An UPLC-MS/MS method for simultaneous determination of five flavonoids from Stellerachamaejasme L. in rat plasma and its application to a pharmacokinetic study.
- Yun-Qing Li,
- Cheng-Jian Li,
- Lei Lv,
- Qing-Qing Cao,
- Xian Qian,
- Si Wei Li,
- Hui Wang,
- Liang Zhao
Biomed Chromatogr 2018 Jan 12. Epub 2018 Jan 12.
Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Stellerachamaejasme L. has been used as a Traditional Chinese Medicine for the treatment of scabies, tinea, stubborn skin ulcers, chronic tracheitis, cancer and tuberculosis. A sensitive and selective ultra-high liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the simultaneous determination of five flavonoids (stelleranol, chamaechromone, neochamaejasmin A, chamaejasmine and isochamaejasmin) of Stellerachamaejasme L. Read More