21,103 results match your criteria Scarring Alopecia


The effect of atorvastatin on cardiometabolic risk factors in women with non-classic congenital adrenal hyperplasia: A pilot study.

Pharmacol Rep 2019 Jan 31;71(3):417-421. Epub 2019 Jan 31.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Background: Individuals with non-classic congenital adrenal hyperplasia (NC-CAH) often show evidence of hyperandrogenism, including premature pubarche, accelerated linear growth velocity, short final height, hirsutism, acne, alopecia, impaired ovulation, menstrual dysfunction and subfertility. Although statins were found to reduce elevated levels of androgens in subjects with this disorder, no previous study has investigated whether 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors affect cardiometabolic risk factors in patients with NC-CAH.

Methods: We studied 12 women with NC-CAH, 6 of whom because of coexisting hypercholesterolemia received atorvastatin (20-40 mg daily). Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.014DOI Listing
January 2019

Dupilumab and Alopecia: Causative or Therapeutic?

Dermatology 2019 Apr 18:1-2. Epub 2019 Apr 18.

Division of Dermatology, University of Arizona Department of Medicine, Tucson, Arizona, USA,

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http://dx.doi.org/10.1159/000499080DOI Listing

The efficacy and safety of targeted narrowband UVB therapy: a retrospective cohort study

Turk J Med Sci 2019 Apr 18;49(2):595-603. Epub 2019 Apr 18.

Background/aim: Phototherapy is a safe and effective treatment modality for numerous dermatological conditions. Recently, targeted phototherapy modalities have gained importance due to their advantages over conventional phototherapy.This retrospective study aimed to evaluate the safety and efficacy of targeted narrowband UVB phototherapy in patients with dermatological disorders

Materials And Methods: This single-center study included 173 patients who were treated with targeted narrowband UVB phototherapy. Read More

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http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=s
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http://dx.doi.org/10.3906/sag-1810-110DOI Listing
April 2019
1 Read

Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment.

Int J Womens Dermatol 2019 Jun 23;5(2):116-123. Epub 2019 Jan 23.

Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Frontal fibrosing alopecia (FFA) is a relatively new scarring alopecia that is considered a variant of lichen planopilaris (LPP) with no recognized promising treatments. In this study, we tried to clarify the underlying signaling pathways and their roles in the pathogenesis and progression of FFA. Because of several differences in clinical manifestations, response to treatments, and pathological findings, these two conditions could be differentiated from each other. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23526475183007
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http://dx.doi.org/10.1016/j.ijwd.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451751PMC
June 2019
1 Read

A systematic simulation-based meta-analytical framework for prediction of physiological biomarkers in alopecia.

J Biol Res (Thessalon) 2019 Dec 4;26. Epub 2019 Apr 4.

5Informatics Institute, School of Medicine, The University of Alabama (UAB), Birmingham, USA.

Background: Alopecia or hair loss is a complex polygenetic and psychologically devastating disease affecting millions of men and women globally. Since the gene annotation and environmental knowledge is limited for alopecia, a systematic analysis for the identification of candidate biomarkers is required that could provide potential therapeutic targets for hair loss therapy.

Results: We designed an interactive framework to perform a meta-analytical study based on differential expression analysis, systems biology, and functional proteomic investigations. Read More

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http://dx.doi.org/10.1186/s40709-019-0094-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449998PMC
December 2019

Living with systemic lupus erythematosus in South Africa: a bitter pill to swallow.

Health Qual Life Outcomes 2019 Apr 16;17(1):65. Epub 2019 Apr 16.

Rheumatic Disease Unit, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Background: Systemic lupus erythematosus (SLE) often has a profound negative impact on health-related quality of life (HRQoL). In the absence of any qualitative studies in sub-Saharan Africa, we undertook a study to explore living experiences, perceptions and unmet needs of South African patients with SLE.

Methods: Twenty-five women with SLE consented to participate in the study. Read More

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https://hqlo.biomedcentral.com/articles/10.1186/s12955-019-1
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http://dx.doi.org/10.1186/s12955-019-1132-yDOI Listing
April 2019
1 Read

Regulatory T-Cells in alopecia areata.

