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    Nodular-cystic eruption in course of sorafenib administration for hepatocarcinoma: An unconventional skin reaction requiring unconventional treatment.
    Int J Immunopathol Pharmacol 2017 Aug 1:394632017727618. Epub 2017 Aug 1.
    1 Department of Clinical and Experimental Medicine, University Hospital "G. Martino," University of Messina, Messina, Italy.
    Sorafenib is a multitargeted kinase inhibitor currently used in the treatment of advanced hepatocellular carcinoma (HCC). It is associated with a significant risk of skin toxicity, which nevertheless represents a clinical marker of good response to treatment. Hand-and-foot skin reaction, alopecia, mucositis, xerosis, skin discoloration, and nail involvement occur frequently in course of therapy. Read More

    A syndromic extreme insulin resistance caused by biallelic POC1A mutations in exon 10.
    Eur J Endocrinol 2017 Aug 17. Epub 2017 Aug 17.
    A Brusco, Medical Sciences, University of Torino, Torino, 10126, Italy
    POC1A encodes a protein with a role in centriole assembly and stability, and in ciliogenesis. Biallelic loss of function mutations affecting POC1A cause SOFT syndrome, an ultra-rare condition characterized by short stature, onychodysplasia, facial dysmorphism and hypotrichosis. Using exome sequencing, we identified a homozygous frameshift mutation (c. Read More

    Elastic Staining in Differentiating Between Follicular Streamers and Follicular Scars in Horizontal Scalp Biopsy Sections.
    Am J Dermatopathol 2017 Aug 9. Epub 2017 Aug 9.
    Departments of *Pathology, and †Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; and ‡Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
    Background: Accurate identification of follicular streamers versus follicular scars on horizontal scalp biopsy sections is important to differentiate between cicatricial and noncicatricial alopecias. However, distinguishing between them can be difficult especially in nonoptimal specimens. The utility of elastic Verhoeff-Van Gieson (EVG) stain in cicatricial alopecias has been described on vertical sections, but its evaluation on horizontal sections has not been performed. Read More

    Ectropion Improvement with Topical Tazarotene in Children with Lamellar Ichthyosis.
    Pediatr Dermatol 2017 Aug 17. Epub 2017 Aug 17.
    Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.
    Background/objectives: Lamellar ichthyosis (LI) is a well-described phenotypic subtype of autosomal recessive congenital ichthyosis (ARCI). The condition typically presents at birth with collodion membrane and leads to thick, plate-like scaling of the skin throughout the body, alopecia, and prominent ocular manifestations. Ocular complications include bilateral cicatricial ectropion and lagophthalmos. Read More

    Platelet-rich plasma-an 'Elixir' for treatment of alopecia: personal experience on 117 patients with review of literature.
    Stem Cell Investig 2017 18;4:64. Epub 2017 Jul 18.
    Department of Dermatology and Aesthetic Surgery, Aura Skin Institute, Chandigarh, India.
    Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery and dermatology. PRP is a simple, cost-effective and feasible treatment option with high patient satisfaction for hair loss and can be regarded as a valuable adjuvant treatment modality for androgenic alopecia and other types of non-scarring alopecias. Authors have proposed a hair model termed "Golden anchorage with 'molecular locking' of ectodermal and mesenchymal components for survival and integrity of hair follicle (HF)" in this article. Read More

    Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice.
    Cell Rep 2017 Aug;20(7):1513-1524
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan; Japan Agency for Medical Research and Development, CREST, Chiyoda-ku, Tokyo 100-0004, Japan. Electronic address:
    Metabolism by the gut microbiota affects host physiology beyond the gastrointestinal tract. Here, we find that antibiotic-induced dysbiosis, in particular, overgrowth of Lactobacillus murinus (L. murinus), impaired gut metabolic function and led to the development of alopecia. Read More

