6,990 results match your criteria Scandinavian Journal of Immunology[Journal]


Interferon-γ facilitated adjuvant-induced arthritis at early stage.

Scand J Immunol 2019 Feb 9:e12757. Epub 2019 Feb 9.

Department of Rheumatology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, People's Republic of China.

Background And Aim: Interferon-γ (IFN-γ) is a versatile cytokine which broadly involves in the inflammatory diseases, mediating both immune activation and tolerance. Here, we aimed to investigate the role of IFN-γ in the initiation of adjuvant-induced arthritis (AIA).

Methods And Results: In an AIA mice model, increasing IFN-γ mRNA was observed at day 3 and peaked on day 7. Read More

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http://dx.doi.org/10.1111/sji.12757DOI Listing
February 2019

The role of immunity in the pathogenesis and development of preeclampsia.

Authors:
Hui-Qing Lu Rong Hu

Scand J Immunol 2019 Feb 9:e12756. Epub 2019 Feb 9.

Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China.

Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality, however, the aetiology of preeclampsia still remains unclear. It has been widely accepted that the disease results from insufficient spiral artery remodelling, leading to placental ischaemia and the release of a variety of factors. In recent decades, a large number of studies have observed an abnormal immune response in preeclamptic women and studies of both patients and animal models have shown alterations in the function or the number of immune agents. Read More

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February 2019

Kinetics of Helios(+) and Helios(-) T regulatory cell subsets in the circulation of healthy pregnant women.

Scand J Immunol 2019 Feb 7:e12754. Epub 2019 Feb 7.

Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.

Regulatory T cells (Tregs) play a critical role in the maintenance of a pregnancy. While the kinetics of the number of peripheral blood Tregs has been satisfactorily described in mouse models, analysis of these cell populations in human pregnancy is complicated by high variability in the quantity of Tregs and inconsistencies in the markers used for detecting different types of Treg. In light of this, we set out to investigate the kinetics of various types of Treg, including CD45RA, GARP and PD-1(+) Tregs, in the peripheral blood of pregnant women in the first, second and third trimester, and at the time of delivery. Read More

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February 2019

Tim-3 regulates inflammatory cytokine expression and Th17 cell response induced by monocytes from patients with chronic hepatitis B.

Scand J Immunol 2019 Feb 7:e12755. Epub 2019 Feb 7.

Department of Infectious Disease, The Affiliated Hospital of Xuzhou Medical University, 99 West Huai-hai Rd, Xuzhou, China, 221002.

Tim-3 is expressed on monocytes/macrophages, and is involved in the regulation of inflammatory responses. The aim of this study was to determine the effect of Tim-3 on inflammatory response triggered by peripheral monocytes from patients with chronic hepatitis B (CHB). Tim-3 expression on peripheral monocytes and frequency of Th17 cells in peripheral blood mononuclear cells (PBMCs) derived from CHB patients were detected. Read More

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February 2019

Identification of rheumatoid arthritis causal genes using functional genomics.

Scand J Immunol 2019 Feb 1:e12753. Epub 2019 Feb 1.

Arthritis Research, UK Centre for Genetics and Genomics., Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester.

Over the past decade genome-wide association studies have contributed a wealth of knowledge to our understanding of polygenic disorders such as rheumatoid arthritis. As the size of sample cohorts has improved so too have the computational and experimental methods used to robustly define variants associated with disease susceptibility. The challenge now remains to translate these finding into improved understanding of disease aetiology and patient care. Read More

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February 2019
3 Reads

Down-regulated Rac1 promotes apoptosis and inhibits the clearance of apoptotic cells in airway epithelial cells, which may be associated with airway hyper-responsiveness in asthma.

Scand J Immunol 2019 Jan 25:e12752. Epub 2019 Jan 25.

Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 212013, China.

The accumulation of airway apoptotic cells may be an important factor causing airway hyper-responsiveness. Whether the apoptotic cells can be prompt removed is related to the occurrence and course of asthma. In recent years, studies have shown that Rac1 is involved in many cellular biological activities including the formation and elimination of apoptotic cells. Read More

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January 2019
1 Read

Data-Independent Acquisition-Based Quantitative Proteomic Analysis Reveals Differences in Host Immune Response of Peripheral Blood Mononuclear Cells to Sepsis.

Scand J Immunol 2019 Jan 22:e12748. Epub 2019 Jan 22.

Department of Trauma-Emergency&Critical Care medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 290240, China.

