7,003 results match your criteria Scandinavian Journal of Immunology[Journal]


Chronic inflammation during Osteoarthritis is associated with an increased expression of CD161 during advanced stage.

Scand J Immunol 2019 Apr 24:e12770. Epub 2019 Apr 24.

Department of Anatomy, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Increasing evidence suggests a role of inflammation during the pathogenesis of Osteoarthritis (OA). The local and systemic inflammation was studied in 33 patients of different KL grades, grade2 (n=11), grade3 (n=6) and grade4 (n=16). The levels of cytokines, adipokines, and matrixmetalloproteinases (MMPs) were measured in serum and synovial fluid (SF) by flow cytometry and ELISA respectively. Read More

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http://dx.doi.org/10.1111/sji.12770DOI Listing
April 2019
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MF59 adjuvant enhances the immunogenicity and protective immunity of the OmpK/Omp22 fusion protein from Acineterbacter baumannii through intratracheal inoculation in mice.

Scand J Immunol 2019 Apr 21:e12769. Epub 2019 Apr 21.

Institute of Immunology and Molecular Biology, North Sichuan Medical College, Nanchong, 637000, People's Republic of China.

Acinetobacter baumannii (A. baumannii) is an emerging nosocomial pathogenic bacterium which leads to hospital infections. The increase of drug-resistant A. Read More

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Heterogeneous macrophages: supersensors of exogenous inducing factors.

Scand J Immunol 2019 Apr 19:e12768. Epub 2019 Apr 19.

School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi, 330006, China.

As heterogeneous immune cells, macrophages mount effective responses to various internal and external changes during disease progression. Macrophage polarization, rather than macrophage heterogenization, is often used to describe the functional differences between macrophages. While macrophage polarization partially contributes to heterogeneity, it does not completely explain the concept of macrophage heterogeneity. Read More

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April 2019
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Interleukin-21 enhances Toll-like receptor 2/4-mediated cytokine production via phosphorylation in the STAT3, Akt and p38 MAPK signalling pathways in human monocytic THP-1 cells.

Scand J Immunol 2019 Apr 11:e12761. Epub 2019 Apr 11.

Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China.

Interleukin-21 (IL-21) is a type I cytokine produced by activated T cells that promotes cytokine production in monocytes. Monocytes are activated by Toll-like receptors (TLRs) to produce pro-inflammatory mediators. However, little is known about the regulatory effect of IL-21 on TLR-mediated inflammation in human monocytes. Read More

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http://dx.doi.org/10.1111/sji.12761DOI Listing

Genetic and molecular findings of 38 Iranian patients with chronic granulomatous disease caused by p47-phox defect.

Scand J Immunol 2019 Apr 8:e12767. Epub 2019 Apr 8.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

One of the components of NADPH oxidase is p47-phox, encoded by NCF1 gene. This study aims to find new genetic changes and clinical features in 38 Iranian patients with autosomal recessive chronic granulomatous disease (AR-CGD) caused by NCF1 gene defect. Patients who had abnormal NBT and DHR-1,2,3 assay with loss of p47-phox in Western blotting were included in this study. Read More

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http://dx.doi.org/10.1111/sji.12767DOI Listing
April 2019
4 Reads

miR-378a Modulates Macrophage Phagocytosis and Differentiation through Targeting CD47-SIRPα Axis in Atherosclerosis.

Scand J Immunol 2019 Mar 31:e12766. Epub 2019 Mar 31.

Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, China.

Background: Signal regulatory protein alpha (SIRPa) is an essential signalling molecule that modulates inflammatory responses in macrophages. However, the regulation of SIRPs and its dynamic changes in macrophages under inflammatory stimulation in atherosclerosis remain uncertain.

Objective: The study aimed to identify the miRNAs that regulate SIRPa transcription and their roles in modulating phagocytosis, differentiation and cholesterol efflux in macrophages. Read More

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Circulating CD137 CD8 T cells accumulate along with increased functional regulatory T cells and thoracic tumour burden in lung cancer patients.

Scand J Immunol 2019 Mar 28:e12765. Epub 2019 Mar 28.

Department of Medical Oncology, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing, China.

