3,019 results match your criteria Scarlet Fever

Decreased Antibiotic Consumption Coincided with Reduction in Bacteremia Caused by Bacterial Species with Respiratory Transmission Potential during the COVID-19 Pandemic.

Antibiotics (Basel) 2022 May 31;11(6). Epub 2022 May 31.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Nonpharmaceutical interventions implemented during the COVID-19 pandemic (2020-2021) have provided a unique opportunity to understand their impact on the wholesale supply of antibiotics and incidences of infections represented by bacteremia due to common bacterial species in Hong Kong. The wholesale antibiotic supply data (surrogate indicator of antibiotic consumption) and notifications of scarlet fever, chickenpox, and tuberculosis collected by the Centre for Health Protection, and the data of blood cultures of patients admitted to public hospitals in Hong Kong collected by the Hospital Authority for the last 10 years, were tabulated and analyzed. A reduction in the wholesale supply of antibiotics was observed. Read More

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The indirect impact of control measures in COVID-19 pandemic on the incidence of other infectious diseases in China.

Public Health Pract (Oxf) 2022 Dec 13;4:100278. Epub 2022 Jun 13.

Infectious Diseases Department, Jinan Children's Hospital: Children's Hospital Affiliated to Shandong University, No. 23976 Jingshi Road, Jinan, 250022, Jinan, China.

Objectives: During COVID-19 pandemic in 2020, China, some public health measures of forced lockdown, closure of school and public meeting places, staying at home, transportation stop, masks wearing, hands washing, environmental disinfection were taken on to control epidemic transmission, these measures have made indirect affect on the other infectious diseases incidence.

Study Design: During COVID-19 pandemic in 2020, we retrospectively analyzed and compared reported cases of other infectious diseases,in order to found what impact of measures in controlling COVID-19 pandemic on the other infectious diseases in China.

Methods: We retrospectively analyzed and compared reported cases of measles, pertussis, scarlet fever, seasonal influenza, mumps, HFMD each month in 2018, 2019 and 2020 from the National Health Commission, PRC. Read More

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December 2022

[Demographics of war: mortality in Porto Alegre during Guerra dos Farrapos, 1835-1845].

Hist Cienc Saude Manguinhos 2022 Apr-Jun;29(2):399-419

Pesquisador independente, doutor em Demografia pelo Programa de Pós-graduação em Demografia/Universidade Estadual de Campinas. Campinas - SP - Brasil

This article presents an analysis of the impacts of the Guerra dos Farrapos (1835-1845) on the mortality of the population of Porto Alegre, drawing primarily on baptism and death records, comparing the periods before and after the conflict, ranging from 1825 to 1854. Anomalies can be noted in the first five years of the war, when the city was under siege from the rebels. The results, based on a calculation of infant mortality and other indicators, show not only that there were supply difficulties and deteriorated sanitary conditions, but also that mortality levels surged in response to a scarlet fever epidemic, which hit free and enslaved children particularly hard. Read More

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Distribution of emm genotypes in group A streptococcus isolates of Korean children from 2012 to 2019.

J Microbiol Immunol Infect 2022 May 17. Epub 2022 May 17.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address:

Objectives: Changes in the epidemiology of group A streptococcus (GAS) infection is related to emm genotype. We studied the distribution of emm genotypes and their antibiotic susceptibility among Korean children.

Methods: Isolates from children with GAS infection between 2012 and 2019 were collected. Read More

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Prevalence and identification of antibiotic-resistant scarlet fever group A Streptococcus strains in some pediatric cases at Shenzhen, China.

J Glob Antimicrob Resist 2022 May 23. Epub 2022 May 23.

Division of Laboratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China; Medical Technology School of Xuzhou Medical University, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou 221004, China. Electronic address:

Objective: This study aimed to investigate the annual incidence, molecular epidemiological characteristics, and antimicrobial resistance of group A Streptococcus (GAS) clinical isolates from pediatric patients at Shenzhen Children's Hospital during 2016-2020.

Methods: Clinical samples were collected from pediatric patients with a suspected diagnosis of GAS infections. We studied the annual incidence and characteristics of GAS infections using the GAS antigen detection method. Read More

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Characterization of group A beta-haemolytic streptococcus with mucoid phenotype isolated in a tertiary hospital.

