72,635 results match your criteria Saudi Medical Journal[Journal]


Case report: Disseminated pulmonary mucormycosis involving spleen in diabetic patient with aggressive surgical approach.

Int J Surg Case Rep 2018 Nov 29;54:42-46. Epub 2018 Nov 29.

Department of General Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Introduction: Mucormycosis is a life threatening fungal infection that occurs in immunocompromised patients.

Presentation Of Case: A 36-year-old Saudi male with known case of Insulin-Dependent Diabetes Mellitus (IDDM), who was presented with productive cough and diarrhea. Computed tomography (CT) revealed a disseminated fungal invasion of the lungs and spleen with invading the fundus of the stomach. Read More

View Article
November 2018

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

View Article
December 2018
5 Reads

Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study.

Clin Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Electronic address:

Objective: Identification of new molecular markers to enhance early diagnosis, prognosis and/or treatment of hepatocellular carcinoma (HCC) is a need. TOM34 (34 kDa-translocase of the outer mitochondrial membrane) protein expression deregulation has demonstrated to be involved in the growth of many cancers. Here, we aimed at evaluating serum TOM34 and some heat shock proteins (HSPA4, HSPA1B, and HSP90AA1) expressions in hepatitis C virus (HCV)-related cirrhosis and HCV-induced HCC relative to controls and correlating these expressions to the clinicopathological data. Read More

View Article
December 2018
6 Reads

The potential role of the sphaeractinomyxon collective group (Cnidaria, Myxozoa) in the life cycle of mugiliform-infecting myxobolids, with the morphological and molecular description of three new types from the oligochaete Tubificoides insularis.

J Invertebr Pathol 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Animal Pathology, Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal; University Institute of Health Sciences & Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central da Gandra no. 1317, 4585-116 Gandra, Portugal.

Three new types of sphaeractinomyxon (Cnidaria, Myxozoa) are described from the coelomic cavity of the marine oligochaete Tubificoides insularis, collected from the Alvor estuary, Algarve, Portugal. Another known type is also registered from this location and host: Sphaeractinomyxon type 10 of Rangel et al., 2016, which was originally described from the marine oligochaete Tubificoides pseudogaster in the Aveiro estuary, Portugal. Read More

View Article
December 2018

Comment on: Factors affecting quality of life in children and adolescents with thalassemia in Iraqi Kurdistan.

Saudi Med J 2018 Dec;39(12):1263-1264

Department of Pediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq. E-mail.

[No Abstract Available]. Read More

View Article
December 2018

Trends in the incidence and mortality of cancer in Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1259-1262

Biochemistry Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. E-mail.

Objectives: To analyze the overall trends in cancer incidence and mortality in Saudi Arabia between 1990 and 2016.   Methods: Data were retrieved through a Global Burden of Disease (GBD, 2016) database (Viz Hub) that is developed by the Institute for Health Metrics and Evaluation at the University of Washington. Results: The incidence of cancer increased around 26-fold for thyroid cancer; approximately 10-fold in breast, colon, bladder and uterine cancers; 8-fold for prostate cancer; 5-fold for renal cancer; 4-fold for pancreatic and ovarian cancer; 3. Read More

View Article
December 2018
3 Reads

New variants in beta globin gene among the Palestinian refugees with sickle cell disease in Lebanon.

Saudi Med J 2018 Dec;39(12):1253-1258

Department of Biological Sciences, Beirut Arab University, Beirut, Lebanon. E-mail.

Objectives: To examine the association between beta-globin sequence variations and phenotypes of sickle-cell disease (SCD) complications among Palestinian refugees in Lebanon correlating them with chromatographic readings and co-inheritance with β-thalassemia traits.   Methods: This cross-sectional study included 47 Palestinian refugees aged 4 to 54 living in different regions in Lebanon during the year 2015. Participant filled a well-designed questionnaire. Read More

View Article
December 2018
2 Reads

Emergent surgical treatment of lethal valve dysfunction during pregnancy in a last-trimester patient.

Saudi Med J 2018 Dec;39(12):1249-1252

Department of Cardiovascular Surgery, Selcuk University, Konya, Turkey. E-mail.

