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    Analysis of Post Earthquake Disease Pattern in a Camp at Gyampesal Gorkha.
    Kathmandu Univ Med J (KUMJ) 2016 Jul-Sept.;14(55):249-253
    Department of Pediatrics, Manipal College of Medical Science, Pokhara, Nepal.
    Background A major earthquake occurred in Nepal on 25th April 2015 with magnitude of 7.8 causing mass panic amongst people. Objective To analyze scenario, experience and disease pattern of Post Earthquake camp at Gyampesal, Gorkha. Read More

    Screening for infectious diseases among asylum seekers newly arrived in Germany in 2015: a systematic single-centre analysis.
    Public Health 2017 Aug 8;153:1-8. Epub 2017 Aug 8.
    Department of Public Health, City of Augsburg, Augsburg, Germany; Department of Internal Medicine II, University Hospital of Ulm, Ulm, Germany. Electronic address:
    Objectives: During the migrant crisis in 2015, Germany was the largest single recipient of new asylum seekers in Europe. The German asylum law requires a screening examination for certain infectious diseases in asylum seekers upon arrival. The aim of this work was to analyse the rate of certain infectious diseases among asylum seekers screened at a reception centre in Southern Germany. Read More

    Host immune responses to the itch mite, Sarcoptes scabiei, in humans.
    Parasit Vectors 2017 Aug 10;10(1):385. Epub 2017 Aug 10.
    Inflammation & Healing Research Cluster, School of Health and Sport Sciences, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Locked Bag 4, Maroochydore DC, QLD, 4558, Australia.
    Scabies is a parasitic disease due to infestation of skin by the burrowing mite Sarcoptes scabiei. Scabies is a major public health problem and endemic in resource poor communities worldwide affecting over 100 million people. Associated bacterial infections cause substantial morbidity, and in severe cases can lead to renal and cardiac diseases. Read More

    Clinical Inquiry: What is the most effective treatment for scabies?
    J Fam Pract 2017 Aug;66(8):E11-E12
    University of Iowa, Iowa City, IA, USA.
    Evidence-based Answer: Topical permethrin is the most effective treatment for classic scabies (strength of recommendation [SOR]: A, meta-analyses with consistent results). Topical lindane and crotamiton are inferior to permethrin but appear equivalent to each other and benzyl benzoate, sulfur, and natural synergized pyrethrins (SOR: B, limited randomized trials). Although not as effective as topical permethrin, oral ivermectin is an effective treatment compared with placebo (SOR: B, a single small randomized trial). Read More

    The prevalence and association with health-related quality of life of tungiasis and scabies in schoolchildren in southern Ethiopia.
    PLoS Negl Trop Dis 2017 Aug 3;11(8):e0005808. Epub 2017 Aug 3.
    London School of Hygiene and Tropical Medicine, London, United Kingdom.
    Background: The prevalence of skin disease in low and middle income countries is high and communicable skin diseases are a significant public health problem. Tungiasis is an ectoparasite infestation caused by the flea Tunga penetrans, which has a widespread geographical distribution. Tungiasis causes painful skin lesions and may affect activities of daily living. Read More

    Biosynthesis and evolution of coronafacoyl phytotoxin production in the common scab pathogen Streptomyces scabies.
    Appl Environ Microbiol 2017 Jul 28. Epub 2017 Jul 28.
    Department of Biology, Memorial University of Newfoundland, St. John's, NL, Canada
    Coronafacoyl phytotoxins are an important family of plant toxins that are produced by several different phytopathogenic bacteria, including the gammaproteobacterium Pseudomonas syringae and the actinobacterium Streptomyces scabies. The phytotoxins consist of coronafacic acid (CFA) linked via an amide bond to different amino acids or amino acid derivatives. Previous work suggested that S. Read More

    Characterization of Sarcoptes scabiei Tropomyosin and Paramyosin: Immunoreactive Allergens in Scabies.
    Am J Trop Med Hyg 2017 Jul 10. Epub 2017 Jul 10.
    Inflammation and Healing Research Cluster, School of Health and Sport Sciences, University of the Sunshine Coast, Maroochydore, Queensland, Australia.
    Scabies is a human skin disease due to the burrowing ectoparasite Sarcoptes scabiei var. hominis resulting in intense itching and inflammation and manifesting as a skin allergy. Because of insufficient mite material and lack of in vitro propagation system for antigen preparation, scabies is a challenging disease to develop serological diagnostics. Read More

