833 results match your criteria Scheuermann Kyphosis


Effect of gastric fluid aspiration on the lung microbiota of laboratory rats.

Exp Lung Res 2018 Nov 22:1-10. Epub 2018 Nov 22.

a Department of Surgery , Duke University Medical Center , Durham , North Carolina , USA.

Aim Of The Study: The pulmonary microbiota is important for both normal homeostasis and the progression of disease, and may be affected by aspiration of gastric fluid. The aim of this study was to investigate changes in the lung microbiota induced by aspiration of gastric fluid in a laboratory rat model.

Material And Methods: Using the intratracheal application method, male rats received aspiration with 0. Read More

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http://dx.doi.org/10.1080/01902148.2018.1482976DOI Listing
November 2018
3 Reads

Quality of Life Improvement Following Surgery in Adolescent Spinal Deformity Patients: A Comparison Between Scheuermann Kyphosis and Adolescent Idiopathic Scoliosis.

Spine Deform 2018 Nov - Dec;6(6):676-683

Department of Orthopaedic Surgery, Rady Children's Hospital San Diego, 3020 Children's Way, MC 5069, San Diego, CA 92123-4282, USA.

Study Design: Preoperative and two-year follow-up health-related quality of life (HRQOL) data were prospectively collected in 82 Scheuermann kyphosis (SK) and 995 adolescent idiopathic scoliosis (AIS) patients using the Scoliosis Research Society-22 patient questionnaire (SRS-22) outcomes instrument in a multicenter study. Visual analog scale (VAS) scores were also collected for the SK population.

Objectives: This study assessed changes in HRQOL prospectively and compared them to those occurring in AIS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2212134X183007
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http://dx.doi.org/10.1016/j.jspd.2018.04.009DOI Listing
January 2018
10 Reads

Validation of gallbladder absorbed radiation dose reduction simulation: human dosimetry of [F]fluortriopride.

EJNMMI Phys 2018 Oct 8;5(1):21. Epub 2018 Oct 8.

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Background: [F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson's disease, and schizophrenia. Preclinical radiation dosimetry studies found the gallbladder wall received the highest dose. A gallbladder dose reduction intervention was simulated using a novel reduction model for healthy adults following fatty-meal consumption. Read More

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https://ejnmmiphys.springeropen.com/articles/10.1186/s40658-
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http://dx.doi.org/10.1186/s40658-018-0219-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174116PMC
October 2018
6 Reads

Chromosome Y-encoded antigens associate with acute graft-versus-host disease in sex-mismatched stem cell transplant.

Blood Adv 2018 Oct;2(19):2419-2429

Center for International Blood and Marrow Transplant Research, Minneapolis, MN.

Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a curative option for blood cancers, but the coupled effects of graft-versus-tumor and graft-versus-host disease (GVHD) limit its broader application. Outcomes improve with matching at HLAs, but other factors are required to explain residual risk of GVHD. In an effort to identify genetic associations outside the major histocompatibility complex, we conducted a genome-wide clinical outcomes study on 205 acute myeloid leukemia patients and their fully HLA-A-, HLA-B-, HLA-C-, HLA-DRB1-, and HLA-DQB1-matched (10/10) unrelated donors. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018019513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177651PMC
October 2018
3 Reads

Long term prognosis of Scheuermann's disease: The association with fragility fracture - The MINOS cohort.

Bone 2018 Dec 20;117:116-122. Epub 2018 Sep 20.

INSERM UMR 1033, University of Lyon, Lyon, France. Electronic address:

The aim was to assess the association of Scheuermann's disease (SCD) with fracture risk (vertebral, peripheral) and bone mineral density (BMD) in older men. SCD was assessed on the baseline lateral spine radiographs using the Berlin criteria in 766 men aged 50-85. We evaluated the association of SCD and its diagnostic criteria with incident fracture (vertebral over 7. Read More

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http://dx.doi.org/10.1016/j.bone.2018.09.016DOI Listing
December 2018
7 Reads

Fungal resistance mediated by maize wall-associated kinase ZmWAK-RLK1 correlates with reduced benzoxazinoid content.

New Phytol 2018 Sep 4. Epub 2018 Sep 4.

Department of Plant and Microbial Biology, University of Zurich, Zollikerstrasse 107, CH-8008, Zurich, Switzerland.

Wall-associated kinases (WAKs) have recently been identified as major components of fungal and bacterial disease resistance in several cereal crop species. However, the molecular mechanisms of WAK-mediated resistance remain largely unknown. Here, we investigated the function of the maize gene ZmWAK-RLK1 (Htn1) that confers quantitative resistance to northern corn leaf blight (NCLB) caused by the hemibiotrophic fungal pathogen Exserohilum turcicum. Read More

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http://dx.doi.org/10.1111/nph.15419DOI Listing
September 2018
2 Reads

Intraspinal Anomalies in Individuals with Scheuermann's Kyphosis: Is the Routine Use of Magnetic Resonance Imaging Necessary for Preoperative Evaluation?

