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    An UPLC-MS/MS method for simultaneous determination of five flavonoids from Stellerachamaejasme L. in rat plasma and its application to a pharmacokinetic study.
    Biomed Chromatogr 2018 Jan 12. Epub 2018 Jan 12.
    Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
    Stellerachamaejasme L. has been used as a Traditional Chinese Medicine for the treatment of scabies, tinea, stubborn skin ulcers, chronic tracheitis, cancer and tuberculosis. A sensitive and selective ultra-high liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the simultaneous determination of five flavonoids (stelleranol, chamaechromone, neochamaejasmin A, chamaejasmine and isochamaejasmin) of Stellerachamaejasme L. Read More

    A Case Report of Real-Time in vivo Demonstration of Sarcoptes scabiei.
    Turkiye Parazitol Derg 2017 Dec;41(4):229-232
    Clinic of Dermatology, İstanbul Medeniyet University, Göztepe Training and Research Hospital, İstanbul, Turkey.
    Scabies is a pruritic dermatosis caused by the ectoparasite Sarcoptes scabiei var. hominis. The diagnosis of scabies is usually made on clinical grounds, but histopathological and/or dermoscopic examinations may sometimes be of assistance. Read More

    Sarcoptes scabiei on hedgehogs in New Zealand.
    Parasitol Res 2018 Jan 9. Epub 2018 Jan 9.
    School of Veterinary Science, Massey University, Palmerston North, New Zealand.
    European hedgehogs (Erinaceus europaeus) were introduced into New Zealand from Britain during the period from 1869 to the early 1900s. The only mite found on New Zealand hedgehogs in early studies was Caparinia tripilis, with Sarcoptes scabiei first being reported in 1996. The aim of this study was to investigate the prevalence of Sarcoptes infestation on hedgehogs in New Zealand, the number of mites found and the degree of mange observed. Read More

    Genetic background affects pathogenicity island function and pathogen emergence in Streptomyces.
    Mol Plant Pathol 2018 Jan 9. Epub 2018 Jan 9.
    Department of Plant Pathology, University of Florida, Gainesville, Florida, USA.
    With few exceptions, thaxtomin A (ThxA), a nitrated diketopiperazine, is the pathogenicity determinant for plant pathogenic Streptomyces species. In Streptomyces scabiei (syn. S. Read More

    The coronafacoyl phytotoxins: structure, biosynthesis, regulation and biological activities.
    Antonie Van Leeuwenhoek 2018 Jan 6. Epub 2018 Jan 6.
    Department of Biology, Memorial University of Newfoundland, St. John's, NL, A1B 3X9, Canada.
    Phytotoxins are secondary metabolites that contribute to the development and/or severity of diseases caused by various plant pathogenic microorganisms. The coronafacoyl phytotoxins are an important family of plant toxins that are known or suspected to be produced by several phylogenetically distinct plant pathogenic bacteria, including the gammaproteobacterium Pseudomonas syringae and the actinobacterium Streptomyces scabies. At least seven different family members have been identified, of which coronatine was the first to be described and is the best-characterized. Read More

    Lakartidningen 2017 Nov 7;114. Epub 2017 Nov 7.
    Statens Veterinärmedicinska Anstalt - Avdelningen för djurhälsa och antibiotikafrågor Uppsala, Sweden Statens Veterinärmedicinska Anstalt - Avdelning för djurhälsa och antibiotikafrågor Uppsala, Sweden.
    In case of pruritus, always consider scabies! Scabies is an itching skin disease caused by the mite Sarcoptes scabiei which affects more than 100 million people worldwide. Regarded as a neglected tropical disease by the WHO, it is a major public health burden in endemic areas. As direct skin-to-skin contact is the main route of transmission family members and sexual partners are often affected. Read More

    Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation.
    Allergol Immunopathol (Madr) 2017 Dec 23. Epub 2017 Dec 23.
    Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela.
    Scabies is observed with relatively high frequency in Allergy and Dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. Since the immunological response to scabies mites includes the production of IgE class antibodies to Sarcoptes scabiei allergens which cross-react with Dermatophagoides major allergens Der p 1 and Der p 2, positive immediate-type skin tests to house dust mite extracts should be interpreted cautiously. Additionally, scabies should be included routinely in the differential diagnosis of itchy rashes in patients living in those areas. Read More

    What's eating you? scabies in the developing world.
    Cutis 2017 Nov;100(5):287-289
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, USA.
    Scabies infestation is a major cause of impetigo and subsequent renal failure in the developing world, and efforts to eradicate widespread infestation are underway. Ivermectin, topical sulfur, and topical benzyl benzoate often are used to treat widespread outbreaks. Read More

    Disease Pattern among Children attending Pediatric Outpatient Department in Community Based Medical College Hospital, Bangladesh.
    Mymensingh Med J 2017 Oct;26(4):863-867
    Dr Maksuda Begum, Assistant Professor, Department of Community Medicine, Community Based Medical College, Bangladesh (CBMCB), Mymensingh, Bangladesh.
    Disease pattern is based on socio-demographic characteristics, comprehensive health care services, and environmental variables like water supply, basic sanitation and housing, illness behavior like quick decision to arrive at health care facility, and treatment behavior like the modality of treatment they receive. The descriptive cross-sectional study was conducted during the period of January 2014 to December 2015. The study was carried out among 310 purposively selected children attended at Pediatric Outpatient department of Community Based Medical College Hospital, Bangladesh. Read More

    Characterization of the catalytic signature of Scabin toxin, a DNA-targeting ADP-ribosyltransferase.
    Biochem J 2018 Jan 5;475(1):225-245. Epub 2018 Jan 5.
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Scabin was previously identified as a novel DNA-targeting mono-ADP-ribosyltransferase (mART) toxin from the plant pathogen 87.22 strain of Streptomyces scabies Scabin is a member of the Pierisin-like subgroup of mART toxins, since it targets DNA. An in-depth characterization of both the glycohydrolase and transferase enzymatic activities of Scabin was conducted. Read More

    Common Child and Adolescent Cutaneous Infestations and Fungal Infections.
    Curr Probl Pediatr Adolesc Health Care 2018 Jan 6;48(1):3-25. Epub 2017 Dec 6.
    Department of Dermatology, Wright State University, Boonshoft School of Medicine, Dayton, OH.
    Cutaneous infections and infestations are common among children and adolescents. Ectoparasitic infestations affect individuals across the globe. Head lice, body lice, scabies, and infestations with bed bugs are seen in individuals who reside in both resource poor areas and in developed countries. Read More

    Hospital admissions for skin infections among Western Australian children and adolescents from 1996 to 2012.
    PLoS One 2017 30;12(11):e0188803. Epub 2017 Nov 30.
    Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
    The objective of this study was to describe the occurrence of skin infection associated hospitalizations in children born in Western Australia (WA). We conducted a retrospective cohort study of all children born in WA between 1996 and 2012 (n = 469,589). Of these, 31,348 (6. Read More

    Scabies in the age of increasing drug resistance.
    PLoS Negl Trop Dis 2017 Nov 30;11(11):e0005920. Epub 2017 Nov 30.
    Department of Dermatology, American University of Beirut, Beirut, Lebanon.
    Scabies is an infestation of the skin by the mite Sarcoptes scabiei. It manifests with pruritic erythematous papules and excoriations, in addition to the pathognomonic burrows. Multiple drugs can be used for treatment, but resistance to conventional therapy is increasing throughout the years. Read More

    Crusted scabies due to indiscriminate use of glucocorticoid therapy in infant.
    An Bras Dermatol 2017 May-Jun;92(3):383-385
    Dermatology Service of the General Polyclinic of Rio de Janeiro (PGRJ) - Rio de Janeiro (RJ), Brazil.
    Crusted or Norwegian scabies is a parasitic infectious disease caused by Sarcoptes scabiei var. hominis that mainly affects immunocompromised individuals and those with neurological patients. We report a case of crusted scabies in a 4-month-old infant who had been treated erroneously for atopic dermatitis with high doses of corticosteroids. Read More

