72,835 results match your criteria Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation Saudi Arabia[Journal]


Enhanced remedial effects for vitamin D and calcium co-supplementation against pre-existing lead nephrotoxicity in mice: The roles of renal calcium homeostatic molecules.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 12. Epub 2018 Dec 12.

Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Al Abdeyah, PO Box 7607, Makkah, Saudi Arabia. Electronic address:

Background: Lead (Pb) is a toxic heavy metal and nephropathy is common with chronic exposure. Although vitamin D (VD) and calcium (Ca) showed promising protections, their co-administration was not previously investigated in Pb nephrotoxicity. This study measured the potential interactions and remedial effects of VD and/or Ca on established Pb nephropathy. Read More

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December 2018

Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test.

Behav Brain Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298, USA. Electronic address:

The objective of the present study is to investigate the role of α4, α5, α6 or β2 nAChR subunits in the antidepressant-like effect of bupropion. Adult male mice were treated with subcutaneous acute doses of bupropion (3 and 10 mg/kg) 30 min before the forced swim test (FST) in α4, α5, α6, or β2 nAChR subunit knockout (KO) and wild-type (WT) mice. In addition, the effects of β2* antagonist dihydro-β-erythroidine (DHβE, 3 mg/kg) on antidepressant-like effects of bupropion in C57BL/6 J mice were assessed. Read More

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December 2018

Ki-67 labeling index in glioblastoma; does it really matter?

Hematol Oncol Stem Cell Ther 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Objective/background: Glioblastoma (GB) is the most common primary malignant brain tumor in adults. Ki-67 is a nonhistone nuclear protein that is expressed by cells entering the mitotic cycle and is associated with the transcription of ribosomal RNA (rRNA). In gliomas, the extent of expression of Ki-67 is roughly proportional to the histologic grade. Read More

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December 2018

Essential oils sensory quality and their bioactivity against the mosquito Aedes albopictus.

Sci Rep 2018 Dec 14;8(1):17857. Epub 2018 Dec 14.

Department of Agriculture, Food and Environment - University of Pisa, Pisa, Italy.

Repellents are a main tool to prevent the outbreak of mosquito-borne diseases that represents a threat for millions of people worldwide. Plant-based products are very promising, low-toxic and eco-friendly alternative to synthetic repellents. Here, we performed an olfactory screening of the essential oils (EOs) of Artemisia verlotiorum Lamotte (Asteraceae), Lavandula dentata L. Read More

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December 2018
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Effect of a combined programme of dietary restriction and physical activity on the physical function and body composition of obese middle-aged and older adults with knee OA (DRPA): protocol for a feasibility study.

BMJ Open 2018 Dec 14;8(12):e021051. Epub 2018 Dec 14.

School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.

Introduction: Knee osteoarthritis (OA) is the most common chronic illness among older adults. Up to the submission date of this protocol, there are no published UK studies reporting the efficacy of a combined intervention programme of physical activity and dietary restriction on the musculoskeletal function of obese older adults with knee OA in spite of the clinical recommendation for exercise and diet for people with knee OA. The aim of this study is to assess the feasibility and acceptability of a combined dietary restriction and physical activity intervention programme and collect preliminary data. Read More

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December 2018

The burden and epidemiology of polyparasitism among rural communities in Kano State, Nigeria.

Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.

Department of Parasitology, Faculty of Medicine, University of Malaya,Kuala Lumpur, Malaysia.

Background: Parasitic infections constitute a major public health problem worldwide, particularly among underprivileged communities in developing countries including Nigeria. The present study aimed to determine the epidemiology of polyparasitism (multiple parasitic infections) among rural communities in Kano State, North Central Nigeria.

Methods: A total of 551 individuals were screened for the presence of intestinal, urogenital and blood parasites by using different diagnostic techniques. Read More

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December 2018

Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: Extent and implications for infection control: A systematic review.

Travel Med Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Aix Marseille Univ, Institut de Recherche pour le Développement (IRD), Assistance Publique-Hôpitaux de Marseille (AP-HM), Service de Santé des Armées (SSA), Microbes Vecteurs Infections Tropicales et Méditerranéennes (VITROME), Institut Hospitalo-Universitaire-Méditerranée Infection (IHU-Méditerranée Infection), Marseille, France.

