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    The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm.
    Adv Ther 2017 Jun 23. Epub 2017 Jun 23.
    Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Alopecia areata (AA), a prevalent inflammatory cause of hair loss, lacks FDA-approved therapeutics for extensive cases, which are associated with very poor rates of spontaneous hair regrowth and major psychological distress. Current treatments for severe cases include broad immune-suppressants, which are associated with significant adverse effects, precluding long-term use, with rapid hair loss following treatment termination. As a result of the extent of the disease in severe cases, topical contact sensitizers and intralesional treatments are of limited use. Read More

    The Changing Landscape of Alopecia Areata: The Translational Landscape.
    Adv Ther 2017 Jun 23. Epub 2017 Jun 23.
    Columbia University Medical Centre, Russ Berrie Medical Pavilion, New York City, NY, USA.
    Recent genetic and preclinical studies have increased our understanding of the immunopathogenesis of alopecia areata (AA). This has allowed expedited development of targeted therapies for the treatment of AA, and a paradigm shift in our approach and understanding of autoimmunity and the hair follicle. The synergy between preclinical studies, animal models, and translational studies has led to unprecedented advances in the treatment options for AA, ultimately benefiting patients who have had little recourse. Read More

    The Changing Landscape of Alopecia Areata: An Introduction.
    Adv Ther 2017 Jun 23. Epub 2017 Jun 23.
    Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Alopecia areata is an extremely common autoimmune condition affecting hair. Severe forms of alopecia areata exist, with existing treatments consisting of systemic immunosuppressants with numerous side effects. Recently, breakthroughs have been made in both understanding the pathogenesis of alopecia areata and the treatment thereof, which hold the promise of being able to target severe cases of alopecia areata with more efficacy and better tolerability. Read More

    Extraintestinal Manifestations of Celiac Disease: Effectiveness of the Gluten-Free Diet.
    J Pediatr Gastroenterol Nutr 2017 Jul;65(1):75-79
    *Department of Pediatrics, University of Chicago Medicine Comer Children's Hospital, Chicago, IL †Department of Pediatrics, Università degli Studi di Verona, Verona, Italy.
    Objective: The aim of the study was to evaluate the effectiveness of the gluten-free diet (GFD) on extraintestinal symptoms in pediatric and adult celiac populations at the University of Chicago.

    Methods: We conducted a retrospective chart review of the University of Chicago Celiac Center clinic charts from January 2002 to October 2014. Demographics, serologic testing, intestinal biopsies, and extraintestinal symptoms at presentation, 12, 24, and >24 months were recorded. Read More

    [Clinical Efficacy and Safety of CMOD Regimen as the First Treatment for Aged New-diagnosed Patients with Peripheral T-cell Lymphoma].
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017 Jun;25(3):791-795
    Department of Hematology, Baoding Municipal First Central Hospital, Baoding 071000, Hebei Provience, China.
    Objective: To investigate clinical efficacy and safety of CMOD regimen as the first treatment for the aged new-diagnosed patients with peripheral T-cell lymphoma.

    Methods: Seventy-six patients diagnosed as peripheral T cell lymphoma according to chemotherapy were divided into the 2 group: A and B groups. The patients in A group received CMOD regimen (38 cases) and the patients in B group received CHOP regiment (38 cases). Read More

    Association between Helicobacter Pylori Infection and Alopecia Areata: A Study in Iranian Population.
    Middle East J Dig Dis 2017 Apr;9(2):107-110
    Dermatology Resident, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    BACKGROUND Alopecia areata is an immune mediated inflammatory hair loss, which occurs in all ethnic and age groups, and both sexes. However no significant etiology has been known for this disease. Helicobacter pylori (H. Read More

