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Clin Spine Surg 2019 Feb 12. Epub 2019 Feb 12.

Department of Orthopedics, Peking University Third Hospital, Haidian District.

Study Design: This study was a systematic review and meta-analysis.

Objectives: To compare stable sagittal vertebra (SSV) and first lordotic vertebra (FLV) instrumentation for prevention of distal junctional kyphosis (DJK) in Scheuermann disease.

Summary Of Background Data: The SSV has been increasingly chosen as the lowest instrumented vertebra to prevent DJK, and some studies have provided supportive results. Read More

Asian Spine J 2019 Jan 24. Epub 2019 Jan 24.

Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences at Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Study Design: Randomized controlled single-blinded clinical trial.

Purpose: To evaluate the efficacy of Schroth therapy on thoracic curve angle, pain, and self-perceived body image (SPBI) of the back in Scheuermann's patients in comparison with the efficacy of classic anti-gravitation exercises.

Overview Of Literature: Scheuermann disease is the most common cause of hyperkyphosis of the thoracic and thoracolumbar spine during adolescence. Read More

Exp Lung Res 2018 May - Jun;44(4-5):201-210. Epub 2018 Nov 22.

a Department of Surgery , Duke University Medical Center , Durham , North Carolina , USA.

Aim Of The Study: The pulmonary microbiota is important for both normal homeostasis and the progression of disease, and may be affected by aspiration of gastric fluid. The aim of this study was to investigate changes in the lung microbiota induced by aspiration of gastric fluid in a laboratory rat model.

Material And Methods: Using the intratracheal application method, male rats received aspiration with 0. Read More

Spine Deform 2018 Nov - Dec;6(6):676-683

Department of Orthopaedic Surgery, Rady Children's Hospital San Diego, 3020 Children's Way, MC 5069, San Diego, CA 92123-4282, USA.

Study Design: Preoperative and two-year follow-up health-related quality of life (HRQOL) data were prospectively collected in 82 Scheuermann kyphosis (SK) and 995 adolescent idiopathic scoliosis (AIS) patients using the Scoliosis Research Society-22 patient questionnaire (SRS-22) outcomes instrument in a multicenter study. Visual analog scale (VAS) scores were also collected for the SK population.

Objectives: This study assessed changes in HRQOL prospectively and compared them to those occurring in AIS. Read More

EJNMMI Phys 2018 Oct 8;5(1):21. Epub 2018 Oct 8.

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Background: [F]Fluortriopride (FTP) was developed as a dopamine D3-selective radiotracer, thought to be important to neurobiological reward pathways and implicated in drug addiction, Parkinson's disease, and schizophrenia. Preclinical radiation dosimetry studies found the gallbladder wall received the highest dose. A gallbladder dose reduction intervention was simulated using a novel reduction model for healthy adults following fatty-meal consumption. Read More

Blood Adv 2018 Oct;2(19):2419-2429

Center for International Blood and Marrow Transplant Research, Minneapolis, MN.

Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a curative option for blood cancers, but the coupled effects of graft-versus-tumor and graft-versus-host disease (GVHD) limit its broader application. Outcomes improve with matching at HLAs, but other factors are required to explain residual risk of GVHD. In an effort to identify genetic associations outside the major histocompatibility complex, we conducted a genome-wide clinical outcomes study on 205 acute myeloid leukemia patients and their fully HLA-A-, HLA-B-, HLA-C-, HLA-DRB1-, and HLA-DQB1-matched (10/10) unrelated donors. Read More

Bone 2018 Dec 20;117:116-122. Epub 2018 Sep 20.

INSERM UMR 1033, University of Lyon, Lyon, France. Electronic address:

The aim was to assess the association of Scheuermann's disease (SCD) with fracture risk (vertebral, peripheral) and bone mineral density (BMD) in older men. SCD was assessed on the baseline lateral spine radiographs using the Berlin criteria in 766 men aged 50-85. We evaluated the association of SCD and its diagnostic criteria with incident fracture (vertebral over 7. Read More

New Phytol 2019 Jan 4;221(2):976-987. Epub 2018 Sep 4.