CD137 is a promising target for immunostimulation strategies against cancer. Previous studies showed that CD137 CD8 T cells are enriched in antitumour effector T cells in both preclinical tumour models and cancer patients, but to date, such T cells in the blood of lung cancer patients have not been sufficiently investigated. In this study, circulating antigen-activated CD8 T cell subsets, identified as CD137 CD8 or PD-1 (programmed cell death protein 1) CD8 , and regulatory T cells (Treg), identified as CD4 CD25 CD127 , in 40 untreated lung cancer patients and in 49 age- and sex-matched healthy controls (HCs) were assessed by flow cytometry. Read More

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March 2019
1.882 Impact Factor

Hepatic serum amyloid A1 upregulates interleukin-17 (IL-17) in γδ T cells through Toll-like receptor 2 and is associated with psoriatic symptoms in transgenic mice.

Scand J Immunol 2019 Mar 20:e12764. Epub 2019 Mar 20.

School of Life Science, BK21 Plus KNU Creative Bioresearch Group, Kyungpook National University, Daegu, Korea.

Serum amyloid A (SAA) is an acute phase protein with pro-inflammatory cytokine-like properties. Recent studies have revealed that SAA promoted interleukin-17 (IL-17) production by various cells, including γδ T cells. γδ T cells are innate immune cells and express Toll-like receptor 2 (TLR2) on their surface, which is one of the SAA receptors. Read More

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http://dx.doi.org/10.1111/sji.12764DOI Listing
March 2019
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Challenges in investigating patients with isolated decreased serum IgM: The SIMcal study.

Scand J Immunol 2019 Mar 18:e12763. Epub 2019 Mar 18.

Department of Tranzo, Tilburg University, Tilburg, the Netherlands.

The clinical consequences of isolated decreased serum immunoglobulin (Ig)M are not sufficiently known. Therefore, it is difficult to determine the clinical policy following such a finding. Only few reported IgM-deficient patients fulfil the European Society for Immunodeficiencies (ESID) diagnostic criteria for selective IgM deficiency (true sIgMdef), or their diagnosis is uncertain due to insufficient laboratory data (possible sIgMdef). Read More

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http://dx.doi.org/10.1111/sji.12763DOI Listing
March 2019
1.882 Impact Factor

The history of the two-signal model of lymphocyte activation: A personal perspective.

Scand J Immunol 2019 Mar 1:e12762. Epub 2019 Mar 1.

Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

The first ideas leading to The Two-Signal Model of lymphocyte activation were published 50 years ago, but the model was not realized in one sitting. I describe the three phases that led to its contemporary formulations. A motivation underlying all these models was to generate a minimal description of what is required for antigen to inactivate and activate mature lymphocytes that, at the same time, accounts for how peripheral tolerance is achieved. Read More

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http://dx.doi.org/10.1111/sji.12762DOI Listing
March 2019
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Molecular model linking Th2 polarized M2 tumour-associated macrophages with deaminase-mediated cancer progression mutation signatures.

Scand J Immunol 2019 May 18;89(5):e12760. Epub 2019 Mar 18.

GMDxCo Pty Ltd, Melbourne, Victoria, Australia.

A new and diverse range of somatic mutation signatures are observed in late-stage cancers, but the underlying reasons are not fully understood. We advance a "combinatorial association model" for deaminase binding domain (DBD) diversification to explain the generation of previously observed cancer-progression associated mutation signatures. We also propose that changes in the polarization of tumour-associated macrophages (TAMs) are accompanied by the expression of deaminases with a new and diverse range of DBDs, and thus accounting for the generation of new somatic mutation signatures. Read More

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http://dx.doi.org/10.1111/sji.12760DOI Listing
May 2019
3 Reads
1.882 Impact Factor

Skewed B cell receptor repertoire and reduced antibody avidity in patients with DOCK8 deficiency.

Scand J Immunol 2019 Feb 21:e12759. Epub 2019 Feb 21.

Division of Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.

DOCK8 immunodeficiency syndrome (DIDS) is a combined immunodeficiency characterized by recurrent viral infections, severe atopy and early onset malignancy. Immunological abnormalities include lymphopenia, CD8 T-cell cytoskeleton dysfunction, defective B cell memory and variable serum immunoglobulin levels. Here, we analyse the B cell receptor repertoire (BCR) characteristics and antibody avidity of four DIDS patients, attempt to understand the dysregulated humoral immunity in DIDS patients with a normal antibody titre and suggest a scientific basis for intravenous immunoglobulin (IVIG) replacement therapy for these patients. Read More

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http://dx.doi.org/10.1111/sji.12759DOI Listing
February 2019

Associations between FCGR polymorphisms and immune thrombocytopenia: A meta-analysis.

Scand J Immunol 2019 May 18;89(5):e12758. Epub 2019 Mar 18.

Clinical Laboratory, Henan People's Hospital, Zhengzhou, China.

