8,346 results match your criteria Scandinavian journal of clinical and laboratory investigation[Journal]


Is cardiorespiratory fitness independently associated with the biochemical profile in overweight/obese adults with primary hypertension? The EXERDIET-HTA study.

Scand J Clin Lab Invest 2018 Nov 24:1-8. Epub 2018 Nov 24.

d Cardiology Unit , Igualatorio Médico Quirúrgico (IMQ-Amárica) , Vitoria-Gasteiz , Spain.

Cardiorespiratory fitness (CRF) is positively associated with enhanced cardiovascular health. This cross-sectional study aimed to determine associations between CRF and the biochemical profile of overweight/obese adults diagnosed with primary hypertension (HTN). Does cardiorespiratory fitness (exposure) positively affect the biochemical profile (outcome) in overweight/obese individuals suffering from HTN? Assessment with anthropometric, ambulatory blood pressure monitoring (24 h), CRF (peak oxygen uptake, V̇O) and biochemical analysis was performed on 214 participants (138 men, 76 women). Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1531297DOI Listing
November 2018
2 Reads

Technical and diagnostic performance of a new fully automated immunoassay for the determination of intact fibroblast growth factor 23 (FGF23).

Scand J Clin Lab Invest 2018 Oct 31:1-7. Epub 2018 Oct 31.

b Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital RWTH Aachen , Aachen , Germany.

There is growing interest in measuring plasma fibroblast growth factor 23 (FGF23) concentrations in a number of clinical settings. However, a reliable assay with acceptable performance is lacking. Plasma samples of healthy adults and patients with different stages of chronic kidney disease (CKD) were used to compare the precision, recovery, linearity and the pre-analytical stability characteristics of a new fully automated FGF23 (intact) assay with a commercially available FGF23 (intact) ELISA. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1526411DOI Listing
October 2018
2 Reads

Falsely high HbA value due to a novel α1-globin gene mutation: Hb shantou [α127(H10)Lys > Glu; HBA1: c.382 A > G].

Scand J Clin Lab Invest 2018 Oct 30:1-5. Epub 2018 Oct 30.

a Department of Laboratory Medicine , Peking University Shenzhen Hospital , Shenzhen , Guangdong , China.

Hemoglobin A (HbA) is a widely utilized biomarker for the diagnosis and management of diabetes mellitus. Here, we describe an α1-globin chain hemoglobin variant and investigate its effect on HbA measurement. A 26-year-old pregnant woman was suspected to harbor a hemoglobin variant following HbA measurement during a routine prenatal examination using D10 (Bio-Rad). Read More

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http://dx.doi.org/10.1080/00365513.2018.1531298DOI Listing
October 2018
1 Read
2.010 Impact Factor

Comparison of allergen-specific IgE levels between Immulite 2000 and ImmunoCAP systems against six inhalant allergens and ten food allergens.

Scand J Clin Lab Invest 2018 Oct 30:1-7. Epub 2018 Oct 30.

a Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine , The Catholic University of Korea , Seoul , Korea.

In vitro allergen-specific immunoglobulin E (sIgE) measurement has been used as an important diagnostic tool for allergic diseases. Currently, quantitative sIgE levels are detected mainly by using ImmunoCAP and Immulite 2000 assay system. These two systems have the same calibration scale at 0-100 kUA/L, but they differ in used allergens, detection methods and automation systems. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1528506DOI Listing
October 2018
6 Reads

Vitamin D deficiency, insulin resistance and thyroid dysfunction in obese patients: is inflammation the common link?

Scand J Clin Lab Invest 2018 Oct 26:1-6. Epub 2018 Oct 26.

a Department of Endocrinology , Iuliu Haţieganu University of Medicine and Pharmacy , Cluj-Napoca , Romania.

The aim of this article is to study the possible relation of serum vitamin D concentrations to body mass index (BMI), visceral fat thickness (VFT), insulin resistance (IR), inflammation (serum monocyte chemoattractant protein-1 - MCP-1) and thyroid parameters in obese patients. A total of 158 non-diabetic, obese patients aged 19-68 without a history of thyroid pathology were recruited. Biochemical markers, insulin, 25-OH vitamin D, thyroid parameters (TSH, FT3, FT4, TPO antibodies, TG antibodies) and VFT were measured. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1517420DOI Listing
October 2018
5 Reads
2.010 Impact Factor

Influence of mouthwashes on extended exhaled nitric oxide (F) analysis.

Scand J Clin Lab Invest 2018 Oct 22;78(6):450-455. Epub 2018 Oct 22.

a Unit of Clinical Physiology, Helsinki University Central Hospital and University of Helsinki , Helsinki , Finland.

Fractional exhaled nitric oxide (F) is used to assess eosinophilic inflammation of the airways. F values are influenced by the expiratory flow rate and orally produced NO. We measured F at four different expiratory flow levels after two different mouthwashes: tap water and carbonated water. Read More

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http://dx.doi.org/10.1080/00365513.2018.1497802DOI Listing
October 2018

Status on fasting definition for blood sampling in the Nordic countries - time for a harmonized definition.

