934 results match your criteria Scheuermann Kyphosis

The Hereditary Nature of Adolescent Spinal Deformities-A study of over 600,000 adolescents.

Spine (Phila Pa 1976) 2022 Apr 21. Epub 2022 Apr 21.

Medical Corps, Israel Defense Forces, Ramat-Gan, Israel.

Study Design: A cross-sectional study.

Objective: We designed this study to investigate the risk for spinal deformity among individuals whose parents had a spinal deformity.

Summary Of Background Data: Adolescent idiopathic scoliosis and Scheuermann Kyphosis are common adolescent spinal deformities (ASD) with a significant impact on public health. Read More

View Article and Full-Text PDF

Genomic evolution of the Coronaviridae family.

Virology 2022 May 30;570:123-133. Epub 2022 Mar 30.

Department of Informatics, J. Craig Venter Institute, La Jolla, CA, 92037, USA; Department of Pathology, University of California, San Diego, CA, 92093, USA; Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA; Global Virus Network, Baltimore MD, 21201, USA. Electronic address:

The current outbreak of coronavirus disease-2019 (COVID-19) caused by SARS-CoV-2 poses unparalleled challenges to global public health. SARS-CoV-2 is a Betacoronavirus, one of four genera belonging to the Coronaviridae subfamily Orthocoronavirinae. Coronaviridae, in turn, are members of the order Nidovirales, a group of enveloped, positive-stranded RNA viruses. Read More

View Article and Full-Text PDF

Defining the risk of SARS-CoV-2 variants on immune protection.

Nature 2022 Mar 31. Epub 2022 Mar 31.

Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.

The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or vaccination. To address the public health threat caused by the increasing SARS-CoV-2 genomic diversity, the National Institute of Allergy and Infectious Diseases within the National Institutes of Health established the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme. This effort was designed to provide a real-time risk assessment of SARS-CoV-2 variants that could potentially affect the transmission, virulence, and resistance to infection- and vaccine-induced immunity. Read More

View Article and Full-Text PDF

[Scheuermann's disease].

Orthopade 2022 Apr 15;51(4):339-348. Epub 2022 Mar 15.

Klinik für Orthopädie (Friedrichsheim), Universitätsklinikum Frankfurt, Marienburgstr. 2, 60528, Frankfurt am Main, Deutschland.

Scheuermann's disease represents the second most common deformity of the growing spine after the various forms of scoliosis. In cases of early diagnosis and mild kyphotic deformity conservative treatment with a brace and physiotherapy shows very good results; however, in cases of neurologic deficits, curve progression despite conservative treatment and increasing pain symptoms with a Stagnara angle of more than 70-75°, surgical treatment is meaningful. The surgical strategy can include posterior spondylodesis with prior anterior release or posterior instrumentation with posterior column osteotomy depending on the surgeon's experience. Read More

View Article and Full-Text PDF

Delayed antibiotic prescribing to reduce antibiotic use: an urgent care practice change.

BMJ Open Qual 2022 03;11(1)

Grand Canyon University College of Nursing and Health Care Professions, Phoenix, Arizona, USA.

Background: Antibiotic overuse threatens global health, food security and human development through the development of antibiotic resistance. Antibiotic resistance is associated with worse clinical outcomes and increased healthcare costs. Studies suggest urgent cares exceed the national average for inappropriate antibiotic use associated with maintaining patient satisfaction. Read More

View Article and Full-Text PDF

Osteochondrosis and other lesions in all intervertebral, articular process and rib joints from occiput to sacrum in pigs with poor back conformation, and relationship to juvenile kyphosis.

BMC Vet Res 2022 Jan 18;18(1):44. Epub 2022 Jan 18.

Norsvin SA, Storhamargata 44, 2317, Hamar, Norway.

