76,550 results match your criteria Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation Saudi Arabia[Journal]


Recipient ABCB1, donor and recipient CYP3A5 genotypes influence tacrolimus pharmacokinetics in liver transplant cases.

Pharmacol Rep 2019 Jan 11;71(3):385-392. Epub 2019 Jan 11.

Dept of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.

Background: Effective immunosuppression through optimization of trough levels tacrolimus reduces post-transplant mortality rate in liver transplant cases.

Methods: Meta-analysis was carried out to evaluate how donor/recipient CYP3A5 (n = 678) and recipient ABCB1 (n = 318) genotypes influence tacrolimus pharmacokinetics till one-month of transplantation.

Results: The donor CYP3A5*3/*3 genotype exhibited higher concentration/dose (C/D) ratio of tacrolimus in week 1 (mean difference: 65. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.006DOI Listing
January 2019

Synthesis, molecular properties and comparative docking and QSAR of new 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid derivatives as possible anticancer agents.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 7;218:248-262. Epub 2019 Apr 7.

Chemistry Department, Faculty of Science, Al-Azhar University (Boys Branch), Nasr City, Cairo, Egypt.

Novel coumarin amino acid derivatives were synthesized. The structure of synthesized compounds has established on basis of different spectral data. The optimization geometry, frontier molecular orbitals (FMOs), thermodynamic parameters and chemical reactivity, were discussed using DFT\B3LYP by 6-311G* basis set, to identify a clear view for inter and intramolecular interaction of tested compounds. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193019
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http://dx.doi.org/10.1016/j.saa.2019.02.074DOI Listing
April 2019
1 Read

Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic stem cell transplantation program in countries with limited resources (Part II): clinical, technical and socio-economic considerations.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Center for Hematopoietic Stem Cell Transplantation, Aichi Medical University Hospital, Nagakute; Department of Hematology and Medical Oncology, University Hospital, Leipzig, Germany.

The development of hematopoietic stem cell transplantation (HSCT) programs can face significant challenges in most developing countries because such endeavors must compete with other government health care priorities, including the delivery of basic services. While this is may be a limiting factor, these countries should prioritize development of the needed expertise to offer state of the art treatments including transplantation, by providing financial, technological, legal, ethical and other needed support. This would prove beneficial in providing successful programs customized to the needs of their population, and potentially provide long-term cost-savings by circumventing the need for their citizens to seek care abroad. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.012DOI Listing

Safety-Engineered Syringes: An Intervention to Decrease Hepatitis C Burden in Developing Countries-A Cost-Effectiveness Analysis from Egypt.

Value Health Reg Issues 2019 Apr 16;19:51-58. Epub 2019 Apr 16.

HTA Office, L.L.C., Cairo, Egypt; Pharmacy Practice Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt. Electronic address:

Introduction: To assess the cost-effectiveness of introducing the safety-engineered syringe (SES) to decrease hepatitis C burden resultant from unsafe injection practices in healthcare settings.

Methods: A Markov process model for a hypothetical study cohort was developed over a 30-year time horizon to compare the adoption of SES use with the current strategy, conventional syringes (CS), in the Egyptian healthcare settings. The national treatment program was applied in both groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22121099193003
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http://dx.doi.org/10.1016/j.vhri.2018.11.009DOI Listing
April 2019
1 Read

Effect of symbiotic supplemented diet on innate-adaptive immune response, cytokine gene regulation and antioxidant property in Labeo rohita against Aeromonas hydrophila.

Fish Shellfish Immunol 2019 Apr 16. Epub 2019 Apr 16.

Department of Herbal and Environmental Science, Tamil University, Thanjavur, 613 005, Tamil Nadu, India.

