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    1 OF 398

    An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch Type Alopecia Areata, Totalis and Universalis.
    J Invest Dermatol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Dermatology. Electronic address:
    Alopecia areata (AA) is a common autoimmune disease, with a lifetime risk of ∼2%. In AA, the immune systems targets the hair follicle, resulting in clinical hair loss. AA prognosis is unpredictable, and currently there is no definitive treatment. Read More

    Fractional non-ablative laser-assisted drug delivery leads to improvement in male and female pattern hair loss.
    J Cosmet Laser Ther 2018 Feb 16:1-4. Epub 2018 Feb 16.
    a Clínica Groenlândia 462 , São Paulo-Brasil , Brazil.
    Androgenetic alopecia, also known as male and female pattern hair loss, is a very prevalent condition; however, approved therapeutic options are limited. Fractionated laser has been proposed to assist in penetration of topical medications to the cutaneous tissue. We present four cases of androgenetic alopecia that underwent treatment with a non-ablative erbium glass fractional laser followed by the application of topical finasteride 0,05% and growth factors including basic fibroblast growth factor, insulin-like growth factor, vascular endothelial growth factor, and copper peptide 1%. Read More

    Use of an Alternating Inflatable Head Pad inPatients Undergoing Open Heart Surgery.
    Med Sci Monit 2018 Feb 16;24:970-976. Epub 2018 Feb 16.
    Department of Nursing, Yantai Yuhuangding Hospital, Yantai, Shandong, China (mainland).
    BACKGROUND Preoperative symptoms like occipital pressure ulcers and alopecia areata (AA) significantly lowered patient quality of life. Therefore, preoperative nursing was in need of investigation. This study aimed to compare effects of an alternating inflatable head pad and a gel pad on occurrence of postoperative pressure ulcers and AA in patients undergoing open heart surgery. Read More

    Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases.
    Exp Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodore Fontane, Dessau, Germany.
    Sebocytes, the major cell type in sebaceous glands (SGs), are differentiated epithelial cells that gradually accumulate lipids and eventually disrupt, releasing their content (sebum) in a secretory process known as holocrine secretion. Via the hair canal, sebum reaches the skin surface, where it has several known or postulated functions, including pheromonal, thermoregulatory, antimicrobial and antioxidant activities. Altered sebum secretion and/or structural SG changes have also been involved in the pathogenesis of skin diseases, such as acne vulgaris and some forms of alopecia. Read More

    Comparing the efficacy of low-dose vs high-dose cyclophosphamide regimen as induction therapy in the treatment of proliferative lupus nephritis: a single center study.
    Rheumatol Int 2018 Feb 15. Epub 2018 Feb 15.
    Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India.
    Cyclophosphamide (CYC) has been the backbone immunosuppressive drug to achieve sustained remission in lupus nephritis (LN). The aim was to evaluate the efficacy and compare adverse effects of low and high dose intravenous CYC therapy in Indian patients with proliferative lupus nephritis. An open-label, parallel group, randomized controlled trial involving 75 patients with class III/IV LN was conducted after obtaining informed consent. Read More

    Sexual side effects of 5-α-reductase inhibitors finasteride and dutasteride: A comprehensive review.
    Dermatol Online J 2017 Nov 11;23(11). Epub 2017 Nov 11.
    University of Miami, Miller School of Medicine, Department of Dermatology and Cutaneous Surgery, Miami, Florida.
    The 5-α-reductase inhibitors finasteride and dutasteride are frequently used in the treatment of androgenetic alopecia and benign prostatichyperplasia. These drugs are effective at reducing levels of dihydrotestosterone, the primary androgen responsible for the pathogenesis of both these conditions. However, finasteride and dutasteride have also been shown to produce an increase in the incidence of sexual dysfunction, namely, impotence, decreased libido, and ejaculation disorder. Read More

    Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia.
    J Vis Exp 2018 Jan 27(131). Epub 2018 Jan 27.
    Chief of Plastic and Reconstructive Surgery Department, University of Rome Tor Vergata.
    23 patients (18 male and 5 female) aged 21-70 years who displayed male pattern hair loss (MPHL) in Stage 1 to Stage 5 as determined by the Norwood-Hamilton classification scale, and female pattern hair loss (FPHL) in Stage 1 to Stage 2 as determined by the Ludwig classification scale, were treated with non-activated autologous platelet-rich plasma (A-PRP). Autologous blood (55 mL) was harvested using sodium citrate as an anticoagulant. A-PRP (23 mL) was produced for all cases using a closed system according to the transfusion service protocol. Read More