    FOXN1 Italian founder mutation in Indian family: Implications in prenatal diagnosis.
    Gene 2017 Jun 18. Epub 2017 Jun 18.
    Sandor Life Sciences Pvt Ltd., Banjara Hills, Road No: 3, Hyderabad 500034, India.
    The Forkhead box N1 (FOXN1) is a transcriptional factor regulating the development, differentiation and function of thymic epithelial cells; maintaining T-lineage progenitors in bone marrow; promoting terminal differentiation of epithelial cells of hair follicles. Mutation in FOXN1 was reported to cause a rare disorder characterized by rudimentary thymus gland, T-cell immunodeficiency, congenital alopecia and nail dystrophy within an Italian community. This is the first report of FOXN1 p. Read More

    Sorafenib in Japanese Patients With Locally Advanced or Metastatic Medullary Thyroid Carcinoma and Anaplastic Thyroid Carcinoma.
    Thyroid 2017 Jun 21. Epub 2017 Jun 21.
    Bayer Yakuhin, Ltd., 8Medical Affairs, Oncology and Hematology, and Clinical Development, Specialty Medicine, Tokyo, Japan ;
    Background: Therapeutic options for treating advanced or metastatic medullary thyroid carcinoma (MTC) and anaplastic thyroid carcinoma (ATC) are still limited in Japan even though vandetanib for MTC, and lenvatinib for MTC and ATC have been approved. Sorafenib is an oral multikinase inhibitor approved for the treatment of patients with radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC). We conducted an uncontrolled, open-label, multicenter, single-arm, phase 2 clinical study to evaluate the safety and efficacy of sorafenib in Japanese patients with MTC and ATC. Read More

    A Case of Topical Ruxolitinib Treatment Failure in Alopecia Areata.
    J Cutan Med Surg 2017 Jun 1:1203475417716363. Epub 2017 Jun 1.
    1 University of Toronto, Toronto, Ontario, Canada.
    Alopecia areata (AA) is an autoimmune-mediated, nonscarring form of hair loss. Despite its prevalence, current management options are limited, especially when the disease has progressed to alopecia totalis (AT) or alopecia universalis (AU). Recent evidence that janus kinase (JAK) signaling contributes to AA pathogenesis prompted the investigation of JAK inhibitors such as tofacitinib and ruxolitinib as possible oral treatments. Read More

    Management of alopecia areata: Updates and algorithmic approach.
    J Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Dermatology, Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Alopecia areata is a chronic, recurrent and non-scarring alopecia. The prognoses of patients are very diverse. The larger the area of hair loss, the poorer the treatment response and greater the probability of chronic disease progression. Read More

    Tumor necrosis factor-induced alopecia: alternative pathology and therapy.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Department of Dermatology, University of California San Diego, La Jolla, CA.
    Tumor necrosis factor (TNF) inhibitors are used to treat Crohn disease and psoriasis. Although they are typically well tolerated, adverse effects include the development of alopecia, and paradoxically, psoriatic lesions. We recently described a woman with Crohn disease who developed alopecia and scalp psoriasis during infliximab therapy. Read More

    Excellent response to tofacitinib in a patient with alopecia universalis.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Jun;26(2):47-49
    Department of Dermatology, Gazi University Hospital, Ankara, Turkey.
    EAlopecia universalis (AU) is generally considered a variant of alopecia areata (AA), in which the treatment options seldom provide satisfactory results. However, successful treatment of several cases of AA and its variants with oral Janus kinase (JAK) inhibitors have been reported recently. Here we report a 23-year-old female patient with AU successfully treated with tofacitinib, a selective JAK-3 inhibitor. Read More

    A CARASIL Patient from Americas with Novel Mutation and Atypical Features: Case Presentation and Literature Review.
    Cerebrovasc Dis 2017 06 21;44(3-4):135-140. Epub 2017 Jun 21.
    Department of Neurosurgery, New Jersey Medical School, Rutgers University, Newark, NJ, USA
    Objective: Reporting a novel mutation in the HTRA1 gene in a CARASIL patient from Americas.