Department of Plant and Microbial Biology, University of Zurich, Zollikerstrasse 107, CH-8008, Zurich, Switzerland.

Wall-associated kinases (WAKs) have recently been identified as major components of fungal and bacterial disease resistance in several cereal crop species. However, the molecular mechanisms of WAK-mediated resistance remain largely unknown. Here, we investigated the function of the maize gene ZmWAK-RLK1 (Htn1) that confers quantitative resistance to northern corn leaf blight (NCLB) caused by the hemibiotrophic fungal pathogen Exserohilum turcicum. Read More

Asian Spine J 2018 Aug 27;12(4):697-702. Epub 2018 Jul 27.

Department of Orthopaedics and Traumatology, Emsey Hospital, Istanbul, Turkey.

Study Design: Retrospective study.

Purpose: This study aimed to determine the incidence of intraspinal pathologies (ISPs) in individuals with Scheuermann's kyphosis (SK) and to validate whether the routine use of magnetic resonance imaging (MRI) is necessary for preoperative evaluation.

Overview Of Literature: There are several studies on the necessity of routine MRI screening and prevalence of ISPs related to different types of scoliosis have been conducted. Read More

Spine J 2019 Feb 17;19(2):330-338. Epub 2018 Jul 17.

Department of Orthopedic Surgery, Hospital Ramón y Cajal, Ctra. de Colmenar Viejo, km. 9.100, Madrid 28034, Spain.

Background Context: The evaluation of ventilatory functional restrictions during a maximal exercise tolerance test in patients with Scheuermann disease has never been described.

Purpose: This study evaluated the respiratory functional capacity of patients with Scheuermann disease compared to healthy adolescents matched in age.

Study Design/setting: Prospective comparative study. Read More

Spine Deform 2018 Jul - Aug;6(4):397-402

Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences at Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address:

Study Design: A cross-cultural adaptation and reliability study.

Objective: To perform cross-cultural adaptation and evaluate the reliability and validity of the Hebrew version of the Scoliosis Research Society-22 (SRS-22) questionnaire.

Summary Of Background Data: The SRS-22 validated in different languages is used in assessing health-related quality of life of patients with scoliosis. Read More

Front Immunol 2018 8;9:976. Epub 2018 May 8.

Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Background: Recent technological advances in immune repertoire sequencing have created tremendous potential for advancing our understanding of adaptive immune response dynamics in various states of health and disease. Immune repertoire sequencing produces large, highly complex data sets, however, which require specialized methods and software tools for their effective analysis and interpretation.

Results: VDJServer is a cloud-based analysis portal for immune repertoire sequence data that provide access to a suite of tools for a complete analysis workflow, including modules for preprocessing and quality control of sequence reads, V(D)J gene segment assignment, repertoire characterization, and repertoire comparison. Read More

Eur Spine J 2018 Sep 19;27(9):2322-2330. Epub 2018 May 19.

Groupe Hospitalier Paris Saint-Joseph, 185, rue Raymond Losserand, 75014, Paris, France.

Purpose: The literature shows controversies concerning surgical treatment of Scheuermann's kyphosis between posterior-only fixation and combined anterior/posterior fusion. The aim of this study is to compare the clinical and radiological results and the rate of complications between these two techniques.

Methods: We performed a multicentric retrospective review of 131 patients who underwent primary fusion for Scheuermann's kyphosis divided into two groups: 67 patients operated via posterior approach only and 64 operated via combined anterior/posterior approach. Read More

Indian J Pediatr 2018 09 3;85(9):818-819. Epub 2018 May 3.

Department of Pediatrics, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi, 110 095, India.

Hum Mol Genet 2018 May;27(R1):R40-R47

J. Craig Venter Institute, La Jolla, CA 92037, USA.

Cells are fundamental function units of multicellular organisms, with different cell types playing distinct physiological roles in the body. The recent advent of single-cell transcriptional profiling using RNA sequencing is producing 'big data', enabling the identification of novel human cell types at an unprecedented rate. In this review, we summarize recent work characterizing cell types in the human central nervous and immune systems using single-cell and single-nuclei RNA sequencing, and discuss the implications that these discoveries are having on the representation of cell types in the reference Cell Ontology (CL). Read More

Braz J Phys Ther 2018 Jul - Aug;22(4):310-317. Epub 2018 Mar 6.