    Topical Immunotherapy of Alopecia Areata: A Large Retrospective Study.
    Dermatol Ther (Heidelb) 2018 Feb 13. Epub 2018 Feb 13.
    Dermatology Department of Centro Medico Polispecialistico, Pavia, Italy.
    Introduction: Topical immunotherapy is frequently used in the treatment of alopecia areata (AA) although few studies report long-term follow-up. Our goals were to determine the efficacy and the prognostic factors of topical immunotherapy in a large cohort of patients with AA treated in the departments of Dermatology and Venereology of Bergamo, Como and Pavia, from 1978 to January 2016.

    Methods: A total of 252 patients with AA were evaluated retrospectively. Read More

    Three Cases of Radiation-induced Temporary Alopecia with Hair Microscopic Examination: "Coudability Hair" Might Not be Specific for Alopecia Areata.
    Int J Trichology 2018 Jan-Feb;10(1):40-43
    Department of Dermatology, Busan Paik Hospital, Busan, Korea.
    Endovascular interventional procedures are widely used for the treatment of intracranial vascular lesions. However, they sometimes produce reversible alopecia, known as radiation-induced temporary alopecia, depending on the radiation dose. Radiation-induced temporary alopecia manifested as rectangular alopecic patches without signs of inflammation, reflects damage to the keratinocytes in the hair matrix of anagen hair follicles, due to the sensitivity of these cells to radiation. Read More

    Annular Alopecia Areata: A Morphologically Rare Variant.
    Int J Trichology 2018 Jan-Feb;10(1):34-36
    Department of Dermatology and Venereology, Government Medical College and Hospital, Chandigarh, India.
    Alopecia areata (AA) is the most common form of nonscarring alopecia involving the scalp and/or body. The most common pattern of hair loss is oval or round, but newer morphological variants are increasingly being described. We hereby report two cases of annular pattern of AA due to its unusual morphology. Read More

    Development of Frontal Fibrosing Alopecia with a History of Alopecia Areata.
    Int J Trichology 2018 Jan-Feb;10(1):29-30
    Department of Dermatology, University of California, Irvine, Irvine, California.
    Frontal fibrosing alopecia (FFA), a scarring type of alopecia, developed in two patients with a history of alopecia areata (AA). Both patients had biopsies to confirm this interesting series of pathology. Etiology and pathogenesis of this AA-to-FFA sequence will be discussed. Read More

    Whorled Scarring Alopecia - The Only Adult Marker of Incontinentia Pigmenti.
    Int J Trichology 2018 Jan-Feb;10(1):24-25
    Departments of Dermatology, Wrexham Maelor Hospital, Wrexham, Wales, UK.
    Incontinentia pigmenti (IP) is a rare X-linked dominant disease that affects the ectodermal tissues. It is associated with a whorled pattern of scarring alopecia, which is possibly underreported. This scarring alopecia could be used as a marker to identify adult women affected with IP as older patients may have minimal cutaneous manifestations. Read More

    Evaluation of Alopecia: A New Processing Technique Combining Vertical and Transverse Sections from a Single Scalp Biopsy Specimen.
    Int J Trichology 2018 Jan-Feb;10(1):11-16
    Department of Pathology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
    Background: Histopathological study of alopecia generally requires both vertical and transverse sections (VS and TS) and this may demand the need for multiple scalp biopsy samples. Here, we suggest a new processing technique which provides both VS and TS from a single biopsy, thus making the interpretation easier.

