53,500 results match your criteria Scarring Alopecia


Endoscopic medialization middle turbinoplasty in endoscopic sinus surgery.

Ear Nose Throat J 2018 Dec;97(12):404-410

Department of Otolaryngology-Head and Neck Surgery, Tufts University School of Medicine, Tufts Medical Center, 800 Washington St., Box 850, Boston, MA 02111, USA. Email:

Recurrence of sinonasal disease can be caused by many factors, including lateralization of the middle turbinate as a complication of endoscopic sinus surgery (ESS). Different ESS procedures have been tried to prevent this complication. We conducted a prospective study to determine if medialization is an effective means of lateralizing the middle turbinate. Read More

View Article
December 2018

Margin Status and Duration of Surgery in Resection of Tongue Carcinoma with Ultrasound Coagulation Device: a Comparative Study.

Indian J Surg Oncol 2018 Dec 20;9(4):501-504. Epub 2018 Jul 20.

Department of Otolaryngology and Head Neck Surgery, Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India.

Tongue is one of the most common subsites involved by oral cancer. Improved surgical care and adjuvant therapy, along with better rehabilitation has significantly improved long-term survival and quality of life in patients with oral cancer. Primary surgical treatment is the preferred modality of treatment in cancers of the oral tongue. Read More

View Article
December 2018

Promotion of skin wound healing using prevascularized oral mucosal cell sheet.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: This study examined the potential use of our newly developed prevascularized oral mucosal cell sheet for the treatment of skin wounds.

Methods: Mucosal cell sheets containing cultured keratinocytes and plasma fibrin without (K sheet) or with a mixture of fibroblasts and endothelial progenitor cells (PV sheet) were transplanted into full-thickness skin excisional wounds of nude mice.

Results: This technique was successful for in vitro culture; expanding keratinocytes, fibroblasts, and endothelial progenitor cells; and generating prevascularized mucosal cell sheets. Read More

View Article
December 2018
2 Reads

[Experience in visceral cutaneous and cutaneous loxoscelism of hospital management: clinical, evolution and therapeutic proposal].

Rev Chilena Infectol 2018 ;35(3):266-275

Departamento de Dermatología, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Loxoscelism is a common pathology in our environment with a broad spectrum of differential diagnoses and presentations, with potentially serious complications, even to the point of death. To date, there is no standard treatment for these patients.

Aim: To describe the clinical manifestations, main complications, therapeutic management, and evolution of loxoscelism in an inpatient setting from a tertiary hospital in Chile. Read More

View Article
January 2018

A novel model for cutaneous wound healing and scarring in the rat.

Plast Reconstr Surg 2018 Nov 26. Epub 2018 Nov 26.

Si-Zheng Zhou, Wen-Jin Wang and Shuang-Bai Zhou contributed equally to this work and should be considered co-first authors.

Background: Current rodent models of wound healing and scarring are flawed due to rapid wound contraction and inconspicuous scarring after healing, which is not closely parallel to the physiological process in human. This study was designed to establish a novel model of wound healing and scarring in rats.

Methods: Excisional wounds were generated in rat tail or dorsal skin and assessed in terms of histological changes and wound contraction 2, 10 and 16 days postinjury. Read More

View Article
November 2018

Femtosecond Laser-Assisted Deep Lamellar Descemet Membrane Endothelial Keratoplasty for the Treatment of Endothelial Dysfunction Associated With Posterior Stromal Scarring.

Cornea 2018 Dec 7. Epub 2018 Dec 7.

Cornea, Cataract and Refractive Surgery Unit, Vissum Corporación, Alicante, Spain.

Purpose: To describe an alternative surgical approach, femtosecond laser-assisted deep lamellar Descemet membrane endothelial keratoplasty (Femto-DL-DMEK), for the treatment of corneal endothelial diseases associated with posterior stromal scarring.

