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    Trichoscopic diagnosis of cutaneous Pelodera strongyloides infestation in a dog.
    Vet Dermatol 2017 Mar 27. Epub 2017 Mar 27.
    Servizi Dermatologici Veterinari, Strada Bedale della Ressia 2, I-12016, Peveragno (CN), Italy.
    Background: Pelodera strongyloides infestation has rarely been reported in dogs. It is a saprophytic free-living nematode, found in moist decaying organic matter, whose L3 larval stages occasionally can invade the skin of dogs and humans. Larvae penetrate the follicular infundibula causing an erythematous and pruritic dermatitis. Read More

    Lichenoid folliculitis, a unifying concept.
    J Cutan Pathol 2017 Mar 26. Epub 2017 Mar 26.
    Department of Dermatology, Uniformed Services University of the Health Sciences, Los Angeles, California and Bethesda, Maryland.
    Skin diseases presenting with keratotic papules, atrophy, cicatricial alopecia, and/or "lichenoid" histopathologic changes have been described under at least 30 names. This family of diseases contains two subgroups, largely based on clinical features: keratosis pilaris atrophicans (KPA; including keratosis pilaris atrophicans faciei/ulerythema ophryogenes, atrophoderma vermiculata , and keratosis follicularis spinulosa decalvans); and the lichen planopilaris (LPP) subgroup (including LPP, frontal fibrosing alopecia, Graham-Little-Piccardi-Lassueur Syndrome, and fibrosing alopecia in a pattern distribution). An interface dermatitis with lichenoid inflammation is characteristic of the LPP group of disorders, but the literature provides scant information about the histopathology of the KPA group. Read More

    Reversible Alopecia with Localized Scalp Necrosis After Accidental Embolization of the Parietal Artery with Hyaluronic Acid.
    Aesthetic Plast Surg 2017 Mar 24. Epub 2017 Mar 24.
    Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 127, Changle West Road, Xi'an, 710032, Shaanxi, China.
    Hyaluronic acid (HA) filler injection is widely used for soft-tissue augmentation. Complications associated with HA filling are not uncommon; however, HA-induced alopecia is a rarely reported complication that could result in severe secondary psychological trauma. The etiology, clinical traits, treatment strategies, outcomes, and possible reversibility of HA-induced alopecia have not been characterized. Read More

    TNF-inhibitor associated psoriatic alopecia: diagnostic utility of sebaceous lobule atrophy.
    J Cutan Pathol 2017 Mar 23. Epub 2017 Mar 23.
    Depts of Pathology, Virginia Mason Medical Center, Seattle, WA.
    Background: The increasingly successful and widespread use of TNF inhibitors (TNFi) to treat autoimmune and inflammatory conditions has also been accompanied by adverse reactions, both systemic and cutaneous. Psoriasiform cutaneous rashes are well described. Recently, TNF inhibitor associated psoriatic alopecia (TiAPA) is being more frequently reported. Read More

    TNF inhibitor induced alopecia: an unusual form of psoriasiform alopecia that breaks the Renbök mold.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    University of Wisconsin, Departments of Internal Medicine and Dermatology, Madison, Wisconsin.
    TNF-α-inhibitors are known to induce skin adverseeffects including psoriasis and alopecia areata. Here, wedescribe a unique pattern of hair loss that has psoriaticand alopecia areata-like features. Diagnosis requiresclinical-pathologic correlation and is supportedby increased catagen/telogen hairs, psoriasiformepidermal hyperplasia, perifollicular lymphocyticinfiltrate, and the presence of eosinophils and plasmacells. Read More

    Ichthyosis follicularis with alopecia and photophobia syndrome (IFAP): A Case Report.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    Pediatric Dermatology Section, Hospital Ramos Mejía. Buenos Aires, Argentina.
    IFAP syndrome is a rare autosomal recessive X-linked disease characterized by the triad of alopecia universalis, severe photophobia, and follicular ichthyosis. It is caused by loss of function of the gene MBTPS2. Its severity varies and there are only a few reports in the literature. Read More

