8,378 results match your criteria Scandinavian journal of clinical and laboratory investigation[Journal]


Shrunken pore syndrome, preeclampsia, and markers of NO metabolism in pregnant women during the first trimester.

Scand J Clin Lab Invest 2019 Feb 20:1-8. Epub 2019 Feb 20.

i Kantonsspital Graubünden , Zentrallabor , Chur , Switzerland.

Shrunken pore syndrome (SPS) is a condition that manifests itself as the decreased renal clearance of low-molecular-weight proteins but normal clearance of creatinine. Pregnant women with evidence of SPS during the first trimester have an increased risk of developing preeclampsia (PE). The nitric oxide (NO) metabolism markers arginine and ADMA, especially their ratio (Arg/ADMA), are recognized markers of endothelial dysfunction. Read More

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http://dx.doi.org/10.1080/00365513.2019.1568150DOI Listing
February 2019

Relation between invasive hemodynamics and measured glomerular filtration rate by Cr-EDTA clearance in advanced heart failure.

Scand J Clin Lab Invest 2019 Feb 20:1-8. Epub 2019 Feb 20.

a Department of Cardiology , Rigshopsitalet , Copenhagen , Denmark.

The interaction between hemodynamics and kidney function in heart failure (HF) is incompletely understood. We investigated the association between invasive hemodynamic parameters and measured glomerular filtration rate (mGFR) by plasma clearance of 51-chromium-labeled ethylenediamine tetra-acetic acid (Cr-EDTA) in patients with advanced HF and tested the hypothesis that patients with reduced mGFR have lower cardiac index (CI) and mean arterial pressure (MAP) as well as higher central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP). We retrospectively studied 242 patients (mean age 50 ± 13 years) referred for evaluation for heart transplantation or implantation of a left ventricular assist device with a left ventricular ejection fraction < 45% on optimal medical therapy, who underwent right heart catheterization (RHC) and measurement of Cr-EDTA clearance. Read More

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http://dx.doi.org/10.1080/00365513.2019.1576221DOI Listing
February 2019

Long-term prognostic impact of hyperuricemia in community.

Scand J Clin Lab Invest 2019 Feb 19:1-6. Epub 2019 Feb 19.

a Department of Internal Medicine , Päijät-Häme Central Hospital , Lahti , Finland.

The debate whether an elevated level of serum uric acid (SUA) is an independent marker of cardiovascular risk is still going on. We examined morbidity and mortality related to SUA and hyperuricemia in a well-characterized population with very long follow-up. Study included 4696 participants (aged 30-59 years at baseline) of the coronary heart disease (CHD) Study of the Finnish Mobile Clinic Health Examination Survey. Read More

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http://dx.doi.org/10.1080/00365513.2019.1576098DOI Listing
February 2019

The individual systematic difference between CoaguChek and STA-SPA.

Scand J Clin Lab Invest 2019 Feb 19:1-5. Epub 2019 Feb 19.

a Department of Clinical Chemistry , Trondheim University Hospital , Trondheim , Norway.

Using CoaguChek to measure PT-INR and comparing the results with those from the hospital laboratory, some patients get consistent results while others do not. The extent of this problem is unknown. Our study aimed to quantify the between-subject variation of the systematic PT-INR difference between CoaguChek and a hospital laboratory method. Read More

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http://dx.doi.org/10.1080/00365513.2019.1576097DOI Listing
February 2019

Validation of plasma thyroxine and triiodothyronine methods on the ADVIA Centaur XP.

Scand J Clin Lab Invest 2019 Feb 19:1-7. Epub 2019 Feb 19.

a Department of Clinical Biochemistry, North Zealand Hospital , University of Copenhagen , Hilleroed , Denmark.

Standardization programs for thyroid hormones have revealed bias between immunochemical methods and the reference method ED-ID-LC/MS. Lack of standardization between methods, suboptimal reference intervals and replacement of serum with plasma may compromise the capability of the immunochemical thyroid methods to diagnose thyroid disease. To accommodate the demand for faster turn-around times for laboratory replies, we replaced serum with plasma on some serum CE marked thyroid methods. Read More

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http://dx.doi.org/10.1080/00365513.2019.1571624DOI Listing
February 2019

Long-term follow-up of biomarkers of vascular calcification after switch from traditional hemodialysis to online hemodiafiltration.

Scand J Clin Lab Invest 2019 Feb 18:1-8. Epub 2019 Feb 18.

d Department of Clinical Chemistry and Department of Clinical and Experimental Medicine , Linköping University , Linköping , Sweden.