Methods: Case report of a 52-year-old man with pseudophakic bullous keratopathy and posterior corneal scarring secondary to viral endotheliitis who underwent Femto-DL-DMEK. The surgical technique was as follows: First, a manual lamellar dissection plane was created at approximately 75% to 85% depth through a 5. Read More

View Article
December 2018

Comparison of retroauricular and small transcervical approaches for endoscopic-assisted selective neck dissection: a cadaveric study.

Authors:
S Lee W Nam

Int J Oral Maxillofac Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, Republic of Korea. Electronic address:

Advances in endoscopic-assisted neck surgery have allowed surgeons to conceal the scars via various approaches. However, studies comparing the approaches are still rare. The aim of this study was to comparatively analyze the feasibility and oncological outcomes of the retroauricular approach (RA) and the small transcervical approach (STC) for endoscopic-assisted selective neck dissection (EASND). Read More

View Article
December 2018

Application of amniotic membrane in reconstructive urology; the promising biomaterial worth further investigation.

Expert Opin Biol Ther 2018 Dec 6. Epub 2018 Dec 6.

e Chair of Urology, Department of Regenerative Medicine, Collegium Medicum , Nicolaus Copernicus University , Bydgoszcz , Poland ;

Introduction: In reconstructive urology, autologous tissues such as intestinal segments, skin, and oral mucosa are used. Due to their limitations, reconstructive urologists are waiting for a novel material, which would be suitable for urinary tract wall replacement. Human amniotic membrane (AM) is a naturally derived biomaterial with a capacity to support reepithelization and inhibit scar formation. Read More

View Article
December 2018
3 Reads

Role of adolescent exposure to rockets in the links between personality vulnerability and psychopathology.

Dev Psychopathol 2018 Dec 6:1-14. Epub 2018 Dec 6.

Department of Psychology,Georgia State University,Atlanta,GA,USA.

The aim of this study is to examine the role of repeated exposure to rocket attacks in the links between personality vulnerability (dependency and self-criticism) and internalizing/externalizing psychopathology. A main-effect vulnerability model (personality leads to psychopathology) was compared with a main-effect scarring model (psychopathology leads to personality vulnerability). Also, a stress-diathesis pattern (personality vulnerability is activated under stress) was compared to a dual-vulnerability pattern (either personality vulnerability or stress, but not both, lead to psychopathology). Read More

View Article
December 2018

Rebound effect associated with JAK inhibitor use in the treatment of alopecia areata.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Tufts Medical Center, Boston, MA.

Alopecia areata (AA) is a common autoimmune disease driven by Th1 cytokines characterized by non-scarring hair loss. Mouse models have demonstrated that IFN-γ-producing NKG2D+ CD8+ cytotoxic T lymphocytes (CTLs) are essential for disease pathogenesis, along with JAK-STAT dependent cytokines IFN-γ and IL-15, which induce autoreactive T cell activation. This article is protected by copyright. Read More

View Article
December 2018
1 Read

The Ocular Status of Cystinosis Patients Receiving a Hospital Pharmacy-Made Preparation of Cysteamine Eye Drops: A Case Series.

Ophthalmol Ther 2018 Dec 5. Epub 2018 Dec 5.

Manchester Royal Eye Hospital, Manchester Academic Health Science Centre, Manchester, UK.

Introduction: Infantile nephropathic cystinosis (INC) is an autosomal recessive lysosomal disorder in which patients develop deposits of cystine crystals in their kidneys and corneas from a young age.

Methods: We conducted a retrospective analysis of children with INC seen by ophthalmologists at the Manchester Royal Eye Hospital between 2002 and 2018, to evaluate clinical findings, symptoms and treatment.

Results: Twenty-two children diagnosed with INC from age 0 (prenatally) to 11 years were assessed. Read More

View Article
December 2018
5 Reads

Prospective randomised controlled trial of Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts.

Burns Trauma 2018 27;6:33. Epub 2018 Nov 27.

Pegg Leditschke Children's Burns Centre, Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland Australia.

