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    Incidence of autoimmune diseases in patients with scabies: a nationwide population-based study in Taiwan.
    Rheumatol Int 2017 Apr 18. Epub 2017 Apr 18.
    Graduate Institute of Life Sciences, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Road, Neihu District, Taipei, 114, Taiwan.
    Scabies is a commonly occurring infectious immune-mediated inflammatory skin disease. Immune-mediated inflammatory processes are also observed in autoimmune diseases. There have been very few previous studies; however, that have investigated the possible association between scabies and autoimmune diseases. Read More

    [Evaluation of practices in the management of scabies in children].
    Ann Dermatol Venereol 2017 Apr 10. Epub 2017 Apr 10.
    UMR 911, Inserm CRO2, « centre de recherche en oncologie biologique et oncopharmacologie », service de dermatologie, hôpital Timone, Aix-Marseille université, Assistance publique des Hôpitaux de Marseille, 13005 Marseille, France.
    Background: Scabies has been on the rise in France in recent years and has posed therapeutic problems, mainly due to the withdrawal of benzyl benzoate. The objective of this study was to describe prescribing practices for scabies in children.

    Methods: A national survey was conducted by means of a standardized questionnaire covering various clinical situations of scabies and the drugs used preferentially according to age, which was sent out between December 2014 and March 2015 to members of the clinical research group of the French Society of Paediatric Dermatology. Read More

    Epidemiological aspects of genital ulcers at the STI center of the National Institute of Public Hygiene (Abidjan, Côte d'Ivoire) 2008 to 2010.
    Med Sante Trop 2017 Feb;27(1):90-94
    Institut national d'hygiène publique (INHP), Abidjan Côte d'Ivoire.
    Genital ulcers are among the seven syndromes of sexually transmitted infections (STIs) identified in Côte d'Ivoire. Ulcerative STIs present a public health problem because of their frequency and their role in the spread of HIV. Our objective was to investigate the epidemiological characteristics of genital ulcers observed in the STI center of the National Institute of Public Hygiene in Abidjan. Read More

    Misdiagnosed crusted scabies in an AIDS patient leads to hyperinfestation.
    Cutis 2017 Mar;99(3):202-204
    University of Texas Medical Branch, Galveston, USA.
    Crusted scabies is a severe, highly contagious form of classic scabies caused by the mite Sarcoptes scabiei var hominis. Crusted scabies is more common in immunosuppressed populations and overcrowded environments. In this condition, the host's immune system is overwhelmed and unable to defend against the mites on the skin, resulting in hyperinfestation of the host. Read More

    Treatment of Human Scabies with Oral Ivermectin. Eczematous Eruptions as a New Non-Reported Adverse Event.
    Actas Dermosifiliogr 2017 Apr 3. Epub 2017 Apr 3.
    Department of Dermatology, Hospital Universitario La Princesa, Spain.
    Background: Oral ivermectin is an alternative therapy for human scabies infection due to its ease of administration and good safety profile. However, there is no definitive consensus on the optimal dosing regimen.

    Objective: To describe the treatment of human scabies with different dosages of oral ivermectin and the possible adverse events. Read More

    Symptomatic Raccoon Dogs and Sarcoptic Mange Along an Urban Gradient.
    Ecohealth 2017 Apr 3. Epub 2017 Apr 3.
    Regional Environmental Planning Inc, Tokyo, Japan.
    We quantitatively evaluated the effects of landscape factors on the distribution of symptomatic raccoon dogs with sarcoptic mange along an urban gradient. We used 246 camera traps (182 traps from April 2005 to December 2006; 64 traps from September 2009 to October 2010) to record the occurrence of asymptomatic and symptomatic raccoon dogs at 21 survey sites along an urban-rural gradient in the Tama Hills area of Tokyo. Each occurrence was explained in terms of the surrounding forest, agricultural, and grassland areas and additional factors (i. Read More

    Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour.
    Artif Cells Nanomed Biotechnol 2017 Apr 3:1-8. Epub 2017 Apr 3.
    a Pharmaceutical Sciences Research Centre, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , PR China.
    To avoid potential systematical toxicity, solid lipid nanoparticles (SLNs) were prepared as a vehicle for transdermal delivery of ivermectin (IVM) using hot homogenisation followed by ultrasonic method. The as-prepared SLNs were approximately spherical shape with good stability. IVM was encapsulated in amorphous form within SLNs and displayed prolonged release from SLNs without burst release due to high encapsulation efficiency (EE). Read More

    J Zoo Wildl Med 2017 Mar;48(1):265-268
    A young adult, female, free-ranging Japanese raccoon dog ( Nyctereutes procyonoides viverrinus) with scabies infection was found dead as a result of traumatic injuries presumed to reflect vehicular trauma. Necropsy showed a large solid mass located on the left ovarian region, occupying a third of the abdominal cavity. Histologically, the mass contained complex tissues derived from three germinal layers, with areas of cuboidal or columnar epithelium, keratinized squamous epithelium, bone, cartilage, and adipose tissue. Read More

    More bark than bite: Comparative studies are needed to determine the importance of canine zoonoses in Aboriginal communities. A critical review of published research.
    Zoonoses Public Health 2017 Mar 25. Epub 2017 Mar 25.
    One Health Research Group, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Qld, Australia.
    The objective of this review was to identify and critique over forty years of peer-reviewed literature concerned with the transmission of canine zoonoses to Aboriginal people and determine the zoonotic organisms documented in dogs in Australian Aboriginal communities. A systematic literature search of public health, medical and veterinary databases identified 19 articles suitable for critical appraisal. Thirteen articles documented the occurrence of recognized zoonotic organisms in dogs in Aboriginal communities, including Toxocara canis, Dirofilaria immitis, Streptococcus dysgalactiae, Rickettsia felis, Sarcoptes scabiei and Giardia. Read More

    Scabietic vasculitis: Report of 2 cases.
    Ann Dermatol Venereol 2017 Mar 18. Epub 2017 Mar 18.
    Service de dermatologie, hôpital Nord, chemin des Bourrely, 13015 Marseille, France.
    Background: The infectious causes of cutaneous vasculitis are well known and include streptococcal infections among others. Cases resulting from parasitic infection are less frequent. Scabies, which is currently on the increase, has only been reported in a few isolated cases. Read More

    Complement inhibition by Sarcoptes scabiei protects Streptococcus pyogenes - An in vitro study to unravel the molecular mechanisms behind the poorly understood predilection of S. pyogenes to infect mite-induced skin lesions.
    PLoS Negl Trop Dis 2017 Mar 9;11(3):e0005437. Epub 2017 Mar 9.
    QIMR Berghofer Medical Research Institute, Infectious Diseases Department, Herston, Brisbane, Australia.
    Background: On a global scale scabies is one of the most common dermatological conditions, imposing a considerable economic burden on individuals, communities and health systems. There is substantial epidemiological evidence that in tropical regions scabies is often causing pyoderma and subsequently serious illness due to invasion by opportunistic bacteria. The health burden due to complicated scabies causing cellulitis, bacteraemia and sepsis, heart and kidney diseases in resource-poor communities is extreme. Read More

    Tracking the Subtle Mutations Driving Host Sensing by the Plant Pathogen Streptomyces scabies.
    mSphere 2017 Mar-Apr;2(2). Epub 2017 Mar 1.
    InBioS-Centre for Protein Engineering, University of Liège, Institut de Chimie, Liège, Belgium.
    The acquisition of genetic material conferring the arsenal necessary for host virulence is a prerequisite on the path to becoming a plant pathogen. More subtle mutations are also required for the perception of cues signifying the presence of the target host and optimal conditions for colonization. The decision to activate the pathogenic lifestyle is not "taken lightly" and involves efficient systems monitoring environmental conditions. Read More

    Burden of human scabies in sub-Saharan African prisons: Evidence from the west region of Cameroon.
    Australas J Dermatol 2017 Mar 1. Epub 2017 Mar 1.
    Department of Parasitology and Mycology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
    Background/objectives: There is little data on the profile and magnitude of scabies in sub-Saharan African prisons. The present study aimed to assess the prevalence and determinants of scabies in prisons of the west region of Cameroon.

