Search Our Scientific Publications & Authors

Eur Spine J 2020 May 18. Epub 2020 May 18.

Spine Unit, Department of Orthopedic Surgery, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Purpose: To investigate the impact of Scheuermann's Kyphosis (SK) on health -related quality of life (HRQOL) in adult patients and compare it to the general population. Moreover, to assess whether location of the kyphosis affects pelvic parameters, HRQOL, and pulmonary function.

Methods: Of a cohort of 251 patients seen for a pediatric spinal deformity in the years 1972-1982 in our outpatient clinic, 55 had radiologically verified SK. Read More

Am J Respir Crit Care Med 2020 May 18. Epub 2020 May 18.

Friedrich-Loeffler-Institute Federal Research Institute for Animal Health, 39023, Greifswald - Insel Riems, Germany;

Rationale: Platelets are generated in the capillaries of the lung, control hemostasis and display immunological functions. Tuberculosis primarily affects the lung and patients show platelet changes and hemoptysis. A role of platelets in immunopathology of pulmonary tuberculosis requires careful assessment. Read More

Proc Natl Acad Sci U S A 2020 May 7. Epub 2020 May 7.

Emerging Pathogens Institute, University of Florida, Gainesville, FL 32609;

Cell Host Microbe 2020 04 16;27(4):671-680.e2. Epub 2020 Mar 16.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA. Electronic address:

Effective countermeasures against the recent emergence and rapid expansion of the 2019 novel coronavirus (SARS-CoV-2) require the development of data and tools to understand and monitor its spread and immune responses to it. However, little information is available about the targets of immune responses to SARS-CoV-2. We used the Immune Epitope Database and Analysis Resource (IEDB) to catalog available data related to other coronaviruses. Read More

J Orthop 2020 Sep-Oct;21:69-74. Epub 2020 Feb 4.

Research Institute Orton, Helsinki, Finland, Tenholantie 10, PL 29, 00281, Helsinki, Finland.

Background: There are only a few studies on untreated Scheuermann's disease and magnetic resonance imaging (MRI) findings in the lumbar spine. The primary aim of this study was to clarify lumbar MRI findings in patients with Scheuermann's disease and to compare with subjects without diagnosed spine disease.

Methods: Twenty-two male adult Scheuermann's patients (mean age 64. Read More

Int J Spine Surg 2019 Dec 31;13(6):536-543. Epub 2019 Dec 31.

Neurochirurgie Fathi AG, Schachen 22, 5000 Aarau, Switzerland.

Background: Sagittal spinopelvic parameters remain poorly defined in patients with Scheuermann disease (SD). For example, although pelvic incidence (PI) should approximate lumbar lordosis (LL) by 10°, this is not true in patients with SD. This retrospective radiographic study was conducted to propose a new mathematical relationship between sagittal spinopelvic parameters in skeletally mature patients with SD. Read More

BMC Nephrol 2019 12 9;20(1):453. Epub 2019 Dec 9.

Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany.

Background: The effects of Simultaneous Pancreas Kidney Transplantation (SPKT) on Peripheral Vascular Disease (PVD) warrants additional study and more target focus, since little is known about the mid- and long-term effects on the progression of PVD after transplantation.

Methods: 101 SPKT and 26 Kidney Transplantation Alone (KTA) recipients with insulin-dependent diabetes mellitus (IDDM) were retrospectively evaluated with regard to graft and metabolic outcome. Special subgroup analysis was directed towards the development and progression of peripheral vascular complications (PVC) (amputation, ischemic ulceration, lower extremity angioplasty/ bypass surgery) after transplantation. Read More

Pediatr Clin North Am 2020 02;67(1):185-204

Spine Surgery, Institute for Spine and Scoliosis, Lawrenceville, NJ, USA; Orthopedics, Mount Sinai Hospital, New York, NY, USA; Orthopedics, St Peters University Hospital, New Brunswick, NJ, USA. Electronic address:

Pediatric spine disorders are numerous and are quite different when compared with the adult population. This article focuses on some of the more common pediatric spine disorders. This article summarizes such disorders and discusses typical treatment options in the pediatric orthopedic armamentarium. Read More

J Neurosurg Spine 2019 Nov;32(2):235-247

Objective: Scheuermann kyphosis (SK) is an idiopathic kyphosis characterized by anterior wedging of ≥ 5° at 3 contiguous vertebrae managed with either nonoperative or operative treatment. Nonoperative treatment typically employs bracing, while operative treatment is performed with either a combined anterior-posterior fusion or posterior-only approach. Current evidence for these approaches has largely been derived from retrospective case series or focused reviews. Read More

Hum Immunol 2019 Nov 23;80(11):923-929. Epub 2019 Aug 23.

Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California, San Diego, CA 92093, USA.

Enteroviruses are potentially linked to the emergence of Acute Flaccid Myelitis (AFM), a rare but very serious condition that affects the nervous system. AFM has been associated with coxsackievirus A16, enterovirus A71 (EVA71) and enterovirus D68 (EVD68). Little is known about host-pathogen interactions for these viruses, and whether immune responses may have a protective or immunopathological role in disease presentations. Read More

Nature 2019 09 21;573(7772):61-68. Epub 2019 Aug 21.

Allen Institute for Brain Science, Seattle, WA, USA.

Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-sequencing analysis to perform a comprehensive study of cell types in the middle temporal gyrus of human cortex. We identified a highly diverse set of excitatory and inhibitory neuron types that are mostly sparse, with excitatory types being less layer-restricted than expected. Read More

JCI Insight 2019 Aug 22;4(16). Epub 2019 Aug 22.

Department of Surgery and.

Multiple organ failure (MOF) is the leading cause of late mortality and morbidity in patients who are admitted to intensive care units (ICUs). However, there is an epidemiologic discrepancy in the mechanism of underlying immunologic derangement dependent on etiology between sepsis and trauma patients in MOF. We hypothesized that damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs), while both involved in the development of MOF, contribute differently to the systemic innate immune derangement and coagulopathic changes. Read More

Spine J 2019 09 12;19(9):1529-1539. Epub 2019 Apr 12.

Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. Electronic address:

Background Context: The surgical strategy to decide distal fusion level for Scheuermann kyphosis (SK) is controversial. Some spinal surgeons advocate that instrumentation should end at the first lordotic vertebra (FLV), whereas others recommend extending spinal fusion to the sagittal stable vertebra (SSV). Scheuermann kyphosis has two curve patterns: Scheuermann thoracic kyphosis (STK), with the curve apex above or at T10; and Scheuermann thoracolumbar kyphosis (STLK), with the curve apex below T10. Read More

J Pediatr Orthop 2019 May/Jun;39(5):217-221

Mayo Clinic, Rochester, MN.

Background: Surgical indications for Scheuermann kyphosis are variable. We sought to evaluate the characteristics of patients undergoing operative versus nonoperative treatment of Scheuermann kyphosis to better understand current practices and the factors which contribute to the decision for surgical management.

Methods: Multicenter prospective cohort study. Read More

Clin Spine Surg 2019 10;32(8):330-336

Department of Orthopedics, Peking University Third Hospital, Haidian District.

Study Design: This study was a systematic review and meta-analysis.

Objectives: To compare stable sagittal vertebra (SSV) and first lordotic vertebra (FLV) instrumentation for prevention of distal junctional kyphosis (DJK) in Scheuermann disease.

Summary Of Background Data: The SSV has been increasingly chosen as the lowest instrumented vertebra to prevent DJK, and some studies have provided supportive results. Read More

Liver Transpl 2019 04 15;25(4):610-626. Epub 2019 Mar 15.

Department of Surgery, Duke University Medical Center, Durham, NC.

Machine preservation (MP) has emerged as a promising technology in liver transplantation, but the cellular processes occurring during MP have not been characterized. Recent studies have noted the presence of inflammatory molecules generated during MP. We hypothesized that there is a metabolism-dependent accumulation of damage-associated molecular patterns (DAMPs) and inflammatory cytokines during MP and that these molecules provoke inflammation in the graft. Read More

J Orthop Sci 2019 Sep 23;24(5):776-779. Epub 2019 Jan 23.

Department of Orthopaedic Surgery, School of Medicine, Pontificia, Universidad Catolica de Chile, Chile.

Background: There is insufficient knowledge of the epidemiology of Scheuermann's disease. The data available comes from estimations from young adults with obvious deformity, from studies evaluating children who may not have developed the deformity yet, or from older populations who can develop vertebral wedging secondary to other causes. We aimed to determine the prevalence of Scheuermann's disease in patients 15-40 years old using plain chest radiographs as a screening tool. Read More

Asian Spine J 2019 Jun 24;13(3):490-499. Epub 2019 Jan 24.

Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences at Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Study Design: Randomized controlled single-blinded clinical trial.

Purpose: To evaluate the efficacy of Schroth therapy on thoracic curve angle, pain, and self-perceived body image (SPBI) of the back in Scheuermann's patients in comparison with the efficacy of classic anti-gravitation exercises.

Overview Of Literature: Scheuermann disease is the most common cause of hyperkyphosis of the thoracic and thoracolumbar spine during adolescence. Read More

Spine Deform 2019 03;7(2):245-253

Department of Pediatric Orthopaedics, Robert Debré Hospital, AP-HP, Paris Diderot University, 48 Bd Sérurier, 75019 Paris, France.

Study Design: Retrospective monocentric database study.

Objectives: To describe the "frame" reduction technique and report the 3D quantitative analysis of postoperative corrections in a consecutive series of thoracic adolescent idiopathic scoliosis (AIS) patients.

Summary Of Background Data: Posteromedial translation technique using sublaminar bands have been proved to be efficient and safe for 3D correction of the deformity and overall cosmetic aspect of the trunk. Read More

Spine Deform 2019 03;7(2):236-244

Bordeaux University Hospital, Department of Spinal Surgery, Unit 1, C.H.U Tripode Pellegrin, Place Amélie Raba Léon, 33076 Bordeaux, France.

Study Design: Case-control study.

Objectives: To analyse global sagittal alignment including the cranial center of mass (CCOM) and proximal junctional kyphosis (PJK) in adolescent idiopathic scoliosis (AIS) patients treated with posterior instrumentation.

Summary Of Background Data: PJK plays an important role in the global sagittal alignment in AIS patients. Read More

J Back Musculoskelet Rehabil 2019 ;32(4):639-646

Department of Orthopaedic Surgery, Shafa Yahyaiian Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background: Exercises are usually prescribed in association with orthotic intervention for management of idiopathic scoliosis, however the role of these exercises on the efficacy of brace and/or balance is not clear yet.

Objectives: To investigate the role of exercise (the Blount and Moe protocol) on static balance and Cobb angle changes in adolescents with spinal deformities during weaning from brace.

Methods: Seventeen brace users were allocated into 3 groups (good, moderate, and weak), according to their exercise quality and quantity static balance was evaluated on 4 conditions (standing on a platform/foam; with/without brace) using a force platform. Read More

J Back Musculoskelet Rehabil 2019 ;32(4):647-654

Department of Orthopaedic Surgery, Shafa Yahyaiian hospital, Iran University of Medical Sciences, Tehran, Iran.

Background: There is a lack of evidence in reliability of the modified sphygmomanometer to measure the brace-interface pad pressure in adolescents with Scheuermann's kyphosis (SK).

Objectives: To evaluate the intra- and inter-observer reliability of modified sphygmomanometer for measuring interface pad pressure in the Milwaukee brace.

Methods: Two observers measured the pressure of the shoulder and kyphosis pads in Milwaukee brace on 33 adolescents with SK with an average age of 14. Read More

Spine Deform 2019 01;7(1):100-106

Department of Orthopaedics, NYU Langone Orthopedic Hospital, 301 East 17th St, New York, NY 10003, USA. Electronic address:

Study Design: Retrospective review of KID Inpatient Database (KID) from 2003, 2006, 2009, and 2012.

Objectives: The aim of this study was to evaluate the impact of advances in spinal surgery on patient outcomes in the treatment of Scheuermann kyphosis (SK).

Summary Of Background Data: SK is one of the most common causes of back pain in adolescents. Read More

Exp Lung Res 2018 May - Jun;44(4-5):201-210. Epub 2018 Nov 22.

a Department of Surgery , Duke University Medical Center , Durham , North Carolina , USA.

Aim Of The Study: The pulmonary microbiota is important for both normal homeostasis and the progression of disease, and may be affected by aspiration of gastric fluid. The aim of this study was to investigate changes in the lung microbiota induced by aspiration of gastric fluid in a laboratory rat model.

Material And Methods: Using the intratracheal application method, male rats received aspiration with 0. Read More

Biochim Biophys Acta Mol Basis Dis 2019 01 4;1865(1):230-242. Epub 2018 Aug 4.

