antibodies against the M-type phospholipase A2 receptor (PLA2R) has been proposed as a valuable tool to discriminate the idiopathic from secondary MNs. Anti-PLA2R antibodies are found in sera from about 70% of iMN patients, in contrast to patients with secondary MN, in whom serum anti-PLA2R antibodies could not be detected. Read More

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http://dx.doi.org/10.4103/ijn.IJN_7_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440335PMC
April 2019
2 Reads

Supplementation with micronutrients and schistosomiasis: systematic review and meta-analysis.

Pathog Glob Health 2019 Apr 14:1-8. Epub 2019 Apr 14.

a Área de Medicina Preventiva y Salud Pública, Departamento de Medicina Preventiva y Salud Pública, Ciencias de la Alimentación, Toxicología y Medicina Legal, Facultad de Farmacia , Universitat de Valencia , Burjasot, Valencia , Spain.

Schistosomiasis is a parasitic disease caused by helminths of the genus Schistosoma with two presentations; one intestinal and another urinary; which depend on the specie of Schistosoma. One of the species that can produce intestinal schistosomiasis is Schistosoma mansoni, and the specie that produces urinary schistosomiasis is Schistosoma haematobium. Infection can be aggravated by a deficient nutritional status, which negatively impacts the immune system and increases susceptibility to infection. Read More

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http://dx.doi.org/10.1080/20477724.2019.1603902DOI Listing
April 2019
2 Reads

Environmental DNA for improved detection and environmental surveillance of schistosomiasis.

Proc Natl Acad Sci U S A 2019 Apr 11. Epub 2019 Apr 11.

Department of Veterinary and Animal Sciences, University of Copenhagen, DK-1870 Frederiksberg, Denmark.

Schistosomiasis is a water-based, infectious disease with high morbidity and significant economic burdens affecting >250 million people globally. Disease control has, with notable success, for decades focused on drug treatment of infected human populations, but a recent paradigm shift now entails moving from control to elimination. To achieve this ambitious goal, more sensitive diagnostic tools are needed to monitor progress toward transmission interruption in the environment, especially in low-intensity infection areas. Read More

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http://dx.doi.org/10.1073/pnas.1815046116DOI Listing
April 2019
3 Reads

Schistosoma haematobium infection status and its associated risk factors among pregnant women in Munyenge, South West Region, Cameroon following scale-up of communal piped water sources from 2014 to 2017: a cross-sectional study.

BMC Public Health 2019 Apr 11;19(1):392. Epub 2019 Apr 11.

Department of Medical Laboratory Science, Faculty of Health Sciences, University of Bamenda, P.O. Box 39, Bambili, Cameroon.

Background: In 2014, a study in Munyenge revealed a high prevalence of urogenital schistosomiasis (UGS) among pregnant women. This study investigated he prevalence and risk factors of UGS in pregnancy following scale-up of piped water sources from 2014 to 2017. Secondly, we compared stream usage, stream contact behaviour, infection rate and intensity with the findings of 2014. Read More

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http://dx.doi.org/10.1186/s12889-019-6659-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458650PMC

Nanoemulsion containing essential oil from Xylopia ochrantha Mart. produces molluscicidal effects against different species of Biomphalaria (Schistosoma hosts).

Mem Inst Oswaldo Cruz 2019 Apr 8;114:e180489. Epub 2019 Apr 8.

Universidade Federal Fluminense, Laboratório de Tecnologia de Produtos Naturais, Niterói, RJ, Brasil.

Background: This work describes a chemical study of the essential oil from leaves of Xylopia ochrantha, an endemic Annonaceae species from Brazil, and its activity against Biomphalaria species. Considering its poor solubility in aqueous medium, the essential oil was nanoemulsified to evaluate its action on controlling some mollusc species of genus Biomphalaria, snail hosts of Schistosoma mansoni that causes schistosomiasis, which mainly affects tropical and subtropical countries.

Objectives: The main aims of this work were to analyse the chemical composition of essential oil from X. Read More

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http://dx.doi.org/10.1590/0074-02760180489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454853PMC
April 2019
1 Read

Efficacy of China-made praziquantel for treatment of Schistosomiasis haematobium in Africa: A randomized controlled trial.