    Materials And Methods: All formalin-fixed scalp biopsy specimens were processed routinely. Read More

    A Meta-analysis On Evidence Of Platelet-rich Plasma for Androgenetic Alopecia.
    Int J Trichology 2018 Jan-Feb;10(1):1-10
    Department of Orthopaedics and Traumatology, Turku University Hospital, University of Turku, Turku, Finland.
    Background: Platelet-rich plasma (PRP) treatment has gained popularity among different surgical specialities for improving various conditions. Androgenetic alopecia (AGA) is a common disorder, with possible psychosocial implications. Plastic surgeons have increased the practice of PRP injections for hair restoration. Read More

    Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells.
    Int J Mol Sci 2018 Feb 12;19(2). Epub 2018 Feb 12.
    Department of Dermatology, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul 02259, Korea.
    Prostaglandin D2 (PGD2) and prostaglandin D2 receptor 2 (DP2) is known to be an important factor in androgenetic alopecia (AGA). However, the effect of PGD2 in human dermal papilla cells (hDPCs) is not fully understood. The function of PGD2-induced expression of the androgen receptor (AR), DP2, and AKT (protein kinase B) signal were examined by using real time-PCR (qRT-PCR), western blot analysis, immunocytochemistry (ICC), and siRNA transfection system. Read More

    Zinc and Skin Disorders.
    Nutrients 2018 Feb 11;10(2). Epub 2018 Feb 11.
    Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
    The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Read More

    A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424.
    Br J Cancer 2018 Feb 13. Epub 2018 Feb 13.
    University of Oxford Department of Oncology, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK.
    Background: Src is involved in cancer invasion and metastasis. AZD0424, an oral inhibitor of Src and ABL1, has shown evidence of anti-tumour activity in pre-clinical studies.

    Methods: A phase Ia, dose escalation study was performed to assess the safety of continuous oral dosing with AZD0424 in advanced solid tumours. Read More

    Olmsted Syndrome Caused by a Heterozygous p.Gly568Val Missense Mutation in TRPV3 Gene.
    Yonsei Med J 2018 Mar;59(2):341-344
    Department of Dermatology, Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Olmsted syndrome (OS) is a rare congenital skin disorder characterized by severe palmoplantar and periorificial keratoderma, alopecia, onychodystrophy, and severe pruritus. Recently, pathogenic 'gain-of-function' mutations of the transient receptor potential vanilloid 3 gene (TRPV3), which encodes a cation channel involved in keratinocyte differentiation and proliferation, hair growth, inflammation, pain and pruritus, have been identified to cause OS. Due to the rarity, the pattern of inheritance of OS is still unclear. Read More

    A biallelic ANTXR1 variant expands the anthrax toxin receptor associated phenotype to tooth agenesis.
    Am J Med Genet A 2018 Feb 13. Epub 2018 Feb 13.
    Center for Craniofacial Research, University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas.
    Tooth development is regulated by multiple genetic pathways, which ultimately drive the complex interactions between the oral epithelium and mesenchyme. Disruptions at any time point during this process may lead to failure of tooth development, also known as tooth agenesis (TA). TA is a common craniofacial abnormality in humans and represents the failure to develop one or more permanent teeth. Read More

    Characteristics of systemic lupus erythematosus in a sample of the Egyptian population: a retrospective cohort of 1109 patients from a single center.
    Lupus 2018 Jan 1:961203317751856. Epub 2018 Jan 1.
    6 Rheumatology and Rehabilitation Department, Military Academy, Agouza Rheumatology and Rehabilitation Centre, Giza, Egypt.
    Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can vary among different ethnic and racial groups. Objective The objective of this paper is to study the prevalence of various manifestations of SLE in a sample of the Egyptian population. Patients and methods Information in this study was derived from the medical records of SLE patients who sought medical advice at a private clinic in Cairo from January 1980 to June 2016. Read More

    Sesquiterpene-Enriched Extract of Curcuma aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study.
    Skin Pharmacol Physiol 2018 Feb 9;31(2):99-106. Epub 2018 Feb 9.
    Bioscreening Unit, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.
    Background: Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. Read More

    Efficacy and Safety of Rituximab in Children With Steroid- and Cyclosporine-resistant and Steroid- and Cyclosporine-dependent Nephrotic Syndrome.
    Iran J Kidney Dis 2018 Jan;12(1):27-32
    Division of Pediatric Nephrology, Pediatric Renal Transplantation and Dialysis Research Center, Iran University of Medical Sciences, Tehran, Iran.
    Introduction: There is evidence of the effectiveness of rituximab in treatment of nephrotic syndrome in children. The present study aimed to assess safety and the therapeutic effectiveness of rituximab in steroid- and cyclosporine-resistant pediatric nephrotic syndrome.