This study was aimed to uncover proteins that are differentially expressed in sepsis. Data Independent Acquisition (DIA) was used for analysis to identify differentially expressed proteins in peripheral blood mononuclear cells (PBMCs) of patients. A total of 24 non-septic Intensive Care Unit (ICU) patients, 11 septic shock patients and 27 patients diagnosed with sepsis were recruited for the Mass Spectrometry (MS) discovery. Read More

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January 2019
2 Reads

Inhibition of cardiac allograft rejection in mice using interleukin-35-modified mesenchymal stem cells.

Scand J Immunol 2019 Jan 21:e12750. Epub 2019 Jan 21.

Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.

Interleukin-35 (IL-35) is a cytokine recently discovered to play a potent immunosuppressive role by intensifying the functions of regulatory T cells and inhibiting the proliferation and functions of T helper 1 and T helper 17 cells. Mesenchymal stem cells (MSCs) have recently emerged as promising candidates for cell-based immune therapy, and our previous study showed that IL-35 gene modification can effectively enhance the therapeutic effect of MSCs in vitro. In this study, we isolated adipose tissue-derived MSCs in vitro and infected them with lentiviral vectors overexpressing the IL-35 gene, thereby creating IL-35-MSCs. Read More

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http://dx.doi.org/10.1111/sji.12750DOI Listing
January 2019
3 Reads
1.882 Impact Factor

Human Gingiva-Derived Mesenchymal Stem Cells Alleviate Inflammatory Bowel Disease via IL-10 Signaling-Dependent Modulation of Immune Cells.

Scand J Immunol 2019 Jan 21:e12751. Epub 2019 Jan 21.

Department of General Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210029, China.

Current evidence indicates that inflammatory bowel disease (IBD) is caused primarily by impaired mucosal immunity, resulting in an imbalance between epithelial barrier function and tissue inflammation. Human gingiva-derived mesenchymal stem cells (GMSCs) exhibit immunomodulatory and anti-inflammatory effects in a variety of immunity- and inflammation-associated diseases. However, the role of GMSCs in treating IBD has not been elucidated. Read More

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January 2019
4 Reads

Immunomodulatory role of chitosan-based nanoparticles and oligosaccharides in cyclophosphamide treated mice.

Scand J Immunol 2019 Jan 21:e12749. Epub 2019 Jan 21.

Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India.

Chitosan, the deacetylated form of chitin, a natural polysaccharide, is known for its various biomedical applications. The present study aimed at exploring the immunomodulatory properties of chitosan (CSNP) and gallic acid grafted chitosan (cGANP) nanoparticles in mice model of cyclophosphamide (CPA)-induced immunosuppression. In addition, chitooligosaccharides, the hydrolysed form of chitin and chitosan were also evaluated for its potential against immunosuppression in mice. Read More

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http://dx.doi.org/10.1111/sji.12749DOI Listing
January 2019
2 Reads

An update on immune dysregulation in obesity-related insulin resistance.

Scand J Immunol 2018 Dec 28:e12747. Epub 2018 Dec 28.

Department of Immunology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Obesity is associated with chronic low-grade inflammation of the adipose tissue (AT) that might develop into systemic inflammation, insulin resistance (IR) and an increased risk of type 2 diabetes mellitus (T2DM) in severe obese rodents and humans. In the lean state, small normal adipocytes and AT macrophages interact with each other to maintain metabolic homeostasis but during obesity, enlarged adipocytes secrete inflammatory mediators and express immune receptors to recruit immune cells and aggravate the inflammation. The better understanding of the obesity-related inflammatory milieu and the sequential events leading to IR could be helpful in designing new preventive and therapeutic strategies. Read More

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December 2018
8 Reads
2.320 Impact Factor

Two signal half-century: From negative selection of self-reactivity to positive selection of near-self-reactivity.

Scand J Immunol 2018 Dec 28:e12746. Epub 2018 Dec 28.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.

With the emergence of clonal selection ideas in the 1950s, the development of immune cell repertoires was seen to require the negative selection of self-reacting cells, with surviving cells exhibiting a broad range of specificities. Thus, confronting a universe of not-self-antigens, a potential host organism spread its resources widely. In the 1960s, the two signal hypothesis showed how this might work. Read More

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December 2018
1 Read

Cell- and tissue-specific epigenetic changes associated with chronic inflammation in insulin resistance and type 2 diabetes mellitus.

Scand J Immunol 2018 Dec 4;88(6):e12723. Epub 2018 Nov 4.

