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    2755 results match your criteria Scarlet Fever

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    Unusual case of suspected recurrent scarlet fever in a UK serviceman.
    J R Army Med Corps 2018 Apr 13. Epub 2018 Apr 13.
    Academic Department of Military General Practice and Primary Care, Royal Centre for Defence Medicine, Birmingham, UK.
    The UK prevalence of scarlet fever, a Group A streptococcal infection, is increasing. We present an unusual case of suspected recurrent scarlet fever in a member of the UK Armed Forces. Treatments, occupational implication and public health measures to mitigate the risk of disease spread. Read More

    Investigation of Scarlet Fever Outbreak in a Kindergarten.
    Infect Chemother 2018 Mar;50(1):38-42
    Department of Epidemiology and Medical Informatics, Graduate School of Public Health, Korea University, Seoul, Korea.
    Background: Scarlet fever is caused by a group A streptococcal (GAS) infection. On April 3, 2017, an outbreak among children in a kindergarten was reported to the local health department. An epidemiologic investigation was conducted to identify the possible transmission route of this outbreak and to recommend appropriate control measures. Read More

    Identification and Characterization of Fluoroquinolone Non-susceptible Clones Harboring Tetracycline and Macrolide Resistance in Shanghai, China.
    Front Microbiol 2018 23;9:542. Epub 2018 Mar 23.
    Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
    , also known as group A (GAS), is one of the top 10 infectious causes of death worldwide. Macrolide and tetracycline resistant GAS has emerged as a major health concern in China coinciding with an ongoing scarlet fever epidemic. Furthermore, increasing rates of fluoroquinolone (FQ) non-susceptibility within GAS from geographical regions outside of China has also been reported. Read More

    [Study on early warning threshold values for 7 common communicable diseases in Gansu province, 2016].
    Zhonghua Liu Xing Bing Xue Za Zhi 2018 Mar;39(3):352-356
    Institute for Communicable Disease Control and Prevention, Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, China.
    To optimize the warning threshold values of common communicable diseases in Gansu province, and improve the early warning effect. An early warning model was set up for influenza, scarlet fever, other infectious diarrheal diseases, dysentery, typhoid and paratyphoid, viral hepatitis type E and hand foot and mouth disease (HFMD) respectively in Gansu by using the moving percentile method and cumulative sum method. By calculating the sensitivity, specificity, predictive value of positive test, predictive value of negative test, Youden' index and receiver-operating characteristic curve, the optimum early warning threshold values for communicable diseases in Gansu were selected. Read More

    Scarlet Fever Epidemic in China Caused by Streptococcus pyogenes Serotype M12: Epidemiologic and Molecular Analysis.
    EBioMedicine 2018 Feb 11;28:128-135. Epub 2018 Jan 11.
    State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address:
    From 2011, Hong Kong and mainland China have witnessed a sharp increase in reported cases, with subsequent reports of epidemic scarlet fever in North Asia and the United Kingdom. Here we examine epidemiological data and investigate the genomic context of the predominantly serotype M12 Streptococcus pyogenes scarlet fever isolates from mainland China. Incident case data was obtained from the Chinese Nationwide Notifiable Infectious Diseases Reporting Information System. Read More

    'Outbreak Gold Standard' selection to provide optimized threshold for infectious diseases early-alert based on China Infectious Disease Automated-alert and Response System.
    J Huazhong Univ Sci Technolog Med Sci 2017 Dec 21;37(6):833-841. Epub 2017 Dec 21.
    Center for Disease Control and Prevention, Atlanta, 30329-4027, USA.
    The China Infectious Disease Automated-alert and Response System (CIDARS) was successfully implemented and became operational nationwide in 2008. The CIDARS plays an important role in and has been integrated into the routine outbreak monitoring efforts of the Center for Disease Control (CDC) at all levels in China. In the CIDARS, thresholds are determined using the "Mean+2SD‟ in the early stage which have limitations. Read More

