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Neurol Sci 2019 Apr 9. Epub 2019 Apr 9.

Laboratory of the Mosaic of Autoimmunity, Federal State Budget Educational Institution of Higher Education "St. Petersburg State University", University Emb., 7-9, Saint-Petersburg, Russia, 199034.

In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. Read More

Lung 2019 Feb 16. Epub 2019 Feb 16.

ILD Center of Excellence, Department of Pulmonology, St. Antonius Hospital, PO Box 2400, 3430 VB, Nieuwegein, The Netherlands.

Purpose: The clinical manifestations of sarcoidosis vary widely, depending on the intensity of the inflammation and the organ systems affected. Hence, sarcoidosis patients may suffer from a great variety of symptoms. The aim of this study was to compare the self-reported burden of sarcoidosis patients in Denmark, Germany and the Netherlands, especially the prevalence of fatigue and small fiber neuropathy (SFN)-related symptoms, as well as differences in treatment strategies. Read More

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.

Background/objectives: No guidelines exist for the investigation of treatable causes of chronic optic neuropathy, including sarcoidosis, lupus, and syphilis. The purpose of this study was to determine the diagnostic yield of screening blood work (ACE (Angiotensin Converting Enzyme) for sarcoidosis, Antinuclear Antibodies (ANA) for lupus, CMIA (chemiluminescence microparticle enzyme immunoassay) for syphilis) and contrast-enhanced MRI brain and orbits in atypical unilateral chronic optic neuropathy.

Subjects/methods: Retrospective review from February 2012 to June 2018 at a neuro-ophthalmology practice. Read More

Acta Dermatovenerol Croat 2018 Oct;26(3):270-272

Gyula Laszlo Fekete, MD, Bdul. 1 Decembrie 1918, no. 211/27, Tg. Mures, Romania:

Dear Editor, Eczema is an inflammatory dermatitis mediated by cellular immunity, with an etiology in which environmental, immunological, and genetic factors are involved. Skin inflammation through proinflammatory cytokines creates a favorable environment for microbial antigens and optimal conditions for infection (1). In case of underlying immunosuppression, inflammatory features of dermatitis and superimposed infections are more severe. Read More

J Med Case Rep 2018 Oct 23;12(1):307. Epub 2018 Oct 23.

Department of Ophthalmology and Visual science, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.

Background: Neurosarcoidosis is a rare complication, and cranial neuropathy is the most frequent manifestation of this disease. However, few cohesive reports have discussed multiple cranial neuropathies in Japanese patients with sarcoidosis. The present report discusses the case of a patient with sarcoid uveitis and multiple neurological findings. Read More

Pan Afr Med J 2018 28;30:67. Epub 2018 May 28.

Service de Neurologie, Hôpital Militaire Moulay Ismail, Meknès, Maroc.

We report the case of a 37-year old patient with right optic neuropathy. Magnetic resonance imaging (MRI) showed T2 hypersignal in the midline, enhanced after gadolinium injection (figure 1). Cerebrospinal fluid (CSF) analysis revealed lymphocytic meningitis with 64 white blood cells associated with hyperproteinorachy. Read More

Respiration 2018;96(2):159-170. Epub 2018 Jul 6.

Division of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Chronic pulmonary aspergillosis (CPA) complicates conditions including tuberculosis, chronic obstructive pulmonary disease and sarcoidosis, and is associated with high morbidity and mortality. Surgical cure should be considered where feasible; however, many patients are unsuitable for surgery due to extensive disease or poor respiratory function. Azoles are the only oral drug with anti-Aspergillus activity and itraconazole and voriconazole are considered as first-line drugs. Read More

J Neurol 2018 Aug 19;265(8):1906-1915. Epub 2018 Jun 19.

Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and Transplantation, University College London, London, NW3 2PF, UK.

Objective: Neurological complications of systemic sarcoidosis are uncommon and the natural history and optimal treatments under-researched. With the advent of modern biological therapies, it is important to define the clinical characteristics and immunopathology of the disease.

Methods: Patients referred to and treated within the Centre for Neurosarcoidosis over a 15 year period who had biopsy-proven "highly probable" disease of the central nervous system were studied prospectively. Read More

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Ophthalmology, Manchester Royal Eye Hospital and Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

Sarcoidosis is a multisystem disease of unknown aetiology with pulmonary involvement in most patients. Uveitis is common and often characteristic. We report a case of ocular sarcoidosis with grossly atypical contiguous optic neuropathy and choroiditis and describe the diagnostic challenges in this highly unusual presentation. Read More

J Ophthalmic Inflamm Infect 2018 Apr 18;8(1). Epub 2018 Apr 18.