Scand J Clin Lab Invest 2018 Oct 19:1-4. Epub 2018 Oct 19.

e Department of Clinical Biochemistry and Pharmacology , Odense University Hospital , Odense , Denmark.

The preanalytical phase contains a vast number of practices whose variation may influence the results of laboratory testing and should, therefore, be standardized. The Working Group on Preanalytical Phase of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM WG-PA) has suggested a standardization of venous blood specimen collection (VBSC) requirements for fasting samples including 12 h fasting time and water ad lib in the morning prior to specimen collection. The Nordic Scientific Preanalytical Working Group investigated the fasting definitions used in the Nordic countries. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1528503DOI Listing
October 2018
7 Reads

Phenylephrine increases near-infrared spectroscopy determined muscle oxygenation during head-up tilt in men.

Scand J Clin Lab Invest 2018 Oct 19:1-5. Epub 2018 Oct 19.

a Copenhagen Muscle Research Centre, Department of Anaesthesia , Rigshospitalet, University of Copenhagen , Copenhagen Ø , Denmark.

Phenylephrine is an α-adrenergic agent and yet seems to increase near-infrared spectroscopy determined muscle oxygenation (SO) that reflects the ratio between oxygenated (OHb) and deoxygenated (Hb) haemoglobin/myoglobin. We examined whether the increase in SO by phenylephrine reflects veno-constriction and to secure filling of the veins, subjects were exposed to head-up tilt (HUT). Phenylephrine (0. Read More

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http://dx.doi.org/10.1080/00365513.2018.1528505DOI Listing
October 2018

Effects of the oral, direct factor Xa inhibitor edoxaban on routine coagulation assays, lupus anticoagulant and anti-Xa assays.

Scand J Clin Lab Invest 2018 Oct 2:1-9. Epub 2018 Oct 2.

e Department of Clinical and Experimental Medicine , Linköping University , Linköping , Sweden.

Edoxaban is an oral direct factor Xa inhibitor for prophylaxis and treatment of thromboembolic disorders. The effects on common coagulation assays are clinically valuable information and in certain clinical situations a quick assessment of the anticoagulant is wanted. Our aim was to investigate the effect of edoxaban on routine coagulation methods and evaluate anti-Xa assays, commonly used for other direct factor Xa inhibitors, for estimation of the drug concentration. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1522664DOI Listing
October 2018
1 Read

Cytokines and statin therapy in chronic obstructive pulmonary disease patients.

Scand J Clin Lab Invest 2018 Oct 2:1-6. Epub 2018 Oct 2.

d Department of Molecular Diagnostics and Flow Cytometry , University Hospital for Infectious Diseases ''Dr. Fran Mihaljevic'' , Zagreb , Croatia.

Cytokines are biological response modifiers involved in the pathophysiology of chronic obstructive pulmonary disease (COPD). This study investigated the potential use of cytokines as disease severity biomarkers in COPD patients and the possible effect of statin therapy on cytokine expression. Possible associations between cytokines, body mass index (BMI) and smoking have also been studied. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1514464DOI Listing
October 2018
1 Read

Effect of short-term mechanical stimulation on the salivary concentrations of vitamin C, vitamin E, total antioxidant capacity and total oxidant status.

Scand J Clin Lab Invest 2018 Oct 2:1-4. Epub 2018 Oct 2.

a Stomatology Department , Universidade Federal do Paraná , Curitiba , Paraná , Brazil.

Oxidative stress biomarkers of oral and systemic diseases can be found in saliva. However, there is no uniformity for the saliva collection time in these kinds of analyses and saliva composition may change because of mechanical stimulation. Therefore, the aim of this work was to determine the effect of mechanical stimulation for 10 min on the concentrations of vitamin C, vitamin E, total antioxidants and total oxidants in saliva. Read More

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http://dx.doi.org/10.1080/00365513.2018.1517419DOI Listing
October 2018

New highly sensitive sandwich ELISA system for soluble endoglin quantification in different biological fluids.

Scand J Clin Lab Invest 2018 Oct 1:1-9. Epub 2018 Oct 1.

a Hybridoma Technology Laboratory , Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of Russian Federation , Saint Petersburg , Russia.

Soluble endoglin (sEng) is a fragment of a membrane-associated receptor (CD105) expressed on endothelial cells, mesenchymal stem cells and trophoblast cells. It is considered as a regulatory factor involved in the development of preeclampsia (PE) and cancer-associated neo-angiogenesis. The purpose of this study was to describe a new sandwich ELISA for sEng quantification. Read More

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http://dx.doi.org/10.1080/00365513.2018.1516892DOI Listing
October 2018

Plasma lactate at admission does not predict mortality and complications in hip fracture patients: a prospective observational study.