J Cutan Pathol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology, Loyola University Medical Center, Maywood, IL.

Introduction: Alopecia areata (AA) is believed to have an autoimmune mechanism in which the hair follicles are targeted by CD4+ and CD8+ lymphocytes. Studies investigating the autoimmune mechanism of other cutaneous diseases, including vitiligo, demonstrated that Treg are a component of cutaneous immune privilege. Our study uses immunohistochemical staining in formalin-fixed, paraffin embedded tissue to examine the percentage of CD4+FoxP3+, CD25+FoxP3+ and CD8+FoxP3+ Treg in AA in human specimens. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13479
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http://dx.doi.org/10.1111/cup.13479DOI Listing
April 2019
1 Read

Dietary Protein Deficit and Deregulated Autophagy: A New Clinico-diagnostic Perspective in Pathogenesis of Early Aging, Skin, and Hair Disorders.

Indian Dermatol Online J 2019 Mar-Apr;10(2):115-124

Department of Dermatology, Aesthetic Surgery and Intervention Dermatology, AURA Skin Institute, Chandigarh, India.

Background: Diet has an important role to play in the well-being of human body.

Aims: The study intends to establish the "hypothesis of conscious, selective, and self-destruction i.e. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_123_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434747PMC
April 2019
4 Reads

Update on Management of Polycystic Ovarian Syndrome for Dermatologists.

Indian Dermatol Online J 2019 Mar-Apr;10(2):97-105

Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Polycystic ovarian syndrome (PCOS) is the commonest endocrine disorder in women having wide range of clinical manifestation. These women may present with reproductive, dermatological, metabolic, psychological, or neoplastic implications from adolescence to menopause. The common dermatological manifestations include hirsutism, acne, alopecia, or acanthosis nigricans. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_249_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434760PMC

Dermatopathia Pigmentosa Reticularis.

Indian J Dermatol 2019 Mar-Apr;64(2):149-151

Department of Dermatology, Medical College, Kolkata, West Bengal, India.

Dermatopathia pigmentosa reticularis is a rare ectodermal dysplasia that presents with a triad of reticulate hyperpigmentation, nonscarring alopecia, and nail dystrophy. We report herein a case of a 23-year-old male presenting with the characteristic triad associated with anhidrosis and palmoplantar keratoderma. Read More

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http://dx.doi.org/10.4103/ijd.IJD_401_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440173PMC

Identification of blood microRNA alterations in patients with severe active alopecia areata.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Alopecia areata (AA) is a common inflammatory disease characterized by cellular infiltration of T cells targeting the anagen-stage hair follicle. Lack of efficacious treatment for AA may be due to little knowledge about its exact cellular mechanism. Studies have demonstrated that microRNAs (miRNAs) play an important role in the regulation of inflammatory skin diseases such as atopic dermatitis and psoriasis. Read More

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http://dx.doi.org/10.1002/jcb.28700DOI Listing
April 2019
4 Reads

A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia.

Lasers Med Sci 2019 Apr 13. Epub 2019 Apr 13.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.

Fractional 1550-nm erbium-glass (Er:Glass) laser therapy is effective in inducing hair regrowth. Combining fractional Er:Glass laser therapy with topical minoxidil may yield therapeutic benefits for patients with androgenetic alopecia (AGA). To compare the efficacy and safety of fractional Er:Glass laser used in combination with topical 5% minoxidil versus 5% minoxidil alone for the treatment of male AGA, 30 men with AGA were randomized to 24 weeks of split-scalp treatment using fractional Er:Glass laser and 5% minoxidil on one side (combined therapy) or 5% minoxidil alone on the other side (monotherapy). Read More

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http://dx.doi.org/10.1007/s10103-019-02783-8DOI Listing

Risk of valproic acid-related alopecia: A systematic review and meta-analysis.

Seizure 2019 Apr 5;69:61-69. Epub 2019 Apr 5.

Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China. Electronic address:

Purpose: We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing valproic acid (VPA) therapy.

Methods: We retrieved relevant publications and gathered data on alopecia in patients taking VPA and other drugs from prospective studies.