    Methods: Clinical presentation and neuroimaging were consistent with CARASIL. HTRA1 DNA sequencing was performed using advanced ("next generation") sequencing technology. Read More

    The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    J Drugs Dermatol 2017 May;16(5):496-500

    Biotin, also known as Vitamin B7 or vitamin H, is a water-soluble B vitamin that acts as an essential cofactor for several carboxylases involved in the cellular metabolism of fatty acids, amino acids, and gluconeogenesis. Although there exists an incredible amount of social media hype and market advertising touting its efficacy for the improvement of hair quantity and quality, biotin's efficacy for hair remains largely unsubstantiated in scientific literature. We reviewed all pertinent scientific literature regarding the efficacy of biotin supplementation for hair growth and quality improvement, and we also investigated its popularity in society defined as a function of market analytics. Read More

    Methotrexate for the Treatment of Pediatric Alopecia Areata.
    J Dermatolog Treat 2017 Jun 19:1-12. Epub 2017 Jun 19.
    a Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC.
    Alopecia areata is a form of nonscarring hair loss which occurs in pediatric and adult patients, with presentation varying from round or ovoid patches of alopecia to alopecia totalis or universalis. While frustrating for patients, it can also be frustrating for clinicians to treat, as there is no definitive treatment. Dermatologists are very familiar with the use of methotrexate for psoriasis and other inflammatory skin diseases, and this medication is generally well tolerated in children. Read More

    From basal cell morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots.
    Br J Dermatol 2017 Jun 18. Epub 2017 Jun 18.
    Oncology Unit, 1st Department of Dermatology, University of Athens, Andreas Syggros Hospital, Athens, Greece.
    The deciphering of the hedgehog (Hh) signaling pathway implicated in the tumorigenesis of basal cell carcinoma (BCC), led to the development of targeted drug therapies, e.g. the hedgehog pathway inhibitors (HPI), vismodegib and sonidegib. Read More

    Histologic features of chronic cutaneous lupus erythematosus of the scalp using horizontal sectioning: Emphasis on follicular findings.
    J Am Acad Dermatol 2017 Jun 14. Epub 2017 Jun 14.
    Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Background: Chronic cutaneous lupus erythematosus (CCLE) often affects the scalp resulting in scarring alopecia. While histopathologic findings of CCLE have been well described, there is little written on the morphologic changes to the hair follicles in this condition.

    Objective: We aim to determine the histopathologic findings of hair follicles in CCLE of the scalp. Read More

    Laryngeal Neuropathy in Adult Goats With Copper Deficiency.
    Vet Pathol 2017 Jul 14;54(4):676-682. Epub 2016 Dec 14.
    5 Laboratorio de Diagnostico Animal, DMFA/UFRPE, Recife, Pernambuco, Brazil.
    The aim of this study was to elucidate the cause of a neurological syndrome characterized by stridor in adult goats with clinical signs of copper deficiency. The main clinical signs consisted of apathy, emaciation, pale mucous membranes, mucous nasal discharge, dyspnea, severe achromotrichia, diffuse alopecia, torpor, ataxia, and stridor. When the goats were forced to move, the stridor increased. Read More

    Skin findings in autoimmune and nonautoimmune thyroid disease with respect to thyroid functional status and healthy controls.
    Turk J Med Sci 2017 Jun 12;47(3):764-770. Epub 2017 Jun 12.
    Department of Dermatology, İstanbul Medeniyet University, Göztepe Research and Training Hospital, İstanbul, Turkey.
    Background/aim: Thyroid disorders are associated with a wide variety of skin disorders that respond to treatment of hormone imbalance in most cases and thus are of vital importance to dermatologists. This study aimed to evaluate skin findings associated with autoimmune and nonautoimmune thyroid disease with respect to thyroid functional status and healthy controls.