Administration of probiotic, prebiotic or symbiotic supplemented diets boosts the antioxidant property, pro and/or anti-inflammatory cytokine gene transcription, innate-adaptive immunity, growth rate and feed digestibility with very low or no mortality in healthy and infected (both groups) in Labeo rohita against Aeromonas hydrophila is reported. The probiotic diet increased the white blood cell (WBC) count and globulin (GB) level significantly on or after 6th week whereas with the symbiotic diet the increase was noted two weeks earlier in both groups; the total protein (TP) level also increased significantly when fed with probiotic diet on weeks 6 and 8, whereas with symbiotic diet the significant increase manifested earlier at 4th week itself. The serum phagocytic activity (PA), respiratory burst activity (RBA), complement C3 (CC3) level, alternative complement pathway (ACP), lysozyme activity (LA), and immunoglobulin M (IgM) levels in head kidney (HK) leucocytes increased significantly (P < 0. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.036DOI Listing

Pregabalin affords retinal neuroprotection in diabetic rats: Suppression of retinal glutamate, microglia cell expression and apoptotic cell death.

Exp Eye Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology and Toxicology, Faculty of Pharmacy (girls), Al-Azhar University, Cairo, Egypt.

Pregabalin is the first drug to receive FDA approval for treating diabetic neuropathic pain. This study investigated the neuroprotective effect of pregabalin in an experimental model of diabetic retinopathy and tested some possible mechanisms underlying the putative neuroprotective effect. Male Wistar rats received streptozotocin (45 mg/kg) to induce type 1 diabetes mellitus. Read More

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http://dx.doi.org/10.1016/j.exer.2019.04.014DOI Listing

Functionalization at Will of Rim-Differentiated Pillar[5]arenes.

Org Lett 2019 Apr 19. Epub 2019 Apr 19.

Institute for Molecular Design and Synthesis, School of Pharmaceutical Science & Technology , Tianjin University , 92 Weijin Road, Nankai District , Tianjin , 300072 , People's Republic of China.

The development of an efficient synthetic route toward rim-differentiated C-symmetric pillar[5]arenes (P[5]s), whose two rims are decorated with different chemical functionalities, opens up successive transformations of this macrocyclic scaffold. This paper describes a gram-scale synthesis of a C-symmetric penta-hydroxy P[5] precursor, and a range of highly efficient reactions that allow functionalizing either rim at will via, e.g. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b01123DOI Listing

Evaluation of the fit of zirconia three-unit fixed partial dentures fabricated by different impression techniques.

J Investig Clin Dent 2019 Apr 18:e12413. Epub 2019 Apr 18.

Department of Research and Prosthodontics, Faculty of Dental Medicine, Lebanese University, Hadath, Lebanon.

Aim: The aim of the present study was to evaluate the marginal and internal fit of zirconium fixed partial denture using different impression techniques.

Methods: A Nissin Typodont model, including maxillary central incisor and canine with missing lateral incisor, was selected for the present study. Thirty zirconium frameworks were fabricated following three impression techniques (N = 10), conventional silicone impression (group C), scanned dental impression (group S), and Trios 3 (3Shape) intraoral scanner (group T). Read More

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http://dx.doi.org/10.1111/jicd.12413DOI Listing

Revision of Sleeve Gastrectomy with Hiatal Repair with Gastropexy for Gastroesophageal Reflux Disease.

Obes Surg 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan.

Background: Gastroesophageal reflux disease (GERD) is the major drawback of laparoscopic sleeve gastrectomy (LSG). Conversion to Roux-en-Y bypass is recommended but might not be suitable for all patients.

Methods: We retrospectively reviewed the data of patients who underwent laparoscopic hiatal repair and gastropexy for intractable GERD after LSG between 2015 and 2017. Read More

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http://dx.doi.org/10.1007/s11695-019-03853-0DOI Listing

Visualizing faculty development impact: A social network analysis.

Perspect Med Educ 2019 Apr 18. Epub 2019 Apr 18.

Duke-NUS Medical School, Academic Medicine Education Institute, Singapore, Singapore.

Faculty development programs have tended to focus on low levels of evaluation such as participant satisfaction rather than assess the actual changes that training has brought about in the workplace. This has prompted scholars to suggest using social network analysis as a means to provide a more rigorous method of evaluating the impact of faculty development. To test the feasibility of such a suggestion, we used the social network analysis concepts of social cohesion to assess the impact of a year-long fellowship program conducted by Duke-NUS Medical School's Academic Medicine Education Institute (AM·EI). Read More

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http://dx.doi.org/10.1007/s40037-019-0510-9DOI Listing

Early signs of middle cerebral artery infarction on multidetector computed tomography: Review of 20 cases.