    Cynomolgus monkeys are successfully and persistently infected with hepatitis E virus genotype 3 (HEV-3) after long-term immunosuppressive therapy.
    PLoS One 2017 22;12(3):e0174070. Epub 2017 Mar 22.
    Laboratório de Desenvolvimento Tecnológico em Virologia, Oswaldo Cruz, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
    Epidemiological studies found that hepatitis E virus genotype 3 (HEV-3) infection was associated with chronic hepatitis and cirrhosis in immunocompromised patients. Our study aimed to investigate the relationship between the host immunosuppressive status and the occurrence of HEV-related chronic hepatitis. Here we describe a successful experimental study, using cynomolgus monkeys previously treated with tacrolimus, a potent calcineurin inhibitor immunosuppressant, and infected with a Brazilian HEV-3 strain isolated from naturally infected pigs. Read More

    Novel Approach to Treating Androgenetic Alopecia in Females With Photobiomodulation (Low-Level Laser Therapy).
    Dermatol Surg 2017 Mar 21. Epub 2017 Mar 21.
    *Scottsdale Institute For Cosmetic Dermatology, Scottsdale, Arizona; †Capillus, Miami, Florida.
    Background: Photobiomodulation, also referred to as low-level laser therapy (LLLT), has been studied and used for (among other diseases) the promotion of hair regrowth.

    Objective/materials And Methods/results: A clinical study was developed to define the physiologic effects that occur when the human hair follicle and surrounding tissue structures are exposed to laser light using a novel device that is fitted with an array of laser diode sources operating at 650 nm and placed inside a sports cap to promote discretion while in use. The study demonstrates that low-level laser treatment of the scalp every other day for 17 weeks using the HANDI-DOME LASER device is a safe and effective treatment for androgenetic alopecia in healthy females between the ages of 18 to 60 with Fitzpatrick skin Types I to IV and Ludwig-Savin Baldness Scale I-2 to II-2 baldness patterns. Read More

    [Complications of supratemporalis approach with scalp coronal incision for orbital-zygomatic fracture].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2017 Feb;35(1):73-76
    State Key Laboratory of Oral Diseases, Dept. of Traumatic and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
    Objective: This study aimed to examine the complications of supratemporalis approach with scalp coronal incision for the treatment of orbital-zygomatic fractures.

    Methods: A total of 206 patients with orbital-zygomatic fractures were treated with scalp coronal incision through the supratemporalis approach. The effects and complications of the treatment were analyzed. Read More

    Can mindfulness-based interventions improve the quality of life of patients with moderate/severe alopecia areata? A prospective pilot study.
    J Am Acad Dermatol 2017 Apr;76(4):757-759
    Section of Dermatology, Department of Health Sciences, University of Genoa, Genoa, Italy; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Azienda Ospedaliera Universitaria (AOU) San Martino-Istituto Nazionale per La Ricerca sul Cancro (IST) Genoa, Italy.

    Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles.
    Pharmacol Rep 2017 Jan 25;69(3):485-491. Epub 2017 Jan 25.
    Licensing & Business Development, Taisho Pharmaceutical Co., Ltd., Toshima-ku, Tokyo, Japan.
    Background: Androgenic alopecia (AGA) occurs as a result of the contraction of the anagen phase because of the action of androgens on hair follicles. TGF-β production from dermal papillae is enhanced by androgens, and growth inhibition of hair-follicle cells is induced by TGF-β, and the hair cycle progresses from the anagen phase to the catagen phase. We investigated both the in vitro and in vivo potency of the newly identified ALK5 inhibitor TP0427736 {6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole}. Read More

    Chemotherapy-induced irreversible alopecia in early breast cancer patients.
    Breast Cancer Res Treat 2017 Mar 21. Epub 2017 Mar 21.
    Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, Korea.
    Purpose: The purpose of this work is to determine the prevalence of chemotherapy-induced irreversible alopecia (CIIA), which is defined as an alopecia that exists at least 6 months after completion of chemotherapy and factors affecting CIIA in early breast cancer patients.