A mechanical heart valve thrombosis during pregnancy is one of the most lethal conditions to experience due to its detrimental effects on both mother and fetus. Cardiac surgery during pregnancy is reserved for cases where medical treatment fails due to harmful maternal and fetal effects. A 24-year-old female in the 38th week of pregnancy was admitted to the emergency room with aggravated dyspnea, tachypnea, and palpitations. Read More

View Article
December 2018

Development of an oral anticoagulant-use attitude scale, and assessment of its validity and reliability.

Saudi Med J 2018 Dec;39(12):1242-1248

Department of Fundamentals, Sakarya University, Sakarya, Turkey. E-mail.

Objectives: To develop a reliable scale that can measure the attitudes of individuals using oral anticoagulant drugs (OACs). Methods: This methodological study was conducted with 296 followed-up individuals using OACs for at least 6 months and visiting the cardiology and neurology clinics of a hospital in Turkey during 2017. A 20-item pool was used to construct the scale and all items were found suitable after content validity analysis and preliminary testing. Read More

View Article
December 2018

Does skin thickness affect satisfaction post rhinoplasty? Middle Eastern population as an example.

Saudi Med J 2018 Dec;39(12):1238-1241

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To determine the mean nasal skin thickness in the Middle Eastern population and to assess the effect of skin thickness on patients' satisfaction following rhinoplasty surgeries. Methods: Radiological measurements of skin thickness at the 3 vertical thirds of the nasal dorsum were taken. A total of 154 patients (80 females and 74 males) who were scheduled for computed tomography scan for the paranasal sinuses were included in the study. Read More

View Article
December 2018
2 Reads

Surgical practice among pediatric surgeons and pediatric urologists in the Kingdom of Saudi Arabia for the management of suspected testicular torsion.

Saudi Med J 2018 Dec;39(12):1232-1237

Division of Pediatric Surgery, Department of Surgery, College of Medicine, Taibah University, Almadinah Al-munawarah, Kingdom of Saudi Arabia. E-mail.

Objectives: To review and compare clinical practice and experience among pediatric surgeons (PS) and pediatric urologists (PU) for the management of testicular torsion (TT) in the Kingdom of Saudi Arabia (KSA).

Methods: This was a cross-sectional study conducted between August 2016 and November 2017, among all PU and PS involved in the management of suspected TT in KSA. A questionnaire was distributed to participants through the Survs. Read More

View Article
December 2018

Knowledge and attitude toward hemoglobinopathies premarital screening program among unmarried population in western Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1226-1231

Department of Hematology, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess the knowledge and attitude toward hemoglobinopathies premarital screening (PMS) program among unmarried population in Jeddah, Kingdom of Saudi Arabia.

Methods: A cross-sectional study was conducted among 1039 unmarried males and females from the general population who fulfilled the eligibility criteria. Data was collected from July-December 2017, using an electronic questionnaire to assess the socio-demographic data, knowledge and attitudes of the participants regarding PMS. Read More

View Article
December 2018

Knowledge and practice in the management of asymptomatic hyperuricemia among primary health care physicians in Jeddah, Western Region of Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1218-1225

Joint Program of Family Medicine, King Fahad Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess knowledge and practice levels in asymptomatic hyperuricemia (AH) and investigate predictors of urate-lowering therapy (ULT) misprescribing among primary health care (PHC) physicians.

Methods: A cross-sectional study was conducted among 201 PHC physicians from December 2017 to May 2018. A based clinical guidelines for hyperuricemia management from American Professional Organizations, a semi-structured questionnaire was administered to collect demographic and professional data; knowledge and practice levels in management of AH; and barriers to the management of hyperuricemia and gout, with focus of the misprescribing of ULT in AH. Read More

View Article
December 2018

Recent-onset of rheumatoid arthritis leads to increase in wall thickness of left anterior descending coronary artery. An evidence of subclinical coronary artery disease.

Saudi Med J 2018 Dec;39(12):1213-1217

Ministry of Health and Prevention, Dubai, United Arab Emirates. E-mail.