The University of Newcastle, School of Health Sciences, Discipline of Physiotherapy, Callaghan, NSW, Australia.

Background: Radiographs are used to monitor thoracic kyphosis in individuals with certain pathologies (e.g. osteoporosis), exposing patients to potentially harmful radiation. Read More

Spine Deform 2018 Mar - Apr;6(2):177-184

Rady Children's Hospital San Diego, 3020 Children's Way, San Diego, CA 92123, USA.

Introduction: Sagittal alignment abnormalities in Scheuermann kyphosis (SK) strongly correlate with quality of life measures. The changes in spinopelvic parameters after posterior spinal fusion have not been adequately studied. This study is to evaluate the reciprocal changes in spinopelvic parameters following surgical correction for SK. Read More

Am J Respir Crit Care Med 2018 Jun;197(11):1433-1442

5 Clinic of Pediatric Pneumology, Allergology, and Neonatology and.

Rationale: The combination of the CFTR (cystic fibrosis transmembrane conductance regulator) corrector lumacaftor with the potentiator ivacaftor has been approved for the treatment of patients with cystic fibrosis homozygous for the Phe508del CFTR mutation. The phase 3 trials examined clinical outcomes but did not evaluate CFTR function in patients.

Objectives: To examine the effect of lumacaftor-ivacaftor on biomarkers of CFTR function in Phe508del homozygous patients with cystic fibrosis aged 12 years and older. Read More

BMC Bioinformatics 2017 12 21;18(Suppl 17):559. Epub 2017 Dec 21.

J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA, 92037, USA.

Background: A fundamental characteristic of multicellular organisms is the specialization of functional cell types through the process of differentiation. These specialized cell types not only characterize the normal functioning of different organs and tissues, they can also be used as cellular biomarkers of a variety of different disease states and therapeutic/vaccine responses. In order to serve as a reference for cell type representation, the Cell Ontology has been developed to provide a standard nomenclature of defined cell types for comparative analysis and biomarker discovery. Read More

Acta Orthop Traumatol Turc 2018 Jan 28;52(1):7-11. Epub 2017 Dec 28.

Acibadem University Atakent Hospital, Department of Orthopaedics and Traumatology, Istanbul, Turkey.

Objective: The aim of this study was to investigate the effect of distal fusion level selection on the distal junctional kyphosis (DJK) in Scheuermann kyphosis (SK) patients who underwent posterior fusion.

Methods: Thirty-nine SK patients who underwent posterior fusion with a minimum follow-up of 3 years were retrospectively evaluated. According to the distal fusion level, patients were divided into 3 groups. Read More

Spine (Phila Pa 1976) 2018 07;43(13):E758-E765

Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Study Design: A retrospective matched-cohort comparative study.

Objective: The aim of this study was to compare the surgical results after the use of duet screw based satellite rods and bilateral satellite rods (S-RC) versus a standard two-rod construct (2-RC) across osteotomy sites in a matched cohort with Scheuermann kyphosis (SK).

Summary Of Background Data: Multiple Ponte osteotomies are frequently employed to correct SK via a posterior-only approach, with a 2-RC across the osteotomy sites. Read More

Clin Lab Med 2017 12;37(4):931-944

Department of Informatics, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037, USA.

Flow cytometry is used in cell-based diagnostic evaluation for blood-borne malignancies including leukemia and lymphoma. The current practice for cytometry data analysis relies on manual gating to identify cell subsets in complex mixtures, which is subjective, labor-intensive, and poorly reproducible. This article reviews recent efforts to develop, validate, and disseminate automated computational methods and pipelines for cytometry data analysis that could help overcome the limitations of manual analysis and provide for efficient and data-driven diagnostic applications. Read More

Neurosurg Focus 2017 Oct;43(4):E13

Department of Spine Surgery, Sparsh Hospital, Bangalore, India; and.