Asian Spine J 2018 Aug 27;12(4):697-702. Epub 2018 Jul 27.

Department of Orthopaedics and Traumatology, Emsey Hospital, Istanbul, Turkey.

Study Design: Retrospective study.

Purpose: This study aimed to determine the incidence of intraspinal pathologies (ISPs) in individuals with Scheuermann's kyphosis (SK) and to validate whether the routine use of magnetic resonance imaging (MRI) is necessary for preoperative evaluation.

Overview Of Literature: There are several studies on the necessity of routine MRI screening and prevalence of ISPs related to different types of scoliosis have been conducted. Read More

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http://dx.doi.org/10.31616/asj.2018.12.4.697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068416PMC
August 2018
9 Reads

Severe hyperkyphosis reduces the aerobic capacity and maximal exercise tolerance in patients with Scheuermann disease.

Spine J 2018 Jul 17. Epub 2018 Jul 17.

Department of Orthopedic Surgery, Hospital Ramón y Cajal, Ctra. de Colmenar Viejo, km. 9.100, Madrid 28034, Spain.

Background Context: The evaluation of ventilatory functional restrictions during a maximal exercise tolerance test in patients with Scheuermann disease has never been described.

Purpose: This study evaluated the respiratory functional capacity of patients with Scheuermann disease compared to healthy adolescents matched in age.

Study Design/setting: Prospective comparative study. Read More

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http://dx.doi.org/10.1016/j.spinee.2018.07.002DOI Listing
July 2018
8 Reads

Adaptation of the Scoliosis Research Society-22 Questionnaire for the Hebrew Language: Transcultural Adaptation and Reliability Analysis.

Spine Deform 2018 Jul - Aug;6(4):397-402

Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences at Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address:

Study Design: A cross-cultural adaptation and reliability study.

Objective: To perform cross-cultural adaptation and evaluate the reliability and validity of the Hebrew version of the Scoliosis Research Society-22 (SRS-22) questionnaire.

Summary Of Background Data: The SRS-22 validated in different languages is used in assessing health-related quality of life of patients with scoliosis. Read More

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http://dx.doi.org/10.1016/j.jspd.2017.12.005DOI Listing
August 2017
2 Reads

VDJServer: A Cloud-Based Analysis Portal and Data Commons for Immune Repertoire Sequences and Rearrangements.

Front Immunol 2018 8;9:976. Epub 2018 May 8.

Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Background: Recent technological advances in immune repertoire sequencing have created tremendous potential for advancing our understanding of adaptive immune response dynamics in various states of health and disease. Immune repertoire sequencing produces large, highly complex data sets, however, which require specialized methods and software tools for their effective analysis and interpretation.

Results: VDJServer is a cloud-based analysis portal for immune repertoire sequence data that provide access to a suite of tools for a complete analysis workflow, including modules for preprocessing and quality control of sequence reads, V(D)J gene segment assignment, repertoire characterization, and repertoire comparison. Read More

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http://dx.doi.org/10.3389/fimmu.2018.00976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953328PMC
May 2018
5 Reads

Posterior-only versus combined anterior/posterior fusion in Scheuermann disease: a large retrospective study.

Eur Spine J 2018 Sep 19;27(9):2322-2330. Epub 2018 May 19.

Groupe Hospitalier Paris Saint-Joseph, 185, rue Raymond Losserand, 75014, Paris, France.

Purpose: The literature shows controversies concerning surgical treatment of Scheuermann's kyphosis between posterior-only fixation and combined anterior/posterior fusion. The aim of this study is to compare the clinical and radiological results and the rate of complications between these two techniques.

Methods: We performed a multicentric retrospective review of 131 patients who underwent primary fusion for Scheuermann's kyphosis divided into two groups: 67 patients operated via posterior approach only and 64 operated via combined anterior/posterior approach. Read More

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http://dx.doi.org/10.1007/s00586-018-5633-xDOI Listing
September 2018
5 Reads

Scheuermann's Disease with Extensive Involvement of Dorsolumbar Spine.

Indian J Pediatr 2018 09 3;85(9):818-819. Epub 2018 May 3.

Department of Pediatrics, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi, 110 095, India.

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http://dx.doi.org/10.1007/s12098-018-2675-3DOI Listing
September 2018
1 Read

Cell type discovery using single-cell transcriptomics: implications for ontological representation.

Hum Mol Genet 2018 May;27(R1):R40-R47

J. Craig Venter Institute, La Jolla, CA 92037, USA.

Cells are fundamental function units of multicellular organisms, with different cell types playing distinct physiological roles in the body. The recent advent of single-cell transcriptional profiling using RNA sequencing is producing 'big data', enabling the identification of novel human cell types at an unprecedented rate. In this review, we summarize recent work characterizing cell types in the human central nervous and immune systems using single-cell and single-nuclei RNA sequencing, and discuss the implications that these discoveries are having on the representation of cell types in the reference Cell Ontology (CL). Read More

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http://dx.doi.org/10.1093/hmg/ddy100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946857PMC
May 2018
10 Reads

Is the inclinometer a valid measure of thoracic kyphosis? A cross-sectional study.