    Methods: We conducted a cross-sectional study from March to August 2014, and consecutively recruited volunteer detainees of three randomly selected prisons in the West Region of Cameroon. Read More

    Global Skin Disease Morbidity and Mortality: An Update From the Global Burden of Disease Study 2013.
    JAMA Dermatol 2017 Mar 1. Epub 2017 Mar 1.
    Institute for Health Metrics and Evaluation, University of Washington, Seattle.
    Importance: Disability secondary to skin conditions is substantial worldwide. The Global Burden of Disease Study 2013 includes estimates of global morbidity and mortality due to skin diseases.

    Objective: To measure the burden of skin diseases worldwide. Read More

    Scabies escaping detection until dermoscopy was applied.
    Dermatol Pract Concept 2017 Jan 31;7(1):49-50. Epub 2017 Jan 31.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Dermoscopy is already considered a fairly established method for diagnosing scabies. This is because dermoscopy enables the visualization both of the burrow and the mite itself, forming the so-called "jet with a contrail" structure. In the present report we present an extraordinary case of a patient with scabies lesions on the face and neck, which was misdiagnosed during sequential visits and underwent unnecessary surgical diagnostic procedures. Read More

    Scabies in a bilateral hand allograft recipient: An additional mimicker of acute skin rejection in vascularized composite allotransplantation.
    Transpl Infect Dis 2017 Feb 17. Epub 2017 Feb 17.
    Department of Nephrology, Edouard Herriot Hospital Group, Lyon, France.
    Vascularized composite tissue allografts include skin, which frequently undergoes, in the early post-graft period, acute rejections. The diagnosis of acute rejection may be difficult as it can be mimicked by several dermatoses. We present a bilateral hand allograft recipient who developed, 16. Read More

    Common Skin Conditions in Children: Skin Infections.
    FP Essent 2017 Feb;453:26-32
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Read More

    A scabies outbreak in a diabetic and collagen disease ward: Management and prevention.
    Exp Ther Med 2016 Dec 27;12(6):3711-3715. Epub 2016 Oct 27.
    Department of General Medicine and Emergency Care, Toho University School of Medicine, Omori Hospital, Ota-ku, Tokyo 143-8541, Japan.
    Scabies is an infection caused by Sarcoptes scabiei. In developed countries, scabies remains an important public health problem in hospitals and care facilities among elderly or immunocompromised patients. There are a number of medical providers who have not experienced scabies and there has been confusion surrounding its management and prevention. Read More

    Norwegian scabies - rare case of atypical manifestation.
    An Bras Dermatol 2016 Nov-Dec;91(6):826-828
    Hospital do Câncer de Cascavel (Uopeccan) - Cascavel (PR), Brazil.
    Human scabies affects all social classes and different races around the world. It is highly contagious, but the exact figures on its prevalence are unknown. A 19-year-old male patient was admitted to the emergency room reporting fever (38°C) and multiple lesions throughout the body, except face, soles, and palms. Read More

    Insight into scabies.
    JAAPA 2017 Feb;30(2):1-3
    At the time this article was written, Faye Mariz Razon was a student in the PA program at LSUHSC School of Allied Health. Emily Weidman-Evans is a clinical associate professor in the PA program at LSUHSC. The authors have disclosed no potential conflicts of interest, financial or otherwise.
    Scabies, an infectious disease caused by the scabies mite, manifests as an intensely pruritic skin rash. Children, the underprivileged, and patients with immunocompromise are at a higher risk of acquiring this contagious disease. Infectivity occurs worldwide in patients of all races, ages, and sex. Read More

    [Scabies of the nail unit in an infant].
    Ann Dermatol Venereol 2017 Jan 4. Epub 2017 Jan 4.
    Université François-Rabelais de Tours, 37000 Tours, France; Service de dermatologie, unité de dermatologie pédiatrique, CHRU de Tours, 37044 Tours cedex 9, France.
    Background: There are no guidelines regarding the management of scabies in infants and recurrence is common at this age. We report the case of an infant with subungual hyperkeratosis and ungual lesions subsequent to classic scabies.