Background: This is a parallel three-arm prospective randomised controlled trial (RCT) comparing Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts (STSG). All three were in current use within the Pegg Leditschke Children's Burn centre (PLCBC), the largest paediatric burns centre in Queensland, Australia. Our objective was to find the best performing dressing, following on from previous trials designed to rationalise dressings for the burn wound itself. Read More

View Article
November 2018
1 Read

Hidradenitis Suppurativa: Causes, Features, and Current Treatments.

J Clin Aesthet Dermatol 2018 Oct 1;11(10):17-23. Epub 2018 Oct 1.

Drs. Vinkel and Thomsen are with the Department of Dermatology at Bispebjerg Hospital in Copenhagen, Denmark.

Hidradenitis suppurativa (HS), a relatively common and chronic inflammatory skin disorder. HS can have debilitating consequences if not diagnosed and treated appropriately. Clinically defined by recurrent, inflamed nodules in intertriginous regions (i. Read More

View Article
October 2018
2 Reads

Comparative Transcriptomics of Rat and Axolotl After Spinal Cord Injury Dissects Differences and Similarities in Inflammatory and Matrix Remodeling Gene Expression Patterns.

Front Neurosci 2018 13;12:808. Epub 2018 Nov 13.

Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, United Kingdom.

Following spinal cord injury in mammals, maladaptive inflammation, and matrix deposition drive tissue scarring and permanent loss of function. In contrast, axolotls regenerate their spinal cord after severe injury fully and without scarring. To explore previously unappreciated molecules and pathways that drive tissue responses after spinal cord injury, we performed a 4-way intersection of rat and axolotl transcriptomics datasets and isolated shared genes with similar or differential expression at days 1, 3, and 7 after spinal cord injury in both species. Read More

View Article
November 2018

Efficacy of a repair cream containing Rhealba oat plantlets extract l-ALA-l-GLU dipeptide, and hyaluronic acid in wound healing following dermatological acts: a meta-analysis of >2,000 patients in eight countries corroborated by a dermatopediatric clinical case.

Clin Cosmet Investig Dermatol 2018 13;11:579-589. Epub 2018 Nov 13.

Pierre Fabre Dermo-Cosmétique, A-DERMA, Lavaur, France,

Background: The frequency of dermatological acts is increasing. These procedures often cause injuries and traumatic alterations in specific skin layers, slowing down wound healing.

Patients And Methods: An open observational study lasting 1 month was conducted on 2,363 patients who had undergone various dermatological procedures. Read More

View Article
November 2018
2 Reads

Outcomes of long-pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma: A retrospective review.

Lasers Surg Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Dermatology, University of California, San Diego School of Medicine, 9500 Gillman Drive, La Jolla, California, 92093.

Background And Objective: Recent prospective trials have supported treatment of nonfacial BCC with long-pulsed 1064 nm Nd:YAG laser based on short-term histologic clearance rates. Studies have yet to identify the long-term clinical clearance rates of this specific laser therapy for BCC.

Study Design/material And Methods: This is a retrospective review of BCC treated with long-pulsed 1064 nm Nd:YAG laser, which have been clinically monitored for at least 6 months, to assess for recurrence and cosmetic outcomes of the treated area. Read More

View Article
December 2018

Use of Modified Islanded Paramedian Forehead Flap for Complex Periocular Facial Reconstruction.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Plastic Surgery, PGIMER, Chandigarh, India.

The paramedian forehead flap is a workhorse flap for reconstructing the nose and periorbital regions. Many variants are described including an islanded flap. However, eyebrow reconstruction is not usually performed with these flaps. Read More

View Article
November 2018

A review of the role of epidural percutaneous neuroplasty.

Pain Manag 2018 Dec 3. Epub 2018 Dec 3.

Vice Chair for Research & Education, Department of Anesthesiology & Pain Management, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA.

Degeneration, whether from age or postsurgical, in the ventral and lateral epidural space can lead to irritation of both the nerve roots and of the nerves present in the epidural space, the peridural membrane and the posterior longitudinal ligament. This irritation is often accompanied by mild scarring. Neuroplasty is a specific procedure designed to relieve this irritation. Read More

View Article
December 2018
1 Read

Integrative analyses of genes associated with idiopathic pulmonary fibrosis.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Radiotherapy, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China.

