1,514 results match your criteria Scheuermann Disease


Redox-Responsive Protein Design: Design of a Small Protein Motif Dependent on Glutathionylation.

Biochemistry 2018 Dec 4. Epub 2018 Dec 4.

Cysteine S-glutathionylation is a protein post-translational modification that promotes cellular responses to changes in oxidative conditions. The design of protein motifs that directly depend on defined changes to protein side chains provides new methods to probe diverse protein post-translational modifications. A canonical, 12-residue EF Hand motif was redesigned to be responsive to cysteine glutathionylation. Read More

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December 2018
1 Read

Effect of gastric fluid aspiration on the lung microbiota of laboratory rats.

Exp Lung Res 2018 Nov 22:1-10. Epub 2018 Nov 22.

a Department of Surgery , Duke University Medical Center , Durham , North Carolina , USA.

Aim Of The Study: The pulmonary microbiota is important for both normal homeostasis and the progression of disease, and may be affected by aspiration of gastric fluid. The aim of this study was to investigate changes in the lung microbiota induced by aspiration of gastric fluid in a laboratory rat model.

Material And Methods: Using the intratracheal application method, male rats received aspiration with 0. Read More

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November 2018
3 Reads

Early calcium handling imbalance in pressure overload-induced heart failure with nearly normal left ventricular ejection fraction.

Biochim Biophys Acta Mol Basis Dis 2019 Jan 4;1865(1):230-242. Epub 2018 Aug 4.

Université Saint Joseph, Beyrouth, Lebanon. Electronic address:

Heart failure with preserved ejection fraction (HFpEF) is a common clinical syndrome associated with high morbidity and mortality. Therapeutic options are limited due to a lack of knowledge of the pathology and its evolution. We investigated the cellular phenotype and Ca handling in hearts recapitulating HFpEF criteria. Read More

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January 2019
2 Reads

Affinity Enhancement of Protein Ligands by Reversible Covalent Modification of Neighboring Lysine Residues.

Angew Chem Int Ed Engl 2018 Nov 6. Epub 2018 Nov 6.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

The discovery of protein ligands, capable of forming a reversible covalent bond with amino acid residues on a protein target of interest, may represent a general strategy for the discovery of potent small-molecule inhibitors. We analyzed the ability of different aromatic aldehydes to form imines by reaction with lysine using H NMR techniques. 2-Hydroxybenzaldehyde derivatives were found to efficiently form imines in the millimolar concentration range. Read More

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November 2018
2 Reads

Author Correction: The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation.

Nat Commun 2018 Nov 2;9(1):4646. Epub 2018 Nov 2.

Max Planck Institute for Developmental Biology, Tübingen D-72076, Germany.

The original version of the Supplementary Information associated with this Article inadvertently omitted Supplementary Table 3. The HTML version of the Article has been updated to include a corrected version of the Supplementary Information. Read More

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November 2018
2 Reads

Quality of Life Improvement Following Surgery in Adolescent Spinal Deformity Patients: A Comparison Between Scheuermann Kyphosis and Adolescent Idiopathic Scoliosis.

Spine Deform 2018 Nov - Dec;6(6):676-683

Department of Orthopaedic Surgery, Rady Children's Hospital San Diego, 3020 Children's Way, MC 5069, San Diego, CA 92123-4282, USA.

Study Design: Preoperative and two-year follow-up health-related quality of life (HRQOL) data were prospectively collected in 82 Scheuermann kyphosis (SK) and 995 adolescent idiopathic scoliosis (AIS) patients using the Scoliosis Research Society-22 patient questionnaire (SRS-22) outcomes instrument in a multicenter study. Visual analog scale (VAS) scores were also collected for the SK population.

Objectives: This study assessed changes in HRQOL prospectively and compared them to those occurring in AIS. Read More

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January 2018
9 Reads

Contemporary Circulating Enterovirus D68 Strains Have Acquired the Capacity for Viral Entry and Replication in Human Neuronal Cells.

MBio 2018 Oct 16;9(5). Epub 2018 Oct 16.