Department of Genetics, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycaemia, which can cause micro- and macrovascular complications. Chronic inflammation may be the cause and result of T2DM, and its related complications as an imbalance between pro- and anti-inflammatory cytokines can affect immune functions. Apart from genetic changes occurring within the body resulting in inflammation in T2DM, epigenetic modifications can modify gene expression in response to environmental cues such as an unhealthy diet, lack of exercise and obesity. Read More

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http://doi.wiley.com/10.1111/sji.12723
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December 2018
13 Reads

Aberrant IL-35 levels in patients with primary Sjogren's syndrome.

Scand J Immunol 2018 Nov;88(5):e12718

Department of Clinical Experiment, Changhai Hospital, Second Military Medical University, Shanghai, China.

Objective: IL-35 is a newly discovered immunoregulatory cytokine that possesses the ability to inhibit CD4 + effector T cells and alleviate autoimmune diseases. The objective of this study was to investigate IL-35 levels in patients with primary Sjogren's syndrome (pSS) and explore the roles of IL-35 in the pathogenesis of pSS.

Methods: Thirty-four hospitalized patients with pSS were recruited, and 34 volunteers were enrolled as healthy controls. Read More

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http://dx.doi.org/10.1111/sji.12718DOI Listing
November 2018
11 Reads

Recombinant pyrin domain protein attenuates allergic inflammation by suppressing NF-κB pathway in asthmatic mice.

Scand J Immunol 2019 Jan 20;89(1):e12720. Epub 2018 Nov 20.

Department of Anatomy and Histology and Embryology, Yanbian University Medical College, YanJi, Jilin, China.

Pyrin domain (PYD), a subclass of protein motif known as the death fold, is frequently involved in inflammation and immune responses. PYD modulates nuclear factor-kappa B (NF-κB) signalling pathway upon various stimuli. Herein, a novel recombinant pyrin domain protein (RPYD) was generated. Read More

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http://dx.doi.org/10.1111/sji.12720DOI Listing
January 2019
3 Reads

Toward Improved Control of Inflammatory Bowel Disease.

Scand J Immunol 2018 Dec 23:e12745. Epub 2018 Dec 23.

Center for Bioelectronic Medicine, Department of Medicine, Center for Molecular Medicine, Solna, Karolinska Institutet, Karolinska University HospitalStockholm, Sweden.

Inflammatory bowel disease (IBD), is characterized by activation of both the innate and adaptive immune system in genetically susceptible individuals, resulting in chronic intestinal inflammation. The triggers that initiate and perpetuate this continuous inflammation are the subject of much speculation and research, although the central role of the intestinal microbiota is recognized and is even a target for treatment in some circumstances. The mainstay of modern IBD-treatment is suppression of the immune response towards as yet unspecified antigens, and conventional therapy includes corticosteroids, 5-aminosalicylic acid (5-ASA), thiopurines and methotrexate. Read More

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December 2018
1 Read

Treating osteosarcoma with CAR T cells.

Scand J Immunol 2018 Dec 14:e12741. Epub 2018 Dec 14.

Laboratory of Translational Research & Immunomonitoring, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway.

Novel therapies to treat patients with solid cancers that have developed resistance to chemotherapy represent unmet needs of considerable dimensions. In the present review, we will address the attempts to develop chimeric antigen receptor (CAR) targeted immunotherapy against osteosarcoma (OS). This aggressive cancer displays its peak incidence in children and young adults. Read More

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December 2018
1 Read

Dichotomy of Notch signalling in regulating tumour immune surveillance.

Scand J Immunol 2018 Dec 13:e12744. Epub 2018 Dec 13.

Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.

Notch signalling is an evolutionarily conserved multifaceted pathway that controls diverse cellular processes. Its role in regulating development and tissue homeostasis is well established. Aberrant activation of the Notch pathway has been implicated in the initiation and progression of many types of cancers. Read More

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http://dx.doi.org/10.1111/sji.12744DOI Listing
December 2018
1 Read

Anti-psoriatic effect of myeloid-derived suppressor cells on imiquimod-induced skin inflammation in mice.

Scand J Immunol 2018 Dec 13:e12742. Epub 2018 Dec 13.

Pharmicell Co., Ltd. 484, Seongnam, Gyeonggi-do, Korea.

Myeloid-derived suppressor cells (MDSCs) play an important role in controlling the immune response against cancer and in suppression of autoimmunity and allergic inflammation. However, the beneficial effects of MDSCs on the experimental mouse model of psoriasis have not been reported. Therefore, we investigated the anti-psoriatic effect of MDSCs on IMQ-induced skin inflammation in mice and explored the mechanisms involved. Read More

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http://dx.doi.org/10.1111/sji.12742DOI Listing
December 2018
3 Reads

Immunotherapeutic effects of recombinant adenovirus encoding interleukin 12 in experimental pulmonary tuberculosis.

