26,185 results match your criteria Schistosomiasis


Host Regulators of Liver Fibrosis During Human Schistosomiasis.

Front Immunol 2018 28;9:2781. Epub 2018 Nov 28.

Cape Town Component, International Centre for Genetic Engineering and Biotechnology, Cape Town, South Africa.

Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical stress or infections. The uncontrolled solicitation of this process is pathogenic and a pathognomonic feature of diseases like hepatosplenic schistosomiasis where exacerbated liver fibrosis is centrally positioned among the drivers of the disease morbidity and mortality. Intriguingly, however, liver fibrosis occurs and progresses dissimilarly in schistosomiasis-diseased individuals with the same egg burden and biosocial features including age, duration of residence in the endemic site and gender. Read More

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November 2018
1 Read

Schistosomiasis is associated with incident HIV transmission and death in Zambia.

PLoS Negl Trop Dis 2018 Dec 13;12(12):e0006902. Epub 2018 Dec 13.

Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America.

Background: We examined relationships between schistosome infection, HIV transmission or acquisition, and all-cause death.

Methods: We retrospectively tested baseline sera from a heterosexual HIV-discordant couple cohort in Lusaka, Zambia with follow-up from 1994-2012 in a nested case-control design. Schistosome-specific antibody levels were measured by ELISA. Read More

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December 2018

Unresolved Splenomegaly in Recently Resettled Congolese Refugees - Multiple States, 2015-2018.

MMWR Morb Mortal Wkly Rep 2018 12 14;67(49):1358-1362. Epub 2018 Dec 14.

In 2014, panel physicians from the International Organization for Migration (IOM), who conduct Department of State-required predeparture examinations for U.S.-bound refugees at resettlement sites in Uganda, noticed an unusually high number of Congolese refugees with enlarged spleens, or splenomegaly. Read More

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December 2018

Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases.

Mucosal Immunol 2018 Dec 12. Epub 2018 Dec 12.

International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, 7925, South Africa.

Basic leucine zipper transcription factor 2 (Batf2) activation is detrimental in Type 1-controlled infectious diseases, demonstrated during infection with Mycobacterium tuberculosis (Mtb) and Listeria monocytogenes Lm. In Batf2-deficient mice (Batf2), infected with Mtb or Lm, mice survived and displayed reduced tissue pathology compared to infected control mice. Indeed, pulmonary inflammatory macrophage recruitment, pro-inflammatory cytokines and immune effectors were also decreased during tuberculosis. Read More

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December 2018

Integrating ecological approaches to interrupt schistosomiasis transmission: opportunities and challenges.

Infect Dis Poverty 2018 Dec 12;7(1):124. Epub 2018 Dec 12.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.

Background: The development of agenda for global schistosomiasis elimination as a public health problem generates enthusiasms among global health communities, motivating great interests in both research and practice. Recent China-Africa schistosomiasis control initiatives, aiming to enhance collaboration on disease control in African countries, reflect in part that momentum. Yet there is a pressing need to know whether the Chinese experiences can be translated and applied in African settings. Read More

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December 2018

Data and tools to integrate climate and environmental information into public health.

Infect Dis Poverty 2018 Nov 29;7(1):126. Epub 2018 Nov 29.

The International Research Institute for Climate and Society, The Earth Institute, Columbia University, 61 Route 9W, Lamont-Doherty, Palisades, NY, 10964, USA.

Background: During the last 30 years, the development of geographical information systems and satellites for Earth observation has made important progress in the monitoring of the weather, climate, environmental and anthropogenic factors that influence the reduction or the reemergence of vector-borne diseases. Analyses resulting from the combination of geographical information systems (GIS) and remote sensing have improved knowledge of climatic, environmental, and biodiversity factors influencing vector-borne diseases (VBDs) such as malaria, visceral leishmaniasis, dengue, Rift Valley fever, schistosomiasis, Chagas disease and leptospirosis. These knowledge and products developed using remotely sensed data helped and continue to help decision makers to better allocate limited resources in the fight against VBDs. Read More

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November 2018

Relative bioavailability of orally dispersible/disintegrating tablet formulations of levo- and racemic praziquantel: Two Phase I studies.