Enferm Infecc Microbiol Clin (Engl Ed) 2022 May 12. Epub 2022 May 12.

Unidad de Gestión Clínica de Microbiología, Hospital Universitario Reina Sofía, Córdoba, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba, Córdoba, Spain; Departamento de Química Agrícola, Edafología y Microbiología, Universidad de Córdoba, Córdoba, Spain.

Introduction: The objective of this study is to characterize Streptococcus pyogenes isolates with a mucoid phenotype and to compare them with non-mucoid isolates obtained between April and August 2016.

Material And Methods: Identification and antimicrobial susceptibility were performed in all isolates. The emm type and exotoxin genes speA, speB, speC, speF, speG, speH, speJ, speZ and ssa were analyzed. Read More

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A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study.

Lancet Microbe 2021 07 15;2(7):e291-e299. Epub 2021 Apr 15.

Tropical Diseases Research Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia; Infectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Melbourne, VIC, Australia.

Background: Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concept evaluation of candidate vaccines. We describe the initial Controlled Human Infection for Vaccination Against S pyogenes (CHIVAS-M75) study, in which we aimed to identify a dose of emm75 S pyogenes that causes acute pharyngitis in at least 60% of volunteers when applied to the pharynx by swab. Read More

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Frequency of transmission, asymptomatic shedding, and airborne spread of Streptococcus pyogenes in schoolchildren exposed to scarlet fever: a prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in England, UK.

Lancet Microbe 2022 May 10;3(5):e366-e375. Epub 2022 Mar 10.

Department of Infectious Disease, Imperial College London, London, UK; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK; MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK. Electronic address:

Background: Despite recommendations regarding prompt treatment of cases and enhanced hygiene measures, scarlet fever outbreaks increased in England between 2014 and 2018. We aimed to assess the effects of standard interventions on transmission of Streptococcus pyogenes to classroom contacts, households, and classroom environments to inform future guidance.

Methods: We did a prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in six settings across five schools in Greater London, UK. Read More

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Forecasting the monthly incidence of scarlet fever in Chongqing, China using the SARIMA model.

Epidemiol Infect 2022 04 21;150:e90. Epub 2022 Apr 21.

Chongqing Center of Disease Control and Prevention, Chongqing400042, China.

The incidence of scarlet fever has increased dramatically in recent years in Chongqing, China, but there has no effective method to forecast it. This study aimed to develop a forecasting model of the incidence of scarlet fever using a seasonal autoregressive integrated moving average (SARIMA) model. Monthly scarlet fever data between 2011 and 2019 in Chongqing, China were retrieved from the Notifiable Infectious Disease Surveillance System. Read More

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The secondary outcome of public health measures amidst the COVID-19 pandemic in the spread of other respiratory infectious diseases in Thailand.

Travel Med Infect Dis 2022 Jul-Aug;48:102348. Epub 2022 May 4.

Faculty of Medical Technology Huachiew Chalermprakiet University, Samut Prakan, 10540, Thailand.

The coronavirus disease 2019 (COVID-19) has promoted stringent public health measures such as hand hygiene, face mask wearing, and physical distancing to contain the spread of the viral infection. In this retrospective study, the secondary outcomes of those public health measures on containing other respiratory infections among the Thai population were investigated. Hospitalization data spanning from 2016 to 2021 of six respiratory infectious diseases, namely influenza, measles, pertussis, pneumonia, scarlet fever, and tuberculosis (TB), were examined. Read More

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Modeling the effects of air pollutants and meteorological factors on scarlet fever in five provinces, Northwest China, 2013-2018.

J Theor Biol 2022 Jul 22;544:111134. Epub 2022 Apr 22.

Department of Applied Mathematics, Lanzhou University of Technology, Lanzhou, Gansu 730050, People's Republic of China. Electronic address:

As a common infectious disease, scarlet fever has exposed a tendency of slow fluctuating ups and downs in recent years with a certain periodicity. In this work, a novel differential equation epidemic model with freely transmitted viruses is introduced to investigate the transmission dynamics of scarlet fever in Northwest China. First, the correlation analysis reveals that the incidence rate of scarlet fever is significantly positively correlated with air pressure (r = 0. Read More

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Rash, red eyes, lip erosions and genital ulcer - What is the diagnosis?