Results: Twenty-five articles met the inclusion criteria, and the overall incidence of alopecia in patients receiving VPA therapy was 11% (95% confidence interval (CI): 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311193005
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http://dx.doi.org/10.1016/j.seizure.2019.04.003DOI Listing
April 2019
2 Reads

Tinea Capitis in Adults; A 18-year Retrospective, Single Centre Study in Korea.

Mycoses 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea.

Background: Tinea capitis (TC) is a dermatophyte infection involving hair and scalp and occurs primarily in prepubertal children. However, data on adults are limited.

Objectives: The aim of this study is to evaluate epidemiological, clinical, and mycological characteristics of TC in adults in Korea. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/myc.12916
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http://dx.doi.org/10.1111/myc.12916DOI Listing
April 2019
1 Read

Alopecia areata is characterised by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease-associated psychological morbidity.

Br J Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.

Background: Alopecia areata (AA) is a common autoimmune disease, causing patchy hair loss that can progress to involve the entire scalp (totalis) or body (universalis). CD8 NKG2D T cells dominate hair follicle pathogenesis, but the specific mechanisms driving hair loss are not fully understood.

Objectives: To provide a detailed insight into the systemic cytokine signature associated with AA, and assess the association between cytokines and depression. Read More

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http://dx.doi.org/10.1111/bjd.18008DOI Listing
April 2019
1 Read

An overview of herbal alternatives in androgenetic alopecia.

J Cosmet Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Dr. Bhanuben, Nanavati College of Pharmacy, Mumbai, India.

The second most common alopecia-Androgenetic alopecia (AGA)-occurs due to hormonal imbalance. Dihydrotestosterone (DHT) an androgenic hormone is a sex steroid, produced in the gonads. The target sites of DHT are similar to that of testosterone, and it attaches easily remaining bound for 53 minutes as compared to 35 minutes of testosterone. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12930
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http://dx.doi.org/10.1111/jocd.12930DOI Listing
April 2019
2 Reads

Manuscript No 19-00107 Frontal Fibrosing Alopecia, Just Lichen Planopilaris?

Authors:
Steven Kossard

J Am Acad Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Kossard Dermatopathologists, Macquarie Park, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.02.072DOI Listing
April 2019
6 Reads

Frontal fibrosing alopecia should be renamed to lichen planopilaris of Kossard.

J Am Acad Dermatol 2019 Apr 9. Epub 2019 Apr 9.

St. John's Institute of Dermatology, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1016/j.jaad.2019.03.090DOI Listing
April 2019
1 Read

An urticarial drug eruption caused by tofacitinib for alopecia universalis.

Dermatol Ther 2019 Apr 12:e12933. Epub 2019 Apr 12.

Department of Dermatology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia 3050.

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http://dx.doi.org/10.1111/dth.12933DOI Listing
April 2019
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The role of the microbiome in scalp hair follicle biology and disease.

Exp Dermatol 2019 Apr 11. Epub 2019 Apr 11.

Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin corporate member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin and Berlin Institute of Health, Germany.

The skin surface microbiome and its role in skin diseases have received increasing attention over the past years. Beyond, there is evidence for a continuous exchange with the cutaneous immune system in healthy skin, where hair follicles provide unique anatomical niches. Especially scalp hair follicles form large tubular invaginations, which extend deeply into the skin and harbor a variety of microorganisms. Read More

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http://dx.doi.org/10.1111/exd.13935DOI Listing
April 2019
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Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Up-Regulating Follicular Sulfotransferase Enzymes.

Dermatol Ther 2019 Apr 11:e12915. Epub 2019 Apr 11.

Applied Biology, California, USA.

Minoxidil sulfate is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil. For hair growth, sulfotransferase enzymes expressed in outer root sheath of the hair follicle sulfonate minoxidil. The large intra-subject variability in follicular sulfotransferase was found to predict minoxidil response and thus explain the low response rate to topical minoxidil in the treatment of androgenetic alopecia. Read More

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http://dx.doi.org/10.1111/dth.12915DOI Listing
April 2019
1.478 Impact Factor

Scalp bacterial shift in Alopecia areata.