    Materials And Methods: A total of 300 consecutive patients with either autoimmune (n = 173) or nonautoimmune (n = 127) thyroid disease and 100 healthy control subjects were included in this cross-sectional study. Read More

    Comparing the Effects of Zinc Sulfate, Calcium Pantothenate, Their Combination and Minoxidil Solution Regimens on Controlling Hair Loss in Women: A Randomized Controlled Trial.
    J Res Pharm Pract 2017 Apr-Jun;6(2):89-93
    Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Science, Isfahan, Iran.
    Objective: This study was conducted to evaluate the combination of oral supplements with 2% minoxidil solution in four groups of women with hair loss.

    Methods: A prospective, randomized controlled trial was conducted from July to December 2016 in dermatology clinics affiliated to Isfahan University of Medical Sciences. A total of 73, 15-45-year-old, women with hair loss participated in this 4-month study. Read More

    Exacerbation of alopecia areata: A possible complication of sodium tetradecyl sulphate foam sclerotherapy treatment for varicose veins.
    SAGE Open Med Case Rep 2017 2;5:2050313X17712643. Epub 2017 Jun 2.
    Absolute Aesthetics, Guildford, UK.
    A 40-year-old woman with a history of alopecia areata related to stress or hormonal changes was treated for bilateral primary symptomatic varicose veins (CEAP clinical score C2S) of pelvic origin, using a staged procedure. Her first procedure entailed pelvic vein embolisation of three pelvic veins using 14 coils and including foam sclerotherapy of the tributaries, using 3% sodium tetradecyl sulphate. Following this procedure, she had an exacerbation of alopecia areata with some moderate shedding of hair. Read More

    The autoimmune burden in juvenile idiopathic arthritis.
    Ital J Pediatr 2017 Jun 14;43(1):56. Epub 2017 Jun 14.
    Pediatric Unit, Department of Medical and Surgical Sciences, S. Orsola - Malpighi Hospital, University of Bologna, Bologna, Italy.
    Background: Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis of unknown origin which can be considered an autoimmune disease (AD). The aim of this study is to analyse the presence of two or more autoimmune diseases (polyautoimmunity) in patients suffering from JIA and to evaluate the occurrence of ADs in their families.

    Methods: Seventy-nine patients diagnosed with JIA aged 0-21 years, admitted to the Paediatric Rheumatology Unit, Sant'Orsola-Malpighi Hospital, Bologna were screened for ADs. Read More

    Is the Second to Fourth Digit Ratio (2D:4D) a Biomarker of Sex-Steroids Activity?
    Pediatr Endocrinol Rev 2017 Jun;14(4):378-386
    Emeritus Director in Pediatrics, Children's Hospital "Santobono-Pausilipon", Naples, Italy.
    The second-to-fourth digit ratio (2D:4D) has been used as an indirect method to investigate the putative effects of prenatal exposure to androgens, and has been reported to be smaller in males than in females. This gender difference in digit length ratios has been linked with the in utero balance of androgens to oestrogen. This sexual dimorphism in 2D:4D ratios is apparent by 2 years of age and seems to be established early in life, possibly by the 14th week of gestation. Read More

    Anagen Effluvium in Association With Extracorporeal Membrane Oxygenation.
    Pediatr Dermatol 2017 Jun 13. Epub 2017 Jun 13.
    Division of Dermatology, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia.
    Anagen effluvium (AE) is a type of alopecia with hair loss during the growth phase of a hair follicle and is most often associated with cytotoxic chemotherapy. This report describes a case of AE in a critically ill 2-year-old boy who developed cardiorespiratory failure requiring extracorporeal membranous oxygenation. We postulate that the combination of hypotension and hypoxia with subsequent reperfusion triggered an apoptotic cascade in the hair matrix, resulting in AE. Read More

    Intermittent Chronic Telogen Effluvium.
    Skin Appendage Disord 2017 Mar 28;3(1):36-38. Epub 2017 Jan 28.
    University of Genoa, Genoa, Italy.
    Chronic telogen effluvium is most often intermittent, alternating periods of spontaneous remissions with episodes of unexplained relapses. This article reports the case of a male who was able to graphically depict the sequence of emotional events and the corresponding severity of his telogen effluvium during 31 months. The case is interesting as it documents for the first time the intermittency of chronic telogen effluvium and the pathogenetic role of emotional strains, and it stresses the importance of the modified wash test in evaluating the severity of hair shedding. Read More