Braz J Phys Ther 2018 Jul - Aug;22(4):310-317. Epub 2018 Mar 6.

The University of Newcastle, School of Health Sciences, Discipline of Physiotherapy, Callaghan, NSW, Australia.

Background: Radiographs are used to monitor thoracic kyphosis in individuals with certain pathologies (e.g. osteoporosis), exposing patients to potentially harmful radiation. Read More

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http://dx.doi.org/10.1016/j.bjpt.2018.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095094PMC
March 2018
2 Reads

Reciprocal Changes in Sagittal Alignment With Operative Treatment of Adolescent Scheuermann Kyphosis-Prospective Evaluation of 96 Patients.

Spine Deform 2018 Mar - Apr;6(2):177-184

Rady Children's Hospital San Diego, 3020 Children's Way, San Diego, CA 92123, USA.

Introduction: Sagittal alignment abnormalities in Scheuermann kyphosis (SK) strongly correlate with quality of life measures. The changes in spinopelvic parameters after posterior spinal fusion have not been adequately studied. This study is to evaluate the reciprocal changes in spinopelvic parameters following surgical correction for SK. Read More

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http://dx.doi.org/10.1016/j.jspd.2017.07.001DOI Listing
December 2018
3 Reads

Effects of Lumacaftor-Ivacaftor Therapy on Cystic Fibrosis Transmembrane Conductance Regulator Function in Phe508del Homozygous Patients with Cystic Fibrosis.

Am J Respir Crit Care Med 2018 Jun;197(11):1433-1442

5 Clinic of Pediatric Pneumology, Allergology, and Neonatology and.

Rationale: The combination of the CFTR (cystic fibrosis transmembrane conductance regulator) corrector lumacaftor with the potentiator ivacaftor has been approved for the treatment of patients with cystic fibrosis homozygous for the Phe508del CFTR mutation. The phase 3 trials examined clinical outcomes but did not evaluate CFTR function in patients.

Objectives: To examine the effect of lumacaftor-ivacaftor on biomarkers of CFTR function in Phe508del homozygous patients with cystic fibrosis aged 12 years and older. Read More

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http://dx.doi.org/10.1164/rccm.201710-1983OCDOI Listing
June 2018
15 Reads

Cell type discovery and representation in the era of high-content single cell phenotyping.

BMC Bioinformatics 2017 12 21;18(Suppl 17):559. Epub 2017 Dec 21.

J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA, 92037, USA.

Background: A fundamental characteristic of multicellular organisms is the specialization of functional cell types through the process of differentiation. These specialized cell types not only characterize the normal functioning of different organs and tissues, they can also be used as cellular biomarkers of a variety of different disease states and therapeutic/vaccine responses. In order to serve as a reference for cell type representation, the Cell Ontology has been developed to provide a standard nomenclature of defined cell types for comparative analysis and biomarker discovery. Read More

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http://dx.doi.org/10.1186/s12859-017-1977-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763450PMC
December 2017
9 Reads

Selection of distal fusion level in terms of distal junctional kyphosis in Scheuermann kyphosis. A comparison of 3 methods.

Acta Orthop Traumatol Turc 2018 Jan 28;52(1):7-11. Epub 2017 Dec 28.

Acibadem University Atakent Hospital, Department of Orthopaedics and Traumatology, Istanbul, Turkey.

Objective: The aim of this study was to investigate the effect of distal fusion level selection on the distal junctional kyphosis (DJK) in Scheuermann kyphosis (SK) patients who underwent posterior fusion.

Methods: Thirty-nine SK patients who underwent posterior fusion with a minimum follow-up of 3 years were retrospectively evaluated. According to the distal fusion level, patients were divided into 3 groups. Read More

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http://dx.doi.org/10.1016/j.aott.2017.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136323PMC
January 2018
27 Reads

Adding Satellite Rods to Standard Two-rod Construct With the Use of Duet Screws: An Effective Technique to Improve Surgical Outcomes and Preventing Proximal Junctional Kyphosis in Posterior-Only Correction of Scheuermann Kyphosis.

Spine (Phila Pa 1976) 2018 07;43(13):E758-E765

Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Study Design: A retrospective matched-cohort comparative study.

Objective: The aim of this study was to compare the surgical results after the use of duet screw based satellite rods and bilateral satellite rods (S-RC) versus a standard two-rod construct (2-RC) across osteotomy sites in a matched cohort with Scheuermann kyphosis (SK).

Summary Of Background Data: Multiple Ponte osteotomies are frequently employed to correct SK via a posterior-only approach, with a 2-RC across the osteotomy sites. Read More

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http://dx.doi.org/10.1097/BRS.0000000000002489DOI Listing
July 2018
3 Reads

Severe rigid Scheuermann kyphosis in adult patients; correction with posterior-only approach.