OBJECTIVE Neurogenic kyphoscoliosis in pediatric patients has varied causes and diverse management options. The most common management strategy is to stage the orthopedic and neurosurgical aspects of the correction at an interval of 3-6 months from each other. The aim of this study was to report the authors' experience with correction of deformity in children with associated neurological abnormalities requiring intervention as a single-stage surgical treatment. Read More

Sci Rep 2017 Sep 21;7(1):12094. Epub 2017 Sep 21.

Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, D-10117, Berlin, Germany.

Immunity in infection, inflammation and malignancy differs markedly in man and mouse. Still, we learn about human immunity in large extent from experimental mouse models. We propose a novel data integration approach which identifies concordant and discordant gene expression patterns of the immune responses in heterologous data sets. Read More

Int J Paleopathol 2017 09 11;18:26-37. Epub 2017 May 11.

GESPAD Al-Andalus S.L. Archaeology, 18010 Granada, Spain.

This study details a severe case of Scheuermann's disease (SD) in a well-preserved skeleton of a juvenile male (designated TOR302), dated to 3rd-4th century CE, from the late Roman necropolis of Torrenueva (Granada, Spain). Individual TOR302 shows an evident kyphotic curve in the thoraco-lumbar spine, which is characterised by: (i) vertebral bodies of thoracic vertebra T2, thoracic segment T4-T9, and thoraco-lumbar segment T12-L2 wedged at >5°; (ii) slight anterior extensions of the epiphyseal ring; (iii) Schmorl's nodes on the superior and/or inferior plates; and (iv) a Cobb angle of 75°, derived from thoracic segments T4-T9. In addition, TOR302 shows other skeletal malformations as the secondary results of abnormal growth, due to altered biomechanical forces imposed by the spinal deformity, including: (i) lateral distortion of the spine that causes a slight secondary scoliotic curve; (ii) pelvic obliquity; and (iii) discrepancy in the length of the limbs. Read More

PLoS One 2017 24;12(8):e0183027. Epub 2017 Aug 24.

Hospital for Children and Adolescents, University Leipzig, Leipzig, Saxony, Germany.

Nicotinamide phosphoribosyl transferase (NAMPT) is an inflammatory adipocytokine shown to interact in immune modulation in chronic inflammatory diseases, acute respiratory distress syndrome, sepsis, cancer and obesity in adulthood. It is, however, not clear whether this association reflects a chronic elevation or acute inflammatory response. We analyzed NAMPT concentrations in distinct states of inflammation in 102 children and found consistently significantly increased NAMPT levels in subjects with acute infections. Read More

Transl Pediatr 2017 Jul;6(3):225-235

Department of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, USA.

Lower back pain in young athletes is a common problem. The prevalence of back pain from different causes in adolescent age group is between 20% and 30%. However, the incidence of low back pain in young athletes varies widely in different sports. Read More

Clin Spine Surg 2017 Aug;30(7):E938-E941

*The Centre for Spinal Studies and Surgery, QMC, Nottingham University Hospitals NHS Trust, Nottingham, UK †Department of Neurosurgery and Neurooncology, First School of Medicine, Charles University and Military University Hospital Prague ‡Department of Anesthesiology and Intensive Care Medicine, Hospital Kralovske Vinohrady, Prague, Czech Republic.

Study Design: Retrospective, blinded analysis of imaging studies.

Objective: The aim of this study is compare the use of magnetic resonance imaging (MRI) to lateral radiograph using bolster in the evaluation of Scheuermann kyphosis (SK) curve flexibility measurement.