    Common Allergens Identified Based on Patch Test Results in Patients with Suspected Contact Dermatitis of the Scalp.
    Skin Appendage Disord 2017 Mar 17;3(1):7-14. Epub 2016 Dec 17.
    Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
    Background: Contact dermatitis of the scalp is common and might be caused by many chemicals including metals, ingredients of shampoos and conditioners, dyes, or other hair treatments. Eliciting a careful history and patch tests are necessary to identify the responsible allergen and prevent relapses.

    Objectives: To identify allergens that may cause contact dermatitis of the scalp by reviewing patch test results. Read More

    Panniculitis Associated with MEK Inhibitor Therapy: An Uncommon Adverse Effect.
    Case Rep Dermatol 2017 Jan-Apr;9(1):80-85. Epub 2017 Mar 21.
    aDepartment of Dermatology, Université Paul Sabatier-Toulouse III et Institut Universitaire du Cancer de Toulouse, Toulouse, France.
    The combination of MEK inhibitor (cobimetinib, trametinib) and BRAF inhibitor (vemurafenib, dabrafenib) is now the first-line treatment in patients with BRAF V600-mutated metastatic melanoma. This association reduces cutaneous adverse events induced by BRAF inhibitors alone, including photosensitivity, hand-foot syndrome, hyperkeratosis, alopecia, skin papillomas, keratoacanthomas, and squamous-cell carcinomas. While panniculitis has exceptionally been reported with BRAF inhibitors, this rare side effect has never been described with the use of MEK inhibitors. Read More

    Psoriatic Alopecia in a Patient with Systemic Lupus Erythematosus.
    Case Rep Dermatol 2017 Jan-Apr;9(1):51-59. Epub 2017 Mar 3.
    Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Psoriasis is a chronic, recurrent, and relatively common inflammatory dermatologic condition, which demonstrates various clinical manifestations including hair loss. It was once believed that alopecia was not a presentation of scalp psoriasis, but it is now widely accepted that psoriatic alopecia exists. Although the majority of patients get hair regrowth, it can potentially lead to permanent hair loss. Read More

    Histopathologic Findings of Cutaneous Hyperpigmentation in Addison Disease and Immunostain of the Melanocytic Population.
    Am J Dermatopathol 2017 May 31. Epub 2017 May 31.
    *Department of Cellular Pathology, CellCOM-SB Group, Servicio de Anatomía Patologica, Hospital El Bierzo, Cellular Pathology, Ponferrada, Spain; †Department of CellCOM-SB Group, Biomedical Investigation Institute of A Coruña, CellCOM-SB Group, A Coruña, Spain; ‡Department of Cellular Pathology, Hospital de la Reina, Cellular Pathology, Ponferrada, Spain; and §Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, CA.
    The histopathological features of cutaneous hyperpigmentation in Addison disease have very occasionally been reported, and they include acanthosis, hyperkeratosis, focal parakeratosis, spongiosis, superficial perivascular lymphocytic infiltrate, basal melanin hyperpigmentation, and superficial dermal melanophages. We present a study on 2 biopsies from the arm and the thigh in a 77-year-old woman with a long clinical history of Addison disease as well as senile purpura and alopecia of female pattern. The patient presented diffuse hyperpigmentation of the skin, more pronounced on her face, and left upper forehead. Read More

    Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling.
    Heliyon 2017 May 30;3(5):e00309. Epub 2017 May 30.
    Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
    Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whether the wound healing-associated signaling milieu can be manipulated to protect against alopecia, such as chemotherapy-induced alopecia (CIA). Utilizing a well-established neonatal rat model of CIA, we show here that skin wounding protects from alopecia caused by several clinically relevant chemotherapeutic regimens, and that protection is dependent on the time of wounding and hair cycle stage. Read More

    Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.
    Proc Natl Acad Sci U S A 2017 Jun 12. Epub 2017 Jun 12.
    Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505;
    The recessive N-ethyl-N-nitrosourea-induced phenotype toku is characterized by delayed hair growth, progressive hair loss, and excessive accumulation of dermal cholesterol, triglycerides, and ceramides. The toku phenotype was attributed to a null allele of Gk5, encoding glycerol kinase 5 (GK5), a skin-specific kinase expressed predominantly in sebaceous glands. GK5 formed a complex with the sterol regulatory element-binding proteins (SREBPs) through their C-terminal regulatory domains, inhibiting SREBP processing and activation. Read More

    A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia.
    J Dermatolog Treat 2017 Jun 12:1-14. Epub 2017 Jun 12.
    a Department of Internal Medicine and Medical Specialties , "Sapienza", University of Rome , Italy.
    Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18-40 years old. Several molecules are commonly used for the treatment of AGA, acting on different steps of its pathogenesis (Minoxidil, Finasteride, Serenoa repens) and show some side effects. In literature, on the basis of hypertrichosis observed in patients treated with analogues of prostaglandin PGF2α, was supposed that prostaglandins would have an important role in the hair growth: PGE and PGF2α play a positive role, while PGD2 a negative one. Read More

    Severe hyperandrogenemia in postmenopausal woman as a presentation of ovarian hyperthecosis. Case report and mini review of the literature.
    Gynecol Endocrinol 2017 Jun 11:1-4. Epub 2017 Jun 11.
    a Department of Gynecological Endocrinology , Poznan University of Medical Sciences , Poznan , Poland.
    Ovarian hyperthecosis (OH) is characterized by the presence of abundant luteinized theca cells in ovaries that secret androgen. It typically presents as severe hyperandrogenism and/or virilization in postmenopausal woman. Here we describe a 66-year old woman with presentation of severe hirsutism, alopecia, clitoromegaly and laboratory finding of significantly elevated serum total testosterone concentration and hyperinsulinemia. Read More

    The impact of VDR expression and regulation in vivo.
    J Steroid Biochem Mol Biol 2017 Jun 9. Epub 2017 Jun 9.
    Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, United States. Electronic address:
    The vitamin D receptor (VDR) mediates the pleiotropic biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). These actions include orchestration of mineral homeostasis which is coordinated by the kidney, intestine, bone and parathyroid gland wherein the VDR transcriptionally regulates expression of the genes involved in this complex process. Mutations in human VDR (hVDR) cause hereditary vitamin D resistant rickets, a genetic syndrome characterized by hypocalcemia, hyperparathyroidism and rickets resulting from dysregulation of mineral homeostasis. Read More

    Ovarian cancer survivors' acceptance of treatment side effects evolves as goals of care change over the cancer continuum.
    Gynecol Oncol 2017 Jun 8. Epub 2017 Jun 8.
    Icahn School of Medicine at Mount Sinai, United States.
    Objectives: Women with ovarian cancer can have long overall survival and goals of treatment change over time from cure to remission to stable disease. We sought to determine whether survivors' acceptance of treatment side effects also changes over the disease continuum.

    Methods: Women with ovarian cancer completed an online survey focusing on survivors' goals and priorities. Read More

    Higher concentrations of dithranol appear to induce hair growth even in severe alopecia areata.
    Dermatol Ther 2017 Jun 9. Epub 2017 Jun 9.
    Division of Dermatology, Groote Schuur Hospital, University of Cape Town, South Africa.
    Alopecia areata (AA) is the commonest autoimmune cause of non-scarring alopecia. Topical treatments including corticosteroids and irritants maybe beneficial. Studies report variable hair regrowth with dithranol (anthralin) but all used low concentrations (0. Read More