Department of Ophthalmology, University Hospital Ghent, De Pintelaan 185, 9000, Ghent, Belgium.

Background: Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative.

Findings: A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Read More

Sci Rep 2018 Mar 16;8(1):4734. Epub 2018 Mar 16.

Weill Cornell Medicine-Qatar, Doha, Qatar.

Small fiber neuropathy (SFN) is a common feature of many inflammatory diseases, often presenting with pain and disability. SFN is diagnosed using symptoms, thermal threshold testing, and intra-epidermal nerve fiber quantification. Corneal confocal microscopy (CCM) is an ophthalmic imaging technique which non-invasively quantifies corneal nerve fiber (CNF) density, branch density and length, and has comparable diagnostic and superior ability to identify nerve regeneration compared to skin biopsy. Read More

Pract Neurol 2018 Jun 23;18(3):246-249. Epub 2018 Jan 23.

Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK.

Sarcoidosis is an idiopathic multisystem granulomatous disorder of unknown cause. Nervous system involvement (central and/or peripheral) is uncommon, developing in 5%-10%. The presenting symptoms are variable, reflecting the level of involvement, and frequently fluctuate and progress. Read More

Respir Med 2018 05 20;138S:S24-S30. Epub 2017 Nov 20.

ILD Care Foundation Research Team, Ede, The Netherlands; Dept. of Medical Psychology, St. Elisabeth Hospital Tilburg, Tilburg, The Netherlands; Dept. of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.

Background: Fatigue is a major and disabling problem in sarcoidosis. Knowledge concerning correlates of the development of fatigue and possible interrelationships is lacking.

Objective: A conceptual model of fatigue was developed and tested. Read More

Actas Dermosifiliogr 2018 Mar 6;109(2):162-172. Epub 2017 Dec 6.

Unidad de Alergia Cutánea, Servicio de Dermatología, Hospital General Universitario de Alicante - ISABIAL, Alicante, España.

Introduction: Tattooing has become a popular practice in western countries, particularly among younger populations. Tattoos, however, can cause complications, such as infections, allergic or foreign-body reactions, and even systemic inflammatory responses.

Patients And Methods: We conducted a retrospective study of all patients seen for tattoo-related complications at our skin allergy unit between January 2002 and December 2016. Read More

Joint Bone Spine 2018 Oct 16;85(5):553-559. Epub 2017 Nov 16.

Département de médecine interne, hôpital Lariboisière, université Paris Diderot, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France. Electronic address:

Small fiber neuropathy, which affects the sensory Aδ and C fibers, is now a major diagnostic and therapeutic challenge. Nearly 7% of the general population have chronic neuropathic pain responsible for severe quality-of-life impairments. Awareness must therefore be raised among clinicians of the somatosensory and autonomic symptoms that can reveal small fiber neuropathy, appropriate diagnostic investigations, most common causes, and best treatment options for each patient profile. Read More

Rheum Dis Clin North Am 2017 11 23;43(4):593-606. Epub 2017 Aug 23.

Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, 200 First Avenue Southwest, Rochester, MN 55905, USA; Division of Epidemiology, Department of Health Science Research, Mayo Clinic College of Medicine and Science, 200 First Avenue Southwest, Rochester, MN 55905, USA.

Neurosarcoidosis occurs in 3% to 10% of patients with sarcoidosis. Cranial neuropathy and meningeal involvement are the most common manifestations, but any part of the nervous system can be affected. Definite diagnosis requires the presence of noncaseating granuloma in the nervous system, although histopathologic confirmation is often not obtainable. Read More

Rev Med Interne 2018 Sep 14;39(9):728-737. Epub 2017 Oct 14.

Service de médecine interne, université de Lyon, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France.

Sarcoidosis is one of the leading causes of inflammatory eye disease. Any part of the eye and its adnexal tissues can be involved. Uveitis and optic neuropathy are the main manifestations, which the internists face. Read More

Handb Clin Neurol 2017 ;145:453-474

Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany. Electronic address:

This chapter reviews the diseases of the peripheral nerves from a neuropathologic point of view, with a special focus on specific morphologic changes, and includes a summary of the histopathologic methods available for their diagnosis. As the rate of obesity and the prevalence of type 2 diabetes increase, diabetic neuropathy is the most common cause of peripheral neuropathy. Many systemic disorders with metabolic origin, like amyloidosis, hepatic failure, vitamin deficiencies, uremia, lipid metabolism disorders, and others, can also cause axonal or myelin alterations in the peripheral nervous system. Read More

J Pain Res 2017 26;10:2057-2065. Epub 2017 Aug 26.

Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands.

Small fiber pathology with concomitant chronic neuropathic pain is a common complication of sarcoidosis. The gold standard of diagnosis of small fiber neuropathy (SFN) is the quantification of small nerve fibers in skin biopsies in combination with patient history and psychophysical tests; a new technique is the quantification of small nerve fibers in the cornea using cornea confocal microscopy (CCM). Here, we studied small fiber morphology in sarcoidosis patients with neuropathic pain using skin biopsies, CCM, and quantitative sensory testing (QST). Read More

Curr Opin Ophthalmol 2017 Nov;28(6):587-594

aDepartment of Ophthalmology bDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.

Purpose Of Review: Sarcoidosis is a multisystemic inflammatory disease that commonly affects the eye and less often the neuro-ophthalmic pathways. The manifestations can be quite variable but can have characteristic signs and clinical features. This review provides a comprehensive overview of the various ocular and neuro-ophthalmic manifestations of sarcoidosis, emerging diagnostic measures and approach to treatment. Read More

J Neurol Sci 2017 Aug 27;379:84-88. Epub 2017 May 27.

Neurology Department, Centro Hospitalar do Porto, Porto, Portugal; Unit for Multidisciplinary Research in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Portugal.

Introduction: Neurosarcoidosis occurs in about 5% to 15% of patients with sarcoidosis. The purpose of this study was to identify and characterize a cohort of neurosarcoidosis patients and to review the largest previously reported neurosarcoidosis case series.

Methods: This retrospective study enrolled all patients with the diagnosis of probable or definitive neurosarcoidosis according to Zajicek and Scolding criteria, followed at the neurology department of a tertiary center in Portugal from January 1989 to December 2015. Read More

Neuroepidemiology 2017 10;48(3-4):87-94. Epub 2017 Jun 10.

Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background/aims: Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting.

Methods: Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sarcoidosis from Olmsted County, Minnesota, United States from 1976 to 2013 using individual medical record review. Read More

Invest Ophthalmol Vis Sci 2017 05;58(6):BIO52-BIO60

Araim Pharmaceuticals, Tarrytown, New York, United States.

Purpose: Sarcoidosis frequently is complicated by small nerve fiber loss (SNFL), which can be quantified using corneal confocal microscopy (CCM). Prior studies suggest that the innate repair receptor agonist cibinetide reverses corneal nerve loss. This phase 2b, 28-day, randomized trial of 64 subjects with sarcoid-associated SNFL and neuropathic pain assessed the effect of cibinetide on corneal nerve fiber area (CNFA) and regenerating intraepidermal fibers (GAP-43+) as surrogate endpoints for disease modification, pain severity, and functional capacity (6-minute walk test [6MWT]). Read More

Rev Med Interne 2018 Feb 11;39(2):99-106. Epub 2017 Apr 11.

U1096, service de médecine interne, Normandie univ, UNIROUEN, 76000 Rouen, France.

Small fiber neuropathy (SFN) is still unknown. Characterised by neuropathic pain, it typically begins by burning feet, but could take many other expression. SFN affects the thinly myelinated Aδ and unmyelinated C-fibers, by an inherited or acquired mechanism, which could lead to paresthesia, thermoalgic disorder or autonomic dysfunction. Read More

Respir Med 2017 05 9;126:135-138. Epub 2017 Mar 9.

Cleveland Clinic Foundation, Respiratory Institute, Cleveland, OH, USA.

Objective: Small fiber neuropathy commonly affects patients with sarcoidosis and is often refractory to standard immunosuppressive therapies used for systemic disease. The clinical features of sarcoidosis-associated small fiber neuropathy (SSFN) and its response to medical therapy have not been described in a large population.

Methods: We performed a retrospective review of patients with SSFN seen at the Cleveland Clinic over a 4-year period. Read More

BMC Neurol 2016 Nov 15;16(1):220. Epub 2016 Nov 15.

Department of Neurology, Academic Medical Centre, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam, 1105AZ, The Netherlands.