Scand J Clin Lab Invest 2018 Oct 1:1-7. Epub 2018 Oct 1.

b Department of Clinical Sciences , Lund University , Lund , Sweden.

Hip fractures in elderly carry a high mortality. Our objective was to test the hypothesis that plasma lactate concentration at hospital admission can be used to identify patients with a high risk for poor outcome. Hip fracture patients admitted to a university hospital in Sweden from January 2011 to August 2014 in whom a venous lactate was obtained at admission were included in this prospective observational study. Read More

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http://dx.doi.org/10.1080/00365513.2018.1514650DOI Listing
October 2018
1 Read

Accuracy evaluation of Roche and Siemens tacrolimus and cyclosporine assays in comparison with liquid chromatography-tandem mass spectrometry.

Scand J Clin Lab Invest 2018 Oct 1:1-8. Epub 2018 Oct 1.

b Department of Laboratory Medicine , University of Ulsan College of Medicine and Asan Medical Center , Seoul , Korea.

Therapeutic drug monitoring of tacrolimus and cyclosporine is crucial to the success of organ transplantation. We evaluated the analytical performances and accuracy of two commercially available tacrolimus and cyclosporine assays (Roche ISD and Siemens) in comparison with liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total of 342 leftover whole blood samples requested for tacrolimus or cyclosporine assays were stored at -20 °C until analysis. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1472801DOI Listing
October 2018
2 Reads

High-dose omega-3 fatty acids have no effect on platelet aggregation or coagulation measured with static and flow-based aggregation instruments and Sonoclot; an observational study in healthy volunteers.

Scand J Clin Lab Invest 2018 Oct 1:1-7. Epub 2018 Oct 1.

a Department of Clinical Sciences Lund , Lund University , Lund , Sweden.

The effect of omega-3 fatty acids on platelet aggregation and coagulation is highly unclear. Studies both support and refute the impacts of omega-3 fatty acids on prolonged bleeding time and platelet inhibition as well as its purported positive effects on cardiovascular disease. In a previous pilot study we suggested an inhibition of platelet aggregation measured with multiple electrode aggregometry. Read More

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http://dx.doi.org/10.1080/00365513.2018.1516477DOI Listing
October 2018
1 Read

Performance evaluation of serum IgG subclass quantification using a SPAPLUS turbidimetric analyzer and comparison with the BNII nephelometer.

Scand J Clin Lab Invest 2018 Sep 27:1-5. Epub 2018 Sep 27.

a Department of Laboratory Medicine & Genetics , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea.

IgG consists of four subclasses: IgG1, IgG2, IgG3, and IgG4. Changes in the serum concentration of each subclass reflect different clinical situations, and quantification of each subclass is important to assess patients' clinical states. Herein, we evaluated the analytical performance of the SPAPLUS turbidimetric analyzer (The Binding Site, Birmingham, UK) for IgG subclass. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1502464DOI Listing
September 2018
10 Reads

The significance of thrombophilia in paediatric thromboembolism.

Scand J Clin Lab Invest 2018 Sep 27:1-5. Epub 2018 Sep 27.

b Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.

The role of thrombophilia in paediatric thromboembolic disease remains controversial. The objective of the present study was to investigate the prevalence of thrombophilia and other risk factors among children with a thromboembolic event. We systematically examined the medical records and laboratory results of 126 children (≤15 years) referred to Aarhus University Hospital, Denmark with a recent thromboembolic event during 2005-2016. Read More

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http://dx.doi.org/10.1080/00365513.2018.1517418DOI Listing
September 2018
7 Reads

Challenges in the measurement of plasma creatinine on the Roche cobas c702.

Scand J Clin Lab Invest 2018 Sep 27:1-6. Epub 2018 Sep 27.

b Department of Internal Medicine , Viborg Regional Hospital , Viborg , Denmark.

The aim of this study was to document the differences between two Roche creatinine measurement methods, the CREP2 test on the cobas c702 and the CREA PLUS test on the Modular P. Samples with creatinine isotope dilution mass spectrometry (IDMS) values were analyzed on both instruments. Method comparison using the remaining plasma samples was performed twice, using two different lot numbers of reagents and two different lot numbers of calibrators on both instruments. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1501090DOI Listing
September 2018
9 Reads

Plasma choline, homocysteine and vitamin status in healthy adults supplemented with krill oil: a pilot study.

Scand J Clin Lab Invest 2018 Sep 27:1-6. Epub 2018 Sep 27.

a Department of Clinical Science , University of Bergen , Bergen , Norway.