Université Saint Joseph, Beyrouth, Lebanon. Electronic address:

Heart failure with preserved ejection fraction (HFpEF) is a common clinical syndrome associated with high morbidity and mortality. Therapeutic options are limited due to a lack of knowledge of the pathology and its evolution. We investigated the cellular phenotype and Ca handling in hearts recapitulating HFpEF criteria. Read More

J Am Acad Orthop Surg 2019 May;27(10):e462-e472

From the Department of Orthopedic Surgery, Columbia University College of Physicians and Surgeons, New York, NY (Dr. Sardar and Dr. Lenke), and the Department of Orthopaedic Surgery and Sports Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (Dr. Ames).

Scheuermann's kyphosis (SK) is a rigid structural deformity of the thoracic spine defined radiographically as three or more contiguous vertebrae with at least 5° of wedging anteriorly. Prevalence of the disease is thought to be between 0.4% and 10%. Read More

Spine Deform 2018 Nov - Dec;6(6):676-683

Department of Orthopaedic Surgery, Rady Children's Hospital San Diego, 3020 Children's Way, MC 5069, San Diego, CA 92123-4282, USA.

Study Design: Preoperative and two-year follow-up health-related quality of life (HRQOL) data were prospectively collected in 82 Scheuermann kyphosis (SK) and 995 adolescent idiopathic scoliosis (AIS) patients using the Scoliosis Research Society-22 patient questionnaire (SRS-22) outcomes instrument in a multicenter study. Visual analog scale (VAS) scores were also collected for the SK population.

Objectives: This study assessed changes in HRQOL prospectively and compared them to those occurring in AIS. Read More

EJNMMI Phys 2018 Oct 8;5(1):21. Epub 2018 Oct 8.

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Background: [F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson's disease, and schizophrenia. Preclinical radiation dosimetry studies found the gallbladder wall received the highest dose. A gallbladder dose reduction intervention was simulated using a novel reduction model for healthy adults following fatty-meal consumption. Read More

Blood Adv 2018 10;2(19):2419-2429

Center for International Blood and Marrow Transplant Research, Minneapolis, MN.

Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a curative option for blood cancers, but the coupled effects of graft-versus-tumor and graft-versus-host disease (GVHD) limit its broader application. Outcomes improve with matching at HLAs, but other factors are required to explain residual risk of GVHD. In an effort to identify genetic associations outside the major histocompatibility complex, we conducted a genome-wide clinical outcomes study on 205 acute myeloid leukemia patients and their fully HLA-A-, HLA-B-, HLA-C-, HLA-DRB1-, and HLA-DQB1-matched (10/10) unrelated donors. Read More

Bone 2018 12 20;117:116-122. Epub 2018 Sep 20.

INSERM UMR 1033, University of Lyon, Lyon, France. Electronic address:

The aim was to assess the association of Scheuermann's disease (SCD) with fracture risk (vertebral, peripheral) and bone mineral density (BMD) in older men. SCD was assessed on the baseline lateral spine radiographs using the Berlin criteria in 766 men aged 50-85. We evaluated the association of SCD and its diagnostic criteria with incident fracture (vertebral over 7. Read More

New Phytol 2019 01 4;221(2):976-987. Epub 2018 Sep 4.

Department of Plant and Microbial Biology, University of Zurich, Zollikerstrasse 107, CH-8008, Zurich, Switzerland.

Wall-associated kinases (WAKs) have recently been identified as major components of fungal and bacterial disease resistance in several cereal crop species. However, the molecular mechanisms of WAK-mediated resistance remain largely unknown. Here, we investigated the function of the maize gene ZmWAK-RLK1 (Htn1) that confers quantitative resistance to northern corn leaf blight (NCLB) caused by the hemibiotrophic fungal pathogen Exserohilum turcicum. Read More

Asian Spine J 2018 Aug 27;12(4):697-702. Epub 2018 Jul 27.

Department of Orthopaedics and Traumatology, Emsey Hospital, Istanbul, Turkey.

Study Design: Retrospective study.

Purpose: This study aimed to determine the incidence of intraspinal pathologies (ISPs) in individuals with Scheuermann's kyphosis (SK) and to validate whether the routine use of magnetic resonance imaging (MRI) is necessary for preoperative evaluation.

Overview Of Literature: There are several studies on the necessity of routine MRI screening and prevalence of ISPs related to different types of scoliosis have been conducted. Read More

Spine J 2019 02 17;19(2):330-338. Epub 2018 Jul 17.