    Adsorption Properties of Doxorubicin Hydrochloride onto Graphene Oxide: Equilibrium, Kinetic and Thermodynamic Studies.
    Materials (Basel) 2013 May 15;6(5):2026-2042. Epub 2013 May 15.
    Department of Hematology, the Affiliated Hospital of medical College, 16 Jiangsu Road, Qingdao, Shandong 266003, China.
    Doxorubicin hydrochloride (DOX) is an effective anticancer agent for leukemia chemotherapy, although its clinical use has been limited because of its side effects such as cardiotoxicity, alopecia, vomiting, and leucopenia. Attention has been focussed on developing new drug carriers with high adsorption capacity and rapid adsorption rate in order to minimize the side effects of DOX. Graphene oxide (GO), a new type of nanomaterial in the carbon family, was prepared by Hummers method and used as adsorbent for DOX from aqueous solution. Read More

    Efficacy of fractional lasers in treating alopecia: a literature review.
    Lasers Med Sci 2017 Aug 16. Epub 2017 Aug 16.
    Department of Dermatology and Cutaneous Surgery, University of Miami Hospital, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.
    Hair loss stemming from different types of alopecia, such as androgenic alopecia and alopecia areata, negatively affects over half the population and, in many circumstances, causes serious psychosocial distress. Current treatment options for alopecia, such as minoxidil, anthralin, and intralesional corticosteroids, vary efficacy and side effect profiles. It is known that low-level laser/light therapies (LLLT), or photobiomodulations, such as the US FDA-cleared HairMax Lasercomb®, He-Ne laser, and excimer laser, are relatively affordable, user-friendly, safe, and effective forms of treatment for hair loss. Read More

    Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice.
    Exp Ther Med 2017 Aug 12;14(2):1001-1008. Epub 2017 Jun 12.
    Shanghai Municipality Key Laboratory of Veterinary Biotechnology, Department of Animal Sciences, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, P.R. China.
    Although hair loss or alopecia is a common disease, its exact mechanisms are not yet well understood. The present study investigated the hypothesis that the homeostatic regulation of genes during hair regeneration may participate in hair loss, based on the cyclicity of hair growth. A cluster of such genes was identified by an expression gene-array from the dorsal skin in a depilated mouse model, and CXCL4 was identified as a significantly regulated gene during the hair regeneration process. Read More

    Exposure to vector-borne pathogens in privately owned dogs living in different socioeconomic settings in Brazil.
    Vet Parasitol 2017 Aug 22;243:18-23. Epub 2017 May 22.
    Department of Immunology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil; Department of Veterinary Medicine, University of Bari, Valenzano, Italy. Electronic address:
    This survey was conducted in four Brazilian cities, from three federative units (Pernambuco, Minas Gerais, and Federal District), representing different socioeconomic settings, to determine the presence of antibodies to or antigens and DNA of selected pathogens in privately owned dogs. From January to April 2015, blood and serum samples were collected and assayed using different tests. In particular, antibodies to Anaplasma spp. Read More

    Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling.
    Mol Ther 2017 Jul 20. Epub 2017 Jul 20.
    Department of Surgery, Davis Heart and Lung Research Institute, Center for Regenerative Medicine & Cell-Based Therapies, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address:
    Unlike the epidermis, which regenerates continually, hair follicles anchored in the subcutis periodically regenerate by spontaneous repetitive cycles of growth (anagen), degeneration (catagen), and rest (telogen). The loss of hair follicles in response to injuries or pathologies such as alopecia endangers certain inherent functions of the skin. Thus, it is of interest to understand mechanisms underlying follicular regeneration in adults. Read More

    Evaluation of the Relationship between Alopecia Areata and Viral Antigen Exposure.
    Am J Clin Dermatol 2017 Aug 11. Epub 2017 Aug 11.
    Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY, 14621, USA.
    Background: Alopecia areata (AA) is an autoimmune disease characterized by non-scarring alopecia with T-cell infiltration at the affected hair follicle.