Idiopathic pulmonary fibrosis (IPF), characterized by irreversible scarring and progressive destruction of the lung tissue, is one of the most common types of idiopathic interstitial pneumonia worldwide. However, there are no reliable candidates for curative therapies. Hence, elucidation of the mechanisms of IPF genesis and exploration of potential biomarkers and prognostic indicators are essential for accurate diagnosis and treatment of IPF. Read More

View Article
December 2018

Human amniotic fluid stem cells have a unique potential to accelerate cutaneous wound healing with reduced fibrotic scarring like a fetus.

Hum Cell 2018 Dec 1. Epub 2018 Dec 1.

Department of Obstetrics and Gynecology, Keio University School of Medicine, 35, Shinanomachi Shinjyukuku, Tokyo, 160-8582, Japan.

Adult wound healing can result in fibrotic scarring (FS) characterized by excess expression of myofibroblasts and increased type I/type III collagen expression. In contrast, fetal wound healing results in complete regeneration without FS, and the mechanism remains unclear. Amniotic fluid cells could contribute to scar-free wound healing, but the effects of human amniotic fluid cells are not well characterized. Read More

View Article
December 2018
1 Read

The epidemiology of nonviral microbial keratitis in a tertiary care center in Muscat, Oman.

Oman J Ophthalmol 2018 Sep-Dec;11(3):213-219

Department of Ophthalmology, Al-Nahdah Hospital, Muscat, Oman.

Objective: The objective of this study is to describe the epidemiology, risk factors, etiology, and outcome of microbial keratitis in a tertiary care center in Muscat, Oman.

Methods: The electronic records of all patients diagnosed with keratitis or corneal ulcer between January 2013 and January 2016 in Al-Nahdha Hospital were retrospectively reviewed. Patients who presented with a corneal ulcer requiring admission and who underwent culture and sensitivity studies were included in the study. Read More

View Article
December 2018

Transverse cervical vascular pedicle: It's extended use as 'second-line' recipient vessels in thoracic and upper arm reconstructions in addition to head-and-neck reconstructions.

Indian J Plast Surg 2018 May-Aug;51(2):182-189

Department of Plastic and Reconstructive Surgery, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.

Background: Selection of recipient vessels is one of the key factors for a successful microvascular reconstruction. Non-availability of primary recipient vessels in the vicinity necessitates surgeon to approach a remote second-line vascular access. Transverse cervical vessels (TCV) have been described as second-line vascular access for head-and-neck reconstructions. Read More

View Article
December 2018

Evaluation of plastic compressed collagen for conjunctival repair in a rabbit model.

Tissue Eng Part A 2018 Dec 1. Epub 2018 Dec 1.

University Hospital Düsseldorf, Department of Ophthalmology , Moorenstrasse 5 , Düsseldorf, Germany , 40225 ;

Conjunctival repair is a crucial part of ocular surface reconstruction. Due to limitations of currently used substitute tissues, there is a need for the development of new scaffolds of consistent quality for conjunctival reconstruction. This study explored the biocompatibility and surgical usability of plastic compressed collagen (PCC) as an alternative conjunctival substitute. Read More

View Article
December 2018
1 Read

Novel pharmacotherapy for burn wounds: what are the advancements.

Expert Opin Pharmacother 2018 Dec 5:1-17. Epub 2018 Dec 5.

a Wellman Center for Photomedicine , Massachusetts General Hospital , Boston , MA , USA.

Introduction: The prognosis for severe burns has improved significantly over the past 50 years. Meanwhile, burns have become an affliction mainly affecting the less well-developed regions of the world. Early excision and skin grafting has led to major improvements in therapeutic outcomes. Read More

View Article
December 2018
5 Reads

Utilization of Anterolateral Thigh Flap and Transverse Cervical Recipient Vessels for Head and Neck Cancer Patients With Former Neck Dissection and Irradiation: A Case Series Study.