Musculoskelet Surg 2018 Dec 17;102(3):257-260. Epub 2017 Nov 17.

Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Scheuermann kyphosis is the most common structural kyphosis among adolescence and young people. Surgical treatment may be performed through combined anterior and posterior or posterior-only approaches; to our knowledge, the efficacy of posterior-only approach as less invasive procedure is not well studied in case of severe rigid Scheuermann kyphosis.

Materials And Methods: Eighteen patients with severe rigid Scheuermann kyphosis operated through only posterior approach from 2013 to 2016 were evaluated. Read More

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http://dx.doi.org/10.1007/s12306-017-0526-4DOI Listing
December 2018
2 Reads

Automated Analysis of Clinical Flow Cytometry Data: A Chronic Lymphocytic Leukemia Illustration.

Clin Lab Med 2017 12;37(4):931-944

Department of Informatics, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037, USA.

Flow cytometry is used in cell-based diagnostic evaluation for blood-borne malignancies including leukemia and lymphoma. The current practice for cytometry data analysis relies on manual gating to identify cell subsets in complex mixtures, which is subjective, labor-intensive, and poorly reproducible. This article reviews recent efforts to develop, validate, and disseminate automated computational methods and pipelines for cytometry data analysis that could help overcome the limitations of manual analysis and provide for efficient and data-driven diagnostic applications. Read More

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http://dx.doi.org/10.1016/j.cll.2017.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766345PMC
December 2017
13 Reads

Single-stage deformity correction in children with neurogenic kyphoscoliosis: nuances and a proposal for risk stratification.

Neurosurg Focus 2017 Oct;43(4):E13

Department of Spine Surgery, Sparsh Hospital, Bangalore, India; and.

OBJECTIVE Neurogenic kyphoscoliosis in pediatric patients has varied causes and diverse management options. The most common management strategy is to stage the orthopedic and neurosurgical aspects of the correction at an interval of 3-6 months from each other. The aim of this study was to report the authors' experience with correction of deformity in children with associated neurological abnormalities requiring intervention as a single-stage surgical treatment. Read More

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http://dx.doi.org/10.3171/2017.7.FOCUS17348DOI Listing
October 2017
9 Reads

Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis.

Sci Rep 2017 Sep 21;7(1):12094. Epub 2017 Sep 21.

Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, D-10117, Berlin, Germany.

Immunity in infection, inflammation and malignancy differs markedly in man and mouse. Still, we learn about human immunity in large extent from experimental mouse models. We propose a novel data integration approach which identifies concordant and discordant gene expression patterns of the immune responses in heterologous data sets. Read More

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http://dx.doi.org/10.1038/s41598-017-11812-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608750PMC
September 2017
12 Reads

Posterior-Only Approach with Pedicle Screws for the Correction of Scheuermann's Kyphosis.

Asian Spine J 2017 Aug 7;11(4):513-519. Epub 2017 Aug 7.

Department of Spine Surgery, Baltalimani Bone Diseases Education And Research Hospital, İstanbul, Turkey.

Study Design: Retrospective study (level of evidence: level 3).

Purpose: The purpose of this study was to evaluate the clinical and radiological results of the posterior-only approach with pedicle screws for the treatment of Scheuermann's kyphosis (SK).

Overview Of Literature: The correction of SK with instrumentation can be performed using posterior-only or combined anterior-posterior procedures. Read More

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http://dx.doi.org/10.4184/asj.2017.11.4.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573844PMC
August 2017
7 Reads

NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children.

PLoS One 2017 24;12(8):e0183027. Epub 2017 Aug 24.

Hospital for Children and Adolescents, University Leipzig, Leipzig, Saxony, Germany.

Nicotinamide phosphoribosyl transferase (NAMPT) is an inflammatory adipocytokine shown to interact in immune modulation in chronic inflammatory diseases, acute respiratory distress syndrome, sepsis, cancer and obesity in adulthood. It is, however, not clear whether this association reflects a chronic elevation or acute inflammatory response. We analyzed NAMPT concentrations in distinct states of inflammation in 102 children and found consistently significantly increased NAMPT levels in subjects with acute infections. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183027PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570332PMC
October 2017
13 Reads

Evaluation and management of lower back pain in young athletes.

Transl Pediatr 2017 Jul;6(3):225-235

Department of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, USA.

Lower back pain in young athletes is a common problem. The prevalence of back pain from different causes in adolescent age group is between 20% and 30%. However, the incidence of low back pain in young athletes varies widely in different sports. Read More

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http://dx.doi.org/10.21037/tp.2017.06.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532202PMC
July 2017
5 Reads

Can MRI Predict Flexibility in Scheuermann Kyphosis Patients?