    Objective: Our aim was to study the potential link between hepatitis B virus (HBV) antigen exposure and AA.

    Methods: Two pediatric patients with AA following hepatitis B vaccination were identified in a general dermatology clinic. Read More

    Glycolipid and Hormonal Profiles in Young Men with Early-Onset Androgenetic Alopecia: A meta-analysis.
    Sci Rep 2017 Aug 10;7(1):7801. Epub 2017 Aug 10.
    Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
    Hormonal and metabolic abnormalities have been reported in men with early-onset androgenetic alopecia (AGA). Although this has been ascribed to the existence of a male polycystic ovary syndrome (PCOS)-equivalent, data on this topic are inconsistent and this syndrome has not been already acknowledged. To evaluate if, already before the age of 35 years, any difference occurs in the glycolipid and hormonal profiles and in the body weight in men with AGA compared to age-matched controls, we performed a comprehensive meta-analysis of all the available observational case-control studies of literature, using MEDLINE, Google Schoolar and Scopus databases. Read More

    Vitamin D Level in Alopecia Areata.
    Indian J Dermatol 2017 Jul-Aug;62(4):407-410
    Department of Dermatology, STD and Leprosy, Government Medical College, University of Kashmir, Srinagar, Jammu and Kashmir, India.
    Background: Alopecia areata (AA) is an immune-mediated disease in which autoantigens play an important part in activating T-lymphocytes. Vitamin D has been associated with various autoimmune diseases, and Vitamin D receptors are strongly expressed in hair follicles and their expression in keratinocytes is necessary for the maintenance of the normal hair cycle.

    Aim: The aim of this study was to find the association between Vitamin D level and AA. Read More

    A Practical Approach to the Diagnosis and Management of Hair Loss in Children and Adolescents.
    Front Med (Lausanne) 2017 24;4:112. Epub 2017 Jul 24.
    Department of Dermatology, Massachusetts General Hospital, Boston, MA, United States.
    Hair loss or alopecia is a common and distressing clinical complaint in the primary care setting and can arise from heterogeneous etiologies. In the pediatric population, hair loss often presents with patterns that are different from that of their adult counterparts. Given the psychosocial complications that may arise from pediatric alopecia, prompt diagnosis and management is particularly important. Read More

    Anti-SmD1 antibodies are associated with renal disorder, seizures, and pulmonary arterial hypertension in Chinese patients with active SLE.
    Sci Rep 2017 Aug 8;7(1):7617. Epub 2017 Aug 8.
    Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, No. 1 Shuaifuyuan, Beijing, 100730, China.
    Detection of autoantibodies in systemic lupus erythematosus (SLE) plays an important role in timely diagnosis and earlier treatment of SLE. In this study, we used a SmD1 polypeptide-based ELISA to determine anti-SmD1 antibody in 269 SLE, including100 naïve (had not been treated with steroids or immunosuppressants at study inception) SLE patients and 169 non-naive SLE patients; 233 controls with other rheumatic diseases (RDC) (70 RA, 40 AS, 73SSc, and 50 SS), and 110 healthy controls (HC) group. The positive rate of anti-SmD1 among all SLE patients was 60. Read More

    Analysis of health-related quality of life in patients with brain tumors prior and subsequent to radiotherapy.
    Oncol Lett 2017 Aug 6;14(2):1841-1846. Epub 2017 Jun 6.
    Department of Radiation Oncology, Martin Luther University Halle-Wittenberg, D-06120 Halle (Saale), Germany.
    Health-related quality of life (HRQOL) was evaluated for a patient cohort with benign or malignant brain tumors prior and subsequent to radiotherapy. The following inclusion criteria were applied: Sufficient compliance, understanding of patient information and the existence of a brain tumor without previous radiotherapy. Patients were asked to complete the European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-BN20 questionnaires at the following times: Prior to (t0) and subsequent to (t1) radiotherapy, and at 3 (t2), 6 (t3) and 12 (t4) months following treatment. Read More