PLoS Negl Trop Dis 2019 Apr 10;13(4):e0007238. Epub 2019 Apr 10.

Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China.

Background: In the roadmap on the neglected tropical diseases (NTD) the World Health Organization (WHO) aims at attaining at least 75% coverage of preventive chemotherapy in pre-school and school-age children by 2020. A randomized controlled trial was used to compare the effectiveness of praziquantel in treating Schistosoma haematobium in Africa using two different sources for the drug, Merck Limited Partnership (KgaA), Germany and Nanjing Pharmaceutical Factory (NPF), China.

Methods: More than 6,000 participants testing positive for S. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007238
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http://dx.doi.org/10.1371/journal.pntd.0007238DOI Listing
April 2019
2 Reads

Acute appendicitis associated with the presence of schistosome eggs in a sailor: a case report.

Surg Case Rep 2019 Apr 8;5(1):55. Epub 2019 Apr 8.

Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki city, Nagasaki, 852-8501, Japan.

Background: Schistosomiasis is prevalent in tropical and subtropical areas and rarely reported in developed countries. Schistosomiasis often occurs as a chronic illness, which can cause liver and intestinal damage. Appendicitis is an unusual complication of schistosomiasis. Read More

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http://dx.doi.org/10.1186/s40792-019-0615-8DOI Listing
April 2019
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Megacolon due to Chronic Schistosomiasis: A Case Report and Review of Literature.

Case Rep Surg 2019 6;2019:4036823. Epub 2019 Mar 6.

Intensive Care Department, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.

Although Schistosoma infection in humans commonly involves the intestines, megacolon is a rare finding. We report a 47-year-old patient who was found to have chronic megacolon. After failing conservative management, he underwent extended hemicolectomy with colorectal anastomosis. Read More

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http://dx.doi.org/10.1155/2019/4036823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431392PMC
March 2019
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Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment.

J R Soc Interface 2019 Jan;16(150):20180675

1 Department of Mechanical and Aerospace Engineering, University of California San Diego , San Diego, CA , USA.

Schistosomiasis is a chronic and morbid disease of poverty affecting approximately 200 million people worldwide. Mature schistosome flatworms wander in the host's hepatic portal and mesenteric venous system where they encounter a range of blood flow conditions and geometrical confinement. However, the mechanisms that support schistosome locomotion and underlie the pathogen's adaptation to its physical environment are largely unknown. Read More

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http://dx.doi.org/10.1098/rsif.2018.0675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364656PMC
January 2019

Schistosoma mansoni infection among preschool age children attending Erer Health Center, Ethiopia and the response rate to praziquantel.

BMC Res Notes 2019 Apr 5;12(1):211. Epub 2019 Apr 5.

Department of Microbiology Immunology and Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Objective: Preschool age children (PSAC) are excluded from community based praziquantel treatment programs mainly due to paucity of evidence on the magnitude of schistosomiasis, efficacy and safety of this treatment in PSAC. The aim of this study is to assess Schistosoma mansoni infection rate and evaluate response to praziquantel in PSAC. A facility based longitudinal study was employed from April to June 2016 at Erer Health Center, Eastern Ethiopia. Read More

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http://dx.doi.org/10.1186/s13104-019-4246-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451229PMC
April 2019
1 Read

Mapping of Urinary Schistosomiasis in Anambra State, Nigeria.

Ann Glob Health 2019 Apr 2;85(1). Epub 2019 Apr 2.

Parasitology and Public Health Unit, Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, NG.

Background: Mapping the distribution of parasitic diseases in time and space has a pivotal role to play in their control.

Objective: This study mapped urinary schistosomiasis in Anambra State.

Methods: Sampling covered the three senatorial districts, Anambra North, Anambra Central and Anambra South. Read More

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http://dx.doi.org/10.5334/aogh.2393DOI Listing
April 2019
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Comprehensive analysis of miRNA profiles reveals the role of Schistosoma japonicum miRNAs at different developmental stages.