    Methods: We performed a cross-sectional study. We retrospectively identified breast cancer patients who had received AC (Adriamycin, Cyclophosphamide) or AC-T (AC followed by Taxane) as neoadjuvant or adjuvant chemotherapy. Read More

    Two cases of alopecia areata treated with ruxolitinib: a discussion of ideal dosing and laboratory monitoring.
    Int J Dermatol 2017 Mar 21. Epub 2017 Mar 21.
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Background: Alopecia areata is a relatively common condition affecting patients seen in community dermatology clinics. A 2014 study implicated the JAK1/JAK2 inhibitor, ruxolitinib in short-term treatment of alopecia, however little information exists about the long-term use in otherwise healthy individuals in the community setting.

    Methods: A patient with chronic alopecia areata and a patient with acute onset alopecia universalis were treated with oral ruxolitinib for over a year. Read More

    Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation.
    Arch Dermatol Res 2017 Mar 20. Epub 2017 Mar 20.
    Biospectrum Life Science Institute, Eines Platz 11th FL, #442-13 Sangdeawon-dong, Seongnam-si, Gyeonggi-do, Republic of Korea.
    Hair loss known as alopecia is caused by abnormal hair follicle cycling including shortening of the anagen (growth) phase and changing of hair follicle morphology with miniaturization. In accordance with the life extension, the quality of life is considered to be a most important thing. The yearning for healthy and beautiful hair and low self esteem due to hair loss had negative influence on the quality of life with psychosocial maladjustment. Read More

    Lupus erythematosus tumidus of the scalp masquerading as alopecia areata.
    Cutis 2017 Feb;99(2):E22-E24
    Dermatology Residency Program, San Antonio Uniformed Services Health Education Consortium, Texas, USA.
    Lupus erythematosus tumidus (LET) is a unique subset of chronic cutaneous lupus erythematosus (CCLE) that generally presents as urticarialike papules and plaques with induration and erythema on the face, trunk, and upper extremities. Lesions rarely present on the scalp or below the waist. We report a unique case of LET on the scalp of a woman that presented clinically as alopecia areata. Read More

    Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood.
    Bone Marrow Transplant 2017 Mar 20. Epub 2017 Mar 20.
    Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands.
    Permanent alopecia after haematopoietic stem cell transplantation (HSCT) is distressing and few studies have investigated this late effect. The aim of the study was to assess the percentage of patients with alopecia and investigate risk factors for alopecia. Patients who underwent allogeneic HSCT before age 19 years, from January 1990 to January 2013, who were at least 2 years after transplant and in follow-up in our clinic were included. Read More

    Clinical and Laboratory Characteristics of a Tinea Capitis Outbreak Among Novice Buddhist Monks.
    Pediatr Dermatol 2017 Mar 20. Epub 2017 Mar 20.
    Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Sixty novice Buddhist monks with tinea capitis confirmed according to clinical presentation and mycological laboratory finding were included in this study. Mixed-type clinical presentation was observed in approximately half of all cases, together with scarring alopecia (95%) and superficial fungal skin infection at locations other than the scalp (43.3%). Read More

    Scalp Cooling: A Literature Review of Efficacy, Safety, and Tolerability for Chemotherapy-Induced Alopecia
.
    Clin J Oncol Nurs 2017 Apr;21(2):226-233
    Memorial Sloan Kettering Cancer Center.
    Background: More than 75% of patients with cancer cite alopecia as the most feared side effect of treatment, with as many as 10% considering treatment refusal. Despite wide acceptance in other countries, scalp cooling to reduce chemotherapy-induced alopecia (CIA) has been uncommon in the United States because of longstanding concerns of scalp metastases and a lack of reliable efficacy data. 
. Read More

    Hereditary vitamin D-resistant rickets in Lebanese patients: the p.R391S and p.H397P variants have different phenotypes.
    J Pediatr Endocrinol Metab 2017 Mar 16. Epub 2017 Mar 16.
    Background: Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder caused by mutations in the vitamin D receptor (VDR) gene. Variable phenotypes have been associated with these mutations, and some of these were linked to the effects they have on the interacting partners of VDR, mainly the retinoic X receptor (RXR).

