74,482 results match your criteria Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation Saudi Arabia[Journal]


A comparison of gravity-driven membrane (GDM) reactor and biofiltration + GDM reactor for seawater reverse osmosis desalination pretreatment.

Water Res 2019 Feb 4;154:72-83. Epub 2019 Feb 4.

Singapore Membrane Technology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, Singapore 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 639798, Singapore. Electronic address:

In this study, permeate quality, membrane performance, and microbial community in a gravity-driven microfiltration (GDM) reactor and a biofiltration (BF) + GDM reactor for seawater reverse osmosis (RO) desalination pretreatment were compared at both lab-scale and pilot-scale. The presence of BF column was more efficient in removing soluble organic substances by biosorption/biodegradation, leading to superior permeate quality from BF + GDM and subsequently lower RO fouling than GDM. Compared to the biofilm-saturated anthracite media, the granular activated carbon media in BF improved the assimilable organic substances removal in BF + GDM. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.044DOI Listing
February 2019

Exploration of the adsorption performance and mechanism of zeolitic imidazolate framework-8@graphene oxide for Pb(II) and 1-naphthylamine from aqueous solution.

J Colloid Interface Sci 2019 Feb 11;542:410-420. Epub 2019 Feb 11.

CAS Key Laboratory of Photovoltaic and Energy Conservation Materials, Institute of Plasma Physics, Chinese Academy of Sciences, P.O. Box 1126, Hefei 230031, PR China; NAAM Research Group, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address:

A novel composite of zeolitic imidazolate framework grown on graphene oxide (ZIF-8@GO) was successfully prepared and used for the adsorption of Pb(II) and 1-naphthylamine from aqueous solutions. The effects of contact time, pH, ionic strength and temperature on the adsorption performance of ZIF-8@GO was investigated by batch experiments. Compared to the bare ZIF-8 and GO, the ZIF-8@GO exhibited a significant increase in the adsorption for Pb(II) and 1-naphthylamine. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.02.039DOI Listing
February 2019

Laparoscopic removal of gastric balloon after failure of endoscopic retrieval.

Int J Surg Case Rep 2019 Feb 10;55:210-212. Epub 2019 Feb 10.

Department of Surgery, King Fahd Hospital of The University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. Electronic address:

Introduction: Different therapeutic measures have been developed in the treatment of obesity. Gastric balloon is a minimally-invasive modality in obesity treatment, but it is not without a risk of complications.

Presentation Of Case: We present a 44-year-old morbidly obese lady who underwent gastric balloon insertion and refused to remove it at the recommended time. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.043DOI Listing
February 2019

Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.

Eur J Med Chem 2019 Feb 8;167:161-186. Epub 2019 Feb 8.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. Electronic address:

Neuroinflammation and cholinergic deficit are key detrimental processes involved in Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the multi-target-directed ligand paradigm was applied to the rational design of two series of new hybrids endowed with anti-inflammatory and anticholinesterase activity via triple targeting properties, namely able to simultaneously hit cholinesterases, cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX) enzymes. Among the synthesized compounds, triazoles 5b and 5d, and thiosemicarbazide hybrid 6e emerged as promising new hits, being able to effectively inhibit human butyrylcholinesterase (hBChE), COX-2 and 15-LOX enzymes with a higher inhibitory potency than the reference inhibitors tacrine (for hBChE inhibition), celecoxib (for COX-2 inhibition) and both NDGA and Zileuton (for 15-LOX inhibition). Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.012DOI Listing
February 2019

Evaluation of Radiological Features of the Posterior Communicating Artery and their Impact on Efficacy of Saccular Aneurysm Treatment with the Pipeline Embolization Device: A Case Series Study.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; Department of Neurosurgery, The National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia. Electronic address:

Background And Purpose: Posterior communicating artery segment aneurysms are one of the most frequent intracranial aneurysms. Currently, there is limited literature describing the use of the pipeline embolization device in these aneurysms.

Material And Methods: We conducted a multicenter retrospective review of 3 prospectively-collected databases of patients treated with pipeline between January 2013 and December 2017. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.228DOI Listing
February 2019

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Ethnopharmacological Relevance: Ribes alpestre Decne has been commonly used in the treatment of joint complaints.

Aim Of Study: The present study was undertaken to evaluate the antiarthritic potential of ethanolic extract and fractions of Ribes alpestre and to explore its probable mechanism of action.

Material And Methods: Complete Freunds adjuvant induced arthritis in Sprague Dawley rats was used to assess antiarthritic activity of aqueous ethanol extract, butanol and aqueous fractions at 200mg/kg oral dose for 28 days. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.025DOI Listing
February 2019

Perceptions of Canadian vascular surgeons toward pharmacologic risk reduction in patients with peripheral artery disease: 2018 update.