Summary And Background Data: The flexibility of the thoracic curve [thoracic kyphosis (TK)] in SK is of primary importance in its preoperative planning. Read More

J Craniovertebr Junction Spine 2017 Apr-Jun;8(2):136-143

Department of Orthopedic Surgery, Al Zahra Educational Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Scheuermann's disease is regarded as the most common cause of structural hyperkyphosis within adolescents without any proper treatment. It may lead to progressive deformity and back pain which influences patient's quality of life during adolescence and adulthood. Treatment approach to Scheuermann's kyphosis has not been clearly defined due to its different definitions and obscure natural history. Read More

Medicine (Baltimore) 2017 Jun;96(25):e7100

Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Rationale: Given that Scheuermann disease rarely occurs in the lumbar region and that the co-occurrence of Scheuermann disease and idiopathic scoliosis (IS) has not been reported-the etiology of Scheuermann disease and IS is not clear. In this case report, we present familaiar lumbar Scheuermann disease with IS, in a Chinese proband, who was successfully treated with surgery.

Patient Concerns: A 16-year-old boy presented at the Second XiangYa Hospital of Central South University with a chief complaint of kyphotic deformity in the lower back for 4 years and obvious lower back pain. Read More

Biochim Biophys Acta Mol Basis Dis 2017 09 15;1863(9):2229-2239. Epub 2017 Jun 15.

Inserm U1046, UMR CNRS 9214, Université Montpellier, CHRU Montpellier, Montpellier, France. Electronic address:

Besides its role in calcium (Ca) homeostasis, the sarco-endoplamic reticulum (SR/ER) controls protein folding and is tethered to mitochondria. Under pathophysiological conditions the unfolded protein response (UPR) is associated with disturbance in SR/ER-mitochondria crosstalk. Here, we investigated whether ER stress altered SR/ER-mitochondria links, Ca handling and muscle damage in WT (Wild Type) and mdx mice, the murine model of Duchenne Muscular Dystrophy (DMD). Read More

Clin Spine Surg 2017 Jun;30(5):E560-E566

Department of Orthopaedics ChangZheng Hospital Affiliated to Second Military Medical University, Shanghai, China.

Objective: The aim of this study was to analyze the radiologic features of adolescent idiopathic cervical kyphosis.

Summary Of Background Data: There are few previous reports about radiographic analysis of cervical sagittal alignment of adolescent idiopathic cervical kyphosis. A new method was proposed in this article to evaluate the severity of cervical kyphosis. Read More

Virus Evol 2016 Jan 15;2(1):vew015. Epub 2016 Jun 15.

J. Craig Venter Institute, La Jolla, CA, USA.

Enterovirus D68 (EV-D68) caused a severe respiratory illness outbreak in the United States in 2014. Reports of acute flaccid myelitis (AFM)/paralysis (AFP) in several independent epidemiological clusters of children with detectable EV-D68 have raised concerns that genetic changes in EV-D68 could be causing increased disease severity and neurological symptoms. To explore the potential link between EV-D68 genetic variations and symptom changes, we performed a series of comparative genomic analyses of EV-D68 2014 outbreak isolate sequences using data and analytical tools in the Virus Pathogen Resource (ViPR; www. Read More

Brain Behav Immun 2017 Oct 27;65:140-149. Epub 2017 Apr 27.

Division of Immunology, Department of Biology, University of Konstanz, D-78457 Konstanz, Germany; Biotechnology Institute Thurgau (BITg) at the University of Konstanz, CH-8280 Kreuzlingen, Switzerland.

Animal tumor models and human cancer studies have provided convergent evidence that chronic psychological stress plays a decisive role in modulating anti-tumor T cell immunity. However, whether chronic stress also affects anti-cancer vaccine strategies that rely on the induction of functional tumor-specific T cells has not been investigated yet. In this study we provide direct evidence that chronic stress suppresses the therapeutic efficacy of a biodegradable poly(d,l-lactide-co-glycolide) microsphere (PLGA-MS) based cancer vaccine in a murine melanoma model. Read More

Eur Spine J 2017 08 19;26(8):2187-2197. Epub 2017 Apr 19.

The Centre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham, NG7 2UH, UK.

Purpose: To analyse pre-operative and post-operative changes of cervical sagittal alignment (CSA) in Scheuermann's kyphosis (SK) patients.

Methods: 64 SK and 33 control patients were retrospectively reviewed. Whole spine X-rays obtained at pre-op, 3 months post-op and at latest follow-up were reviewed and ten separate CSA radiological parameters were measured. Read More

J Orthop Sci 2017 Jul 15;22(4):652-657. Epub 2017 Apr 15.