    Methods: We examined four patients with HVDRR from three unrelated Lebanese families. Read More

    Response to "Frontal fibrosing alopecia in men-an association with facial moisturisers and sunscreen".
    Br J Dermatol 2017 Mar 16. Epub 2017 Mar 16.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.
    We applaud Debroy-Kidambi et al for repeating their questionnaire study in male patients to determine possible environmental exposures that could be contributing to the increasing incidence of frontal fibrosing alopecia (FFA). In fact, in our own clinic we have noted that patients are often as interested in the possible causes of this condition as they are in available treatment methods. The discrepancy in facial moisturizer use between men with FFA compared to controls (94% versus 32%, p<0. Read More

    Lichen planopilaris-like eruption during treatment with tyrosine kinase inhibitor nilotinib.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):45-47
    Hospital do Servidor Público Estadual de São Paulo (HSPE) - São Paulo (SP), Brazil.
    Tyrosine kinase inhibitors are effective as a target therapy for malignant neoplasms. Imatinib was the first tyrosine kinase inhibitor used. After its introduction, several other drugs have appeared with a similar mechanism of action, but less prone to causing resistance. Read More

    Frontal fibrosing alopecia in association with Sjögren's syndrome: more than a simple coincidence.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):14-16
    Hospital do Servidor Público Estadual do Estado de São Paulo (HSPE) - São Paulo (SP), Brazil.
    Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered to be a clinical variant of lichen planopilaris. It predominantly occurs in postmenopausal women and has a slowly progressive course. It was first described by Kossard in 1994. Read More

    Alopecia areata.
    Nat Rev Dis Primers 2017 Mar 16;3:17011. Epub 2017 Mar 16.
    Department of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
    Alopecia areata is an autoimmune disorder characterized by transient, non-scarring hair loss and preservation of the hair follicle. Hair loss can take many forms ranging from loss in well-defined patches to diffuse or total hair loss, which can affect all hair-bearing sites. Patchy alopecia areata affecting the scalp is the most common type. Read More

    Monilethrix in monozygotic twins with very rare mutation in KRT 86 gene.
    J Eur Acad Dermatol Venereol 2017 Mar 16. Epub 2017 Mar 16.
    Department of Dermatology, Allergology and Venerology Medical University of Gdansk, Poland.
    Monilethrix is a heretitary disorder, characterized by abnormal hair shafts with nodes and narrow internodes [1], typically caused by autosomal dominant mutations in type II hair keratin genes KRT 81, KRT 83 and KRT 86 [2-8]. Rarely, autosomal recessive mutation in desmoglein 4 gene may be responsible for the disease [9,10]. Among affected family members, symptoms may vary from almost normal scalp to alopecia, moreover the severity of the disease may change during patient life. Read More

    "X" Marks the Spot: An Injection Technique for Alopecia Areata.
    Pediatr Dermatol 2017 Mar;34(2):214-215
    Department of Dermatology, Henry Ford Health System, Detroit, Michigan.
    Children with alopecia areata often have multiple patches of hair loss. When administering intralesional steroid injections, it can be difficult to monitor which areas have already been treated. Additionally, patients and their parents may worry that we did not treat all of the affected areas. Read More

    Plated-rich plasma for androgenetic alopecia: Does it work? Evidence from meta analysis.
    J Cosmet Dermatol 2017 Mar 13. Epub 2017 Mar 13.
    Department of Orthopaedics and Traumatology, Turku University Hospital and the University of Turku, Turku, Finland.
    Introduction: The use of plated-rich plasma (PRP) has increased among different surgical specialities for the treatment of various conditions. Androgenetic alopecia is a common condition, with severe attendant psychosocial implications. PRP injections for hair restoration have become a popular practice among plastic surgeons. Read More