    Mitochondrial genome sequencing reveals potential origins of the scabies mite Sarcoptes scabiei infesting two iconic Australian marsupials.
    BMC Evol Biol 2017 Nov 28;17(1):233. Epub 2017 Nov 28.
    Centre for Animal Health Innovation, School of Science and Engineering, University of the Sunshine Coast, Sippy Downs, QLD, Australia.
    Background: Debilitating skin infestations caused by the mite, Sarcoptes scabiei, have a profound impact on human and animal health globally. In Australia, this impact is evident across different segments of Australian society, with a growing recognition that it can contribute to rapid declines of native Australian marsupials. Cross-host transmission has been suggested to play a significant role in the epidemiology and origin of mite infestations in different species but a chronic lack of genetic resources has made further inferences difficult. Read More

    Molecular characteristics and serodiagnostic potential of chitinase-like protein from Sarcoptes scabiei.
    Oncotarget 2017 Oct 19;8(48):83995-84005. Epub 2017 Sep 19.
    Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.
    Scabies, caused by the mite Sarcoptes scabiei, is an allergic skin disease that affects millions of people and other mammals worldwide. This highly contagious parasitic disease is among the top 50 epidemic disease and is regarded as a neglected tropical disease. Diagnosis of scabies is difficult in the early stage, and the pathogenesis of scabies is not currently clear. Read More

    [Diagnosis and treatment of scabies by general practitioners: A survey of practices in France].
    Ann Dermatol Venereol 2017 Nov 8. Epub 2017 Nov 8.
    Service de dermatologie, université de Franche-Comté, EA 3181, CHU, 3, boulevard Fleming, 25030 Besançon cedex, France. Electronic address:
    Background: Although there is evidence suggesting an epidemiologic increase of scabies in France, few studies have assessed medical practice in terms of diagnosis and treatment.

    Objectives: To describe the management of scabies by general practitioners (GPs).

    Patients And Methods: A questionnaire was addressed to the 524 GPs of the Doubs department in France regarding the management of cases of scabies diagnosed between January and June 2015. Read More

    Identification of a novel PYP-1 gene in Sarcoptes scabiei and its potential as a serodiagnostic candidate by indirect-ELISA.
    Parasitology 2017 Nov 8:1-10. Epub 2017 Nov 8.
    Department of Parasitology,College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,China.
    Scabies is a parasitic disease caused by the ectoparasite Sarcoptes scabiei, affecting different mammalian species, including rabbits, worldwide. In the present study, we cloned and expressed a novel inorganic pyrophosphatase, Ssc-PYP-1, from S. scabiei var. Read More

    A narrative review of dermatologic protocols for primary care medical service trips in Latin America and the Caribbean.
    Int J Dermatol 2017 Dec 31;56(12):1425-1431. Epub 2017 Oct 31.
    Medical Service Trip Inc., Toronto, Ontario, Canada.
    Background: Skin disorders are prevalent on primary care medical service trips in Latin America and the Caribbean and commonly include scabies, superficial mycoses, and pyoderma. There have been no previous attempts to describe protocols that international volunteer clinicians use in managing these patients. The purpose of this study was to collect North American clinical protocols used by sending organizations in their volunteer operations in Latin America and the Caribbean, summarize the most common pharmacologic and nonpharmacologic management strategies, and compare these to published international practice recommendations. Read More

    Contribution of the β-glucosidase BglC to the onset of the pathogenic lifestyle of Streptomyces scabies.
    Mol Plant Pathol 2017 Oct 27. Epub 2017 Oct 27.
    InBioS - Center for Protein Engineering, University of Liège, Institut de Chimie, Liège B-4000, Belgium.
    Common scab disease on root and tuber plants is caused by Streptomyces scabies and related species which use the cellulose synthase inhibitor thaxtomin A as the main phytotoxin. Thaxtomin production is primarily triggered by the import of cello-oligosaccharides. Once inside the cell, the fate of the cello-oligosaccharides is dichotomized: (i) the fuelling of glycolysis with glucose for the saprophytic lifestyle through the action of β-glucosidase(s) (BGs); and (ii) elicitation of the pathogenic lifestyle by the inhibition of CebR-mediated transcriptional repression of thaxtomin biosynthetic genes. Read More