Clin Spine Surg 2017 Aug;30(7):E938-E941

*The Centre for Spinal Studies and Surgery, QMC, Nottingham University Hospitals NHS Trust, Nottingham, UK †Department of Neurosurgery and Neurooncology, First School of Medicine, Charles University and Military University Hospital Prague ‡Department of Anesthesiology and Intensive Care Medicine, Hospital Kralovske Vinohrady, Prague, Czech Republic.

Study Design: Retrospective, blinded analysis of imaging studies.

Objective: The aim of this study is compare the use of magnetic resonance imaging (MRI) to lateral radiograph using bolster in the evaluation of Scheuermann kyphosis (SK) curve flexibility measurement.

Summary And Background Data: The flexibility of the thoracic curve [thoracic kyphosis (TK)] in SK is of primary importance in its preoperative planning. Read More

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http://dx.doi.org/10.1097/BSD.0000000000000346DOI Listing
August 2017
11 Reads

Successful brace treatment of Scheuermann's kyphosis with different angles.

J Craniovertebr Junction Spine 2017 Apr-Jun;8(2):136-143

Department of Orthopedic Surgery, Al Zahra Educational Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Scheuermann's disease is regarded as the most common cause of structural hyperkyphosis within adolescents without any proper treatment. It may lead to progressive deformity and back pain which influences patient's quality of life during adolescence and adulthood. Treatment approach to Scheuermann's kyphosis has not been clearly defined due to its different definitions and obscure natural history. Read More

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http://dx.doi.org/10.4103/jcvjs.JCVJS_38_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490348PMC
July 2017
23 Reads

Familial lumbar Scheuermann disease with idiopathic scoliosis in China: First case report.

Medicine (Baltimore) 2017 Jun;96(25):e7100

Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Rationale: Given that Scheuermann disease rarely occurs in the lumbar region and that the co-occurrence of Scheuermann disease and idiopathic scoliosis (IS) has not been reported-the etiology of Scheuermann disease and IS is not clear. In this case report, we present familaiar lumbar Scheuermann disease with IS, in a Chinese proband, who was successfully treated with surgery.

Patient Concerns: A 16-year-old boy presented at the Second XiangYa Hospital of Central South University with a chief complaint of kyphotic deformity in the lower back for 4 years and obvious lower back pain. Read More

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http://dx.doi.org/10.1097/MD.0000000000007100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484193PMC
June 2017
9 Reads
5.723 Impact Factor

ER stress disturbs SR/ER-mitochondria Ca transfer: Implications in Duchenne muscular dystrophy.

Biochim Biophys Acta Mol Basis Dis 2017 09 15;1863(9):2229-2239. Epub 2017 Jun 15.

Inserm U1046, UMR CNRS 9214, Université Montpellier, CHRU Montpellier, Montpellier, France. Electronic address:

Besides its role in calcium (Ca) homeostasis, the sarco-endoplamic reticulum (SR/ER) controls protein folding and is tethered to mitochondria. Under pathophysiological conditions the unfolded protein response (UPR) is associated with disturbance in SR/ER-mitochondria crosstalk. Here, we investigated whether ER stress altered SR/ER-mitochondria links, Ca handling and muscle damage in WT (Wild Type) and mdx mice, the murine model of Duchenne Muscular Dystrophy (DMD). Read More

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http://dx.doi.org/10.1016/j.bbadis.2017.06.009DOI Listing
September 2017
2 Reads

ISYQOL: a Rasch-consistent questionnaire for measuring health-related quality of life in adolescents with spinal deformities.

Spine J 2017 09 18;17(9):1364-1372. Epub 2017 May 18.

University of Brescia, Piazza del Mercato, 15, 25121 Brescia, Italy; IRCCS Fondazione Don Gnocchi, Via Alfonso Capecelatro, 66, 20148 Milano, Italy.

Background Context: Spinal deformities are commonly associated with poor health-related quality of life (HRQOL). Several questionnaires (eg, Scoliosis Research Society-24 [SRS-24] and Scoliosis Research Society-22 [SRS-22]) have been developed to evaluate HRQOL in these conditions. In adults as well as during growth, the HRQOL is considered one of the most relevant outcomes of both conservative and surgical treatments. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15299430173021
Publisher Site
http://dx.doi.org/10.1016/j.spinee.2017.05.022DOI Listing
September 2017
43 Reads

A Radiographic Analysis of Cervical Sagittal Alignment in Adolescent Idiopathic Cervical Kyphosis.

Clin Spine Surg 2017 Jun;30(5):E560-E566

Department of Orthopaedics ChangZheng Hospital Affiliated to Second Military Medical University, Shanghai, China.

Objective: The aim of this study was to analyze the radiologic features of adolescent idiopathic cervical kyphosis.

Summary Of Background Data: There are few previous reports about radiographic analysis of cervical sagittal alignment of adolescent idiopathic cervical kyphosis. A new method was proposed in this article to evaluate the severity of cervical kyphosis. Read More

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http://dx.doi.org/10.1097/BSD.0000000000000257DOI Listing
June 2017
16 Reads

Genetic changes found in a distinct clade of Enterovirus D68 associated with paralysis during the 2014 outbreak.

