Search Our Scientific Publications & Authors

Int J Colorectal Dis 2018 Dec 13. Epub 2018 Dec 13.

Division of General Surgery, IRCCS Policlinico San Donato, Department of Biomedical Sciences of Health, University of Milan Medical School, San Donato Milanese, Milan, Italy.

Background: The importance of the defunctioning stoma on minimizing anastomotic leak in colorectal surgery is well established. However, a defunctioning stoma can substantially impact on quality of life (QoL). Circumferential purse-string approximation (PSA) and linear skin closure (LSC) are the most commonly performed surgical technique for reversal of stoma. Read More

Burns 2018 Dec 10. Epub 2018 Dec 10.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. Electronic address:

Background: Vascularity is an important parameter closely associated with the scar maturation. Reliable and accurate measurement of vascularity helps to monitor the scar change and adopt targeted interventions to prevent excessive scarring and achieve promising outcomes. However, there is no consensus on the assessment tools for the vascularity measurement in scars. Read More

Burns 2018 Dec 10. Epub 2018 Dec 10.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK. Electronic address:

Introduction: For severe burns patient care presents a considerable challenge, necessitating an integrated multi-disciplinary approach that utilises a range of treatments. The period of care post-discharge can be lengthy and complex, and include scar management, occupational and physiotherapies, psychological support, and further surgery. How successfully the patient negotiates this complex care regimen is critical to their long-term recovery and in doing so they would appear to employ approaches recognised as "self-management" in other chronic conditions. Read More

Taiwan J Obstet Gynecol 2018 Dec;57(6):911

Department of Obstetrics and Gynecology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address:

Med Sci Monit 2018 Dec 13;24:9032-9044. Epub 2018 Dec 13.

Institute of Burns, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).

BACKGROUND Hedgehog (Hh) signaling pathway-related genes have important roles in several physiological and disease processes that involve cell proliferation. Long non-coding region RNAs (lncRNAs) have a regulatory role on gene expression. Keloid is characterized by excessive proliferation of scar tissue following trauma. Read More

Hypertension 2019 Jan;73(1):102-111

From the Department of Cardiology and Angiology, Hannover Medical School, Germany (D.F., S.T., D.H.-K., P.G., J.B.).

Myocardial infarction (MI) is a major cause of death worldwide. Here, we identify the macrophage MR (mineralocorticoid receptor) as a crucial pathogenic player in cardiac wound repair after MI. Seven days after left coronary artery ligation, mice with myeloid cell-restricted MR deficiency compared with WT (wild type) controls displayed improved cardiac function and remodeling associated with enhanced infarct neovascularization and scar maturation. Read More

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Cardiac tissue engineering (CTE) remains a great challenge to construct a cell-inductive scaffold which has positive effects on cardiac cell behaviors and cardiac tissue repair. In this study, we for the first time demonstrated that Si ions evidently stimulated the expression of cardiac specific genes and proliferation of neonatal rat cardiomyocytes (NRCMs) at concentration ranges of 0.13 ~ 10. Read More

Rare Tumors 2018 5;10:2036361318809183. Epub 2018 Nov 5.

Section of Histopathology, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Background: Serous cystadenomas of pancreas are rare benign epithelial neoplasms, which predominantly occur in the pancreatic body and tail of elderly females. Majority of these tumors have microcystic appearance. Macrocystic and solid variants have also been described. Read More

Front Neurol 2018 27;9:1014. Epub 2018 Nov 27.

Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

Despite the clinical significance of post-stroke angiogenesis, a detailed phenotypic analysis of pre-stroke vascular remodeling and post-stroke angiogenesis had not yet been done in a model of focal ischemia. In this study, using BrdU-labeling of proliferating cells and immunofluorescence of pre- and post-stroke rats, we found that, (i) BrdU administered before stroke was incorporated preferentially into the nuclei of endothelial cells lining the lumen of existing blood vessels and newly born neurons in the dentate gyrus but not in the subventricular zone or proliferating microglia, (ii) BrdU injection prior to stroke led to the patchy distribution of the newly incorporated endothelial cells into existing blood vessels of the adult rat brain, (iii) BrdU injection prior to stroke specifically labeled neuronal precursors cells in a region of soft tissue beyond the inhibitory scar, which seems to be permissive to regenerative events, (iv) BrdU injection after stroke led to labeling of endothelial cells crossing or detaching from the disintegrating blood vessels and their incorporation into new blood vessels in the stroke region, scar tissue and the region beyond, (v) BrdU injection after stroke led to specific incorporation of BrdU-positive nuclei into the "pinwheel" architecture of the ventricular epithelium, (vi) blood vessels in remote areas relative to the infarct core and in the contralateral non-lesioned cortex, showed co-labeled BrdU/RECA endothelial cells shortly after the BrdU injection, which strongly suggests a bone marrow origin of the endothelial cells. In the damaged cortex, a BrdU/prolyl 4-hydroxylase beta double labeling in the close proximity to collagen IV-labeled basement membrane, suggests that, in addition to bone marrow derived endothelial cells, the disintegrating vascular wall itself could also be a source of proliferating endothelial cells, (vii) By day 28 after stroke, new blood vessels were observed in the perilesional area and the scar tissue region, which is generally considered to be resistant to regenerative events. Read More