Objectives: To explore the atherosclerotic changes of the left anterior descending coronary artery (LADCA) in patients with early onset of rheumatoid arthritis (RA).

Methods: Transthoracic echocardiographic scans were performed on 15 early RA patients and 20 control subjects, free of rheumatological diseases, diabetes mellitus (DM), and cardiovascular disease (CVD). Out of 15 RA patients, 10 were matched for age and gender with control. Read More

View Article
December 2018
0.554 Impact Factor

Risk of potential drug-drug interactions in the cardiac intensive care units. A comparative analysis between 2 tertiary care hospitals.

Saudi Med J 2018 Dec;39(12):1207-1212

Department of Pharmacy, Sarhad University of Science and IT, Peshawar, Pakistan. E-mail.

Objectives: To identify and compare the prevalence of drug-drug interactions (DDIs) in the intensive cardiac care units (CCUs) of 2 tertiary care hospitals and analyze their association with various predictors. Methods: This one-year prospective cross-sectional study was conducted in 2 tertiary care hospitals of Peshawar, Khyber Teaching Hospital (KTH) and Hayatabad Medical Complex (HMC), Peshawar, Pakistan, between January 2014 to Janury 2015. The patient medication profiles from the respective CCUs were evaluated for potential DDIs (PDDIs) using Micromedex DrugReax and Drug interaction facts. Read More

View Article
December 2018

War against respiratory syncytial virus. An 8-year experience at a tertiary hospital.

Authors:
Adel S Al Harbi

Saudi Med J 2018 Dec;39(12):1200-1206

Department of Pediatric Pulmonary Medicine, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess the respiratory syncytial virus (RSV) infection incidence rate through the analysis of data collected before and after implementation of a new palivizumab dosing regimen customized for a high-risk Saudi population. Methods: This was a retrospective cohort study performed at Prince Sultan Military Medical City, Riyadh, Saudi Arabia between November 2009 and April 2017 on 1704 high risk Saudi young children and comparing 3 palivizumab regimens: a 4-week interval dosing regimen starting in either November or mid-September and a 3-week interval dosing regimen starting in mid-September. Results: Despite a decrease in the incidence rate of RSV infection with the three-week interval regimen (3. Read More

View Article
December 2018

Screening for Q fever. A tertiary care hospital-based experience in central Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1195-1199

Department of Pathology, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To evaluate the presence of Coxiella burnetii  (C. brunetii) infection among patients presenting with fever of unknown origin (FUO).

Methods: A cross-sectional study of 100 patients (54 men and 46 women; mean age: 34. Read More

View Article
December 2018

Risk factors and molecular features of extended-spectrum beta-lactamase producing bacteria at southwest of Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1186-1194

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To explore the risk factors, the prevalence rate, and gene types of extended-spectrum beta-lactamase (ESBL)-producing bacteria as the causative agents of infection at King Abdulaziz Specialist Hospital (KAASH), Taif, Kingdom of Saudi Arabia. Methods: This was a retrospective study conducted during the period between February 2017 and January 2018. All samples obtained from the KAASH were analyzed. Read More

View Article
December 2018
2 Reads

Premarital hepatitis screening. Attitude towards screening and the risk factors for transmission.

Saudi Med J 2018 Dec;39(12):1179-1185

College of Medicine, Qassim University, Qassim, Kingdom of Saudi Arabia. E-mail.

Objective: To explore all research articles investigating hepatitis premarital screening programs (PSPs) worldwide, considering all different outcomes of such programs, including efficacy, possible limitations to screening, and participants' knowledge and satisfaction regarding the program. Methods: The present systematic review used the databases of PubMed, Ovid Medline, and Google Scholar to search for articles related to both PSPs and the hepatitis viruses. Research articles were identified between October and December 2017, and articles were selected and extracted based on predefined inclusion and exclusion criteria from the year 1957 up to 2017. Read More

View Article
December 2018
1 Read

The Applications of 3d Printing in Pulmonary Drug Delivery and Treatment of Respiratory Disorders.