Clin Transl Sci 2018 Dec 7. Epub 2018 Dec 7.

Quantitative Pharmacology, Merck KGaA, Frankfurter Strasse 250, 64293, Darmstadt, Germany.

Orally dispersible tablet (ODT) formulations of L- and racemic praziquantel (PZQ) are being developed to treat schistosomiasis in preschool-aged children. Two cross-over studies (N=32 and 36 resp.) assessed the relative bioavailability of these ODTs versus Cysticide in adults. Read More

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December 2018
2 Reads

Coinfections between Persistent Parasitic Neglected Tropical Diseases and Viral Infections among Prisoners from Sub-Saharan Africa and Latin America.

J Trop Med 2018 6;2018:7218534. Epub 2018 Nov 6.

Division of Prison Health, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

In Swiss prisons, more than 70% of detained people are foreigners and over one-third originate from sub-Saharan Africa or Latin America. These two regions are endemic for various tropical diseases and viral infections, which persist after migration to nonendemic countries. Parasitic infections (schistosomiasis; strongyloidiasis) and cooccurrent viral infections (HIV, hepatitis B (HBV), and hepatitis C (HCV)) are especially of concern for clinical care but have been neglected in empirical research. Read More

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November 2018
1 Read

Safety and efficacy of the rSh28GST urinary schistosomiasis vaccine: a phase 3 randomized, controlled trial in Senegalese children.

PLoS Negl Trop Dis 2018 Dec 7;12(12):e0006968. Epub 2018 Dec 7.

Académie des Sciences, 23 Quai de Conti, Paris, France.

Background: Urinary schistosomiasis, the result of infection by Schistosoma haematobium (Sh), remains a major global health concern. A schistosome vaccine could represent a breakthrough in schistosomiasis control strategies, which are presently based on treatment with praziquantel (PZQ). We report the safety and efficacy of the vaccine candidate recombinant 28-kDa glutathione S-transferase of Sh (rSh28GST) designated as Bilhvax, in a phase 3 trial conducted in Senegal. Read More

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December 2018

[Schistosomiasis japonica in a patient who emigrated from China: a case report].

Nihon Shokakibyo Gakkai Zasshi 2018 ;115(12):1094-1100

Department of Gastroenterology, Iwata City Hospital.

A 37-year-old woman exhibited abnormal liver enzyme levels without any symptoms at a medical check-up. She was born and raised in Hubei, China, and had immigrated to Japan in her mid-thirties. Ultrasonography revealed an enlarged caudate lobe of the liver and a wide moniliform portal vein, whereas computed tomography revealed lined calcification on the surface of the liver and on the collateral vein of the portal vein. Read More

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January 2018
1 Read

Molecular characterisation of immunological memory following homologous or heterologous challenges in the schistosomiasis vector snail, Biomphalaria glabrata.

Dev Comp Immunol 2018 Dec 4;92:238-252. Epub 2018 Dec 4.

Univ. Perpignan Via Domitia, Interactions Hôtes Pathogènes Environments UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860, Perpignan, France. Electronic address:

Invertebrate immune response may be primed by a current infection in a sustained manner, leading to the failure of a secondary infection with the same pathogen. The present study focuses on the Schistosomiasis vector snail Biomphalaria glabrata, in which a specific genotype-dependent immunological memory was demonstrated as a shift from a cellular to a humoral immune response. Herein, we investigate the complex molecular bases associated with this genotype-dependant immunological memory response. Read More

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December 2018

Design and validation of a wide-field mobile phone microscope for the diagnosis of schistosomiasis.

Travel Med Infect Dis 2018 Dec 4. Epub 2018 Dec 4.

Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA; California NanoSystems Institute, University of California, Los Angeles, CA, 90095, USA. Electronic address:

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December 2018

Schistosomiasis.