Virus Evol 2016 Jan 15;2(1):vew015. Epub 2016 Jun 15.

J. Craig Venter Institute, La Jolla, CA, USA.

Enterovirus D68 (EV-D68) caused a severe respiratory illness outbreak in the United States in 2014. Reports of acute flaccid myelitis (AFM)/paralysis (AFP) in several independent epidemiological clusters of children with detectable EV-D68 have raised concerns that genetic changes in EV-D68 could be causing increased disease severity and neurological symptoms. To explore the potential link between EV-D68 genetic variations and symptom changes, we performed a series of comparative genomic analyses of EV-D68 2014 outbreak isolate sequences using data and analytical tools in the Virus Pathogen Resource (ViPR; www. Read More

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http://dx.doi.org/10.1093/ve/vew015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426007PMC
January 2016
17 Reads

Chronic stress suppresses anti-tumor T responses and tumor regression following cancer immunotherapy in a mouse model of melanoma.

Brain Behav Immun 2017 Oct 27;65:140-149. Epub 2017 Apr 27.

Division of Immunology, Department of Biology, University of Konstanz, D-78457 Konstanz, Germany; Biotechnology Institute Thurgau (BITg) at the University of Konstanz, CH-8280 Kreuzlingen, Switzerland.

Animal tumor models and human cancer studies have provided convergent evidence that chronic psychological stress plays a decisive role in modulating anti-tumor T cell immunity. However, whether chronic stress also affects anti-cancer vaccine strategies that rely on the induction of functional tumor-specific T cells has not been investigated yet. In this study we provide direct evidence that chronic stress suppresses the therapeutic efficacy of a biodegradable poly(d,l-lactide-co-glycolide) microsphere (PLGA-MS) based cancer vaccine in a murine melanoma model. Read More

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http://dx.doi.org/10.1016/j.bbi.2017.04.021DOI Listing
October 2017
17 Reads

Analysis of cervical sagittal alignment change following correction of thoracic and thoracolumbar Scheuermann's kyphosis.

Eur Spine J 2017 08 19;26(8):2187-2197. Epub 2017 Apr 19.

The Centre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham, NG7 2UH, UK.

Purpose: To analyse pre-operative and post-operative changes of cervical sagittal alignment (CSA) in Scheuermann's kyphosis (SK) patients.

Methods: 64 SK and 33 control patients were retrospectively reviewed. Whole spine X-rays obtained at pre-op, 3 months post-op and at latest follow-up were reviewed and ten separate CSA radiological parameters were measured. Read More

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http://dx.doi.org/10.1007/s00586-017-5069-8DOI Listing
August 2017
17 Reads

Progression of untreated mild thoracic Scheuermann's kyphosis - Radiographic and functional assessment after mean follow-up of 46 years.

J Orthop Sci 2017 Jul 15;22(4):652-657. Epub 2017 Apr 15.

Orton Orthopaedic Hospital and Orton Research Institute, Orton Foundation, Tenholantie 10, PL 29, 00281, Helsinki, Finland. Electronic address:

Background: There is no data available on the radiographic development of the Scheuermann's deformity. Our purpose was to investigate radiographic deformity progression and the relation between kyphosis progression and clinical outcome in patients with untreated Scheuermann's kyphosis.

Methods: Thoracic kyphosis (Th4-Th12) was measured from standing lateral radiographs in 19 patients at baseline and after mean 46-year follow-up. Read More

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http://dx.doi.org/10.1016/j.jos.2017.03.009DOI Listing
July 2017
11 Reads

Craniosynostosis, Scheuermann's disease, and intellectual disability resembling Shprintzen-Goldberg syndrome: a report on a family over 4 generations: Case report.

Medicine (Baltimore) 2017 Mar;96(12):e6199

aLudwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, First Medical Department, Hanusch Hospital bOrthopedic Hospital of Speising, Pediatric Department, Vienna, Austria cDepartment of Neonatology, Charles Nicolle Hospital, Tunisia dDepartment of Pediatric Orthopedic Surgery, Children Hospital of Tunis, Tunisia. eInstitute of Medical Chemistry, Medical University of Vienna, Austria.

Rationale: Craniosynostosis is a disorder characterized by premature fusion of cranial sutures with subsequent development of abnormal craniofacial contour associated with variable skeletal and extra-skeletal abnormalities. In this family syndromic type of craniosynostosis was recognized and the etiology behind diverse forms of deformities have been diagnosed.

Patient Concerns: The negative impact of the disorder on the child and his family is enormous. Read More

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http://dx.doi.org/10.1097/MD.0000000000006199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371443PMC
March 2017
16 Reads

Spinal epidural lipomatosis - an easily ignored secondary intraspinal disorder in spinal kyphotic deformities.

BMC Musculoskelet Disord 2017 03 16;18(1):112. Epub 2017 Mar 16.