Orton Orthopaedic Hospital and Orton Research Institute, Orton Foundation, Tenholantie 10, PL 29, 00281, Helsinki, Finland. Electronic address:

Background: There is no data available on the radiographic development of the Scheuermann's deformity. Our purpose was to investigate radiographic deformity progression and the relation between kyphosis progression and clinical outcome in patients with untreated Scheuermann's kyphosis.

Methods: Thoracic kyphosis (Th4-Th12) was measured from standing lateral radiographs in 19 patients at baseline and after mean 46-year follow-up. Read More

Medicine (Baltimore) 2017 Mar;96(12):e6199

aLudwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, First Medical Department, Hanusch Hospital bOrthopedic Hospital of Speising, Pediatric Department, Vienna, Austria cDepartment of Neonatology, Charles Nicolle Hospital, Tunisia dDepartment of Pediatric Orthopedic Surgery, Children Hospital of Tunis, Tunisia. eInstitute of Medical Chemistry, Medical University of Vienna, Austria.

Rationale: Craniosynostosis is a disorder characterized by premature fusion of cranial sutures with subsequent development of abnormal craniofacial contour associated with variable skeletal and extra-skeletal abnormalities. In this family syndromic type of craniosynostosis was recognized and the etiology behind diverse forms of deformities have been diagnosed.

Patient Concerns: The negative impact of the disorder on the child and his family is enormous. Read More

BMC Musculoskelet Disord 2017 03 16;18(1):112. Epub 2017 Mar 16.

Department of Spine Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Background: A previous study reported a high prevalence of spinal epidural lipomatosis (SEL) in patients with Scheuermann kyphosis (SK) and suggested that it may play a role in the pathogenesis of this disease. According to our observation, however, SEL occurs in other spinal kyphotic deformities as well. The aim of this study was to test the hypothesis that SEL commonly occurs in patients with different types of kyphotic deformities as a secondary intraspinal disorder. Read More

Spine Deform 2017 03;5(2):124-133

Department of Orthopedic Surgery, Rady Children's Hospital, 3020 Children's Way, San Diego, CA 92123, USA.

Study Design: Patients with preoperative spine magnetic resonance imaging (MRI) studies from a prospective multicenter study of operative adolescent Scheuermann kyphosis (SK).

Objectives: To investigate the usefulness of MRI screening in operative planning for SK surgeries.

Summary Of Background Data: Neural axis abnormalities in operative SK have not been previously studied with MRI screening, despite its use. Read More

J Pediatr Orthop 2017 Jan 30. Epub 2017 Jan 30.

*Department of Orthopaedic Surgery, University of Minnesota, Minneapolis **Mayo Clinic, Rochester, MN †Edwards Life Sciences, Irvine, CA ‡St. Justine's Hospital, Montreal, QC, Canada §Texas Scottish Rite Hospital for Children, Dallas, TX ∥Boston Children's Hospital, Boston, MA ¶Columbia University, New York, NY #Children's Hospital, Aurora, CO.

Background: Surgical indications for Scheuermann kyphosis are variable. We sought to evaluate the characteristics of patients undergoing operative versus nonoperative treatment of Scheuermann kyphosis to better understand current practices and the factors which contribute to the decision for surgical management.

Methods: Multicenter prospective cohort study. Read More

Joint Bone Spine 2017 May 25;84(3):345-348. Epub 2017 Jan 25.

Service de rééducation et réadaptation de l'appareil locomoteur et des pathologies du rachis, hôpital Cochin, AP-HP, 75014 Paris, France; Inserm U1153, faculté de médecine Paris-Descartes, 75006 Paris, France.

Background: Neurological complications in Scheuermann's disease are rare but serious.

Case Reports: We report three cases of severe neurological deficit due to medullar ischemia attributable to the compression of a radiculomedullar artery by thoracic (two cases) and lumbar (one case) disc herniations associated with Scheuermann's disease. They were not treated surgically because of the absence of direct spinal cord compression or definitive spinal cord ischemia. Read More

Eur Spine J 2017 03 31;26(3):913-920. Epub 2016 Dec 31.