    Increased risk of pernicious anemia following scabies: a nationwide population-based matched-cohort study.
    Ther Clin Risk Manag 2017 13;13:1205-1211. Epub 2017 Sep 13.
    Department of Pediatrics and Infectious Disease, Hsinchu MacKay Memorial Hospital, Hsinchu City, Taiwan.
    Objectives: Scabies is a common and annoying disorder. Pernicious anemia (PA) is a serious disease which, when untreated, leads to death. Mounting evidence suggests that immune-mediated inflammatory processes play a role in the pathophysiology of both diseases. Read More

    Single Domain Antibodies as New Biomarker Detectors.
    Diagnostics (Basel) 2017 Oct 17;7(4). Epub 2017 Oct 17.
    Clinical Tropical Medicine Laboratory, QIMR Berghofer Medical Research Institute, Brisbane 4029, Australia.
    Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for monitoring the progression of diseases. Antibodies represent promising tools for recognition of biomarkers, and are widely deployed as analytical tools in clinical settings. Read More

    Comparative Efficacy of Topical Pertmehrin, Crotamiton and Sulfur Ointment in Treatment of Scabies.
    J Arthropod Borne Dis 2017 Mar 14;11(1):1-9. Epub 2017 Mar 14.
    Ludwik Rydygier Voivodship Polyclinical Hospital, Toruń, Poland.
    Background: Scabies is an ectoparasitic infection, which occurs because of direct skin-to skin contact. The ideal treatment modality is still unclear and further research on this topic is warranted. The aim of the study was to compare the efficacy and safety of the topical scabicides: permethrin, crotamiton and sulfur ointment. Read More

    Case Report: Bullous Scabies in Two Children below 10 Years.
    Am J Trop Med Hyg 2017 Dec 21;97(6):1746-1748. Epub 2017 Sep 21.
    Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
    Bullous scabies is an infrequent and atypical presentation of scabies, with predilection for elderly and males. Its median age of presentation is 70 years. We report two male cases of bullous scabies who were 7 years and 6 months old. Read More

    Ignoring the "Itch": The Global Health Problem of Scabies.
    Am J Trop Med Hyg 2017 Dec 28;97(6):1647-1649. Epub 2017 Sep 28.
    Department of Dermatology, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
    Infestation with Sarcoptes scabiei var. hominis is a common human parasitic affliction endemic in tropical developing countries. Scabies is transmitted by close person-person contact, and outbreaks have been reported in reception centers for asylum seekers. Read More

    Scabies outbreak among healthcare workers in a German acute care hospital.
    J Infect Prev 2017 Jul 1;18(4):189-192. Epub 2017 Feb 1.
    Department of Dermatology, Venerology and Allergology, Chariteplatz 1, Berlin, Germany.
    Background: This article reports on a scabies outbreak among healthcare workers (HCW) in an acute care hospital. The outbreak was associated with a patient suffering from a chronic skin disease that was later diagnosed as crusted scabies.

    Objective: The objective was to determine the outbreak drivers and define a prevention strategy against future outbreaks. Read More

    Mucocutaneous manifestations in human immunodeficiency virus (HIV)-infected patients in Nouakchott, Mauritania.
    Int J Dermatol 2017 Dec 27;56(12):1421-1424. Epub 2017 Sep 27.
    Research Unit of Emerging Infectious and Tropical Diseases (URMITE), Institut de Recherche pour le Développement 198, Institut Hospitalo-Universitaire - Méditerranée Infection, Aix-Marseille University, Marseille, France.
    Background: Mucocutaneous manifestations are one of the first clinical signs in patients infected with human immunodeficiency virus (HIV). To the best of our knowledge, there has been no previous study describing dermatologic manifestations in Mauritanians infected with HIV. The aim of the present study was to determine the profiles of mucocutaneous manifestations in relation to CD4 T cell count in HIV-positive Mauritanian patients. Read More