Rapid progression of vascular calcification (VC) in hemodialysis (HD) patients is caused by several factors including inflammation and an imbalance between active inducers and inhibitors of VC. Growing evidence shows that online hemodiafiltration (ol-HDF), a combination of diffusive and convective solute transport, has positive effects on the uremic environment that affects patients on dialysis. However, we recently reported that serum 25-hydroxyvitamin D (25(OH)D) decreased after a switch from HD to ol-HDF. Read More

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http://dx.doi.org/10.1080/00365513.2019.1576218DOI Listing
February 2019

Influence of hemolysis on clinical chemistry parameters determined with Beckman Coulter tests - detection of clinically significant interference.

Scand J Clin Lab Invest 2019 Feb 15:1-6. Epub 2019 Feb 15.

a Department of Laboratory Diagnostics , Dubrovnik General Hospital , Dubrovnik , Croatia.

The aim of this study was to examine the influence of hemolysis on 25 clinical chemistry parameters and to compare the resulting bias with clinically significant differences and the manufacturer's specifications. Using freeze-thawing of the treated blood aliquot of each subject (N = 17), four hemolysis levels were prepared with hemolysis index (HI) and hemoglobin concentration as follows: (+)=0.5-0. Read More

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http://dx.doi.org/10.1080/00365513.2019.1576099DOI Listing
February 2019
1 Read

Body fat percentage is more strongly associated with biomarkers of low-grade inflammation than traditional cardiometabolic risk factors in healthy young adults - the Lifestyle, Biomarkers, and Atherosclerosis study.

Scand J Clin Lab Invest 2019 Feb 15:1-6. Epub 2019 Feb 15.

d Faculty of Medicine and Health, School of Health , Örebro University , Örebro , Sweden.

The primary aim was to appraise the relationship between body fat percentage and the inflammatory markers C-reactive protein (CRP) and orosomucoid in a population of young, non-smoking, healthy, Swedish adults, without any chronic diseases. A secondary aim was to compare whether these associations differed between the women using estrogen contraceptives and those who did not. We assessed the association in linear regression models between body fat percentage based on a bio-impedance measurement and plasma concentrations of CRP and orosomucoid in men and women aged 18-26 years, n = 834. Read More

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http://dx.doi.org/10.1080/00365513.2019.1576219DOI Listing
February 2019
1 Read

The mortality increase in cardiac surgery patients associated with shrunken pore syndrome correlates with the eGFR/eGFR-ratio.

Scand J Clin Lab Invest 2019 Feb 15:1-7. Epub 2019 Feb 15.

a Department of Cardiothoracic Surgery , Skåne University Hospital , Lund , Sweden.

Shrunken pore syndrome (SPS) is a condition in which estimated glomerular filtration rate (eGFR) based upon cystatin C is lower than eGFR based upon creatinine. It has been associated with increased mortality even in the presence of normal GFR in both a cardiac surgical population and a general population. No systematic studies of the variation in eGFR/eGFR-ratio used for SPS diagnosis have been published. Read More

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http://dx.doi.org/10.1080/00365513.2019.1576101DOI Listing
February 2019

Telomerase stability and evaluation of real-time telomeric repeat amplification protocol.

Scand J Clin Lab Invest 2019 Feb 15:1-6. Epub 2019 Feb 15.

b Faculty of Pharmacy, Department of Clinical Biochemistry , University of Ljubljana , Ljubljana , Slovenia.

Telomerase is RNA directed polymerase which acts as reverse transcriptase based on its own RNA component. It is considered to be involved in the pathology of many diseases and is recognized as a potential biomarker. The aims were to determine the sample storage conditions and the time frame for samples analysis, then to prove reliability of enzyme activity measurement with real-time telomeric repeat amplification protocol (TRAP) and to evaluate the suitable standard samples for telomerase activity measurements. Read More

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http://dx.doi.org/10.1080/00365513.2019.1576220DOI Listing
February 2019

Resting heart rate and relation to disease and longevity: past, present and future.

Authors:
Magnus T Jensen

Scand J Clin Lab Invest 2019 Feb 14:1-9. Epub 2019 Feb 14.

a Department of Cardiology , Rigshospitalet , Copenhagen, Denmark.

Assessment of heart rate has been used for millennia as a marker of health. Several studies have indicated that low resting heart rate (RHR) is associated with health and longevity, and conversely, a high resting heart to be associated with disease and adverse events. Longitudinal studies have shown a clear association between increase in heart rate over time and adverse events. Read More

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http://dx.doi.org/10.1080/00365513.2019.1566567DOI Listing
February 2019

Measuring calprotectin in plasma and blood with a fully automated turbidimetric assay.

Scand J Clin Lab Invest 2019 Feb 14:1-8. Epub 2019 Feb 14.

a Department of Clinical Chemistry , Trondheim University Hospital , Trondheim , Norway.