    Materials And Methods: Forty-three children with steroid- and cyclosporine-resistant or steroid- and cyclosporine-dependent noncongenital nephrotic syndrome were included in the study to receive intravenous rituximab, 375 mg/m2/wk, for 4 weeks. Read More

    Ginseng phytochemicals as therapeutics in oncology: Recent perspectives.
    Biomed Pharmacother 2018 Feb 5;100:52-63. Epub 2018 Feb 5.
    School of Food and Agricultural Sciences, University of Management and Technology, Lahore 54000, Pakistan; Center of Chemistry and Biotechnology, Deakin University, Waurn Ponds, Victoria, 3217, Australia. Electronic address:
    During the last few decades, cancer has mushroomed as a major health issue; and almost all drugs used for its therapy are very toxic with lethal side effects. Complementary and alternative medicines gain popularity among health professionals in recent era owing to its preventive mechanism against side effect chemotherapeutic drugs. Efforts are focused by scientists to isolate compounds from medicinal plant that have chemotherapeutic attributes; and ability to neutralize the side effects of chemotherapy. Read More

    Vinflunine for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract: an evidence-based review of safety, efficacy, and place in therapy.
    Core Evid 2018 24;13:1-12. Epub 2018 Jan 24.
    Division of Urology.
    Background: A systematic review and meta-analysis of the use of systemic vinflunine (VIN) in the treatment of urothelial carcinoma (UC) was performed to evaluate its efficacy based on current available clinical data.

    Methods: This review was prospectively registered at the International Prospective Register of Systematic Reviews, PROSPERO (registration CRD42016049294). Electronic databases including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were searched through December 2016. Read More

    EXPRESSION III: Patient´s Expectations and Preferences regarding Physician-Patient Relationship and Clinical Management. Results of the International NOGGO/ENGOT-ov4-GCIG study in 1,830 Ovarian Cancer Patients from European countries.
    Ann Oncol 2018 Feb 5. Epub 2018 Feb 5.
    Charité - Universitätsmedizin Berlin, corporate member of FreieUniversitätBerlin, Humboldt-Universität zu Berlin, and Berlin, Institute of Health,Department of Gynecology, EuropeanCompetence Center for OvarianCancer.
    Backround: The primary aim of this study was to investigate information needs and treatment preferences of patients with ovarian cancer, focusing especially on physician-patient relationship and treatment.

    Patients And Methods: A questionnaire was developed based on the experiences of the national German survey Expression II, and was provided to patients with ovarian cancer either at initial diagnosis or with recurrent disease via Internet (online-version) or as print-out-version.

    Results: From December 2009 to October 2012, a total of 1,830 patients with ovarian cancer from eight European countries (Austria, Belgium, France, Germany, Italy, Poland, Romania, Spain) participated, 902 (49. Read More

    Unusual progression of renal cell carcinoma with carcinomatosis peritoneii and Krukenberg tumour and alopecia with sunitinib therapy in young female.
    World J Surg Oncol 2018 Feb 6;16(1):23. Epub 2018 Feb 6.
    Lab Head, SRL Religere, Varanasi, 221005, India.
    Background: Sunitinib is a multiple receptor tyrosine kinase inhibitor (TKI) used for the treatment of renal cell carcinoma (RCC). It increases the median survival considerably with minimum side effects. Alopecia is one of the rare side effects. Read More

    Measuring Disease Damage and its Severity in Childhood-Onset Systemic Lupus Erythematosus.
    Arthritis Care Res (Hoboken) 2018 Feb 6. Epub 2018 Feb 6.
    Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, Ohio, USA.
    Objectives: To describe the frequency and types of disease damage occurring with childhood-onset systemic lupus erythematosus (cSLE) as measured by the 41-item Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), and to assess the SDI's ability to reflect damage severity.