Authors:
Richard Barnett

Lancet 2018 Dec;392(10163):2431

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December 2018

Schistosoma haematobium-Schistosoma mansoni Hybrid Parasite in Migrant Boy, France, 2017.

Emerg Infect Dis 2019 Feb 17;25(2). Epub 2019 Feb 17.

Schistosomiasis is frequently detected in persons entering Europe. In 2017, we detected a Schistosoma mansoni-Schistosoma haematobium hybrid parasite infection in a migrant boy from Côte d'Ivoire entering France. Because such parasites might be established in Europe, as illustrated by an outbreak on Corsica Island, vectors of these parasites should be investigated. Read More

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February 2019

ABO blood group antigens may be associated with increased susceptibility to schistosomiasis: a systematic review and meta-analysis.

J Helminthol 2018 Dec 11:1-10. Epub 2018 Dec 11.

Department of Medical Technology,Faculty of Pharmacy,University of Santo Tomas,Manila,Philippines.

Schistosomiasis or bilharzia is a widespread parasitic disease caused by blood flukes of the genus Schistosoma. Some factors have been investigated previously regarding their effect on the pathophysiological mechanism of human schistosomiasis, but the possible influence of the ABO blood group on the severity of Schistosoma infection has been the most promising. Hence, we performed a systematic review and meta-analysis to further investigate the association of the ABO blood group with schistosomiasis susceptibility. Read More

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December 2018

Morphological and molecular characterization of invasive Biomphalaria straminea in southern China.

Infect Dis Poverty 2018 Dec 8;7(1):120. Epub 2018 Dec 8.

National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.

Background: Schistosomiasis is a common parasitic disease designated as a neglected tropical disease by the World Health Organization. Schistosomiasis mansoni is a form of the disease that is caused by the digenean trematode Schistosoma mansoni, transmitted through Biomphalaria spp. as an intermediate host. Read More

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December 2018

Co-parasitism of intestinal protozoa and Schistosoma japonicum in a rural community in the Philippines.

Infect Dis Poverty 2018 Dec 10;7(1):121. Epub 2018 Dec 10.

Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia.

Background: Co-parasitism is a frequent occurrence in impoverished communities in the tropics resulting in a considerable disease burden. While there are extensive reports of intestinal helminthiases, including schistosomiasis japonica, the occurrence and extent of diseases caused by intestinal protozoa (IP) have yet to be investigated in depth in the Philippines. We present a detailed analysis of polyparasitism in a rural community of Northern Samar, focusing on co-infections of IP with Schistosoma japonicum. Read More

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December 2018

Optimal control applied to a temperature dependent schistosomiasis model.

Biosystems 2018 Dec 3. Epub 2018 Dec 3.

School of Life Sciences, College of Agriculture, Engineering and Science, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.

Schistosomiasis, the most common water-borne infection worldwide, continues to pose a serious public health challenge in developing nations and to travellers who visit these endemic regions. We apply optimal control on a temperature dependent schistosomiasis model. Our optimal control aims to minimize the pre-patent and patent human population at minimal costs. Read More

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December 2018
3 Reads

Urinary schistosomiasis: report of case diagnosed in bladder biopsy.

BMC Clin Pathol 2018 28;18:13. Epub 2018 Nov 28.

Department of Pathology, Military General Hospital Mohammed V, Mohammed V- Souissi University, Hay Riad, 10000 Rabat, Morocco.

Background: Urinary schistosomiasis is a common parasitic disease in endemic countries.

Case Presentation: We report the case of a patient who was on a working trip to Mauritania. This parasitosis, suspected in the presence of hematuria and the notion of stay in an endemic zone, was confirmed by the presence of Schistosoma heamatobium eggs during the histological examination of the bladder biopsy performed after cystoscopy, highlighting a bilharzial granuloma and of course, the diagnosis was confirmed by the presence of eggs during the direct examination of the freshly collected urine. Read More

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November 2018
1 Read

Interaction and involvement of cellular adhesion molecules in the pathogenesis of Schistosomiasis mansoni.