Ann Vasc Surg 2019 Feb 13. Epub 2019 Feb 13.

Division of Vascular Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, and University of Toronto, Toronto, ON, Canada; Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia; King Saud University-Li Ka Shing Collaborative Research Program, Toronto, Ontario, Canada; and Riyadh, Kingdom of Saudi Arabia. Electronic address:

Background: Vascular surgeons have a central role in managing peripheral artery disease (PAD). This study assessed their knowledge, attitudes, and behaviours regarding pharmacologic risk reduction in PAD and results were compared to a similar 2004 survey conducted by our group.

Methods: An online questionnaire was administered to 161 active members of the Canadian Society for Vascular Surgery. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.034DOI Listing
February 2019

Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt disease using en face OCT and OCT Angiography.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Casey Eye Institute, Oregon Health & Science University, Portland, OR, United States. Electronic address:

Purpose: Measure and correlate degeneration of the inner segment/outer segment junction (IS/OS), retinal pigment epithelium (RPE) and choriocapillaris (CC) in Stargardt disease (STGD) DESIGN: Prospective cross-sectional study METHODS SETTING: Casey Eye Institute POPULATION: 23 patients with STGD PROCEDURES: OCT angiography (OCTA) scans were centered on the fovea. OCT slab projection and en face boundary maps were used to create masks to measure total IS/OS loss or RPE atrophy, as well as regions of isolated IS/OS loss, isolated RPE atrophy, matched IS/OS and RPE degeneration, or intact IS/OS and RPE. CC vascular density (CCVD) was quantified from CC angiogram. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.007DOI Listing
February 2019

Diagnostic reference levels for F-FDG whole body PET/CT procedures: Results from a survey of 12 centres in Australia and New Zealand.

J Med Imaging Radiat Oncol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Health Sciences, Discipline of Medical Radiation Science, The University of Sydney, Sydney, New South Wales, Australia.

Introduction: The aim of this work is to report diagnostic reference levels (DRLs) for hybrid positron emission tomography and x-ray computed tomography (PET/CT) exams in Australia (AU) for Queensland (QLD) and Western Australia (WA) (AU QLD/WA) and New Zealand (NZ).

Methods: Two-structured booklets were designed to collect dose information, patient demographics, equipment details and acquisition protocols for fluoride-18 fluorodeoxyglucose ( F-FDG) PET/CT procedures, and any additional diagnostic CT routinely performed as part of F-FDG whole-body examination. The DRL was reported based on the 75 percentile and achievable dose for F-FDG, CT dose index volume (CTDI ) and dose length product (DLP). Read More

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http://dx.doi.org/10.1111/1754-9485.12857DOI Listing
February 2019

Dearomatization of 3-Nitroindoles via a Phosphine-catalyzed Enantioselective [3+2] Annulation Reaction.

Angew Chem Int Ed Engl 2019 Feb 15. Epub 2019 Feb 15.

SAUDI ARABIA.

A dearomatization process of 3-nitroindoles via a chiral phosphine-mediated [3+2] annulation reaction has been developed. This method makes use of readily available 3-nitroindoles as an aromatic feedstock and quickly delivers a wide range of cyclopentaindoline alkaloid scaffolds in a highly enantioselective manner. Notably, this is the first time that phosphine-triggered cyclization has been utilized in a dearomatization process. Read More

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http://dx.doi.org/10.1002/anie.201900248DOI Listing
February 2019

Iron oxide nanoparticles based antiviral activity of H1N1 influenza A virus.

J Infect Chemother 2019 Feb 12. Epub 2019 Feb 12.

Molecular Biology Department, Rajendra Memorial Research Institute of Medical Sciences (ICMR), Patna, India. Electronic address:

Influenza virus is a common human pathogenic agent that has caused serious respiratory illness and death over the past century and in recent year. Treatment options against pandemic influenza strain A/H1N1 are very limited and unsatisfactory. Therefore we have developed iron oxide nanoparticles (IO-NPs) with particle size in the range of 10-15 nm against pandemic influenza strain A/H1N1/Eastern India/66/PR8-H1N1. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.12.006DOI Listing
February 2019

Overexpression of Transcription Factor Enhances Drought Stress Tolerance in Cotton ( L.).

Genes (Basel) 2019 Feb 14;10(2). Epub 2019 Feb 14.

Biological Sciences Department, Faculty of Science, University of Jeddah, Jeddah 21577, Saudi Arabia.