Ann Thorac Cardiovasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiovascular Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, China.

Background: Repair of doubly committed subarterial ventricular septal defects (DCVSD) via a minimal mid-partial sternotomy has not been reported. We aimed to evaluate the feasibility and safety of this procedure.

Methods: We retrospectively reviewed all patients with a clinical diagnosis of DCVSD and underwent repair via minimal mid-partial sternotomy at our institution. Read More

J Biosci 2018 Dec;43(5):897-909

Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia,

The outcomes of compressed spinal cord injury (CSCI) necessitate radical treatment. The therapeutic potential of neuroectodermal stem cells (NESCs) in a rat model of CSCI in acute and subacute stages was assessed. White Wistar rat were divided into control, sham-operated, CSCI untreated model, CSCI grafted with NESCs at 1 day after CSCI, and at 7 days after CSCI. Read More

Cureus 2018 Sep 29;10(9):e3385. Epub 2018 Sep 29.

Radiation Oncology, The Ottawa Hospital & University of Ottawa, Ottawa, CAN.

We report the case of a woman who presented with breast cancer metastases to the femur causing pathologic fracture of the femoral neck requiring surgery. She received adjuvant radiotherapy to the femur at that time that did not include the surgical scar tract. Almost four years after her surgery she presented with biopsy proven skin recurrence of breast cancer on the skin overlying her incision from her femoral surgery. Read More

Curr Dermatol Rep 2018 28;7(4):350-358. Epub 2018 Sep 28.

Department of Dermatology, University of California, Davis, 3301 C Street, Ste. 1300, Sacramento, CA 95816 USA.

Purpose Of Review: Chronic wounds are a tremendous burden on the healthcare system and lead to significant patient morbidity and mortality. Normal cutaneous wound healing occurs through an intricate and delicate interplay between the immune system, keratinocytes, and dermal cells. Each cell type contributes signals that drive the normal phases of wound healing: hemostasis, inflammation, proliferation, and remodeling. Read More

J Plast Reconstr Aesthet Surg 2018 Nov 2. Epub 2018 Nov 2.

Glasgow Dental Hospital & School, University of Glasgow, 378 Sauchiehall Street, Glasgow G2 3JZ, UK. Electronic address:

Aim: To evaluate the symmetry of facial expression in surgically managed UCLP patients.

Materials And Methods: The study was conducted on 13 four-year-old children. Facial images were captured at rest and at maximum smile using stereophotogrammetry. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Dec;47(12):926-930

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To investigate the clinicopathologic features, diagnostic and differential diagnostic aspects of pigmented microcystic chromophobe renal cell carcinoma (ChRCC). Five cases of pigmented microcystic ChRCC were collected at Zhejiang Provincial People's Hospital from January 2013 to January 2018. The clinical features, gross and histological appearances, immunohistochemistry and prognosis were analyzed and the relevant literature was reviewed. Read More

Evid Based Complement Alternat Med 2018 14;2018:3032790. Epub 2018 Nov 14.

Surgery Department, Indra Gandhi Memorial Hospital, Kanbaa Aisa Rani Higun, Malé, Maldives.

Background: Snakehead fish ( is a fresh water fish indigenous to many Asia countries and believed to have medical value. Studies showed that it contains all the essential amino acids and fatty acids able to accelerate wound healing and it has antinociceptive effect. However, little human study has been done to assess the effectiveness of in wound healing. Read More

Indian J Surg Oncol 2018 Dec 19;9(4):477-482. Epub 2018 May 19.

Department of Head-Neck and Thoracic Surgical Oncology, Fortis Memorial Research Institute (FMRI), Gurugram, Sector-44, Gurugram, Haryana 122002 India.