    A Case of Alopecia Areata in a Patient with Turner Syndrome.
    Open Access Maced J Med Sci 2017 Jul 23;5(4):493-496. Epub 2017 Jul 23.
    Universitario di Ruolo, Dipartimento di Scienze Dermatologiche, Università degli Studi di Firenze, Facoltà di Medicina e Chirurgia, Dermatology, Via Vittoria Colonna 11, Rome 00186, Italy.
    The Authors report a case of alopecia areata totalis in a woman with Turner syndrome. Read More

    Trichorhinophalangeal Syndrome.
    Open Access Maced J Med Sci 2017 Jul 22;5(4):486-489. Epub 2017 Jul 22.
    Universita degli Studi di Messina, Clinical and Experimental Medicine, Section of Dermatology, Messina 98122, Italy.
    Trichorhinophalangeal syndrome (TRPS) is the collective name of three rare congenital conditions characterised by craniofacial and skeletal abnormalities. The three known types of TRPS have different modalities of genetic transmission: namely, TRPS I and III are inherited as an autosomal dominant disease, while the cases of TRPS II are essentially sporadic. The diagnosis of the different types of TRPS is based on clinical and radiological findings, eventually integrated by genetic analysis, particularly useful in some cases with the non-classical clinical presentation. Read More

    Long-Term Management with Adipose Tissue-Derived Mesenchymal Stem Cells and Conventional Treatment in a Dog with Hepatocutaneous Syndrome.
    J Vet Intern Med 2017 Aug 7. Epub 2017 Aug 7.
    Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
    Hepatocutaneous syndrome (HS) is an uncommon skin disorder that occurs in conjunction with liver disease and is diagnosed based on decreased plasma concentrations of amino acids and the histopathology of skin lesions. The survival period generally is <6 months. A 10-year-old castrated male Maltese dog was presented for evaluation of lethargy, polyuria, polydipsia, and skin lesions including alopecia, erythema, and crusts. Read More

    [Amoxicillin-induced skin rash sparing a plaque of erythema migrans: Renbök phenomenon: Case report and literature review].
    Ann Dermatol Venereol 2017 Aug 2. Epub 2017 Aug 2.
    Service de dermatologie, centre hospitalier René-Dubos, 6, avenue de l'île-de-France, 95300 Pontoise, France.
    Introduction: Renbök phenomenon describes the inhibition of a lesion when a different one appears. We describe the first case of Renbök phenomenon occurring in a context of erythema migrans (EM) spared by an amoxicillin-induced skin rash and we also present a literature review.

    Case Report: A 60-year-old patient was treated with amoxicillin for EM on the right knee and subsequently developed generalized erythema as a result of an antibiotic-induced skin rash, with sparing of the area previously affected by EM. Read More

    Metabolic syndrome in Iranian adolescents with polycystic ovary syndrome.
    Int J Adolesc Med Health 2017 Aug 5. Epub 2017 Aug 5.
    .
    Background Metabolic syndrome (MS) in adolescents is a risk factor for type 2 diabetes and cardiovascular diseases. Objective The present study aimed to determine the prevalence of MS in 14-18-year-old girls. Methods This analytical case-control study was conducted on 3200 high school students with polycystic ovarian syndrome (PCOS). Read More

    Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation.
    Sci Rep 2017 Aug 4;7(1):7311. Epub 2017 Aug 4.
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore.
    Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously and regulates actin cytoskeleton remodeling. In order to characterize the role of N-WASP in epidermal homeostasis and cutaneous biology, we generated conditional N-WASP knockout mouse using CK14-cre (cytokeratin 14) to ablate expression of N-WASP in keratinocytes. N-WASP(K14KO) (N-WASP (fl/fl) ; CK14-Cre) mice were born following Mendelian genetics suggesting that N-WASP expression in keratinocytes is not essential during embryogenesis. Read More