    Patients And Methods: A 7-month-girl, treated 6 weeks earlier with esdepallethrin for scabies, consulted for acquired lesions on 3 toe nails. Read More

    Epidemiology, Diagnosis, and Treatment of Scabies in a Dermatology Office.
    J Am Board Fam Med 2017 1/2;30(1):78-84
    From the Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.
    Background: Scabies is a neglected skin disease, and little is known about current incidence and treatment patterns in the United States. The purpose of this study was to examine demographic data, treatment types, success of treatment, and misdiagnosis rate of scabies in an outpatient dermatology clinic.

    Methods: A retrospective chart review of patients diagnosed with scabies within the past 5 years was performed. Read More

    A new treatment regimen with permethrin in scabies.
    G Ital Dermatol Venereol 2016 Dec 16. Epub 2016 Dec 16.
    Postgraduate School of Dermatology and Venereology, University of Milan, Milan, Italy.
    Background: Topical permethrin, applied once daily, is considered as the most effective treatment in scabies.

    Methods: Eighty-nine adult immunocompetent patients with scabies were treated with 5% permethrin cream: 42 patients were treated with a single application/day (group I); 47 patients were treated with one application/day for two consecutive days (group II). Clinical diagnosis of scabies was confirmed by microscopical examinations. Read More

    Emergence of Novel Pathogenic Streptomyces Species by Site-Specific Accretion and cis-Mobilization of Pathogenicity Islands.
    Mol Plant Microbe Interact 2017 Jan 30;30(1):72-82. Epub 2017 Jan 30.
    Department of Plant Pathology, University of Florida, Gainesville, U.S.A.
    The main pathogenicity factor of Streptomyces species associated with the potato common scab disease is a nitrated diketopiperazine called thaxtomin A (ThxA). In Streptomyces scabiei (syn. S. Read More

    The Treatment of Scabies.
    Dtsch Arztebl Int 2016 Nov;113(45):757-762
    Division of Evidence-Based Medicine (dEBM), Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin; Department of Dermatology and Venereology, University Hospital Halle.
    Background: Scabies is a contagious infestation transmitted by skin-to-skin contact and sometimes by contact with contaminated material. The scabies mite burrows into the skin, producing a papular rash and severe itch at typical sites of predilection.

    Methods: We systematically reviewed the literature to compare the efficacy of various anti-scabies agents, including a calculation of relative risks and confidence intervals. Read More

    Pet-Related Infections.
    Am Fam Physician 2016 Nov;94(10):794-802
    School of Veterinary Sciences, University of Bristol, Langford, United Kingdom.
    Physicians and veterinarians have many opportunities to partner in promoting the well-being of people and their pets, especially by addressing zoonotic diseases that may be transmitted between a pet and a human family member. Common cutaneous pet-acquired zoonoses are dermatophytosis (ringworm) and sarcoptic mange (scabies), which are both readily treated. Toxoplasmosis can be acquired from exposure to cat feces, but appropriate hygienic measures can minimize the risk to pregnant women. Read More

    The effects of climate factors on scabies. A 14-year population-based study in Taiwan.
    Parasite 2016 1;23:54. Epub 2016 Dec 1.
    Graduate Institute of Life Sciences, National Defense Medical Center, 114 Tapei, Taiwan - Department of Pathology and Graduate Institute of Pathology and Parasitology, the Tri-Service General Hospital, National Defense Medical Center, 114 Tapei, Taiwan - Biobank Management Center of the Tri-Service General Hospital, National Defense Medical Center, 114 Tapei, Taiwan.
    Scabies is a common infectious disease and can cause severe outbreaks if not controlled quickly. Besides personal contact history, environmental factors are also important. This study analyzed the effects of environmental climate factors on the incidence of scabies in Taiwan. Read More