The aim of this observational prospective study was to determine the technical feasibility, safety, and adequacy of robotic hemithyroidectomy. From April 2015 to May 2016, 16 patients with solitary thyroid lesion underwent robotic hemithyroidectomy using the Surgical system. Patients were observed and data were recorded on surgical time, blood loss, complications, and functional outcome of the patients. Read More

J Cardiol Cases 2013 May 28;7(5):e149-e152. Epub 2013 Feb 28.

Division of Cardioangiology, Nephrology, and Endocrinology, Department of Internal Medicine, Iwate Medical University.

We present a case of spontaneous healing of saccular type aneurysm with ventricular septal lacerations after blunt chest trauma. A 50-year-old Japanese man was transferred to our hospital diagnosed with ventricular septal lacerations after blunt chest trauma. Electrocardiogram (ECG) at admission showed ST elevations in I, II, III, aVL, aVF, V2-through to V6 were observed. Read More

J Cardiol Cases 2011 Dec 14;4(3):e148-e151. Epub 2011 Sep 14.

University of Chicago Medical Center, 5841 South Maryland Avenue, MC 6080, Chicago, IL 60637, USA.

A 21-year-old African American male presented to the emergency department after an episode of unexplained syncope. He had no significant past medical history. The initial physical examination was within normal limits, and his 12-lead electrocardiogram showed no signs of ischemia or evidence of chamber enlargement. Read More

Adv Healthc Mater 2018 Dec 11:e1801076. Epub 2018 Dec 11.

Department of Biomedical Engineering, Pratt School of Engineering, Duke University, 101 Science Drive, Durham, NC, 27705, USA.

Brain tumors remain a great clinical challenge, in part due to their capacity to invade into eloquent, inoperable regions of the brain. In contrast, inflammation in the central nervous system (CNS) due to injuries activates microglia and astrocytes culminating in an astroglial scar that typically "walls-off" the injury site. Here, the hypothesis is tested that targeting peritumoral cells surrounding tumors to activate them via an inflammatory stimulus that recapitulates the sequelae of a traumatic CNS injury, could generate an environment that would wall-off and contain invasive tumors in the brain. Read More

Methods Mol Biol 2019 ;1905:93-101

School of Life Science and Technology, Shanghai Tech University, Shanghai, China.

Primary hepatocytes are widely used in regenerative medicine, drug metabolism analysis, and in vitro drug screens. To overcome the shortage of liver donors, several strategies, such as differentiation of pluripotent stem cells and transdifferentiation from somatic cells, were developed to generate hepatocytes from alternative sources. Here, we describe in detail lenti-virus-based procedure for direct conversion of human fibroblasts to hepatocytes (hiHep cells) in vitro. Read More

World J Urol 2018 Dec 10. Epub 2018 Dec 10.

Fasa University of Medical Sciences, Fasa, Iran.

Purpose: Local injection of platelet-rich plasma (PRP) is postulated to work by delivering growth factors and cytokines that recruit healer cells and enhance recovery process at the injection site. As new scar formation leads to stricture recurrence after internal urethrotomy, we proposed to improve post-internal urethrotomy stricture recurrence rate by injecting local submucosal PRP at the time of urethrotomy.

Methods: From July 2015 to June 2018, 87 male patients with symptomatic bulbar urethral stricture (diagnosed by retrograde urethrography) randomized into two groups of internal urethrotomy and submucosal normal saline injection (control group, 43 patients), and internal urethrotomy with submucosal autologous platelet-rich plasma injection (PRP injection group, 44 patients). Read More

Plast Reconstr Surg Glob Open 2018 Oct 4;6(10):e1907. Epub 2018 Oct 4.

Service of Plastic, Reconstructive and Aesthetic Surgery, and Maxillo-facial Surgery, Henri Mondor's Hospital, Créteil Cedex.

Introduction: Massive weight loss following bariatric surgery has a major functional and aesthetic impact on patients. Many patients are nonetheless reluctant to undergo plastic surgery in connection with their former obesity because they fear potentially large scars, even though such scars are not visible (ie, they are covered by undergarments).

Purpose: The aim of this study was to evaluate the quality of wound healing in patients receiving Celergen supplementation following abdominoplasty, compared with a control group. Read More

Plast Reconstr Surg Glob Open 2018 Oct 3;6(10):e1877. Epub 2018 Oct 3.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, Boston, Mass.