J. Craig Venter Institute, La Jolla, California, USA

Enterovirus D68 (EV-D68) has historically been associated with respiratory illnesses. However, in the summers of 2014 and 2016, EV-D68 outbreaks coincided with a spike in polio-like acute flaccid myelitis/paralysis (AFM/AFP) cases. This raised concerns that EV-D68 could be the causative agent of AFM during these recent outbreaks. Read More

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October 2018
5 Reads

Validation of gallbladder absorbed radiation dose reduction simulation: human dosimetry of [F]fluortriopride.

EJNMMI Phys 2018 Oct 8;5(1):21. Epub 2018 Oct 8.

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Background: [F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson's disease, and schizophrenia. Preclinical radiation dosimetry studies found the gallbladder wall received the highest dose. A gallbladder dose reduction intervention was simulated using a novel reduction model for healthy adults following fatty-meal consumption. Read More

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October 2018
6 Reads

Chromosome Y-encoded antigens associate with acute graft-versus-host disease in sex-mismatched stem cell transplant.

Blood Adv 2018 Oct;2(19):2419-2429

Center for International Blood and Marrow Transplant Research, Minneapolis, MN.

Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a curative option for blood cancers, but the coupled effects of graft-versus-tumor and graft-versus-host disease (GVHD) limit its broader application. Outcomes improve with matching at HLAs, but other factors are required to explain residual risk of GVHD. In an effort to identify genetic associations outside the major histocompatibility complex, we conducted a genome-wide clinical outcomes study on 205 acute myeloid leukemia patients and their fully HLA-A-, HLA-B-, HLA-C-, HLA-DRB1-, and HLA-DQB1-matched (10/10) unrelated donors. Read More

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October 2018
3 Reads

Long term prognosis of Scheuermann's disease: The association with fragility fracture - The MINOS cohort.

Bone 2018 Dec 20;117:116-122. Epub 2018 Sep 20.

INSERM UMR 1033, University of Lyon, Lyon, France. Electronic address:

The aim was to assess the association of Scheuermann's disease (SCD) with fracture risk (vertebral, peripheral) and bone mineral density (BMD) in older men. SCD was assessed on the baseline lateral spine radiographs using the Berlin criteria in 766 men aged 50-85. We evaluated the association of SCD and its diagnostic criteria with incident fracture (vertebral over 7. Read More

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December 2018
6 Reads

Fungal resistance mediated by maize wall-associated kinase ZmWAK-RLK1 correlates with reduced benzoxazinoid content.

New Phytol 2018 Sep 4. Epub 2018 Sep 4.

Department of Plant and Microbial Biology, University of Zurich, Zollikerstrasse 107, CH-8008, Zurich, Switzerland.

Wall-associated kinases (WAKs) have recently been identified as major components of fungal and bacterial disease resistance in several cereal crop species. However, the molecular mechanisms of WAK-mediated resistance remain largely unknown. Here, we investigated the function of the maize gene ZmWAK-RLK1 (Htn1) that confers quantitative resistance to northern corn leaf blight (NCLB) caused by the hemibiotrophic fungal pathogen Exserohilum turcicum. Read More

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September 2018
2 Reads

Tensor Field Visualization using Fiber Surfaces of Invariant Space.

IEEE Trans Vis Comput Graph 2018 Aug 27. Epub 2018 Aug 27.

Scientific visualization developed successful methods for scalar and vector fields. For tensor fields, however, effective, interactive visualizations are still missing despite progress over the last decades. We present a general approach for the generation of separating surfaces in symmetric, second-order, three-dimensional tensor fields. Read More

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Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type.

Nat Neurosci 2018 Sep 27;21(9):1185-1195. Epub 2018 Aug 27.

MTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.

We describe convergent evidence from transcriptomics, morphology, and physiology for a specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA sequencing, we identify ten GABAergic interneuron subtypes with combinatorial gene signatures in human cortical layer 1 and characterize a group of human interneurons with anatomical features never described in rodents, having large 'rosehip'-like axonal boutons and compact arborization. These rosehip cells show an immunohistochemical profile (GAD1CCK, CNR1SSTCALB2PVALB) matching a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex. Read More

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September 2018
56 Reads

The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation.