    Safety of Topical Medications for Scabies and Lice in Pregnancy.
    Indian J Dermatol 2016 Nov-Dec;61(6):583-587
    Dermatology and Pathology, Rutgers New Jersey Medical School and the Rutgers University School of Public Affairs and Administration Newark, New Jersey, USA.
    Medications should be employed with caution in women of childbearing age. Topical medications have little systemic absorption. Therefore, they are considered safer than oral or parenteral agents and less likely to be embryotoxic or fetotoxic. Read More

    A Study of Clinical Profile and Quality of Life in Patients with Scabies at a Rural Tertiary Care Centre.
    J Clin Diagn Res 2016 Oct 1;10(10):WC01-WC05. Epub 2016 Oct 1.
    Resident, Department of Dermatology and Venereology, Pramukhswami Medical College , Karamsad, Gujarat, India .
    Introduction: Scabies is a contagious disease primarily related to poverty and overcrowding, it rapidly spreads from person to person specially in people with poor hygiene. We come across many patients from rural areas with scabies. In India the incidence ranges from 13% to 59% in rural and urban areas. Read More

    S1 guidelines on the diagnosis and treatment of scabies - short version.
    J Dtsch Dermatol Ges 2016 Nov;14(11):1155-1167
    Department of Dermatology, Venereology and Allergology, University Hospital Würzburg.
    The goals of this German guideline are the improvement of diagnosis and therapy of scabies, the implementation of a coordinated action in outbreaks of scabies, and the control of this infestation in large migration or refugee flows.Sarcoptes scabiei var. hominis is transmitted by direct skin-to-skin contact of sufficient duration. Read More

    A clinical study of cutaneous changes in pregnancy.
    J Epidemiol Glob Health 2017 Mar 19;7(1):63-70. Epub 2016 Nov 19.
    Department of Dermatology, Government Medical College, Alappuzha, Kerala, India.
    Background/objective: Pregnant women experience a myriad of physiological and metabolic changes that affect different organ systems in the body. Cutaneous and appendageal alterations that manifest during pregnancy are largely modulated by hormonal, immunologic, and metabolic factors. Detailed reports encompassing physiological changes and specific dermatoses of pregnancy and effects of various dermatoses on pregnant women are scanty in literature. Read More

    Community seroprevalence survey for yaws and trachoma in the Western Division of Fiji.
    Trans R Soc Trop Med Hyg 2016 Dec 16;110(10):582-587. Epub 2016 Nov 16.
    Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Background: Both yaws and trachoma are endemic in several countries in the Pacific. In co-endemic countries there may be potential synergies between both control programmes.

    Methods: We undertook a cluster randomised trachoma and yaws seroprevalence survey of children in the Western Division of Fiji. Read More

    Molecular characterization of calmodulin from Sarcoptes scabiei.
    Parasitol Int 2017 Apr 10;66(2):1-6. Epub 2016 Nov 10.
    Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China. Electronic address:
    Scabies, caused by the mite Sarcoptes scabiei, is a highly contagious parasitic disease that affects millions of people and other mammals worldwide. Calmodulin (CaM) is an important calcium sensor that participates in various critical physiological processes. In this study, the CaM of Sarcoptes scabiei (SsCaM) was cloned and expressed, and sequence analyses were performed using bioinformatics tools. Read More

    [Scabies in childhood and adolescence].
    Hautarzt 2016 Dec;67(12):1007-1020
    Abteilung für translationale Dermatoinfektiologie, Westfälische Wilhelms-Universität, Münster, Deutschland.
    Scabies is a common parasitosis, occurring worldwide and at any age that impairs the quality of life of patients and their families by the itching and the stigmatization. The main aims of therapy are destroying the mites Sarcoptes scabiei var. hominis that infect the stratum corneum and reduction of the itching. Read More