Several studies already explored associations between Fc gamma receptor (FCGR) polymorphisms and immune thrombocytopenia (ITP), but the results of these studies were not consistent. Consequently, we conducted a meta-analysis of relevant studies to better analyse the effects of FCGR polymorphisms on individual susceptibility to ITP. PubMed, Web of Science, Embase and CNKI were searched for eligible studies. Read More

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http://dx.doi.org/10.1111/sji.12758DOI Listing

Interferon-γ facilitated adjuvant-induced arthritis at early stage.

Scand J Immunol 2019 May 11;89(5):e12757. Epub 2019 Mar 11.

Department of Rheumatology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Background And Aim: Interferon-γ (IFN-γ) is a versatile cytokine which broadly involves in the inflammatory diseases, mediating both immune activation and tolerance. Here, we aimed to investigate the role of IFN-γ in the initiation of adjuvant-induced arthritis (AIA).

Methods And Results: In an AIA mice model, increasing IFN-γ mRNA was observed at day 3 and peaked on day 7. Read More

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http://dx.doi.org/10.1111/sji.12757DOI Listing

The role of immunity in the pathogenesis and development of preeclampsia.

Authors:
Hui-Qing Lu Rong Hu

Scand J Immunol 2019 Feb 9:e12756. Epub 2019 Feb 9.

Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China.

Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality, however, the aetiology of preeclampsia still remains unclear. It has been widely accepted that the disease results from insufficient spiral artery remodelling, leading to placental ischaemia and the release of a variety of factors. In recent decades, a large number of studies have observed an abnormal immune response in preeclamptic women and studies of both patients and animal models have shown alterations in the function or the number of immune agents. Read More

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http://dx.doi.org/10.1111/sji.12756DOI Listing
February 2019
2 Reads

Kinetics of Helios(+) and Helios(-) T regulatory cell subsets in the circulation of healthy pregnant women.

Scand J Immunol 2019 Apr 4;89(4):e12754. Epub 2019 Mar 4.

Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.

Regulatory T cells (Tregs) play a critical role in the maintenance of a pregnancy. While the kinetics of the number of peripheral blood Tregs has been satisfactorily described in mouse models, analysis of these cell populations in human pregnancy is complicated by high variability in the quantity of Tregs and inconsistencies in the markers used for detecting different types of Treg. In the light of this, we set out to investigate the kinetics of various types of Treg, including CD45RA, GARP and PD-1(+) Tregs, in the peripheral blood of pregnant women in the first, second and third trimester, and at the time of delivery. Read More

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http://dx.doi.org/10.1111/sji.12754DOI Listing

Tim-3 regulates inflammatory cytokine expression and Th17 cell response induced by monocytes from patients with chronic hepatitis B.

Scand J Immunol 2019 May 18;89(5):e12755. Epub 2019 Mar 18.

Department of Infectious Disease, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Tim-3 is expressed on monocytes/macrophages and is involved in the regulation of inflammatory responses. The aim of this study was to determine the effect of Tim-3 on inflammatory response triggered by peripheral monocytes from patients with chronic hepatitis B (CHB). Tim-3 expression on peripheral monocytes and frequency of Th17 cells in peripheral blood mononuclear cells (PBMCs) derived from CHB patients were detected. Read More

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http://dx.doi.org/10.1111/sji.12755DOI Listing

Identification of rheumatoid arthritis causal genes using functional genomics.

Scand J Immunol 2019 May 12;89(5):e12753. Epub 2019 Mar 12.

Arthritis Research UK Centre for Genetics and Genomics, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Over the past decade, genome-wide association studies have contributed a wealth of knowledge to our understanding of polygenic disorders such as rheumatoid arthritis. As the size of sample cohorts has improved so too have the computational and experimental methods used to robustly define variants associated with disease susceptibility. The challenge now remains to translate these findings into improved understanding of disease aetiology and patient care. Read More

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http://doi.wiley.com/10.1111/sji.12753
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May 2019
7 Reads

Downregulated Rac1 promotes apoptosis and inhibits the clearance of apoptotic cells in airway epithelial cells, which may be associated with airway hyper-responsiveness in asthma.

Scand J Immunol 2019 May 5;89(5):e12752. Epub 2019 Mar 5.

Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China.

The accumulation of airway apoptotic cells may be an important factor causing airway hyper-responsiveness (AHR). Whether the apoptotic cells can be promptly removed is related to the occurrence and course of asthma. In recent years, studies have shown that Rac1 is involved in many cellular biological activities including the formation and elimination of apoptotic cells. Read More

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http://dx.doi.org/10.1111/sji.12752DOI Listing
May 2019
2 Reads

Data-independent acquisition-based quantitative proteomic analysis reveals differences in host immune response of peripheral blood mononuclear cells to sepsis.