Immunol Lett 2018 Nov 29;206:11-18. Epub 2018 Nov 29.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Parasites from genus Schistosoma currently infect more than 200 million people worldwide. Infection with Schistosoma mansoni causes intestinal schistosomiasis with geographical distribution across Africa, Middle East, Caribbean, Brazil, Venezuela and Suriname. People with Schistosomiasis mansoni suffer from a chronic disease as result of an exacerbated immune response to the eggs deposited in hepatic tissue. Read More

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November 2018
1 Read

TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling.

Int J Parasitol Drugs Drug Resist 2018 Dec 20;8(3):571-586. Epub 2018 Nov 20.

Center for Discovery and Innovation in Parasitic Diseases, University of California, 1700 4th St, San Francisco, CA, 94158, USA; Department of Pathology, University of California, 1700 4th St, San Francisco, CA, 94158, USA. Electronic address:

Treatment of schistosomiasis relies precariously on just one drug, praziquantel (PZQ). In the search for alternatives, 15 S-[2-(alkylamino)alkane] thiosulfuric acids were obtained from a previous research program and profiled in mice for efficacy against both mature (>42-day-old) and juvenile (21-day-old) Schistosoma mansoni using a screening dose of 100 mg/kg PO QDx4. One compound, S-[2-(tert-butylamino)-1-phenylethane] thiosulfuric acid (TPT sulfonate), was the most effective by decreasing female and male worm burdens by ≥ 90% and ≥46% (mature), and ≥89% and ≥79% (juvenile), respectively. Read More

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December 2018

Early complicated schistosomiasis in a returning traveler: key contribution of new molecular diagnostic methods.

Int J Infect Dis 2018 Nov 28. Epub 2018 Nov 28.

Division of clinical tropical medicine, Department for infectious and tropical diseases, Bordeaux University hospital, Bordeaux, France. Electronic address:

Early schistosomiasis poses serious diagnostic challenges, because current standard diagnostic techniques based on serology and egg microscopy lack sensitivity at the initial presentation. We report spinal cord neuroschistosomiasis in a traveler developing six weeks after exposure. Diagnosis was confirmed by Schistosoma mansoni-targeting real-time polymerase chain reaction in blood and CSF, before results of conventional methods became positive. Read More

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November 2018

The double burden of diabetes and global infection in low and middle-income countries.

Trans R Soc Trop Med Hyg 2018 Dec 4. Epub 2018 Dec 4.

Cardiometabolic Research Group, Department of Social Medicine, Sunpasitthiprasong Hospital, Tambon Nai Mueang, Amphoe Mueang Ubon Ratchathani, Chang Wat Ubon Ratchathani, Thailand.

Four out of five people in the world with diabetes now live in low- and middle-income countries (LMIC), and the incidence of diabetes is accelerating in poorer communities. Diabetes increases susceptibility to infection and worsens outcomes for some of the world's major infectious diseases such as tuberculosis, melioidosis and dengue, but the relationship between diabetes and many neglected tropical diseases is yet to be accurately characterised. There is some evidence that chronic viral infections such as hepatitis B and HIV may predispose to the development of type 2 diabetes by chronic inflammatory and immunometabolic mechanisms. Read More

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December 2018
4 Reads

Investigation of schistosomiasis cases and deaths in the city of Recife, Pernambuco, Brazil, 2005-2013.

Epidemiol Serv Saude 2018 Nov 29;27(4):e2017190. Epub 2018 Nov 29.

Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.

Objective: to describe schistosomiasis cases and deaths among residents of the city of Recife, Pernambuco, Brazil, from 2005 to 2013.

Methods: this was a descriptive epidemiological study using data from the Mortality Information System (SIM) (2005-2013) and the Notifiable Diseases Information System (SINAN) (2007-2013); active tracing of the relatives of the dead was undertaken and probabilistic linkage of the databases (2007-2013) was performed using the Reclink program.