Brain Circ 2019 Jan-Mar;5(1):27-31. Epub 2019 Mar 27.

Department of Diagnostic Radiologic Technology, College of Applied Medical Sciences, Taibah University, Almadinah Almunawarah, Medina, Saudi Arabia.

Objective: This study intended to assess the occurrence of early signs of middle cerebral artery (MCA) on multidetector computed tomography (MDCT) in correlation with duration of the clinical features of stroke.

Patients And Methods: This retrospective study analyzed the electronic records of 20 patients with MCA infarction. The detected signs studied according to the onset of the clinical features of stroke to the time of CT imaging. Read More

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http://dx.doi.org/10.4103/bc.bc_28_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458774PMC

Applying Machine Learning of Erythrocytes Dynamic Antigens Store in Medicine.

Front Mol Biosci 2019 3;6:19. Epub 2019 Apr 3.

Computer Science Department, Faculty of Computing and Information Technology, King Abdulaziz University, Jeddah, Saudi Arabia.

Erythrocytes Dynamic Antigens Store (EDAS) is a new discovery. EDAS consists of self-antigens and foreign (non-self) antigens. In patients with infectious diseases or malignancies, antigens of infection microorganism or malignant tumor exist in EDAS. Read More

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https://www.frontiersin.org/article/10.3389/fmolb.2019.00019
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http://dx.doi.org/10.3389/fmolb.2019.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456707PMC
April 2019
1 Read

45S5 Bioglass paste is capable of protecting the enamel surrounding orthodontic brackets against erosive challenge.

J Orthod Sci 2019 20;8. Epub 2019 Feb 20.

Department of Orthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.

Objectives: This study aimed at evaluating the effect of using a 45S5 bioglass paste and a topical fluoride as protective agents against acidic erosion (resembling acidic beverage softdrinks intake) for enamel surrounding orthodontic brackets.

Materials And Methods: Sample of 21 freshly extracted sound incisor and premolar teeth was randomly divided into three equal groups: a bioglass group (Bioglass) (NovaMin, 5-mm average particle, NovaMin Technology), a Fluoride group (Fluoride) (Gelato APF Gel, Keystone Industries), and a control group (Control). Orthodontic brackets were bonded to the utilized teeth usingMIP (Moisture Insensitive Primer) and Transbond PLUS color change adhesive. Read More

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http://dx.doi.org/10.4103/jos.JOS_93_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416995PMC
February 2019

Comparative evaluation of the maxillary canine retraction rate and anchorage loss between two types of self-ligating brackets using sliding mechanics.

J Orthod Sci 2019 20;8. Epub 2019 Feb 20.

Department of Preventive Dental Sciences, Faculty of Dentistry, Najran University, Saudi Arabia.

Objective: To evaluate the maxillary canine retraction rate and anchorage loss with active and passive self-ligating brackets (SLBs).

Materials And Methods: The study was conducted on 10 patients whose age ranged from 14-20 years. The patients had minimal to no crowding with a dental protrusion of maxillary incisor that required the extraction of maxillary first premolars and retraction of canines. Read More

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http://dx.doi.org/10.4103/jos.JOS_73_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416991PMC
February 2019

Prevalence of malocclusion among school children of Southern Saudi Arabia.

J Orthod Sci 2019 20;8. Epub 2019 Feb 20.

Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Khalid University, Abha, Saudi Arabia.

Objective: To evaluate the status of occlusion among school children in city of Abha, Saudi Arabia.

Materials And Methods: The current study was based on the clinical examination of 1998 Saudis (mean age 14.13 ± 0. Read More

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http://www.jorthodsci.org/text.asp?2019/8/1/2/252618
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http://dx.doi.org/10.4103/jos.JOS_83_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416993PMC
February 2019
1 Read

Agreement and association between normative and subjective orthodontic treatment need using the Index of Orthodontic Treatment Need.

J Orthod Sci 2019 20;8. Epub 2019 Feb 20.

Department of Orthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Aims: To determine the association and level of agreement between young adults' perception of orthodontic treatment need (subjective need) and the orthodontists' assessment of treatment need (normative objective need).