Background: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) emerged in 2012 and attracted an international attention as the virus caused multiple healthcare associated outbreaks. There are reports of the role of asymptomatic individuals play in the transmission of MERS-CoV, however, the exact role is now known.

Method: The MEDLINE/PubMed and Scopus databases were searched for relevant papers published till August 2018 describing asymptomatic MERS-CoV infection. Read More

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December 2018

Effects of Thinking Dispositions, General Ability, Numeracy, and Instructional Set on Judgments and Decision-Making.

Psychol Rep 2018 Dec 14:33294118806473. Epub 2018 Dec 14.

Effat University, Jeddah, Saudi Arabia.

To explore hypotheses based on Stanovich's proposal that analytic processing comprises a reflective-level, an algorithmic level, and specific mindware, 342 participants completed measures of thinking dispositions, general ability (GA), numeracy, and probabilistic and nonprobabilistic reasoning. In a control condition, numeracy predicted probabilistic reasoning at high levels of both thinking dispositions and GA, and GA predicted nonprobabilistic reasoning at high levels of thinking dispositions. In a logic instruction condition, numeracy predicted probabilistic reasoning when GA was high, and GA affected nonprobabilistic reasoning directly. Read More

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December 2018

Comparison of the Photosensitivity of Biofilms of Different Genera of Cariogenic Bacteria in Tooth Slices.

Pol J Microbiol 2018 ;67(4):455-462

Department of Physics, Faculty of Science and Arts, Jordan University of Science and Technology , Irbid , Jordan.

This study compared the outcome of photosensitization on the viability of four different cariogens in planktonic form as well as biofilms in human dentine. Photodynamic therapy was carried out with a gallium aluminium arsenide laser (670 nm wavelength) using Toluidine blue O (TBO) as the photosensitizer. Cariogenic bacteria ( Streptococcus mutans , Lactobacillus casei , Streptococcus salivarius and Actinomyces viscosus ) were exposed to TBO and then to the laser for 1 minute in planktonic suspension. Read More

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January 2018

Is blister grafting an acceptable answer to treating nevus depigmentosus?

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Dermatology, College of Medicine, King Faisal University, Al Ahsa, Saudi Arabia.

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December 2018

Clinical indices and local levels of inflammatory biomarkers in per-implant health of obese and nonobese individuals.

Clin Implant Dent Relat Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan.

Background: Obesity seem to regulate peri-implant health. It is proposed that peri-implant crevicular fluid (PICF) levels of interleukin (IL)-1β and IL-6 are higher in obese as compared to nonobese individuals.

Objective: The purpose of the present clinico-laboratory study is to estimate and compare the clinical and radiographic indices and PICF levels of IL-1β and IL-6 among obese and nonobese patients. Read More

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December 2018

Salt stress under the scalpel - Dissecting the genetics of salt tolerance.

Plant J 2018 Dec 12. Epub 2018 Dec 12.

King Abdullah University of Science and Technology (KAUST), Division of Biological and Environmental Sciences and Engineering, Thuwal, 23955-6900, Kingdom of Saudi Arabia.

Salt stress limits the productivity of crops grown under saline conditions, leading to substantial yield losses in saline soils and under brackish and saline irrigation. Salt tolerant crops could alleviate these losses while both increasing irrigation opportunities and reducing agricultural demands on dwindling freshwater resources. However, despite significant efforts, progress towards this goal has been limited, largely because of genetic complexity of salt tolerance for agronomically important yield-related traits. Read More

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December 2018

Combinatorial Utilization of Murine Embryonic Stem Cells and In Vivo Models to Study Human Congenital Heart Disease.

Curr Protoc Stem Cell Biol 2018 Dec 12:e75. Epub 2018 Dec 12.

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.

We have established an in vitro model of the human congenital heart defect (CHD)-associated mutation NKX2.5 R141C. We describe the use of the hanging drop method to differentiate Nkx2. Read More

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December 2018
1 Read

Association of Group-specific Component Exon 11 Polymorphisms with Bronchial Asthma in Children and Adolescents.