Calprotectin in plasma and blood might prove to be a useful biomarker of inflammation and infection; however, automated methods for analysing the concentration of calprotectin in those materials are lacking. We have validated a fully automated turbidimetric method and present health-related reference limits. Calprotectin was measured by Siemens Advia XPT with the Bühlmann fCAL® turbo test (Bühlmann Laboratories AG, Schönenbuch, Switzerland), a particle enhanced turbidimetric immunoassay for quantification of calprotectin in fecal extracts. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1550810DOI Listing
February 2019
1 Read

Analytical performance of automated platelet counts and impact on platelet transfusion guidance in patients with acute leukemia.

Scand J Clin Lab Invest 2019 Feb 14:1-7. Epub 2019 Feb 14.

c Department of Research and Development , Siriraj Center of Research Excellence for Microparticle and Exosome in Diseases, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.

The aim of this study was to evaluate the performance of automated impedance platelet counts by Beckman Coulter LH780 (PLT-LH), Sysmex XN-3000 (PLT-XNi) and fluorescence method by Sysmex XN-3000 (PLT-F) in patients with acute leukemia. Blood specimens were subjected to platelet measurements by evaluated methods and then compared against the international reference method (IRM). Eighty-two blood specimens were included. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2019.1
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http://dx.doi.org/10.1080/00365513.2019.1576100DOI Listing
February 2019
4 Reads

A nine year follow-up study of patients with lymphoedema cholestasis syndrome 1 (LCS1/Aagenaes syndrome).

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):566-574

a Center for Rare Disorders , Oslo University Hospital , Oslo , Norway.

The risks of developing energy or nutrient deficits are of great concern in infants and children with the rare lymphoedema cholestasis syndrome 1 (LCS1)/Aagenaes syndrome. In adolescents and adults, it is not known whether LCS1 patients need specific dietary advice outside periods of cholestasis. The primary objective of the present study was to evaluate the progression of the liver disease and nutritional status in patients with LCS1 over a period of nine years. Read More

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http://dx.doi.org/10.1080/00365513.2018.1519723DOI Listing
February 2019

The influence of oxidative stress on cardiac remodeling in obese adolescents.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):595-600

a Nephrology Department , University Children's Hospital , Belgrade , Serbia.

Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. Read More

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http://dx.doi.org/10.1080/00365513.2018.1528504DOI Listing
February 2019

Glucose variation in centrifuged serum and lithium-heparin gel tubes stored for up to 96 hours at room temperature or 4 °C.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):546-550

b Section of Clinical Biochemistry , University of Verona , Verona , Italy.

This study aimed to verify glucose stability within centrifuged serum and lithium-heparin tubes stored at room temperature (RT) or 4 °C. Sixty paired serum (plus gel separator), lithium-heparin (plus gel separator) and K-EDTA tubes were centrifuged within 30 min from collection. Thirty serum and lithium-heparin tubes were then stored at RT, whilst the other 30 serum and lithium-heparin tubes were kept at 4 °C. Read More

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http://dx.doi.org/10.1080/00365513.2018.1517221DOI Listing
February 2019

Serum sodium level variability as a prognosticator in older adults.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):632-638

a School of Medicine and Dentistry , University of Aberdeen , Aberdeen , UK.

Our aim was to explore biological variation of serum sodium levels as a method of quantifying health risk in older adults. We investigated whether dynamic changes in serum sodium levels could provide additional prognostic information to standard predictors of mortality in older people. Analysis of routinely collected clinical datasets containing information on demographics, hospitalisation, biochemistry, haematology and physical function for Dundee in-patient rehabilitation services, between 1999 and 2011. Read More

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http://dx.doi.org/10.1080/00365513.2018.1543893DOI Listing
February 2019
1 Read

Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):626-631

a Department of General Biochemistry, Faculty of Biology and Environmental Protection , University of Lodz , Lodz , Poland.

Oxidative stress plays the most important role in the pathogenesis of stroke. Extremely low frequency electromagnetic field (ELF-EMF) therapy may be complementary in post-stroke therapy, as it modulates oxidative stress. The aim of this study was to evaluate the messenger ribonucleic acid (mRNA) levels of certain antioxidant genes in post-stroke patients given ELF-EMF therapy. Read More

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http://dx.doi.org/10.1080/00365513.2018.1542540DOI Listing
February 2019

The reference intervals for CA125, CA15-3, CA19-9, CA72-4, AFP, CEA, NSE and CYFRA21-1.

Scand J Clin Lab Invest 2019 Feb 6:1-4. Epub 2019 Feb 6.

a Department of Clinical Laboratory , The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Laboratory Medicine , Zhengzhou , Henan , China.

Tumor markers are noninvasive diagnostic tools for cancer. Their abnormal expression often occurs earlier than clinical symptoms or other detection signals. Appropriate reference intervals (RIs) of tumor markers are important for health evaluation, cancer diagnosis, therapy monitoring and prognosis assessment. Read More

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http://dx.doi.org/10.1080/00365513.2018.1555855DOI Listing
February 2019

Reference limits for GAD65 and IA-2 autoantibodies by chemiluminescence immunoassay in Northern European adults and children.