    Increased Expression of PD-L1 and PD-L2 in Dermal Fibroblasts from Alopecia Areata Mice.
    J Cell Physiol 2017 Aug 4. Epub 2017 Aug 4.
    Department of Surgery, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.
    Alopecia areata (AA) is a common autoimmune disorder affecting millions of people worldwide, which manifests as a sudden, non-scarring hair loss. The expression of a pro-inflammatory cytokine, interferon-gamma (INF-γ), has been well established to be involved in the development of AA. As IFN-γ and other cytokines are also known to up-regulate programmed cell death ligand 1 and 2 (PD-L1 and PD-L2), which both negatively control immune responses, we asked whether or not a high number of infiltrated T cells, seen in AA lesions, can modulate the expression of PD-L1 and PD-L2 in skin cells. Read More

    Paclitaxel, oxaliplatin, 5-fluorouracil and leucovorin combination chemotherapy in patients with recurrent or metastatic gastric cancer.
    Tumori 2017 Jul 27. Epub 2017 Jul 27.
    Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian - P.R. China.
    Purpose: This study evaluated the efficacy and toxicity of combination chemotherapy with paclitaxel, oxaliplatin, 5-fluorouracil and leucovorin (POFL) in patients with recurrent or metastatic gastric cancer.

    Methods: One hundred and thirty-eight patients with histologically confirmed recurrent or metastatic gastric adenocarcinoma were treated with the POFL regimen: paclitaxel at a dose of 135 mg/m2 as a 3-hour intravenous infusion on day 1, oxaliplatin 85 mg/m2 and leucovorin 400 mg/m2 as an intravenous infusion over 2 hours on day 1, followed by 5-fluorouracil 2,400 mg/m2 as an infusion over a 46-hour period on 3 consecutive days, in a 2-week cycle.

    Results: Twelve patients could not be evaluated for response because of the absence of any measurable lesions or early discontinuation of therapy, so responses were assessed in 126 patients. Read More


    Original article: Platelet-rich plasma with microneedling in androgenetic alopecia along with dermoscopic pre- and post-treatment evaluation.
    J Cosmet Dermatol 2017 Aug 3. Epub 2017 Aug 3.
    Department of Skin & V.D, Patna Medical College and Hospital, Patna, Bihar, India.
    Background: Platelet-rich plasma has shown beneficial effects in the treatment of androgenic alopecia with its growth factor properties in accelerating the dermal papilla. Dermoscopy is a noninvasive method that allows the in vivo evaluation of microstructures not visible to the naked eye.

    Objective: To ascertain the role of platelet-rich plasma (PRP) with microneedling, and to compare the pre- and post-treatment dermoscopic features in androgenetic alopecia. Read More

    Preparation and in vivo evaluation of lecithin-based microparticles for topical delivery of minoxidil.
    Arch Pharm Res 2017 Aug 2. Epub 2017 Aug 2.
    College of Pharmacy, Chungbuk National University, 194-31, Osongsangmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk, 28160, Republic of Korea.
    Minoxidil is widely used for treatment of androgenic alopecia. Commercial products containing minoxidil are usually in solution form. Repeated applications of minoxidil solution can lead to adverse effects such as skin irritation and horniness. Read More

    Diagnosis of acrodermatitis enteropathica in resource limited settings.
    BMJ Case Rep 2017 Aug 2;2017. Epub 2017 Aug 2.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    Acrodermatitis enteropathica (AE) is a rare inherited zinc deficiency that usually manifests in infancy within days in cases of bottlefed infants and days to weeks after weaning in breastfed infants. It is characterised by diarrhoea, dermatitis, alopecia and systemic symptoms. We report a case of acquired nutritional AE in a 6-month-old female infant who had diarrhoeal episodes and the characteristic dermatitis lesions in the acral and anogenital regions. Read More