Scand J Immunol 2018 Dec 12:e12740. Epub 2018 Dec 12.

Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Several studies have investigated the association of Group-specific Component (GC) gene, also known as vitamin D binding protein (VDBP), and various respiratory disorder susceptibility with conflicting results. In this sense, we aimed to investigate whether rs7041 and rs4588 variants confer susceptibility to bronchial asthma in a sample of an Egyptian population and to elucidate by in silico analysis the structural and functional impact of these variants. GC polymorphisms rs7041 and rs4588 were genotyped in 192 Egyptian children and adolescents (96 with asthma and 96 healthy controls) by TaqMan single nucleotide polymorphism genotyping assay. Read More

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December 2018

Microbacterium suaedae sp. nov., isolated from Suaeda aralocaspica.

Int J Syst Evol Microbiol 2018 Dec 14. Epub 2018 Dec 14.

6​Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

Two bacterial strains, YZYP 306 and YZGP 509, were isolated from the halophyte Suaeda aralocaspica collected from the southern edge of the Gurbantunggut desert, north-west China. Cells were Gram-stain-positive, aerobic, non-motile, short rods. Strain YZYP 306 grew at 4-40 °C, while strain YZGP 509 grew at 4-42 °C, with optimum growth at 28 °C, and they both grew at pH 6. Read More

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December 2018

Successful percutaneous closure of post myocardial infarction left ventricular ruptured pseudoaneurysm after failed surgical repair.

J Cardiol Cases 2014 Apr 7;9(4):154-157. Epub 2014 Feb 7.

Adult Cardiology Department, Prince Salman Heart Center, King Fahad Medical City, Riyadh, Saudi Arabia.

Left ventricular pseudoaneurysms occur as a consequence of left ventricular free wall rupture contained by pericardium. This clinical situation is an uncommon but lethal complication of acute myocardial infarction. Surgery usually is the preferred therapeutic option but is associated with significant perioperative risk. Read More

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Stenting for huge coronary artery aneurysm and stenosis in a patient with Behçet's disease presenting with non-ST segment elevation myocardial infarction.

J Cardiol Cases 2013 Jul 6;8(1):e3-e6. Epub 2013 Apr 6.

Adult Cardiology Department, Prince Salman Heart Center, King Fahad Medical City, Riyadh 11525, P.O. Box 59046, Saudi Arabia.

Coronary artery aneurysms in patients with Behçet's disease are rare and associated with fatal complications. Covered stents have been used in the management of coronary aneurysms but not in patients with Behçet's disease. We are reporting a rare case of Behçet's disease, admitted with non-ST segment elevation myocardial infarction, whose coronary angiogram revealed huge aneurysm involving proximal left anterior descending artery followed by severe stenosis. Read More

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Progressive coronary aneurysms in Behçet disease, a journey through surgical and percutaneous treatment: A case report.

J Cardiol Cases 2016 Jul 14;14(1):32-34. Epub 2016 Apr 14.

Heart Center, King Faisal Hospital and Research Center, Riyadh, Saudi Arabia.

Behçet disease is a systemic autoimmune disease that causes inflammation within the vascular tree. Coronary arteries are rarely involved with stenosis, arteritis or aneurysm formation. Treatment is mainly directed to reduce the burden of inflammation systemically with steroid and immunosuppressive medications. Read More

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An unusual cardiac mass: Echocardiography, computed tomography, and magnetic resonance imaging.

J Cardiol Cases 2016 May 26;13(5):143-145. Epub 2016 Feb 26.

King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Cardiac tuberculosis is rare. We report an unusual case of cardiac tuberculoma diagnosed in vitam in a 38-year-old woman, with end-stage renal disease and discovered to have mediastinal tuberculosis in 2013. She presented to the emergency department complaining of fever and chills during hemodialysis. Read More

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May 2016
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Levels of heavy metals in a multifloral Saudi honey.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Plant Protection, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh, 11451, Saudi Arabia.