Drought stress significantly restricts plant growth and crop productivity. Cotton is the most important textile fiber and oilseed crop worldwide, and its cultivation is affected by drought stress, particularly in dry regions. Improving cotton tolerance to drought stress using the advanced genetic engineering technologies is a promising strategy to maintain crop production and fiber quality and meet the increasing worldwide fiber and oil demand. Read More

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http://dx.doi.org/10.3390/genes10020142DOI Listing
February 2019

High-Throughput Virtual Screening, Molecular Dynamics Simulation, and Enzyme Kinetics Identified ZINC84525623 as a Potential Inhibitor of NDM-1.

Int J Mol Sci 2019 Feb 14;20(4). Epub 2019 Feb 14.

Program in Translational Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.

The bacteria expressing New Delhi Metallo-β-lactamase-1 (NDM-1) can hydrolyze all β-lactam antibiotics including carbapenems, causing multi-drug resistance. The worldwide emergence and dissemination of gene (produces NDM-1) in hospital and community settings, rising problems for public health. Indeed, there is an urgent need for NDM-1 inhibitors to manage antibiotic resistance. Read More

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http://dx.doi.org/10.3390/ijms20040819DOI Listing
February 2019
2.862 Impact Factor

Bioactivity Profile of the Diterpene Isosteviol and its Derivatives.

Molecules 2019 Feb 14;24(4). Epub 2019 Feb 14.

Department of Chemistry, Islamia College University Peshawar, Peshawar 25120, Pakistan.

Steviosides, rebaudiosides and their analogues constitute a major class of naturally occurring biologically active diterpene compounds. The wide spectrum of pharmacological activity of this group of compounds has developed an interest among medicinal chemists to synthesize, purify, and analyze more selective and potent isosteviol derivatives. It has potential biological applications and improves the field of medicinal chemistry by designing novel drugs with the ability to cope against resistance developing diseases. Read More

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http://dx.doi.org/10.3390/molecules24040678DOI Listing
February 2019

Rapid Growth of TiO₂ Nanoflowers via Low-Temperature Solution Process: Photovoltaic and Sensing Applications.

Materials (Basel) 2019 Feb 14;12(4). Epub 2019 Feb 14.

Department of Physics, Faculty of Science, King Khalid University; P.O. Box 9004, Abha 61421, Saudi Arabia.

This paper reports the rapid synthesis, characterization, and photovoltaic and sensing applications of TiO₂ nanoflowers prepared by a facile low-temperature solution process. The morphological characterizations clearly reveal the high-density growth of a three-dimensional flower-shaped structure composed of small petal-like rods. The detailed properties confirmed that the synthesized nanoflowers exhibited high crystallinity with anatase phase and possessed an energy bandgap of 3. Read More

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http://dx.doi.org/10.3390/ma12040566DOI Listing
February 2019

Examining the Walking Accessibility, Willingness, and Travel Conditions of Residents in Saudi Cities.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

School of Engineering, The University of British Columbia (UBC)-Okanagan, 1137 Alumni Ave, Kelowna 1V1 1V7, BC, Canada.

Rapid urban expansion and population growth in Saudi cities over the past four decades have increased vehicular accidents and traffic congestion and have impacted the daily walking conditions of the residents. Walking has various health and environmental benefits. In North American and European countries, three factors have been found to motivate a resident to walk within their community: their accessibility to community social and business facilities, their perception and willingness, and the safety conditions of the roads and sidewalks within their community for walking. Read More

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http://dx.doi.org/10.3390/ijerph16040545DOI Listing
February 2019

Non-Toxic and Ultra-Small Biosilver Nanoclusters Trigger Apoptotic Cell Death in Fluconazole-Resistant via Ras Signaling.

Biomolecules 2019 Jan 29;9(2). Epub 2019 Jan 29.

Herbal Nanobiotechnology Lab, Pharmacology Division, CSIR-National Botanical Research Institute, Lucknow 226001, India.

Silver-based nanostructures are suitable for many biomedical applications, but to be useful therapeutic agents, the high toxicity of these nanomaterials must be eliminated. Here, we biosynthesize nontoxic and ultra-small silver nanoclusters (rsAg@NCs) using metabolites of usnioid lichen (a symbiotic association of algae and fungi) that exhibit excellent antimicrobial activity against fluconazole (FCZ)-resistant that is many times higher than chemically synthesized silver nanoparticles (AgNPs) and FCZ. The rsAg@NCs trigger apoptosis via reactive oxygen species accumulation that leads to the loss of mitochondrial membrane potential, DNA fragmentation, chromosomal condensation, and the activation of metacaspases. Read More

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http://dx.doi.org/10.3390/biom9020047DOI Listing
January 2019

Ectopic intranasal canine tooth in a child: A rare case report and literature review.

Int J Surg Case Rep 2019 Jan 31;55:202-205. Epub 2019 Jan 31.