Scand J Immunol 2019 Apr 10;89(4):e12748. Epub 2019 Mar 10.

Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.

This study was aimed to uncover proteins that are differentially expressed in sepsis. Data-independent acquisition (DIA) was used for analysis to identify differentially expressed proteins in peripheral blood mononuclear cells (PBMCs) of patients. A total of 24 non-septic intensive care unit (ICU) patients, 11 septic shock patients and 27 patients diagnosed with sepsis were recruited for the mass spectrometry (MS) discovery. Read More

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http://dx.doi.org/10.1111/sji.12748DOI Listing
April 2019
3 Reads

Inhibition of cardiac allograft rejection in mice using interleukin-35-modified mesenchymal stem cells.

Scand J Immunol 2019 Apr 11;89(4):e12750. Epub 2019 Feb 11.

Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.

Interleukin-35 (IL-35) is a cytokine recently discovered to play a potent immunosuppressive role by intensifying the functions of regulatory T cells and inhibiting the proliferation and functions of T helper 1 and T helper 17 cells. Mesenchymal stem cells (MSCs) have recently emerged as promising candidates for cell-based immune therapy, and our previous study showed that IL-35 gene modification can effectively enhance the therapeutic effect of MSCs in vitro. In this study, we isolated adipose tissue-derived MSCs in vitro and infected them with lentiviral vectors overexpressing the IL-35 gene, thereby creating IL-35-MSCs. Read More

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http://dx.doi.org/10.1111/sji.12750DOI Listing
April 2019
5 Reads
1.882 Impact Factor

Human Gingiva-Derived Mesenchymal Stem Cells Alleviate Inflammatory Bowel Disease via IL-10 Signaling-Dependent Modulation of Immune Cells.

Scand J Immunol 2019 Jan 21:e12751. Epub 2019 Jan 21.

Department of General Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210029, China.

Current evidence indicates that inflammatory bowel disease (IBD) is caused primarily by impaired mucosal immunity, resulting in an imbalance between epithelial barrier function and tissue inflammation. Human gingiva-derived mesenchymal stem cells (GMSCs) exhibit immunomodulatory and anti-inflammatory effects in a variety of immunity- and inflammation-associated diseases. However, the role of GMSCs in treating IBD has not been elucidated. Read More

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http://dx.doi.org/10.1111/sji.12751DOI Listing
January 2019
4 Reads

Immunomodulatory role of chitosan-based nanoparticles and oligosaccharides in cyclophosphamide-treated mice.

Scand J Immunol 2019 Apr 5;89(4):e12749. Epub 2019 Mar 5.

Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Chitosan, the deacetylated form of chitin, a natural polysaccharide, is known for its various biomedical applications. The present study aimed at exploring the immunomodulatory properties of chitosan (CSNP) and gallic acid-grafted chitosan (cGANP) nanoparticles in mice model of cyclophosphamide (CPA)-induced immunosuppression. In addition, chitooligosaccharides, the hydrolysed form of chitin and chitosan, were also evaluated for its potential against immunosuppression in mice. Read More

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http://dx.doi.org/10.1111/sji.12749DOI Listing
April 2019
2 Reads

An update on immune dysregulation in obesity-related insulin resistance.

Scand J Immunol 2019 Apr 29;89(4):e12747. Epub 2019 Jan 29.

Department of Immunology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Obesity is associated with chronic low-grade inflammation of the adipose tissue (AT) that might develop into systemic inflammation, insulin resistance (IR) and an increased risk of type 2 diabetes mellitus (T2DM) in severe obese rodents and humans. In the lean state, small normal adipocytes and AT macrophages interact with each other to maintain metabolic homeostasis but during obesity, enlarged adipocytes secrete inflammatory mediators and express immune receptors to recruit immune cells and aggravate the inflammation. The better understanding of the obesity-related inflammatory milieu and the sequential events leading to IR could be helpful in designing new preventive and therapeutic strategies. Read More

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April 2019
13 Reads
2.320 Impact Factor

Two signal half-century: From negative selection of self-reactivity to positive selection of near-self-reactivity.

Scand J Immunol 2019 Apr 24;89(4):e12746. Epub 2019 Jan 24.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.