Scand J Immunol 2018 Dec 13:e12743. Epub 2018 Dec 13.

Sección de Patología Experimental, Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, México.

High dose of Mycobacterium tuberculosis (Mtb) strain H37Rv administered by intratracheal injection in BALB/c mice induce progressive tuberculosis (TB). In this model, during the first month there is a temporal control of bacillary growth, in coexistence with macrophage activation, granuloma formation and Th-1 response. Then, bacterial proliferation recommences, accompanied by progressive pneumonia and decreasing expression of protective cytokines (IFN-γ and TNF-α). Read More

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http://dx.doi.org/10.1111/sji.12743DOI Listing
December 2018
2 Reads

Association of group-specific component exon 11 polymorphisms with bronchial asthma in children and adolescents.

Scand J Immunol 2018 Dec 12:e12740. Epub 2018 Dec 12.

Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Several studies have investigated the association of Group-specific Component (GC) gene, also known as vitamin D-binding protein (VDBP), and various respiratory disorder susceptibility with conflicting results. In this sense, we aimed to investigate whether rs7041 and rs4588 variants confer susceptibility to bronchial asthma in a sample of an Egyptian population and to elucidate by in silico analysis the structural and functional impact of these variants. Group-specific Component polymorphisms rs7041 and rs4588 were genotyped in 192 Egyptian children and adolescents (96 with asthma and 96 healthy controls) by TaqMan single nucleotide polymorphism genotyping assay. Read More

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http://dx.doi.org/10.1111/sji.12740DOI Listing
December 2018
3 Reads
1.882 Impact Factor

Emerging role of stem cell memory-like T cell in immune thrombocytopenia.

Scand J Immunol 2018 Dec 1:e12739. Epub 2018 Dec 1.

Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by autoantibody-mediated platelet destruction. Multiple factors have been implicated in ITP pathogenesis, including T-lymphocyte dysfunctions. Increasing studies have indicated that stem cell memory-like T cell (TSCM) plays an important role in the development of multiple autoimmune diseases. Read More

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http://doi.wiley.com/10.1111/sji.12739
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December 2018
19 Reads
1.882 Impact Factor

Monoclonal antibody against human Tim-3 enhances antiviral immune response.

Scand J Immunol 2019 Feb 4;89(2):e12738. Epub 2019 Jan 4.

Institute of Beijing Brain Sciences, Beijing, China.

T cell immunoglobulin and mucin domain protein 3 (Tim-3) is an immune checkpoint inhibitor in T cells and innate immune cells. The deregulated upregulation of Tim-3 is related to immune exhaustion in tumour and viral infection. To overcome Tim-3-mediated immune tolerance, we developed a novel monoclonal antibody against human Tim-3 (L3G) and investigated its roles in inhibiting Tim-3 signalling and overcoming immune tolerance in T cells and monocytes/macrophages. Read More

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http://dx.doi.org/10.1111/sji.12738DOI Listing
February 2019
5 Reads
1.882 Impact Factor

Chronic granulamatous disease: Two decades of experience from a paediatric immunology unit in a country with high rate of consangineous marriages.

Scand J Immunol 2019 Feb 23;89(2):e12737. Epub 2019 Jan 23.

Department of Pediatric Immunology, Ege University Faculty of Medicine, Izmir, Turkey.

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by susceptibility to bacterial and fungal infections resulting from the inadequacy of phagocytic leucocytes to produce reactive oxygen radicals. CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by mutations in the CYBB (OMIM #300481) gene encoding the gp91(phox) protein, and an autosomal recessive (AR-CGD) form caused by mutations in the CYBA (OMIM #608508), NCF1 (OMIM #608512), NCF2 (OMIM #608515) and NCF4 (OMIM #601488) genes encoding p22(phox), p47(phox), p67(phox) and p40(phox), respectively. The genetic mutation of one of the cytosolic p47phox/p67phox proteins and membrane-bound gp91phox/p22phox proteins, which constitutes the NADPH oxidase enzyme complex, causes the disease. Read More

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http://dx.doi.org/10.1111/sji.12737DOI Listing
February 2019
9 Reads

Antigen-specific CD8 T cells in cell cycle circulate in the blood after vaccination.

Scand J Immunol 2019 Feb 15;89(2):e12735. Epub 2019 Jan 15.

Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy.