Background: Neurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome of patients with neurosarcoidosis over the last 35 years.

Methods: We performed a systematic review and meta-analysis of studies on neurosarcoidosis published between 1980 and 2016. Read More

Sarcoidosis Vasc Diffuse Lung Dis 2016 Oct 7;33(3):209-215. Epub 2016 Oct 7.

Detroit Medical Center/Wayne State University.

Background: Neurosarcoidosis is a serious extra pulmonary manifestation of sarcoidosis. Its presentation ranges from peripheral or cranial neuropathy to central nervous system dysfunction. It can mimic stroke or multiple sclerosis. Read More

J Neurol 2016 Dec 11;263(12):2515-2527. Epub 2016 Oct 11.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 275 Charles St./Warren Bldg. 310, Boston, MA, 02114, USA.

Small-fiber polyneuropathy (SFPN) causes non-specific symptoms including chronic pain, cardiovascular, gastrointestinal, and sweating complaints. Diagnosis is made from history and exam in patients with known risk factors such as diabetes, but objective test confirmation is recommended for patients without known risks. If tests confirm SFPN, and it is "initially idiopathic" (iiSFPN), screening for occult causes is indicated. Read More

Neurol Neuroimmunol Neuroinflamm 2016 Oct 2;3(5):e270. Epub 2016 Aug 2.

Departments of Neuro-ophthalmology (D.P.K., B.J.B., E.M.G., G.T.P.), the National Hospital for Neurology and Neurosurgery, The Royal Free Hospital, St Thomas' Hospital, London; James Paget University Hospital (B.J.B.), Great Yarmouth; and University of East Anglia (B.J.B.), Norwich, UK.

Objective: To identify and follow a series of 52 patients with optic neuropathy related to sarcoidosis.

Methods: Prospective observational cohort study.

Results: The disorder was more common in women and affected a wide age range. Read More

Pediatr Neurol 2016 10 27;63:45-52. Epub 2016 Jun 27.

Department of Pediatrics, Louisiana State University, Baton Rouge, Louisiana. Electronic address:

Background: Neurosarcoidosis occurs in fewer than 5% of adults with systemic sarcoid. However, only 53 examples of neurosarcoidosis have been reported in the pediatric population, with nine of those cases being isolated neurosarcoidosis. We present the tenth case of a child with an initial presentation of isolated neurosarcoidosis and a review of the literature. Read More

Pain Rep 2016 Jul 9;1(1):e566. Epub 2016 Aug 9.

Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands.

The innate repair receptor (IRR) is a heteromer of the erythropoietin receptor and the β-common (CD131) receptor, which simultaneously activates anti-inflammatory and tissue repair pathways. Experimental data suggest that after peripheral nerve injury, the IRR is upregulated in the spinal cord and modulates the neurogenic inflammatory response. The recently introduced selective IRR agonist ARA290 is an 11-amino acid peptide initially tested in animal models of neuropathy. Read More

Handb Clin Neurol 2016 ;133:353-76

Moorfields Eye Hospital, The National Hospital for Neurology and Neurosurgery and St. Thomas' Hospital, London, UK. Electronic address:

There are a number of autoimmune disorders which can affect visual function. There are a very large number of mechanisms in the visual pathway which could potentially be the targets of autoimmune attack. In practice it is the retina and the anterior visual pathway (optic nerve and chiasm) that are recognised as being affected in autoimmune disorders. Read More

Medicine (Baltimore) 2016 Apr;95(14):e3277

From the Academic Medical Center, Center of Infection and Immunity Amsterdam (CINIMA), Department of Neurology (SEL, DF, FE, AJV, DV, MCB), Amsterdam, the Netherlands.

The aim of this study was to evaluate clinical characteristics, diagnostic strategy, and treatment in patients with neurosarcoidosis in a tertiary referral centre.In a cross-sectional study, we included all patients with neurosarcoidosis treated at our tertiary referral center between September 2014 and April 2015.We identified 52 patients, among them 1 patient was categorized as having definite neurosarcoidosis, 37 probable neurosarcoidosis, and 14 possible neurosarcoidosis. Read More

Semin Ophthalmol 2016 ;31(1-2):117-30

a Neuro-Ophthalmology Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, and the Harvard Medical School , Boston , Massachusetts , USA.