    Human urine-based therapeutics in Spain from the early 20th century to the present: a historical literature overview and a present-day case study.
    Acta Med Hist Adriat 2017 Jun;15(1):73-108
    Departamento de Terapéutica Médico-Quirúrgica, Facultad de Medicina, Universidad de Extremadura, Badajoz, Spain.
    Human urine is currently the subject of biomedical investigations as a potential therapeutic resource and it continues to be used in remedies in different cultures and societies, including the Spanish culture. In this study we gather etnomedical knowledge about urotherapy and determine their associated symbolisms in Spain. A literature overview and a case study were carried out to compile urine-based remedies and as a direct analysis of symbolic systems. Read More

    Hairless controls hair fate decision via Wnt/β-catenin signaling.
    Biochem Biophys Res Commun 2017 Jul 29. Epub 2017 Jul 29.
    Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China. Electronic address:
    The hairless (Hr) gene plays a central role in the hair cycle, considering that mutations in the gene result in hair loss with the exception of a few vibrissae after the first hair growth cycle in both mice and humans. This study examinedthe uncommon phenotype and using microarray analyses and functional studies, we found that β-catenin was mediated by Hr. Progenitor keratinocytes from the bulge region differentiate into both epidermis and sebaceous glands, and fail to adopt the hair keratinocytes fate in the mutant scalp, due to the decreased Wnt/β-catenin signaling in the absence of the hairless protein. Read More

    Risk of hair loss with different antidepressants: a comparative retrospective cohort study.
    Int Clin Psychopharmacol 2017 Jul 31. Epub 2017 Jul 31.
    Departments of aOphthalmology and Visual Sciences bPsychology cPsychiatry dPediatrics, Division of Translational Therapeutics, Faculty of Medicine eBritish Columbia Children's Hospital Research Institute, University of British Columbia fPharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
    The aim of this study was to quantify the risk of hair loss with different antidepressants. A retrospective cohort study design using a large health claims database in the USA from 2006 to 2014 was utilized. A cohort of new user and mutually exclusive users of fluoxetine, fluvoxamine, sertraline, citalopram, escitalopram, paroxetine, duloxetine, venlafaxine, desvenlafaxine, and bupropion were followed to the first diagnosis of alopecia. Read More

    A Case Report of Verruca Vulgaris on basis of Alopecia Areata Successfully Treated with Diphenylcyclopropenone.
    Int J Trichology 2017 Jan-Mar;9(1):35-37
    Department of Dermatology, Goztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
    Alopecia areata is an autoimmune skin disease which is usually characterized by patchy hair loss in effected regions. Diagnosis usually based on clinical findings and main treatment options include topical, intralesional, systemic corticosteroids, and topical immunotherapy. Verruca vulgaris is an infectious disease caused by human papillomavirus which is usually characterized by well-marginated hyperkeratotic papules or plaques. Read More

    Acute Alopecia: Evidence to Thallium Poisoning.
    Int J Trichology 2017 Jan-Mar;9(1):30-32
    Department of Internal Medicine, Chennai Medical College and Research Centre, Trichy, Tamil Nadu, India.
    Thallium is a toxic heavy metal often involved in criminal poisonings and occasionally in accidental poisoning. Here, we report a case of acute, nonintentional thallium poisoning due to thallium-contaminated alternative medicine for its rarity and to create awareness about the combination of rapid, diffuse alopecia with neurologic and gastrointestinal symptoms among practitioners, professionals, public, and policymakers. Read More

    Presence of Mast Cells and Mast Cell Degranulation in Scalp Biopsies of Telogen Effluvium.
    Int J Trichology 2017 Jan-Mar;9(1):25-29
    Department of Dermatology, Saint Louis University, St. Louis, MO, USA.
    Background: Telogen effluvium (TE) is a type of acquired, diffuse alopecia that occurs due to an abnormal shift of scalp hair follicles from anagen to telogen, leading to premature shedding of hair. Previous studies have suggested the existence of a neuroimmunologic "brain-hair follicle" axis, in which mast cells have been implicated as an important link between the nervous system and immunologic system.