Methodology: For this study, 670 students [280 males and 390 females; mean age (standard deviation) of 15.32 (1. Read More

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http://dx.doi.org/10.4103/jos.JOS_87_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416992PMC
February 2019

Pediatric diaphragmatic pacing.

Pediatr Rep 2019 Feb 11;11(1):7973. Epub 2019 Mar 11.

King Abdullah Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia.

Diaphragmatic pacing has been shown to play a significant role in adult patients with diaphragmatic paralysis and facilitates mechanical ventilation weaning. However, reports on its use in paediatric patients are scarce. This report is about a 4-year-old child with a spinal cord injury secondary to a motor vehicle accident that led to quadriplegia and diaphragm paralysis. Read More

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http://dx.doi.org/10.4081/pr.2019.7973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444561PMC
February 2019

Detecting the Second Mesiobuccal Canal in Maxillary Molars in a Saudi Arabian Population: A Micro-CT Study.

Scanning 2019 13;2019:9568307. Epub 2019 Mar 13.

Restorative and Prosthetic Dental Sciences, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, Saudi Arabia.

The aim of this study was to determine MB2 canal detectability in maxillary first and second molars obtained from a Saudi population using micro-CT. Maxillary first ( = 35) and second ( = 30) molars were scanned with micro-CT technology. The number of canals was recorded, and in case of having more than one canal, the level of extracanal detection was analyzed. Read More

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http://dx.doi.org/10.1155/2019/9568307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436332PMC

Methylation at the C-3' in D-Ring of Strigolactone Analogs Reduces Biological Activity in Root Parasitic Plants and Rice.

Front Plant Sci 2019 2;10:353. Epub 2019 Apr 2.

The BioActives Lab, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.

Strigolactones (SLs) regulate plant development and induce seed germination in obligate root parasitic weeds, e.g. spp. Read More

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http://dx.doi.org/10.3389/fpls.2019.00353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455008PMC

Egg Protein Transferrin-Derived Peptides IRW and IQW Regulate -Induced, Inflammation-Related Microbial and Metabolomic Profiles.

Front Microbiol 2019 3;10:643. Epub 2019 Apr 3.

College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China.

Bioactive peptides that target the gastrointestinal tract can strongly affect the health of animals and humans. This study aimed to evaluate the abilities of two peptides derived from egg albumin transferrin, IRW and IQW, to treat enteritis in a mouse model of -induced colitis by evaluating serum metabolomics and gut microbes. Forty-eight mice were randomly assigned to six groups: basal diet (CTRL), intragastric administration (CR), basal diet with 0. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456682PMC

Etiologic and Clinical Features of Cerebral Venous Sinus Thrombosis in Saudi Arabia.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):278-282

Department of Medicine, Division of Neurology, 7-112L Clinical Sciences Building, University of Alberta, Edmonton, Canada.

Objective: Our study aims to evaluate the etiologic and clinical features of cerebral venous sinus thrombosis (CVST) in Saudi Arabia, and secondarily whether gender plays a role in CVST.

Materials And Methods: Data were collected retrospectively from the stroke registry during the period from January 2008 to April 2018, and the patients with the diagnosis of CVST were identified, and data were analyzed for any gender-specific differences in clinical presentation and etiology of cerebral venous thrombosis.

Results: There were 15 females while 11 males with a female:male ratio of 1. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/278/254
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http://dx.doi.org/10.4103/jnrp.jnrp_305_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454937PMC
April 2019
1 Read

Developing Normative Reference Values for Nerve Conduction Studies of Commonly Tested Nerves among a Sample Pakistani Population.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):178-184

Department of Neurophysiology, Aga Khan University Hospital, Karachi, Pakistan.

Introduction: Most neurophysiology departments around the world establish their own normative data. However, ethnic differences are not taken into account. Our aim was to establish normal nerve conduction studies (NCS) data for routinely tested nerves in individuals of Pakistani (South Asian) origin and to compare with Western published data. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_370_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454950PMC

Comparison of Full Outline of UnResponsiveness (FOUR) score and the conventional scores in predicting outcome in aneurysmal subarachnoid haemorrhage patients.