Vet Res 2019 Apr 4;50(1):23. Epub 2019 Apr 4.

State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200438, China.

Schistosomiasis is an important zoonotic disease affecting up to 40 kinds of animals and 250 million people. It has been reported that the miRNAs play a role in the metabolism, differentiation, development and reproduction in many organisms. However, the roles of miRNAs regulating the development, maturation and production in schistosome in both females and males remains unclear. Read More

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http://dx.doi.org/10.1186/s13567-019-0642-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449929PMC
April 2019
4 Reads

Female genital schistosomiasis and HIV/AIDS: Reversing the neglect of girls and women.

PLoS Negl Trop Dis 2019 Apr 4;13(4):e0007025. Epub 2019 Apr 4.

Regional Advisory Unit for Imported and Tropical Diseases, Department of Infectious Diseases, Ullevaal, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1371/journal.pntd.0007025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448816PMC

Treatment of presumed trematode-induced granulomatous anterior uveitis among children in rural areas of Egypt.

Eye (Lond) 2019 Apr 3. Epub 2019 Apr 3.

Mansoura Ophthalmic center, Mansoura University, Mansoura, Egypt.

Purpose: The purpose of this study is to evaluate the efficacy of systemic antiparasitic medications alone or in combination with surgical aspiration in management of presumed trematode-induced anterior uveitis in children.

Patients And Methods: Prospective case series. Children who presented with anterior chamber (AC) granuloma were included in the study. Read More

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http://dx.doi.org/10.1038/s41433-019-0428-9DOI Listing
April 2019
5 Reads

Urinary schistosomiasis in Nigeria: a 50 year review of prevalence, distribution and disease burden.

Parasite 2019 3;26:19. Epub 2019 Apr 3.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, PR China - College of Life Science, Fudan University, Shanghai, PR China.

We reviewed survey data deposited in the Global Neglected Tropical Diseases database and many other articles on the prevalence and distribution of Schistosoma haematobium in Nigeria. Schistosoma haematobium surveys conducted over the period of 50 years under review using different diagnostic tools revealed that Ogun State has the highest prevalence, followed by Ekiti state, while the lowest prevalence was recorded in Adamawa. No incidence of Schistosoma haematobium was recorded for states such as Akwa Ibom, Bayelsa, Nasarawa, Jigawa and Gombe. Read More

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http://dx.doi.org/10.1051/parasite/2019020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447092PMC
April 2019
1 Read

IgE antibodies from schistosomiasis patients to recognize epitopes in potato apyrase.

Rev Soc Bras Med Trop 2019 Mar 28;52:e20180139. Epub 2019 Mar 28.

Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.

Introduction: High percentages of structural identity and cross-immunoreactivity have been reported between potato apyrase and Schistosoma mansoni ATP diphosphohydrolase (SmATPDases) isoforms, showing the existence of particular epitopes shared between these proteins.

Methods: Potato apyrase was employed using ELISA, western blot, and mouse immunization methods to verify IgE reactivity.

Results: Most of the schistosomiasis patient's (75%) serum was seropositive for potato apyrase and this protein was recognized using western blotting, suggesting that parasite and plant proteins share IgE-binding epitopes. Read More

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http://dx.doi.org/10.1590/0037-8682-0139-2018DOI Listing
March 2019
3 Reads

Non-invasive surveillance of Plasmodium infection by real-time PCR analysis of ethanol preserved faeces from Ugandan school children with intestinal schistosomiasis.

Malar J 2019 Apr 1;18(1):109. Epub 2019 Apr 1.

Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.

Background: As part of ongoing co-surveillance of intestinal schistosomiasis and malaria in Ugandan school children, a non-invasive detection method for amplification of Plasmodium DNA using real-time (rt)PCR analysis of ethanol preserved faeces (EPF) was assessed. For diagnostic tabulations, results were compared to rtPCR analysis of dried blood spots (DBS) and field-based point-of-care (POC) rapid diagnostic tests (RDTs).