Curr Pharm Des 2018 Dec 6. Epub 2018 Dec 6.

Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Pde, Parkville VIC. Australia.

Background: Pulmonary diseases are the third leading cause of morbidity worldwide, however treatment and diagnosis of these diseases continues to be challenging due to the complex anatomical structure as well as physiological processes in the lungs.

Methods: 3D printing is progressively finding new avenues in the medical field and this technology is constantly being used for diseases where diagnosis and treatment heavily rely on the thorough understanding of complex structural-physiology relationships. The structural and functional complexity of the pulmonary system makes it well suited to 3D printing technology. Read More

View Article
December 2018
2 Reads

3D printing Technology in drug delivery: Recent progress and Application.

Curr Pharm Des 2018 Dec 6. Epub 2018 Dec 6.

College of Pharmacy and Dentistry, Buraydah Private Colleges, Buraydah. Saudi Arabia.

Background: 3D printing technology is a new chapter in pharmaceutical manufacturing and has gained vast interest in the recent past as it offers significant advantages over traditional pharmaceutical processes. Advances in technologies can lead to design of suitable 3D printing device capable of producing formulations with intended drug release.

Methods: This review summarizes the applications of 3D printing technology in various drug delivery systems. Read More

View Article
December 2018

3D Printing Methods for Pharmaceutical Manufacturing: Opportunity and Challenges.

Curr Pharm Des 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi-110062. India.

Background: A recently FDA approved 3D printed drug is paving a path for new pharmaceutical manufacturing era. The 3D printing is a novel approach of producing 3D pharmaceuticals from digital designs, in a layer-by-layer fashion. However, traditional manufacturing of drug products are being carried out from decades with well-established manufacturing processes and with well approved regulatory guidelines but these processes are too obsolete in concern of process aptitude and manufacturing flexibility. Read More

View Article
December 2018
1 Read
3.452 Impact Factor

Casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of STAT3 signaling cascade.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Casticin (CTC), one of the major components of Vitex rotundifolia L., has been reported to exert significant beneficial pharmacological activities and can function as an antiprolactin, anticancer, anti-inflammatory, neuroprotective, analgesic, and immunomodulatory agent. This study aimed at investigating whether the proapoptotic effects of CTC may be mediated through the abrogation of signal transducers and activators of transcription-3 (STAT3) signaling pathway in a variety of human tumor cells. Read More

View Article
December 2018

Efficacy of external cold and a vibrating device in reducing discomfort of dental injections in children: A split mouth randomised crossover study.

Eur Arch Paediatr Dent 2018 Dec 5. Epub 2018 Dec 5.

Department of Paediatric Dentistry, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Aim: To study the discomfort and fear associated with maxillary infiltration injections when using a combination of external cold and a commercially available vibrating device.

Methodology: A total of 60 children aged 7 years old participated in this split mouth randomised crossover study. The control intervention comprised of the administration of 1. Read More

View Article
December 2018
1 Read

Effect of the strigolactone analogs methyl phenlactonoates on spore germination and root colonization of arbuscular mycorrhizal fungi.

Heliyon 2018 Nov 22;4(11):e00936. Epub 2018 Nov 22.

King Abdullah University of Science and Technology (KAUST), BESE Division, The BioActives Lab, Thuwal, 23955-6900, Saudi Arabia.

Strigolactones (SLs), a novel class of plant hormones, are key regulator of plant architecture and mediator of biotic interactions in the rhizosphere. Root-released SLs initiate the establishment of arbuscular mycorrhizal (AM) symbiosis by inducing spore germination and hyphal branching in AM fungi (AMF). However, these compounds also trigger the germination of root parasitic weeds, paving the way for deleterious infestation. Read More

View Article
November 2018

Lack of Association between Variant rs7916697 in and Primary Open Angle Glaucoma in a Saudi Cohort.

Genet Res Int 2018 1;2018:2148056. Epub 2018 Nov 1.

Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

A case-control genetic association study was performed to investigate whether variant rs7916697 in (), which has been previously reported to be associated with optic disc parameters and primary open angle glaucoma (POAG) in different ethnic groups, is a risk factor for POAG or any of its clinical phenotypes in a Saudi cohort. Genotyping of rs7916697 (G>A) variant was performed in 186 unrelated POAG cases and 171 unrelated nonglaucomatous controls of Saudi origin using real-time Taq-Man® assay. Genotypic and allelic association with POAG and its related clinical indices were evaluated. Read More

View Article
November 2018

Ice ages and butterflyfishes: Phylogenomics elucidates the ecological and evolutionary history of reef fishes in an endemism hotspot.

Ecol Evol 2018 Nov 23;8(22):10989-11008. Epub 2018 Oct 23.

Red Sea Research Center, Division of Biological and Environmental Science and Engineering King Abdullah University of Science and Technology Thuwal Saudi Arabia.

For tropical marine species, hotspots of endemism occur in peripheral areas furthest from the center of diversity, but the evolutionary processes that lead to their origin remain elusive. We test several hypotheses related to the evolution of peripheral endemics by sequencing ultraconserved element (UCE) loci to produce a genome-scale phylogeny of 47 butterflyfish species (family Chaetodontidae) that includes all shallow water butterflyfish from the coastal waters of the Arabian Peninsula (i.e. Read More

View Article
November 2018

Detection of Exon 12 and 14 Mutations in Janus Kinase 2 Gene Including a Novel Mutant in V617F Negative Polycythemia Vera Patients from Pakistan.

J Cancer 2018 21;9(23):4341-4345. Epub 2018 Oct 21.

Cancer and Medical Genetics, CAMS-A, King Saud Bin Abdulaziz University for Health Sciences & King Abdullah International Medical Research Centre (KAIMRC), King Abdulaziz Medical City, National Guard Health Affairs, Al Ahsa, Saudi Arabia.

The most frequently reported genetic aberration among polycythemia vera (PV) patients is a gain of function mutation V617F in exon 14 of Janus kinase 2 (JAK2) gene. However in many investigations, V617F negative PV patients have been reported to harbor mutations in JAK 2 exon 12. We investigated 24 patients with PV (diagnosed following 2016 WHO guidelines) to detect V617F mutation through allele specific PCR. Read More

View Article
October 2018
2 Reads

Microbiota profile in new-onset pediatric Crohn's disease: data from a non-Western population.

Gut Pathog 2018 29;10:49. Epub 2018 Nov 29.

7Physics Department, Boston University, Boston, USA.

Background: The role of microbiota in Crohn's disease (CD) is increasingly recognized. However, most of the reports are from Western populations. Considering the possible variation from other populations, the aim of this study was to describe the microbiota profile in children with CD in Saudi Arabia, a non-Western developing country population. Read More

View Article
November 2018
1 Read

Medical students' perception of international health electives in the undergraduate medical curriculum at the College of Medicine, King Saud University.

Adv Med Educ Pract 2018 8;9:811-817. Epub 2018 Nov 8.

Department of Medical Education, College of Medicine, King Saud University, Riyadh, Saudi Arabia,

Background: International health electives prepare medical students during their student years of medical education in choosing, matching, and succeeding in the residency of their choice. They serve as a unique educational experience prior to residency training.

Objective: This study was conducted to explore 4th- and 5th-year medical students' perspective about international health electives and to evaluate their educational effects. Read More

View Article
November 2018

Radiology learning or teaching subject areas vs modalities: students' perspective and experience at Albaha University.

Adv Med Educ Pract 2018 8;9:791-799. Epub 2018 Nov 8.

Radiology Department, Faculty of Medicine, Albaha University, Albaha, Saudi Arabia,

Introduction: In radiology learning, most of the integrated schools address the subject area as a theme, and several imaging modalities describe the findings. A few schools handle the imaging modalities as a separate theme wherein many subject areas are discussed.

Purpose: The aim of this study was to identify the differences in student achievement in imaging course using the two learning approaches: integration within modalities under the subject area and integration within the subject area under imaging modalities. Read More

View Article
November 2018

Treatment of chronic oroantral fistula with platelet-rich fibrin clot and collagen membrane: a case report.