Nat Commun 2018 08 20;9(1):3321. Epub 2018 Aug 20.

Max Planck Institute for Developmental Biology, Tübingen, D-72076, Germany.

FAT10 is a ubiquitin-like modifier that directly targets proteins for proteasomal degradation. Here, we report the high-resolution structures of the two individual ubiquitin-like domains (UBD) of FAT10 that are joined by a flexible linker. While the UBDs of FAT10 show the typical ubiquitin-fold, their surfaces are entirely different from each other and from ubiquitin explaining their unique binding specificities. Read More

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August 2018
2 Reads

Enhancing partner support to improve smoking cessation.

Cochrane Database Syst Rev 2018 08 13;8:CD002928. Epub 2018 Aug 13.

Department of Preventive Medicine and Public Health, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, USA, 66160.

Background: While many cessation programmes are available to assist smokers in quitting, research suggests that support from individual partners, family members, or 'buddies' may encourage abstinence.

Objectives: To determine if an intervention to enhance one-to-one partner support for smokers attempting to quit improves smoking cessation outcomes, compared with cessation interventions lacking a partner-support component.

Search Methods: We limited the search to the Cochrane Tobacco Addiction Group Specialised Register, which was updated in April 2018. Read More

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August 2018
60 Reads

Effects of canopy structure and species diversity on primary production in upper Great Lakes forests.

Oecologia 2018 Oct 4;188(2):405-415. Epub 2018 Aug 4.

Department of Biology, Virginia Commonwealth University, Box 842012, 1000 West Cary St, Richmond, VA, 23284, USA.

Canopy structure and tree species diversity, shaped by succession, disturbance, and community composition, are linked to numerous ecosystem functions, including net primary production (NPP). Understanding of how ecosystem structural metrics are interrelated and mechanistically link to NPP, however, is incomplete. We characterized leaf area index (LAI), Simpson's index of Diversity (D', a measure of species diversity), and canopy rugosity (R, a measure of canopy physical complexity) in 11 forest stands comprising two chronosequences varying in establishing disturbance, and in three late successional communities. Read More

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October 2018

Intraspinal Anomalies in Individuals with Scheuermann's Kyphosis: Is the Routine Use of Magnetic Resonance Imaging Necessary for Preoperative Evaluation?

Asian Spine J 2018 Aug 27;12(4):697-702. Epub 2018 Jul 27.

Department of Orthopaedics and Traumatology, Emsey Hospital, Istanbul, Turkey.

Study Design: Retrospective study.

Purpose: This study aimed to determine the incidence of intraspinal pathologies (ISPs) in individuals with Scheuermann's kyphosis (SK) and to validate whether the routine use of magnetic resonance imaging (MRI) is necessary for preoperative evaluation.

Overview Of Literature: There are several studies on the necessity of routine MRI screening and prevalence of ISPs related to different types of scoliosis have been conducted. Read More

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August 2018
9 Reads

Predictors of engagement in post-discharge quitline counseling among hospitalized smokers.

J Behav Med 2018 Jul 19. Epub 2018 Jul 19.

Department of Preventive Medicine and Public Health, The University of Kansas Cancer Center, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.

Quitlines provide evidence-based tobacco treatment and multiple calls yield higher quit rates. This study aimed to identify subgroups of smokers with greater quitline engagement following referral during hospitalization. Data were from a randomized clinical trial assessing the effectiveness of fax referral (referral faxed to proactive quitline) versus warm handoff (patient connected to quitline at bedside) (n = 1054). Read More

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July 2018
1 Read

Severe hyperkyphosis reduces the aerobic capacity and maximal exercise tolerance in patients with Scheuermann disease.

Spine J 2018 Jul 17. Epub 2018 Jul 17.

Department of Orthopedic Surgery, Hospital Ramón y Cajal, Ctra. de Colmenar Viejo, km. 9.100, Madrid 28034, Spain.