    Methods: Information for the SDI was prospectively collected from 1,048 cSLE patients. For a subset of 559 patients physician-rated damage severity measured by visual analog scale (MD-VAS) was also available. Read More

    A hypothetical pathogenesis model for androgenic alopecia: clarifying the dihydrotestosterone paradox and rate-limiting recovery factors.
    Med Hypotheses 2018 Feb 30;111:73-81. Epub 2017 Dec 30.
    Economics, University of California, Berkeley, United States. Electronic address:
    Androgenic alopecia, also known as pattern hair loss, is a chronic progressive condition that affects 80% of men and 50% of women throughout a lifetime. But despite its prevalence and extensive study, a coherent pathology model describing androgenic alopecia's precursors, biological step-processes, and physiological responses does not yet exist. While consensus is that androgenic alopecia is genetic and androgen-mediated by dihydrotestosterone, questions remain regarding dihydrotestosterone's exact role in androgenic alopecia onset. Read More

    Characterisation of the French ferret population, husbandry, reported medical care and feeding habits.
    J Nutr Sci 2018 31;7:e4. Epub 2018 Jan 31.
    CHV St Martin Bellevue, St Martin Bellevue, France.
    Ferrets have become a common companion animal. But no data are available on the French population of ferrets. The goal of the survey was to characterise this population, including demographic characteristics, husbandry, reported medical care and feeding habits. Read More

    Utility of horizontal and vertical sections of scalp biopsies in various forms of primary alopecias.
    J Lab Physicians 2018 Jan-Mar;10(1):95-100
    Department of Pathology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
    Background: This study was performed to demonstrate the usefulness of horizontal and vertical sections of scalp biopsies in diagnosing various forms of primary alopecias and to highlight the importance of error-free grossing.

    Materials And Methods: A retrospective analytical review of 228 scalp biopsies was done, noting down the diagnostic histopathological features evident in horizontal and vertical sections of each cases. The idealness of the sections, especially horizontal section, was also analyzed. Read More

    A Pilot Study to Evaluate Effectiveness of Botulinum Toxin in Treatment of Androgenetic Alopecia in Males.
    J Cutan Aesthet Surg 2017 Jul-Sep;10(3):163-167
    Department of Dermatology, Base Hospital, Kolkata, West Bengal, India.
    Introduction: Androgenetic alopecia is a common form of alopecia with multifactorial etiology. Finasteride and minoxidil are approved by the FDA for the treatment of androgenetic alopecia. Balding scalp is believed to have relative microvascular insufficiency. Read More

    Standardization of SMP Procedure and Its Impact On Outcome.
    J Cutan Aesthet Surg 2017 Jul-Sep;10(3):145-149
    Department of Dermatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India.
    Background: Cosmetic deformities can result from various types of alopecia or even post hair transplantation procedures. Patients with such deformities seek aesthetically appealing longer-lasting options. Scalp concealers are commonly used by men and women to camouflage these deformities. Read More

    [Renaissance medicine and the discovery of the lesser circulation: the role of Michael Servetus (1511-1553)].
    Acta Med Hist Adriat 2017 Dec;15(2):271-282
    Dipartimento di Scienze della Salute, Sezione di Storia della Medicina ed Etica, Università di Genova, Genova, Italia.
    Human urine is currently the subject of biomedical investigations as a potential therapeutic resource and it continues to be used in remedies in different cultures and societies, including the Spanish culture. In this study we gather etnomedical knowledge about urotherapy and determine their associated symbolisms in Spain. A literature overview and a case study were carried out to compile urine-based remedies and as a direct analysis of symbolic systems. Read More

    Monilethrix: A case report imaged by trichoscopy, reflectance confocal microscopy and histopathology.
    Australas J Dermatol 2018 Feb 5. Epub 2018 Feb 5.
    Alopecia and Hair Disorders Section, Dermato-Oncology Clinic, Faculty of Medicine, Autonomous National University of Mexico, Mexico City, Mexico.