Any presentation of an optic neuropathy with features that suggest inflammation should be addressed promptly because of blindness and the potential for effective treatment in some cases. A step-wise approach, including laboratory testing and imaging, is often informative, although the diagnosis may remain elusive despite detailed investigation. Read More

Pract Neurol 2016 Apr 13;16(2):96-110. Epub 2016 Jan 13.

Department of Neurology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia Australian National University Medical School, Canberra, Australia.

Optic neuritis is a common problem and most neurologists are familiar with it. Recent studies have suggested that it can be overdiagnosed in as many as 10% of cases. The major reasons for this relate to confusion regarding terminology and lack of familiarity with common mimics. Read More

Clin Chest Med 2015 Dec 26;36(4):727-37. Epub 2015 Sep 26.

ILD Care Foundation Research Team, PO Box 18, Bennekom 6720 AA, The Netherlands; Department of Medical Psychology, St. Elisabeth Hospital Tilburg, Tilburg, The Netherlands; Department of Medical and Clinical Psychology, Tilburg University, PO Box 90153, Tilburg 5000 LE, The Netherlands.

Sarcoidosis is a multisystem disorder of unknown cause(s). Less specific disabling symptoms, including fatigue and physical impairments, may have a major influence on the daily activities and the social and professional lives of the patients, resulting in a reduced quality of life. A multidisciplinary approach focusing on somatic and psychosocial aspects is recommended. Read More

Clin Chest Med 2015 Dec;36(4):669-83

Legacy Devers Eye Institute, 1040 Northwest 22nd Avenue Suite 168, Portland, OR 97210, USA.

Sarcoidosis is one of the leading causes of inflammatory eye disease. Ocular sarcoidosis can involve any part of the eye and its adnexal tissues and may cause uveitis, episcleritis/scleritis, eyelid abnormalities, conjunctival granuloma, optic neuropathy, lacrimal gland enlargement, and orbital inflammation. Glaucoma and cataract can be complications from inflammation itself or adverse effects from therapy. Read More

Clin Chest Med 2015 Dec 26;36(4):643-56. Epub 2015 Sep 26.

Department of Neurology, University of Maryland School of Medicine, 16 S Eutaw Street #500, Baltimore, MD 21201, USA.

Neurosarcoidosis is known as the great mimicker and may appear similar to lymphoma, multiple sclerosis, and other diseases affecting the nervous system. Although definitive diagnosis requires histologic confirmation of the affected neural tissue, characteristic clinical manifestations, gadolinium-enhanced MRI patterns and specific cerebrospinal fluid findings can help support the diagnosis in the absence of neural biopsy. An understanding of the common clinical presentations and diagnostic findings is central to the evaluation and management of neurosarcoidosis. Read More

J Fr Ophtalmol 2016 Feb 12;39(2):e29-32. Epub 2015 Nov 12.

Service d'ophtalmologie, centre hospitalier de Pau, 4, boulevard Hauterive, 64000 Pau, France.

Curr Neurol Neurosci Rep 2015 Dec;15(12):76

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Classic demyelinative optic neuritis is associated with multiple sclerosis and typically carries a good prognosis for visual recovery. This disorder is well characterized with respect to its presentation and clinical features by baseline data obtained through the optic neuritis treatment trial and numerous other studies. Atypical optic neuritis entails clinical manifestations that deviate from this classic pattern of features. Read More

Muscle Nerve 2015 Dec 12;52(6):927-32. Epub 2015 Sep 12.

Brain & Mind Centre, University of Sydney, Sydney, Australia.

Bifacial weakness with paresthesias (BFP) is a subtype of Guillain-Barré syndrome defined by rapidly progressive bilateral facial weakness in the absence of other cranial neuropathies, ataxia, or limb weakness. Many patients also complain of distal limb paresthesias and display diminished or absent deep tendon reflexes. BFP is a localized form of Guillain-Barré syndrome and is thought to be caused exclusively by demyelinating- rather than axonal-type neuropathy. Read More

Pituitary 2016 Feb;19(1):19-29

Division of Endocrinology, Department of Medicine, Emory University, 1365 B Clifton Rd., NE, B6209, Atlanta, GA, 30322, USA.

Purpose: Hypothalamic-pituitary (HP) neurosarcoidosis (NS) accounts for 0.5 % cases of sarcoidosis and 1 % of HP masses. Correlative data on endocrine and neurological outcomes is lacking. Read More

Curr Opin Anaesthesiol 2015 Oct;28(5):537-45

aDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg bDepartment of Pain Medicine cDepartment of Neurology, BG University Hospital Bergmannsheil GmbH, Ruhr University Bochum, Bochum, Germany.