Scand J Clin Lab Invest 2019 Feb 6:1-3. Epub 2019 Feb 6.

a Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.

The GAD65 and IA-2 antibodies (Abs) are biomarkers of the development of type 1 diabetes mellitus (T1DM) in both children and adults. The upper reference limit for the autoantibodies made by the manufacture was established on an adult Chinese population. Here, we established upper reference limits for Northern European adults and children in accordance with the Clinical and Laboratory Standards Institute (CLSI) guidelines. Read More

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http://dx.doi.org/10.1080/00365513.2019.1566566DOI Listing
February 2019
1 Read

Comparison of thromboelastometry by ROTEM Delta and ROTEM Sigma in women with postpartum haemorrhage.

Scand J Clin Lab Invest 2019 Feb 6:1-7. Epub 2019 Feb 6.

g Department of Hematology , Erasmus University Medical Center , Rotterdam , The Netherlands.

Haemostatic treatment in women experiencing postpartum haemorrhage is increasingly based on point-of-care devices such as ROTEM thromboelastometry. Recently, a fully automated successor of the ROTEM Delta device, the ROTEM Sigma was introduced. To determine whether these devices provide similar results, we compared ROTEM parameters using the ROTEM Delta and Sigma devices in women experiencing postpartum haemorrhage. Read More

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http://dx.doi.org/10.1080/00365513.2019.1571220DOI Listing
February 2019

Increased antibody levels to stage-specific Epstein-Barr virus antigens in systemic autoimmune diseases reveal a common pathology.

Scand J Clin Lab Invest 2019 Feb 6:1-10. Epub 2019 Feb 6.

h Department of Autoimmunology and Biomarkers , Statens Serum Institut , Copenhagen , Denmark.

The immune responses to antigens from different stages of the Epstein-Barr virus (EBV) life cycle were investigated in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS), and systemic sclerosis (SSc) to gain knowledge of EBV's involvement in the etiology of systemic autoimmune diseases (SADs) and for an overview of the humoral immune responses against EBV. Investigations were performed by the use of ELISA. IgM, IgA, and IgG antibody binding to 11 EBV antigens: EBNA1, EBNA2, BALF5, EAD, BALF2, EA/R, VCA p18, VCA p23, gB, gp350, and gp42 were examined in serum pools from SAD patients and healthy controls (HCs). Read More

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http://dx.doi.org/10.1080/00365513.2018.1550807DOI Listing
February 2019
1 Read

Laboratory test based assessment of WHO alcohol risk drinking levels.

Scand J Clin Lab Invest 2019 Feb 5:1-7. Epub 2019 Feb 5.

d National Institute for Health and Welfare (THL) , Helsinki , Finland.

Low-risk thresholds for alcohol use differ across various national guidelines. To assess the novel WHO risk drinking levels in light of alcohol-sensitive common laboratory tests, we analysed biomarkers of liver status, inflammation and lipid profiles from a population-based survey of individuals classified to abstainers and different WHO risk drinking levels defined in terms of mean alcohol consumption per day. The study included 22,327 participants aged 25-74 years from the National FINRISK Study. Read More

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http://dx.doi.org/10.1080/00365513.2019.1571625DOI Listing
February 2019
1 Read

Expression pattern and prognostic implication of SALL4 gene in myeloid leukemias: a case-control study.

Scand J Clin Lab Invest 2019 Jan 12:1-6. Epub 2019 Jan 12.

a Department of Clinical and Chemical Pathology, Faculty of Medicine , Cairo University , Cairo , Egypt.

SALL4 is a transcription factor that retains stem cells in an undifferentiated state and promotes its self-renewal. In addition, it is implicated in leukemogenesis via its effect on leukemic stem cells. This study aimed to characterize the expression pattern of SALL4 gene in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) at different progression phases of the leukemic process and to assess its prognostic significance. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1555854DOI Listing
January 2019
5 Reads

Age- and sex-specific reference values for non-HDL cholesterol and remnant cholesterol derived from the Nordic Reference Interval Project (NORIP).

Scand J Clin Lab Invest 2019 Jan 12:1-4. Epub 2019 Jan 12.

a Department of Medical Sciences , Uppsala University , Uppsala , Sweden.

Objectives: Non-HDL-cholesterol (non-HDL-C) has been reported to be a better marker of cardiovascular risk than LDL-cholesterol (LDL-C) especially in individuals with high triglyceride values. Further, levels of remnant cholesterol have been suggested to in part explain residual risk not captured with LDL-C. The aim of the present study was to define reference values for non-HDL-C and remnant cholesterol based on data from the Nordic Reference Interval Project (NORIP). Read More

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http://dx.doi.org/10.1080/00365513.2018.1550809DOI Listing
January 2019
1 Read

Neutrophil-lymphocyte-ratio distributions in a Danish population from general practice.