The presence of chemical pollutants, especially heavy metals, affects the quality of honey. The objective of this study was to determine the levels of eight heavy metals (As, Cd, Co, Cr, Cu, Ni, Pb, and Zn) in honey samples from Al-Baha region in Saudi Arabia, using inductively coupled plasma with optical emission spectroscopy (ICP-OES). The highest concentration was found for Zn (1707. Read More

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December 2018
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The Role of Vitamins and Minerals in Hair Loss: A Review.

Dermatol Ther (Heidelb) 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.

People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Read More

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December 2018
2 Reads

Stroke in the Arab World: A bibliometric analysis of research activity (2002-2016).

eNeurologicalSci 2018 Dec 22;13:40-45. Epub 2018 Nov 22.

Department of Neurology, Henri-Mondor Hospital, UPEC, Assistance Publique-Hopitaux de Paris, Creteil, France.

Background: The Arab world has an increasing prevalence of strokes, a leading cause of death in this part of the world.

Aims: The aim of this article is to quantify the stroke research activity in the Arab countries over the past 15 years taking into consideration the population, GDP, and DALY of each country.

Methods: A PubMed search was conducted to find stroke research articles published from the Arab countries between 2002 and 2016 (inclusive). Read More

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December 2018

A data article on E-supply chain benefits from supplier׳s perspective.

Data Brief 2018 Dec 23;21:2441-2446. Epub 2018 Nov 23.

Institute of Public Administration, Riyadh, Saudi Arabia.

This data article provides numeric values about one of the most important sectors in Dubai, Dubai Central Fruit and Vegetable Market (DCM), which attracted world attention through its solid infrastructure and outstanding business environment. The dataset has been collected using a questionnaire obtained from the operational managers in the selected market, and several ethical considerations during the data collection process have been applied to assure the quality and credibility of the obtained data. A structural equation modeling (SEM) was applied using IBM SPSS AMOS. Read More

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December 2018

Data on hypoxia-induced VEGF, leptin and NF-kB p65 expression.

Data Brief 2018 Dec 1;21:2395-2397. Epub 2018 Nov 1.

Department of Cell Biology, Riyadh 11211, Saudi Arabia.

The data set presented here is associated with the article "Intracellular calcium and NF-B regulate hypoxia-induced leptin, VEGF, IL-6 and adiponectin secretion in human adipocytes" (Al-Anazi et al., 2018). Data illustrate hypoxia-induced VEGF and leptin expression in human adipocytes treated with the calcium chelator BAPTA-AM (1 µM). Read More

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December 2018
1 Read

Time-resolved universal temperature measurements using NaYF:Er,Yb upconverting nanoparticles in an electrospray jet.

Beilstein J Nanotechnol 2018 21;9:2916-2924. Epub 2018 Nov 21.

Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701, USA.

Hexagonal upconverting nanoparticles (UCNPs) of NaYF:Er,Yb (ca. 300 nm) have been widely used to measure the temperature at the nanoscale using luminescence ratio thermometry. However, several factors limit their applications. Read More

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November 2018

Ultrathin-Film Titania Photocatalyst on Nanocavity for CO Reduction with Boosted Catalytic Efficiencies.

Global Chall 2018 Nov 19;2(11):1800032. Epub 2018 Sep 19.

Department of Chemical and Biomolecular Engineering University of Maryland College Park MD 20742 USA.

Photocatalytic CO reduction with water to hydrocarbons represents a viable and sustainable process toward greenhouse gas reduction and fuel/chemical production. Development of more efficient catalysts is the key to mitigate the limits in photocatalytic processes. Here, a novel ultrathin-film photocatalytic light absorber (UFPLA) with TiO films to design efficient photocatalytic CO conversion processes is created. Read More

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November 2018

The activity of indenylidene derivatives in olefin metathesis catalysts.

Beilstein J Org Chem 2018 30;14:2956-2963. Epub 2018 Nov 30.

Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, c/ Mª Aurèlia Capmany 69, 17003 Girona, Catalonia, Spain.

The first turnover event of an olefin metathesis reaction using a new family of homogenous Ru-based catalysts bearing modified indenylidene ligands has been investigated, using methoxyethylene as a substrate. The study is carried out by means of density functional theory (DFT). The indenylidene ligands are decorated with -methyl and isopropyl groups at both positions of their phenyl ring. Read More

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November 2018

Synthesis of indole-cycloalkyl[]pyridine hybrids via a four-component six-step tandem process.