    Dutasteride in androgenetic alopecia: An update.
    Curr Clin Pharmacol 2017 Mar 10. Epub 2017 Mar 10.
    Department of Dermatology, STDs and Leprosy, Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University (AMU), Aligarh, India.
    Background: Androgenetic alopecia is a common condition characterized by thinning of scalp hair. Conversion of testosterone to dihydrotestosterone, a more potent androgen, by the enzyme 5-a-reductase is responsible for underlying pathogenesis. Dutasteride, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type-1 and type-2 isoenzymes of 5-alpha-reductase. Read More

    Submental Alopecia at Deoxycholic Acid Injection Site.
    Dermatol Surg 2017 Mar 13. Epub 2017 Mar 13.
    Dermatology, Hackensack University Medical Center - Palisades, North Bergen, New Jersey Dermatology, Escola de Medicina/BWS Consultoria Médica e Educacional LTDA, Fundação Técnico- Educacional Souza Marques, Rio de Janeiro, Brazil Dermatology, Mount Sinai School of Medicine, New York, New York.

    [Cardiooncology: Current Aspects of Prevention of Anthracycline Toxicity].
    Kardiologiia 2016 Dec;56(12):72-79
    A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
    Anthracyclines including doxorubicin, epirubicin, daunorubicin, aclarubicin are extensively used as chemotherapeutic agents for treatment of hematological and other malignancies. In cancer therapy anthracyclines are often used in combinations with other chemotherapeutic drugs and agents for molecularly targeted therapy. Anthracyclines are effective and powerful antineoplastic drugs with wide spectrum of application but active use of preparations of this group is limited because of such side effects as cardiotoxicity, myelotoxicity, thromboembolism, alopecia, etc. Read More

    Kynurenic acid downregulates IL-17/1L-23 axis in vitro.
    Mol Cell Biochem 2017 Mar 11. Epub 2017 Mar 11.
    BC Professional Firefighters' Burn & Wound Healing Research Laboratory, Department of Surgery, University of British Columbia, 4550 ICORD, 818 10th Avenue West, Vancouver, BC, V5Z 1M9, Canada.
    Exploring the function of interleukin (IL) 17 and related cytokine interactions have been proven useful toward understanding the role of inflammation in autoimmune diseases. Production of the inflammatory cytokine IL-23 by dendritic cells (DC's) has been shown to promote IL-17 expression by Th17 cells. It is well established that Th17 cells play an important role in several autoimmune diseases including psoriasis and alopecia. Read More

    Necrotizing Polyarteritis Nodosa-like Vasculitis in a Child with Systemic Lupus Erythematosus.
    Indian Pediatr 2017 Feb;54(2):139-144
    Departments of Pediatrics and *Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    A 10-year-old child presented with prolonged fever, lymphadenopathy, weight loss, oral ulcers, alopecia and parotitis. She later developed arterial thrombosis, poly-serositis, nephritis, myocarditis, sacro-ilitis, autoimmune hemolytic anemia and refractory thrombocytopenia. Though anti-dsDNA was negative, she was diagnosed to have systemic lupus erythematosus (SLE). Read More

    Permanent alopecia in patients with breast cancer after taxane chemotherapy and adjuvant hormonal therapy: Clinicopathologic findings in a cohort of 10 patients.
    J Am Acad Dermatol 2017 Mar 8. Epub 2017 Mar 8.
    St John's Institute of Dermatology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom; Department of Dermatopathology, St John's Institute of Dermatology, NHS Foundation Trust, Guy's and St Thomas' Hospital, London, United Kingdom. Electronic address:
    Background: Anagen effluvium with reversible scalp alopecia is a known side effect of chemotherapy. However, there are an increasing number of reports in the literature documenting permanent alopecia in patients treated with taxanes.