Background Context: The evaluation of ventilatory functional restrictions during a maximal exercise tolerance test in patients with Scheuermann disease has never been described.

Purpose: This study evaluated the respiratory functional capacity of patients with Scheuermann disease compared to healthy adolescents matched in age.

Study Design/setting: Prospective comparative study. Read More

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July 2018
8 Reads

Degradation of 4,4'-Dinitrocarbanilide in Chicken Breast by Thermal Processing.

J Agric Food Chem 2018 Aug 24;66(31):8391-8397. Epub 2018 Jul 24.

Núcleo Temático de Produção de Aves , Embrapa Suínos e Aves , Concórdia , Santa Catarina 89715-899 , Brazil.

Nicarbazin is one of the major anticoccidials used in broiler feeds. The compound 4,4'-dinitrocarbanilide (DNC) is the marker residue of concern left from nicarbazin in chicken meat. The effect of thermal processing on DNC content accumulated in chicken breast was assessed, and samples were analyzed by liquid chromatography-tandem mass spectrometry. Read More

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August 2018
22 Reads

Ultrasound Promoted Step-Growth Polymerization and Polymer Crosslinking Via Copper Catalyzed Azide-Alkyne "Click" Reaction.

Angew Chem Int Ed Engl 2018 Aug 27;57(35):11208-11212. Epub 2018 Jul 27.

Institute for Molecular Engineering, University of Chicago, 5640 South Ellis Avenue, Chicago, IL, 60637, USA.

Mechano-activated chemistry is a powerful tool for remodeling of synthetic polymeric materials, however, few reactions are currently available. Here we show that using piezochemical reduction of a Cu -based pre-catalyst, a step-growth polymerization occurs via the copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction to form a linear polytriazole. Furthermore, we show that a linear polymer can be crosslinked mechanochemically using the same chemistry to form a solid organogel. Read More

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August 2018
11.261 Impact Factor

Improvement in Liver Transplant Outcomes From Older Donors: A US National Analysis.

Ann Surg 2018 Jun 28. Epub 2018 Jun 28.

Department of Surgery, Duke University Medical Center, Durham, NC.

Objective: To investigate trends in long-term graft and patient outcomes following liver transplantation using grafts from donors ≥60 years old.

Summary Background Data: The scarcity of donor livers has led to increased utilization of organs from donors ≥60 years old. However, few studies have examined how long-term transplant outcomes from older donors have evolved over time. Read More

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June 2018
1 Read

Adaptation of the Scoliosis Research Society-22 Questionnaire for the Hebrew Language: Transcultural Adaptation and Reliability Analysis.

Spine Deform 2018 Jul - Aug;6(4):397-402

Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences at Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address:

Study Design: A cross-cultural adaptation and reliability study.

Objective: To perform cross-cultural adaptation and evaluate the reliability and validity of the Hebrew version of the Scoliosis Research Society-22 (SRS-22) questionnaire.

Summary Of Background Data: The SRS-22 validated in different languages is used in assessing health-related quality of life of patients with scoliosis. Read More

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August 2017
2 Reads

VDJServer: A Cloud-Based Analysis Portal and Data Commons for Immune Repertoire Sequences and Rearrangements.

Front Immunol 2018 8;9:976. Epub 2018 May 8.

Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Background: Recent technological advances in immune repertoire sequencing have created tremendous potential for advancing our understanding of adaptive immune response dynamics in various states of health and disease. Immune repertoire sequencing produces large, highly complex data sets, however, which require specialized methods and software tools for their effective analysis and interpretation.

Results: VDJServer is a cloud-based analysis portal for immune repertoire sequence data that provide access to a suite of tools for a complete analysis workflow, including modules for preprocessing and quality control of sequence reads, V(D)J gene segment assignment, repertoire characterization, and repertoire comparison. Read More

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May 2018
4 Reads

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.

ChemMedChem 2018 Jul 1;13(13):1303-1307. Epub 2018 Jun 1.

Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.