Beilstein J Org Chem 2018 22;14:2907-2915. Epub 2018 Nov 22.

Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India.

The one-pot four-component reaction of 3-(1-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation-nucleophilic addition to carbonyl-Michael addition-N-cyclization-elimination-air oxidation sequence to afford structurally intriguing indole-cycloalkyl[]pyridine-3-carbonitrile hybrid heterocycles in excellent yields. Read More

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November 2018

Management of myofascial pain dysfunction syndrome with meditation and yoga: Healing through natural therapy.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):155-159

Department of Public Health Dentistry, ESIC Dental College and Hospital, Rohini, Delhi, India.

Aims And Objectives: Aims and objectives of the study were to study the effectiveness of Raj-yoga meditation and pranayama in patients with myofascial pain dysfunction syndrome (MPDS) and compared the effects with ongoing conventional noninvasive treatment modalities.

Materials And Methods: The study comprised 30 patients divided equally (10 each) into 3 group, i.e. Read More

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December 2018
1 Read

Light intensity output of visible light communication units and clinicians' knowledge and attitude among Riyadh private clinics.

J Conserv Dent 2018 Nov-Dec;21(6):667-670

Department of Restorative, College of Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia.

Background: With the evolution of bonded restorations, visible light-curing units became inseparable from the practice of dentistry. This study was designed to evaluate light intensity output of light-emitting diode (LED) units used in private clinics in Riyadh, Saudi Arabia, and to investigate dentists' knowledge and attitude regarding the usage of light-curing units.

Methodology: Two hundred randomly selected LED units' light intensity output was evaluated using Demetron LED Radiometer-Kerr among evenly distributed private clinics in Riyadh, Saudi Arabia. Read More

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December 2018

Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation.

Bone Marrow Transplant 2018 Dec 13. Epub 2018 Dec 13.

Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

We analyzed CIBMTR data to evaluate the incidence of non-relapse mortality (NRM) and association with overall survival (OS) for bacterial blood stream infections (BSIs) occurring within 100 days of alloHCT in 2 different phases: pre-/peri-engraftment (BSI very early phase, BSI-VEP) and BSI post-engraftment (BSI occurring between 2 weeks after engraftment and day 100, late early phase, BSI-LEP). Of the 7128 alloHCT patients, 2656 (37%) had ≥1 BSI by day 100. BSI-VEP, BSI-LEP, and BSI-Both constituted 56% (n = 1492), 31% (n = 824), and 13% (n = 340) of total BSI, respectively. Read More

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December 2018

Multi-inch single-crystalline perovskite membrane for high-detectivity flexible photosensors.

Nat Commun 2018 Dec 13;9(1):5302. Epub 2018 Dec 13.

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education; Shaanxi Key Laboratory for Advanced Energy Devices; Shaanxi Engineering Lab for Advanced Energy Technology; Institute for Advanced Energy Materials; School of Materials Science and Engineering, Shaanxi Normal University, 710119, Xi'an, P. R. China.

Single crystalline perovskites exhibit high optical absorption, long carrier lifetime, large carrier mobility, low trap-state-density and high defect tolerance. Unfortunately, all single crystalline perovskites attained so far are limited to bulk single crystals and small area wafers. As such, it is impossible to design highly demanded flexible single-crystalline electronics and wearable devices including displays, touch sensing devices, transistors, etc. Read More

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December 2018
2 Reads

Investigations of the Tribological Performance of A390 Alloy Hybrid Aluminum Matrix Composite.

Materials (Basel) 2018 Dec 12;11(12). Epub 2018 Dec 12.

Mechanical Engineering Department, College of Engineering, King Khalid University, Abha 61413 Asir, Saudi Arabia.

Several challenges stand in the way of the production of metal matrix composites (MMCs) such as higher processing temperatures, particulate mixing, particulate⁻matrix interface bonding issues, and the ability to process into desired geometrical shapes. Although there are many studies showing composites with single particulate reinforcements, studies on composites with multiple reinforcing agents (hybrid composites) are found to be limited. Development of a hybrid particulate composite with optimized mechanical and tribological properties is very significant to suit modern engineering applications. Read More

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December 2018

Synthesis, Antibacterial, and Anti HepG2 Cell Line Human Hepatocyte Carcinoma Activity of Some New Potentially Benzimidazole-5-(Aryldiazenyl)Thiazole Derivatives.