Background: Patient's pursuing aesthetic surgery often inquire about the success of the procedure. Having objective data for these patients improves preoperative counseling. To assess patient satisfaction after aesthetic chondrolaryngoplasty using specifically developed outcomes assessment instrument and to evaluate the anatomy of the vocalis insertion on the thyroid cartilage and its effect on the extent of surgical resection. Read More

Plast Reconstr Surg 2018 Nov 26. Epub 2018 Nov 26.

Si-Zheng Zhou, Wen-Jin Wang and Shuang-Bai Zhou contributed equally to this work and should be considered co-first authors.

Background: Current rodent models of wound healing and scarring are flawed due to rapid wound contraction and inconspicuous scarring after healing, which is not closely parallel to the physiological process in human. This study was designed to establish a novel model of wound healing and scarring in rats.

Methods: Excisional wounds were generated in rat tail or dorsal skin and assessed in terms of histological changes and wound contraction 2, 10 and 16 days postinjury. Read More

Adv Skin Wound Care 2018 Dec 7. Epub 2018 Dec 7.

In the Department of Plastic Surgery, Maastricht University Medical Center, the Netherlands, Sander Kant, MD, is a researcher; Eric van den Kerckhove, Prof, is a physiotherapist; Carlo Colla, is orthotist/prosthetist; René van der Hulst, Prof Dr, is plastic surgeon; and Andrzej A. Piatkowski de Grzymala, MD, is plastic surgeon.

Objective: Maturation remains the least understood phase of wound healing; estimates of maturation time are broad and inaccurate. A more precise estimation of maturation time could influence scar therapy and give insight to the wound healing cascade. The objective of this study was to assess the mean time between onset and complete maturation of hypertrophic scars. Read More

Ann Plast Surg 2019 Jan;82(1):64-70

From the Department of Hand and Microsurgery, Xiangya Hospital, Central South University, Changsha, China.

Background: The closure of massive skin defects remains challenging, particularly in children. In this report, we describe a technique to achieve primary donor site closure using the kiss deep inferior epigastric perforator (DIEP) flap for the reconstruction of large soft tissue defects located in the extremities of children.

Methods: From May 2011 to May 2016, a retrospective analysis was conducted on 10 pediatric patients with extensive soft tissue defects and reconstruction with double-skin paddle DIEP flap. Read More

Neural Regen Res 2019 Feb;14(2):328-338

Department of Hand Surgery, the Second Hospital of Jilin University, Changchun, Jilin Province, China.

After nerve-root avulsion injury of the brachial plexus, oxidative damage, inflammatory reaction, and glial scar formation can affect nerve regeneration and functional recovery. Melatonin (MT) has been shown to have good anti-inflammatory, antioxidant, and neuroprotective effects. Chondroitin sulfate ABC (ChABC) has been shown to metabolize chondroitin sulfate proteoglycans and can reduce colloidal scar formation. Read More

Neural Regen Res 2019 Feb;14(2):306-312

Department of Hand Surgery, Huashan Hospital, Fudan University; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China.

Exogenous electrical nerve stimulation has been reported to promote nerve regeneration. Our previous study has suggested that endogenous automatic nerve discharge of the phrenic nerve and intercostal nerve has a positive effect on nerve regeneration at 1 month postoperatively, but a negative effect at 2 months postoperatively, which may be caused by scar compression. In this study, we designed four different rat models to avoid the negative effect from scar compression. Read More

Neural Regen Res 2019 Feb;14(2):265-271

Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, China.

Astrocytes, the major component of blood-brain barriers, have presented paradoxical profiles after cerebral ischemia and reperfusion in vivo and in vitro. Our previous study showed that sevoflurane preconditioning improved the integrity of blood-brain barriers after ischemia and reperfusion injury in rats. This led us to investigate the effects of sevoflurane preconditioning on the astrocytic dynamics in ischemia and reperfusion rats, in order to explore astrocytic cell-based mechanisms of sevoflurane preconditioning. Read More

Proc Natl Acad Sci U S A 2018 Dec 7. Epub 2018 Dec 7.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, 3584 CT Utrecht, The Netherlands;

The significance of cardiac stem cell (CSC) populations for cardiac regeneration remains disputed. Here, we apply the most direct definition of stem cell function (the ability to replace lost tissue through cell division) to interrogate the existence of CSCs. By single-cell mRNA sequencing and genetic lineage tracing using two Ki67 knockin mouse models, we map all proliferating cells and their progeny in homoeostatic and regenerating murine hearts. Read More

Psychiatry Res 2018 Nov 20;271:343-350. Epub 2018 Nov 20.