Methods: A total of 247 school children from 5 primary schools along the shoreline of Lake Albert were examined with matched EPF and DBS obtained. Read More

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http://dx.doi.org/10.1186/s12936-019-2748-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444585PMC
April 2019
1 Read
3.109 Impact Factor

The impact of climate variability on infectious disease transmission in China: Current knowledge and further directions.

Environ Res 2019 Mar 20;173:255-261. Epub 2019 Mar 20.

Division of Environmental Health, School of Public Health and Management, Weifang Medical University, Weifang, 261053, Shandong Province, PR China; "Health Shandong" Major Social Risk Prediction and Governance Collaborative Innovation Center, Weifang, 261053, Shandong Province, PR China. Electronic address:

Background: Climate change may lead to emerging and re-emerging infectious diseases and pose public health challenges to human health and the already overloaded healthcare system. It is therefore important to review current knowledge and identify further directions in China, the largest developing country in the world.

Methods: A comprehensive literature review was conducted to examine the relationship between climate variability and infectious disease transmission in China in the new millennium. Read More

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http://dx.doi.org/10.1016/j.envres.2019.03.043DOI Listing
March 2019
4 Reads

An immunohistochemical analysis of peptidergic neurons apparently associated with reproduction and growth in Biomphalaria alexandrina.

Gen Comp Endocrinol 2019 Mar 26. Epub 2019 Mar 26.

Department of Physiology & Biophysics, Dalhousie University, Halifax, NS, Canada. Electronic address:

Peptide hormones and neurotransmitters involved in reproduction and growth have been studied extensively in certain gastropod molluscs, such as Lymnaea stagnalis and Aplysia californica. The present study employs antisera that have been used to study peptidergic neurons in those species to probe the central nervous system of another gastropod, Biomphalaria alexandrina, an intermediate host of the parasitic trematode that causes schistosomiasis in humans. Whole mount preparations of central ganglia were stained immunohistochemically, and several populations of neurons appeared to be homologous to those forming the neuroendocrine axis that has been previously described in L. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.03.017DOI Listing
March 2019
1 Read

Distribution pattern of the snail intermediate host of schistosomiasis japonica in the Poyang Lake region of China.

Infect Dis Poverty 2019 Mar 29;8(1):23. Epub 2019 Mar 29.

Jiangxi Provincial Institute of Parasitic Diseases, No. 239, First Gaoxin Rd., Gaoxin District, 330096, Nanchang, Jiangxi Province, People's Republic of China.

Background: With the closure of the Three Gorges Dam in 2003 the hydrology of Poyang Lake was altered dramatically leading to significant changes in the environment. In order to assess the impact on schistosomiasis this study assessed the spatial and temporal patterns of the snail intermediate host, Oncomelania hupensis in the Poyang Lake tributaries. The results of the study have important implications for future snail control strategies leading to disease elimination. Read More

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http://dx.doi.org/10.1186/s40249-019-0534-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440081PMC
March 2019
2 Reads

Correction to: Urogenital schistosomiasis elimination in Zanzibar: accuracy of urine filtration and haematuria reagent strips for diagnosing light intensity Schistosoma haematobium infections.

Parasit Vectors 2019 03 28;12(1):149. Epub 2019 Mar 28.

Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, Natural History Museum, Cromwell Road, London, SW7 5BD, UK.

Following publication of the original article [1], the authors flagged that unfortunately an error had been introduced to the Conclusions section of the article's Abstract, during production of the article. Read More

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http://dx.doi.org/10.1186/s13071-019-3397-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440130PMC
March 2019
3.430 Impact Factor

Recruitment of hepatic macrophages from monocytes is independent of IL-4Rα but is associated with ablation of resident macrophages in schistosomiasis.

Eur J Immunol 2019 Mar 28. Epub 2019 Mar 28.

Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Liège, Belgium.

Alternatively-activated Mφs (AAMφ) accumulate in hepatic granulomas during schistosomiasis and have been suggested to originate in the bone marrow. What is less understood is how these Mφ responses are regulated after S. mansoni infection. Read More

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http://dx.doi.org/10.1002/eji.201847796DOI Listing
March 2019
1 Read

Profiling the best-performing community medicine distributors for mass drug administration: a comprehensive, data-driven analysis of treatment for schistosomiasis, lymphatic filariasis, and soil-transmitted helminths in Uganda.