Malays Fam Physician 2022 Mar 28;17(1):99-102. Epub 2022 Mar 28.

MBBS (IMU), MRCP (UK), Department of Dermatology, Hospital Pakar Sultanah Fatimah, Muar, Johor, Malaysia, Email:

Maculopapular eruptions are frequently described as large areas of rash characterised by red, small, confluent bumps. They are frequently puzzling for the attending clinician due to the multiple possible aetiologies. Accurate diagnosis is important because treatment varies depending on the aetiology, and some rashes can be life-threatening if not treated promptly. Read More

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Proteome based mapping and reverse vaccinology techniques to contrive multi-epitope based subunit vaccine (MEBSV) against Streptococcus pyogenes.

Infect Genet Evol 2022 06 26;100:105259. Epub 2022 Feb 26.

Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Pakistan. Electronic address:

Streptococcus pyogenes is a root cause of human infection like pharyngitis, tonsillitis, scarlet fever, impetigo, and respiratory tract infections. About 11 million individuals in the US suffer from pharyngitis every year. Unfortunately, no vaccine against S. Read More

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Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study.

Mol Autism 2022 02 19;13(1). Epub 2022 Feb 19.

Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet and Child and Adolescent Psychiatry, Stockholm Health Care Services, Region Stockholm, Stockholm County Council, BUP-FOU Centrum, Gävlegatan 22, 113 30, Stockholm, Sweden.

Background: A significant proportion of variation in likelihood of neurodevelopmental conditions (NDCs) has been attributed to nonshared environmental (NSE) factors, although it remains unclear which NSE factors pose specific risks for certain NDCs.

Methods: A monozygotic co-twin design was applied in a sample of 224 twins (mean age = 17.70 years, SD = 6. Read More

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February 2022

DSM25988 as novel bioactive agent to co-aggregate and to exclude it by binding to human cells.

Benef Microbes 2022 Feb 11;13(1):83-94. Epub 2022 Feb 11.

Belano medical AG, Neuendorfstraße 19, 16761 Hennigsdorf, Germany.

, a group A streptococcus, is the major bacterial pathogen responsible for acute bacterial infection of the human oropharynx and the causative agent of scarlet fever. Estimates of the global burden of related diseases revealed 616 million cases of pharyngitis, and at least 517,000 deaths due to severe invasive diseases and sequelae. Here we describe DSM25988 that was identified among hundreds of strains (referring to all organisms that were classified as until 2020) showing ability to prevent adhesion of to Detroit 562 cells, and to exhibit a masking and co-aggregating effect on . Read More

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February 2022

Prevalence of Infectious Diseases Among 6078 Individuals With Down Syndrome in the United States.

J Patient Cent Res Rev 2022 17;9(1):64-69. Epub 2022 Jan 17.

Advocate Aurora Health, Downers Grove, IL.

A recent disease prevalence study of the largest documented Down syndrome (DS) cohort in the United States strongly suggested significant disparity in general infectious disease conditions among individuals with DS versus those without DS. In this follow-up retrospective analysis, we explored these differences in greater detail by calculating prevalence of 52 infectious diseases, across 28 years of data among 6078 individuals with DS and 30,326 age- and sex-matched controls, abstracted from electronic medical records within a large Midwestern health system. We found that the DS cohort had higher prevalence of pneumonias (including aspiration, viral, bacterial, pneumococcal, and unspecified/atypical); otitis externa; and the skin infections impetigo, abscess, and cellulitis. Read More

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January 2022

[Far East scarlet-like fever in a Caucasian man with Yersinia pseudotuberculosis bacteriaemia].

Ugeskr Laeger 2022 01;184(1)

Yersinia pseudotuberculosis is a Gram-negative bacterium causing infection in humans through contaminated water and/or food. The infection commonly occurs as gastroenteritis and fever, abdominal pain due to mesenteric lymphadenitis and diarrhoea. Bacteraemia is rare and is typically seen in immunocompromised patients and occurs with different clinical presentations like Far East scarlet-like fever, splenic abscess, or mimic appendicitis. Read More

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January 2022

Streptococcal superantigens and the return of scarlet fever.

PLoS Pathog 2021 12 30;17(12):e1010097. Epub 2021 Dec 30.

Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.