    Increasing Number of Scarlet Fever Cases, South Korea, 2011-2016.
    Emerg Infect Dis 2018 Jan;24(1):172-173
    The increasing number of reported scarlet fever cases during 2011‒2016 in the National Notifiable Infectious Disease database in South Korea occurred because of increased overall reporting and expanded reporting criteria rather than because of increasing scarlet fever incidence. Further increases are anticipated because of other expansions in reporting requirements. Read More

    Resurgence of scarlet fever in England, 2014-16: a population-based surveillance study.
    Lancet Infect Dis 2018 Feb 27;18(2):180-187. Epub 2017 Nov 27.
    National Infection Service, Public Health England, London, UK; National Institute for Health Research Health Protection Research Unit in Healthcare-Associated Infection & Antimicrobial Resistance, Imperial College, London, UK.
    Background: After decades of decreasing scarlet fever incidence, a dramatic increase was seen in England beginning in 2014. Investigations were launched to assess clinical and epidemiological patterns and identify potential causes.

    Methods: In this population-based surveillance study, we analysed statutory scarlet fever notifications held by Public Health England from 1911 to 2016 in England and Wales to identify periods of sudden escalation of scarlet fever. Read More

    Far East Scarlet-like Fever Masquerading as Adult-onset Kawasaki Disease.
    Intern Med 2018 Feb 1;57(3):437-440. Epub 2017 Nov 1.
    Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.
    A previously healthy 31-year-old man was referred to us with refractory septic shock accompanied by bilateral conjunctival congestion and erythema of his right lower limb. Nine days after admission, he had bilateral desquamation of the fingertips, and his presentation satisfied the criteria for Kawasaki disease. A serological examination was positive for Yersinia pseudotuberculosis, and he was diagnosed with Far East scarlet-like fever (FESLF). Read More

    Scarlet fever: a guide for general practitioners.
    London J Prim Care (Abingdon) 2017 Sep 11;9(5):77-79. Epub 2017 Aug 11.
    Department of Primary Care and Public Health, Imperial College London, London, UK.
    There has been an increase in the incidence of scarlet fever with most cases presenting in General Practice and Emergency Departments. Cases present with a distinctive macro-papular rash, usually in children. This article aims to increase awareness of scarlet fever by highlighting key symptoms and stating potential complications if untreated. Read More

    Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies.
    J Leukoc Biol 2018 Feb 29;103(2):193-213. Epub 2017 Dec 29.
    School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Australia.
    Streptococcus pyogenes, the Group A Streptococcus (GAS), is the most common cause of bacterial pharyngitis in children and adults. Innate and adaptive host immune responses are fundamental for defense against streptococcal pharyngitis and are central to the clinical manifestation of disease. Host immune responses also contribute to the severe poststreptococcal immune diseases that constitute the major disease burden for this organism. Read More

    Complete Genome Sequences of Type Strain GUR, with Antitumor Activity, and Its Derivative Strain GURSA1 with an Inactivated Gene.
    Genome Announc 2017 Sep 21;5(38). Epub 2017 Sep 21.
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    We present here the complete genome sequence of type strain GUR, a throat isolate from a scarlet fever patient, which has been used to treat cancer patients in the former Soviet Union. We also present the complete genome sequence of its derivative strain GURSA1 with an inactivated gene. Read More

    Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.
    Nat Commun 2017 09 19;8(1):599. Epub 2017 Sep 19.
    23andMe, Mountain View, CA, 94041, USA.
    Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P < 5 × 10) associations in genes with key roles in immunity and embryonic development. Read More

    Managing scarlet fever.
    • Authors:
    Drug Ther Bull 2017 Sep;55(9):102
    Scarlet fever, an infection caused by toxin-producing strains of Streptococcus pyogenes, was associated with high levels of morbidity and mortality when epidemics were common in the 18 and 19 centuries throughout Europe and the USA. Although this disease nearly disappeared during the 20 century, several countries, including the UK, have recently experienced a re-emergence of scarlet fever. However, the reason for these new outbreaks remains unclear. Read More

    Spatiotemporal epidemiology of scarlet fever in Jiangsu Province, China, 2005-2015.
    BMC Infect Dis 2017 08 30;17(1):596. Epub 2017 Aug 30.
    Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
    Background: A marked increase in the incidence rate of scarlet fever imposed a considerable burden on the health of children aged 5 to 15 years. The main purpose of this study was to depict the spatiotemporal epidemiological characteristics of scarlet fever in Jiangsu Province, China in order to develop and implement effective scientific prevention and control strategies.