    Norwegian scabies in a patient treated with Tripterygium glycoside for rheumatoid arthritis.
    An Bras Dermatol 2017 Jul-Aug;92(4):556-558
    Sino-French Cooperative Central Lab at Shanghai Gongli Hospital - Second Military Medical University - Shanghai, China.
    We report an 80-year-old male patient with severe rheumatoid arthritis who was treated with tripterygium glycoside, an immunosuppressive agent made from the extract of a Chinese medicinal herb called Tripterygium wilfordii Hook F. The patient had no apparent skin lesions before the treatment, but he developed aggressive hyperkeratotic lesions with rapid progression after using tripterygium glycoside. He was repeatedly diagnosed with eczema, but treatment failed to achieve efficacy. Read More

    Scabies-An ancient itch that is still rampant today.
    J Clin Pharm Ther 2017 Dec 25;42(6):793-799. Epub 2017 Sep 25.
    Faculty of Health, University of Tasmania, Hobart, TAS, Australia.
    What Is Known And Objective: Scabies is recognized as a neglected tropical disease responsible for a substantial health and economic burden, especially in resource-poor communities around the world.

    Comment: There are relatively few current treatment options for scabies, and they possess important limitations. The treatments are ineffective in preventing relapse, inflammatory skin reactions and associated bacterial skin infections. Read More

    Skin diseases of the male external genitalia in the Tanlangai Hospital in Brazzaville, Congo.
    Med Sante Trop 2017 Aug;27(3):296-300
    CHU Brazzaville, 13 avenue Auxence-IKonga, Brazzaville, Congo.
    To determine the frequency of diseases responsible for skin lesions of the male external genitalia. This descriptive retrospective study examined the medical records of patients older than 14 years treated for genital symptoms as outpatients at the Dermatology Department of Talangaï Hospital in Brazzaville in 2009-2011. Patients' sociodemographic, medical history, clinical, and laboratory data were collected on a standardized individual form. Read More

    The global burden of scabies: a cross-sectional analysis from the Global Burden of Disease Study 2015.
    Lancet Infect Dis 2017 Dec 21;17(12):1247-1254. Epub 2017 Sep 21.
    Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA; Dermatology Service, US Department of Veterans Affairs, Eastern Colorado Health System, Denver, CO, USA.
    Background: Numerous population-based studies have documented high prevalence of scabies in overcrowded settings, particularly among children and in tropical regions. We provide an estimate of the global burden of scabies using data from the Global Burden of Disease (GBD) Study 2015.

    Methods: We identified scabies epidemiological data sources from an extensive literature search and hospital insurance data and analysed data sources with a Bayesian meta-regression modelling tool, DisMod-MR 2·1, to yield prevalence estimates. Read More

    Scabies, Periorbital Cellulitis and Recurrent Skin Abscesses due to Panton-Valentine Leukocidin-Positive Staphylococcus aureus Mimic Hyper IgE Syndrome in an Infant.
    Pediatr Infect Dis J 2017 Dec;36(12):e347-e348
    From the *Department of Pediatric Pneumology and Immunology, ‡Department of Immunology, §Institute of Hygiene and Environmental Medicine, †Sozialpädiatrisches Zentrum, and ¶Department of Dermatology, Charité-Universitätsmedizin Berlin, Berlin, Germany; ‖Kinderarztpraxis Invalidenstr., Berlin, Germany; **Department of Pediatric Immunology and Rheumatology, ††Immunological Diagnostics Laboratory, Dr. von Hauner Childrens's Hospital, Ludwig-Maximilians-Universität, Munich, Germany; ‡‡Labor Berlin GmbH, Fachbereich Immunologie, Charité-Universitätsmedizin -Vivantes, Berlin, Germany; and §§Berlin Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Berlin, Germany.
    We describe the clinical course of a 2-month-old infant who was evaluated for autosomal dominant Hyper IgE Syndrome based on eczema, periorbital cellulitis, skin abscesses, increased total IgE levels and blood eosinophilia. However, scabies and nasal colonization by Panton-Valentine Leucocidin-positive S. aureus were eventually diagnosed. Read More