Plasma concentrations of metabolites along the choline oxidation and tryptophan degradation pathways have been linked to lifestyle diseases and dietary habits. This study aimed to investigate how krill oil, a source of ω-3 polyunsaturated fatty acids (PUFAs) with a high phosphatidylcholine content, affected these parameters. The pilot study was conducted as a 28 days intervention in 17 healthy volunteers (18-36 years), who received a supplement of 4. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1512716DOI Listing
September 2018
1 Read

Validation of a simple inductively coupled plasma mass spectrometry method for detecting urine and serum iodine and evaluation of iodine status of pregnant women in Beijing.

Scand J Clin Lab Invest 2018 Sep 27:1-7. Epub 2018 Sep 27.

a Department of Clinical Laboratory , Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China.

Rapid and simple method for serum and urine iodine is necessary for iodine-related diseases. This study aimed to establish and validate a simple and rapid method for quantification of iodine in human urine and serum using inductively coupled plasma mass spectrometry (ICP-MS). Generally, samples were diluted using water with 1. Read More

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http://dx.doi.org/10.1080/00365513.2018.1512150DOI Listing
September 2018
9 Reads

Neutrophil gelatinase-associated lipocalin (NGAL) and cardiovascular events in patients with stable coronary artery disease.

Scand J Clin Lab Invest 2018 Oct 27;78(6):470-476. Epub 2018 Sep 27.

a Department of Cardiology , Aarhus University Hospital , Aarhus , Denmark.

Inflammation is an important mediator in the pathogenesis of atherosclerosis. Neutrophil gelatinase-associated lipocalin (NGAL) is a small glycoprotein secreted by neutrophils. NGAL regulates the activity of matrix metalloproteinase-9, which plays a role in plaque instability. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365513.2018.1
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http://dx.doi.org/10.1080/00365513.2018.1499956DOI Listing
October 2018
1 Read

Intermittent vacuum treatment with VacuMed does not improve peripheral artery disease or walking capacity in patients with intermittent claudication.

Scand J Clin Lab Invest 2018 Oct 27;78(6):456-463. Epub 2018 Sep 27.

b Department of Clinical Research , Nordsjællands Hospital , Hillerød, Denmark.

To assess distal blood pressures (BPs) in ankle and toe, walking capacity, intermittent claudication symptoms, physical activity and self-rated health after intermittent vacuum treatment (IVT) for peripheral artery disease (PAD). Forty-eight patients with PAD were randomised to either a control (C)-group with lifestyle changes or lifestyle changes in combination with VacuMed treatment thrice weekly for 6 weeks. Ankle and toe BPs were measured before, after 6 weeks of intervention and after 6 weeks follow-up. Read More

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http://dx.doi.org/10.1080/00365513.2018.1497803DOI Listing
October 2018

The agreement between capillary and venous sampling for plasma PT/INR results.

Scand J Clin Lab Invest 2018 Sep 27:1-4. Epub 2018 Sep 27.

a Department of Laboratory Medicine , Sundsvall County Hospital , Sundsvall , Sweden.

Regular measurement of prothrombin time (PT) as an international normalized ratio (INR) is of great importance in ensuring a safe Warfarin treatment due to the narrow therapeutic range. Hence, accurate results of the PT/INR analysis are crucial. Due to the high sampling load that patients on Warfarin experience, some prefer capillary sampling (from the tip of the finger) as an alternative to standard venous sampling (from the cubital fossa). Read More

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http://dx.doi.org/10.1080/00365513.2018.1488178DOI Listing
September 2018
8 Reads

Divergent effects on macrophage biomarkers soluble CD163 and CD206 in axial spondyloarthritis.

Scand J Clin Lab Invest 2018 Sep 4:1-7. Epub 2018 Sep 4.

a Department of Biomedicine , Aarhus University , Aarhus , Denmark.

The chronic joint inflammation in axial spondyloarthritis (axSpA) is characterized by infiltration of activated macrophages. The haptoglobin-hemoglobin receptor CD163 and the mannose receptor CD206 are strongly expressed on M2c and M2a macrophages, respectively. We measured the soluble forms of the receptors (sCD163 and sCD206) in plasma (PL) in two axSpA cohorts. Read More

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http://dx.doi.org/10.1080/00365513.2018.1500704DOI Listing
September 2018
7 Reads

Carotid intima media thickness and ankle brachial index are inversely associated in subjects with and without diabetes.

Scand J Clin Lab Invest 2018 Aug 3:1-6. Epub 2018 Aug 3.

d Department of Clinical Research , Nordsjællands Hospital-Hillerød , Hillerød , Denmark.

Carotid intima-media thickness (IMT) and ankle brachial index (ABI) are non-invasive indicators of generalised atherosclerosis. The aim was to determine the association between carotid IMT and ABI in subjects with and without diabetes mellitus (DM), and to analyse specific age change-points. We included 2744 subjects from the Copenhagen City Heart Study (mean age (SD) 56. Read More

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http://dx.doi.org/10.1080/00365513.2018.1499124DOI Listing
August 2018
1 Read

Comparison of second- and third-generation immunoassays for detection of anti-cyclic citrullinated peptide antibodies.