    Opportunities for Integrated Control of Neglected Tropical Diseases That Affect the Skin.
    Trends Parasitol 2016 Nov 13;32(11):843-854. Epub 2016 Sep 13.
    Centre for International Child Health, University of Melbourne, Melbourne, Australia; Group A Streptococcal Research, Murdoch Childrens Research Institute, Melbourne, Australia.
    Many neglected tropical diseases (NTDs) affect the skin, causing considerable disability, stigma, and exacerbation of poverty. However, there has been relatively little investment into laboratory research, epidemiology, diagnostic tools or management strategies to control tropical skin disease. Integration may advance the control of skin disease across a range of domains, including mapping, diagnosis, clinical management, and community control measures such as mass drug administration. Read More

    Enzymatic hydrolysis by transition-metal-dependent nucleophilic aromatic substitution.
    Nat Chem Biol 2016 Dec 3;12(12):1031-1036. Epub 2016 Oct 3.
    School of Chemistry &Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA.
    Nitroaromatic compounds are typically toxic and resistant to degradation. Bradyrhizobium species strain JS329 metabolizes 5-nitroanthranilic acid (5NAA), which is a molecule secreted by Streptomyces scabies, the plant pathogen responsible for potato scab. The first biodegradation enzyme is 5NAA-aminohydrolase (5NAA-A), a metalloprotease family member that converts 5NAA to 5-nitrosalicylic acid. Read More

    Protective effects of Solanum cernuum extract against chromosomal and genomic damage induced by methyl methanesulfonate in Swiss mice.
    Biomed Pharmacother 2016 Oct 20;83:1111-1115. Epub 2016 Aug 20.
    University of Franca, Avenida Dr. Armando Salles de Oliveira, 201-Parque Universitário, 14404-600, Franca, São Paulo, Brazil. Electronic address:
    Solanum cernuum Vell is a Brazilian shrub or small tree, restricted to Southeast states of the country. The leaves are commercialized as "panacéia" and indicated for the treatment of urinary disorders, gonorrhea, scabies, skin diseases and as desobstruent, diuretic and antiarrhythmic. The hydroalcholic extract is active in the treatment of gastric ulcer. Read More

    Evaluation of three enzyme-linked immunosorbent assays for sarcoptic mange diagnosis and assessment in the Iberian ibex, Capra pyrenaica.
    Parasit Vectors 2016 Oct 21;9(1):558. Epub 2016 Oct 21.
    Servei d'Ecopatologia de Fauna Salvatge (SEFaS), Wildlife Health Service - Departament de Medicina i Cirurgia Animal, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, E-08193, Spain.
    Background: Sarcoptic mange is a contagious skin disease caused by the mite Sarcoptes scabiei, affecting different mammalian species worldwide including the Iberian ibex (Capra pyrenaica), in which mortalities over 90 % of the population have been reported. No efficient diagnostic methods are available for this disease, particularly when there are low mite numbers and mild or no clinical signs. In this study, three enzyme-linked immunosorbent assays (ELISA) developed for dog (ELISA A), Cantabrian chamois (Rupicapra pyrenaica parva) (ELISA B) and Alpine chamois (Rupicapra rupicapra) (ELISA C), were evaluated to detect specific antibodies (IgG) to sarcoptic mange in Iberian ibex sera. Read More

    [Waves of refugees represent challenge for European dermatologists].
    Hautarzt 2016 Dec;67(12):1021-1024
    Abteilung für Dermatologie und Venerologie, Landeskrankenhaus Feldkirch, Akademisches Lehrkrankenhaus, Carinagasse 47, 6800, Feldkirch, Österreich.
    With the increasing number of asylum seekers in recent months, European dermatologists have been confronted with rising numbers of patients with formerly rare skin diseases and unusual infectious skin diseases that were previously scarcely observed at our latitude. Thorough examination of the patients medical history, including the routes of travel and the country of origin of the patients, detailed clinical and laboratory examinations, and - if necessary - referral to a special treatment center allow rapid and targeted treatment. Read More

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