Ann Plast Surg 2018 Dec 3. Epub 2018 Dec 3.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Asia University Hospital, Asia University College of Medical and Health Science, Taichung, Taiwan.

Purpose: Free flap reconstruction in head and neck cancer patients with prior tumor resection, neck dissection, and irradiation is clinically challenging. The purpose of this study was to investigate the reliability and outcome of using the anterolateral thigh (ALT) flap and transverse cervical recipient vessels for microvascular reconstruction in patients with depleted vessels in the head and neck region caused by previous surgery and irradiation.

Methods: Between January 2015 and December 2017, microsurgical head and neck reconstruction was performed using the ALT flap and transverse cervical artery (TCA) as the recipient vessel in 15 patients who had undergone previous neck dissections and irradiation for cancer treatment. Read More

View Article
December 2018

Vesicoureteral Reflux and Renal Scarring in Infants After the First Febrile Urinary Tract Infection.

Med Arch 2018 Oct;72(4):272-275

Clinic for Nuclear Medicine, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Introduction: The objective of this research was to determine whether vesicoureteral reflux(VUR) was associated with evolution to renal scarring (RS) following a febrile urinary tract infection (UTI) in infants.

Materials And Methods: Our research included 100 infants, ages up to 1 year with a first febrile UTI. The diagnostic was based on results of: laboratory findings, ultrasonography (USG), voiding cystourethrography (VCUG) and initial and control renal scintigraphy (DMSA renal scan) withtechnetiumTcsuccimer (dimercaptosuccinic acid), to assess the acute pyelonephritis (APN), VUR and RS. Read More

View Article
October 2018
1 Read

[Anti-scarring effect of rapamycin in rabbits following glaucoma filtering surgery].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1389-1394

Center of Myopia, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.

Objective: To study the anti- scarring effect of rapamycin in rabbits receiving glaucoma filtering surgery.

Methods: Ninety-six Chinchilla rabbits were randomized equally into 3 rapamycin treatment groups and one control group. All the rabbits underwent trabeculectomy, after which the rabbits in the 3 rapamycin groups were treated with eye drops containing 1%, 3%, or 5% rapamycin in the operated eyes, and those in the control groups were given castor oil 4 times a day. Read More

View Article
November 2018
4 Reads

Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of Alopecia Areata.

J Dermatolog Treat 2018 Dec 4:1-26. Epub 2018 Dec 4.

a International Hair Research Foundation , Milan , Italy.

Background Alopecia areata (AA) is a non-scarring auto-immune hair disorder. Recent researches explained the role of growth factors (GFs) in hair follicle cycling. The main reservoir of GFs are alpha-granules of platelets and novel procedures have been implemented aimed at collecting platelet-rich plasma (PRP). Read More

View Article
December 2018

Alar Cinching with Subcutaneous Flaps: A Procedure to Achieve Narrowing of the Nasal Base while Controlling the Alar Axis and Sidewall Curvature.

Plast Reconstr Surg 2018 Nov;142(5):1165-1176

Tokyo and Tochigi, Japan; and Singapore, Singapore From the Ritz Cosmetic Surgery Clinic; the Department of Plastic Surgery, Jichi Medical University; and the Alaxis Medical & Aesthetic Surgery Clinic.

Background: Insufficient narrowing of alar width, alar distortion, and noticeable scarring are commonly encountered after alar base reduction. The authors aimed to demonstrate an alar cinching with subcutaneous flaps procedure to reduce the alar width while controlling the alar axis and sidewall curvature.

Methods: A retrospective chart review of 560 patients who underwent alar base reduction between 2000 and 2015 was performed. Read More

View Article
November 2018
1 Read

[Radical treatment of hidradenitis suppurativa: Comparison of the use of the artificial dermis and pedicled perforator flaps].

Ann Chir Plast Esthet 2018 Nov 30. Epub 2018 Nov 30.