A DNA-encoded chemical library (DECL) with 1.2 million compounds was synthesized by combinatorial reaction of seven central scaffolds with two sets of 343×492 building blocks. Library screening by affinity capture revealed that for some target proteins, the chemical nature of building blocks dominated the selection results, whereas for other proteins, the central scaffold also crucially contributed to ligand affinity. Read More

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July 2018
1 Read

Posterior-only versus combined anterior/posterior fusion in Scheuermann disease: a large retrospective study.

Eur Spine J 2018 Sep 19;27(9):2322-2330. Epub 2018 May 19.

Groupe Hospitalier Paris Saint-Joseph, 185, rue Raymond Losserand, 75014, Paris, France.

Purpose: The literature shows controversies concerning surgical treatment of Scheuermann's kyphosis between posterior-only fixation and combined anterior/posterior fusion. The aim of this study is to compare the clinical and radiological results and the rate of complications between these two techniques.

Methods: We performed a multicentric retrospective review of 131 patients who underwent primary fusion for Scheuermann's kyphosis divided into two groups: 67 patients operated via posterior approach only and 64 operated via combined anterior/posterior approach. Read More

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September 2018
5 Reads

Bioinformatics Meets Virology: The European Virus Bioinformatics Center's Second Annual Meeting.

Viruses 2018 May 14;10(5). Epub 2018 May 14.

European Virus Bioinformatics Center, 07743 Jena, Germany.

The Second Annual Meeting of the European Virus Bioinformatics Center (EVBC), held in Utrecht, Netherlands, focused on computational approaches in virology, with topics including (but not limited to) virus discovery, diagnostics, (meta-)genomics, modeling, epidemiology, molecular structure, evolution, and viral ecology. The goals of the Second Annual Meeting were threefold: (i) to bring together virologists and bioinformaticians from across the academic, industrial, professional, and training sectors to share best practice; (ii) to provide a meaningful and interactive scientific environment to promote discussion and collaboration between students, postdoctoral fellows, and both new and established investigators; (iii) to inspire and suggest new research directions and questions. Approximately 120 researchers from around the world attended the Second Annual Meeting of the EVBC this year, including 15 renowned international speakers. Read More

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May 2018
4 Reads

Scheuermann's Disease with Extensive Involvement of Dorsolumbar Spine.

Indian J Pediatr 2018 09 3;85(9):818-819. Epub 2018 May 3.

Department of Pediatrics, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi, 110 095, India.

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September 2018
1 Read

Daily and Nondaily Smoking Varies by Acculturation among English-Speaking, US Latino Men and Women.

Ethn Dis 2018 26;28(2):105-114. Epub 2018 Apr 26.

Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI.

Background: Higher smoking prevalence and quantity (cigarettes per day) has been linked to acculturation in the United States among Latinas, but not Latino men. Our study examines variation between a different and increasingly important target behavior, smoking level (nondaily vs daily) and acculturation by sex.

Methods: An online English-language survey was administered to 786 Latino smokers during July through August 2012. Read More

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Predominance Tag Maps.

IEEE Trans Vis Comput Graph 2018 Jun;24(6):1893-1904

A predominance map expresses the predominant data category for each geographical entity and colors are used to differentiate a small number of data categories. In tag maps, many data categories are present in the form of different tags, but related tag map approaches do not account for predominance, as tags are either displaced from their respective geographical locations or visual clutter occurs. We propose predominance tag maps, a layout algorithm that accounts for predominance for arbitrary aggregation granularities. Read More

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DNA-encoded chemical libraries - achievements and remaining challenges.

FEBS Lett 2018 Jun 10;592(12):2168-2180. Epub 2018 May 10.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.

DNA-encoded chemical libraries (DECLs) are collections of compounds, individually coupled to DNA tags serving as amplifiable identification barcodes. Since individual compounds can be identified by the associated DNA tag, they can be stored as a mixture, allowing the synthesis and screening of combinatorial libraries of unprecedented size, facilitated by the implementation of split-and-pool synthetic procedures or other experimental methodologies. In this review, we briefly present relevant concepts and technologies, which are required for the implementation and interpretation of screening procedures with DNA-encoded chemical libraries. Read More

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June 2018
9 Reads

DAFi: A directed recursive data filtering and clustering approach for improving and interpreting data clustering identification of cell populations from polychromatic flow cytometry data.