Scand J Clin Lab Invest 2018 Aug 3:1-6. Epub 2018 Aug 3.

c Department of Internal Medicine , Konkuk University School of Medicine , Seoul , Korea.

Anti-cyclic citrullinated peptide antibodies (anti-CCPs) are important diagnostic markers for rheumatoid arthritis (RA). We evaluated the analytical and clinical performance of the QUANTA Flash CCP3 (INOVA Diagnostics, USA), a fully automated third-generation anti-CCP assay, in comparison with three second-generation anti-CCP (CCP2) assays. A total of 300 sera (67 from RA patients, 64 from other rheumatic diseases, 43 from osteoarthritis [OA], and 126 from other conditions) were tested with QUANTA Flash CCP3, Kallestad Anti-CCP II (Bio-Rad, USA), Elecsys Anti-CCP (Roche Diagnostics GmbH, Germany), and ARCHITECT Anti-CCP (Abbott Diagnostics, USA). Read More

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http://dx.doi.org/10.1080/00365513.2018.1499957DOI Listing

The relationship of serum VEGF and sVEGFR-1 levels with vascular involvement in patients with Behçet's disease.

Scand J Clin Lab Invest 2018 Jul 17:1-7. Epub 2018 Jul 17.

a Department of Medical Biochemistry , University of Health Sciences, Gülhane School of Medicine , Ankara , Turkey.

Behçet's disease (BD) is a rare, chronic, inflammatory disorder characterized by multisystemic vasculitis including mucocutaneous, neurologic, and ophthalmic involvement. Our aim is to compare vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) levels in BD, among the patients having or not having organ involvement, disease activation and especially vascular involvement. Fifty-five patients with BD, 25 of which were accompanied by vascular involvement, and 31 control subjects were included in the study. Read More

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http://dx.doi.org/10.1080/00365513.2018.1488179DOI Listing
July 2018
6 Reads

New HPLC instrument performance evaluation in HbA determination and comparison with capillary electrophoresis.

Scand J Clin Lab Invest 2018 Sep 11;78(5):393-397. Epub 2018 Jul 11.

a Department of Experimental Medicine and Surgery , "Tor Vergata" University Hospital , Rome , Italy.

Glycated hemoglobin (HbA) measurement provides the most important medium to long-term marker of time-averaged glycemic status. Its relationship to clinical outcome in diabetes has been convincingly demonstrated for both type 1 and type 2 diabetes. The main HbA measurement methods for clinical routine are as follows: ion-exchange chromatography; affinity chromatography, capillary electrophoresis, immunoassay and enzymatic methods. Read More

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http://dx.doi.org/10.1080/00365513.2018.1487072DOI Listing
September 2018
5 Reads

A precise, sensitive and stable LC-MSMS method for detection of picomolar levels of serum aldosterone.

Scand J Clin Lab Invest 2018 Sep 9;78(5):379-385. Epub 2018 Jul 9.

a Department of Medical Biochemistry , St Olavs Hospital, Trondheim University Hospital , Trondheim , Norway.

Background: Accurate quantification of aldosterone is essential in the diagnosis of primary aldosteronism. Liquid chromatography-tandem mass spectrometry (LC-MSMS) analysis is increasingly being used to improve analytical sensitivity and specificity, since this technology reduces most of the interferences observed with immunological methods.

Methods: Serum samples with d-aldosterone as internal standard were extracted with methyl tert-butyl ether, using liquid-liquid extraction (LLE). Read More

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http://dx.doi.org/10.1080/00365513.2018.1480060DOI Listing
September 2018
2 Reads

D-dimer during pregnancy: establishing trimester-specific reference intervals.

Scand J Clin Lab Invest 2018 Jul 5:1-4. Epub 2018 Jul 5.

a Biochemistry Department , Hospital General Universitario Santa Lucía , Cartagena , Spain.

Pregnancy is associated with an increased risk of venous thromboembolism (VTE). D-dimer is a biomarker used as an exclusion criterion of VTE disease, but its usefulness during pregnancy shows limitations because D-dimer levels physiologically increase through pregnancy. The aim of our study was to follow the changes of D-dimer levels and to establish trimester-specific reference intervals during normal pregnancy. Read More

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http://dx.doi.org/10.1080/00365513.2018.1488177DOI Listing
July 2018
2 Reads

Five-year observation of the relationship between body mass index and glycated hemoglobin in children with Type 1 diabetes mellitus.

Scand J Clin Lab Invest 2018 Sep 2;78(5):398-406. Epub 2018 Jul 2.

a Department of Pediatrics, Endocrinology, Diabetology with Cardiology Divisions , Medical University of Bialystok , Poland.