    Methods: Smoothed map was used to demonstrate the spatial distribution of scarlet fever in Jiangsu Province. Read More

    Nasopharyngeal infection by requires superantigen-responsive Vβ-specific T cells.
    Proc Natl Acad Sci U S A 2017 Aug 9. Epub 2017 Aug 9.
    Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada;
    The globally prominent pathogen secretes potent immunomodulatory proteins known as superantigens (SAgs), which engage lateral surfaces of major histocompatibility class II molecules and T-cell receptor (TCR) β-chain variable domains (Vβs). These interactions result in the activation of numerous Vβ-specific T cells, which is the defining activity of a SAg. Although streptococcal SAgs are known virulence factors in scarlet fever and toxic shock syndrome, mechanisms by how SAgs contribute to the life cycle of remain poorly understood. Read More

    Multivariate time series analysis on the dynamic relationship between Class B notifiable diseases and gross domestic product (GDP) in China.
    Sci Rep 2016 12 23;6(1):29. Epub 2016 Dec 23.
    West China School of Public Health, Sichuan University, Chengdu, China.
    The surveillance of infectious diseases is of great importance for disease control and prevention, and more attention should be paid to the Class B notifiable diseases in China. Meanwhile, according to the International Monetary Fund (IMF), the annual growth of Chinese gross domestic product (GDP) would decelerate below 7% after many years of soaring. Under such circumstances, this study aimed to answer what will happen to the incidence rates of infectious diseases in China if Chinese GDP growth remained below 7% in the next five years. Read More

    An 5 Group A Streptococcal Outbreak Among Workers in a Factory Manufacturing Telephone Accessories.
    Front Microbiol 2017 21;8:1156. Epub 2017 Jun 21.
    Shanghai Municipal Center for Disease Control and PreventionShanghai, China.
    Ranked among the top10 infectious causes of death worldwide, group A (GAS) causes small- and large-scale outbreaks, depending on the trigger as transmission of a GAS strain or expansion of predominant clones. In China, GAS infections other than scarlet fever are not notifiable. In Shanghai, an epidemiological investigation was initiated after two successive severe pneumonia cases with one death in a digital factory, from where outbreaks are less widely reported. Read More

    How to select a proper early warning threshold to detect infectious disease outbreaks based on the China infectious disease automated alert and response system (CIDARS).
    BMC Public Health 2017 06 12;17(1):570. Epub 2017 Jun 12.
    School of Public Health, Fudan University, NO. 130 Dong-An Road, Shanghai, 200032, China.
    Background: China Centre for Diseases Control and Prevention (CDC) developed the China Infectious Disease Automated Alert and Response System (CIDARS) in 2005. The CIDARS was used to strengthen infectious disease surveillance and aid in the early warning of outbreak. The CIDARS has been integrated into the routine outbreak monitoring efforts of the CDC at all levels in China. Read More

    [A multicenter randomized controlled study of in the prevention of antibiotic-associated diarrhea in infants and young children].
    Zhonghua Er Ke Za Zhi 2017 May;55(5):349-354
    West China Second University Hospital, Sichuan University, Chengdu 610041, China.
    To evaluate the efficacy and safety of in the prevention of antibiotic-associated diarrhea (AAD) in infants and young children. From November 2012 to September 2013, ten research units of large teaching hospitals or children's hospitals participated in this multicenter randomized controlled clinical trial. Hospitalized young children aged between 1 month and 3 years (nongastrointestinal infection and antibiotic therapy required)were involved in our study. Read More