Scand J Clin Lab Invest 2019 Jan 12:1-5. Epub 2019 Jan 12.

c Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.

The neutrophil-lymphocyte ratio (NLR) is a novel biomarker, showing promising both diagnostic and prognostic capabilities. The aim of this study was to present NLR distributions in a Danish population from general practice (GP) and compare levels between patients from intensive care units (ICU) and GP. A register-based study was conducted using results from 31,966 blood samples from GP and ICU located in the admission area of Aarhus University Hospital, Denmark. Read More

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http://dx.doi.org/10.1080/00365513.2018.1555856DOI Listing
January 2019
1 Read

A dual-label time-resolved fluorescence immunoassay for screening of osteoporosis based on simultaneous detection of C-terminal telopeptide (β-CTX) and aminoterminal propeptide (P1NP) of type I procollagen.

Scand J Clin Lab Invest 2019 Jan 12:1-6. Epub 2019 Jan 12.

a Department of Orthopaedics, 3rd Affiliated Hospital , Sun Yat-sen University , Guangzhou , China.

Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone. Until a broken bone occurs, there are typically no symptoms. Osteoporosis affects more than 75 million people in the United States, Europe and Japan. Read More

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http://dx.doi.org/10.1080/00365513.2018.1555857DOI Listing
January 2019
1 Read

Performance enhancement of procalcitonin by high-sensitivity C-reactive protein at the optimal cutoff in predicting bacteremia in emergency department adult patients.

Scand J Clin Lab Invest 2019 Jan 10:1-7. Epub 2019 Jan 10.

g Department of Computer Science and Information Engineering , National Central University , Taoyuan , Taiwan.

Pathogenic bacteremia portends a high mortality risk in adult patients admitted to an Emergency Department (ED). This study aims to investigate the effect of adding high-sensitivity C-reactive protein (hs-CRP) to procalcitonin (PCT) and lactate in predicting bacteremia, Gram-negative (GNB) and Gram-positive bacteremia (GPB), using the optimal cutoff derived from the receiver operating characteristics analysis. We evaluated the diagnostic measures, including the positive-test likelihood (LR+), the negative-test likelihood (LR-), and the diagnostic odds ratio (DOR) using a single-center retrospective analysis design. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1550808DOI Listing
January 2019
6 Reads
2.009 Impact Factor

Uncertainty of measurement for 14 immunoassay analytes: application to laboratory result interpretation.

Scand J Clin Lab Invest 2019 Jan 10:1-6. Epub 2019 Jan 10.

a Department of Medical Biochemistry , Ankara University Faculty of Medicine , Ankara , Turkey.

Laboratory tests are an integral part of clinical decision making. Therefore, measurement uncertainty comes into prominence in the context of the accuracy of the laboratory result. This study aims to investigate measurement uncertainty of 14 immunoassay analytes, to compare them with different quality goals and to utilize them in the result interpretation. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1550806DOI Listing
January 2019
16 Reads

Frequency and outcomes of maternal thyroid function abnormalities in early pregnancy.

Scand J Clin Lab Invest 2019 Jan 8:1-9. Epub 2019 Jan 8.

a Department of Clinical Biochemistry , Aalborg University Hospital , Aalborg , Denmark.

Thyroid function in pregnant women is of clinical importance considering the crucial role of thyroid hormones during fetal brain development, but the current level of evidence is insufficient to recommend for or against the routine testing of thyroid function in pregnant women. As part of this debate, it is important to evaluate the frequency of undiagnosed and untreated thyroid function abnormalities in pregnant women and to address challenges related to the biochemical assessment of maternal thyroid function in early pregnancy. A hypothesis of fetal programming by maternal thyroid disease has been proposed, but more evidence in humans is needed to extend the hypothesis and to evaluate child neurodevelopmental outcomes after in utero exposure to different abnormalities in maternal thyroid function. Read More

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http://dx.doi.org/10.1080/00365513.2018.1555858DOI Listing
January 2019
2 Reads

Assessing the impact of inadequate hydration on isotope-GFR measurement.

Scand J Clin Lab Invest 2019 Jan 7:1-5. Epub 2019 Jan 7.

a Departments of Medical Physics and Engineering, Nuclear Medicine and Blood Sciences , The Leeds Teaching Hospitals NHS Trust , Leeds , UK.