Clin Cosmet Investig Dent 2018 8;10:245-249. Epub 2018 Nov 8.

Department of Oral Implantology, CA Implantes, São Paulo, Brazil.

An oroantral fistula is a complication of the maxillary posterior teeth that can occur after a tooth extraction that affects the maxillary sinus. Improper management may lead to a persistent fistula, which may become chronic. In this case report, platelet-rich fibrin (PRF) was used with a collagen membrane to close a chronic fistula in a single patient. Read More

View Article
November 2018
1 Read

Dento-skeletal characteristics of cleft patients with missing teeth.

Clin Cosmet Investig Dent 2018 8;10:237-244. Epub 2018 Nov 8.

Advanced Education Program in Orthodontics and Dentofacial Orthopedics, UMKC School of Dentistry, Kansas City, MO, USA.

Objective: The objective of this study was to compare the cephalometric skeletal and dental characteristics of unilateral complete cleft lip and palate (UCCLP) subjects with and without missing teeth.

Design: A retrospective records review was conducted for patients who are being treated at the cleft lip and palate (CLP) clinics in the College of Dentistry.

Methods: Ninety-six consecutive records of non-syndromic UCCLP subjects were recruited (33 subjects without missing teeth, 50 subjects with only one missing tooth, and 13 subjects with two or more missing teeth). Read More

View Article
November 2018

Genetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study.

Pharmgenomics Pers Med 2018 12;11:205-210. Epub 2018 Nov 12.

Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide, SA, Australia.

Purpose: Methotrexate (MTX) treatment is associated with lower blood pressure (BP) and arterial stiffness in rheumatoid arthritis (RA). We investigated associations between single-nucleotide polymorphism (SNP) of the ATP-binding cassette efflux transporter gene (rs2231142), BP, and arterial stiffness in RA patients treated with MTX.

Patients And Methods: Clinical and 24-hour peripheral and central BP, arterial wave reflection (Augmentation Index, AIx), arterial stiffness (Pulse Wave Velocity, PWV), and intracellular MTX polyglutamate (MTXPGs) concentrations were assessed in 56 RA patients on stable treatment with MTX using a repeated cross-sectional study design with measurements at baseline and after 8 months. Read More

View Article
November 2018
1 Read

Drug-resistance profiling and transmission dynamics of multidrug-resistant in Saudi Arabia revealed by whole genome sequencing.

Infect Drug Resist 2018 12;11:2219-2229. Epub 2018 Nov 12.

Mycobacteriology Research Section, Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia,

Background: In Saudi Arabia, cross-border transmission of multidrug-resistant (MDR) complex (MTBC) strains might be particularly fostered by high immigration rates. Herein, we aimed to elucidate the transmission dynamics of MDR-MTBC strains and reveal a detailed prediction of all resistance-conferring mutations for the first- and second-line drugs.

Methods: We investigated all MDR-MTBC strains collected between 2015 and 2017 from provincial mycobacteria referral laboratories and compared demographic and clinical parameters to a cohort of non-MDR-TB patients using a whole genome sequencing approach. Read More

View Article
November 2018

First reported nosocomial outbreak of harboring and in a neonatal intensive care unit in Cairo, Egypt.

Infect Drug Resist 2018 8;11:2211-2217. Epub 2018 Nov 8.

Department of Microbiology, Faculty of Dentistry and Oral Medicine, Future University, Cairo, Egypt.

Introduction: is a significant hospital-acquired pathogen, and many outbreaks of infection have been reported in neonates. We report a sudden breakout of harboring the and metallo-β-lactamase (MBL) genes that occurred from March to August 2015 in the neonatal intensive care unit of Cairo University Hospital, Cairo, Egypt.

Methods: During the study period, 40 nonduplicate clinical isolates of were collected from blood culture samples. Read More

View Article
November 2018

The impact of fatwas on patients' acceptance of enamel matrix derivatives for periodontal regeneration in Saudi Arabia.