With the emergence of clonal selection ideas in the 1950s, the development of immune cell repertoires was seen to require the negative selection of self-reacting cells, with surviving cells exhibiting a broad range of specificities. Thus, confronting a universe of not-self-antigens, a potential host organism spread its resources widely. In the 1960s, the two signal hypothesis showed how this might work. Read More

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April 2019
1 Read

Cell- and tissue-specific epigenetic changes associated with chronic inflammation in insulin resistance and type 2 diabetes mellitus.

Scand J Immunol 2018 Dec 4;88(6):e12723. Epub 2018 Nov 4.

Department of Genetics, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycaemia, which can cause micro- and macrovascular complications. Chronic inflammation may be the cause and result of T2DM, and its related complications as an imbalance between pro- and anti-inflammatory cytokines can affect immune functions. Apart from genetic changes occurring within the body resulting in inflammation in T2DM, epigenetic modifications can modify gene expression in response to environmental cues such as an unhealthy diet, lack of exercise and obesity. Read More

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http://doi.wiley.com/10.1111/sji.12723
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http://dx.doi.org/10.1111/sji.12723DOI Listing
December 2018
14 Reads

Aberrant IL-35 levels in patients with primary Sjogren's syndrome.

Scand J Immunol 2018 Nov;88(5):e12718

Department of Clinical Experiment, Changhai Hospital, Second Military Medical University, Shanghai, China.

Objective: IL-35 is a newly discovered immunoregulatory cytokine that possesses the ability to inhibit CD4 + effector T cells and alleviate autoimmune diseases. The objective of this study was to investigate IL-35 levels in patients with primary Sjogren's syndrome (pSS) and explore the roles of IL-35 in the pathogenesis of pSS.

Methods: Thirty-four hospitalized patients with pSS were recruited, and 34 volunteers were enrolled as healthy controls. Read More

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http://dx.doi.org/10.1111/sji.12718DOI Listing
November 2018
15 Reads

Recombinant pyrin domain protein attenuates allergic inflammation by suppressing NF-κB pathway in asthmatic mice.

Scand J Immunol 2019 Jan 20;89(1):e12720. Epub 2018 Nov 20.

Department of Anatomy and Histology and Embryology, Yanbian University Medical College, YanJi, Jilin, China.

Pyrin domain (PYD), a subclass of protein motif known as the death fold, is frequently involved in inflammation and immune responses. PYD modulates nuclear factor-kappa B (NF-κB) signalling pathway upon various stimuli. Herein, a novel recombinant pyrin domain protein (RPYD) was generated. Read More

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http://dx.doi.org/10.1111/sji.12720DOI Listing
January 2019
3 Reads

Towards improved control of inflammatory bowel disease.

Scand J Immunol 2019 Mar;89(3):e12745

Department of Medicine, Center for Bioelectronic Medicine, Bioclinicum, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden.

Inflammatory bowel disease (IBD) is characterized by activation of both the innate and adaptive immune system in genetically susceptible individuals, resulting in chronic intestinal inflammation. The triggers that initiate and perpetuate this continuous inflammation are the subject of much speculation and research, although the central role of the intestinal microbiota is recognized, and is even a target for treatment in some circumstances. The mainstay of modern IBD treatment is suppression of the immune response towards as yet unspecified antigens, and conventional therapy includes corticosteroids, 5-aminosalicylic acid (5-ASA), thiopurines and methotrexate. Read More

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March 2019
1 Read

Treating osteosarcoma with CAR T cells.

Scand J Immunol 2019 Mar 15;89(3):e12741. Epub 2019 Jan 15.

Laboratory of Translational Research & Immunomonitoring, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway.

Novel therapies to treat patients with solid cancers that have developed resistance to chemotherapy represent unmet needs of considerable dimensions. In the present review, we will address the attempts to develop chimeric antigen receptor (CAR) targeted immunotherapy against osteosarcoma (OS). This aggressive cancer displays its peak incidence in children and young adults. Read More

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http://dx.doi.org/10.1111/sji.12741DOI Listing
March 2019
1 Read

Dichotomy of Notch signalling in regulating tumour immune surveillance.

Scand J Immunol 2019 Mar 15;89(3):e12744. Epub 2019 Jan 15.

Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.

Notch signalling is an evolutionarily conserved multifaceted pathway that controls diverse cellular processes. Its role in regulating development and tissue homeostasis is well established. Aberrant activation of the Notch pathway has been implicated in the initiation and progression of many types of cancers. Read More

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http://dx.doi.org/10.1111/sji.12744DOI Listing
March 2019
5 Reads

Anti-psoriatic effect of myeloid-derived suppressor cells on imiquimod-induced skin inflammation in mice.