    Pyrethroids inhibit K2P channels and activate sensory neurons: basis of insecticide-induced paraesthesias.
    Pain 2017 Sep 25. Epub 2017 Sep 25.
    aNeurophysiology Laboratory, Physiology Unit, Department of Biomedicine, Medical School, Universitat de Barcelona, Barcelona, Spain bInstitute of Neurosciences, University of Barcelona, Barcelona, Spain cInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain dDpto. Biología de Sistemas, Edificio de Medicina Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
    Pyrethroid insecticides are widely used for pest control in agriculture or in human public health commonly as a topical treatment for scabies and head lice. Exposure to pyrethroids such as permethrin or tetramethrin (TM) causes sensory alterations such as transient pain, burning, stinging sensations, and paraesthesias. Despite the well-known effects of pyrethroids on sodium channels, actions on other channels that control sensory neuron excitability are less studied. Read More

    An endemic of scabies in Kahuta, Azad Kashmir. The study shows a lack of awareness of scabies; mass treatment is needed.
    J Pak Med Assoc 2017 Sep;67(9):1432-1433
    Army Medical Corps, Pakistan Army.
    The study was planned to find the awareness of scabies in the Forward Kahuta area of Azad Jammu and Kashmir, Pakistan. For this, a questionnaire related to scabies was distributed among the patients at different walk-in clinics in the region from June 2015 to May 2016. Of the 234 participants, 97(41. Read More

    Norwegian or Crusted Sarcoptic Mange in Two Leishmanial Dogs.
    J Am Anim Hosp Assoc 2017 Nov/Dec;53(6):326-330. Epub 2017 Sep 11.
    From the Alphavet Clinic, Athens, Greece (F.K.); Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece (R.F.); and Quality Vet Practice, Volos, Greece (A.F.K.).
    Norwegian or crusted scabies (N/CS) is a rare skin disease with very few cases reported in the dog or the cat. Two adult, stray dogs were admitted in our clinic with a generalized, multifocal to diffuse and nonpruritic dermatitis that was characterized by severe crusting, scaling, and ulceration. In both instances, leishmaniosis and N/CS were diagnosed by immunofluorescent antibody test serology, lymph node cytology, and skin scrapings in which high numbers of Sarcoptes mites were found. Read More

    The association between scabies and myasthenia gravis: A nationwide population-based cohort study.
    J Clin Neurosci 2017 Nov 7;45:115-120. Epub 2017 Sep 7.
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan; Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan. Electronic address:
    Scabies is an infectious inflammatory pruritic skin disease. Cytokine-mediated inflammatory processes contribute to the pathologic mechanism in scabies. Myasthenia gravis (MG) is also an autoimmune disease that is mediated by cytokines. Read More

    Scabies masquerading as bullous pemphigoid: scabies surrepticius.
    Clin Cosmet Investig Dermatol 2017 23;10:317-324. Epub 2017 Aug 23.
    Department of Dermatology, University of California San Diego, La Jolla, CA, USA.
    Scabies, a parasitic infestation caused by the mite Sarcoptes scabiei, is diagnosed by observing either the mite, its ova, or its excrement. The mite tracts, known as burrows and a characteristic presentation of the pruritic condition, are typically found on the web spaces between the fingers. Other cutaneous lesions include excoriated papules, pustules, and vesicles. Read More