Indian J Anaesth 2019 Apr;63(4):295-299

Department of Anaesthesiology, King Fahad Medical College, Riyadh, Saudi Arabia.

Background And Aims: Full Outline of UnResponsiveness (FOUR) score is a more comprehensive score used to assess eye response, motor response, brainstem reflexes, and respiration that was introduced to overcome the drawbacks of Glasgow coma scale (GCS) score. Our aim was to assess which score best predicts mortality and poor outcome in aneurysmal subarachnoid haemorrhage (aSAH) patients.

Methods: This cohort study, prospectively evaluated the use of FOUR score to assess the mortality and outcome in aSAH patients during the period from November 2015 to November 2016. Read More

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http://dx.doi.org/10.4103/ija.IJA_786_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460986PMC

Comment on Lubna Kanwal Dar et al ( J Pak Med Assoc 2018; 68: 1776-81) Traumatic experiences and dissociation in patients with conversion disorder.

J Pak Med Assoc 2019 Apr;69(4):601

Department of Physical Medicine and Rehabilitation, King Fahad Medical City, Riyadh Saudi Arabia 11525.

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Effect of simulation based education for learning in Medical Students: A mixed study method.

Authors:
Sajida Agha

J Pak Med Assoc 2019 Apr;69(4):545-554

King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

This mixed method study was planned to assess the medical students' experience with simulation-based learning and to identify the issues associated with the application of simulation-based education for experiential learning. Quantitative and qualitative data was collected respectively through a structured questionnaire answered by 145 undergraduate medical students and focus group interviews with six internees who experienced and practised clinical skills with simulators during academic years at King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, between March and April 2017. Although overall respondents were satisfied with simulation-based education, lower satisfaction was identified in areas of available facilities, allocated time for skill labs and debriefing sessions. Read More

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The emerging pathogen Candida auris: A focus on the Middle-Eastern countries.

J Infect Public Health 2019 Apr 15. Epub 2019 Apr 15.

Section Infectious Diseases, Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Recent emergence of Candida auris as a multidrug resistant fungal pathogen, associated with difficult-to-control nosocomial transmission and high mortality, raises serious concerns for public health. Since it was first reported from Japan in 2009, C. auris infections have been diagnosed in several countries from all over the world. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.03.009DOI Listing

Physicochemical characteristics and phytochemical profiles of yellow and red Physalis (Physalis alkekengi L. and P. pubescens L.) fruits cultivated in China.

Food Res Int 2019 Jun 4;120:389-398. Epub 2019 Mar 4.

Institute of Food Science and Biotechnology, University of Hohenheim, 70599 Stuttgart, Germany; Biological Science Department, King Abdulaziz University, P. O. Box 80257, 21589 Jeddah, Saudi Arabia.

Physicochemical characteristics and phytochemical profiles of red (Physalis alkekengi L., RP) and yellow (P. pubescens L. Read More

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http://dx.doi.org/10.1016/j.foodres.2019.03.002DOI Listing

Determination of polycyclic aromatic hydrocarbon content in heat-treated meat retailed in Egypt: Health risk assessment, benzo[a]pyrene induced mutagenicity and oxidative stress in human colon (CaCo-2) cells and protection using rosmarinic and ascorbic acids.

Food Chem 2019 Aug 25;290:114-124. Epub 2019 Mar 25.

Laboratory of Advanced Lipid Analysis, Faculty of Health Sciences, Hokkaido University, Kita 12, Nishi 5, Sapporo 060-0812, Japan. Electronic address:

This study was undertaken to estimate the concentrations of the formed polycyclic aromatic hydrocarbons (PAHs) in heat-treated (boiled, pan-fried and grilled) meats collected from Egypt. Dietary intakes and cancer risks of PAHs among Egyptian adults were calculated. Benzo[a]pyrene (B[a]P)-induced mutagenicity and oxidative stress in human colon (CaCo-2) cell line and mechanisms behind such effects were also investigated. Read More

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http://dx.doi.org/10.1016/j.foodchem.2019.03.127DOI Listing

Identification and Characterization of Salt-Responsive MicroRNAs in by High-Throughput Sequencing.

Genes (Basel) 2019 Apr 17;10(4). Epub 2019 Apr 17.