Guidelines state that patients undergoing isotope glomerular filtration rate (GFR) tests should maintain adequate hydration, but pragmatically these tests can coincide with procedures requiring the patient not to eat or drink ('nil-by-mouth') for up to 12 hours beforehand. This study investigated the impact of a 12-hour nil-by-mouth regime on GFR measurement. Twelve healthy volunteers were recruited from our institution. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1555859DOI Listing
January 2019
7 Reads

Letter to the Editor False negative results for eosinophils in the 00-19E (Build 5) Information Processing Unit version of automated hematology analyzer sysmex XN series.

Scand J Clin Lab Invest 2019 Jan 2:1-3. Epub 2019 Jan 2.

a Department of Clinical Laboratory , Shandong Provincial Hospital Affiliated to Shandong University , Jinan, 250021 , China.

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1550669DOI Listing
January 2019
10 Reads

Is cardiorespiratory fitness independently associated with the biochemical profile in overweight/obese adults with primary hypertension? The EXERDIET-HTA study.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):613-620. Epub 2018 Nov 24.

d Cardiology Unit , Igualatorio Médico Quirúrgico (IMQ-Amárica) , Vitoria-Gasteiz , Spain.

Cardiorespiratory fitness (CRF) is positively associated with enhanced cardiovascular health. This cross-sectional study aimed to determine associations between CRF and the biochemical profile of overweight/obese adults diagnosed with primary hypertension (HTN). Does cardiorespiratory fitness (exposure) positively affect the biochemical profile (outcome) in overweight/obese individuals suffering from HTN? Assessment with anthropometric, ambulatory blood pressure monitoring (24 h), CRF (peak oxygen uptake, V̇O) and biochemical analysis was performed on 214 participants (138 men, 76 women). Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1531297DOI Listing
November 2018
10 Reads

Technical and diagnostic performance of a new fully automated immunoassay for the determination of intact fibroblast growth factor 23 (FGF23).

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):584-590. Epub 2018 Oct 31.

b Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital RWTH Aachen , Aachen , Germany.

There is growing interest in measuring plasma fibroblast growth factor 23 (FGF23) concentrations in a number of clinical settings. However, a reliable assay with acceptable performance is lacking. Plasma samples of healthy adults and patients with different stages of chronic kidney disease (CKD) were used to compare the precision, recovery, linearity and the pre-analytical stability characteristics of a new fully automated FGF23 (intact) assay with a commercially available FGF23 (intact) ELISA. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1526411DOI Listing
October 2018
3 Reads

Falsely high HbA value due to a novel α1-globin gene mutation: Hb shantou [α127(H10)Lys > Glu; HBA1: c.382 A > G].

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):621-625. Epub 2018 Oct 30.

a Department of Laboratory Medicine , Peking University Shenzhen Hospital , Shenzhen , Guangdong , China.

Hemoglobin A (HbA) is a widely utilized biomarker for the diagnosis and management of diabetes mellitus. Here, we describe an α1-globin chain hemoglobin variant and investigate its effect on HbA measurement. A 26-year-old pregnant woman was suspected to harbor a hemoglobin variant following HbA measurement during a routine prenatal examination using D10 (Bio-Rad). Read More

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http://dx.doi.org/10.1080/00365513.2018.1531298DOI Listing
October 2018
11 Reads
2.010 Impact Factor

Comparison of allergen-specific IgE levels between Immulite 2000 and ImmunoCAP systems against six inhalant allergens and ten food allergens.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):606-612. Epub 2018 Oct 30.

a Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine , The Catholic University of Korea , Seoul , Korea.

In vitro allergen-specific immunoglobulin E (sIgE) measurement has been used as an important diagnostic tool for allergic diseases. Currently, quantitative sIgE levels are detected mainly by using ImmunoCAP and Immulite 2000 assay system. These two systems have the same calibration scale at 0-100 kUA/L, but they differ in used allergens, detection methods and automation systems. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1528506DOI Listing
October 2018
11 Reads

Vitamin D deficiency, insulin resistance and thyroid dysfunction in obese patients: is inflammation the common link?

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):560-565. Epub 2018 Oct 26.

a Department of Endocrinology , Iuliu Haţieganu University of Medicine and Pharmacy , Cluj-Napoca , Romania.

The aim of this article is to study the possible relation of serum vitamin D concentrations to body mass index (BMI), visceral fat thickness (VFT), insulin resistance (IR), inflammation (serum monocyte chemoattractant protein-1 - MCP-1) and thyroid parameters in obese patients. A total of 158 non-diabetic, obese patients aged 19-68 without a history of thyroid pathology were recruited. Biochemical markers, insulin, 25-OH vitamin D, thyroid parameters (TSH, FT3, FT4, TPO antibodies, TG antibodies) and VFT were measured. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1517420DOI Listing
October 2018
9 Reads
2.010 Impact Factor

Influence of mouthwashes on extended exhaled nitric oxide (F) analysis.