Background: Poor metabolic control is a well-recognized risk factor for cardiovascular disease. However, the relationship between such factor as body weight and metabolic control in children with diabetes mellitus type 1 (DM1) is unclear. The aim of this study was to examine the relationships between body weight, age, metabolic control, sex, and form of insulin therapy in children with DM1. Read More

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http://dx.doi.org/10.1080/00365513.2018.1487073DOI Listing
September 2018
5 Reads

High-sensitivity troponin I in persistent atrial fibrillation - relation to NT-proBNP and markers of inflammation and haemostasis.

Scand J Clin Lab Invest 2018 Sep 22;78(5):386-392. Epub 2018 Jun 22.

a Department of Medical Research , Baerum Hospital, Vestre Viken Hospital Trust , Drammen , Norway.

Purpose: As cardiac troponins emerge as prognostic markers in atrial fibrillation (AF), it is important to identify mechanisms initiating and perpetuating cardiac troponin release, including its relations to other circulating biomarkers, in AF populations. We studied associations between high-sensitivity troponin I (hs-TnI) and markers representing myocardial wall tension, inflammation and haemostasis in persistent AF.

Methods: In a double blind, placebo-controlled study, 171 patients referred for electrical cardioversion for persistent AF were randomised to receive candesartan or placebo for 3-6 weeks before and 6 months after cardioversion. Read More

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http://dx.doi.org/10.1080/00365513.2018.1481224DOI Listing
September 2018
2 Reads

Verification study on the NORIP LDH reference intervals with a proposed new upper reference limit.

Scand J Clin Lab Invest 2018 Sep 13;78(5):421-427. Epub 2018 Jun 13.

a Department of Clinical Biochemistry , Copenhagen University Hospital of Nordsjælland , Denmark.

We verified the lactate dehydrogenase (LDH) reference interval (RI) provided by the Nordic Reference Interval Project (NORIP). The serum LDH concentration was analysed on the Dimension Vista 1500 system with an IFCC method with a bias of +2.1 % and +2. Read More

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http://dx.doi.org/10.1080/00365513.2018.1481223DOI Listing
September 2018
1 Read

Hygiene of venepuncture tourniquets in Denmark.

Scand J Clin Lab Invest 2018 Sep 10;78(5):417-420. Epub 2018 Jun 10.

a Department of Clinical Biochemistry and Pharmacology , Odense University Hospital , Odense , Denmark.

Tourniquets are widely used to make the vein more visible prior to blood collection. Venepuncture tourniquets are however a non-sterile and potentially reusable equipment. Several studies have shown that they are colonised by a variety of pathogenic bacteria and consecutively use of the same tourniquet on multiple patients will increase the risk of a nosocomial infection. Read More

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http://dx.doi.org/10.1080/00365513.2018.1480799DOI Listing
September 2018
1 Read

Association between elevated plasma microRNA-223 content and severity of coronary heart disease.

Scand J Clin Lab Invest 2018 Sep 10;78(5):373-378. Epub 2018 Jun 10.

b Department of Intensive Medicine , Hongqi Hospital, Mudanjiang Medical University , Mudanjiang , China.

Bioinformatics indicate that miR-223 regulates many genes associated with cholesterol metabolism, and it could also control high-density lipoprotein-cholesterol (HDL-C) uptake. As reported in previous study, miR-223 was found to be upregulated from human subjects with familial hypercholesterolaemia, however, it remains to be determined using a larger group of coronary heart disease (CHD) patients. Moreover, whether it correlates with severity of atherogenesis, has never been elucidated before. Read More

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http://dx.doi.org/10.1080/00365513.2018.1480059DOI Listing
September 2018
4 Reads

Determination of fetal RHD type in plasma of RhD negative pregnant women.

Scand J Clin Lab Invest 2018 Sep 5;78(5):411-416. Epub 2018 Jun 5.

a Department of Immunology and Transfusion Medicine , Oslo University Hospital , Oslo , Norway.

Alloimmunization against the RhD antigen is the most common cause of hemolytic disease of the fetus and newborn. Antenatal anti-D prophylaxis in addition to postnatal anti-D prophylaxis reduces the number of RhD-immunizations compared to only postnatal administration. Cell-free fetal DNA released from the apoptotic trophoblastic placental cells into the maternal circulation can be used to determine the fetal RHD type in a blood sample from an RhD negative mother. Read More

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http://dx.doi.org/10.1080/00365513.2018.1475681DOI Listing
September 2018
16 Reads

Pediatric reference intervals for general clinical chemistry components - merging of studies from Denmark and Sweden.

Scand J Clin Lab Invest 2018 Sep 28;78(5):365-372. Epub 2018 May 28.

e Fürst Medical Laboratory , Oslo , Norway.

Background: Reference intervals are crucial tools aiding clinicians when making medical decisions. However, for children such values often are lacking or incomplete. The present study combines data from separate pediatric reference interval studies of Denmark and Sweden in order to increase sample size and to include also pre-school children who were lacking in the Danish study. Read More

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http://dx.doi.org/10.1080/00365513.2018.1474493DOI Listing
September 2018
1 Read

Warfarin monitoring with viscoelastic haemostatic assays, thrombin generation, coagulation factors and correlations to Owren and Quick prothrombin time.