    Clinical Signs, Pathophysiology and Management of Cutaneous Side Effects of Anti-Tumor Necrosis Factor Agents.
    Am J Clin Dermatol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Dermatology, Division of Dermato-Immunology, KU Leuven, University Hospital Sint-Rafaël, Kapucijnenvoer 33, 3000, Leuven, Belgium.
    Approximately one in four patients treated with anti-TNF agents (infliximab, etanercept, adalimumab, certolizumab, and golimumab) develops cutaneous adverse events, typically months to years after the initiation of treatment, with xerosis cutis, eczema (often psoriasiform), psoriasis, palmoplantar pustulosis, cutaneous infections, alopecia, and skin cancer being the most frequently encountered. The typical skin lesion of anti-tumor necrosis factor (TNF)-treated patients is orange-red psoriasiform eczema affecting the flexures, genitalia, scalp, or face, with high susceptibility to bacterial superinfection with Staphylococcus aureus. When adequate dermatological treatment is administered to patients with skin lesions receiving anti-TNF treatment, the discontinuation of anti-TNF agents is only rarely required. Read More

    Volumetric arc therapy for total scalp irradiation: case report for a recurrent basal cell carcinoma of the scalp.
    Ecancermedicalscience 2017 11;11:737. Epub 2017 May 11.
    Innovative Cancer Institute, 5995 SW 71st Street, South Miami, FL 33143, USA.
    Total scalp irradiation may be used to treat numerous conditions including squamous and basal cell carcinomas. These conditions are relatively uncommon and patients are frequently treated with palliative intent. In this report, we describe a volumetric arc therapy technique using photon beams for curative intent in an 84 years old patient with recurrent basal cell carcinoma of the scalp. Read More

    Cathepsin B as a potential cystatin M/E target in the mouse hair follicle.
    FASEB J 2017 Jun 8. Epub 2017 Jun 8.
    Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands;
    Deficiency of the cysteine protease inhibitor cystatin M/E (Cst6) in mice leads to disturbed epidermal cornification, impaired barrier function, and neonatal lethality. We report the rescue of the lethal skin phenotype of ichq (Cst6-deficient; Cst6(-/-)) mice by transgenic, epidermis-specific, reexpression of Cst6 under control of the human involucrin (INV) promoter. Rescued Tg(INV-Cst6)Cst6(ichq/ichq) mice survive the neonatal phase, but display severe eye pathology and alopecia after 4 mo. Read More

    Phase I study of oral ridaforolimus in combination with paclitaxel and carboplatin in patients with solid tumor cancers.
    BMC Cancer 2017 Jun 8;17(1):407. Epub 2017 Jun 8.
    Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33647, USA.
    Background: Ridaforolimus is a mammalian target of rapamycin inhibitor that has activity in solid tumors. Paclitaxel and carboplatin have broad antineoplastic activity in many cancers. This phase I trial was conducted to determine the safety profile, maximal tolerated dose, and recommended phase II dose and schedule of oral ridaforolimus combined with paclitaxel and carboplatin in patients with solid tumor cancers. Read More

    An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia.
    Cell Cycle 2017 Jun 8. Epub 2017 Jun 8.
    f Insilico Medicine, Inc., Emerging Technology Centers, Johns Hopkins University at Eastern , B301, 1101 33rd Street, Baltimore , MD , 21218 , USA.
    Androgenetic alopecia is the most common form of hair loss. Minoxidil has been approved for the treatment of hair loss, however its mechanism of action is still not fully clarified. In this study, we aimed to elucidate the effects of 5% minoxidil topical foam on gene expression and activation of signaling pathways in vertex and frontal scalp of men with androgenetic alopecia. Read More

    Aging in hair follicle stem cells and niche microenvironment.
    J Dermatol 2017 Jun 8. Epub 2017 Jun 8.
    Institute of Medical Biology, Agency for Science, Technology and Research, Singapore.
    Hair graying and hair loss are prominent and common characteristics of the elderly population. In some individuals these processes can significantly impact their quality of life, leading to depression, anxiety and other serious mental health problems. Accordingly, there has been much interest in understanding the complex physiological changes within the hair follicle in the aging individual. Read More

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