Streptococcus pyogenes (group A Streptococcus) is a globally disseminated and human-adapted bacterial pathogen that causes a wide range of infections, including scarlet fever. Scarlet fever is a toxin-mediated disease characterized by the formation of an erythematous, sandpaper-like rash that typically occurs in children aged 5 to 15. This infectious disease is caused by toxins called superantigens, a family of highly potent immunomodulators. Read More

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December 2021

Molecular Characteristics of Isolated From Chinese Children With Different Diseases.

Front Microbiol 2021 9;12:722225. Epub 2021 Dec 9.

Microbiology Laboratory, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.

is a bacterial pathogen that causes a wide spectrum of clinical diseases exclusively in humans. The distribution of type, antibiotic resistance and virulence gene expression for varies temporally and geographically, resulting in distinct disease spectra. In this study, we analyzed antibiotic resistance and resistance gene expression patterns among isolates from pediatric patients in China and investigated the relationship between virulence gene expression, type, and disease categories. Read More

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December 2021

Impact of non-pharmaceutical interventions during COVID-19 pandemic on pertussis, scarlet fever and hand-foot-mouth disease in China.

J Infect 2022 Feb 23;84(2):e13-e15. Epub 2021 Dec 23.

Department of Clinical Laboratory Medicine, The First Affifiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China; Department of Pathogen Biology, School of Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China,; Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China. Electronic address:

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February 2022

Clinical management and impact of scarlet fever in the modern era: findings from a cross-sectional study of cases in London, 2018-2019.

BMJ Open 2021 12 24;11(12):e057772. Epub 2021 Dec 24.

Department of Infectious Disease, Imperial College London, London, UK

Objectives: In response to increasing incidence of scarlet fever and wider outbreaks of group A streptococcal infections in London, we aimed to characterise the epidemiology, symptoms, management and consequences of scarlet fever, and to identify factors associated with delayed diagnosis.

Design And Setting: Cross-sectional community-based study of children with scarlet fever notified to London's three Health Protection Teams, 2018-2019.

Participants: From 2575 directly invited notified cases plus invitations via parental networks at 410 schools/nurseries with notified outbreaks of confirmed/probable scarlet fever, we received 477 responses (19% of those directly invited), of which 412 met the case definition. Read More

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December 2021

Public Health Measures During the COVID-19 Pandemic Reduce the Spread of Other Respiratory Infectious Diseases.

Front Public Health 2021 10;9:771638. Epub 2021 Nov 10.

Department of Infectious Diseases, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Public health measures (such as wearing masks, physical distancing, and isolation) have significantly reduced the spread of the coronavirus disease-2019 (COVID-19), but the impact of public health measures on other respiratory infectious diseases is unclear. To assess the correlation between public health measures and the incidence of respiratory infectious diseases in China during the COVID-19 pandemic. We collected the data from the National Health and Construction Commission in China on the number of patients with six respiratory infectious diseases (measles, tuberculosis, pertussis, scarlet fever, influenza, and mumps) from 2017 to 2020 and assessed the correlation between public health measures and the incidence of respiratory infectious diseases. Read More

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December 2021

Normal values of antistreptolysin O for adults ages 30 to 70 in Syria: A cross sectional study.

Ann Med Surg (Lond) 2021 Nov 5;71:103015. Epub 2021 Nov 5.

Department of Laboratory, Aleppo University Hospital, Aleppo, Syria.

Background: Group A Streptococcus is a very common pathogen which infects a large scale of people around the world causing many symptoms such as scarlet fever, sinusitis, and pneumonia. Most strains of group A and many other strains of group C and G Streptococcus bacteria secreted antigen called Streptolysin O. Anti-streptolysin O (ASO) is an antibody produced against streptolysin O that rises after 1 week of infection by streptococcus bacteria, which helps in diagnosing this type of infectious diseases. Read More

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November 2021

Identification of epidemic scarlet fever group A strains in the paediatric population of Houston, TX, USA.

Access Microbiol 2021 26;3(10):000274. Epub 2021 Oct 26.

Division of Infectious Diseases, Department of Pediatrics, McGovern Medical School at the University of Texas Health Sciences Center at Houston, Houston, Texas, USA.