Scand J Clin Lab Invest 2018 Oct 22;78(6):450-455. Epub 2018 Oct 22.

a Unit of Clinical Physiology, Helsinki University Central Hospital and University of Helsinki , Helsinki , Finland.

Fractional exhaled nitric oxide (F) is used to assess eosinophilic inflammation of the airways. F values are influenced by the expiratory flow rate and orally produced NO. We measured F at four different expiratory flow levels after two different mouthwashes: tap water and carbonated water. Read More

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http://dx.doi.org/10.1080/00365513.2018.1497802DOI Listing
October 2018
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Status on fasting definition for blood sampling in the Nordic countries - time for a harmonized definition.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):591-594. Epub 2018 Oct 19.

e Department of Clinical Biochemistry and Pharmacology , Odense University Hospital , Odense , Denmark.

The preanalytical phase contains a vast number of practices whose variation may influence the results of laboratory testing and should, therefore, be standardized. The Working Group on Preanalytical Phase of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM WG-PA) has suggested a standardization of venous blood specimen collection (VBSC) requirements for fasting samples including 12 h fasting time and water ad lib in the morning prior to specimen collection. The Nordic Scientific Preanalytical Working Group investigated the fasting definitions used in the Nordic countries. Read More

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http://dx.doi.org/10.1080/00365513.2018.1528503DOI Listing
October 2018
8 Reads

Phenylephrine increases near-infrared spectroscopy determined muscle oxygenation during head-up tilt in men.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):601-605. Epub 2018 Oct 19.

a Copenhagen Muscle Research Centre, Department of Anaesthesia , Rigshospitalet, University of Copenhagen , Copenhagen Ø , Denmark.

Phenylephrine is an α-adrenergic agent and yet seems to increase near-infrared spectroscopy determined muscle oxygenation (SO) that reflects the ratio between oxygenated (OHb) and deoxygenated (Hb) haemoglobin/myoglobin. We examined whether the increase in SO by phenylephrine reflects veno-constriction and to secure filling of the veins, subjects were exposed to head-up tilt (HUT). Phenylephrine (0. Read More

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October 2018
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Effects of the oral, direct factor Xa inhibitor edoxaban on routine coagulation assays, lupus anticoagulant and anti-Xa assays.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):575-583. Epub 2018 Oct 2.

e Department of Clinical and Experimental Medicine , Linköping University , Linköping , Sweden.

Edoxaban is an oral direct factor Xa inhibitor for prophylaxis and treatment of thromboembolic disorders. The effects on common coagulation assays are clinically valuable information and in certain clinical situations a quick assessment of the anticoagulant is wanted. Our aim was to investigate the effect of edoxaban on routine coagulation methods and evaluate anti-Xa assays, commonly used for other direct factor Xa inhibitors, for estimation of the drug concentration. Read More

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http://dx.doi.org/10.1080/00365513.2018.1522664DOI Listing
October 2018
3 Reads

Cytokines and statin therapy in chronic obstructive pulmonary disease patients.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):533-538. Epub 2018 Oct 2.

d Department of Molecular Diagnostics and Flow Cytometry , University Hospital for Infectious Diseases ''Dr. Fran Mihaljevic'' , Zagreb , Croatia.

Cytokines are biological response modifiers involved in the pathophysiology of chronic obstructive pulmonary disease (COPD). This study investigated the potential use of cytokines as disease severity biomarkers in COPD patients and the possible effect of statin therapy on cytokine expression. Possible associations between cytokines, body mass index (BMI) and smoking have also been studied. Read More

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http://dx.doi.org/10.1080/00365513.2018.1514464DOI Listing
October 2018
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Effect of short-term mechanical stimulation on the salivary concentrations of vitamin C, vitamin E, total antioxidant capacity and total oxidant status.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):556-559. Epub 2018 Oct 2.

a Stomatology Department , Universidade Federal do Paraná , Curitiba , Paraná , Brazil.

Oxidative stress biomarkers of oral and systemic diseases can be found in saliva. However, there is no uniformity for the saliva collection time in these kinds of analyses and saliva composition may change because of mechanical stimulation. Therefore, the aim of this work was to determine the effect of mechanical stimulation for 10 min on the concentrations of vitamin C, vitamin E, total antioxidants and total oxidants in saliva. Read More

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http://dx.doi.org/10.1080/00365513.2018.1517419DOI Listing
October 2018
2 Reads

New highly sensitive sandwich ELISA system for soluble endoglin quantification in different biological fluids.

Scand J Clin Lab Invest 2018 Oct 1;78(6):515-523. Epub 2018 Oct 1.

a Hybridoma Technology Laboratory , Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of Russian Federation , Saint Petersburg , Russia.