    Oligosecretory Myeloma With Amyloidosis and Alopecia.
    J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709617752737. Epub 2018 Jan 24.
    Albany Stratton VA Medical Center, Albany, NY, USA.
    Amyloidosis is a systemic illness characterized by the extracellular deposition of abnormal proteins in body tissues and organs. In addition to renal involvement, amyloidosis can also present with a variety of skin manifestations, though rarely with alopecia. Sixteen cases of alopecia secondary to systemic amyloidosis are reported. Read More

    Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria.
    Mol Ther 2017 Dec 19. Epub 2017 Dec 19.
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:
    Classical homocystinuria (HCU) is the most common inherited disorder of sulfur amino acid metabolism caused by deficiency in cystathionine beta-synthase (CBS) activity and characterized by severe elevation of homocysteine in blood and tissues. Treatment with dietary methionine restriction is not optimal, and poor compliance leads to serious complications. We developed an enzyme replacement therapy (ERT) and studied its efficacy in a severe form of HCU in mouse (the I278T model). Read More

    Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells.
    Arch Pharm Res 2018 Feb 3. Epub 2018 Feb 3.
    College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon, 406-799, Republic of Korea.
    Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Read More

    Dorsal thermal necrosis in dogs: a retrospective analysis of 16 cases in the southwestern USA (2009-2016).
    Vet Dermatol 2018 Feb 1. Epub 2018 Feb 1.
    DVM Pathology, 4122 East Agave Road, Phoenix, AZ, 85044, USA.
    Background: Prolonged sun exposure in high ambient temperatures has been recognized as a cause of thermal burns on the dorsal skin of dogs, termed dorsal thermal necrosis (DTN).

    Hypotheses/objectives: To characterize the clinical presentation, histopathology and outcomes of 16 dogs diagnosed with DTN and to identify associated risk factors.

    Animals: Sixteen dogs diagnosed with DTN. Read More

    Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non-inferiority study.
    Vet Dermatol 2018 Feb 1. Epub 2018 Feb 1.
    Veterinary Medicine Research and Development, Zoetis, 333 Portage St, Kalamazoo, MI, 49007, USA.
    Background: Various treatments are available for ear mite infestations in dogs.

    Objective: The efficacy of sarolaner was evaluated against ear mite infestation caused by Otodectes cynotis in dogs and compared with topical moxidectin/imidacloprid in a single-masked, multi-centre field study.

    Animals: Client-owned dogs with O. Read More

    Caprine herpesvirus 2-associated malignant catarrhal fever of captive sika deer (Cervus nippon) in an intensive management system.
    BMC Vet Res 2018 Feb 1;14(1):38. Epub 2018 Feb 1.
    Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, No. 4899 Juye St., Jingyue District, Changchun, 130112, China.
    Background: Caprine herpesvirus 2 (CpHV-2) infection usually induces chronic malignant catarrhal fever (MCF) in sika deer (Cervus nippon), with the primary signs of weight loss, dermatitis and alopecia.

    Case Presentation: Here, we report a case of CpHV-2-associated acute MCF in a sika deer herd raised in an intensive management system distant to the reservoir goats. Affected deer developed clinical signs of high fever (41 °C) followed by nasal discharge and lameness. Read More

    Short-course neoadjuvant chemoradiotherapy and surgery are beneficial in Chinese patients: A retrospective study.
    Medicine (Baltimore) 2017 Dec;96(51):e9394
    Nursing Department.
    Preoperative neoadjuvant chemoradiotherapy (NACR) is used to reduce tumor size for easier resection or improved resectability rates. Considering the difficulties regarding health insurance and health resources in China, an evidence-based short-course neoadjuvant chemoradiotherapy with surgery to cure patients was performed. This study compared the postoperative effects between short-course neoadjuvant chemoradiotherapy and surgery and surgery without neoadjuvant chemoradiotherapy. Read More

    Clinical and histopathological aspects of an alopecia syndrome in captive Andean bears (Tremarctos ornatus).
    Vet Dermatol 2018 Jan 31. Epub 2018 Jan 31.
    VetAgro Sup, UP Interactions Cellules Environnement, Univ Lyon, 1 Avenue Bourgelat, 69280, Marcy l'Etoile, France.
    Background: Captive Andean bears (Tremarctos ornatus) develop a distinct alopecic syndrome of unknown aetiology.

    Hypothesis/objectives: To describe the histological features of healthy Andean bear skin, to define the clinical and histopathological features of Andean bears with signs of alopecia, and to propose an aetiopathogenesis.

    Animals: Eighteen healthy Andean bears housed in 12 European zoos and 13 Andean bears with mild to severe alopecia housed in nine European zoos. Read More

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