BMC Med 2019 Mar 28;17(1):69. Epub 2019 Mar 28.

Vector Control Division, Bilharzia and Worm Control Programme, Uganda Ministry of Health, Kampala, Uganda.

Background: The most prevalent neglected tropical diseases are treated through blanket drug distribution that is reliant on lay community medicine distributors (CMDs). Yet, treatment rates achieved by CMDs vary widely and it is not known which CMDs treat the most people.

Methods: In Mayuge District, Uganda, we tracked 6779 individuals (aged 1+ years) in 1238 households across 31 villages. Read More

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http://dx.doi.org/10.1186/s12916-019-1303-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437990PMC
March 2019
1 Read

Child development center-based sentinel surveillance of soil-transmitted helminthiases in preschool-age children in selected local government units in the Philippines.

Acta Trop 2019 Mar 23;194:100-105. Epub 2019 Mar 23.

Department of Health Regional Office XI, Davao City, Philippines.

Soil-transmitted helminthiasis (STH) remains a public health concern in developing countries, such as the Philippines. Preschool-age children (PSAC) are among the high-risk groups for STH. Data on the status of STH in PSAC are needed to help guide policy formulation and program implementation; however, in the usual setting, such data may remain limited. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.03.023DOI Listing
March 2019
1 Read

High prevalence of Pfdhfr-Pfdhps quadruple mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea.

Malar J 2019 Mar 26;18(1):101. Epub 2019 Mar 26.

Department of Human Parasitology, School of Basic Medical Sciences, Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China.

Background: Sulfadoxine-pyrimethamine (SP) is recommended for intermittent preventive treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the therapeutic efficacy of the SP. As molecular markers, Pfdhfr (dihydrofolate reductase) and Pfdhps (dihydropteroate synthase) genes are widely used for SPR surveillance. Read More

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http://dx.doi.org/10.1186/s12936-019-2734-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434785PMC

Detection of Schistosoma mansoni-derived DNA in human urine samples by loop-mediated isothermal amplification (LAMP).

PLoS One 2019 26;14(3):e0214125. Epub 2019 Mar 26.

Infectious and Tropical Diseases Research Group (e-INTRO), Biomedical Research Institute of Salamanca-Research Centre for Tropical Diseases at the University of Salamanca (IBSAL-CIETUS), Faculty of Pharmacy, University of Salamanca, Salamanca, Spain.

Background: Schistosoma mansoni is the main species causing hepatic and intestinal schistosomiasis in Sub-Saharan Africa, and it is the only species in South America. Adult stages of the parasite reside in the mesenteric venous plexus of infected hosts, and eggs are shed in feces. Collecting patient stool samples for S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214125PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435178PMC

Effect of omega-3 fatty acids administered as monotherapy or combined with artemether on experimental Schistosoma mansoni infection.

Acta Trop 2019 Mar 22;194:62-68. Epub 2019 Mar 22.

Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.

Schistosomiasis is on the top list of endemic diseases in sub-Saharan Africa. Praziquantel is the drug of choice for treatment of human schistosomiasis. Yet, the sole dependence on the drug raises concerns about the potential for increased drug resistance, which would subsequently result in searching for alternative preventive chemotherapy options, ideally among natural compounds. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.027DOI Listing
March 2019
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2.270 Impact Factor

Expression and prognostic utility of PD-L1 in patients with squamous cell carcinoma of the bladder.

Urol Oncol 2019 Mar 22. Epub 2019 Mar 22.

Department of Urology, University of California Irvine, Orange, CA. Electronic address:

Objectives: Checkpoint inhibitors are approved for the treatment of urothelial bladder cancer. However, there have been no reports on the prognostic value of programmed-death receptor ligand 1 (PD-L1) expression in squamous cell carcinoma (SCC) of the bladder. We assessed the relationship between PD-L1 expression, clinicopathological features, and oncologic outcomes in bladder SCC. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.02.017DOI Listing
March 2019
2 Reads

Assessment of health education products aimed at controlling and preventing helminthiases in China.