Department of Otolaryngology, King Fahad Specialty Hospital, Dammam, Saudi Arabia. Electronic address:

Introduction: Intranasal teeth are a rare form of ectopic teeth. Their clinical manifestation are truly variable. In children, intranasal teeth are typically associated with cleft lip and alveolus. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.037DOI Listing
January 2019

Comparative study between two red algae for biosynthesis silver nanoparticles capping by SDS: Insights of characterization and antibacterial activity.

Microb Pathog 2019 Feb 12. Epub 2019 Feb 12.

Department of Microbial Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Egypt.

Biosynthesis silver nanoparticles (AgNPs) have received a lot of attention as a Cytotoxic and antimicrobial activity against pathogenic bacteria. This study was carried out to evaluate the potential ability of red marine algae Corallina elongata and Gelidium amansii to biosynthesis AgNPs capping with Sodium Dodecyl Sulfate (SDS) and to determine its antibacterial efficacy. Characterization of capping AgNPs were determined by Ultra violet-Visible spectroscopy, Transmission electron microscope (TEM), Scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FTIR), Energy dispersive X-ray spectroscopy (EDX), Zeta potential and sizer. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.016DOI Listing
February 2019

Site-directed chemically-modified magnetic enzymes: fabrication, improvements, biotechnological applications and future prospects.

Biotechnol Adv 2019 Feb 12. Epub 2019 Feb 12.

Life Sciences Department, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia. Electronic address:

Numerous enzymes of biotechnological importance have been immobilized on magnetic nanoparticles (MNP) via random multipoint attachment, resulting in a heterogeneous protein population with potential reduction in activity due to restriction of substrate access to the active site. Several chemistries are now available, where the modifier can be linked to a single specific amino acid in a protein molecule away from the active-site, thus enabling free access of the substrate. However, rarely these site-selective approaches have been applied to immobilize enzymes on nanoparticles. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.002DOI Listing
February 2019

Feature enhancement framework for brain tumor segmentation and classification.

Microsc Res Tech 2019 Feb 15. Epub 2019 Feb 15.

Department of Computer Science, University of Engineering and Technology, Taxila, Pakistan.

Automatic medical image analysis is one of the key tasks being used by the medical community for disease diagnosis and treatment planning. Statistical methods are the major algorithms used and consist of few steps including preprocessing, feature extraction, segmentation, and classification. Performance of such statistical methods is an important factor for their successful adaptation. Read More

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http://dx.doi.org/10.1002/jemt.23224DOI Listing
February 2019

Construction of saliency map and hybrid set of features for efficient segmentation and classification of skin lesion.

Microsc Res Tech 2019 Feb 15. Epub 2019 Feb 15.

Department of Information Systems, Al Yamamah University, Riyadh, KSA.

Skin cancer is being a most deadly type of cancers which have grown extensively worldwide from the last decade. For an accurate detection and classification of melanoma, several measures should be considered which include, contrast stretching, irregularity measurement, selection of most optimal features, and so forth. A poor contrast of lesion affects the segmentation accuracy and also increases classification error. Read More

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http://dx.doi.org/10.1002/jemt.23220DOI Listing
February 2019

Conformation-Controlled Molecular Sieving Effects for Membrane-Based Propylene/Propane Separation.

Adv Mater 2019 Feb 15:e1807513. Epub 2019 Feb 15.

School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332-0100, USA.

Membrane-based separation is poised to reduce the operation cost of propylene/propane separation; however, identifying a suitable molecular sieve for membrane development is still an ongoing challenge. Here, the successful identification and use of a metal-organic framework (MOF) material as fillers, namely, the Zr-fum-fcu-MOF possessing an optimal contracted triangular pore-aperture driving the efficient diffusive separation of propylene from propane in mixed-matrix membranes are reported. It is demonstrated that the fabricated hybrid membranes display a high propylene/propane separation performance, far beyond the current trade-off limit of polymer membranes with excellent properties under industrial conditions. Read More

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http://dx.doi.org/10.1002/adma.201807513DOI Listing
February 2019

Improving pediatric emergency department physicians' adherence to clinical practice guidelines on the diagnosis and management of group A beta-hemolytic streptococcal pharyngitis-a cross-sectional study.

Int J Emerg Med 2018 16;11:49. Epub 2018 Nov 16.

4Department of Pediatric Emergency, College of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAUHS), Riyadh, Saudi Arabia.

Introduction: Pharyngitis is one of the major and commonly seen presentations in pediatric emergency departments. While it could be caused by both bacterial and viral pathogens, antibiotics are improperly prescribed regardless of the pathogen. Inappropriate usage of antibiotics has risen the concern of microbial resistance and the need for stricter guidelines. Read More

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http://dx.doi.org/10.1186/s12245-018-0209-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326116PMC
November 2018

The rs61742690 (S783N) single nucleotide polymorphism is a suitable target for disrupting BCL11A-mediated foetal-to-adult globin switching.