Scand J Clin Lab Invest 2018 Sep 23;78(5):358-364. Epub 2018 May 23.

a Department of Anesthesia and Intensive Care , Clinical Sciences Lund, Lund University, Sweden and Skåne University Hospital Lund , Lund , Sweden.

The anticoagulant warfarin is commonly monitored with prothrombin time (PT). Viscoelastic haemostatic assays (VHA) are primarily used in situations of acute bleeding to guide haemostatic therapy. Much research has focused on VHA monitoring of new oral anticoagulants. Read More

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http://dx.doi.org/10.1080/00365513.2018.1474492DOI Listing
September 2018
4 Reads

What everybody should know about postural changes.

Scand J Clin Lab Invest 2018 Sep 22;78(5):407-410. Epub 2018 May 22.

b IRCCS Istituto Ortopedico Galeazzi , Milano , Italia.

Posture changes have been known for a long time to influence the concentration of many analytes in blood especially macromolecules. It is very clear that when someone switches from supine to sitting or standing or from sitting to standing a hemoconcentration is induced. Similarly, when someone switches from standing to sitting or lying a hemodilution occurs. Read More

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http://dx.doi.org/10.1080/00365513.2018.1473634DOI Listing
September 2018
1 Read

Serum cystatin C as an early predictor of acute kidney injury in preterm neonates with respiratory distress syndrome.

Scand J Clin Lab Invest 2018 Sep 22;78(5):352-357. Epub 2018 May 22.

c Ministry of Health , Cairo , Egypt.

Preterm neonates with respiratory distress syndrome (RDS) are at increased risk of acute kidney injury (AKI). Our study aimed at determining whether serum cystatin C (sCysC) on day 3 of life (D3) can early predict AKI in preterm neonates with RDS. This prospective study was conducted on 75 preterm neonates; 50 with RDS and 25 without RDS. Read More

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http://dx.doi.org/10.1080/00365513.2018.1472803DOI Listing
September 2018
3 Reads

Biological variables influencing the estimation of reference limits.

Scand J Clin Lab Invest 2018 Sep 15;78(5):337-345. Epub 2018 May 15.

c Bremer Zentrum für Laboratoriumsmedizin Klinikum Bremen Mitte , Bremen , Germany.

Reference limits (RLs) are required to evaluate laboratory results for medical decisions. The establishment of RL depends on the pre-analytical and the analytical conditions. Furthermore, biological characteristics of the sub-population chosen to provide the reference samples may influence the RL. Read More

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http://dx.doi.org/10.1080/00365513.2018.1471617DOI Listing
September 2018
1 Read

Hemolysis may cause false negative results and underdiagnosis of celiac disease when measuring anti-tissue transglutaminase antibodies in serum by immunoassays.

Scand J Clin Lab Invest 2018 09 15;78(5):428-429. Epub 2018 May 15.

a Department of Clinical Biochemistry , Hvidovre Hospital , Hvidovre , Denmark.

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http://dx.doi.org/10.1080/00365513.2018.1472802DOI Listing
September 2018
1 Read

Wide-range CRP versus high-sensitivity CRP on Roche analyzers: focus on low-grade inflammation ranges and high-sensitivity cardiac troponin T levels.

Scand J Clin Lab Invest 2018 Sep 15;78(5):346-351. Epub 2018 May 15.

a Department of Metabolic Biochemistry , Pitié Salpêtrière-Charles Foix University Hospital (AP-HP) , Paris , France.

Wide-range C-reactive protein (wr-CRP) has been proposed as an economical alternative to high-sensitivity C-reactive protein (hs-CRP) for the evaluation of low-grade inflammation-associated cardiovascular risk (LGI-CVR). Concomitant values of serum hs-CRP and plasma wr-CRP ≤5 mg/L, and high-sensitivity cardiac troponin T (hs-cTnT), all assayed on Roche Diagnostics analyzers over a 1.8-year period, were extracted from a hospital laboratory database. Read More

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http://dx.doi.org/10.1080/00365513.2018.1471618DOI Listing
September 2018
5 Reads
2.010 Impact Factor

Estimation of metabolic factors related to insulin resistance and metabolic syndrome in young people.

Scand J Clin Lab Invest 2018 07 9;78(4):325-332. Epub 2018 May 9.

c Department of Toxicology, Faculty of Pharmacy with Division of Laboratory Diagnostics , Wroclaw Medical University , Wroclaw , Poland.