Results: 297 schistosomiasis deaths were recorded on the SIM system; through active tracing, 130 relatives were contacted and 20. Read More

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November 2018
3 Reads

A survey of freshwater and terrestrial snails in a predominantly urban municipality of Rio de Janeiro State, Brazil, with emphasis on human parasites vectors.

Rev Inst Med Trop Sao Paulo 2018 Nov 29;60:e76. Epub 2018 Nov 29.

Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Rio de Janeiro, Rio de Janeiro, Brazil.

Many snail species act as intermediate hosts of helminths that transmit diseases to humans and animals, such as schistosomiasis and angiostrongyliasis. São Gonçalo, a mostly urban municipality in Rio de Janeiro State, Brazil, has undergone fundamental environmental impacts, which favor the establishment of a range of diseases, for which snails act as the intermediate hosts of the etiological agents. In the present study, freshwater and terrestrial snail populations were surveyed in different environments within five city districts, and the presence of helminths was determined in the collected specimens. Read More

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November 2018
1 Read

IL-4Rα-expressing CD11c cells contribute to driving optimal cellular responses during Schistosoma mansoni infection in mice.

J Leukoc Biol 2018 Nov 30. Epub 2018 Nov 30.

International Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.

Development of IL-4 receptor alpha (IL-4Rα)-dependent cellular immunity regulates host protection against acute schistosomiasis. In this study, we investigated the importance of IL-4Rα-expressing CD11c cells in driving the development of optimal cellular responses to Schistosoma mansoni infection by using CD11c IL-4Rα BALB/c mice, which lacked IL-4Rα expression on dendritic cells and alveolar macrophages. Abrogation of IL-4Rα expression on CD11c cells affected activation of CD4 T cells, resulting in reduced numbers of effector CD4 T cells and impaired production of Th1 and Th2 cytokines by CD4 T cells ex vivo. Read More

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November 2018

Effect of high-intensity versus low-intensity praziquantel treatment on HIV disease progression in HIV and co-infected patients: a randomised controlled trial.

Wellcome Open Res 2018 5;3:81. Epub 2018 Jul 5.

MRC UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda.

It has been hypothesised that co-infection exacerbates HIV progression, and hence anthelminthic intervention in co-infected individuals will delay it. We evaluated effects of high-intensity versus low-intensity praziquantel treatment of schistosomiasis on HIV disease progression among co-infected patients from fishing populations around Lake Victoria, Uganda. : Between August 2012 and September 2015, we conducted an open-label randomised, controlled trial. Read More

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[Prevalence of Malaria, Intestinal and Urinary parasite infections in Kalifabougou, Mali].

Mali Med 2018 ;33(1):10-15

Soil transmitted helminthiasis and schistosomiasis are neglected tropical diseases (NTD), affecting the health status of endemic Malian populations. Mali has a national NTD elimination program using the mass drug administration (MDA) strategy combining Albendazole, Ivermectinand Praziquantel. Malaria still remains a public health problem in Mali. Read More

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January 2018

Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype.

Front Immunol 2018 12;9:2580. Epub 2018 Nov 12.

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States.

Hepatic macrophages play an essential role in the granulomatous response to infection with the parasitic helminth , but the transcriptional changes that underlie this effect are poorly understood. To explore this, we sorted the two previously recognized hepatic macrophage populations (perivascular and Kupffer cells) from naïve and -infected male mice and performed microarray analysis as part of the Immunological Genome Project. The two hepatic macrophage populations exhibited remarkably different genomic profiles. Read More

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November 2018
1 Read

Circulating miRNAs as footprints for liver fibrosis grading in schistosomiasis.

EBioMedicine 2018 Nov 25;37:334-343. Epub 2018 Oct 25.

Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia. Electronic address:

Background: Chronic infection with Schistosoma japonicum or S. mansoni results in hepatic fibrosis of the human host. Staging fibrosis is crucial for the prognosis and to determine the rapid need of treatment in patients with schistosomiasis. Read More

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November 2018

Interactive online application for the prediction, ranking and prioritisation of drug targets in Schistosoma haematobium.