    [Brief history of the First Hospital of Harbin City (1913-2013)].
    Zhonghua Yi Shi Za Zhi 2017 Mar;47(2):87-90
    Department of Medical History, Harbin Medical University, Harbin, 150086, China.
    In 1913, after the Russian Prostitutes Sanatorium of Harbin Eastern Railway was received by the board of directors, they established the "Harbin City Board Hospital" and funded its expansion. In March 1926, the provisional Committee of the Harbin autonomous renamed the "City Board of First Hospital" to "The Public Hospital" . In November 1926, "The Public Hospital" was renamed as "Harbin Special Municipal Hospital" by the Harbin City Council and further funds were invested in its construction. Read More

    [Characteristics on the onset features of scarlet fever in Beijing, 2006-2015].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Apr;38(4):514-517
    Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Diseases Prevention and Control, Beijing 100013, China; Beijing Preventive Medicine Research Center, Beijing 100013, China.
    This study aimed to explore the incidence trends and onset features of scarlet fever during the years of epidemic, from 2006 to 2015, in Beijing. Spatial, temporal and population distributions, prognosis of the reported cases and surveillance data on scarlet fever and other streptococcal infections (including the patients of streptococcal infection, tonsillitis and isthmitis) were analyzed by the descriptive epidemiological methods. A total of 27 987 scarlet fever cases were reported from 2006 to 2015, with the incidence rates as 7. Read More

    [An rare complication of scarlet fever : invasive group A streptococcal infection with streptococcal toxic shock syndrome].
    Rev Med Liege 2017 Mar;72(3):132-137
    Service de Pédiatrie, CHU de Liège, Site NDB, Liège, Belgique.
    Invasive Group A Streptococcus infections and streptococcal toxic shock syndrome are rare complications of common diseases in children such as scarlet fever or impetigo. These invasive diseases are particulary challenging because of their rapid progression and the lack of predisposing factors in most cases. Prompt diagnosis and treatment are mandatory to reduce the mortality associated with these severe diseases. Read More

    Immunization with a streptococcal multiple-epitope recombinant protein protects mice against invasive group A streptococcal infection.
    PLoS One 2017 29;12(3):e0174464. Epub 2017 Mar 29.
    Department of Biological Science and Technology, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
    Streptococcus pyogenes (group A Streptococcus; GAS) causes clinical diseases, including pharyngitis, scarlet fever, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. A number of group A streptococcus vaccine candidates have been developed, but only one 26-valent recombinant M protein vaccine has entered clinical trials. Differing from the design of a 26-valent recombinant M protein vaccine, we provide here a vaccination using the polyvalence epitope recombinant FSBM protein (rFSBM), which contains four different epitopes, including the fibronectin-binding repeats domain of streptococcal fibronectin binding protein Sfb1, the C-terminal immunogenic segment of streptolysin S, the C3-binding motif of streptococcal pyrogenic exotoxin B, and the C-terminal conserved segment of M protein. Read More

    Incidence and Characteristics of Scarlet Fever, South Korea, 2008-2015.
    Emerg Infect Dis 2017 04;23(4):658-661
    The incidence rate for scarlet fever in South Korea is rising. During 2008-2015, we collected group A Streptococcus isolates and performed emm and exotoxin genotyping and disk-diffusion antimicrobial tests. Scarlet fever in South Korea was most closely associated with emm types emm4, emm28, emm1, and emm3. Read More

    Evaluation of the Potency, Neutralizing Antibody Response, and Stability of a Recombinant Fusion Protein Vaccine for Streptococcus pyogenes.
    AAPS J 2017 May 10;19(3):875-881. Epub 2017 Mar 10.
    VaxForm, LLC, Bethlehem, Pennsylvania, USA.
    Streptococcus pyogenes or group A streptococcus (GAS) is a Gram-positive bacterium that can cause a wide range of diseases, including pharyngitis, impetigo, scarlet fever, necrotizing fasciitis, rheumatic fever, and streptococcal toxic shock syndrome. Despite the increasing burden on global health caused by GAS, there is currently no licensed vaccine available. In this study, we evaluated immunogenicity, induction of neutralizing antibodies, and stability of a new recombinant fusion protein vaccine that targets infections from GAS. Read More