PLoS One 2019 15;14(2):e0212492. Epub 2019 Feb 15.

Department of Genetic Research, Institute for Research and Medical Consultation (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Background: B-cell lymphoma/leukaemia 11A (BCL11A) is a C2H2-type zinc-finger transcription factor protein that is a critical modulator of haemoglobin switching and suppresses the production of foetal haemoglobin. Variation in the BCL11A gene ameliorates the severity of sickle cell disease (SCD) and β-thalassemia (β-thal). The BCL11A gene is located on chromosome 2p16. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212492PLOS
February 2019

Association Between Self-rated Health, Coronary Artery Calcium Scores, and Atherosclerotic Cardiovascular Disease Risk: The Multi-Ethnic Study of Atherosclerosis (MESA).

JAMA Netw Open 2019 Feb 1;2(2):e188023. Epub 2019 Feb 1.

Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, Maryland.

Importance: The interplay of self-rated health (SRH), coronary artery calcium (CAC) scores, and cardiovascular risk is poorly described.

Objectives: To assess the degree of correlation between SRH and CAC, to determine whether these measures are complementary for risk prediction, and to assess the incremental value of the addition of SRH to established risk tools.

Design, Setting, And Participants: The Multi-Ethnic Study of Atherosclerosis (MESA) is a large population-based prospective cohort study of adults aged 45 to 84 years who were recruited from 6 US communities. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.8023DOI Listing
February 2019

Enhancing charge transport in an organic photoactive layer via vertical component engineering for efficient perovskite/organic integrated solar cells.

Nanoscale 2019 Feb 15. Epub 2019 Feb 15.

State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources, North China Electric Power University, Beijing 102206, China. and Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

Suitable vertical component distribution within an organic bulk-heterojunction (BHJ) is vital for effective exciton dissociation and smooth charge transport in perovskite/organic integrated solar cells (ISCs). Herein, a bi-continuous interpenetrating network of organic donor/acceptor materials is constructed simply by optimizing their weight ratio, and is further applied in perovskite/organic ISCs. Time-of-flight secondary-ion mass spectroscopy (TOF-SIMS) and scanning Kelvin probe microscopy (SKPM) strongly confirm that this method can effectively restrict vertical stratification and build a desired bi-continuous framework within the organic photoactive layer, which can effectively suppress two potential recombination losses from the viewpoint of kinetics, leading to the PCE increasing from 12. Read More

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http://dx.doi.org/10.1039/c8nr09467eDOI Listing
February 2019

EEG of asymptomatic first-degree relatives of patients with juvenile myoclonic, childhood absence and rolandic epilepsy: a systematic review and meta-analysis.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Institute of Medical Science, University of Toronto, Toronto, Division of Neurology, Department of Pediatrics, University of Texas Southwestern, Dallas, USA.

Rolandic (RE), childhood absence (CAE) and juvenile myoclonic (JME) epilepsy encompass centrotemporal sharp waves, 3-Hz spike waves and >3-Hz spike or polyspike waves, respectively. Evidence abounds for genetic roles in all three syndromes, yet involved genes for the vast majority of patients remain unknown. It has long been proposed that while each disease is genetically complex, its specific EEG trait may represent a genetically simpler endophenotype. Read More

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http://dx.doi.org/10.1684/epd.2019.1024DOI Listing
February 2019

Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents.

J Ovarian Res 2019 Feb 15;12(1):18. Epub 2019 Feb 15.

The Division of Cancer Biology and Biologic Therapeutics Center, Department of Radiation Oncology, School of Medicine, Washington University in Saint Louis, 660 South Euclid Avenue, Campus Box 8224, St. Louis, MO, 63110, USA.

Background: Virotherapy represents a promising approach for ovarian cancer. In this regard, conditionally replicative adenovirus (CRAd) has been translated to the context of human clinical trials. Advanced design of CRAds has sought to exploit their capacity to induce anti-tumor immunization by configuring immunoregulatory molecule within the CRAd genome. Read More

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http://dx.doi.org/10.1186/s13048-019-0493-5DOI Listing
February 2019

Clinical Predictors of Diabetic Retinopathy Progression; A Systematic Review.

Curr Diabetes Rev 2019 Feb 15. Epub 2019 Feb 15.

Department of Ophthalmology, Faculty of Medicine, Taif University, Taif. Saudi Arabia.

Objective: The study aims to review the published clinical predictors of Diabetic Retinopathy Progression and discuss their level of clinical significance.