    The Epidemiology of Scabies and Impetigo in Relation to Demographic and Residential Characteristics: Baseline Findings from the Skin Health Intervention Fiji Trial.
    Am J Trop Med Hyg 2017 Jul 17. Epub 2017 Jul 17.
    Murdoch Children's Research Institute, Melbourne, Australia.
    Scabies and associated impetigo are under-recognised causes of morbidity in many developing countries. To strengthen the evidence base for scabies control we undertook a trial of mass treatment for scabies. We report on the occurrence and predictors of scabies and impetigo in participants at baseline. Read More

    Increased risk of bipolar disorder in patients with scabies: A nationwide population-based matched-cohort study.
    Psychiatry Res 2017 Jul 8;257:14-20. Epub 2017 Jul 8.
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan; Biobank Management Center of the Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Department of Pathology and Graduate Institute of Pathology and Parasitology, the Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address:
    Both scabies and bipolar disorder (BD) are common and troublesome disorders. There are several similarities in both diseases: pruritus, a higher prevalence in crowded environments, and cytokine-mediated inflammatory processes in the pathophysiology. We conducted this nationwide population-based study to investigate the possible relationship between scabies and BD. Read More

    Are scabies and impetigo "normalised"? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections.
    PLoS Negl Trop Dis 2017 Jul 3;11(7):e0005726. Epub 2017 Jul 3.
    Department of Infectious Diseases, Princess Margaret Hospital for Children, Perth, Western Australia.
    Background: Complications of scabies and impetigo such as glomerulonephritis and invasive bacterial infection in Australian Aboriginal children remain significant problems and the overall global burden of disease attributable to these skin infections remains high despite the availability of effective treatment. We hypothesised that one factor contributing to this high burden is that skin infection is under-recognised and hence under-treated, in settings where prevalence is high.

    Methods: We conducted a prospective, cross-sectional study to assess the burden of scabies, impetigo, tinea and pediculosis in children admitted to two regional Australian hospitals from October 2015 to January 2016. Read More

    Urologic Dermatology: a Review.
    Curr Urol Rep 2017 Aug;18(8):62
    Virginia Mason Medical Center, Seattle, WA, USA.
    Purpose Of Review: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic. Read More

    Bullous Pemphigoid: Use of C4d Immunofluorescent Staining in a Case With Repeated Negative Conventional Direct Immunofluorescence Studies.
    Am J Dermatopathol 2017 Jun 20. Epub 2017 Jun 20.
    *Department of Pathology, East Tennessee State University, Quillen College of Medicine, Johnson City, TN; †James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN; and ‡Department of Medicine, East Tennessee State University, Quillen College of Medicine, Johnson City, TN.
    Direct immunofluorescence (DIF) using frozen section material from a fresh/preserved perilesional biopsy is the gold standard for the immunopathologic diagnosis of bullous pemphigoid (BP). DIF in BP shows linear dermoepidermal junction (DEJ) staining for C3, with or without staining for IgG. In some situations, only a formalin-fixed lesional biopsy is obtained (with no fresh/preserved perilesional biopsy for DIF). Read More

    A review of Sarcoptes scabiei: past, present and future.
    Parasit Vectors 2017 Jun 20;10(1):297. Epub 2017 Jun 20.
    Department of Biological Sciences, Wright State University, 3640 Colonel Glenn Hwy, Dayton, OH, 45435, USA.
    The disease scabies is one of the earliest diseases of humans for which the cause was known. It is caused by the mite, Sarcoptes scabiei, that burrows in the epidermis of the skin of humans and many other mammals. This mite was previously known as Acarus scabiei DeGeer, 1778 before the genus Sarcoptes was established (Latreille 1802) and it became S. Read More

    Increasing prevalence of infectious diseases in asylum seekers at a tertiary care hospital in Switzerland.
    PLoS One 2017 15;12(6):e0179537. Epub 2017 Jun 15.
    Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, University Basel, Basel, Switzerland.
    Objective: The increasing number of refugees seeking asylum in Europe in recent years poses new challenges for the healthcare systems in the destination countries. The goal of the study was to describe the evolution of medical problems of asylum seekers at a tertiary care centre in Switzerland.