PLoS One 2019 11;14(4):e0215206. Epub 2019 Apr 11.

Giuliani SpA, Milan, Italy.

The role of microbial dysbiosis in scalp disease has been recently hypothesized. However, little information is available with regards to the association between microbial population on the scalp and hair diseases related to hair growth. Here we investigated bacterial communities in healthy and Alopecia areata (AA) subjects. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215206PLOS
April 2019
2 Reads

Investigating the beneficial experiences of online peer support for those affected by alopecia: An interpretative phenomenological analysis using online interviews.

Br J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Psychology, University of Sheffield, Cathedral Court, 1 Vicar Lane, Sheffield, UK.

Background: Those affected by alopecia are at risk of experiencing a range of psychosocial consequences. Alopecia UK provide online peer support via facilitated Facebook pages. Online peer support has been found to provide a variety of benefits in other long term conditions, such as providing information and emotional support. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17998
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http://dx.doi.org/10.1111/bjd.17998DOI Listing
April 2019
3 Reads

Effects of Pregnancy, Outdoor Access, and Antifungal Medication on Hair Loss in Breeding-age Female Pigtailed Macaques (Macaca nemestrina).

Comp Med 2019 Apr 10. Epub 2019 Apr 10.

Over 18 mo, adult female pigtailed macaques (Macaca nemestrina) housed at a breeding facility in Arizona were monitoredevery 6 mo for alopecia. The study period coincided with the movement of a majority of animals from primarily outdoor housing to continuous indoor housing and a corresponding decrease in available space. These changes were made due to the newly recognized prevalence of coccidioidomycosis at this site. Read More

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http://dx.doi.org/10.30802/AALAS-CM-18-000108DOI Listing
April 2019
1 Read

Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, a Lower Self-Esteem, and a Lower Quality of Life.

Neuropsychobiology 2019 Apr 10:1-9. Epub 2019 Apr 10.

Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric Clinics (UPK), University of Basel, Basel, Switzerland,

Background: Individuals with lichen planopilaris (LPP) typically present with hair loss and an irritated scalp, with signs and symptoms such as itching, erythema, scaling, and burning. Both hair loss and reddened skin may be visible also for other people. Therefore, it is conceivable that individuals with LPP might report a lower mental health status. Read More

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http://dx.doi.org/10.1159/000499135DOI Listing
April 2019
2 Reads
2.261 Impact Factor

Predictive factors of response to pulse methylprednisolone therapy in patients with alopecia areata: A follow-up study of 105 Japanese patients.

J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Pulse corticosteroid therapy is effective for alopecia areata (AA) in the early stage. The risk and efficacy of this therapy for patients with several backgrounds, however, remains controversial. To explore the predictive factors of the response and risk factors of this therapy, data from 105 AA patients treated with methylprednisolone (500 mg) i. Read More

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http://dx.doi.org/10.1111/1346-8138.14871DOI Listing
April 2019
2 Reads

Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis: Intrafamilial overlap of phenotypes in patients with the same KRT14 frameshift variant.

Br J Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Biomedicine, University Hospital Basel and University of Basel, Switzerland.

Naegeli-Franceschetti-Jadassohn syndrome (NFJS, OMIM #161000) and dermatopathia pigmentosa reticularis (DPR, OMIM #125595) have been defined as separate ectodermal dysplasias. Only 55 patients from nine families with NFJS and 21 patients with DPR have been published in literature. Common to both diseases are an an- or hypohidrosis as well as a reticular pattern of hyperpigmentation of the skin (Table 1). Read More

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http://dx.doi.org/10.1111/bjd.17997DOI Listing
April 2019
1 Read

Familial Vitamin D-dependent rickets Type 2A: A report of two cases with alopecia and oral manifestations.

Authors:
Moni Thakur

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):130-133

Department of Oral and Maxillofacial Pathology, Mamata Dental College and Hospital, Khammam, Telangana, India.