Département de chirurgie plastique, reconstructrice, brûlés, plaies et cicatrisation, CHU Lapeyronie, 371, avenue du Doyen Gaston-Giraud, 34295 Montpellier, France; Département de chirurgie plastique et craniofaciale pédiatrique, CHU Lapeyronie, 34295 Montpellier, France. Electronic address:

Objectives: The objective of this study was to compare the use of artificial dermal and perforator flap after radical surgery of severe axillary and perineal hidradenitis suppurativa disease.

Patients And Methods: The data on postoperative outcomes, scar assessment (POSAS) and quality of life (DLQI, SF-36) were collected during consultation or by phone call. Forty-seven patients were included in our study between January 2015 and September 2017, including 27 patients in the artificial dermal group and 20 patients in the perforator flap group. Read More

View Article
November 2018

Editorial Commentary: When Less Is More-The Benefits of Limiting Bursectomy in Arthroscopic Rotator Cuff Repair.

Arthroscopy 2018 Dec;34(12):3175-3176

Although the exact function of the subacromial bursa as it relates to rotator cuff repair is still debatable, most surgeons would agree that the more invasive the procedure, the more likely there will be scarring and/or adhesions, which can lead to decreased motion. So, when performing subacromial bursectomy during rotator cuff repair, "Observe due measure, moderation is best in all things [subacromial]." Read More

View Article
December 2018
1 Read

Comparison of the diagnostic efficiency for local recurrence of rectal cancer using CT, MRI, PET and PET-CT: A systematic review protocol.

Medicine (Baltimore) 2018 Nov;97(48):e12900

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University.

Background: The risk of local recurrence (LR) continues to threat patients with rectal cancer after surgery or chemoradiotherapy. The main reason is that there is frequently extensive scarring and reactive changes after radiotherapy and resection. Thus, the diagnosis of LR can be challenging. Read More

View Article
November 2018

Integrated Cooling-Vacuum-Assisted Non-Fractional 1540-nm Erbium:Glass Laser: A New Modality for the Simultaneous Effective Treatment of Acne Lesions and Scars

J Drugs Dermatol 2018 11;17(11):1173 - 1176

Introduction: Acne vulgaris is a common skin disorder with a significant impact on patients' quality of life. There is currently no treatment designated to treat acne lesions and scars concurrently. However, mid-infrared lasers may promote neocollagenesis within atrophic scars, while exerting a beneficial effect on acne lesions. Read More

View Article
November 2018
2 Reads

IgG4-related kidney disease and retroperitoneal fibrosis: An update.

Mod Rheumatol 2018 Nov 30:1-24. Epub 2018 Nov 30.

c Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine , Fukuoka University , Fukuoka , Japan.

The most representative kidney lesion of IgG4-related disease (IgG4-RD) is plasma cell-rich tubulointerstitial nephritis (TIN) with distinctive imaging findings including multiple low-density lesions on contrast-enhanced computed tomography. In addition, membranous glomerulonephritis is a representative glomerular lesion of this disease. Recent advances have clarified that inflammation with IgG4-positive plasma cell infiltrates is not restricted to the renal parenchyma, but can be seen in outside the renal capsule, around medium-sized arteries such as lobar arteries, around nerves, and in the renal pelvis and periureter. Read More

View Article
November 2018
5 Reads

[Glaucoma surgery: from traditional filtration techniques to modern principles of bioengineering].

Vestn Oftalmol 2018 ;134(5):111-117

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

The article reviews the history of glaucoma surgery and analyses the connection between the accumulation of knowledge on glaucoma progression and the emergence of effective surgical treatment methods based on glaucoma pathogenesis. It also describes modern principles of preventing filtering bleb scarring. Particular attention is devoted to biodegradable collagen matrix implants. Read More

View Article
January 2018
2 Reads

[Influence of cataract phacoemulsification on eye hydrodynamics in patients with prior trabeculectomy].

Vestn Oftalmol 2018 ;134(5):99-103

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

At present, phacoemulsification and trabeculectomy are the most widespread surgery methods in cataract and glaucoma treatment, generally recognized as the gold standard. Among elderly patients, comorbid glaucoma and cataract are extremely prevalent, so the order of the two surgeries and the time interval between them are pivotal choices when planning treatment strategy. The reason for it is that almost any eye surgery is considered a risk factor for long-term trabeculectomy effectiveness. Read More

View Article
January 2018
2 Reads

[Laser treatment of giant iris cyst in the anterior chamber in a child (a clinical observation)].