Department of Orthopedic Surgery, Hospital Ramón y Cajal, Ctra. de Colmenar Viejo, km. 9.100, Madrid 28034, Spain.

Background Context: The evaluation of ventilatory functional restrictions during a maximal exercise tolerance test in patients with Scheuermann disease has never been described.

Purpose: This study evaluated the respiratory functional capacity of patients with Scheuermann disease compared to healthy adolescents matched in age.

Study Design/setting: Prospective comparative study. Read More

Spine Deform 2018 Jul - Aug;6(4):397-402

Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences at Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address:

Study Design: A cross-cultural adaptation and reliability study.

Objective: To perform cross-cultural adaptation and evaluate the reliability and validity of the Hebrew version of the Scoliosis Research Society-22 (SRS-22) questionnaire.

Summary Of Background Data: The SRS-22 validated in different languages is used in assessing health-related quality of life of patients with scoliosis. Read More

Front Immunol 2018 8;9:976. Epub 2018 May 8.

Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Background: Recent technological advances in immune repertoire sequencing have created tremendous potential for advancing our understanding of adaptive immune response dynamics in various states of health and disease. Immune repertoire sequencing produces large, highly complex data sets, however, which require specialized methods and software tools for their effective analysis and interpretation.

Results: VDJServer is a cloud-based analysis portal for immune repertoire sequence data that provide access to a suite of tools for a complete analysis workflow, including modules for preprocessing and quality control of sequence reads, V(D)J gene segment assignment, repertoire characterization, and repertoire comparison. Read More

Eur Spine J 2018 09 19;27(9):2322-2330. Epub 2018 May 19.

Groupe Hospitalier Paris Saint-Joseph, 185, rue Raymond Losserand, 75014, Paris, France.

Purpose: The literature shows controversies concerning surgical treatment of Scheuermann's kyphosis between posterior-only fixation and combined anterior/posterior fusion. The aim of this study is to compare the clinical and radiological results and the rate of complications between these two techniques.

Methods: We performed a multicentric retrospective review of 131 patients who underwent primary fusion for Scheuermann's kyphosis divided into two groups: 67 patients operated via posterior approach only and 64 operated via combined anterior/posterior approach. Read More

Indian J Pediatr 2018 09 3;85(9):818-819. Epub 2018 May 3.

Department of Pediatrics, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi, 110 095, India.

Hum Mol Genet 2018 05;27(R1):R40-R47

J. Craig Venter Institute, La Jolla, CA 92037, USA.

Cells are fundamental function units of multicellular organisms, with different cell types playing distinct physiological roles in the body. The recent advent of single-cell transcriptional profiling using RNA sequencing is producing 'big data', enabling the identification of novel human cell types at an unprecedented rate. In this review, we summarize recent work characterizing cell types in the human central nervous and immune systems using single-cell and single-nuclei RNA sequencing, and discuss the implications that these discoveries are having on the representation of cell types in the reference Cell Ontology (CL). Read More

Braz J Phys Ther 2018 Jul - Aug;22(4):310-317. Epub 2018 Mar 6.

The University of Newcastle, School of Health Sciences, Discipline of Physiotherapy, Callaghan, NSW, Australia.

Background: Radiographs are used to monitor thoracic kyphosis in individuals with certain pathologies (e.g. osteoporosis), exposing patients to potentially harmful radiation. Read More

Spine Deform 2018 Mar - Apr;6(2):177-184

Rady Children's Hospital San Diego, 3020 Children's Way, San Diego, CA 92123, USA.

Introduction: Sagittal alignment abnormalities in Scheuermann kyphosis (SK) strongly correlate with quality of life measures. The changes in spinopelvic parameters after posterior spinal fusion have not been adequately studied. This study is to evaluate the reciprocal changes in spinopelvic parameters following surgical correction for SK. Read More

Am J Respir Crit Care Med 2018 06;197(11):1433-1442

5 Clinic of Pediatric Pneumology, Allergology, and Neonatology and.

Rationale: The combination of the CFTR (cystic fibrosis transmembrane conductance regulator) corrector lumacaftor with the potentiator ivacaftor has been approved for the treatment of patients with cystic fibrosis homozygous for the Phe508del CFTR mutation. The phase 3 trials examined clinical outcomes but did not evaluate CFTR function in patients.

Objectives: To examine the effect of lumacaftor-ivacaftor on biomarkers of CFTR function in Phe508del homozygous patients with cystic fibrosis aged 12 years and older. Read More

BMC Bioinformatics 2017 12 21;18(Suppl 17):559. Epub 2017 Dec 21.