Rickets is a metabolic bone disease that develops as a result of inadequate mineralization of growing bone due to disruption of calcium, phosphorus and/or Vitamin D metabolism. In addition, several rare genetic causes of rickets have also been described, which can be divided into two groups. The first group consists of genetic disorders of Vitamin D biosynthesis and action, such as Vitamin D-dependent rickets Type 1A, Type 1B, Type 2A (VDDR2A) and Type 2B. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_309_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421925PMC
February 2019
1 Read

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Re-Growth in Androgenetic Alopecia. Biomolecular Pathway Analysis and Clinical Evaluation.

Biomedicines 2019 Apr 8;7(2). Epub 2019 Apr 8.

Institute of Dermatology, F. Policlinico Gemelli, IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Platelet rich plasma (PRP) and Micrografts containing human follicle mesenchymal stem cells (HF-MSCs) were tried as a potential treatment for androgenetic alopecia (AGA). However, little to no work has yet to be seen wherein the bio-molecular pathway of HF-MSCs or PRP treatments were analyzed. The aims of this work are to report the clinical effectiveness of HF-MSCs and platelet-rich plasma evaluating and reviewing the most updated information related to the bio-molecular pathway. Read More

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https://www.mdpi.com/2227-9059/7/2/27
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http://dx.doi.org/10.3390/biomedicines7020027DOI Listing
April 2019
2 Reads

JAK/STAT pathway modulation: Does it work in Dermatology?

Authors:
Özgür Gündüz

Dermatol Ther 2019 Apr 9:e12903. Epub 2019 Apr 9.

Kirikkale University Faculty of Medicine, Department of Dermatology and Venerology, Yenisehir District, Tahsin Duru Avenue, No:14, 71450, Yahsihan / Kirikkale, Turkey.

JAK/STAT is an intracellular signaling pathway, which plays a key role in downstream transmission of extracellular signals from cell membrane to the cell nucleus. This pathway is activated by cytokines, which participate in inflammation, innate and acquired immune responses, and also cell growth. Recent studies point out possible disturbances in JAK/STAT pathway in various inflammatory and autoimmune skin diseases, such as atopic dermatitis, psoriasis, alopecia areata. Read More

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http://dx.doi.org/10.1111/dth.12903DOI Listing

Generalized hypertrichosis due to secukinumab in a patient with moderate psoriasis: A case of serendipity or zemblanity?

Dermatol Ther 2019 Apr 8:e12894. Epub 2019 Apr 8.

Division of Dermatology, Department of Specialized, Clinical and Experimental Medicine, University of Bologna, Bologna, Italy.

After 4 months of therapy with secukinumab, a 67-year-old man with moderate psoriasis developed generalized hypertrichosis, along with PASI 90. The patient denied any drug intake, apart from secukinumab, nor applications of any creams. Moreover, this event did not really bother the patient, thus the therapy was not discontinued and the hypertrichosis is persisting as psoriasis' control. Read More

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http://dx.doi.org/10.1111/dth.12894DOI Listing
April 2019
1 Read

Jaundice and anaemia as presenting features of an incomplete autoimmune polyglandular syndrome type II.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Department of General Medicine, R.G. Kar Medical College and Hospital, Kolkata, India.

The coexistence of adrenal failure with either autoimmune thyroid disease and/or type 1 diabetes is defined as autoimmune polyglandular syndrome (APS) type 2 or Schmidt's syndrome. Vitiligo, hypergonadotropic hypogonadism, chronic autoimmune hepatitis, alopecia, pernicious anaemia and seronegative arthritis may also be present. We present a case of 45-year-old Indian man with progressive jaundice and asthenia for 3 months. Read More

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http://dx.doi.org/10.1136/bcr-2018-228490DOI Listing
April 2019
1 Read

Assessing the correlation between trichoscopic features in lichen planopilaris and lichen planopilaris activity index.

Australas J Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background/objectives: Videodermoscopy is a valuable tool for the diagnosis of cicatricial alopecias such as lichen planopilaris. Lichen planopilaris activity index is used for evaluating lichen planopilaris severity. Our aim was to examine the utility of videodermoscopy in the assessment of lichen planopilaris severity. Read More

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http://dx.doi.org/10.1111/ajd.13022DOI Listing
April 2019
2 Reads

Confluent and Reticulated Papillomatosis Associated with Polycystic Ovarian Syndrome.