    Objective: We sought to describe the clinicopathologic features in breast cancer patients who underwent treatment with taxanes and adjuvant hormonal chemotherapy. Read More

    [Physiology of the scalp].
    Hautarzt 2017 Mar 9. Epub 2017 Mar 9.
    Klinik für Anaesthesiologie und Operative Intensivmedizin, Medizinische Fakultät Mannheim, Ruprecht-Karls-Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.
    Background: Human scalp reveals a remarkable difference to hairy skin of other body regions. The structure of the scalp offers effective protection against water loss and contributes to thermoregulation due to significant vascularization. The scalp is innervated by the trigeminus nerve. Read More

    Platelet rich plasma for treatment of non-scarring hair loss: systematic review of literature.
    J Dermatolog Treat 2017 Mar 23:1-8. Epub 2017 Mar 23.
    a Center for Research and Training in Skin diseases and Leprosy, Tehran University of Medical Science , Tehran , Iran.
    Background: Although there are many studies showing the role of platelet rich plasma (PRP) in bone grafts, teeth osteosynthesis, and wound healing, there have been little peer reviewed studies about the safety and efficacy of PRP application in the treatment of hair loss.

    Materials And Methods: In this systematic review, we searched Ovid Medline, Scopus and Web of Knowledge till November 2015 for human studies evaluating the efficacy of PRP for the treatment of non-cicatricial alopecia.

    Results: Among 704 articles retrieved in first search, 18 articles matched our inclusion criteria, 14 for androgenic alopecia and four for alopecia areata. Read More

    Infundibular protein and RNA-microarray analyses from affected and clinically non-affected scalp in male androgenetic alopecia patients.
    Exp Dermatol 2017 Mar 7. Epub 2017 Mar 7.
    Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

    Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles.
    Sci Rep 2017 Mar 7;7:44127. Epub 2017 Mar 7.
    Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea.
    Alopecia areata (AA), a chronic, relapsing, hair-loss disorder, is considered to be a T cell-mediated autoimmune disease. It affects approximately 1.7% of the population, but its precise pathogenesis remains to be elucidated. Read More

    Bimatoprost for the treatment of eyelash, eyebrow and scalp alopecia.
    Expert Opin Investig Drugs 2017 Apr 16;26(4):515-522. Epub 2017 Mar 16.
    b Department of Dermatology and Cutaneous Surgery , University of Miami, Miller School of Medicine , Miami , FL , USA.
    Introduction: Alopecia is a common condition observed among people of all ages. It is a disorder that can involve only the scalp as observed in androgenetic alopecia or scalp and body as in alopecia areata or patients under chemotherapy treatment. There are several treatment options with different safety and efficacy outcomes. Read More

    A genomic approach to susceptibility and pathogenesis leads to identifying potential novel therapeutic targets in androgenetic alopecia.
    Genomics 2017 Mar 2. Epub 2017 Mar 2.
    Department of Dermatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 6078 Clinical and Translational Research Center, 875 Ellicott Street, Buffalo, NY 14203, United States. Electronic address:
    We studied genome-wide gene expression from bald and haired scalp of individuals to evaluate pathogenic mechanisms underlying the development and progression of androgenetic alopecia (AGA). Unbiased analyses revealed a "bald pathology" based signature. Ontology enrichment analyses of the differentially expressed genes (DEGs) underscored apoptosis, cell proliferation, perturbed neurological pathways, and WNT signaling as central drivers of the hair loss process. Read More