Research Group Neurocognition, Department of General Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Voßstraße 4, 69115, Heidelberg, Baden-Württemberg, Germany.

Cognitive impairment in Major Depressive Disorder (MDD) has been postulated to persist into remission. However, inconsistent definitions of clinical remission, patterns and influencing factors, isolated cognitive tasks, and the lack of appropriately matched controls (HCs) present significant limitations of previous studies. Furthermore, studies investigating cognition in partially remitted patients are particularly scarce. Read More

J Allergy Clin Immunol Pract 2018 Dec 6. Epub 2018 Dec 6.

Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, Korea. Electronic address:

Background: Although HLA-B*58:01 is a well-known risk factor for the development of allopurinol-induced severe cutaneous adverse reactions (SCARs), most of the HLA-B*58:01 carriers do not suffer from SCARs despite a long-term use of allopurinol. This suggests that there are other risk factors that determine the fate of HLA-B*58:01 carriers.

Objective: The aim of this study was to investigate the additional genetic factors that increases the risk of allopurinol-induced SCARs in HLA-B*58:01 carriers. Read More

Mol Ther 2018 Nov 1. Epub 2018 Nov 1.

Institut für Herz- und Kreislaufphysiologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany. Electronic address:

Insulin-like growth factor 1 (IGF1) is an anabolic hormone that controls the growth and metabolism of many cell types. However, IGF1 also mediates cardio-protective effects after acute myocardial infarction (AMI), but the underlying mechanisms and cellular targets are not fully understood. Here we demonstrate that short-term IGF1 treatment for 3 days after AMI improved cardiac function after 1 and 4 weeks. Read More

J Plast Reconstr Aesthet Surg 2018 Nov 9. Epub 2018 Nov 9.

Department of Plastic, Reconstructive and Aesthetic Surgery, Lausanne University Hospital, Lausanne, Switzerland.

Background: Mastopexy is one of the most performed cosmetic surgery procedures in the U.S. Numerous studies on mastopexy techniques have been published in the past decades, including case reports, retrospective reviews, and prospective studies. Read More

Int J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Background: CD4 T cells are key players in regulating the inflammatory processes and physiological repair mechanisms engaged after acute myocardial infarction (AMI). Although signaling through the CD27-CD70 co-stimulatory pathway are known to be important in CD4 T cell activation and proliferation in certain contexts, the role of the CD27-CD70 pathway in AMI remains unclear.

Methods And Results: A total of 43 control subjects, 42 unstable angina patients, and 90 AMI patients were enrolled in the present study. Read More

J Craniomaxillofac Surg 2018 Nov 12. Epub 2018 Nov 12.

Department of Pediatric Surgery (Head: Professor Ewa Sawicka), Institute of Mother and Child Warsaw, Poland.

Introduction: There is no consensus regarding the optimal timing for secondary alveolar bone grafting for clefts defects. We aimed to investigate the potential correlation between the age of patients during surgery, donor site symptoms, surgical time and hospitalization following this procedure.

Material And Methods: The outcome of 195 consecutive alveolar bone grafting procedures among different age groups (mean: 7. Read More

J Obstet Gynaecol Can 2018 Dec;40(12):1551-1552

Department of Obstetrics and Gynecology, McGill University, Montréal, QC.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurological Surgery, Policlinico "G. Rodolico" University Hospital, Via Santa Sofia 86, 95123 - Catania, Italy.

Background: Arachnoiditis ossificans (AO) is a rare condition often associated with previous spine surgery. Here we describe a unique case of a patient affected by ankylosing spondylitis (AS), presenting with progressive neurological deterioration due to AO. We also review the literature on evaluation and management of patients suffering from AO. Read More

Expert Opin Biol Ther 2018 Dec 6. Epub 2018 Dec 6.

e Chair of Urology, Department of Regenerative Medicine, Collegium Medicum , Nicolaus Copernicus University , Bydgoszcz , Poland ;

Introduction: In reconstructive urology, autologous tissues such as intestinal segments, skin, and oral mucosa are used. Due to their limitations, reconstructive urologists are waiting for a novel material, which would be suitable for urinary tract wall replacement. Human amniotic membrane (AM) is a naturally derived biomaterial with a capacity to support reepithelization and inhibit scar formation. Read More

Ir Med J 2018 06 7;111(6):774. Epub 2018 Jun 7.