Department of Spine Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Background: A previous study reported a high prevalence of spinal epidural lipomatosis (SEL) in patients with Scheuermann kyphosis (SK) and suggested that it may play a role in the pathogenesis of this disease. According to our observation, however, SEL occurs in other spinal kyphotic deformities as well. The aim of this study was to test the hypothesis that SEL commonly occurs in patients with different types of kyphotic deformities as a secondary intraspinal disorder. Read More

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http://bmcmusculoskeletdisord.biomedcentral.com/articles/10.
Publisher Site
http://dx.doi.org/10.1186/s12891-017-1467-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356279PMC
March 2017
19 Reads

MRI Screening in Operative Scheuermann Kyphosis: Is it Necessary?

Spine Deform 2017 03;5(2):124-133

Department of Orthopedic Surgery, Rady Children's Hospital, 3020 Children's Way, San Diego, CA 92123, USA.

Study Design: Patients with preoperative spine magnetic resonance imaging (MRI) studies from a prospective multicenter study of operative adolescent Scheuermann kyphosis (SK).

Objectives: To investigate the usefulness of MRI screening in operative planning for SK surgeries.

Summary Of Background Data: Neural axis abnormalities in operative SK have not been previously studied with MRI screening, despite its use. Read More

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http://dx.doi.org/10.1016/j.jspd.2016.10.008DOI Listing
March 2017
6 Reads

What are the Indications for Spinal Fusion Surgery in Scheuermann Kyphosis?

J Pediatr Orthop 2017 Jan 30. Epub 2017 Jan 30.

*Department of Orthopaedic Surgery, University of Minnesota, Minneapolis **Mayo Clinic, Rochester, MN †Edwards Life Sciences, Irvine, CA ‡St. Justine's Hospital, Montreal, QC, Canada §Texas Scottish Rite Hospital for Children, Dallas, TX ∥Boston Children's Hospital, Boston, MA ¶Columbia University, New York, NY #Children's Hospital, Aurora, CO.

Background: Surgical indications for Scheuermann kyphosis are variable. We sought to evaluate the characteristics of patients undergoing operative versus nonoperative treatment of Scheuermann kyphosis to better understand current practices and the factors which contribute to the decision for surgical management.

Methods: Multicenter prospective cohort study. Read More

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http://dx.doi.org/10.1097/BPO.0000000000000931DOI Listing
January 2017
26 Reads

Spinal cord ischemia in Scheuermann disease: A report of three cases.

Joint Bone Spine 2017 May 25;84(3):345-348. Epub 2017 Jan 25.

Service de rééducation et réadaptation de l'appareil locomoteur et des pathologies du rachis, hôpital Cochin, AP-HP, 75014 Paris, France; Inserm U1153, faculté de médecine Paris-Descartes, 75006 Paris, France.

Background: Neurological complications in Scheuermann's disease are rare but serious.

Case Reports: We report three cases of severe neurological deficit due to medullar ischemia attributable to the compression of a radiculomedullar artery by thoracic (two cases) and lumbar (one case) disc herniations associated with Scheuermann's disease. They were not treated surgically because of the absence of direct spinal cord compression or definitive spinal cord ischemia. Read More

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http://dx.doi.org/10.1016/j.jbspin.2016.10.007DOI Listing
May 2017
7 Reads

Distal junctional kyphosis in patients with Scheuermann's disease: a retrospective radiographic analysis.

Eur Spine J 2017 03 31;26(3):913-920. Epub 2016 Dec 31.

Center for Spinal Studies, Queens Medical Center, Nottingham University, Derby Road, Nottingham, NG7 2UH, UK.

Purpose: To investigate the relationship between preoperative and postoperative spinopelvic alignment and occurrence of DJK/DJF.

Study Design/setting: This was a retrospective observational cohort study.

Patient Sample: The sample included 40 patients who underwent posterior correction of SK from January 2006 to December 2014. Read More

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http://dx.doi.org/10.1007/s00586-016-4924-3DOI Listing
March 2017
11 Reads

A Phylogeny-Based Global Nomenclature System and Automated Annotation Tool for H1 Hemagglutinin Genes from Swine Influenza A Viruses.

mSphere 2016 Nov-Dec;1(6). Epub 2016 Dec 14.

Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, Ames, Iowa, USA.

The H1 subtype of influenza A viruses (IAVs) has been circulating in swine since the 1918 human influenza pandemic. Over time, and aided by further introductions from nonswine hosts, swine H1 viruses have diversified into three genetic lineages. Due to limited global data, these H1 lineages were named based on colloquial context, leading to a proliferation of inconsistent regional naming conventions. Read More

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http://dx.doi.org/10.1128/mSphere.00275-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156671PMC
December 2016
23 Reads

Radiological imaging findings of scheuermann disease.

World J Radiol 2016 Nov;8(11):895-901

Erkan Gokce, Department of Radiology, School of Medicine, Gaziosmanpaşa University, 60100 Tokat, Turkey.