    Objective: The current study sought to investigate the role of mast cell presence and mast cell degranulation in the pathogenesis of TE. Read More

    A Comparative Study of Microneedling with Platelet-rich Plasma Plus Topical Minoxidil (5%) and Topical Minoxidil (5%) Alone in Androgenetic Alopecia.
    Int J Trichology 2017 Jan-Mar;9(1):14-18
    Department of Dermatology, Smt. NHL Municipal Medical College, VS General Hospital, Ahmedabad, Gujarat, India.
    Context: There are very few studies evaluating efficacy of platelet-rich plasma (PRP) in hair restoration and its combination with microneedling. As far as ascertained, there is no study to evaluate efficacy of microneedling with PRP plus topical minoxidil (5%) versus topical minoxidil (5%) alone in androgenetic alopecia (AGA).

    Aims: This study aims (1) to compare the efficacy of (a) topical minoxidil (5%) alone and (b) topical minoxidil (5%) + microneedling with PRP in men between 18 and 50 years with AGA Grade III to V vertex (Norwood-Hamilton scale) and (2) to perform objective and subjective evaluation based on clinical improvement and photographic evidence. Read More

    Clinical Issues-August 2017.
    AORN J 2017 Aug;106(2):162-171
    Caring for patients with tattoos undergoing magnetic resonance imaging (MRI) procedures Key words: magnetic resonance imaging, tattoos. Reducing slips, trips, and falls caused by electrical cords on the procedure room floor Key words: slips, trips, falls, electrical cords, equipment booms. Classifying surgical limb amputation wounds Key words: wound classification, documentation, amputation. Read More

    Brazilian Experience of the Treatment of Alopecia Universalis with the Novel Antirheumatic Therapy Tofacitinib: A Case Series.
    Rheumatol Ther 2017 Jul 28. Epub 2017 Jul 28.
    DermatoSineida Clinic Maringa, Paraná, Brazil.
    Introduction: Alopecia universalis is an autoimmune disorder for which there is no known effective therapy. Tofacitinib-a novel antirheumatic therapy for rheumatoid arthritis-has been shown in some reports to induce sustained hair growth in patients with alopecia universalis.

    Case Series: Here, we review the experiences of four different rheumatologists across the country regarding four Brazilian patients with alopecia universalis who were treated with tofacitinib . Read More

    Cabazitaxel Versus Docetaxel As First-Line Therapy for Patients With Metastatic Castration-Resistant Prostate Cancer: A Randomized Phase III Trial-FIRSTANA.
    J Clin Oncol 2017 Jul 28:JCO2016721068. Epub 2017 Jul 28.
    Stéphane Oudard, Georges Pompidou European Hospital, Rene Descartes University; Mustapha Chadjaa; Sanofi, Paris; Karim Fizazi, Institut Gustave Roussy, University of Paris Sud, Villejuif; Antoine Thiery-Vuillemin, Centre Hospitalier Universitaire Minjoz Besançon, Besançon, France; Lisa Sengeløv, Herlev Hospital, Herlev; Gedske Daugaard, Copenhagen University Hospital, Rigshospitalet, Copenhagen; Steinbjørn Hansen, Odense University Hospital, Odense, Denmark; Fred Saad, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada; Marie Hjälm-Eriksson, Karolinska University Hospital, Stockholm, Sweden; Jacek Jassem, Medical University of Gdansk, Gdansk, Poland; Orazio Caffo, Santa Chiara Hospital, Trento, Italy; Daniel Castellano, University Hospital 12 de Octubre, Madrid, Spain; Paul N. Mainwaring, Icon Cancer Care, Brisbane, Queensland, Australia; John Bernard, Sanofi, Cambridge, MA; Liji Shen, Sanofi, Bridgewater, NJ; and Oliver Sartor, Tulane Cancer Center, New Orleans, LA.
    Purpose In patients with metastatic castration-resistant prostate cancer (mCRPC), overall survival (OS) is significantly improved with cabazitaxel versus mitoxantrone after prior docetaxel treatment. FIRSTANA ( ClinicalTrials.gov identifier: NCT01308567) assessed whether cabazitaxel 20 mg/m(2) (C20) or 25 mg/m(2) (C25) is superior to docetaxel 75 mg/m(2) (D75) in terms of OS in patients with chemotherapy-naïve mCRPC. Read More