Although clonal expansion is a hallmark of adaptive immunity, the location(s) where antigen-responding T cells enter cell cycle and complete it have been poorly explored. This lack of knowledge stems partially from the limited experimental approaches available. By using Ki67 plus DNA staining and a novel strategy for flow cytometry analysis, we distinguished antigen-specific CD8 T cells in G , in G and in S-G /M phases of cell cycle after intramuscular vaccination of BALB/c mice with antigen-expressing viral vectors. Read More

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http://doi.wiley.com/10.1111/sji.12735
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February 2019
14 Reads

Targeting cytokines secreted by CD4 CD25 CD127  regulatory T cells inhibits ovarian cancer progression.

Authors:
Xing Ke Lisong Shen

Scand J Immunol 2019 Feb 27;89(2):e12736. Epub 2018 Dec 27.

Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Epithelial ovarian cancer (EOC) is one of the major malignant cancers with high rates of early metastasis in which regulatory T cells (Tregs) play an important role. Tregs suppress immune responses and promote the development of tumours in patients with EOC. However, the underlying mechanisms remain unclear. Read More

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February 2019
7 Reads

Role of arginine deiminase in thymic atrophy during experimental Streptococcus pyogenes infection.

Scand J Immunol 2019 Feb 4;89(2):e12734. Epub 2019 Jan 4.

Federal State Budgetary Scientific Institution, Institute of Experimental Medicine, St. Petersburg, Russia.

Expression of gene of arginine deiminase (AD) allows adaptation of Streptococcus pyogenes to adverse environmental conditions. AD activity can lead to L-arginine deficiency in the host cells' microenvironment. Bioavailability of L-arginine is an important factor regulating the functions of the immune cells in mammals. Read More

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http://dx.doi.org/10.1111/sji.12734DOI Listing
February 2019
13 Reads

Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis.

Scand J Immunol 2019 Jan 9;89(1):e12732. Epub 2018 Dec 9.

Division of Rheumatology, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden.

We aimed to evaluate in vivo effects of abatacept on phenotypes of T and B cells in the circulation of myositis patients in a sub-study of the ARTEMIS trial. Twelve patients with paired frozen PBMCs before and after 6-month abatacept treatment were included in this sub-study where mass cytometry (CyTOF) was chosen as a technology to be tested for its utility in a real-life clinical immune monitoring setting. Using CyTOF, the peripheral T cell phenotypes demonstrated considerable variation over time and between individuals precluding the identification of treatment-specific changes. Read More

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http://doi.wiley.com/10.1111/sji.12732
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January 2019
18 Reads
1.882 Impact Factor

T11TS immunotherapy augments microglial and lymphocyte protective immune responses against Cryptococcus neoformans in the brain.

Scand J Immunol 2019 Feb 27;89(2):e12733. Epub 2018 Dec 27.

Department of Laboratory Medicine, School of Tropical Medicine, Kolkata, India.

Cryptococcus neoformans, the encapsulated yeast acquired through inhalation, remains localized in lungs, but harbours the CNS in immunocompromised individuals. Several treatment regimes have failed combating this disease totally, but long-term usage of drugs leads to organ damage. As T11-target structure (T11TS) has documented profound immune potentiation, we aimed to investigate the role of microglia, pivotal immune cells of brain in ameliorating cryptococcosis, with T11TS immunotherapy. Read More

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http://dx.doi.org/10.1111/sji.12733DOI Listing
February 2019
8 Reads
1.882 Impact Factor

CCR2 upregulated on peripheral T cells in osteoarthritis but not in bone marrow.

Scand J Immunol 2018 Dec 28;88(6):e12722. Epub 2018 Oct 28.

Department of Medicine, Immunology and Allergy Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Osteoarthritis (OA) is a condition affecting millions of patients around the world, causing pain and disability and often resulting in joint replacement surgery. The aetiology of OA has long been attributed to mechanical wear mainly due to the increased prevalence of OA in load bearing joints among older patients. However, recent studies reveal a complex molecular disease causality in which inflammation, nutritional deficit and angiogenesis lead to the destruction of the joint structure. Read More

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http://doi.wiley.com/10.1111/sji.12722
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http://dx.doi.org/10.1111/sji.12722DOI Listing
December 2018
25 Reads

Maternal immunization downregulates offspring TCD4 regulatory cells (Tregs) thymic maturation without implications for allergy inhibition.

Scand J Immunol 2018 Dec 28;88(6):e12721. Epub 2018 Oct 28.

Division of Dermatology, Laboratory of Medical Investigation LIM 56, Medical School, University of Sao Paulo, Sao Paulo, Brazil.