Scarlet fever (SF) has recently been associated with group A streptococcal (GAS) strains possessing multidrug resistance and specific streptococcal exotoxins. We screened a local surveillance collection of GAS strains in Houston, TX, USA for antimicrobial resistance and identified a single isolate matching the antimicrobial resistance pattern previously reported for SF clones. Using whole-genome sequencing and combining genome sequence data derived from national surveillance databases, we identified additional GAS clones similar to those associated with prior SF outbreaks, emphasizing the need for continued surveillance for epidemic emergence in the USA. Read More

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October 2021

Scarlet fever in an adult patient: A challenging diagnosis in an airway emergency.

SAGE Open Med Case Rep 2021 7;9:2050313X211049908. Epub 2021 Oct 7.

Hospital Center Tondela-Viseu, Anesthesiology Service, Viseu, Portugal.

Scarlet fever is essentially a childhood disease, although it may occur in all ages. Early diagnosis and treatment are essential in preventing the spread of infection and progression to life-threatening complications. The case presented describes the clinical difficulty in the diagnosis of scarlet fever in an adult patient with acute involvement of the airway (oedematous laryngitis) and the need for emergent orotracheal intubation and eventually tracheotomy. Read More

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October 2021

The association between ambient air pollution and scarlet fever in Qingdao, China, 2014-2018: a quantitative analysis.

BMC Infect Dis 2021 Sep 21;21(1):987. Epub 2021 Sep 21.

Qingdao Women and Children's Hospital, Qingdao University, No.6 Tongfu Road, Qingdao City, 266000, Shandong Province, People's Republic of China.

Background: We conducted a distributed lag non-linear time series analysis to quantify the association between air pollution and scarlet fever in Qingdao city during 2014-2018.

Methods: A distributed lag non-linear model (DLNM) combined with a generalized additive mixed model (GAMM) was applied to quantify the distributed lag effects of air pollutions on scarlet fever, with daily incidence of scarlet fever as the dependent variable and air pollutions as the independent variable adjusted for potential confounders.

Results: A total of 6316 cases of scarlet fever were notified, and there were 376 days occurring air pollution during the study period. Read More

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September 2021

Analysis of spatial-temporal distribution of notifiable respiratory infectious diseases in Shandong Province, China during 2005-2014.

BMC Public Health 2021 08 30;21(1):1597. Epub 2021 Aug 30.

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, No.619 Changcheng Road, Taian, 271016, Shandong Province, China.

Background: Little comprehensive information on overall epidemic trend of notifiable respiratory infectious diseases is available in Shandong Province, China. This study aimed to determine the spatiotemporal distribution and epidemic characteristics of notifiable respiratory infectious diseases.

Methods: Time series was firstly performed to describe the temporal distribution feature of notifiable respiratory infectious diseases during 2005-2014 in Shandong Province. Read More

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[Risk factors for multiple sclerosis in the Kabardino-Balkar Republic].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(7. Vyp. 2):65-69

Berbekov Kabardino-Balkar State University, Nalchik, Russia.

The Purpose Of The Study: To study the features of the representation of risk factors for the development of multiple sclerosis (MS) in the Kabardino-Balkar Republic (KBR).

Material And Methods: The results of the examination and follow - up of patients with MS for 5 years (2012-2015) living in two regions of the CBD-Nalchik and the Prokhladnensky district-were analyzed. For the diagnosis of MS, the McDonald criteria (2010) were used, and the EDSS scale was used to assess the severity of invalidization. Read More

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Infectious Respiratory Diseases Decreased during the COVID-19 Pandemic in South Korea.

Int J Environ Res Public Health 2021 06 3;18(11). Epub 2021 Jun 3.

Department of Integrative Bioscience & Biotechnology, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul 05006, Korea.

Infectious respiratory diseases are highly contagious and very common, and thus can be considered as one of the leading causes of morbidity and mortality worldwide. We followed up the incidence rates (IRs) of eight infectious respiratory diseases, including chickenpox, measles, pertussis, mumps, invasive pneumococcal disease, scarlet fever, rubella, and meningococcal disease, after COVID-19 mitigation measures were implemented in South Korea, and then compared those with the IRs in the corresponding periods in the previous 3 years. Overall, the IRs of these diseases before and after age- or sex-standardization significantly decreased in the intervention period compared with the pre-intervention periods ( < 0. Read More

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