Cureus 2019 Jan 25;11(1):e3956. Epub 2019 Jan 25.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Polycystic ovarian syndrome is an endocrine disorder diagnosed commonly in young women. Various cutaneous manifestations can include acanthosis nigricans, acne, hirsutism, and alopecia. Confluent and reticulated papillomatosis is a rare skin condition that may be associated with polycystic ovarian syndrome. Read More

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http://dx.doi.org/10.7759/cureus.3956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436673PMC
January 2019
1 Read

Medical Therapy for Frontal Fibrosing Alopecia: A Review and Clinical Approach.

J Am Acad Dermatol 2019 Apr 3. Epub 2019 Apr 3.

The Ronald O. Perelman Department of Dermatology, New York University, New York, New York 10016. Electronic address:

Background: Guidelines for the treatment of frontal fibrosing alopecia (FFA) are limited and literature on treatment modalities consists mostly of case reports and cohort studies.

Objectives: In this review, we sought to assess the response of medical therapy for FFA and propose a clinical approach to management.

Methods: A literature search for "frontal fibrosing alopecia" on PubMed returned 270 items. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.079DOI Listing
April 2019
2 Reads

Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity.

PLoS One 2019 4;14(4):e0214621. Epub 2019 Apr 4.

Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.

Experimental non-human primate models of obesity are induced through the introduction of atypically calorically rich diets. Studies in captive-bred macaques show the development of obesity and diabetes with similar complications to humans including eye and kidney diseases, nerve damage associated with pain and blood vessel damage. Diets differ in outcomes and here we document inflammation of the gastrointestinal tract that can be exacerbated through these dietary interventions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214621PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448857PMC
April 2019
4 Reads

Hypopigmented Macules as Manifestation of Lichen Planus and Lichen Planopilaris.

Am J Dermatopathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.

Lichen planus (LP) is an idiopathic inflammatory disease of the skin, hair, nails, and mucous membranes. Classic cutaneous LP is characterized by violaceous flat-topped papules that typically favor the extremities. LP on the scalp, otherwise known as lichen planopilaris, classically presents with scarring alopecia, perifollicular erythema and follicular prominence. Read More

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http://Insights.ovid.com/crossref?an=00000372-900000000-9816
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http://dx.doi.org/10.1097/DAD.0000000000001389DOI Listing
March 2019
6 Reads

Long-term treatment with finasteride induces apoptosis and pathological changes in female mice.

Hum Exp Toxicol 2019 Apr 3:960327119842195. Epub 2019 Apr 3.

1 Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Androgenetic alopecia is the most common type of alopecia, and it affects humans of both genders. Finasteride is a type II selective 5α-reductase inhibitor that is administered orally to treat androgenetic alopecia and benign prostatic hyperplasia in human males. However, its effect on the vital organs of females is unknown. Read More

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http://dx.doi.org/10.1177/0960327119842195DOI Listing
April 2019
3 Reads

A Dose-Escalating Pilot Study (NCT03017404) of Pegylated Liposomal Doxorubicin and Cyclophosphamide, Followed by Docetaxel Administration as a Neoadjuvant Chemotherapy Regimen in Patients with Locally Advanced Breast Cancer.

Oncol Res Treat 2019 Apr 3:1-6. Epub 2019 Apr 3.

Office of Clinical Trials, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Pegylated liposomal doxorubicin (PEG-LD) has a comparable efficacy but a distinct toxicological profile compared with free doxorubicin. The use of PEG-LD and cyclophosphamide followed by docetaxel regimen as neoadjuvant chemotherapy has not been well established.

Objectives: We aimed to assess the maximum tolerated dose (MTD) and toxicity of this regimen in patients with locally advanced breast cancer. Read More

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http://dx.doi.org/10.1159/000498993DOI Listing
April 2019
6 Reads

Case of alopecia areata during dupilumab treatment for atopic dermatitis.

J Dermatol 2019 Apr 3. Epub 2019 Apr 3.

Department of Dermatology, Nippon Medical School, Tokyo, Japan.