    Methods: At the University Hospital Basel, we compared all asylum seekers during two 1-year time periods in 2004/05 and 2014/15 concerning demographic characteristics and reasons for referrals and hospitalizations. Read More

    Identification of antigenic Sarcoptes scabiei proteins for use in a diagnostic test and of non-antigenic proteins that may be immunomodulatory.
    PLoS Negl Trop Dis 2017 Jun 12;11(6):e0005669. Epub 2017 Jun 12.
    Department of Biological Sciences, Wright State University, Dayton, OH, United States of America.
    Background: Scabies, caused by the mite, Sarcoptes scabiei, infects millions of humans, and many wild and domestic mammals. Scabies mites burrow in the lower stratum corneum of the epidermis of the skin and are the source of substances that are antigenic or modulate aspects of the protective response of the host. Ordinary scabies is a difficult disease to diagnose. Read More

    Gene silencing by RNA interference in Sarcoptes scabiei: a molecular tool to identify novel therapeutic targets.
    Parasit Vectors 2017 Jun 10;10(1):289. Epub 2017 Jun 10.
    QIMR Berghofer Medical Research Institute, Infectious Diseases Department, 300 Herston Road, Herston, Brisbane, 4006, Australia.
    Background: Scabies is one of the most common and widespread parasitic skin infections globally, affecting a large range of mammals including humans, yet the molecular biology of Sarcoptes scabiei is astonishingly understudied. Research has been hampered primarily due to the difficulty of sampling or culturing these obligatory parasitic mites. A further and major impediment to identify and functionally analyse potential therapeutic targets from the recently emerging molecular databases is the lack of appropriate molecular tools. Read More

    Increase the risk of intellectual disability in children with scabies: A nationwide population-based cohort study.
    Medicine (Baltimore) 2017 Jun;96(23):e7108
    aDivision of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan bDepartment of Medicine, National Yang-Ming University cGraduate Institute of Life Sciences dBiobank Management Center of the Tri-Service General Hospital eDepartment of Pathology and Graduate Institute of Pathology and Parasitology fDepartment of Obstetrics & Gynecology, Tri-Service General Hospital, National Defense Medical Center gInstitute of Bioinformatics and System Biology, National Chiao Tung University, Hsinchu hSchool of Chinese Medicine, College of Chinese Medicine, China Medical University iDepartment of Nursing, College of Medical and Health Science, Asia University jDepartment of Pediatrics, BinKun Women's and Children's Hospital, Taoyuan kDepartment of Pediatrics, MacKay Children's Hospital, Taipei lDepartment of Medicine, MacKay Medical College, New Taipei City mDepartment of Pediatrics and Infectious Disease, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan nDivision of Infection and Pathway Medicine, College of Medicine and Veterinary Medicine, the University of Edinburgh, Edinburgh, United Kingdom.
    Scabies is a common and distressing disease caused by the mite Sarcoptes scabiei var. hominis. Psychiatric disorder in childhood is an important disease and easily neglected. Read More

    Guideline for the diagnosis and treatment of scabies in Japan (third edition): Executive Committee of Guideline for the Diagnosis and Treatment of Scabies.
    • Authors:
    J Dermatol 2017 May 31. Epub 2017 May 31.
    The Japanese Dermatological Association, Tokyo, Japan.
    In the current work, we present our new guideline for the diagnosis and treatment of scabies which we, the Executive Committee convened by the Japanese Dermatological Association, developed to ensure proper diagnosis and treatment of scabies in Japan. Approval of phenothrin topical use under the National Health Insurance in August 2014 led to this action. Permethrin, a topical anti-scabietic medication belonging to the same pyrethroid group as phenothrin, is already in use worldwide. Read More

    In Vitro Efficacy of Moxidectin versus Ivermectin against Sarcoptes scabiei.
    Antimicrob Agents Chemother 2017 Aug 25;61(8). Epub 2017 Jul 25.
    QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
    Moxidectin is under consideration for development as a treatment for human scabies. As some arthropods show decreased sensitivity to moxidectin relative to ivermectin, it was important to assess this for Sarcoptes scabieiIn vitro assays showed that the concentration of moxidectin required to kill 50% of mites was lower than that of ivermectin (0.5 μM versus 1. Read More

    Systematic review of the diagnosis of scabies in therapeutic trials.
    Clin Exp Dermatol 2017 Jul 29;42(5):481-487. Epub 2017 May 29.
    Department of Paediatrics, Centre for International Child Health, University of Melbourne, Melbourne, Australia.
    Human scabies (infestation with the mite Sarcoptes scabiei var hominis) causes a significant disease burden worldwide, yet there are no agreed diagnostic guidelines. We aimed to determine whether a consistent approach to diagnosing scabies has been used for published scabies therapeutic trials. The data sources used were the MEDLINE, Embase and Cochrane databases, from 1946 to 29 August 2013. Read More

    Incidental mosquitocidal effect of an ivermectin mass drug administration on Anopheles farauti conducted for scabies control in the Solomon Islands.
    Trans R Soc Trop Med Hyg 2017 Mar;111(3):97-101
    Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
    Background: The Solomon Islands is targeting elimination of malaria by 2030. The dominant vector is the predominantly exophagic, exophilic Anopheles farauti sensu strictu. This biting behaviour limits the efficacy of conventional vector control tools and highlights the need for new strategies. Read More