Aim: To find accompanying anomalies of typical and atypical Scheuermann's disease (SD) is reported in the present study.

Methods: Study included 20 patients (16 men and 4 women) who had radiological imaging radiography, magnetic resonance imaging (MRI) and computed tomography, if available, due to back pain, curved back and low back pain in November 2011-February 2016 period. Patients were categorized into typical and atypical patterns based on the region involved. Read More

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http://dx.doi.org/10.4329/wjr.v8.i11.895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120249PMC
November 2016
6 Reads

Polymethylmethacrylate Entrapped in Inferior Vena Cava Filter After a Scheuermann Kyphosis Revision Surgery.

Spine Deform 2015 Nov 28;3(6):604-607. Epub 2015 Oct 28.

The Maryland Spine Center, Mercy Medical Center, Baltimore, MD 21202, USA.

Study Design: Case report.

Objectives: To review and expose the rare occurrence of prophylactic polymethylmethacrylate becoming trapped in an inferior vena cava (IVC) filter following lumbar spine revision surgery in a patient with Scheuermann's kyphosis.

Methods: Intraoperative reports, progress notes, and imaging were reviewed for a patient who underwent an initial surgery for Scheuermann's kyphosis correction, a subsequent revision surgery for a fracture sustained during the post-operative period, and an IVC filter removal procedure. Read More

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http://dx.doi.org/10.1016/j.jspd.2015.03.004DOI Listing
November 2015
10 Reads

Meeting report: 29th International Conference on Antiviral Research in La Jolla, CA, USA.

Antiviral Res 2017 01 1;137:23-40. Epub 2016 Nov 1.

Vere Hodge Antivirals Ltd, Old Denshott, Leigh, Reigate, Surrey, UK. Electronic address:

The 29th International Conference on Antiviral Research (ICAR) was held in La Jolla, CA, USA from April 17 to 21, 2016. This report opens with a tribute to the late Chris McGuigan, a Past-President of ISAR, then continues with summaries of the principal invited lectures. Doug Richman (Elion Award) investigated HIV resistance, Bob Vince (Holý Award) showed how carbocyclic nucleoside analogs led to abacavir and Jerome Deval (Prusoff Award) explained how his group chose to seek a nucleoside analog to treat RSV. Read More

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http://dx.doi.org/10.1016/j.antiviral.2016.10.014DOI Listing
January 2017
6 Reads

Conservative treatment in Scheuermann's kyphosis: comparison between lateral curve and variation of the vertebral geometry.

Scoliosis Spinal Disord 2016 14;11(Suppl 2):33. Epub 2016 Oct 14.

U.O.C. of Orthopedics and Traumatology, Children's Hospital Bambino Gesù, Institute of Scientific Research, Rome, 00165 Italy ; University of Cassino, Cassino, (FR) 03043 Italy.

Background: Conservative treatment in the Scheuermann's kyphosis obtain, during skeletal growth, remodelling of the deformed vertebras. In a previous paper on Scheuermann's kyphosis, we have studied the geometry variations of all vertebrae included in the curve, before and after the treatment. The purpose of this study was to confirm the effectiveness of conservative treatment in Scheuermann's kyphosis and was to evaluate and compare the variation of the vertebral geometry with the curve trend in Cobb degrees, before and after conservative treatment. Read More

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http://dx.doi.org/10.1186/s13013-016-0089-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073405PMC
October 2016
15 Reads

Bracing for Adolescent Idiopathic Scoliosis (AIS) and Scheuermann Kyphosis: the issue of overtreatment in Greece.

Scoliosis Spinal Disord 2016 14;11(Suppl 2):30. Epub 2016 Oct 14.

Scoliosis Spine Laser Centre, Athens, 18346 Greece.

Background: Most recent publications have provided evidence for brace treatment in spinal deformities. The purpose of this study was to evaluate the rate of overtreatment for AIS and Kyphosis in Greece, according to the Society on Scoliosis Orthopedic Rehabilitation Treatment (SOSORT) and the Scoliosis Research Society (SRS) guidelines for brace treatment. To date, this is the first study to investigate overtreatment percentage in a group of patients with spinal deformities. Read More

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http://dx.doi.org/10.1186/s13013-016-0095-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073434PMC
October 2016
11 Reads

Rates and risk factors associated with unplanned hospital readmission after fusion for pediatric spinal deformity.

Spine J 2017 03 17;17(3):369-379. Epub 2016 Oct 17.

Department of Orthopædic Surgery, UCSF, 500 Parnassus Ave, MU 320-W, San Francisco, CA 94143, USA. Electronic address:

Background Context: Short-term readmission rates are becoming widely used as a quality and performance metric for hospitals. Data on unplanned short-term readmission after spine fusion for deformity in pediatric patients are limited.

Purpose: To characterize the rate and risk factors for short-term readmission after spine fusion for deformity in pediatric patients. Read More

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http://dx.doi.org/10.1016/j.spinee.2016.10.008DOI Listing
March 2017
15 Reads