Civilizational developments occurring during recent decades have resulted in an increased incidence of a variety of metabolic disorders related to insulin resistance in younger people. The determination of decision limits for insulin resistance indices, especially among young people, is a significant challenge in clinical practice. The aim of this study was the estimation of metabolic factors related to their relationship to insulin resistance and metabolic syndrome (MS) features in young, apparently healthy people. Read More

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http://dx.doi.org/10.1080/00365513.2018.1469787DOI Listing
July 2018
4 Reads

Changes in red blood cell volume during transition of heart failure status: a reflection of cellular hydration status?

Authors:
Hajime Kataoka

Scand J Clin Lab Invest 2018 07 27;78(4):305-311. Epub 2018 Apr 27.

a Internal Medicine , Nishida Hospital , Oita , Japan.

This study examined how changes in heart failure (HF) status induce changes in the index of erythrocyte hydration based on mean red blood cell volume (MCV). Data from 47 HF patients (32% men; 78.2 ± 9. Read More

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http://dx.doi.org/10.1080/00365513.2018.1466607DOI Listing
July 2018
2 Reads

Significance of asymptomatic hyperuricemia in patients after coronary events.

Scand J Clin Lab Invest 2018 07 27;78(4):312-317. Epub 2018 Apr 27.

f Veterans Affairs Medical Center Washington USA , Washington , DC , USA.

The goal of the present study was to determine the prevalence of hyperuricemia in patients with coronary artery disease (CAD), within three months after coronary events. Also, we aimed to determine whether the presence of hyperuricemia holds correlation with severe CAD, overall heart functioning and risk factors for CAD. The study included 505 consecutive CAD patients, 385 males and 120 females, aged 60. Read More

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http://dx.doi.org/10.1080/00365513.2018.1467035DOI Listing
July 2018
2 Reads
2.010 Impact Factor

Relationship between circulating miRNA-30e and no-reflow phenomenon in STEMI patients undergoing primary coronary intervention.

Scand J Clin Lab Invest 2018 07 27;78(4):318-324. Epub 2018 Apr 27.

a Department of Cardiology , The First Affiliated Hospital of Guangxi Medical University , 6 Shuangyong Road, Nanning, 530021 , China.

To investigate the relationship between miRNA-30e level in circulation and no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction (STEMI) during primary percutaneous coronary intervention (pPCI). A total of 255 consecutive patients with STEMI undergoing pPCI were enrolled in this study. These patients were divided into two groups according to the occurrence of reflow during pPCI, namely normal-reflow group with 214 cases and no-reflow group with 41 cases. Read More

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http://dx.doi.org/10.1080/00365513.2018.1467571DOI Listing
July 2018
1 Read

Insulin resistance is associated with larger thyroid volume in adults with type 1 diabetes independently from presence of thyroid autoimmunity.

Scand J Clin Lab Invest 2018 07 19;78(4):287-292. Epub 2018 Apr 19.

a Department of Internal Medicine and Diabetology , Poznan University of Medical Sciences , Poznan , Poland.

To investigate the effect of insulin resistance (IR) on thyroid function, thyroid autoimmunity (AIT) and thyroid volume in type 1 diabetes (T1DM). 100 consecutive patients with T1DM aged 29 (±6) years with diabetes duration 13 (±6) years were included. Exclusion criteria were: history of thyroid disease, current treatment with L-thyroxin or anti-thyroid drugs. Read More

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http://dx.doi.org/10.1080/00365513.2018.1455221DOI Listing
July 2018
2 Reads

Establishing cut-offs for urine erythrocyte and leukocyte dipstick tests.

Scand J Clin Lab Invest 2018 07 18;78(4):301-304. Epub 2018 Apr 18.

b Department of Laboratory Medicine , Hallym University College of Medicine , Hwaseong , Korea.

Urine erythrocyte (Ery) and leukocyte (Leu) dipstick tests are essential for detecting microhematuria and urinary tract infection. Currently, there is no suggestion for establishing the cut-off limits in an ordinal scale test. This study aimed to establish the cut-off limits for urine Ery and Leu dipstick tests via probit regression. Read More

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http://dx.doi.org/10.1080/00365513.2018.1463559DOI Listing
July 2018
6 Reads

Development of large-scale manufacturing of adipose-derived stromal cells for clinical applications using bioreactors and human platelet lysate.

Scand J Clin Lab Invest 2018 07 17;78(4):293-300. Epub 2018 Apr 17.

a Cardiology Stem Cell Centre, The Heart Centre, Rigshospitalet Copenhagen University Hospital , Copenhagen , Denmark.

In vitro expanded adipose-derived stromal cells (ASCs) are a useful resource for tissue regeneration. Translation of small-scale autologous cell production into a large-scale, allogeneic production process for clinical applications necessitates well-chosen raw materials and cell culture platform. We compare the use of clinical-grade human platelet lysate (hPL) and fetal bovine serum (FBS) as growth supplements for ASC expansion in the automated, closed hollow fibre quantum cell expansion system (bioreactor). Read More

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http://dx.doi.org/10.1080/00365513.2018.1462082DOI Listing
July 2018
4 Reads