    Scabies Associated with Granulomatous Dermatitis.
    Case Rep Dermatol 2017 May-Aug;9(2):60-64. Epub 2017 Jul 13.
    Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida, USA.
    Scabies is a relatively common parasitic infection, which has sometimes been associated with the formation of granuloma annulare. We report the case of an 86-year-old female who developed a non-necrotizing granulomatous dermatitis after a scabies infestation. This case highlights the importance of considering scabies in the differential diagnosis when granulomatous dermatitis is noted histologically that cannot be explained by other causes. Read More

    Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function.
    J Allergy Clin Immunol 2017 Aug 30. Epub 2017 Aug 30.
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.
    Background: Sumoylation is a posttranslational reversible modification of cellular proteins through the conjugation of small ubiquitin-related modifier (SUMO) and comprises an important regulator of protein function.

    Objective: We sought to characterize the molecular mechanism of a novel mutation at the SUMO motif on signal transducer and activator of transcription 1 (STAT1).

    Methods: STAT1 sequencing and functional characterization were performed in transfection experiments by using immunoblotting and immunoprecipitation in STAT1-deficient cell lines. Read More

    Expression and characterisation of a Sarcoptes scabiei protein tyrosine kinase as a potential antigen for scabies diagnosis.
    Sci Rep 2017 Aug 29;7(1):9639. Epub 2017 Aug 29.
    Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, 611130, China.
    Scabies is a disease that harms humans and other animals that is caused by the itch mite Sarcoptes scabiei burrowing into the stratum corneum of the skin. In the early stages of scabies, symptoms are often subclinical and there are no effective diagnostic methods. Herein, we cloned, expressed and characterised an S. Read More

    Acute postinfectious glomerulonephritis associated with scabies in the elderly: A case report.
    Parasitol Int 2017 Dec 26;66(6):802-805. Epub 2017 Aug 26.
    Department of Nephrology, Xijing Hospital, Xi'an, Shaanxi, China. Electronic address:
    Acute postinfectious glomerulonephritis (GN) secondary to scabies were mainly documented as early as in 1980s, and in all these published cases no histopathological evidence of renal biopsy were reported regarding scabies and renal damage. The delay in scabies treatment can result in a greater risk of secondary bacterial infections that can become invasive and/or lead to severe post-infective complications such as post-streptococcal glomerulonephritis. In diagnostic procedures, the clinical presentation of scabies is often atypical especially in elderly people patients. Read More

    Scabies in babies.
    Pediatr Dermatol 2017 Nov 22;34(6):690-694. Epub 2017 Aug 22.
    Division of Pediatric Dermatology, Johns Hopkins Children's Center, Baltimore, MD.
    The clinical manifestations of scabies infestation vary according to age, making the diagnosis challenging, particularly for primary care providers and dermatologists who do not routinely care for young children. We present seven cases of newborns and infants who developed inflammatory burrows and nodules early in the course, which is not typical of the eruption seen in older children and adults. We review the cutaneous features, differential diagnosis, and treatment recommendations for scabies in different age groups. Read More

    Allergen homologs in the Euroglyphus maynei draft genome.
    PLoS One 2017 22;12(8):e0183535. Epub 2017 Aug 22.
    Department of Biological Sciences, Wright State University, Dayton, Ohio, United States of America.
    Euroglyphus maynei is a house dust mite commonly found in homes worldwide and is the source of allergens that sensitize and induce allergic reactions in humans. It is the source of species-specific allergens as well as allergens that are cross-reactive with the allergens from house dust mites Dermatophagoides farinae and D. pteronyssinus, and the ectoparasitic scabies mite Sarcoptes scabiei. Read More

    Analysis of Post Earthquake Disease Pattern in a Camp at Gyampesal Gorkha.
    Kathmandu Univ Med J (KUMJ) 2016 Jul-Sept.;14(55):249-253
    Department of Pediatrics, Manipal College of Medical Science, Pokhara, Nepal.
    Background A major earthquake occurred in Nepal on 25th April 2015 with magnitude of 7.8 causing mass panic amongst people. Objective To analyze scenario, experience and disease pattern of Post Earthquake camp at Gyampesal, Gorkha. Read More

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