Vestn Oftalmol 2018 ;134(5):86-91

Helmholtz Moscow Research Institute of Eye Diseases, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.

The article describes a clinical case of a giant post-traumatic iris cyst occupying the anterior chamber in a 3-year-old child successfully treated with laser methods (YAG-laser and diode-pumped laser with doubled frequency). Cyst scarring was achieved with preservation of visual acuity of 1.0. Read More

View Article
January 2018
3 Reads

Ejection fraction in left bundle branch block is disproportionately reduced in relation to amount of myocardial scar.

J Electrocardiol 2018 Nov - Dec;51(6):1071-1076. Epub 2018 Sep 17.

Department of Clinical Physiology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden. Electronic address:

Introduction: The relationship between left ventricular (LV) ejection fraction (EF) and LV myocardial scar can identify potentially reversible causes of LV dysfunction. Left bundle branch block (LBBB) alters the electrical and mechanical activation of the LV. We hypothesized that the relationship between LVEF and scar extent is different in LBBB compared to controls. Read More

View Article
September 2018

Vertical Hyperreflective Lesions on Optical Coherence Tomography in Vitreoretinal Lymphoma.

JAMA Ophthalmol 2018 Nov 29. Epub 2018 Nov 29.

Feinberg School of Medicine, Department of Ophthalmology, Northwestern University, Chicago, Illinois.

Importance: Vitreoretinal lymphoma is a diagnostic challenge and the pathophysiology is still unclear.

Objective: To describe an imaging finding seen on optical coherence tomography (OCT) of patients with vitreoretinal lymphoma.

Design, Setting, And Participants: This case series study was a retrospective medical record review of patients who received a diagnosis of vitreoretinal lymphoma at the Department of Ophthalmology at Northwestern University between July 2014 and January 2016. Read More

View Article
November 2018
4 Reads

Fibrin as a Tissue Adhesive and Scaffold with an Angiogenic Agent (FGF-1) to Enhance Burn Graft Healing In Vivo and Clinically.

J Funct Biomater 2018 Nov 26;9(4). Epub 2018 Nov 26.

Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

There is a need for a strategy to reduce scarring in meshed skin graft healing leading to a better cosmetic result without a significant increase in cost. The strategy in this paper is to increase the closure rate of a meshed skin graft to reduce scarring, which should also decrease the infection rate. Specifically, we used fibrin glue to attach all parts of the graft to the wound bed and added in an angiogenic growth factor and made the fibrin porous to further help the growth of blood vessels from the wound bed into the graft. Read More

View Article
November 2018

Continuity of genetic and environmental influences on clinically assessed major depression from ages 18 to 45.

Psychol Med 2018 Nov 28:1-9. Epub 2018 Nov 28.

Department of Psychiatry,Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University,Richmond, VA,USA.

Background: Studies on the stability of genetic risk for depression have relied on self-reported symptoms rather than diagnoses and/or short follow-up time. Our aim is to determine to what degree genetic and environmental influences on clinically assessed major depressive disorder (MDD) are stable between age 18 and 45.

Methods: A population-based sample of 11 727 twins (6875 women) born between 1967 and 1991 was followed from 2006 to 2015 in health registry data from primary care that included diagnoses provided by treating physicians. Read More

View Article
November 2018
1 Read

Ephrin-A2 affects wound healing and scarring in a murine model of excisional injury.

Burns 2018 Oct 25. Epub 2018 Oct 25.

Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia, Australia; The Institute for Respiratory Health, The University of Western Australia, Nedlands, Western Australia, Australia; The Fiona Wood Foundation, Perth, Western Australia, Australia. Electronic address:

Ephrin ligand/Eph receptor signaling is important in both tissue development and homeostasis. There is increasing evidence that Ephrin/Eph signaling is important in the skin, involved in hair follicle cycling, epidermal differentiation, cutaneous innervation and skin cancer. However, there is currently limited information on the role of Ephrin/Eph signaling in cutaneous wound healing. Read More

View Article
October 2018
1 Read

In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis.