The regulation of offspring allergy development mediated by maternal immunization was evidenced by several groups, and this mechanism seems to involve the induction of regulatory T cells (Tregs) on offspring. Here, we aimed to evaluate whether the effect of maternal immunization on offspring Tregs occurs as a result of peripheral or central modulation. Briefly, C57BL/6 female mice were immunized with OVA in Alum or Alum alone and boosted with OVA in saline or saline only after 10 and 20 days. Read More

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http://doi.wiley.com/10.1111/sji.12721
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December 2018
11 Reads

Redox imbalance and IL-17 responses in memory CD4 T cells from patients with psoriasis.

Scand J Immunol 2019 Jan 19;89(1):e12730. Epub 2018 Dec 19.

Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

All stages of the inflammatory process involved in T cell-mediated chronic skin disorders like psoriasis are affected by redox imbalance. On the other hand, Th17 cells have a critical role in the pathogenesis of psoriasis. In this study, we evaluated redox status in memory CD4 + T cells and plasma of patients with psoriasis and its correlation with IL-17 response. Read More

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http://doi.wiley.com/10.1111/sji.12730
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January 2019
9 Reads

LprG and PE_PGRS33 Mycobacterium tuberculosis virulence factors induce differential mitochondrial dynamics in macrophages.

Scand J Immunol 2019 Jan 30;89(1):e12728. Epub 2018 Nov 30.

Laboratorio de Inmunorregulación, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.

The interaction of a pathogen with its host cell takes place at different levels, including the bioenergetics adaptation of both the pathogen and the host cell in the course of an infection. In this regard, Mycobacterium tuberculosis infection of macrophages induces mitochondrial membrane potential (Δψm) changes and cytochrome c release, depending on the bacteria strain's virulence, and the mitochondrial dynamics is modified by pathogens, such as Listeria monocytogenes. Here, we investigated whether two M. Read More

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http://doi.wiley.com/10.1111/sji.12728
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January 2019
9 Reads

The DosR antigen Rv1737c from Mycobacterium tuberculosis confers inflammation regulation in tuberculosis infection.

Scand J Immunol 2019 Jan 23;89(1):e12729. Epub 2018 Nov 23.

School of Public Health, Lanzhou University, Lanzhou, China.

There is an urgent need to identify the potential risk factors for activating latent Mycobacterium tuberculosis infection. In this study, we evaluated the immune function of Rv1737c, which is a latency-associated antigen of dormancy survival regulator (DosR) of M. tuberculosis in a mouse model. Read More

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http://dx.doi.org/10.1111/sji.12729DOI Listing
January 2019
9 Reads

The roles of SOCS3 and STAT3 in bacterial infection and inflammatory diseases.

Scand J Immunol 2018 Dec;88(6):e12727

Translational Neuroscience & Neural Regeneration and Repair Institute/Institute of Cell Therapy, The People's Hospital of China Three Gorges University, Yichang, China.

The suppressor of cytokine signalling-3 (SOCS3) is well known as a feedback inhibitor of the Janus kinases-signal transducer and activator of transcription 3 (JAK/STAT3) signalling pathway, which mediates the signal transduction of many cytokines, growth factors and hormones during many cellular processes. The critical role of SOCS3 is manifested by its binding to both the JAK kinase and the cytokine receptor, which can result in the inhibition of STAT3 phosphorylation. STAT3 triggers variety of genes expression in response to cytokine (IL-6 family, IL-10) and growth factor stimulation and thus plays a critical role in many cellular biological processes involved in anti/pro-inflammatory responses, cell growth and cell death. Read More

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http://doi.wiley.com/10.1111/sji.12727
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December 2018
10 Reads

The real "danger" lies in the failure to confront fundamentals.

Authors:
Melvin Cohn

Scand J Immunol 2018 Dec 4;88(6):e12726. Epub 2018 Nov 4.

Conceptual Immunology Group, The Salk Institute, La Jolla, California.

Can we formulate a framework that would provide an agreed upon basis for discussions of immune behaviour? An attempt to do this is, in the end, the main goal of this essay. If you tell a physicist that you have invented a perpetual motion machine, he would not spend any time trying to reveal the flaw. Rather, he would shrug you off because in his framework, such a machine is an impossibility. Read More

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http://dx.doi.org/10.1111/sji.12726DOI Listing
December 2018
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Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment?

Scand J Immunol 2018 Dec 4;88(6):e12725. Epub 2018 Nov 4.

Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.

Psoriasis is an immune-mediated disease where the IL-23/Th17 axis as well as TNF comprise main targets of biological therapy. Immune profiling has so far not been embraced as a clinical tool. We aimed to investigate relationships between individual serum cytokine levels in 40 psoriasis patients before and after receiving biological therapy and Psoriasis Area and Severity Index (PASI) and Dermatological Life Quality Index (DLQI). Read More

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http://doi.wiley.com/10.1111/sji.12725
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http://dx.doi.org/10.1111/sji.12725DOI Listing
December 2018
3 Reads

Elevated levels of interleukin-33 are associated with allergic and eosinophilic asthma.