Parasit Vectors 2018 Nov 27;11(1):605. Epub 2018 Nov 27.

Melbourne Veterinary School, Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.

Background: Human schistosomiasis is a neglected tropical disease caused by parasitic worms of the genus Schistosoma that still affects some 200 million people. The mainstay of schistosomiasis control is a single drug, praziquantel. The reliance on this drug carries a risk of resistance emerging to this anthelmintic, such that research towards alternative anti-schistosomal drugs is warranted. Read More

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November 2018
1 Read

Schistosomiasis in a Scottish school group after freshwater swimming in Uganda: the need to raise awareness.

JMM Case Rep 2018 Oct 25;5(10):e005166. Epub 2018 Sep 25.

Scottish Parasite Diagnostic and Reference Laboratory (SPDRL), NHS Greater Glasgow and Clyde, UK.

Introduction: Schistosomiasis, a travel-related trematode infection, can cause a range of symptoms with potentially life-threatening complications. In this report, we describe an outbreak of schistosomiasis in a Scottish school group that had travelled to Uganda. We discuss the requirement for robust and accurate pre-travel advice, and the importance of raising awareness in travellers, particularly due to the asymptomatic nature of the disease. Read More

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October 2018
1 Read

Are Medical Laboratories Ready for the Diagnosis of Parasitic Diseases?

Authors:
Ahmet Özbilgin

EJIFCC 2018 Nov 7;29(3):171-174. Epub 2018 Nov 7.

Department of Parasitology, Faculty of Medicine, University of Manisa Celal Bayar, Manisa, Turkey.

Economic instability, destabilisation with armed conflagration, religious and ethnic conflicts are the most important driving factors for migrations towards Europe. Mediterranean countries are important route for refugees who emigrate from the Middle East, Africa and Asia. Viral, bacterial, parasitic and fungal diseases carried by these refugees constitute a significant health risk in Mediterranean countries. Read More

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November 2018
4 Reads

Potential Biological Control of Schistosomiasis by Fishes in the Lower Senegal River Basin.

Am J Trop Med Hyg 2018 Nov 26. Epub 2018 Nov 26.

Hopkins Marine Station of Stanford University, Pacific Grove, California.

More than 200 million people in sub-Saharan Africa are infected with schistosome parasites. Transmission of schistosomiasis occurs when people come into contact with larval schistosomes emitted from freshwater snails in the aquatic environment. Thus, controlling snails through augmenting or restoring their natural enemies, such as native predators and competitors, could offer sustainable control for this human disease. Read More

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November 2018
2 Reads

[Etiological diagnosis of pulmonary hypertension: A cause of difficult diagnosis].

Rev Mal Respir 2018 Nov 22. Epub 2018 Nov 22.

Service de pneumologie de Louis-Pradel, centre national de référence des maladies pulmonaires rares, centre de compétence de l'hypertension pulmonaire, groupement hospitalier Est, hospices civils de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France; Université Claude-Bernard Lyon 1, 8, avenue Rockefeller, 69008, Lyon, France. Electronic address:

Introduction: Schistosomiasis associated pulmonary arterial hypertension belongs to group 1 of the pulmonary hypertension classification and should be considered in any patient with pulmonary hypertension returning from an endemic area.

Case Report: A 17-year-old patient was hospitalized for pulmonary hypertension detected during the initial assessment of viral hepatitis B-related cirrhosis with portal hypertension. The initial assessment established the diagnosis of pulmonary hypertension secondary to viral hepatitis B-cirrhosis. Read More

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November 2018
5 Reads

Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine.

Trop Med Infect Dis 2018 Nov 21;3(4). Epub 2018 Nov 21.

FIOCRUZ-Instituto Oswaldo Cruz, Laboratório de Esquistossomose Experimental, Av. Brasil, 4365, Manguinhos, Rio de Janeiro 21045-900, Brazil.