Botany and Microbiology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Salt stress has detrimental effects on plant growth and development. MicroRNAs (miRNAs) are a class of noncoding RNAs that are involved in post-transcriptional gene expression regulation. In this study, small RNA sequencing was employed to identify the salt stress-responsive miRNAs of the salt-sensitive Hassawi-3 and the salt-tolerant ILB4347 genotypes of faba bean, growing under salt stress. Read More

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https://www.mdpi.com/2073-4425/10/4/303
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http://dx.doi.org/10.3390/genes10040303DOI Listing
April 2019
1 Read

Dynamic Flying Ant Colony Optimization (DFACO) for Solving the Traveling Salesman Problem.

Sensors (Basel) 2019 Apr 17;19(8). Epub 2019 Apr 17.

Department of Computer Science, College of Computer and Information Sciences, King Saud University, Riyadh 11543, Saudi Arabia.

This paper presents an adaptation of the flying ant colony optimization (FACO) algorithm to solve the traveling salesman problem (TSP). This new modification is called dynamic flying ant colony optimization (DFACO). FACO was originally proposed to solve the quality of service (QoS)-aware web service selection problem. Read More

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https://www.mdpi.com/1424-8220/19/8/1837
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http://dx.doi.org/10.3390/s19081837DOI Listing
April 2019
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Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Pharmacognosy Group, Department of Medicinal Chemistry, Biomedical Center (BMC), Uppsala University, SE-751 23 Uppsala, Sweden.

A series of symmetrical salicylaldehyde-bishydrazine azo molecules, -, have been synthesized, characterized by H-NMR and C-NMR, and evaluated for their in vitro α-glucosidase and α-amylase inhibitory activities. All the synthesized compounds efficiently inhibited both enzymes. Compound was the most potent derivative in the series, and powerfully inhibited both α-glucosidase and α-amylase. Read More

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http://dx.doi.org/10.3390/molecules24081511DOI Listing

Regulation of the Expression of DAPK1 by SUMO Pathway.

Biomolecules 2019 Apr 17;9(4). Epub 2019 Apr 17.

Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China.

Death Associated Protein Kinase 1 (DAPK1) is an important signaling kinase mediating the biological effect of multiple natural biomolecules such as IFN-γ, TNF-α, curcumin, etc. DAPK1 is degraded through both ubiquitin-proteasomal and lysosomal degradation pathways. To investigate the crosstalk between these two DAPK1 degradation pathways, we carried out a screen using a set of ubiquitin E2 siRNAs at the presence of Tuberous Sclerous 2 (TSC2) and identified that the small ubiquitin-like molecule (SUMO) pathway is able to regulate the protein levels of DAPK1. Read More

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https://www.mdpi.com/2218-273X/9/4/151
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http://dx.doi.org/10.3390/biom9040151DOI Listing
April 2019
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Quantification of the Transcript Variants in Cancer Cell Lines by Targeted Absolute Quantitative Proteomics and Correlation with mRNA Expression.

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.

proteins have key roles in nuclear structural integrity and chromosomal stability. cumulative protein expression of all variants is reported by semi-quantitative Western blotting. To date, there have not been specific antibodies for the individual transcript variants. Read More

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https://www.mdpi.com/1422-0067/20/8/1902
Publisher Site
http://dx.doi.org/10.3390/ijms20081902DOI Listing
April 2019
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Optimization of Hyperglycemic Induction in Zebrafish and Evaluation of Its Blood Glucose Level and Metabolite Fingerprint Treated with Jack Leaf Extract.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden.

A standard protocol to develop type 1 diabetes in zebrafish is still uncertain due to unpredictable factors. In this study, an optimized protocol was developed and used to evaluate the anti-diabetic activity of leaf. The aims of this study were to develop a type 1 diabetic adult zebrafish model and to evaluate the anti-diabetic activity of the plant extract on the developed model. Read More

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http://dx.doi.org/10.3390/molecules24081506DOI Listing

Formulation of Ethyl Cellulose Microparticles Incorporated Pheophytin A Isolated from for Antioxidant and Cytotoxic Activities.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Department of Pharmaceutics, College of Pharmacy, Qassim University, 51452 Al Qassim, Kingdom of Saudi Arabia.