Infect Dis Poverty 2019 Mar 26;8(1):22. Epub 2019 Mar 26.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.

Background: Helminthiases have placed a huge burden of disease on the population in China. However, widespread control activities have led to significant achievements. As health education has been widely disseminated and plays an important role in the control and elimination of these diseases, we collected health education products aimed at controlling and preventing helminthiases in China. Read More

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http://dx.doi.org/10.1186/s40249-019-0531-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434872PMC
March 2019
2 Reads

Correction to: In vitro schistosomicidal activity of tamoxifen and its effectiveness in a murine model of schistosomiasis at a single dose.

Parasitol Res 2019 Mar 22. Epub 2019 Mar 22.

Biology Institute, Department of Animal Biology - Parasitology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.

The original published version of this article contains error in Tables 1 and 2. Correct tables are presented here. Read More

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http://dx.doi.org/10.1007/s00436-019-06290-1DOI Listing

A major hurdle in the elimination of urogenital schistosomiasis revealed: Identifying key gaps in knowledge and understanding of female genital schistosomiasis within communities and local health workers.

PLoS Negl Trop Dis 2019 03 21;13(3):e0007207. Epub 2019 Mar 21.

COUNTDOWN Consortium, Institute for Health Research, University of Health and Allied Sciences, Ho, Ghana.

Background: Urogenital schistosomiasis is endemic throughout Ghana with elevated infection levels in certain areas e.g. Lake Volta Region. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428244PMC
March 2019
2 Reads

Sympatric versus allopatric evolutionary contexts shape differential immune response in Biomphalaria / Schistosoma interaction.

PLoS Pathog 2019 03 20;15(3):e1007647. Epub 2019 Mar 20.

Univ. Perpignan Via Domitia, Interactions Hôtes Pathogènes Environnements UMR 5244, CNRS, IFREMER, Univ. Montpellier, Perpignan, France.

Selective pressures between hosts and their parasites can result in reciprocal evolution or adaptation of specific life history traits. Local adaptation of resident hosts and parasites should lead to increase parasite infectivity/virulence (higher compatibility) when infecting hosts from the same location (in sympatry) than from a foreign location (in allopatry). Analysis of geographic variations in compatibility phenotypes is the most common proxy used to infer local adaptation. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443186PMC

[Endemic situation of schistosomiasis in surveillance sites of Jingzhou City, 2017].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Jul;30(6):691-693

College of Traditional Chinese Medicine in Hubei, China.

Objective: To grasp the endemic situation of schistosomiasis in Jingzhou City in 2017, so as to provide the evidence for formulating prevention strategies.

Methods: According to the requirements of (), () and , the local population infection monitoring, mobile population infection monitoring, livestock disease monitoring, snail monitoring, and wild manure monitoring were carried out at 71 monitoring sites throughout the city.

Results: Among the 71 surveillance sites, 44 118 local residents received the indirect hemagglutination test (IHA) for schistosomiasis and 1 925 persons were positive, with the positive rate of 4. Read More

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http://www.cnki.net/kcms/doi/10.16250/j.32.1374.2018184.html
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http://dx.doi.org/10.16250/j.32.1374.2018184DOI Listing
July 2018
8 Reads

[Role of WeChat publicity in control of imported malaria from abroad in timber industry].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Aug;30(6):688-690

Jiangsu Provincial Center for Disease Control and Prevention, China.

Objective: To evaluate the effects of WeChat publicity in imported malaria control in timber industry in Zhangjiagang City, so as to provide new ideas for the control of malaria imported from abroad.

Methods: The data of malaria epidemic in Zhangjiagang City was collected, and the contact way of the overseas personnel in timber industry in Zhangjiagang City were obtained. The knowledge of the prevention and control of malaria was propagandized by WeChat among these personnel, and the awareness situation of malaria control knowledge of this population was investigated by questionnaires before and after the WeChat publicity. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018202DOI Listing
August 2018
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[Major challenges of schistosomiasis elimination in Hubei Province].