Cytometry A 2018 Jun 17;93(6):597-610. Epub 2018 Apr 17.

J. Craig Venter Institute, La Jolla, California.

Computational methods for identification of cell populations from polychromatic flow cytometry data are changing the paradigm of cytometry bioinformatics. Data clustering is the most common computational approach to unsupervised identification of cell populations from multidimensional cytometry data. However, interpretation of the identified data clusters is labor-intensive. Read More

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June 2018
4 Reads

Cell type discovery using single-cell transcriptomics: implications for ontological representation.

Hum Mol Genet 2018 May;27(R1):R40-R47

J. Craig Venter Institute, La Jolla, CA 92037, USA.

Cells are fundamental function units of multicellular organisms, with different cell types playing distinct physiological roles in the body. The recent advent of single-cell transcriptional profiling using RNA sequencing is producing 'big data', enabling the identification of novel human cell types at an unprecedented rate. In this review, we summarize recent work characterizing cell types in the human central nervous and immune systems using single-cell and single-nuclei RNA sequencing, and discuss the implications that these discoveries are having on the representation of cell types in the reference Cell Ontology (CL). Read More

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May 2018
10 Reads

Is the inclinometer a valid measure of thoracic kyphosis? A cross-sectional study.

Braz J Phys Ther 2018 Jul - Aug;22(4):310-317. Epub 2018 Mar 6.

The University of Newcastle, School of Health Sciences, Discipline of Physiotherapy, Callaghan, NSW, Australia.

Background: Radiographs are used to monitor thoracic kyphosis in individuals with certain pathologies (e.g. osteoporosis), exposing patients to potentially harmful radiation. Read More

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March 2018
2 Reads

Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold.

Nat Chem 2018 Apr 19;10(4):441-448. Epub 2018 Mar 19.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.

In nature, specific antibodies can be generated as a result of an adaptive selection and expansion of lymphocytes with suitable protein binding properties. We attempted to mimic antibody-antigen recognition by displaying multiple chemical diversity elements on a defined macrocyclic scaffold. Encoding of the displayed combinations was achieved using distinctive DNA tags, resulting in a library size of 35,393,112. Read More

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April 2018
6 Reads

An Evaluation of SmokeFree for Kansas Kids: An Intervention to Promote Tobacco Cessation in Pediatric Clinics.

Kans J Med 2017 Feb 15;10(1):7-11. Epub 2017 Feb 15.

Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, KS.

Introduction: Smokefree for Kansas Kids is a program designed to train pediatric clinic staff to assess for tobacco exposure and provide brief smoking cessation interventions to caregivers and patients. The purpose of this study was to evaluate the impact of this program and improve future tobacco intervention efforts in pediatric clinics.

Method: Eighty-six pediatric physicians and staff attended at least one of three training sessions. Read More

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February 2017

Reciprocal Changes in Sagittal Alignment With Operative Treatment of Adolescent Scheuermann Kyphosis-Prospective Evaluation of 96 Patients.

Spine Deform 2018 Mar - Apr;6(2):177-184

Rady Children's Hospital San Diego, 3020 Children's Way, San Diego, CA 92123, USA.

Introduction: Sagittal alignment abnormalities in Scheuermann kyphosis (SK) strongly correlate with quality of life measures. The changes in spinopelvic parameters after posterior spinal fusion have not been adequately studied. This study is to evaluate the reciprocal changes in spinopelvic parameters following surgical correction for SK. Read More

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August 2016
2 Reads

Effects of Lumacaftor-Ivacaftor Therapy on Cystic Fibrosis Transmembrane Conductance Regulator Function in Phe508del Homozygous Patients with Cystic Fibrosis.