Background: This study is designed to discover a method for delivering an efficient potent pheophytin a (pheo-a) into more absorbed and small polymeric ethyl cellulose (EC) microparticles.

Methods: Silica gel and Sephadex LH-20 columns were used to isolate pheo-a from the chloroform extract of the edible plant, . Pheo-a was incorporated into EC microparticles using emulsion-solvent techniques. Read More

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http://dx.doi.org/10.3390/molecules24081501DOI Listing

Reconstructions of the dark-energy equation of state and the inflationary potential.

Gen Relativ Gravit 2018 19;50(7):82. Epub 2018 Jun 19.

2Instituto de Ciencias Físicas y Matemáticas, Universidad Austral de Chile, Valdivia, Chile.

We use a mathematical approach based on the constraints systems in order to reconstruct the equation of state and the inflationary potential for the inflaton field from the observed spectral indices for the density perturbations and the tensor to scalar ratio . From the astronomical data, we can observe that the measured values of these two indices lie on a two-dimensional surface. We express these indices in terms of the Hubble slow-roll parameters and we assume that . Read More

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http://dx.doi.org/10.1007/s10714-018-2402-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434992PMC

Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

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http://doi.wiley.com/10.1002/14651858.CD011875.pub2
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http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
April 2019
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UHPLC assisted simultaneous separation of apigenin and prednisolone and its application in the pharmacokinetics of apigenin.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 3;1117:58-65. Epub 2019 Apr 3.

Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P.O. Box: 2457, Saudi Arabia. Electronic address:

A new ultra-high performance liquid chromatography-mass spectrometry-mass spectrometry (UHPLC-MS/MS) system has been formulated for the resolution of closely related drugs apigenin (API, a bioflavinoid) and prednisolone (PRD) from their mixture. This developed method comprised of a "BEH™ C column (50 mm × 2.1 mm, 1. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.006DOI Listing

Belizatinib: Novel reactive intermediates and bioactivation pathways characterized by LC-MS/MS.

J Pharm Biomed Anal 2019 Apr 6;171:132-147. Epub 2019 Apr 6.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt. Electronic address:

Belizatinib (BZB; TSR-011) is a next-generation anaplastic lymphoma kinase inhibitor that also inhibits tropomyosin-related kinases A/B/C. In this in-vitro study, we examined the formation of reactive metabolites from BZB using rat liver microsomes or human liver microsomes in the presence of a trapping agent (potassium cyanide) to generate iminium reactive intermediates. Identification of the in vitro BZB metabolites indicated that the major in-vitro metabolic reaction involved hydroxylation of the piperidine moiety. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07317085193001
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http://dx.doi.org/10.1016/j.jpba.2019.04.006DOI Listing
April 2019
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Experimental and theoretical insights on the effect of solvent polarity on the photophysical properties of a benzanthrone dye.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 3;218:221-228. Epub 2019 Apr 3.

Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.

Benzanthrone derivatives show interesting solvent dependent photophysical properties. Understanding of their photophysical properties is essential for developing the fluorescence probes based on benzanthrone derivatives. The photophysical properties of 3-(N'-chlorophenyl)piperazino-7H-benzo[de]anthracen-7-one [ClPh-PBA] molecule are reported in different solvents and solvent mixtures. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.001DOI Listing

Wettability of rock/CO/brine and rock/oil/CO-enriched-brine systems:Critical parametric analysis and future outlook.

Adv Colloid Interface Sci 2019 Apr 1;268:91-113. Epub 2019 Apr 1.

School of Engineering, Edith Cowan University (ECU), Joondalup, WA, Australia.

CO geo-sequestration is a promising technology to permanently store CO in geological formations to control the atmospheric carbon footprint. In addition, CO is frequently utilized in enhanced oil recovery operations to accelerate oil production. Both, CO geo-storage and EOR, are significantly influenced by the wettability of the associated rock/CO/brine systems. Read More

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http://dx.doi.org/10.1016/j.cis.2019.03.009DOI Listing

Radical chest wall resection and modified reconstruction technique for solitary internal mammary lymph node recurrence in breast cancer.

Int J Surg Case Rep 2019 Apr 6;58:26-29. Epub 2019 Apr 6.