    Transcriptome-microRNA analysis of Sarcoptes scabiei and host immune response.
    PLoS One 2017 23;12(5):e0177733. Epub 2017 May 23.
    Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.
    Scabies is a parasitic disease, caused by the mite Sarcoptes scabiei, and is considered one of the top 50 epidemic diseases and one the most common human skin disease, worldwide. Allergic dermatitis, including an intense itch, is a common symptom, however diagnosis is difficult and there is currently no effective vaccine. The goal of this study was to examine the immune interaction mechanism of both S. Read More

    Dermatology in Ghana: a retrospective review of skin disease at the Korle Bu Teaching Hospital Dermatology Clinic.
    Pan Afr Med J 2017 3;26:125. Epub 2017 Mar 3.
    The Ronald Perelman Department of Dermatology, New York University School of Medicine, USA.
    Introduction: Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. Read More

    Strongyloides seroprevalence before and after an ivermectin mass drug administration in a remote Australian Aboriginal community.
    PLoS Negl Trop Dis 2017 May 15;11(5):e0005607. Epub 2017 May 15.
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia.
    Background: Strongyloides seroprevalence is hyper-endemic in many Australian Aboriginal and Torres Strait Islander communities, ranging from 35-60%. We report the impact on Strongyloides seroprevalence after two oral ivermectin mass drug administrations (MDAs) delivered 12 months apart in a remote Australian Aboriginal community.

    Methods: Utilizing a before and after study design, we measured Strongyloides seroprevalence through population census with sequential MDAs at baseline and month 12. Read More

    Scabies: A clinical update.
    Aust Fam Physician 2017 ;46(5):264-268
    Background: Scabies is a common, yet neglected, skin disease. Scabies occurs across Australia, but most frequently in socioeconomically disadvantaged populations in tropical regions, including in remote Aboriginal and Torres Strait Islander communities. In temperate settings, the disease clusters in institutional care facilities. Read More

    A medical enigma : what "gale chinoise (Chinese scabies)" meant 150 years ago.
    Med Sante Trop 2017 Jun;27(2):126-130
    Centre René Labusquière, Université de Bordeaux 3, Bordeaux, France.
    Context: The meaning of the term "gale chinoise" mentioned in some articles about French overseas territories in the 19th century, remains unclear. In response to a query of an American colleague dermatologist trying to find out what it meant 150 years ago, we attempted to elucidate the nature of this ancient disease, which today would be translated literally as Chinese scabies.

    Method: We submitted the query to a panel of civilian and military French tropical medicine specialists including dermatologists, through two networks : Association Amicale Santé Navale et d'Outre-Mer and Société de Pathologie Exotique. Read More

    Anticancer potential of Thevetia peruviana fruit methanolic extract.
    BMC Complement Altern Med 2017 May 2;17(1):241. Epub 2017 May 2.
    Instituto de Biotecnología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Avenida Universidad S/N, Ciudad Universitaria, CP 66455, San Nicolás de los Garza, NL, Mexico.
    Background: Thevetia peruviana (Pers.) K. Schum or Cascabela peruviana (L. Read More

    Study of pruritus vulvae in geriatric age group in tertiary hospital.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):15-21
    Department of Dermatology, Venereology, Leprosy, Government Medical College, Amritsar, Punjab, India.
    Background: According to the World Health Organization criteria, geriatric population is people above 60 years of age. In this phase of life, a woman has already gone through menopause and its associated emotional, physical, and hormonal changes. These changes are due to gradual loss of estrogen that comes with menopause which results in dramatic changes in the appearance of vulva and vagina. Read More

    Recognizing common parasitic infestations.
    JAAPA 2017 May;30(5):1-6
    Judy Truscott is program director and an assistant professor in the PA program at Chatham University in Pittsburgh, Pa. Alyssa Abebe is an assistant professor at Chatham University and practices at an HIV research clinic at the University of Pittsburgh. Kelly Donkers is academic coordinator and an assistant professor in the PA program at Chatham University. Daria Segers is a senior PA with the University of Pittsburgh Physicians. The authors have disclosed no potential conflicts of interest, financial or otherwise.
    Parasitic infestations commonly are seen in patients in primary care, urgent care, and EDs. These infestations are a common cause of pruritus and may lead to secondary infestations. This article reviews the signs and symptoms of pinworms, lice, bedbug, and scabies infestations, as well as diagnosis and appropriate treatment. Read More