Scand J Immunol 2018 Oct 8:e12724. Epub 2018 Oct 8.

Department of Immunology and Allergology, Lithuanian University of Health Sciences, Eiveniu str. 2, LT-50009, Kaunas, Lithuania.

IL-33 is a recently discovered cytokine which plays an important role in asthma pathogenesis.

Aim: to evaluate serum IL-33 in patients with asthma and healthy controls, and to evaluate the association of IL-33 with different asthma phenotypes.

Methods: Patients with asthma (n=115) and healthy subjects (n=85) were included in the study. Read More

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http://doi.wiley.com/10.1111/sji.12724
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October 2018
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Associations of tumor necrosis factor-α polymorphisms with the risk of tuberculosis: a meta-analysis.

Scand J Immunol 2018 Sep 26:e12719. Epub 2018 Sep 26.

Department of Maternal and Child Tuberculosis, Xi'an Chest Hospital, Xi'an, China.

Recently, the roles of tumor necrosis factor-α (TNF-α) polymorphisms in tuberculosis (TB) were intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between TNF-α polymorphisms and the risk of TB. Eligible studies were searched in PubMed, Medline, Embase and CNKI. Read More

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http://doi.wiley.com/10.1111/sji.12719
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September 2018
3 Reads

Recovery from acute lung injury can be regulated via modulation of regulatory T cells and Th17 cells.

Scand J Immunol 2018 Nov 27;88(5):e12715. Epub 2018 Sep 27.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Acute lung injury (ALI) is a severe inflammatory disease, for which no specific treatment exists. The decreased ratio of regulatory T cells (CD4 CD25 FoxP3 Tregs) and Th17 cells is implicated in ALI and inflammation. We here investigated whether maintaining the balance of CD4 CD25 Foxp3 Tregs and Th17 cells can alleviate lung injury. Read More

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http://doi.wiley.com/10.1111/sji.12715
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November 2018
3 Reads

Decreased regulatory function of CD4CD25CD45RA T cells and impaired IL-2 signalling pathway in patients with type 2 diabetes mellitus.

Scand J Immunol 2018 Oct;88(4):e12711

Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

In this study, the frequency and function of CD4CD25CD45RA regulatory T cells (Treg) and intracellular IL-2 signalling molecules in patients with type 2 diabetes mellitus (T2DM) were investigated. Tregs and responder T cells (Tresp, CD4CD25 T cells) were sorted and suppression assays were performed using flow cytometry. Phosphorylation of signal transducer and activator of transcription-5 (pSTAT5) were assessed using flow cytometry. Read More

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http://doi.wiley.com/10.1111/sji.12711
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October 2018
5 Reads
1.882 Impact Factor

Patients with out-of-hospital cardiac arrest show decreased human leucocyte antigen-DR expression on monocytes and B and T lymphocytes after return of spontaneous circulation.

Scand J Immunol 2018 Oct 16;88(4):e12707. Epub 2018 Sep 16.

Department of Emergency Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Immune disorders are an important feature of patients with out-of-hospital cardiac arrest (OHCA) after return of spontaneous circulation (ROSC). However, the precise immune alterations in patients with OHCA that occur immediately after ROSC are unclear. In this study, we investigated human leucocyte antigen-DR (HLA-DR) expression on circulatory monocytes and B and T lymphocytes. Read More

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http://dx.doi.org/10.1111/sji.12707DOI Listing
October 2018
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Infliximab ameliorates tumor necrosis factor-alpha-induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro.

Scand J Immunol 2018 Nov 10;88(5):e12716. Epub 2018 Oct 10.

Laboratory for Proteomics and Metabolomics, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga", Mexico City, Mexico.

Insulin resistance is the inability to respond to insulin and is considered a key pathophysiological factor in the development of type 2 diabetes. Tumor necrosis factor-alpha (TNF-alpha) can directly contribute to insulin resistance by disrupting the insulin signalling pathway via protein-tyrosine phosphatase 1B (PTP1B) activation, especially in adipocytes. Infliximab (Remicade ) is a TNF-alpha-neutralizing antibody that has not been fully studied in insulin resistance. Read More

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November 2018
2 Reads

IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex.

Scand J Immunol 2018 Nov 10;88(5):e12717. Epub 2018 Oct 10.

Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.