Am J Respir Crit Care Med 2018 Jun;197(11):1433-1442

5 Clinic of Pediatric Pneumology, Allergology, and Neonatology and.

Rationale: The combination of the CFTR (cystic fibrosis transmembrane conductance regulator) corrector lumacaftor with the potentiator ivacaftor has been approved for the treatment of patients with cystic fibrosis homozygous for the Phe508del CFTR mutation. The phase 3 trials examined clinical outcomes but did not evaluate CFTR function in patients.

Objectives: To examine the effect of lumacaftor-ivacaftor on biomarkers of CFTR function in Phe508del homozygous patients with cystic fibrosis aged 12 years and older. Read More

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June 2018
15 Reads

Cell type discovery and representation in the era of high-content single cell phenotyping.

BMC Bioinformatics 2017 12 21;18(Suppl 17):559. Epub 2017 Dec 21.

J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA, 92037, USA.

Background: A fundamental characteristic of multicellular organisms is the specialization of functional cell types through the process of differentiation. These specialized cell types not only characterize the normal functioning of different organs and tissues, they can also be used as cellular biomarkers of a variety of different disease states and therapeutic/vaccine responses. In order to serve as a reference for cell type representation, the Cell Ontology has been developed to provide a standard nomenclature of defined cell types for comparative analysis and biomarker discovery. Read More

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December 2017
8 Reads

Measuring temporal stability of positron emission tomography standardized uptake value bias using long-lived sources in a multicenter network.

J Med Imaging (Bellingham) 2018 Jan 4;5(1):011016. Epub 2018 Jan 4.

University of Washington, Department of Radiology, Seattle, Washington, United States.

Positron emission tomography (PET) is a quantitative imaging modality, but the computation of standardized uptake values (SUVs) requires several instruments to be correctly calibrated. Variability in the calibration process may lead to unreliable quantitation. Sealed source kits containing traceable amounts of [Formula: see text] were used to measure signal stability for 19 PET scanners at nine hospitals in the National Cancer Institute's Quantitative Imaging Network. Read More

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January 2018
10 Reads

Selection of distal fusion level in terms of distal junctional kyphosis in Scheuermann kyphosis. A comparison of 3 methods.

Acta Orthop Traumatol Turc 2018 Jan 28;52(1):7-11. Epub 2017 Dec 28.

Acibadem University Atakent Hospital, Department of Orthopaedics and Traumatology, Istanbul, Turkey.

Objective: The aim of this study was to investigate the effect of distal fusion level selection on the distal junctional kyphosis (DJK) in Scheuermann kyphosis (SK) patients who underwent posterior fusion.

Methods: Thirty-nine SK patients who underwent posterior fusion with a minimum follow-up of 3 years were retrospectively evaluated. According to the distal fusion level, patients were divided into 3 groups. Read More

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January 2018
24 Reads

Altered myofilament structure and function in dogs with Duchenne muscular dystrophy cardiomyopathy.

J Mol Cell Cardiol 2018 Jan 22;114:345-353. Epub 2017 Dec 22.

INSERM U1046, CNRS UMR 9214, Université de Montpellier, Physiologie et Médecine Expérimentale du cœur et des muscles - PHYMEDEXP, CHU Arnaud de Villeneuve, 34295 Montpellier cedex 05, France.. Electronic address:

Aim: Duchenne Muscular Dystrophy (DMD) is associated with progressive depressed left ventricular (LV) function. However, DMD effects on myofilament structure and function are poorly understood. Golden Retriever Muscular Dystrophy (GRMD) is a dog model of DMD recapitulating the human form of DMD. Read More

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January 2018
7 Reads
4.660 Impact Factor

Murine model of oropharyngeal gastric fluid aspiration-A new assessment method for intrapulmonary liquid distribution using digital pixel calculation.

Exp Lung Res 2017 Nov - Dec;43(9-10):434-438

a Department of Surgery , Duke University Medical Center , Durham , North Carolina , USA.

Aim Of The Study: The aim of this study was to investigate a new method for visualization and quantification of intrapulmonary liquid distribution after oropharyngeal gastric fluid aspiration in mice.