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza 12613, Egypt.

The paper describes the synthesis and biological evaluation of some new benzimidazole derivatives as potent clinical drugs that are useful in the treatment of some microbial infections and tumor inhibition. The starting compound 2-(bromomethyl)-1-benzimidazole () was prepared, and hence underwent interesting functionalization reactions to afford several series of benzimidazole-5-(aryldiazenyl)thiazole derivatives: ⁻, ⁻, and ⁻. The antibacterial activities of the synthesized compounds were evaluated by calculation of the inhibition zone diameter (mm) and the determination of minimum inhibitory concentration (µg/mL) against selected pathogenic bacteria (Gram-positive bacteria) and (Gram-negative bacteria). Read More

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December 2018

Hydrogen Sulfide-Mediated Activation of -Acetylserine (Thiol) Lyase and l/d-Cysteine Desulfhydrase Enhance Dehydration Tolerance in Mill.

Int J Mol Sci 2018 Dec 11;19(12). Epub 2018 Dec 11.

Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Hydrogen sulfide (H₂S) has emerged as an important signaling molecule and plays a significant role during different environmental stresses in plants. The present work was carried out to explore the potential role of H₂S in reversal of dehydration stress-inhibited -acetylserine (thiol) lyase (OAS-TL), l-cysteine desulfhydrase (LCD), and d-cysteine desulfhydrase (DCD) response in arugula ( Mill.) plants. Read More

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December 2018

A Randomized Watermarking Technique for Detecting Malicious Data Injection Attacks in Heterogeneous Wireless Sensor Networks for Internet of Things Applications.

Sensors (Basel) 2018 Dec 9;18(12). Epub 2018 Dec 9.

Computer Science Department, King Saud University, Riyadh 12371, Saudi Arabia.

Using Internet of Things (IoT) applications has been a growing trend in the last few years. They have been deployed in several areas of life, including secure and sensitive sectors, such as the military and health. In these sectors, sensory data is the main factor in any decision-making process. Read More

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December 2018

Effect of Graphene Nanosheets Content on Microstructure and Mechanical Properties of Titanium Matrix Composite Produced by Cold Pressing and Sintering.

Nanomaterials (Basel) 2018 Dec 8;8(12). Epub 2018 Dec 8.

Mechanical Engineering Department, Prince Mohammad Bin Fahd University, Al Khobar 31952, Saudi Arabia.

The effect of graphene nanosheet (GNS) reinforcement on the microstructure and mechanical properties of the titanium matrix composite has been discussed. For this purpose, composites with various GNS contents were prepared by cold pressing and sintering at various time periods. Density calculation by Archimedes' principle revealed that Ti/GNSs composites with reasonable high density (more than 99. Read More

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December 2018
1 Read

Royal Jelly Abrogates Cadmium-Induced Oxidative Challenge in Mouse Testes: Involvement of the Nrf2 Pathway.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt.

The current study examined the efficacy of royal jelly (RJ) against cadmium chloride (CdCl₂)-induced testicular dysfunction. A total of 28 Swiss male mice were allocated into four groups (n = 7), and are listed as follows: (1) the control group, who was intraperitoneally injected with physiological saline (0.9% NaCl) for 7 days; (2) the RJ group, who was orally supplemented with RJ (85 mg/kg daily equivalent to 250 mg crude RJ) for 7 days; (3) the CdCl₂ group, who was intraperitoneally injected with 6. Read More

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December 2018
2 Reads

Current Status of the Degradation of Aliphatic and Aromatic Petroleum Hydrocarbons by Thermophilic Microbes and Future Perspectives.

Authors:
Alexis Nzila

Int J Environ Res Public Health 2018 Dec 7;15(12). Epub 2018 Dec 7.

Department of Life Sciences, King Fahd University of Petroleum and Minerals Dhahran, PO Box 468, Dhahran 31261, Saudi Arabia.