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http://dx.doi.org/10.1111/1346-8138.14880DOI Listing
April 2019
6 Reads

Development of finasteride polymer microspheres for systemic application in androgenic alopecia.

Int J Mol Med 2019 Mar 28. Epub 2019 Mar 28.

KNU‑Center for Nonlinear Dynamics, CMRI, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Science Kyungpook National University, Daegu 41566, Republic of Korea.

The use of finasteride for alleviating hair loss has been investigated, and it has been applied as an oral dose medication. However, due to the inconvenience of daily drug administration over long period of time, novel controllable finasteride delivery has been actively investigated. As a novel method of finasteride delivery, the development of finasteride‑loaded microspheres for subcutaneous administration is becoming increasingly pharmaceutically important. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4149DOI Listing
March 2019
2 Reads

Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in .

Front Immunol 2019 19;10:297. Epub 2019 Mar 19.

Faculty of Medicine, Center for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg, Freiburg, Germany.

Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations in have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, a rare condition combining deficiency of anterior pituitary hormone with CVID. Here, we investigate 15 previously unreported patients with primary immunodeficiency (PID) from eleven unrelated families with heterozygous -mutations including eight patients with the common p. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435015PMC
March 2019
10 Reads

Reversible alopecia associated with high blood mercury levels and early menopause: a report of two cases.

Menopause 2019 Apr 1. Epub 2019 Apr 1.

The Center for Menopause, Hormonal Disorders & Women's Health, New York, NY.

Objective: The aim of this study was to report on two women in early menopause with alopecia and high mercury (Hg) levels which reversed with a decrease in toxic levels.

Methods: Retrospective chart review and case studies in a reproductive endocrinology practice.

Results: A 43-year-old woman initially evaluated for early menopause later experienced sudden circumscribed hair loss on the scalp. Read More

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http://dx.doi.org/10.1097/GME.0000000000001332DOI Listing
April 2019
2 Reads

Dupilumab Improved Alopecia Areata in a Patient with Atopic Dermatitis: A Case Report.

Acta Derm Venereol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-k, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.2340/00015555-3183DOI Listing
April 2019
4 Reads

Low-dose cyclosporine for active lupus nephritis: a dose titration approach.

Clin Rheumatol 2019 Apr 1. Epub 2019 Apr 1.

Nephrology Unit, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Rajavithi Road, Bangkok, 10400, Thailand.

Objective: Achievement of complete renal remission (CR) is an important goal in lupus nephritis (LN) treatment. The use of cyclosporine (CsA) for active LN has been challenged because of variations in CsA doses and reports of adverse reactions (AR).

Method: A cohort of 62 patients with active LN (induction-resistant LN and flared LN) who were treated with CsA was evaluated. Read More

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http://dx.doi.org/10.1007/s10067-019-04469-6DOI Listing
April 2019
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Off-label studies on apremilast in dermatology: a review.

J Dermatolog Treat 2019 Apr 2:1-10. Epub 2019 Apr 2.

a Division of Dermatology, Department of Medicine , David Geffen School of Medicine at UCLA , Los Angeles , CA , USA.

Purpose: Apremilast is a phosphodiesterase-4 inhibitor FDA approved for psoriatic arthritis and moderate to severe plaque psoriasis. In recent years, multiple studies have suggested other potential uses for apremilast in dermatology. A summary of these various studies will be a valuable aid to dermatologists considering apremilast for an alternative indication. Read More

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http://dx.doi.org/10.1080/09546634.2019.1589641DOI Listing
April 2019
5 Reads

The use of phosphodiesterase inhibitors for the treatment of alopecia.

J Dermatolog Treat 2019 Apr 2:1-8. Epub 2019 Apr 2.

a Department of Dermatology , University of California Irvine, Irvine , CA , USA.

Background: Hair loss encompasses a group of scarring and nonscarring diseases with limited treatment options. Understanding the pathogenesis of alopecias has led to the experimental use of phosphodiesterase inhibitors (PDEi).

Objective: To perform a systematic review of literature surrounding the use of PDEi for alopecia. Read More

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http://dx.doi.org/10.1080/09546634.2019.1592097DOI Listing
April 2019
4 Reads