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J Am Acad Dermatol 2022 May 18. Epub 2022 May 18.

Universidade Estadual Paulista - UNESP, Botucatu, São Paulo, Brazil. Electronic address:

Indian J Dermatol Venereol Leprol 2022 Apr 19:1-3. Epub 2022 Apr 19.

Department of Dermatology, Wockhardt Hospitals, Mumbai, Maharashtra, India.

Clin Cosmet Investig Dermatol 2022 10;15:843-849. Epub 2022 May 10.

Department of Dermatology, Peking University First Hospital, Beijing, 100034, People's Republic of China.

Background: Collecting data on hair counts helps dermatologists diagnose hair diseases more accurately. Quantitative trichoscopy analysis and pathologic examination are two common ways to evaluate hair parameters.

Purpose: The study aims to compare the effect of quantitative trichoscopy analysis and pathologic examination in hair counting and quantify the hair density of average Chinese people. Read More

J Am Acad Dermatol 2022 May 16. Epub 2022 May 16.

Massachusetts General Hospital, Department of Dermatology, Boston, MA. Electronic address:

Front Med (Lausanne) 2022 2;9:890206. Epub 2022 May 2.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Syphilitic alopecia (SA), which mimics other types of alopecia, is an uncommon manifestation of secondary syphilis. Trichoscopic features may facilitate its diagnosis. However, studies on SA and its trichoscopic characteristics remain limited. Read More

J Cosmet Dermatol 2022 May 17. Epub 2022 May 17.

University of Health Science Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Biochemistry, 06110, Ankara, Turkey.

Background: There may be an association between increased intestinal permeability and the progression of alopecia areata (AA).

Objective: The present study aimed to investigate the role of intestinal permeability in the etiopathogenesis of AA and its association with the severity of the disease.

Methods: Serum zonulin levels of 70 patients with AA who were not receiving any systemic treatment and of 70 healthy control subjects were measured. Read More

Int J Dermatol 2022 May 17. Epub 2022 May 17.

Section of Dermatology - Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.

Clin Exp Rheumatol 2022 May 10. Epub 2022 May 10.

Department of Rheumatology, National Centre for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Objectives: In this study, we aimed to explore the expression of the Aicardi-Goutières syndrome (AGS) mutant gene SAMHD1 in paediatric-onset systemic lupus erythematosus (pSLE), its correlations with clinical and laboratory parameters, and the relationship between its expression and the type 1 interferon (IFN) signalling pathway.

Methods: Peripheral blood from 98 pSLE patients and 44 gender and age-matched healthy individuals were examined. Gene expression levels of SAMDH1 and interferon-stimulated genes (ISGs; MxA, IRF3 and IRF7) were evaluated using real-time RT-PCR assays. Read More

Acta Derm Venereol 2022 May 17. Epub 2022 May 17.

Dermatology Unit, Hospital Universitario Virgen de las Nieves, Granada.

Int J Dermatol 2022 May 16. Epub 2022 May 16.

Department of Dermatology, Qatif Central Hospital, Qatif Health Network, First Health Cluster, Qatif, Saudi Arabia.

J Cutan Med Surg 2022 May 15:12034754221099667. Epub 2022 May 15.

8167 Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Front Oncol 2022 27;12:878336. Epub 2022 Apr 27.

The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin, Ireland.

Cutaneous melanoma can be a most challenging neoplasm of high lethality, in part due to its extreme heterogeneity and characteristic aggressive and invasive nature. Indeed, its moniker 'the great masquerader' reflects that not all melanomas are created equal in terms of their originating cellular contexts, but also that melanoma cells in the malignant tumor can adopt a wide range of different cell states and variable organotropism. In this review, we focus on the early phases of melanomagenesis by discussing how the originating pigment cell of the melanocyte lineage can be influenced to embark on a wide range of tumor fates with distinctive microanatomical pathways. Read More

Comput Math Methods Med 2022 6;2022:6431852. Epub 2022 May 6.

Cancer Center, The First People's Hospital of Huaihua City, Huaihua, 418000 Hunan, China.

To analyze the effectiveness and safety of zoledronic acid combined with chemotherapy for lung cancer spinal metastases, 96 patients with lung cancer spinal metastases were averagely classified into the experimental group (gemcitabine, cisplatin, and zoledronic acid) and the control group (gemcitabine and cisplatin). An optimized noise variance estimation algorithm (OMAPB) was proposed based on the maximum a posteriori Bayesian method (MAPB), and the algorithm was applied to the patient's computed tomography (CT) scan. The results indicated that in terms of curative effect, the number of complete remission (CR), partial remission (PR) cases, effective rate, and clinical benefit rate of the test group was significantly higher than those of the control group. Read More

JAAD Case Rep 2022 May 7. Epub 2022 May 7.

UCF Health, Department of Dermatology.

JAAD Case Rep 2022 May 7. Epub 2022 May 7.

University of California, Irvine, Department of Dermatology, Irvine, CA, USA.

Actas Dermosifiliogr 2022 May 12. Epub 2022 May 12.

Dermatology Department, Trichology Unit, Ramon y Cajal University Hospital, University of Alcala, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain, Trichology and Hair Transplantation Unit, Grupo Pedro Jaen Clinic, Madrid, Spain.