    Properties of skin stem cells and their potential clinical applications in modern dermatology.
    Eur J Dermatol 2017 Mar 11. Epub 2017 Mar 11.
    Nicolaus Copernicus University in Toruń, Faculty of Medicine, Chair of Dermatology, Sexually Transmitted Diseases, Immunodermatology, Toruń, Poland.
    Stem cells play an important role in medical science, and scientists are investing large sums in order to perform sophisticated studies designed to establish potential clinical applications of stem cells. Growing experience has enabled researchers to determine the precise nature of stem cell division. Although the properties of this particular population of cells have been known and used for some time, mainly with regards to bone marrow-derived mesenchymal stem cell transplantation, we now face a significant challenge in implementing the practical use of skin-derived precursors, making it possible to avoid the necessity for patients to undergo invasive procedures in order to obtain stem cells from bone marrow. Read More

    Alexithymia in different dermatologic patients.
    Asian J Psychiatr 2017 Feb 12;25:42-45. Epub 2016 Oct 12.
    Department of Industrial Management, University of Tehran, Tehran, Iran.
    Alexithymia is a personality trait characterized by difficulties in differentiating and describing feelings. Research indicates that alexithymia can be considered as a possible risk factor for a variety of medical conditions. The purpose of our study was to compare and assess the prevalence of alexithymia in patients with psoriasis, alopecia areata, vitiligo and acne vulgaris. Read More

    Hair growth cycle is arrested in SCD1-deficiency by impaired Wnt3a-palmitoleoylation and retrieved by artificial lipid barrier.
    J Invest Dermatol 2017 Mar 1. Epub 2017 Mar 1.
    Laboratory of Molecular Neurosciences, Institute of Biochemistry, University of Cologne, 50931 Cologne, Germany; CMMC (Center of Molecular Medicine), University of Cologne, 50931 Cologne, Germany.
    Stearoyl-CoA desaturase 1 (SCD1) is the dominant member of the SCD-isozyme family, regarded as a major regulator of lipid and energy metabolism in liver and adipose tissue. SCD1-deficiency impairs the desaturation of de novo-synthesized palmitoyl- and stearoyl-CoA to palmitoleoyl- and oleoyl- CoA. Scd1-/- mice develop metabolic waste syndrome and skin lesions: epidermal barrier disruption, alopecia and degeneration of sebaceous glands. Read More

    [Frontal fibrosing alopecia: A prospective study of 20 cases].
    Ann Dermatol Venereol 2017 Feb 28. Epub 2017 Feb 28.
    Centre d'anatomopathologie Hassane, Rabat, Maroc.
    Background: Frontal fibrosing alopecia (FFA) is a variant of lichen planopilaris predominantly affecting postmenopausal women. We report a series of 20 cases of FFA and describe the epidemiological, clinical, dermoscopic features and progress under treatment.

    Patients And Methods: This was a prospective study conducted over a period of 16 months in patients seen at the dermatology department of the Hassan II University in Fez, Morocco. Read More

    Adverse drug reactions due to cancer chemotherapy in a tertiary care teaching hospital.
    Ther Adv Drug Saf 2017 Feb 10;8(2):61-66. Epub 2016 Oct 10.
    North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, India.
    Background: An adverse drug reaction (ADR) is defined by World Health Organization (WHO) as 'Any response to a drug which is noxious, unintended and occurs at doses used in man for prophylaxis, diagnosis or therapy'. ADRs associated with cancer chemotherapy warrant analysis on their severity and preventability. The outcome would create awareness among health care providers and prevent their recurrence. Read More

    Female sexual dysfunction in androgenetic alopecia: Case-control study.
    Can Urol Assoc J 2016 Jul-Aug;10(7-8):E251-E256. Epub 2016 Jul 12.
    Department of Urology, Haseki Training and Research Hospital, Istanbul, Turkey.
    Introduction: We sought to evaluate the association of female sexual dysfunction (FSD) with androgenetic alopecia (AGA) and metabolic syndrome (MetS) in premenopausal women.

    Methods: From December 2013 to June 2015, we performed a case-control, prospective study of 115 patients with AGA and 97 age-matched control patients without AGA from among premenopausal women who visited dermatology clinics of the two reference hospitals. Comprehensive history, anthropometric measurements, and questionnaire administration were performed for each of the total of 212 women. Read More

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