The recently discovered IFN-λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN-λ4 can inhibit HIV infection. Here, we show that IFN-λ4 could suppress HIV infection of macrophages. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286684PMC
November 2018
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Concurrent cross-reactivity of microbiota-derived epitopes to both self and pathogens may underlie the "Hygiene hypothesis".

Scand J Immunol 2018 Oct 19;88(4):e12708. Epub 2018 Sep 19.

Tregeutix Inc., Orlando, Florida.

The current iteration of the "Hygiene hypothesis" proposes precipitous decline in exposure to conserved microbial products and metabolites in individuals in developed countries undermines innate self-nonself "training" of immune system leading to allergy and autoimmunity. However, lack of innate "training" alone fails to account for the antigen-driven nature of these immunopathologies. Here, we advance an alternative, antigen-specific interpretive framework, SPIRAL (Specific ImmunoRegulatory Algorithm) that predicts "loss" of commensal microbiota-derived epitopes cross-reactive to both self and pathogens, rather than conserved microbial moieties or metabolites, underlies the "Hygiene hypothesis. Read More

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October 2018
8 Reads

The monocyte locomotion inhibitory factor inhibits the expression of inflammation-induced cytokines following experimental contusion in rat tibia.

Scand J Immunol 2018 Sep 16;88(3):e12702. Epub 2018 Aug 16.

Laboratorio de Biomecánica, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra" (INRLGII), Mexico City, Mexico.

Entamoeba histolityca produces the monocyte locomotion inhibitory factor (MLIF), a pentapeptide with powerful anti-inflammatory properties. MLIF may regulate trauma-induced inflammation through the effects it exerts directly or indirectly on immune cells, modulating the production and/or expression of the cytokines involved in the inflammatory processes that occur after damage. The aim of the present study was to evaluate the effect of MLIF on production of pro/anti-inflammatory cytokines after contusion in the rat tibia. Read More

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http://dx.doi.org/10.1111/sji.12702DOI Listing
September 2018
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Impaired neutrophil extracellular traps and inflammatory responses in the peritoneal fluid of patients with liver cirrhosis.

Scand J Immunol 2018 Nov 10;88(5):e12714. Epub 2018 Oct 10.

Departamento de Fisiología, CIINDE, Universidad de Guadalajara/Instituto Dermatológico de Jalisco, Guadalajara, Jalisco, México.

Liver cirrhosis (LC) is an inflammatory process associated with impaired functions in adaptive and innate immune responses at both systemic and local levels, also referred as Cirrhosis-Associated Immune Dysfunction. In this study, we evaluated the functionality of neutrophils from ascitic fluid (AF) of patients with hepatic cirrhosis by testing their ability to generate neutrophil extracellular traps (NETs) in vitro. To further determine the activation state of neutrophils, expression of the activation markers CD66b, CD69, and CD80 on these cells was analysed by flow cytometry. Read More

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http://dx.doi.org/10.1111/sji.12714DOI Listing
November 2018
18 Reads

Acacetin regulated the reciprocal differentiation of Th17 cells and Treg cells and mitigated the symptoms of collagen-induced arthritis in mice.

Scand J Immunol 2018 Oct;88(4):e12712

Department of Rheumatoid Arthritis, Suzhou Hospital of Traditional Chinese Medicine, Suzhou City, Jiangsu Province, China.

Background And Aim: The immune-regulative effect of acacetin on the development of autoimmune arthritis remains unexplored. This study aims to investigate the potential effect of acacetin on the treatment of collagen-induced arthritis (CIA) in mice and clarify its underlying mechanism.

Methods And Results: In a type II collagen (CII)-induced autoimmune arthritis model, acacetin significantly repressed the incidence of CIA, prevented the pathological alteration, and reduced CII-specific IgG and IgG1 levels. Read More

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http://dx.doi.org/10.1111/sji.12712DOI Listing
October 2018
11 Reads

Regulation of fatty acid synthesis in immune cells.

Scand J Immunol 2018 Nov;88(5):e12713

Department of Emergency Intensive Care Unit, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Metabolic reprogramming plays a critical role in the important cellular metabolic alterations that occur during the activation of immune cells to enable them to adapt to the extracellular environment. Here, we review recent studies on how substrate availability and metabolites mediate the signalling pathways that regulate fatty acid synthesis (FAS) in different immune cells and how FAS determines cellular fate and function. The major regulators sterol regulatory element-binding proteins and liver X receptors, the key enzyme ATP citrate lyase and the PI3K-Akt-mTOR signalling axis play important roles in de novo FAS during a variety of biological events, including cellular proliferation and differentiation and the development of organelles and intracellular membrane components in immune cells. Read More

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November 2018
18 Reads