Scand J Immunol 2019 Mar 15;89(3):e12742. Epub 2019 Jan 15.

Pharmicell Co., Ltd. 484, Seongnam, Gyeonggi-do, Korea.

Myeloid-derived suppressor cells (MDSCs) play an important role in controlling the immune response against cancer and in suppression of autoimmunity and allergic inflammation. However, the beneficial effects of MDSCs on the experimental mouse model of psoriasis have not been reported. Therefore, we investigated the anti-psoriatic effect of MDSCs on IMQ-induced skin inflammation in mice and explored the mechanisms involved. Read More

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http://dx.doi.org/10.1111/sji.12742DOI Listing
March 2019
4 Reads

Immunotherapeutic effects of recombinant adenovirus encoding interleukin 12 in experimental pulmonary tuberculosis.

Scand J Immunol 2019 Mar 24;89(3):e12743. Epub 2019 Jan 24.

Sección de Patología Experimental, Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, México.

High dose of Mycobacterium tuberculosis (Mtb) strain H37Rv administered by intratracheal injection in BALB/c mice induce progressive tuberculosis (TB). In this model, during the first month there is a temporal control of bacillary growth, in coexistence with macrophage activation, granuloma formation and Th-1 response. Then, bacterial proliferation recommences, accompanied by progressive pneumonia and decreasing expression of protective cytokines (IFN-γ and TNF-α). Read More

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http://dx.doi.org/10.1111/sji.12743DOI Listing
March 2019
2 Reads

Association of group-specific component exon 11 polymorphisms with bronchial asthma in children and adolescents.

Scand J Immunol 2019 Mar 23;89(3):e12740. Epub 2019 Jan 23.

Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Several studies have investigated the association of Group-specific Component (GC) gene, also known as vitamin D-binding protein (VDBP), and various respiratory disorder susceptibility with conflicting results. In this sense, we aimed to investigate whether rs7041 and rs4588 variants confer susceptibility to bronchial asthma in a sample of an Egyptian population and to elucidate by in silico analysis the structural and functional impact of these variants. Group-specific Component polymorphisms rs7041 and rs4588 were genotyped in 192 Egyptian children and adolescents (96 with asthma and 96 healthy controls) by TaqMan single nucleotide polymorphism genotyping assay. Read More

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http://dx.doi.org/10.1111/sji.12740DOI Listing
March 2019
4 Reads
1.882 Impact Factor

Emerging role of stem cell memory-like T cell in immune thrombocytopenia.

Scand J Immunol 2019 Mar 4;89(3):e12739. Epub 2019 Jan 4.

Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by autoantibody-mediated platelet destruction. Multiple factors have been implicated in ITP pathogenesis, including T-lymphocyte dysfunctions. Increasing studies have indicated that stem cell memory-like T cell (TSCM) plays an important role in the development of multiple autoimmune diseases. Read More

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http://doi.wiley.com/10.1111/sji.12739
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http://dx.doi.org/10.1111/sji.12739DOI Listing
March 2019
30 Reads
1.882 Impact Factor

Monoclonal antibody against human Tim-3 enhances antiviral immune response.

Scand J Immunol 2019 Feb 4;89(2):e12738. Epub 2019 Jan 4.

Institute of Beijing Brain Sciences, Beijing, China.

T cell immunoglobulin and mucin domain protein 3 (Tim-3) is an immune checkpoint inhibitor in T cells and innate immune cells. The deregulated upregulation of Tim-3 is related to immune exhaustion in tumour and viral infection. To overcome Tim-3-mediated immune tolerance, we developed a novel monoclonal antibody against human Tim-3 (L3G) and investigated its roles in inhibiting Tim-3 signalling and overcoming immune tolerance in T cells and monocytes/macrophages. Read More

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http://dx.doi.org/10.1111/sji.12738DOI Listing
February 2019
5 Reads
1.882 Impact Factor

Chronic granulamatous disease: Two decades of experience from a paediatric immunology unit in a country with high rate of consangineous marriages.

Scand J Immunol 2019 Feb 23;89(2):e12737. Epub 2019 Jan 23.

Department of Pediatric Immunology, Ege University Faculty of Medicine, Izmir, Turkey.