Authors:
Hong Zhi-Hua

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Aug;30(6):685-687

Office of Leading Group for Schistosomiasis Control in Hubei Province, Wuhan 430079, China.

This paper summarizes the major experiences from schistosomiasis control, analyzes the challenges of schistosomiasis elimination, and proposes suggestions for further control programs in Hubei Province, with aims to provide insights into the acceleration of the progress towards schistosomiasis elimination and the achievement of the goal designed in the in China. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018206DOI Listing

[Effect and cost-effectiveness of three commonly used molluscicides in largescale field application].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Sep;30(6):619-624

Yangzhou Center for Disease Control and Prevention, Jiangsu Province, China.

Objective: To evaluate the effect and cost-effectiveness of three commonly used molluscicides, 4% "Luo-wei" (tea-seed distilled saponins, TDS), 50% niclosamide ethanolamine salt wettable powder (NESWP), and 26% metaldehyde and niclosamide suspension concentrate (MNSC) in large-scale field application, so as to provide the references for formulating the strategy of snail control.

Methods: The field test and parallel comparison were implemented. A marshland with snails of the Yangtze River was divided into 4 parts (10 hm) for the research, and three of them were experimental areas while the last one was a blank control area. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018222DOI Listing
September 2018
2 Reads

[Evaluation of implementation effect of schistosomiasis control program in Jiangsu Province from 2010 to 2015].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Jan;30(6):615-618

Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Public Health Research Center at Jiangnan University, Wuxi 214064, China.

Objective: To evaluate the actual effect of the schistosomiasis control program in Jiangsu Province from 2010 to 2015.

Methods: A total of 67 schistosomiasis-endemic counties in 10 cities were selected, and a combination of retrospective investigation and on-site investigation was adopted to collect and record the epidemic data of the counties from 2010 to 2015, and a retrospective survey database of epidemic situation was established. The effects of integrated control strategies with both snail control and infection source control were evaluated. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018209DOI Listing
January 2019
4 Reads

[Challenges and countermeasures of schistosomiasis elimination in Jiangxi Province].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Jul;30(6):610-614

Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330096, China.

Jiangxi Province was once one of schistosomiasis heavy endemic provinces in China. Thanks for more than 60 years' unremitting effort, great achievements have been obtained in schistosomiasis control in this province. This paper reviews the control history of schistosomiasis, and demonstrates the current epidemic situation of the disease in Jiangxi Province, and its contribution to national schistosomiasis control achievements. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018183DOI Listing
July 2018
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[Progress and challenges of schistosomiasis elimination in China].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Oct;30(6):605-609

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; WHO Collaborating Center for Tropical Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China.

Schistosomiasis is an old and geographically widespread parasitic disease that severely damages human health and affects socioeconomic development in China. The implementation of the integrated strategy with emphasis on controlling the source of infection and the (20042015) greatly facilitated the progress towards the elimination of schistosomiasis in China. Since transmission control of schistosomiasis was achieved in 2015, the goal of the national schistosomiasis control program has moved to transmission interruption and elimination in China. Read More

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http://www.cnki.net/kcms/doi/10.16250/j.32.1374.2018249.html
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http://dx.doi.org/10.16250/j.32.1374.2018249DOI Listing
October 2018
6 Reads

[Interpretation of () : schistosomiasis].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Dec;30(6):601-604

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health Commission, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China.

(20182020), which was formulated by 10 ministries of China, was issued on November 29, 2018. Schistosomiasis control is an important part of this plan, and the implementation of the plan provides an important basis for the health poverty alleviation and the fight against schistosomiasis in China. This paper describes the objective and principle of the plan and proposes "six actions" and supporting measures to implement the three-year tough action targeting schistosomiasis, with aims to guide the scientific implementation of the three-year tough action against schistosomiasis and facilitate the progress towards schistosomiasis elimination in China. Read More

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http://www.cnki.net/kcms/doi/10.16250/j.32.1374.2018311.html
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http://dx.doi.org/10.16250/j.32.1374.2018311DOI Listing
December 2018
6 Reads