Material And Methods: Eleven mice received oropharyngeal aspiration with a gastric fluid, India ink, and saline solution. Digital imaging and pixel calculation were used to analyze intrapulmonary fluid distribution selectively. Read More

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August 2018
12 Reads

Hybrid nanofibers based on poly-caprolactone/gelatin/hydroxyapatite nanoparticles-loaded Doxycycline: Effective anti-tumoral and antibacterial activity.

Mater Sci Eng C Mater Biol Appl 2018 Feb 3;83:25-34. Epub 2017 Aug 3.

Chemistry Depatment, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, Belo Horizonte, MG CEP 31270-901, Brazil. Electronic address:

Cancer is one of the leading causes of morbidity and mortality Worldwide, 19.3 million new cancer cases are expected to be identified in 2025. Among the therapeutic arsenal to cancer control one could find the Doxycycline and the nano hydroxyapatite. Read More

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February 2018
18 Reads

Adding Satellite Rods to Standard Two-rod Construct With the Use of Duet Screws: An Effective Technique to Improve Surgical Outcomes and Preventing Proximal Junctional Kyphosis in Posterior-Only Correction of Scheuermann Kyphosis.

Spine (Phila Pa 1976) 2018 07;43(13):E758-E765

Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Study Design: A retrospective matched-cohort comparative study.

Objective: The aim of this study was to compare the surgical results after the use of duet screw based satellite rods and bilateral satellite rods (S-RC) versus a standard two-rod construct (2-RC) across osteotomy sites in a matched cohort with Scheuermann kyphosis (SK).

Summary Of Background Data: Multiple Ponte osteotomies are frequently employed to correct SK via a posterior-only approach, with a 2-RC across the osteotomy sites. Read More

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July 2018
3 Reads

Toward Scintillator High-Gain Avalanche Rushing Photoconductor Active Matrix Flat Panel Imager (SHARP-AMFPI): Initial fabrication and characterization.

Med Phys 2018 Feb 18;45(2):794-802. Epub 2017 Dec 18.

Department of Radiology, Stony Brook University, Stony Brook, NY, 11794, USA.

Purpose: We present the first prototype Scintillator High-Gain Avalanche Rushing Photoconductor Active Matrix Flat Panel Imager (SHARP-AMFPI). This detector includes a layer of avalanche amorphous Selenium (a-Se) (HARP) as the photoconductor in an indirect detector to amplify the signal and reduce the effects of electronic noise to obtain quantum noise-limited images for low-dose applications. It is the first time avalanche a-Se has been used in a solid-state imaging device and poses as a possible solution to eliminate the effects of electronic noise, which is crucial for low-dose imaging performance of AMFPI. Read More

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February 2018
10 Reads

Severe rigid Scheuermann kyphosis in adult patients; correction with posterior-only approach.

Musculoskelet Surg 2018 Dec 17;102(3):257-260. Epub 2017 Nov 17.

Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Scheuermann kyphosis is the most common structural kyphosis among adolescence and young people. Surgical treatment may be performed through combined anterior and posterior or posterior-only approaches; to our knowledge, the efficacy of posterior-only approach as less invasive procedure is not well studied in case of severe rigid Scheuermann kyphosis.

Materials And Methods: Eighteen patients with severe rigid Scheuermann kyphosis operated through only posterior approach from 2013 to 2016 were evaluated. Read More

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December 2018
2 Reads

Automated Analysis of Clinical Flow Cytometry Data: A Chronic Lymphocytic Leukemia Illustration.

Clin Lab Med 2017 12;37(4):931-944

Department of Informatics, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037, USA.

Flow cytometry is used in cell-based diagnostic evaluation for blood-borne malignancies including leukemia and lymphoma. The current practice for cytometry data analysis relies on manual gating to identify cell subsets in complex mixtures, which is subjective, labor-intensive, and poorly reproducible. This article reviews recent efforts to develop, validate, and disseminate automated computational methods and pipelines for cytometry data analysis that could help overcome the limitations of manual analysis and provide for efficient and data-driven diagnostic applications. Read More

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December 2017
11 Reads