    Genome analysis following a national increase in Scarlet Fever in England 2014.
    BMC Genomics 2017 03 10;18(1):224. Epub 2017 Mar 10.
    National Infection Service, Public Health England, 61 Colindale Avenue, London, NW9 5HT, UK.
    Background: During a substantial elevation in scarlet fever (SF) notifications in 2014 a national genomic study was undertaken of Streptococcus pyogenes (Group A Streptococci, GAS) isolates from patients with SF with comparison to isolates from patients with invasive disease (iGAS) to test the hypotheses that the increase in SF was due to either the introduction of one or more new/emerging strains in the population in England or the transmission of a known genetic element through the population of GAS by horizontal gene transfer (HGT) resulting in infections with an increased likelihood of causing SF. Isolates were collected to provide geographical representation, for approximately 5% SF isolates from each region from 1 April 2014 to 18 June 2014. Contemporaneous iGAS isolates for which genomic data were available were included for comparison. Read More

    Effects of meteorological factors on incidence of scarlet fever during different periods in different districts of China.
    Sci Total Environ 2017 Mar 7;581-582:19-24. Epub 2017 Jan 7.
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, China. Electronic address:
    Objective: To reveal the difference of meteorological effect on scarlet fever in Beijing and Hong Kong, China, during different periods among 2004-2014.

    Methods: The data of monthly incidence of scarlet fever and meteorological variables from 2004 to 2014 in Beijing and Hong Kong were collected from Chinese science data center of public health, meteorological data website and Hong Kong observatory website. The whole study period was separated into two periods by the outbreak year 2011 (Jan 2004-Dec 2010 and Jan 2011-Dec 2014). Read More

    Mechanisms of Yersinia YopO kinase substrate specificity.
    Sci Rep 2017 Jan 4;7:39998. Epub 2017 Jan 4.
    Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore.
    Yersinia bacteria cause a range of human diseases, including yersiniosis, Far East scarlet-like fever and the plague. Yersiniae modulate and evade host immune defences through injection of Yersinia outer proteins (Yops) into phagocytic cells. One of the Yops, YopO (also known as YpkA) obstructs phagocytosis through disrupting actin filament regulation processes - inhibiting polymerization-promoting signaling through sequestration of Rac/Rho family GTPases and by using monomeric actin as bait to recruit and phosphorylate host actin-regulating proteins. Read More

    Multivariate time series analysis on the dynamic relationship between Class B notifiable diseases and gross domestic product (GDP) in China.
    Sci Rep 2016 12 23;6:29. Epub 2016 Dec 23.
    West China School of Public Health, Sichuan University, Chengdu, China.
    The surveillance of infectious diseases is of great importance for disease control and prevention, and more attention should be paid to the Class B notifiable diseases in China. Meanwhile, according to the International Monetary Fund (IMF), the annual growth of Chinese gross domestic product (GDP) would decelerate below 7% after many years of soaring. Under such circumstances, this study aimed to answer what will happen to the incidence rates of infectious diseases in China if Chinese GDP growth remained below 7% in the next five years. Read More

    RCGP Research and Surveillance Centre Annual Report 2014-2015: disparities in presentations to primary care.
    Br J Gen Pract 2017 Jan 19;67(654):e29-e40. Epub 2016 Dec 19.
    Clinical Innovation and Research Centre, RCGP, London.
    Background: The Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) comprises over 100 general practices in England, with a population of around 1 million, providing a public health surveillance system for England and data for research.

    Aim: To demonstrate the scope of data with the RCGP Annual Report 2014-2015 (May 2014 to April 2015) by describing disparities in the presentation of six common conditions included in the report.

    Design And Setting: This is a report of respiratory and communicable disease incidence from a primary care sentinel network in England. Read More

    [Renal decapsulation for the treatment of anuria : A "forgotten" treatment from the early 20th century].
    Urologe A 2017 Jan;56(1):54-59
    Klinik und Poliklinik für Urologie, Universitätsmedizin Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Deutschland.
    In the early 20th century, Harrison first performed renal decapsulation in anuric children with scarlet fever and observed improvement in renal function postoperatively. The pathophysiological explanation was seen in intraparenchymal renal pressure due to edema which was improved by surgical decapsulation. The technique of decapsulation was simple excision after incision and blunt dissection of the renal parenchyma. Read More

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