Center for Spinal Studies, Queens Medical Center, Nottingham University, Derby Road, Nottingham, NG7 2UH, UK.

Purpose: To investigate the relationship between preoperative and postoperative spinopelvic alignment and occurrence of DJK/DJF.

Study Design/setting: This was a retrospective observational cohort study.

Patient Sample: The sample included 40 patients who underwent posterior correction of SK from January 2006 to December 2014. Read More

mSphere 2016 Nov-Dec;1(6). Epub 2016 Dec 14.

Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, Ames, Iowa, USA.

The H1 subtype of influenza A viruses (IAVs) has been circulating in swine since the 1918 human influenza pandemic. Over time, and aided by further introductions from nonswine hosts, swine H1 viruses have diversified into three genetic lineages. Due to limited global data, these H1 lineages were named based on colloquial context, leading to a proliferation of inconsistent regional naming conventions. Read More

World J Radiol 2016 Nov;8(11):895-901

Erkan Gokce, Department of Radiology, School of Medicine, Gaziosmanpaşa University, 60100 Tokat, Turkey.

Aim: To find accompanying anomalies of typical and atypical Scheuermann's disease (SD) is reported in the present study.

Methods: Study included 20 patients (16 men and 4 women) who had radiological imaging radiography, magnetic resonance imaging (MRI) and computed tomography, if available, due to back pain, curved back and low back pain in November 2011-February 2016 period. Patients were categorized into typical and atypical patterns based on the region involved. Read More

Antiviral Res 2017 01 1;137:23-40. Epub 2016 Nov 1.

Vere Hodge Antivirals Ltd, Old Denshott, Leigh, Reigate, Surrey, UK. Electronic address:

The 29th International Conference on Antiviral Research (ICAR) was held in La Jolla, CA, USA from April 17 to 21, 2016. This report opens with a tribute to the late Chris McGuigan, a Past-President of ISAR, then continues with summaries of the principal invited lectures. Doug Richman (Elion Award) investigated HIV resistance, Bob Vince (Holý Award) showed how carbocyclic nucleoside analogs led to abacavir and Jerome Deval (Prusoff Award) explained how his group chose to seek a nucleoside analog to treat RSV. Read More

Scoliosis Spinal Disord 2016 14;11(Suppl 2):30. Epub 2016 Oct 14.

Scoliosis Spine Laser Centre, Athens, 18346 Greece.

Background: Most recent publications have provided evidence for brace treatment in spinal deformities. The purpose of this study was to evaluate the rate of overtreatment for AIS and Kyphosis in Greece, according to the Society on Scoliosis Orthopedic Rehabilitation Treatment (SOSORT) and the Scoliosis Research Society (SRS) guidelines for brace treatment. To date, this is the first study to investigate overtreatment percentage in a group of patients with spinal deformities. Read More

Nucleic Acids Res 2017 01 26;45(D1):D466-D474. Epub 2016 Sep 26.

J. Craig Venter Institute, La Jolla, CA 92037, USA

The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. Read More

Eur Spine J 2017 03 3;26(3):928-936. Epub 2016 Sep 3.

Department of Orthopedics and Traumatology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Purpose: To comparatively evaluate the biomechanical alterations those occur in the sagittal plane of sacropelvic junction in angular kyphosis (AK) and Scheuermann kyphosis (SK) patients after surgery.

Methods: The spine radiographs of 52 patients operated for short-segment AK (n = 20) or SK (n = 32) were studied. Main outcome measures were sacral slope, pelvic incidence, pelvic tilt, lumbar lordosis, and thoracic kyphosis angles. Read More

Acta Orthop Belg 2016 Sep;82(3):467-473

To measure the cross-sectional area (CSA) of para-spinal muscles in Scheuermann's kyphosis patients. Preoperative MRI images of 16 Scheuermann's kyphosis patients were analysed and compared to 16 patients with normal MRI images (control group). The CSAs were measured at L3-4 and L4-5. Read More