    Lichen planopilaris in a Latin American (Chilean) population: demographics, clinical profile and treatment experience.
    Clin Exp Dermatol 2017 Jul 27. Epub 2017 Jul 27.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, USA.
    Background: Lichen planopilaris (LPP) is characterized by lymphocytic infiltrate, fibrosis and potential destruction of the hair follicle. Demographic and clinical studies in LPP are limited, and racial differences have not been thoroughly investigated.

    Aim: To analyse epidemiological data and clinical profiles of Chilean adults with LPP, and report on the treatments used. Read More

    Validation of an Egyptian Arabic Version of Skindex-16 and Quality of Life Measurement in Egyptian Patients with Skin Disease.
    Int J Behav Med 2017 Jul 26. Epub 2017 Jul 26.
    Department of Dermatology and Venereology, Assiut University Hospital, Assiut, 71526, Egypt.
    Purpose: To translate and cross-culturally adapt the Skindex-16, a brief skin-disease-specific QoL questionnaire, into Arabic for Egyptians and to evaluate its measurement properties in Egyptian patients with skin disease.

    Method: Translation and cultural adaption were performed following guidelines for cross-cultural adaption of health-related quality of life measures. Subsequently, Skindex-16 was administered to 500 consecutive dermatological patients and 500 healthy persons for verification of its reliability and validity. Read More

    Comorbid autoimmune diseases in patients with pemphigus: a nationwide case-control study in Taiwan.
    Eur J Dermatol 2017 Jul 27. Epub 2017 Jul 27.
    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Dermatology, National Yang-Ming University, Taipei, Taiwan.
    Previous studies have proposed the association between pemphigus and several autoimmune diseases, but no large-scale study has been reported. To delineate the association between pemphigus and autoimmune diseases including psoriasis. A total of 1,998 patients with pemphigus and 7,992 control subjects were enrolled from the National Health Insurance Research Database in Taiwan from 1997 to 2010. Read More

    Change in PSA concentration in men with PSA < 2.5 ng/mL taking low-dose finasteride or dutasteride for male androgenetic alopecia.
    J Urol 2017 Jul 22. Epub 2017 Jul 22.
    Department of Urology, School of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, South Korea; Chungbuk National University Hospital, Cheongju, South Korea.
    Purpose: This retrospective cohort study aimed to assess the effect on PSA concentrations of low-dose finasteride or dutasteride treatment for male androgenetic alopecia whose baseline serum PSA < 2.5 ng/mL.

    Patients And Methods: The cohort consisted of 1,379 consecutive male patients who were treated for androgenetic alopecia with finateride 1. Read More

    FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling.
    Adv Radiat Oncol 2016 Jul-Sep;1(3):170-181. Epub 2016 Jun 4.
    Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Chiba, Japan.
    Purpose: Telogen (resting phase) hair follicles (HFs) are more radioresistant than their anagen (growth phase) counterparts. Fibroblast growth factor (FGF) 18 is strongly expressed in telogen HFs to maintain the telogen phase, whereas several other FGFs exert radioprotective effects; however, the role of FGF18 in the radioresistance of HFs remains unknown. This study focused on clarifying the role of FGF18 in the radioresistance of telogen HFs and its potential as a radioprotector. Read More

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