Schistosomiasis, a disease historically associated with poverty, lack of sanitation and social inequality, is a chronic, debilitating parasitic infection, affecting hundreds of millions of people in endemic countries. Although chemotherapy is capable of reducing morbidity in humans, rapid re-infection demonstrates that the impact of drug treatment on transmission control or disease elimination is marginal. In addition, despite more than two decades of well-executed control activities based on large-scale chemotherapy, the disease is expanding in many areas including Brazil. Read More

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November 2018
2 Reads

Population level changes in schistosome specific antibody levels following chemotherapy.

Parasite Immunol 2018 Nov 22:e12604. Epub 2018 Nov 22.

Centre for Immunity, Infection & Evolution, and Usher Institute of Population Health Sciences & Informatics, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK.

Aims: Previous studies have reported that chemotherapy of schistosomiasis by praziquantel in humans boosts protective antibody responses against S. mansoni and S. haematobium. Read More

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November 2018
4 Reads

Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial.

Phytomedicine 2018 Dec 10;51:233-240. Epub 2018 Oct 10.

Department of Biology and Biotechnology, Worcester Polytechnic Institute, USA.

Background And Objective: Schistosomiasis (bilharzia), a serious neglected tropical disease affecting millions, has few cost-effective treatments, so two Artemisia wormwood species, A. annua and A. afra, were compared with the current standard praziquantel (PZQ) treatment in an 800 patient clinical trial, August-November of 2015. Read More

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December 2018

Never seen before? Opisthorchiasis and Clonorchiasis.

Z Gastroenterol 2018 Dec 22;56(12):1513-1520. Epub 2018 Nov 22.

Department of Ultrasound, Zhongshan Hospital, Fudan University, 200032 Shanghai, China.

Parasitic diseases are relatively rarely diagnosed and treated in Europe. Therefore, European clinicians are not familiar with their clinical and imaging features. In an era of increased human migration, it is fundamental for clinicians to be able to identify such diseases. Read More

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December 2018
6 Reads

Schistosomiasis: Snail-vector control, molecular modelling and dynamic studies of bioactive N-acetylglycoside saponins from Tetrapleura tetraptera.

Comput Biol Chem 2018 Dec 24;77:363-372. Epub 2018 Sep 24.

Institute of Theoretical and Computational Chemistry, Heinrich Heine University, Dusseldorf, Germany. Electronic address:

Schistosomiasis, a chronic neglected tropical disease caused by the Schistosoma spp. parasite, is associated with disabling patient symptoms. The new focus of the WHO roadmap on 'transmission control, wherever possible' offers drug development opportunities for intermediate-host control to prevent human-to-snail-to-human parasite transmission. Read More

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December 2018
3 Reads

Lung Involvement in Chronic Schistosomiasis with Bladder Squamous Cell Carcinoma.

Emerg Infect Dis 2018 Dec;24(12):2375-2378

We report a case of chronic Schistosoma haematobium infection with pseudometastatic pulmonary nodules and high-grade squamous cell carcinoma in a 30-year-old man in Mali. Lung biopsies revealed chronic pulmonary involvement of S. haematobium and ruled out lung metastases. Read More

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December 2018
3 Reads

Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion.

Front Immunol 2018 29;9:2492. Epub 2018 Oct 29.

School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle involving infections of an aquatic snail intermediate host and a definitive mammalian host. In humans, adult male and female worms lie within the vasculature. Read More

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October 2018
9 Reads

Diffuse large B cell lymphoma and schistosomiasis: a rare simultaneous occurrence.

Ann Hematol 2018 Nov 19. Epub 2018 Nov 19.

Pathology Unit, Ospedale di Terni, University of Perugia, Viale Tristano di Joannuccio, 05100, Terni, Italy.

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November 2018
2 Reads

Dataset on schistosomiasis control using potassium usnate against at different developmental stage and cercariae.

Data Brief 2018 Dec 27;21:1347-1351. Epub 2018 Oct 27.

Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Prof. Moraes Rego, 1235 Cidade Universitária, CEP 50670-901 Recife, PE, Brazil.

This text presents complementary data corresponding to schistosomiasis mansoni׳s vector control and toxicity on cercariae using potassium usnate. This information support our research article "Potassium Usnate Toxicity Against Embryonic Stages of the Snail and Cercariae" [1], and focuses on the analysis of the detailed data regarding the different concentrations of potassium usnate and their efficiency to mortality and non-viability and cercariae mortality etiologic agent of the disease. Read More

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December 2018
2 Reads

Advancing the Development of a Human Schistosomiasis Vaccine.

Trends Parasitol 2018 Nov 16. Epub 2018 Nov 16.

Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC, USA.

Three vaccines against human schistosomiasis are in different phases of clinical development, and a fourth is expected to enter the clinic soon. Successful introduction of an efficacious preventive human schistosomiasis vaccine will require integration into existing health systems such as those that deliver childhood vaccines or mass drug administration programs. Read More

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November 2018
4 Reads

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni.

Int J Parasitol Drugs Drug Resist 2018 Dec 13;8(3):559-570. Epub 2018 Nov 13.

The Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, SY23 3DA, Wales, UK. Electronic address:

Schistosomiasis endangers the lives of greater than 200 million people every year and is predominantly controlled by a single class chemotherapy, praziquantel (PZQ). Development of PZQ replacement (to combat the threat of PZQ insensitivity/resistance arising) or combinatorial (to facilitate the killing of PZQ-insensitive juvenile schistosomes) chemotherapies would help sustain this control strategy into the future. Here, we re-categorise two families of druggable epigenetic targets in Schistosoma mansoni, the histone methyltransferases (HMTs) and the histone demethylases (HDMs). Read More

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December 2018

Schistosoma mansoni infection and socio-behavioural predictors of HIV risk: a cross-sectional study in women from Uganda.

BMC Infect Dis 2018 Nov 19;18(1):586. Epub 2018 Nov 19.

Department of Immunology, University of Toronto, Toronto, Canada.

Background: Schistosoma mansoni infection has been associated with increased risk of HIV transmission in African women. This association might be causal or mediated through shared socio-behavioural factors and associated co-infections. We tested the latter hypothesis in a cross-sectional pilot study in a cohort of women from a S. Read More

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November 2018
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Implications from assessing environmental effects on spatio-temporal pattern of schistosomiasis in the Yangtze Basin, China.

Geospat Health 2018 11 12;13(2). Epub 2018 Nov 12.

Anhui Provincial Institute of Parasitic Diseases, Hefei.

Schistosomiasis remains a major public health problem in the South China, particularly in lake and marshland regions. Modelling the spatio-temporal pattern of schistosomiasis guides disease prevention and control programs and is a research area of growing interest. However, few attempts have been made to evaluate the changing (nonlinear) effects of environmental determinants on schistosomiasis. Read More

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November 2018
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Mapping the potential distribution of the schistosomiasis intermediate host Biomphalaria straminea in China.

Geospat Health 2018 11 9;13(2). Epub 2018 Nov 9.

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin.

Biomphalaria straminea is native to Brazil but has established a population in Guangdong Province, China. Its potential of expanding and transmitting Schistosoma mansoni is of great concern. We seek to map S. Read More

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November 2018

A Strong Humoral Immune Response Induced by a Vaccine Formulation Containing rSm29 Adsorbed to Alum Is Associated With Protection Against Reinfection in Mice.

Front Immunol 2018 2;9:2488. Epub 2018 Nov 2.

Laboratório de Biologia e Imunologia de Doenças Infeciosas e Parasitárias, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazil.

The helminth is one of main causes of human schistosomiasis, a health and economic concern in some of the world's poorest countries. Current treatment regimens can lead to serious side effects and are not suitable for breastfeeding mothers. As such, efforts have been undertaken to develop a vaccine to prevent infection. Read More

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November 2018
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