Department of Thoracic Surgery and Oncology, King Fahad Specialist Hospital Dammam, Saudi Arabia.

Introduction: Although the incidence of internal mammary lymph node recurrence rate in breast cancer is low but still it is the second most common drainage site after axilla. Patients with solitary internal mammary lymph node (IMLN) recurrence have overall better prognosis. The role of chemo and radiotherapy in internal mammary lymph node involvement with breast cancer is still controversial. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.021DOI Listing

Post-irradiation recovery time strongly influences fractional laser-facilitated skin absorption.

Int J Pharm 2019 Apr 15. Epub 2019 Apr 15.

Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan; Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan. Electronic address:

Fractional CO laser treatment has been used in some clinical trials to promote topical drug delivery. Currently, there is no standard for laser settings to achieve a feasible therapy. The cutaneous recovery following laser treatment and its influence on drug absorption have not been well explored. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193030
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http://dx.doi.org/10.1016/j.ijpharm.2019.04.043DOI Listing
April 2019
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Are the ecological effects of the "worst" marine invasive species linked with scientific and media attention?

PLoS One 2019 18;14(4):e0215691. Epub 2019 Apr 18.

Red Sea Research Center (RSRC) and Computational Biosciences Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.

Non-native species are a major driver of environmental change. In this study we assessed the ecological impact of the "worst" non-native species and the associated scientific and media publications through time to understand what influences interest in these species. Ecological effect was based on a qualitative assessment reported in research publications and additional searches of the scientific and media attention were conducted to determine published articles and assess attention. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215691PLOS

TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.

PLoS Pathog 2019 Apr 18;15(4):e1007657. Epub 2019 Apr 18.

Biomedical and Life Sciences, Faculty of Health and Medicine, University of Lancaster, Lancaster, United Kingdom.

Helminths are highly prevalent metazoan parasites that infect over a billion of the world's population. Hosts have evolved numerous mechanisms to drive the expulsion of these parasites via Th2-driven immunity, but these responses must be tightly controlled to prevent equally devastating immunopathology. However, mechanisms that regulate this balance are still unclear. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007657DOI Listing

No differences in effectiveness and safety between pipeline embolization device and stent-assisted coiling for the treatment of communicating segment internal carotid artery aneurysms.

Neuroradiol J 2019 Apr 18:1971400919845368. Epub 2019 Apr 18.

1 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Background: Aneurysms arising from the communicating segment (C7) of the internal carotid artery (ICA) are one of the most frequent locations of intracranial aneurysms. Stent-assisted coiling (SAC) and flow diversion therapies are both endovascular strategies used for the treatment of ICA aneurysms occurring at the C7 segment.

Objective: The aim of this study is to compare both methods' angiographic and functional outcomes, and procedural complications. Read More

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http://dx.doi.org/10.1177/1971400919845368DOI Listing

Heat transfer enhancement in the boundary layer flow of hybrid nanofluids due to variable viscosity and natural convection.

Heliyon 2019 Apr 4;5(4):e01469. Epub 2019 Apr 4.

Department of Studies and Research in Mathematics, Kuvempu University, Shankaraghatta, 577 451, Shimoga, Karnataka, India.

The aim of the current work is to explore how heat transfer can be enhanced by variations in the basic properties of fluids in the presence of free convection with the aid of suspended hybrid nanofluids. Also, the influence of the Laurentz force on the flow is considered. The mathematical equations are converted into a pair of self-similarity equations by applying appropriate transformations. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451174PMC

Reducing hospital-acquired pressure injuries.

BMJ Open Qual 2019 13;8(1):e000464. Epub 2019 Feb 13.

General Department of Medical Services, Quality & Patient Safety, Riyadh, Saudi Arabia.

Hospital-acquired pressure injury is a common preventable condition. Our hospital is a 144-bed governmental hospital in the Kingdom of Saudi Arabia that was found to have a 7.5% prevalence of hospital-acquired pressure injury in 2016. Read More

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http://qir.bmj.com/lookup/doi/10.1136/bmjoq-2018-000464
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http://dx.doi.org/10.1136/bmjoq-2018-000464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440606PMC
February 2019
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