Methods: The data for systematic review has been gathered from the studies that were searched through scholarly platforms and several libraries. These studies discussed the clinical predictors of Diabetic Retinopathy (DR) progression. Read More

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http://dx.doi.org/10.2174/1573399815666190215120435DOI Listing
February 2019

3D Printing In Personalized Drug Delivery.

Curr Pharm Des 2019 Feb 15. Epub 2019 Feb 15.

Centre of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi. India.

Background: Personalized medicines are becoming more popular as they enables the use of patient's genomics and hence help in better drug design with fewer side effects. In fact several doses can be combined into one dosage form which suits the patient's demography. 3 Dimensional (3D) printing technology for personalized medicine is a modern day treatment method based on genomics of patient. Read More

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http://dx.doi.org/10.2174/1381612825666190215122208DOI Listing
February 2019

Proteomic Changes in Oral Keratinocytes Chronically Exposed to Shisha (Water Pipe).

OMICS 2019 Feb;23(2):86-97

1 Department of Medical Biotechnologies, School of Dental Medicine, University of Siena, Siena, Italy.

Shisha (water pipe) smoking is falsely believed to be a hazard-free habit and has become a major public health concern. Studies have reported shisha smoking to be associated with oral lesions, as well as carcinomas of the lung, esophagus, bladder, and pancreas. A deeper understanding of the underlying molecular mechanisms would contribute to identification of biomarkers for targeted public health screening, therapeutic innovation, and better prognosis of associated diseases. Read More

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http://dx.doi.org/10.1089/omi.2018.0173DOI Listing
February 2019

Description and Initial Experience with the "LIFT" (Less Incisions but Four Trocars) Technique for Laparoscopic Cholecystectomy.

J Laparoendosc Adv Surg Tech A 2019 Feb 15. Epub 2019 Feb 15.

1 Sulaiman AlHabib Medical Group, Department of General Surgery, Al-Takhassusi General Hospital, Riad, Saudi Arabia.

Background: Modifications to conventional laparoscopic cholecystectomy (LC) aim to reduce trauma to the abdominal wall and improve cosmetic outcomes. Although single-incision laparoscopic surgery (SILS) provides excellent cosmetic results, the procedure is technically demanding. Herein, we describe the LIFT technique ("Less Incisions but Four Trocars"), with four trocars but only one 3-mm visible incision, using conventional instruments. Read More

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http://dx.doi.org/10.1089/lap.2018.0785DOI Listing
February 2019

Fat mass and obesity-associated (FTO) and leptin receptor (LEPR) gene polymorphisms in Egyptian obese subjects.

Arch Physiol Biochem 2019 Feb 15:1-9. Epub 2019 Feb 15.

c Genetic Unit, Children Hospital , Mansoura University , Mansoura , Egypt.

Background: Several studies addressed the contribution of fat mass and obesity-associated (FTO) and leptin receptor (LEPR) polymorphisms for the susceptibility to obesity among different ethnic subjects. The main purpose of this work is to evaluate the association of these polymorph\isms with obesity among Egyptian subjects.

Subjects And Methods: This case-control study was carried out on 110 unrelated obese Egyptian subjects who were compared with 122 controls. Read More

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http://dx.doi.org/10.1080/13813455.2019.1573841DOI Listing
February 2019

Clinical and radiographic peri-implant health status around narrow diameter implant-supported single and splinted crowns.

Clin Implant Dent Relat Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.

Background: Studies assessing and comparing clinical and radiographic peri-implant status around narrow diameter implant-supported single crowns (NDISCs) and splinted crowns (NDISPs) are scarce.

Objective: The aim of this retrospective study was to estimate and compare complication rates, patient satisfaction, peri-implant status and peri-implant bone loss (PBL) of NDISCs and NDISPs.

Materials And Methods: Patients receiving narrow diameter implants (NDIs) in the posterior mandible were assessed. Read More

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http://dx.doi.org/10.1111/cid.12718DOI Listing
February 2019

Delayed spontaneous closure of blue laser-induced full thickness macular hole.

Am J Ophthalmol Case Rep 2019 Mar 9;13:154-156. Epub 2019 Jan 9.

Lebanese American University, Beirut, Lebanon.

Purpose: To report a blue laser-induced full thickness macular hole (FTMH) with delayed spontaneous closure without surgical intervention.

Observations: A 14-year old male developed full thickness macular hole after momentary exposure to a high-power handheld blue laser device. The macular hole closed spontaneously over a long period of observation. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351355PMC

Exercise capacity and muscle fatiguability alterations following a progressive maximal exercise of lower extremities in children with cystic fibrosis.