J Nanobiotechnology 2018 Nov 27;16(1):97. Epub 2018 Nov 27.

Department of Ophthalmology, King's College London, Westminster Bridge Road, London, SE1 7EH, UK.

Background: Sustained drug delivery is a large unmet clinical need in glaucoma. Here, we incorporated a Myocardin-Related Transcription Factor/Serum Response Factor inhibitor, CCG-222740, into slow release large unilamellar vesicles derived from the liposomes DOTMA (1,2-di-O-octadecenyl-3-trimethylammonium propane) and DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine), and tested their effects in vitro and in vivo.

Results: The vesicles were spherical particles of around 130 nm and were strongly cationic. Read More

View Article
November 2018
2 Reads

Adipose tissue transplant in recurrent folliculitis decalvans.

Int J Immunopathol Pharmacol 2018 Mar-Dec;32:2058738418814688

Department of Plastic and Reconstructive Surgery, San Gallicano Dermatological Institute IRCCS, Rome, Italy.

Folliculitis decalvans is a rare clinical disorder classified as primary neutrophilic scarring alopecia with a slight preference for the male gender. Here, we report the use of autologous fat transplantation as a source of stem cell therapy for hair re-growth assisted by inflammatory action of the fat itself in a female patient. The patient underwent adipose transplantation in April and September 2017. Read More

View Article
November 2018
10 Reads

Clinical Evaluation of Safety and Efficacy of Fractional Radiofrequency Facial Treatment of Skin Type VI Patients

J Drugs Dermatol 2018 Nov;17(11):1169 - 1172

INTRODUCTION: It has been well established that patients with darker skin types (Fitzpatrick skin types IV-VI) have an increased incidence of thermal induced side effects from laser and radio frequency (RF) treatments. Complications include a higher risk of post-inflammatory hyperpigmentation, hypopigmentation, and scarring, leading to unsatisfactory clinical outcomes. Fractional technologies improve the safety when treating patients with skin of color by treating only fractions of the skin while leaving a healing reservoir of untreated skin that improves the healing process. Read More

View Article
November 2018
3 Reads

The Safety of Laser Skin Resurfacing With the Microablative Carbon Dioxide Laser and Review of the Literature

J Drugs Dermatol 2018 Nov;17(11):1157 - 1162

OBJECTIVE: The aim of this study was to evaluate the incidence of adverse effects following laser skin resurfacing with the microablative carbon dioxide (CO2) laser system (SmartXide DOT; DEKA, Calenzano, Italy). METHODS: A retrospective chart review was performed. Data was collected for DOT laser procedures performed at three clinical centers from 2008-2014. Read More

View Article
November 2018
1 Read

Severe Dry Eye With Combined Mechanisms is Involved in the Ocular Sequelae of SJS/TEN at the Chronic Stage.

Invest Ophthalmol Vis Sci 2018 Nov;59(14):DES80-DES86

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Stevens-Johnson syndrome (SJS), and its more severe variant, toxic epidermal necrolysis (TEN), are life-threatening diseases of the skin and mucous membranes. After the acute-stage damage subsides, serious visual impairment and severe dry eye remains as ocular sequelae. At the acute stage, ocular complications occur in 77% of SJS/TEN patients. Read More

View Article
November 2018
6 Reads

Regressing Conjunctival Nevus in a Child.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):501-503

Liverpool Ocular Oncology Centre, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, England, UK.

Purpose: To report a case exhibiting drastic regression of a conjunctival nevus in a child.

Case Report: Spontaneous regression of conjunctival nevus is uncommon. We report the case of a nine-year-old Caucasian boy presenting a conjunctival-pigmented lesion situated at the plica semilunaris that underwent a significant reduction in size and color over a period of 15 months. Read More

View Article
November 2018
3 Reads