Skin Pharmacol Physiol 2022 May 13. Epub 2022 May 13.

Psychosocial stress stimulates the secretion of glucocorticoids (GCs), which are stress-related neurohormones. GCs are secreted from hair follicles and promote hair follicle regression by inducing cellular apoptosis. Moreover, the androgen receptor (AR) is abundant in the balding scalp and androgens suppress hair growth by binding to androgen receptor (AR) in androgenetic alopecia (AGA). Read More

Breast 2022 Apr 30;64:50-55. Epub 2022 Apr 30.

Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria.

Dermatol Ther 2022 May 15:e15584. Epub 2022 May 15.

Department of Dermatology, Warren Alpert Medical School at Brown University, Providence, Rhode Island, USA.

Background: Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory cutaneous disorder typically affecting sun-damaged skin of mature individuals. Clinical features of EPDS include sterile pustules and chronic crusted erosions that can be hyperkeratotic and lead to scarring alopecia, atrophy, and telangiectasia. While the condition occurs on sun-damaged skin, a relationship with non-melanoma skin cancer (NMSC) has not been investigated. Read More

Psychiatry Res 2022 May 10;313:114620. Epub 2022 May 10.

Department of Dermatology and Venereology, National Medical College, Birgunj-15, Parsa 44300, Nepal.

We aimed to systematically review published cases of alopecia (hair loss) associated with selective serotonin reuptake inhibitors (SSRIs). Four electronic databases were searched up to November 16, 2021. Thirty-eight publications describing 71 patients with a total of 81 episodes of alopecia met inclusion criteria. Read More

J Clin Med 2022 Apr 25;11(9). Epub 2022 Apr 25.

Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Korea.

Systemic lupus erythematosus (SLE) is a heterogeneous disorder with diverse clinical manifestations. This study classified patients by combining laboratory values at SLE diagnosis via hierarchical cluster analysis. Linear discriminant analysis was performed to construct a model for predicting clusters. Read More

Br J Dermatol 2022 May 13. Epub 2022 May 13.

Department of Medicine, University of Nottingham, Nottingham, UK.

J Fam Pract 2022 Apr;71(3):E13-E14

Family and Community Medicine, Dermatology and Cutaneous Surgery, University of Texas Health, San Antonio.

THE PRESENTATION A Early central centrifugal cicatricial alopecia with a small central patch of hair loss in a 45-year-old Black woman. B Late central centrifugal cicatricial alopecia with a large central patch of hair loss in a 43-year-old Black woman. Read More

J Am Acad Dermatol 2022 May 9. Epub 2022 May 9.

Department of Dermatology, Columbia University Irving Medical Center, New York, NY 10032. Electronic address:

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Jan;47(1):72-78

First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

Objectives: The pathogenesis of androgenetic alopecia (AGA) is related to the level of androgen and its metabolic pathways. The binding of androgen and androgen receptor (AR) depends on the assistance of heat shock protein 27 (HSP27). HSP27 combined with microRNAs (miR)-1 can regulate AR levels. Read More

Acta Parasitol 2022 May 10. Epub 2022 May 10.

Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.

Purpose: Dermatophagoides spp. (Acariformes; Pyroglyphidae), house dust-mite well known as the causative agent of atopic hypersensitivity and allergy could potentially cause severe dermatitis. Herein we report an uncommon case of scalp dermatitis associated with the presence of Dermatophagoides spp. Read More

J Dermatol 2022 May 10. Epub 2022 May 10.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Clin Epidemiol 2022 3;14:641-652. Epub 2022 May 3.

Boston Collaborative Drug Surveillance Program, Lexington, MA, USA.

Background: Assessments of strengths and limitations of new data sources are critical for making decisions about suitability for specific research questions. For some studies, it is necessary to capture a drug's indication for use.

Objective: To assess the presence of indications for prescription use in Clinical Practice Research Datalink (CPRD) Aurum (January 1988-June 2021) by describing the proportion of men in CPRD Aurum who had a recorded indication for use of prescriptions for 5-alpha reductase inhibitors (5-ARI), alpha blockers (AB), or tadalafil, which have multiple indications. Read More

Skinmed 2022 30;20(2):136-138. Epub 2022 Apr 30.

Division of Dermatology, Faculty of Medicine, Lebanese University, Beirut, Lebanon;

A 52-year-old woman with a 10-pack-year smoking history presented with serious hair loss. She had a 10-year history of Crohn's disease associated with arthritis, for which she had been taking adalimumab. After 2 months of this treatment, she developed pustular lesions on her palms, soles, and scalp. Read More

Skinmed 2022 30;20(2):97-104. Epub 2022 Apr 30.

Departments of Dermatology & Venereology, Faculty of Medicine, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia.

Autologous serum is a component taken from patient's blood after centrifugation to be used for the same patient. Lately, growth factors (GF) found in platelet-rich plasma (PRP) has been widely used as an alternative therapeutic modality in various medical fields. The benefits of using autologous serum effectively include reduced risk of hypersensitivity or allergic reactions as well as the reduced risk of transmission of infectious diseases; however, in practice, the availability of products with GF is still limited. Read More