Patient Prefer Adherence 2018 12;12:2405-2411. Epub 2018 Nov 12.

Department of Periodontology, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia,

Background: Since the introduction of enamel matrix derivatives (EMD) (Emdogain), it has not been allowed to be used in Saudi Arabia due to the religious restriction on porcine products. This study was conducted to determine the impact of the fatwas permitting the use of EMD and to assess the general perception of using bone-grafting materials in Jeddah, Saudi Arabia.

Materials And Methods: This cross-sectional survey study included 213 patients seeking dental treatment at the Faculty of Dentistry Clinics of King Abdulaziz University, Jeddah, Saudi Arabia. Read More

View Article
November 2018
1 Read

Layer-edge device of two-dimensional hybrid perovskites.

Nat Commun 2018 Dec 5;9(1):5196. Epub 2018 Dec 5.

Computer, Electrical, and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.

Two dimensional layered organic-inorganic hybrid perovskites (2D perovskites) are potential candidates for next generation photovoltaic device. Especially, the out-of-plane surface perpendicular to the superlattice plane of 2D perovskites (layer-edge surface) has presented several exotic behaviors, such as layer-edge states which are found to be crucial for improving the efficiency of 2D perovskite solar cells. However, fundamental research on transport properties of layer-edge surface is still absent. Read More

View Article
December 2018
4 Reads

Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells.

BMC Complement Altern Med 2018 Dec 5;18(1):321. Epub 2018 Dec 5.

Pharmacology and toxicology department, King Saud University, Riyadh, Saudi Arabia.

Background: Eugenol is a natural phenolic compound and possesses anticancer and antibacterial activities. Breast cancer is a major global health problem, and most of the chemotherapeutic agents are highly toxic with long-term side effects. Therefore, this study aimed to explore the possibility of using eugenol as an anti-metastatic and anti-proliferative agent against MDA-MB-231 and SK-BR-3 breast cancer cells. Read More

View Article
December 2018

Public knowledge of dehydration and fluid intake practices: variation by participants' characteristics.

BMC Public Health 2018 Dec 5;18(1):1346. Epub 2018 Dec 5.

Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard Health Affairs (MNGHA), Riyadh, Kingdom of Saudi Arabia.

Background: Dehydration results from a decrease in total body water content either due to less intake or more fluid loss. Common symptoms of dehydration are dry mouth/tongue, thirst, headache, and lethargy. The aim of this study was to assess knowledge of dehydration definition, symptoms, causes, prevention, water intake recommendations and water intake practices among people living in Riyadh, Saudi Arabia. Read More

View Article
December 2018
1 Read

FLAG/FLAG-IDA regimen for children with relapsed/refractory acute leukemia in the era of targeted novel therapies.

J Oncol Pharm Pract 2018 Dec 5:1078155218817816. Epub 2018 Dec 5.

1 Princess Noorah Oncology Center, King Abdulaziz Medical City, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia.

Background: Outcomes of relapsed/refractory childhood acute leukemia remain poor. We analyzed the safety/efficacy of fludarabine, cytarabine, and granulocyte colony stimulating factor, with/without idarubicin (FLAG ± IDA) as salvage therapy compared with recent published results of novel therapies.

Methods: This retrospective study included children aged 1 to 15 years with relapsed/refractory acute leukemia who received FLAG ± IDA salvage therapy from January 2000 to December 2014. Read More

View Article
December 2018

A Cautionary Research Note on Standard Versus Extended Release Tacrolimus.

Prog Transplant 2018 Dec 5:1526924818817070. Epub 2018 Dec 5.

4 Matrix45, Tucson, AZ, USA.

View Article
December 2018

Anti-inflammatory indomethacin analogs endowed with preferential COX-2 inhibitory activity.

Future Med Chem 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.

Aim: The undeniable indomethacin potency has always suffered serious obstacles such as gastric damage. Continuous attempts to develop potent yet safe indomethacin analogs have never ceased.