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by susceptibility to bacterial and fungal infections resulting from the inadequacy of phagocytic leucocytes to produce reactive oxygen radicals. CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by mutations in the CYBB (OMIM #300481) gene encoding the gp91(phox) protein, and an autosomal recessive (AR-CGD) form caused by mutations in the CYBA (OMIM #608508), NCF1 (OMIM #608512), NCF2 (OMIM #608515) and NCF4 (OMIM #601488) genes encoding p22(phox), p47(phox), p67(phox) and p40(phox), respectively. The genetic mutation of one of the cytosolic p47phox/p67phox proteins and membrane-bound gp91phox/p22phox proteins, which constitutes the NADPH oxidase enzyme complex, causes the disease. Read More

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http://dx.doi.org/10.1111/sji.12737DOI Listing
February 2019
12 Reads

Antigen-specific CD8 T cells in cell cycle circulate in the blood after vaccination.

Scand J Immunol 2019 Feb 15;89(2):e12735. Epub 2019 Jan 15.

Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy.

Although clonal expansion is a hallmark of adaptive immunity, the location(s) where antigen-responding T cells enter cell cycle and complete it have been poorly explored. This lack of knowledge stems partially from the limited experimental approaches available. By using Ki67 plus DNA staining and a novel strategy for flow cytometry analysis, we distinguished antigen-specific CD8 T cells in G , in G and in S-G /M phases of cell cycle after intramuscular vaccination of BALB/c mice with antigen-expressing viral vectors. Read More

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http://doi.wiley.com/10.1111/sji.12735
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February 2019
19 Reads

Targeting cytokines secreted by CD4 CD25 CD127  regulatory T cells inhibits ovarian cancer progression.

Authors:
Xing Ke Lisong Shen

Scand J Immunol 2019 Feb 27;89(2):e12736. Epub 2018 Dec 27.

Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Epithelial ovarian cancer (EOC) is one of the major malignant cancers with high rates of early metastasis in which regulatory T cells (Tregs) play an important role. Tregs suppress immune responses and promote the development of tumours in patients with EOC. However, the underlying mechanisms remain unclear. Read More

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February 2019
8 Reads

Role of arginine deiminase in thymic atrophy during experimental Streptococcus pyogenes infection.

Scand J Immunol 2019 Feb 4;89(2):e12734. Epub 2019 Jan 4.

Federal State Budgetary Scientific Institution, Institute of Experimental Medicine, St. Petersburg, Russia.

Expression of gene of arginine deiminase (AD) allows adaptation of Streptococcus pyogenes to adverse environmental conditions. AD activity can lead to L-arginine deficiency in the host cells' microenvironment. Bioavailability of L-arginine is an important factor regulating the functions of the immune cells in mammals. Read More

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February 2019
16 Reads

Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis.

Scand J Immunol 2019 Jan 9;89(1):e12732. Epub 2018 Dec 9.

Division of Rheumatology, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden.

We aimed to evaluate in vivo effects of abatacept on phenotypes of T and B cells in the circulation of myositis patients in a sub-study of the ARTEMIS trial. Twelve patients with paired frozen PBMCs before and after 6-month abatacept treatment were included in this sub-study where mass cytometry (CyTOF) was chosen as a technology to be tested for its utility in a real-life clinical immune monitoring setting. Using CyTOF, the peripheral T cell phenotypes demonstrated considerable variation over time and between individuals precluding the identification of treatment-specific changes. Read More

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January 2019
20 Reads
1.882 Impact Factor

T11TS immunotherapy augments microglial and lymphocyte protective immune responses against Cryptococcus neoformans in the brain.

Scand J Immunol 2019 Feb 27;89(2):e12733. Epub 2018 Dec 27.

Department of Laboratory Medicine, School of Tropical Medicine, Kolkata, India.

Cryptococcus neoformans, the encapsulated yeast acquired through inhalation, remains localized in lungs, but harbours the CNS in immunocompromised individuals. Several treatment regimes have failed combating this disease totally, but long-term usage of drugs leads to organ damage. As T11-target structure (T11TS) has documented profound immune potentiation, we aimed to investigate the role of microglia, pivotal immune cells of brain in ameliorating cryptococcosis, with T11TS immunotherapy. Read More

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February 2019
16 Reads
1.882 Impact Factor

CCR2 upregulated on peripheral T cells in osteoarthritis but not in bone marrow.

Scand J Immunol 2018 Dec 28;88(6):e12722. Epub 2018 Oct 28.

Department of Medicine, Immunology and Allergy Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Osteoarthritis (OA) is a condition affecting millions of patients around the world, causing pain and disability and often resulting in joint replacement surgery. The aetiology of OA has long been attributed to mechanical wear mainly due to the increased prevalence of OA in load bearing joints among older patients. However, recent studies reveal a complex molecular disease causality in which inflammation, nutritional deficit and angiogenesis lead to the destruction of the joint structure. Read More

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http://doi.wiley.com/10.1111/sji.12722
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December 2018
33 Reads

Maternal immunization downregulates offspring TCD4 regulatory cells (Tregs) thymic maturation without implications for allergy inhibition.