Afr Health Sci 2018 Dec;18(4):1236-1242

Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.

Background: Impairment of peripheral skeletal muscle function is a common phenomenon in patients with cystic fibrosis (CF) in addition to great clinical connotations, such as lack of exercise tolerance and decrease of health-related quality of life. There is very limited data on the effects of maximal exercise on muscle fatiguability and exercise capacity in children with cystic fibrosis.

Objectives: The aim of this study was to evaluate the effect of progressive maximal exercise training of the lower extremities on exercise capacity and muscle fatiguability in children with cystic fibrosis. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354874PMC
December 2018

Interferon-γ receptor-1 gene promoter polymorphisms and susceptibility for brucellosis in Makkah region.

Afr Health Sci 2018 Dec;18(4):1157-1165

Department of Medical Microbiology, Faculty of Applied Medical Sciences, Taif University, Turabah, 21995, KSA.

Background: Genetic polymorphisms that affect the production levels of certain cytokines and/or their receptors may determine the risk, severity or protection in some infectious diseases like brucellosis.

Objectives: The aim of this study was to investigate the association of certain known Interferon-γ Receptor-1 (IFN-γ R1) gene promoter polymorphisms and the susceptibility to infection with Brucellosis in Saudi population.

Methods: A cases-control association study was conducted in 69 individuals with human brucellosis and 94 healthy individuals. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354847PMC
December 2018

Impact of weight reduction on insulin resistance, adhesive molecules and adipokines dysregulation among obese type 2 diabetic patients.

Afr Health Sci 2018 Dec;18(4):873-883

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: Type 2 diabetes mellitus is usually related to vascular problems and is associated with impairment in endothelial function characterized by impaired endothelial-dependent vasodilation and increased platelet adhesion. There is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of endothelial dysfunction and adipokines dysregulation for obesity associated with type 2 diabetes mellitus.

Objective: This study was designed to detect the effects of weight loss on insulin resistance, adhesive molecules and adipokines dysregulation in obese type 2 diabetic patients. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354881PMC
December 2018

Molecular pathways of oral cancer that predict prognosis and survival: A systematic review.

J Carcinog 2018 31;17. Epub 2018 Dec 31.

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.

Several genes and pathways associated with oral squamous cell carcinoma (OSCC) are significant in terms of early detection and prognosis. The objective of this literature review is to evaluate the current research on molecular pathways and genes involved in oral cancer. Articles on the genes involved in oral cancer pathways were evaluated to identify potential biomarkers that can predict survival. Read More

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http://dx.doi.org/10.4103/jcar.JCar_17_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334533PMC
December 2018

Employing a PLGA-TPGS based nanoparticle to improve the ocular delivery of Acyclovir.

Saudi Pharm J 2019 Feb 23;27(2):293-302. Epub 2018 Nov 23.

Nanobiotechnology Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Delivering drugs via the ocular route has always been a challenge for poorly soluble drugs. The various anatomical and physiological barriers in the eye cavity hinder the residence of drugs within the corneal and precorneal regions. In this study, the nanosystem that could sufficiently deliver the poorly soluble Acyclovir topically via ocular route. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362158PMC
February 2019

Antibacterial activity of biosynthesized gold nanoparticles using biomolecules from and chitosan.

Saudi Pharm J 2019 Feb 23;27(2):283-292. Epub 2018 Nov 23.

Tissue Engineering Centre, UKM Medical Centre, 56000, Cheras, Kuala Lumpur, Malaysia.

A simple, cost-effective, and environmentally friendly method is needed for synthesizing metal nanoparticles, including gold nanoparticles (AuNPs). In this study, AuNPs were synthesized with sclerotial extract (LRE) and chitosan (CS) as reducing and stabilizing agents, respectively. Different LRE concentrations from cold and hot water extraction (CWE and HWE, respectively) were used to reduce chloroauric acid (HAuCl) to form AuNPs. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362174PMC
February 2019

Students perception of an industry based approach problem based learning (PBL) and their performance in drug delivery courses.

Saudi Pharm J 2019 Feb 20;27(2):274-282. Epub 2018 Nov 20.

Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi Mara, Puncak Alam Campus, 42300 Selangor, Malaysia.

Objective: To investigate students perception of an industry based approach problem based learning (PBL) and their performance in drug delivery courses in pharmaceutics.

Methods: PBL was implemented within two drug delivery courses in 2015, in anticipation that the use of formulation or industrial instead of clinical or pharmacy practice based triggers, would open up student interest and understanding towards learning pharmaceutics in relation to industrial pharmacy. Two cohorts were monitored through final year examination results and PBL feedback to evaluate student perception and acceptance of the use of PBL. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362177PMC
February 2019

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques.