Results: Herein are new indole derivatives 4a-h and 5a-c, which were synthesized via Fisher indole reaction, evaluated for both their in vivo anti-inflammatory activities using rat paw edema method and their in vitro cyclooxygenase inhibitory activities. Read More

View Article
December 2018

Experimental Evaluation of Interfacial Surface Cracks in Friction Welded Dissimilar Metals through Image Segmentation Technique (IST).

Materials (Basel) 2018 Dec 4;11(12). Epub 2018 Dec 4.

Department of Mechanical Engineering, College of Engineering, King Khalid University, PO Box 9004, Abha 61413, Asir, Kingdom Saudi Arabia.

Surface cracks on the friction welded interface of dissimilar metals are one of the earliest indications of degradation of the joint, which is a critical aspect for the welding strength. By manual inspection of the friction welded joint, observations of irregularities, porosity voids, crack lengths, cracked surfaces, and depth penetrations of two dissimilar metals can be made. Manual inspection purely depends on a quality expert's experience of quantitative analysis and knowledge. Read More

View Article
December 2018

Synthesis of new thiazolo-pyrrolidine-(spirooxindole) tethered to 3-acylindole as anticancer agents.

Bioorg Chem 2018 Oct 23;82:423-430. Epub 2018 Oct 23.

Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia; Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt. Electronic address:

Anticancer therapeutics with profiles of high potency, low toxicity, and low resistance is of considerable interest. A new series of functionalized spirooxindole linked with 3-acylindole scaffold is reported, starting from chalcones derived from 3-acetyl indole with isatin, and l-4-thiazolidinecarboxylic acid. The reactions proceeded regioselectivity, stereoselectivity, without side products in high yield (71-89%). Read More

View Article
October 2018
1 Read

Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions.

Bioorg Chem 2018 Nov 22;84:260-268. Epub 2018 Nov 22.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

Trimellitimides 6-21 were prepared and investigated in vivo for anti-inflammatory and ulcerogenic effects and in vitro for cytotoxicity. They were subjected to in vitro cyclooxygenase (COX-1/2) and carbonic anhydrase inhibition protocols. Compounds 6-11 and 18 exhibited anti-inflammatory activities and had median effective doses (ED) of 34. Read More

View Article
November 2018

Synthesis of novel gallium-68 labeled rhodamine: A potential PET myocardial perfusion agent.

Appl Radiat Isot 2018 Sep 8;144:29-33. Epub 2018 Sep 8.

Cyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia.

Myocardial perfusion imaging (MPI) is one of the most commonly performed investigations in nuclear medicine studies. Due to the physical properties of the positron emitter gallium-68 (Ga) and its availability from Ge/Ga generator, together with the well-known coordination chemistry, we have synthesized Ga-NOTA- and Ga-NODAGA-rhodamine conjugates using a straightforward and a one-step simple reaction. Radiochemical yields were greater than 95% (decay corrected), with total synthesis time of less than 30 min. Read More

View Article
September 2018

Vasculature reconstruction of decellularized liver scaffolds via gelatin-based re-endothelialization.

J Biomed Mater Res A 2018 Dec 3. Epub 2018 Dec 3.

Organ Transplantation Center, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia.

Decellularized liver scaffolds based liver engineering is a promising approach toward developing functional liver surrogates. However, a major obstacle to long-term transplantation is the hemocompatibility of the bioengineered liver surrogates. One approach to improve the hemocompatibility of engineered liver surrogates is re-endothelialization. Read More

View Article
December 2018
2 Reads

Correlates of nurses' motivation and their demographic characteristics.

Nurs Forum 2018 Dec 3. Epub 2018 Dec 3.

Hematopoietic Stem Cell Transplantation, Comprehensive Cancer Center, King Fahad Medical City (KFMC), Riyadh, Saudi Arabia.

Background: Motivation is a significant concern for workforce management in healthcare organizations as it is linked to many important factors, such as performance, staff retention, and satisfaction.

Aim: To assess motivation level, assess sources of motivation, and identify the difference in motivation level in relation to nurses' characteristics.

Setting: The study was carried out in one major tertiary hospital in Riyadh, Kingdom of Saudi Arabia. Read More

View Article
December 2018