Scand J Immunol 2018 Dec 28;88(6):e12721. Epub 2018 Oct 28.

Division of Dermatology, Laboratory of Medical Investigation LIM 56, Medical School, University of Sao Paulo, Sao Paulo, Brazil.

The regulation of offspring allergy development mediated by maternal immunization was evidenced by several groups, and this mechanism seems to involve the induction of regulatory T cells (Tregs) on offspring. Here, we aimed to evaluate whether the effect of maternal immunization on offspring Tregs occurs as a result of peripheral or central modulation. Briefly, C57BL/6 female mice were immunized with OVA in Alum or Alum alone and boosted with OVA in saline or saline only after 10 and 20 days. Read More

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http://doi.wiley.com/10.1111/sji.12721
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December 2018
13 Reads

Redox imbalance and IL-17 responses in memory CD4 T cells from patients with psoriasis.

Scand J Immunol 2019 Jan 19;89(1):e12730. Epub 2018 Dec 19.

Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

All stages of the inflammatory process involved in T cell-mediated chronic skin disorders like psoriasis are affected by redox imbalance. On the other hand, Th17 cells have a critical role in the pathogenesis of psoriasis. In this study, we evaluated redox status in memory CD4 + T cells and plasma of patients with psoriasis and its correlation with IL-17 response. Read More

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http://doi.wiley.com/10.1111/sji.12730
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January 2019
9 Reads
1.882 Impact Factor

LprG and PE_PGRS33 Mycobacterium tuberculosis virulence factors induce differential mitochondrial dynamics in macrophages.

Scand J Immunol 2019 Jan 30;89(1):e12728. Epub 2018 Nov 30.

Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.

The interaction of a pathogen with its host cell takes place at different levels, including the bioenergetics adaptation of both the pathogen and the host cell in the course of an infection. In this regard, Mycobacterium tuberculosis infection of macrophages induces mitochondrial membrane potential (Δψm) changes and cytochrome c release, depending on the bacteria strain's virulence, and the mitochondrial dynamics is modified by pathogens, such as Listeria monocytogenes. Here, we investigated whether two M. Read More

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January 2019
14 Reads

The DosR antigen Rv1737c from Mycobacterium tuberculosis confers inflammation regulation in tuberculosis infection.

Scand J Immunol 2019 Jan 23;89(1):e12729. Epub 2018 Nov 23.

School of Public Health, Lanzhou University, Lanzhou, China.

There is an urgent need to identify the potential risk factors for activating latent Mycobacterium tuberculosis infection. In this study, we evaluated the immune function of Rv1737c, which is a latency-associated antigen of dormancy survival regulator (DosR) of M. tuberculosis in a mouse model. Read More

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January 2019
9 Reads

The roles of SOCS3 and STAT3 in bacterial infection and inflammatory diseases.

Scand J Immunol 2018 Dec;88(6):e12727

Translational Neuroscience & Neural Regeneration and Repair Institute/Institute of Cell Therapy, The People's Hospital of China Three Gorges University, Yichang, China.

The suppressor of cytokine signalling-3 (SOCS3) is well known as a feedback inhibitor of the Janus kinases-signal transducer and activator of transcription 3 (JAK/STAT3) signalling pathway, which mediates the signal transduction of many cytokines, growth factors and hormones during many cellular processes. The critical role of SOCS3 is manifested by its binding to both the JAK kinase and the cytokine receptor, which can result in the inhibition of STAT3 phosphorylation. STAT3 triggers variety of genes expression in response to cytokine (IL-6 family, IL-10) and growth factor stimulation and thus plays a critical role in many cellular biological processes involved in anti/pro-inflammatory responses, cell growth and cell death. Read More

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December 2018
15 Reads

The real "danger" lies in the failure to confront fundamentals.

Authors:
Melvin Cohn

Scand J Immunol 2018 Dec 4;88(6):e12726. Epub 2018 Nov 4.

Conceptual Immunology Group, The Salk Institute, La Jolla, California.

Can we formulate a framework that would provide an agreed upon basis for discussions of immune behaviour? An attempt to do this is, in the end, the main goal of this essay. If you tell a physicist that you have invented a perpetual motion machine, he would not spend any time trying to reveal the flaw. Rather, he would shrug you off because in his framework, such a machine is an impossibility. Read More

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December 2018
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