Soluble endoglin (sEng) is a fragment of a membrane-associated receptor (CD105) expressed on endothelial cells, mesenchymal stem cells and trophoblast cells. It is considered as a regulatory factor involved in the development of preeclampsia (PE) and cancer-associated neo-angiogenesis. The purpose of this study was to describe a new sandwich ELISA for sEng quantification. Read More

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http://dx.doi.org/10.1080/00365513.2018.1516892DOI Listing
October 2018
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Plasma lactate at admission does not predict mortality and complications in hip fracture patients: a prospective observational study.

Scand J Clin Lab Invest 2018 10 1;78(6):508-514. Epub 2018 Oct 1.

b Department of Clinical Sciences , Lund University , Lund , Sweden.

Hip fractures in elderly carry a high mortality. Our objective was to test the hypothesis that plasma lactate concentration at hospital admission can be used to identify patients with a high risk for poor outcome. Hip fracture patients admitted to a university hospital in Sweden from January 2011 to August 2014 in whom a venous lactate was obtained at admission were included in this prospective observational study. Read More

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http://dx.doi.org/10.1080/00365513.2018.1514650DOI Listing
October 2018
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Accuracy evaluation of Roche and Siemens tacrolimus and cyclosporine assays in comparison with liquid chromatography-tandem mass spectrometry.

Scand J Clin Lab Invest 2018 Oct 1;78(6):431-438. Epub 2018 Oct 1.

b Department of Laboratory Medicine , University of Ulsan College of Medicine and Asan Medical Center , Seoul , Korea.

Therapeutic drug monitoring of tacrolimus and cyclosporine is crucial to the success of organ transplantation. We evaluated the analytical performances and accuracy of two commercially available tacrolimus and cyclosporine assays (Roche ISD and Siemens) in comparison with liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total of 342 leftover whole blood samples requested for tacrolimus or cyclosporine assays were stored at -20 °C until analysis. Read More

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http://dx.doi.org/10.1080/00365513.2018.1472801DOI Listing
October 2018
4 Reads

High-dose omega-3 fatty acids have no effect on platelet aggregation or coagulation measured with static and flow-based aggregation instruments and Sonoclot; an observational study in healthy volunteers.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):539-545. Epub 2018 Oct 1.

a Department of Clinical Sciences Lund , Lund University , Lund , Sweden.

The effect of omega-3 fatty acids on platelet aggregation and coagulation is highly unclear. Studies both support and refute the impacts of omega-3 fatty acids on prolonged bleeding time and platelet inhibition as well as its purported positive effects on cardiovascular disease. In a previous pilot study we suggested an inhibition of platelet aggregation measured with multiple electrode aggregometry. Read More

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http://dx.doi.org/10.1080/00365513.2018.1516477DOI Listing
October 2018
2 Reads

Performance evaluation of serum IgG subclass quantification using a SPAPLUS turbidimetric analyzer and comparison with the BNII nephelometer.

Scand J Clin Lab Invest 2018 10 27;78(6):496-500. Epub 2018 Sep 27.

a Department of Laboratory Medicine & Genetics , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea.

IgG consists of four subclasses: IgG1, IgG2, IgG3, and IgG4. Changes in the serum concentration of each subclass reflect different clinical situations, and quantification of each subclass is important to assess patients' clinical states. Herein, we evaluated the analytical performance of the SPAPLUS turbidimetric analyzer (The Binding Site, Birmingham, UK) for IgG subclass. Read More

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http://dx.doi.org/10.1080/00365513.2018.1502464DOI Listing
October 2018
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The significance of thrombophilia in paediatric thromboembolism.

Scand J Clin Lab Invest 2018 Nov - Dec;78(7-8):551-555. Epub 2018 Sep 27.

b Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.

The role of thrombophilia in paediatric thromboembolic disease remains controversial. The objective of the present study was to investigate the prevalence of thrombophilia and other risk factors among children with a thromboembolic event. We systematically examined the medical records and laboratory results of 126 children (≤15 years) referred to Aarhus University Hospital, Denmark with a recent thromboembolic event during 2005-2016. Read More

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http://dx.doi.org/10.1080/00365513.2018.1517418DOI Listing
September 2018
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Challenges in the measurement of plasma creatinine on the Roche cobas c702.

Scand J Clin Lab Invest 2018 10 27;78(6):490-495. Epub 2018 Sep 27.

b Department of Internal Medicine , Viborg Regional Hospital , Viborg , Denmark.

The aim of this study was to document the differences between two Roche creatinine measurement methods, the CREP2 test on the cobas c702 and the CREA PLUS test on the Modular P. Samples with creatinine isotope dilution mass spectrometry (IDMS) values were analyzed on both instruments. Method comparison using the remaining plasma samples was performed twice, using two different lot numbers of reagents and two different lot numbers of calibrators on both instruments. Read More

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http://dx.doi.org/10.1080/00365513.2018.1501090DOI Listing
October 2018
14 Reads