Purpose Of Review: The purpose of this review was to provide an update on the diagnostic tools for neuropathic pain for clinical practice.

Recent Findings: The new definition of neuropathic pain by the International Association for the Study of Pain requires confirmation of a lesion or disease affecting the somatosensory system. In addition to traditional diagnostic procedures, for example, nerve conduction studies, skin biopsies depict morphological alteration and/or rarefication of the small intraepidermal nerve fibers and were recently used to identify small fiber abnormalities, for example, in patients with fibromyalgia or sarcoidosis. Read More

J Clin Neurol 2015 Jul;11(3):234-40

Physical Medicine and Rehabilitation Department, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Background And Purpose: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy. Although its etiology is unknown, certain conditions are commonly associated with CTS, such as obesity, arthritis, hypothyroidism, diabetes mellitus, trauma, mass lesions, amyloidosis, and sarcoidosis. We aimed to determine the association between metabolic syndrome and CTS, and we compared the severity of CTS between patients with diabetes (and no concomitant metabolic syndrome) and patients with metabolic syndrome. Read More

Intern Med 2015 15;54(10):1281-6. Epub 2015 May 15.

Department of Respiratory Medicine, Tsuchiura Kyodo General Hospital, Japan.

A 59-year-old woman was admitted to our hospital for an evaluation of a 10-day history of progressive pain and hypoesthesia of the right lower back associated with fever and constipation. Sarcoidosis was confirmed on mediastinal lymph node and skin biopsies. Although the neurological symptoms were suspected due to sarcoidosis-induced nerve dysfunction, nerve conduction studies and other routine examinations did not show any abnormalities. Read More

Expert Rev Neurother 2015 May;15(5):533-48

Department of Neurology, University of Maryland, 110 S Paca St, Baltimore, MD 21201, USA.

Sarcoidosis is a multi-organ immune-mediated disease, which manifests as neurosarcoidosis (NS) in approximately 10% of all affected patients. The diagnosis of NS requires a high degree of suspicion as well as histological confirmation. Neurological symptoms in patients with systemic sarcoidosis should not be assumed to be due to NS unless proven true. Read More

J Gastrointest Oncol 2015 Apr;6(2):E16-20

1 Department of Neurology, University of Miami, Miami, FL 33136, USA ; 2 Department of Pathology, University of Miami/Jackson Memorial Hospital, Miami, FL, USA.

Numb chin syndrome (NCS) can be a sign of malignancy. Its association with gastric adenocarcinoma is rare. We report a case of a 27-year-old Hispanic female that presented with complaint of left sided headache associated with numbness of the left side of chin and lower gingiva. Read More

Muscle Nerve 2015 Oct 2;52(4):664-8. Epub 2015 Jul 2.

Department of Neurology, University of California San Francisco, 505 Parnassus Avenue, Box 0114, San Francisco, California, 94143, USA.

Introduction: Sarcoid polyneuropathy is a rare and clinically heterogeneous disorder that may be the initial presentation of sarcoidosis.

Methods: We report the clinical, electrophysiological, and pathological findings of a patient who carried a diagnosis of sensory-predominant chronic inflammatory demyelinating polyneuropathy (CIDP) for over a decade but was ultimately found to have sarcoid polyneuropathy.

Results: A 36-year-old man presented with a several-week history of gait difficulty and muscle cramps. Read More

J Cutan Pathol 2015 Jul 12;42(7):465-70. Epub 2015 May 12.

Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

Perineural granulomas in cutaneous sarcoidosis have been rarely reported and their clinical significance has yet to be evaluated. Recently, a 27-year-old male presented with multiple pink papules on the flank and lower back, accompanied by a painful, burning sensation. Biopsies revealed well-defined granulomas, consistent with sarcoidosis, in the dermis and involving small cutaneous nerves. Read More

Ned Tijdschr Geneeskd 2015 ;159:A8383

Leids Universitair Medisch Centrum, afd. Neurologie, Leiden.

The clinical spectrum of neurosarcoidosis is highly diverse; virtually any neurological syndrome can present, depending upon granuloma localization. There are indications that neurosarcoidosis is insufficiently recognized as a separate clinical entity. In the absence of major prospective clinical trials, we launched a large national online registry of neurosarcoidosis patients in the Netherlands in June 2014 at www. Read More