Contamination of the environment by petroleum products is a growing concern worldwide, and strategies to remove these contaminants have been evaluated. One of these strategies is biodegradation, which consists of the use of microorganisms. Biodegradation is significantly improved by increasing the temperature of the medium, thus, the use of thermophiles, microbes that thrive in high-temperature environments, will render this process more efficient. Read More

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December 2018

Direct-Thrombin Inhibitor Utilization in Patients With Heparin-Induced Thrombocytopenia and Undergoing Catheter-Directed Thrombolysis: A Summary of Published Case Reports.

J Cardiovasc Nurs 2018 Dec 11. Epub 2018 Dec 11.

Hisham A. Badreldin, PharmD, BCPS, ASH-CHC Assistant Professor of Pharmacy Practice, King Saud bin Abdulaziz University for Health Sciences, and Cardiovascular Clinical Pharmacist, King Abdulaziz Cardiac Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia. Ghada Albassam, PharmD Teaching Assistant of Pharmacy Practice, King Saud bin Abdulaziz University for Health Sciences, and Pharmacist, King Abdulaziz Medical City, Riyadh, Saudi Arabia. Maha Aldoughaim, PharmD Teaching Assistant of Pharmacy Practice, King Saud bin Abdulaziz University for Health Sciences, and Pharmacist, King Abdulaziz Medical City, Riyadh, Saudi Arabia. Majed Alyami, PharmD, BCPS, ASH-CHC Assistant Professor of Pharmacy Practice, King Saud bin Abdulaziz University for Health Sciences, and Clinical Pharmacist, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Background: Catheter-directed thrombolysis (CDT) is one of the emerging venous thromboembolism management modalities. There are fairly limited data regarding the use of direct-thrombin inhibitors (DTIs) in patients with heparin-induced thrombocytopenia and undergoing CDT.

Objectives: The aim of this study was to provide a summary of the available evidence supporting the use of DTIs in patients undergoing CDT. Read More

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December 2018

COMPASS for Vascular Surgeons: Practical Considerations.

Curr Opin Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, University of Toronto.

Purpose Of Review: To suggest a practical approach for the application of data from the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial in patients with peripheral artery disease (PAD).

Recent Findings: The COMPASS trial showed that low-dose rivaroxaban 2.5 mg twice daily plus daily aspirin was superior to aspirin alone in reducing major adverse cardiovascular and cerebrovascular events, and major adverse limb events among patients with stable atherosclerotic vascular disease, including those with PAD. Read More

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December 2018

Customized mesoporous metal organic frameworks engender stable enzymatic nanoreactors.

Chem Commun (Camb) 2018 Dec 13. Epub 2018 Dec 13.

Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.

Here, the porosity of a metal organic framework (MIL-101) is tailored by the choice of the solvent occupying the pores in a template free acid etching process. Employing a slightly basic solvent such as DMF afforded big pores around 30 nm (BP-MIL-101). Catalase (CAT), which is a large protein (6 × 10 nm), was successfully encapsulated by a diffusion-based method with a high capacity of 12. Read More

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December 2018

Development of Virus Resistance Transgenic Cotton Using Cotton Leaf Curl Virus Antisense ßC1 Gene.

Authors:
S S Sohrab

Methods Mol Biol 2019 ;1902:293-305

Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Cotton (Gossypium hirsutum L.) is the most economically important crop in the world and produced 90% of the total natural cellulose fiber which is utilized to make cotton fabrics. The production of cotton is affected by many several diseases, and among them, viral disease, especially leaf curl, is the most destructive disease caused by a begomovirus transmitted by whiteflies vector. Read More

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January 2019

Engineering Chlamydomonas reinhardtii for Expression of Functionally Active Human Interferon-α.

Mol Biotechnol 2018 Dec 12. Epub 2018 Dec 12.

Biology Department, Faculty of Science Yanbu, Taibah University, King Khalid Rd, Al amoedi, Yanbu El-Bahr, 46423, Saudi Arabia.