    The range of the mange: Spatiotemporal patterns of sarcoptic mange in red foxes (Vulpes vulpes) as revealed by camera trapping.
    PLoS One 2017 19;12(4):e0176200. Epub 2017 Apr 19.
    Norwegian Institute for Nature Research, Trondheim, Norway.
    Sarcoptic mange is a widely distributed disease that affects numerous mammalian species. We used camera traps to investigate the apparent prevalence and spatiotemporal dynamics of sarcoptic mange in a red fox population in southeastern Norway. We monitored red foxes for five years using 305 camera traps distributed across an 18000 km2 area. Read More

    Incidence of autoimmune diseases in patients with scabies: a nationwide population-based study in Taiwan.
    Rheumatol Int 2017 Jul 18;37(7):1125-1134. Epub 2017 Apr 18.
    Graduate Institute of Life Sciences, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Road, Neihu District, Taipei, 114, Taiwan.
    Scabies is a commonly occurring infectious immune-mediated inflammatory skin disease. Immune-mediated inflammatory processes are also observed in autoimmune diseases. There have been very few previous studies; however, that have investigated the possible association between scabies and autoimmune diseases. Read More

    [Evaluation of practices in the management of scabies in children].
    Ann Dermatol Venereol 2017 May 10;144(5):341-348. Epub 2017 Apr 10.
    UMR 911, Inserm CRO2, « centre de recherche en oncologie biologique et oncopharmacologie », service de dermatologie, hôpital Timone, Aix-Marseille université, Assistance publique des Hôpitaux de Marseille, 13005 Marseille, France.
    Background: Scabies has been on the rise in France in recent years and has posed therapeutic problems, mainly due to the withdrawal of benzyl benzoate. The objective of this study was to describe prescribing practices for scabies in children.

    Methods: A national survey was conducted by means of a standardized questionnaire covering various clinical situations of scabies and the drugs used preferentially according to age, which was sent out between December 2014 and March 2015 to members of the clinical research group of the French Society of Paediatric Dermatology. Read More

    Epidemiological aspects of genital ulcers at the STI center of the National Institute of Public Hygiene (Abidjan, Côte d'Ivoire) 2008 to 2010.
    Med Sante Trop 2017 Feb;27(1):90-94
    Institut national d'hygiène publique (INHP), Abidjan Côte d'Ivoire.
    Genital ulcers are among the seven syndromes of sexually transmitted infections (STIs) identified in Côte d'Ivoire. Ulcerative STIs present a public health problem because of their frequency and their role in the spread of HIV. Our objective was to investigate the epidemiological characteristics of genital ulcers observed in the STI center of the National Institute of Public Hygiene in Abidjan. Read More

    Misdiagnosed crusted scabies in an AIDS patient leads to hyperinfestation.
    Cutis 2017 Mar;99(3):202-204
    University of Texas Medical Branch, Galveston, USA.
    Crusted scabies is a severe, highly contagious form of classic scabies caused by the mite Sarcoptes scabiei var hominis. Crusted scabies is more common in immunosuppressed populations and overcrowded environments. In this condition, the host's immune system is overwhelmed and unable to defend against the mites on the skin, resulting in hyperinfestation of the host. Read More

    Treatment of Human Scabies with Oral Ivermectin. Eczematous Eruptions as a New Non-Reported Adverse Event.
    Actas Dermosifiliogr 2017 Apr 3. Epub 2017 Apr 3.
    Department of Dermatology, Hospital Universitario La Princesa, Spain.
    Background: Oral ivermectin is an alternative therapy for human scabies infection due to its ease of administration and good safety profile. However, there is no definitive consensus on the optimal dosing regimen.

    Objective: To describe the treatment of human scabies with different dosages of oral ivermectin and the possible adverse events. Read More

    Symptomatic Raccoon Dogs and Sarcoptic Mange Along an Urban Gradient.
    Ecohealth 2017 Jun 3;14(2):318-328. Epub 2017 Apr 3.
    Regional Environmental Planning Inc, Tokyo, Japan.
    We quantitatively evaluated the effects of landscape factors on the distribution of symptomatic raccoon dogs with sarcoptic mange along an urban gradient. We used 246 camera traps (182 traps from April 2005 to December 2006; 64 traps from September 2009 to October 2010) to record the occurrence of asymptomatic and symptomatic raccoon dogs at 21 survey sites along an urban-rural gradient in the Tama Hills area of Tokyo. Each occurrence was explained in terms of the surrounding forest, agricultural, and grassland areas and additional factors (i. Read More

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