Saudi Pharm J 2019 Feb 14;27(2):264-273. Epub 2018 Nov 14.

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Apigenin (APG) is a poorly soluble bioactive compound/nutraceutical which shows poor bioavailability upon oral administration. Hence, the objective of this research work was to develop APG solid dispersions (SDs) using different techniques with the expectation to obtain improvement in its in vitro dissolution rate and in vivo bioavailability upon oral administration. Different SDs of APG were prepared by microwave, melted and kneaded technology using pluronic-F127 (PL) as a carrier. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362180PMC
February 2019

Knowledge, attitudes and use of anabolic-androgenic steroids among male gym users: A community based survey in Riyadh, Saudi Arabia.

Saudi Pharm J 2019 Feb 22;27(2):254-263. Epub 2018 Nov 22.

King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of the National Guard Health Affairs, College of Public Health and Health Informatics, Riyadh, Saudi Arabia.

Recreational use of anabolic-androgenic steroids (AAS) is a growing worldwide public health concern. However, studies assessing the level of awareness and knowledge of its effects on health are fairly limited, especially in developing countries, including Saudi Arabia. This community-based cross-sectional study was conducted to assess knowledge, attitudes and practices among male gym members toward AAS in Riyadh (Saudi Arabia) from March to October 2016. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362160PMC
February 2019

Psychotropic drug-prescribing correlates of disorganized speech in Asians with schizophrenia: The REAP-AP study.

Saudi Pharm J 2019 Feb 13;27(2):246-253. Epub 2018 Nov 13.

Department of Psychiatry, Inje University College of Medicine and Haeundae Paik Hospital, Busan, Republic of Korea.

Background: Although disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients.

Objective: We aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study.

Method: A total of 3744 patients with the ICD-10 diagnosis of schizophrenia were enrolled from 71 survey centers in 15 Asian countries/areas. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362172PMC
February 2019

Are dietary supplements containing plant-derived ingredients safe microbiologically?

Saudi Pharm J 2019 Feb 10;27(2):240-245. Epub 2018 Nov 10.

Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Swiecickiego 4, 60-781 Poznan, Poland.

Dietary supplements, particularly those containing ingredients of natural origin, may contain microbiological contaminants, both bacterial and fungal. The present study evaluated the microbiological purity of selected dietary supplements containing plant-based ingredients before their release to the market, as well as raw materials of plant origin which are used in the production of such supplements. A total of 122 samples of supplements and 30 materials of plant origin were studied, with 92. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362155PMC
February 2019

Practices, awareness and attitudes toward self-medication of analgesics among health sciences students in Riyadh, Saudi Arabia.

Saudi Pharm J 2019 Feb 10;27(2):235-239. Epub 2018 Nov 10.

College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, P.O. BOX 3660, Riyadh 11426, Saudi Arabia.

Background: Self-medication is a common practice among health sciences students in Saudi Arabia. It is known that inappropriate selfmedication may harm individuals due to increasing the risk of drug misuse or delaying a hospital visit by masking some symptoms. Thus, the aim of our study is to investigate and assess practices, awareness and attitudes toward analgesics self-medication among health science students in Riyadh, Saudi Arabia. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362167PMC
February 2019

Assessment of the risk of QT-interval prolongation associated with potential drug-drug interactions in patients admitted to Intensive Care Units.

Saudi Pharm J 2019 Feb 10;27(2):229-234. Epub 2018 Nov 10.

Department of Pharmacy, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

Objectives: To evaluate the relationship between drug interactions and QT-interval prolongation in patients admitted to a general intensive care unit (ICU).

Methods: This study was approved by the Institutional Review Board and written informed consent was obtained from all patients. From May 2015 to July 2016, all patients over 18 years-old admitted to the ICU for more than 24 h and in whom the QT-interval on the ECG could be read were prospectively included in this observational, cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362170PMC
February 2019

Attitude and knowledge of Saudi community pharmacists towards use of proton pump inhibitors.

Saudi Pharm J 2019 Feb 7;27(2):225-228. Epub 2018 Nov 7.

Department of Clinical Pharmacy, King Saud University, Saudi Arabia.

Introduction: Proton pump inhibitors (PPIs) effectively suppress acid secretion and play an important role in peptic ulcer disease and gastroesophageal reflux disease There is a real concern about the overutilization of PPIs, which will lead to significant high cost and undesirable outcomes Despite that most of PPIs are classified as prescribed medications, yet most of their users take them without prescription in Saudi Arabia. Therefore, it was important to understand community pharmacists practice in dealing with PPIs and to evaluate their despising pattern of these medications.

Method: A cross-sectional survey-based study that was carried out between September and December 2017. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362272PMC
February 2019