Human interferon (IFN) are secreted cytokines that play a major regulatory role in response to various infections. Commercially, IFN-α has been approved to treat many chronic viral diseases as well as a variety of cancers and different types of leukemia. In this study, a binary vector containing human IFN-α2a gene under the regulation of the cauliflower mosaic virus 35S promoter was constructed. Read More

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December 2018

Microbiota in cancer development and treatment.

J Cancer Res Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan.

Purpose: Human microbiota comprises of a variety of organisms ranging from bacterial species to viruses, fungi, and protozoa which are present on the epidermal and mucosal barriers of the body. It plays a key role in health and survival of the host by regulation of the systemic functions. Its apparent functions in modulation of the host immune system, inducing carcinogenesis and regulation of the response to the cancer therapy through a variety of mechanisms such as bacterial dysbiosis, production of genotoxins, pathobionts, and disruption of the host metabolism are increasingly becoming evident. Read More

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December 2018

Pressure-induced conduction band convergence in the thermoelectric ternary chalcogenide CuBiS.

Phys Chem Chem Phys 2018 Dec 13. Epub 2018 Dec 13.

King Abdullah University of Science and Technology (KAUST), Physical Science and Engineering Divison (PSE), Thuwal 23955-6900, Saudi Arabia.

The electronic and thermoelectric properties of four ternary chalcogenides with space group Pnma, namely, Cu(Sb,Bi)(S,Se)2, are investigated up to 8 GPa hydrostatic pressure using density functional theory combined with semiclassical Boltzmann theory. The effects of the van der Waals interaction are included in all calculations, since these compounds have layered structures. They all have indirect band gaps that decrease monotonically with increasing hydrostatic pressure except for CuBiS2, for which an indirect-indirect band gap transition occurs around 3 GPa, leading to conduction band convergence with a concomitant 20% increase in the Seebeck coefficient. Read More

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December 2018

An IRT-Multiple Indicators Multiple Causes (MIMIC) Approach as a Method of Examining Item Response Latency.

Front Psychol 2018 13;9:2177. Epub 2018 Nov 13.

Psychology Department, College of Education, King Saud University, Riyadh, Saudi Arabia.

The analysis of response time has received increasing attention during the last decades, since evidence from several studies supported the argument that there is a direct relationship between item response time and test performance. The aim of this study was to investigate whether item response latency affects person's ability parameters, in that it represents an adaptive or maladaptive practice. To examine the above research question data from 8,475 individuals completing the computerized version of the Postgraduate General Aptitude Test (PAGAT) were analyzed. Read More

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November 2018

Atypical cerebral palsy: genomics analysis enables precision medicine.

Genet Med 2018 Dec 13. Epub 2018 Dec 13.

BC Children's Hospital Research Institute, Vancouver, BC, Canada.

Purpose: The presentation and etiology of cerebral palsy (CP) are heterogeneous. Diagnostic evaluation can be a prolonged and expensive process that might remain inconclusive. This study aimed to determine the diagnostic yield and impact on management of next-generation sequencing (NGS) in 50 individuals with atypical CP (ACP). Read More

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December 2018
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Neuroectodermal stem cells: A remyelinating potential in acute compressed spinal cord injury in rat model.

J Biosci 2018 Dec;43(5):897-909

Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia,

The outcomes of compressed spinal cord injury (CSCI) necessitate radical treatment. The therapeutic potential of neuroectodermal stem cells (NESCs) in a rat model of CSCI in acute and subacute stages was assessed. White Wistar rat were divided into control, sham-operated, CSCI untreated model, CSCI grafted with NESCs at 1 day after CSCI, and at 7 days after CSCI. Read More

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December 2018

Simultaneous bilateral posterior ischemic optic neuropathy secondary to giant cell arteritis: a case presentation and review of the literature.

BMC Ophthalmol 2018 Dec 12;18(1):317. Epub 2018 Dec 12.

Neurology division, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: This report highlights a rare case of simultaneous bilateral blindness due to posterior ischemic optic neuropathy. Typically, ophthalmic involvement in giant cell arteritis is monocular or sequential ischemia of the anterior portion of the optic nerve, and less frequently simultaneous.

Case Presentation: An 80-year-old Saudi male came with a history of simultaneous bilateral vision loss 5 days prior to presentation. Read More

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December 2018