Background: Computed tomography (CT) is used to evaluate body composition and limb osteochondrosis in selection of breeding boars. Pigs also develop heritably predisposed abnormal curvature of the spine including juvenile kyphosis. It has been suggested that osteochondrosis-like changes cause vertebral wedging and kyphosis, both of which are identifiable by CT. Read More

View Article and Full-Text PDF
January 2022

Selection of the optimal distal fusion level for Scheuermann kyphosis with different curve patterns: when can we stop above the sagittal stable vertebra?

Eur Spine J 2022 Jan 17. Epub 2022 Jan 17.

Division of Spine Surgery, Department of Orthopedic Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.

Purpose: To investigate the optimal lowest instrumented vertebra (LIV) in the treatment of Scheuermann kyphosis (SK) with different curve patterns.

Methods: Fifty-two SK patients who underwent posterior surgery between January 2010 and December 2017 with a minimum follow-up of 2 years were retrospectively reviewed. Patients were divided into two groups based on the curve pattern: the Scheuermann thoracic kyphosis (STK group) or Scheuermann thoracolumbar kyphosis (STLK group). Read More

View Article and Full-Text PDF
January 2022

Posterior Reversible Encephalopathy Syndrome in the Setting of Asparaginase-associated Pancreatitis in 2 Pediatric Patients With Acute Leukemia.

J Pediatr Hematol Oncol 2022 Apr;44(3):e709-e712

Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center.

Asparaginase, a critical component of current pediatric acute leukemia treatment protocols, is associated with a number of serious side effects, one of which is pancreatitis. Pancreatitis can result in significant morbidity and mortality from necrosis, pseudocyst formation, hemorrhage, systemic inflammation, intestinal perforation, and sepsis. Another rare complication of pancreatitis is posterior reversible encephalopathy syndrome, likely mediated by systemic inflammation secondary to pancreatic autodigestion and proinflammatory cytokine-mediated vascular endothelial damage. Read More

View Article and Full-Text PDF

Effects of Elexacaftor/Tezacaftor/Ivacaftor Therapy on CFTR Function in Patients with Cystic Fibrosis and One or Two Alleles.

Am J Respir Crit Care Med 2022 03;205(5):540-549

Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine and Cystic Fibrosis Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

The CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to improve clinical outcomes and sweat chloride concentration in patients with cystic fibrosis (CF) and one or two alleles. However, the effect of ELX/TEZ/IVA on CFTR function in the airways and intestine has not been studied. To assess the effect of ELX/TEZ/IVA on CFTR function in airway and intestinal epithelia in patients with CF and one or two alleles aged 12 years and older. Read More

View Article and Full-Text PDF

Stabilizing Ryanodine Receptors Improves Left Ventricular Function in Juvenile Dogs With Duchenne Muscular Dystrophy.

J Am Coll Cardiol 2021 12;78(24):2439-2453

Phymedexp INSERM, CNRS, Université de Montpellier, CHRU Montpellier, France. Electronic address:

Background: Duchenne muscular dystrophy is associated with progressive deterioration in left ventricular (LV) function. The golden retriever muscular dystrophy (GRMD) dog model recapitulates the pathology and clinical manifestations of Duchenne muscular dystrophy. Importantly, they develop progressive LV dysfunction starting at early age. Read More

View Article and Full-Text PDF
December 2021

Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response.

Front Immunol 2021 29;12:690470. Epub 2021 Oct 29.

Department of Informatics, J. Craig Venter Institute, La Jolla, CA, United States.

Vaccination to prevent infectious disease is one of the most successful public health interventions ever developed. And yet, variability in individual vaccine effectiveness suggests that a better mechanistic understanding of vaccine-induced immune responses could improve vaccine design and efficacy. We have previously shown that protective antibody levels could be elicited in a subset of recipients with only a single dose of the hepatitis B virus (HBV) vaccine and that a wide range of antibody levels were elicited after three doses. Read More

View Article and Full-Text PDF
December 2021

Corticosteroid treatment in COVID-19 modulates host inflammatory responses and transcriptional signatures of immune dysregulation.

J Leukoc Biol 2021 12 3;110(6):1225-1239. Epub 2021 Nov 3.

Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease-2019 (COVID-19), a respiratory disease that varies in severity from mild to severe/fatal. Several risk factors for severe disease have been identified, notably age, male sex, and pre-existing conditions such as diabetes, obesity, and hypertension. Several advancements in clinical care have been achieved over the past year, including the use of corticosteroids (e. Read More

View Article and Full-Text PDF
December 2021

Surgical Procedures Used for Correction of Scheuermann's Kyphosis: A Meta-Analysis.

Qingshan Li

Pain Res Manag 2021;2021:2142964. Epub 2021 Oct 23.

Fourth Department of Orthopedics, Handan Central Hospital of Hebei Province, Handan 056001, China.

Objectives: Scheuermann's kyphosis can cause severe back pain and cosmetic disorders to patients. Previous studies on surgical procedure selection for correction of Scheuermann's kyphosis have drawn controversial conclusions. Here, a meta-analysis was performed to figure out a better way between anterior-posterior (AP) combined procedures and posterior-only (PO) procedures. Read More

View Article and Full-Text PDF
January 2022

Specific Inhibitor of Placental Alkaline Phosphatase Isolated from a DNA-Encoded Chemical Library Targets Tumor of the Female Reproductive Tract.

J Med Chem 2021 11 28;64(21):15799-15809. Epub 2021 Oct 28.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.

Placental alkaline phosphatase (PLAP) is an abundant surface antigen in the malignancies of the female reproductive tract. Nevertheless, the discovery of PLAP-specific small organic ligands for targeting applications has been hindered by ligand cross-reactivity with the ubiquitous tissue non-specific alkaline phosphatase (TNAP). In this study, we used DNA-encoded chemical libraries to discover a potent (IC = 32 nM) and selective PLAP inhibitor, with no detectable inhibition of TNAP activity. Read More

View Article and Full-Text PDF
November 2021

Cardiorespiratory function of patients undergoing surgical correction of Scheuermann's hyperkyphosis.

Sci Rep 2021 10 11;11(1):20138. Epub 2021 Oct 11.

Department of Orthopedic Surgery and Traumatology, Hospital Infanta Cristina, Badajoz, Spain.

The aim of this study was to analyze the impact of surgical correction of the thoracic deformity on the cardiorespiratory function of patients with moderate-severe Scheuermann's hyperkyphosis (SK). A series of 23 adolescents with SK who underwent surgery through an only posterior approach using all pedicle screw constructs were included in the study. Cardiorespiratory parameters were measured during a maximal exercise tolerance test before and 2 years after surgery. Read More

View Article and Full-Text PDF
October 2021

Scheuermann Kyphosis Patients Have a Similar Revision and Infection Rate to Adolescent Idiopathic Scoliosis Patients.

Spine (Phila Pa 1976) 2022 04;47(7):E290-E295

St. George's University Hospitals, London, UK.

Study Design: Multicenter retrospective review.

Objective: This study aims to address major postoperative complications associated with Scheuermann kyphosis (SK) when compared with adolescent idiopathic scoliosis (AIS) in a large population matched by demographic characteristics, levels fused and operative technique.

Summary Of Background Data: Prior studies have found that SK patients are 3. Read More

View Article and Full-Text PDF

Long-term outcome after surgical treatment of Scheuermann's Kyphosis (SK).

Spine Deform 2022 03 17;10(2):387-397. Epub 2021 Sep 17.

Park Hospital, Nottingham, UK.

Study Design: A retrospective observational cohort study with a minimum follow-up of 10 years of patients who underwent surgery for Scheurmann Kyphosis (SK).

Objective: Evaluate the long-term clinical and radiological outcome of patients with SK who either underwent combined anterior-posterior surgery or posterior instrumented fusion alone. There is paucity of literature for long-term outcome studies on SK. Read More

View Article and Full-Text PDF

Sagittal Plane Alignment and Functional Outcomes Following Surgery for Scheuermann Kyphosis.

Rev Bras Ortop (Sao Paulo) 2021 Aug 30;56(4):446-452. Epub 2021 Aug 30.