J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA, 92037, USA.

Background: A fundamental characteristic of multicellular organisms is the specialization of functional cell types through the process of differentiation. These specialized cell types not only characterize the normal functioning of different organs and tissues, they can also be used as cellular biomarkers of a variety of different disease states and therapeutic/vaccine responses. In order to serve as a reference for cell type representation, the Cell Ontology has been developed to provide a standard nomenclature of defined cell types for comparative analysis and biomarker discovery. Read More

Acta Orthop Traumatol Turc 2018 Jan 28;52(1):7-11. Epub 2017 Dec 28.

Acibadem University Atakent Hospital, Department of Orthopaedics and Traumatology, Istanbul, Turkey.

Objective: The aim of this study was to investigate the effect of distal fusion level selection on the distal junctional kyphosis (DJK) in Scheuermann kyphosis (SK) patients who underwent posterior fusion.

Methods: Thirty-nine SK patients who underwent posterior fusion with a minimum follow-up of 3 years were retrospectively evaluated. According to the distal fusion level, patients were divided into 3 groups. Read More

J Mol Cell Cardiol 2018 01 22;114:345-353. Epub 2017 Dec 22.

INSERM U1046, CNRS UMR 9214, Université de Montpellier, Physiologie et Médecine Expérimentale du cœur et des muscles - PHYMEDEXP, CHU Arnaud de Villeneuve, 34295 Montpellier cedex 05, France.. Electronic address:

Aim: Duchenne Muscular Dystrophy (DMD) is associated with progressive depressed left ventricular (LV) function. However, DMD effects on myofilament structure and function are poorly understood. Golden Retriever Muscular Dystrophy (GRMD) is a dog model of DMD recapitulating the human form of DMD. Read More

Spine (Phila Pa 1976) 2018 07;43(13):E758-E765

Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Study Design: A retrospective matched-cohort comparative study.

Objective: The aim of this study was to compare the surgical results after the use of duet screw based satellite rods and bilateral satellite rods (S-RC) versus a standard two-rod construct (2-RC) across osteotomy sites in a matched cohort with Scheuermann kyphosis (SK).

Summary Of Background Data: Multiple Ponte osteotomies are frequently employed to correct SK via a posterior-only approach, with a 2-RC across the osteotomy sites. Read More

Musculoskelet Surg 2018 Dec 17;102(3):257-260. Epub 2017 Nov 17.

Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Scheuermann kyphosis is the most common structural kyphosis among adolescence and young people. Surgical treatment may be performed through combined anterior and posterior or posterior-only approaches; to our knowledge, the efficacy of posterior-only approach as less invasive procedure is not well studied in case of severe rigid Scheuermann kyphosis.

Materials And Methods: Eighteen patients with severe rigid Scheuermann kyphosis operated through only posterior approach from 2013 to 2016 were evaluated. Read More

Clin Lab Med 2017 12;37(4):931-944

Department of Informatics, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037, USA.

Flow cytometry is used in cell-based diagnostic evaluation for blood-borne malignancies including leukemia and lymphoma. The current practice for cytometry data analysis relies on manual gating to identify cell subsets in complex mixtures, which is subjective, labor-intensive, and poorly reproducible. This article reviews recent efforts to develop, validate, and disseminate automated computational methods and pipelines for cytometry data analysis that could help overcome the limitations of manual analysis and provide for efficient and data-driven diagnostic applications. Read More

Neurosurg Focus 2017 Oct;43(4):E13

Department of Spine Surgery, Sparsh Hospital, Bangalore, India; and.

OBJECTIVE Neurogenic kyphoscoliosis in pediatric patients has varied causes and diverse management options. The most common management strategy is to stage the orthopedic and neurosurgical aspects of the correction at an interval of 3-6 months from each other. The aim of this study was to report the authors' experience with correction of deformity in children with associated neurological abnormalities requiring intervention as a single-stage surgical treatment. Read More

Sci Rep 2017 09 21;7(1):12094. Epub 2017 Sep 21.

Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, D-10117, Berlin, Germany.

Immunity in infection, inflammation and malignancy differs markedly in man and mouse. Still, we learn about human immunity in large extent from experimental mouse models. We propose a novel data integration approach which identifies concordant and discordant gene expression patterns of the immune responses in heterologous data sets. Read More