Department of Gynaecology, the Adelaide and Meath National Children's Hospital, Dublin, Republic of Ireland

Caesarean scar ectopic pregnancy (CSEP) is one of the rarest forms of ectopic pregnancies. With rising caesarean delivery (CD) rates worldwide, there is an increase in the incidence of CSEP. Patients usually present with painless vaginal bleeding and often misdiagnosed as spontaneous miscarriage. Read More

Musculoskelet Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, India.

Introduction: Open reduction and plate fixation is known to reduce chances of malunion and symptomatic nonunion in displaced middle-third clavicle fractures. However, this treatment modality is also associated with several complications, such as hardware irritation, numbness around the surgical scar, infection, nonunion and implant failure. The minimally invasive plate osteosynthesis (MIPO) technique may reduce these complications. Read More

Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics, University of Leipzig, Liebigstrasse 20a, 04103, Leipzig, Germany.

Purpose: Uterine rupture during labor is a rare but life-threatening complication after previous cesarean section (CS). Prenatal risk is assessed using ultrasound thickness measurement of the lower uterine segment (LUS). Due to inhomogeneous study results, however, clinical obstetrics still lacks for standard protocols and reliable reference values. Read More

Burns Trauma 2018 27;6:33. Epub 2018 Nov 27.

Pegg Leditschke Children's Burns Centre, Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland Australia.

Background: This is a parallel three-arm prospective randomised controlled trial (RCT) comparing Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts (STSG). All three were in current use within the Pegg Leditschke Children's Burn centre (PLCBC), the largest paediatric burns centre in Queensland, Australia. Our objective was to find the best performing dressing, following on from previous trials designed to rationalise dressings for the burn wound itself. Read More

J Clin Aesthet Dermatol 2018 Oct 1;11(10):36-39. Epub 2018 Oct 1.

Drs. Niazi, Hooshyar, Doroodgar, and Niazi are with the Department of Plastic and Reconstructive Surgery at Modarres Hospital School of Medicine at Shahid Beheshti University of Medical Sciences in Tehran, Iran.

Keloid and hypertrophic scars (HTS) are formed by excessive collagen formation. Angiotensin II, through the AT receptor, plays an important role in extracellular matrix production. However, less is known about angiotensin II and AT receptor concentrations in HTS and keloid tissues. Read More

J Clin Aesthet Dermatol 2018 Oct 1;11(10):31-35. Epub 2018 Oct 1.

Drs. Owji, Khademi, and Khalili are with the Poostchi Ophthalmology Research Center at the Shiraz University of Medical Sciences in Shiraz, Iran.

Topical onion extract gel is commonly used in commercial anti-scar medications. The purpose of this study was to evaluate the effectiveness of topical onion extract gel on the appearance of blepharoplasty scars and to compare the results of its use to those of petroleum jelly. The participants enrolled in this prospective, double-blind study were randomly treated with either topical onion extract gel or petroleum jelly. Read More

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Center for Wound Healing and Tissue Regeneration, College of Dentistry, University of Illinois at Chicago, 801 S. Paulina Street, Chicago, IL 60612, USA.

Bicellular tight junctions (TJs) are intercellular junctions comprised of a variety of transmembrane proteins including occludin, claudins, and junctional adhesion molecules (JAMs) as well as intracellular scaffold proteins such as zonula occludens (ZOs). TJs are functional, intercellular structures that form a barrier between adjacent cells, which constantly seals and unseals to control the paracellular passage of molecules. They are primarily present in the epithelial and endothelial cells of all tissues and organs. Read More

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

We have prepared and tested in vivo a novel nanoengineered hybrid electroconductive cardiac patch for treating the infarcted myocardium. Of the prepared and tested patches, only those containing spherical nanogold were able to increase connexin-43 expression in neonatal rat cardiomyocytes cultured under electrical stimulation. In vivo data indicated that only nanogold containing patches were able to recover cardiac function. Read More

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Harvard Integrated Plastic Surgery Program, Boston, MA.

Complete avulsion of the nose is a devastating injury that may result in permanent disfigurement. Microvascular reattachment is technically difficult due to small size of the injured vessels, associated avulsion or crush injury, and relative inability to achieve venous anastomosis. This report describes a successful case of microsurgical replantation of the distal third of the nose in a 47-year-old patient after a dog bite injury with the use of a superficial temporal vein graft for arterial repair and leeching for venous outflow. Read More