Unidade de Anatomia, Centro Hospitalar Universitário de São João, Porto, Portugal.

 To evaluate and correlate the pelvic parameters, the sagittal balance (SB), and the functional outcome of the patients submitted to surgical treatment for Scheuermann hyperkyphosis (SK).  Patients submitted to surgery between January 2005 and December 2016 were included. The following radiographic measurements were obtained: thoracic kyphosis (TK); lumbar lordosis (LL); SB; pelvic incidence (PI); pelvic tilt (PT); and sacral slope (SS). Read More

View Article and Full-Text PDF

Contribution of postoperative vertebral remodeling to reversal of vertebral wedging and prevention of correction loss in patients with adolescent Scheuermann's kyphosis.

J Neurosurg Spine 2021 Jul 30;35(4):486-494. Epub 2021 Jul 30.

Objective: This study aimed to investigate reversal of vertebral wedging and to evaluate the contribution of vertebral remodeling to correction maintenance in patients with adolescent Scheuermann's kyphosis (SK) after posterior-only instrumented correction.

Methods: A retrospective cohort study of patients with SK was performed. In total, 45 SK patients aged 10-20 years at surgery were included. Read More

View Article and Full-Text PDF

Standardization of assay representation in the Ontology for Biomedical Investigations.

Database (Oxford) 2021 07;2021

Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.

The Ontology for Biomedical Investigations (OBI) underwent a focused review of assay term annotations, logic and hierarchy with a goal to improve and standardize these terms. As a result, inconsistencies in W3C Web Ontology Language (OWL) expressions were identified and corrected, and additionally, standardized design patterns and a formalized template to maintain them were developed. We describe here this informative and productive process to describe the specific benefits and obstacles for OBI and the universal lessons for similar projects. Read More

View Article and Full-Text PDF

Impact of SARS-CoV-2 variants on the total CD4 and CD8 T cell reactivity in infected or vaccinated individuals.

Cell Rep Med 2021 07 2;2(7):100355. Epub 2021 Jul 2.

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the importance of addressing whether the total CD4 and CD8 T cell recognition is also affected. Here, we compare SARS-CoV-2-specific CD4 and CD8 T cells against the B.1. Read More

View Article and Full-Text PDF

Long-term follow-up of untreated Scheuermann's kyphosis.

Spine Deform 2021 11 1;9(6):1633-1639. Epub 2021 Jul 1.

The Poynton SpineCare Institute, Mater Private Dublin, Eccles St Dublin 7, Dublin, D07 WKW8, Ireland.

Study Design: Long-term cross-sectional study.

Objectives: To investigate the long-term effects of untreated Scheuermann's kyphosis on quality of life, and its relationship to radiographic parameters of spinal deformity. Previous studies reported reduced self-image, increased pain and impaired physical status. Read More

View Article and Full-Text PDF
November 2021

Relationship between Scheuermann disease and symptomatic thoracic spinal stenosis: A retrospective study.

Acta Orthop Traumatol Turc 2021 May;55(3):253-257

Department of Spine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Objective: This study aimed to investigate the possible relationship between Scheuermann disease (SD) and the pathophysiological factors of thoracic spinal stenosis (TSS), including ossification of the ligamentum flavum (OLF), ossification of the posterior longitudinal ligament (OPLL), and thoracic disc herniation (TDH) in patients with symptomatic TSS.

Methods: Demographic and radiological data from 66 consecutive patients diagnosed with symptomatic TSS from 2013 to 2018 were retrospectively collected and divided into 3 groups depending on the underlying pathomechanism of TSS: TDH group (18 patients; 6 women; mean age ± standard deviation [Sd] = 59.89 ± 11. Read More

View Article and Full-Text PDF

Lumbar Scheuermann's disease found in a patient with osteogenesis imperfecta (OI) caused by a heterozygous mutation in COL1A2 (c.4048G > A): a case report.

BMC Musculoskelet Disord 2021 Jun 7;22(1):525. Epub 2021 Jun 7.

Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, P. R. China.

Background: Osteogenesis imperfecta (OI) is a heterogeneous connective tissue disorder characterized by increased bone fragility and a series of extraskeletal manifestations. Approximately 90 % of OI cases are caused by type I collagen variants encoded by the collagen type I alpha 1 (COL1A1) or type I alpha 2 (COL1A2) gene. Lumbar Scheuermann's disease is an atypical type of Scheuermann's disease accompanied by Schmorl's nodes and irregular endplates but without pronounced kyphosis. Read More

View Article and Full-Text PDF

Dystrophin Deficiency Causes Progressive Depletion of Cardiovascular Progenitor Cells in the Heart.

Int J Mol Sci 2021 May 10;22(9). Epub 2021 May 10.

PhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.

Duchenne muscular dystrophy (DMD) is a devastating condition shortening the lifespan of young men. DMD patients suffer from age-related dilated cardiomyopathy (DCM) that leads to heart failure. Several molecular mechanisms leading to cardiomyocyte death in DMD have been described. Read More

View Article and Full-Text PDF

Polish Adaptation of the Italian Spine Youth Quality of Life Questionnaire.

J Clin Med 2021 May 12;10(10). Epub 2021 May 12.

Department of Spine Disorders and Pediatric Orthopedics, University of Medical Sciences in Poznan, 61-545 Poznan, Poland.

The study aimed to carry on the process of the cultural adaptation of the Italian Spine Youth Quality of Life Questionnaire (ISYQOL) into Polish (ISYQOL-PL). The a priori hypothesis was: the ISYQOL-PL questionnaire is reliable and appropriate for adolescents with a spinal deformity. Fifty-six adolescents (mean age 13. Read More

View Article and Full-Text PDF

SARS-CoV-2 infection of the oral cavity and saliva.

Nat Med 2021 05 25;27(5):892-903. Epub 2021 Mar 25.

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Despite signs of infection-including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema and macules-the involvement of the oral cavity in coronavirus disease 2019 (COVID-19) is poorly understood. To address this, we generated and analyzed two single-cell RNA sequencing datasets of the human minor salivary glands and gingiva (9 samples, 13,824 cells), identifying 50 cell clusters. Using integrated cell normalization and annotation, we classified 34 unique cell subpopulations between glands and gingiva. Read More

View Article and Full-Text PDF

Is It Necessary to Evaluate the Craniocervical Junction with Computed Tomoghraphy in Adolescent Spinal Deformities?

Turk Neurosurg 2021 ;31(3):441-446

University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Department of Orthopaedics and Traumatology, Istanbul, Turkey.

Aim: To assess the craniocervical junction (CCJ) by using radiological measurements in patients with adolescent idiopathic scoliosis (AIS) and Scheuermann?s kyphosis (SK), and to compare those reults with healthy adolescent population.

Material And Methods: Patients were assigned to three groups. Group 1 consisted of AIS patients, Group 2 consisted of patients with SK, and Group 3 was the control group who did not have any spinal disorder. Read More

View Article and Full-Text PDF

Hepatitis C-associated focal proliferative glomerulonephritis in an aviremic recipient of a hepatitis C-positive antibody donor liver.

Am J Transplant 2021 08 4;21(8):2895-2899. Epub 2021 May 4.

Section of Transplant Surgery, Ochsner Health, New Orleans, Louisiana.

Shortage of organs for liver transplantation (LT) and the availability of highly efficient pan-genotypic direct-acting antivirals (DAAs) against hepatitis C virus (HCV) have allowed the use of livers from HCV-positive antibody/negative nucleic acid test donors (dHCV Ab+/NAT-) into aviremic HCV recipients over the last few years. We report the case of a patient who received an LT from an HCV Ab+/NAT- donor and, after HCV viremic conversion, developed a nephrotic syndrome due to a focal proliferative glomerulonephritis early after LT. Patient's renal function and proteinuria resolved after successful treatment with DAAs. Read More

View Article and Full-Text PDF