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Semin Respir Crit Care Med 2020 Jun 24. Epub 2020 Jun 24.

Division of Pulmonary, Critical Care and Sleep Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina.

Health-related quality of life (HRQoL) describes an individual's perception of the impact of health, disease, and treatment on their quality of life (QoL). It is a reflection of how the manifestation of an illness and its treatment is personally experienced. Assessing HRQoL is particularly important in sarcoidosis because the attributable disease mortality is relatively low, and one of the major reasons for initiating treatment is to improve quality of life. Read More

Med Clin (Barc) 2020 Jun 18. Epub 2020 Jun 18.

Servicio de Neurología, Hospital Virgen de la Victoria, Málaga, España. Electronic address:

Introduction: Neurosarcoidosis is a rare complication of sarcoidosis. There are small series on the condition and very few from Spain. We conducted a retrospective study of neurosarcoidosis in Virgen de la Victoria Hospital over the last 10 years. Read More

Continuum (Minneap Minn) 2020 06;26(3):695-715

Purpose Of Review: This article provides an overview and update on the neurologic manifestations of sarcoidosis.

Recent Findings: The 2018 Neurosarcoidosis Consortium diagnostic criteria emphasize that biopsy is key for diagnosis and determines the level of diagnostic certainty. Thus, definite neurosarcoidosis requires nervous system biopsy and probable neurosarcoidosis requires biopsy from extraneural tissue. Read More

Neurohospitalist 2020 Apr 24;10(2):118-120. Epub 2019 Jul 24.

Department of Neurology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.

Clinical diagnosis often focuses on identifying the single cause of a patient's symptoms but it is becoming increasingly recognized that a subset of patients exist where 2 pathological entities coexist. These patients present a particular diagnostic challenge because the first "positive" diagnostic test is not the definitive stopping point in their evaluation. Here, we present the case of a 47-year-old woman with multiple cranial neuropathies and a polyradiculopathy. Read More

Clin Neurol Neurosurg 2020 Jul 20;194:105811. Epub 2020 Mar 20.

Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and Transplantation, University College London, London, NW3 2PF, United Kingdom. Electronic address:

Objectives: Neurological complications of sarcoidosis are uncommon and the natural history and optimal treatments under-researched. With the advent of biological therapies, it is important to define the clinical characteristics and immunopathology of the disease.

Patients And Methods: Patients referred to and treated within the Centre for Neurosarcoidosis over a 15 year period who had biopsy proven "highly probable" disease of the central nervous system were studied prospectively. Read More

Retin Cases Brief Rep 2020 Feb 13. Epub 2020 Feb 13.

Ophthalmology Department, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.

Background/purpose: To report a case of unilateral choroidal detachment and serous retinal detachment in a patient with a history of untreated sarcoidosis.

Methods: Case report. The patient is a 67-year-old African American man with a history of nontreated sarcoidosis and prostate cancer. Read More

J Cutan Pathol 2020 Jul 13;47(7):625-627. Epub 2020 Feb 13.

Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Sarcoidosis is a granulomatous condition with diverse clinical presentations, including neurological findings. It was previously hypothesized that perineural sarcoidal granulomas in the skin may be an explanation of small-fiber neuropathy. Herein, we present a case of a 55 year old female with anesthetic cutaneous lesions mimicking leprosy clinically and histopathologically and discuss the importance of this differential diagnosis. Read More

J Ophthalmic Inflamm Infect 2020 Jan 31;10(1). Epub 2020 Jan 31.

Department of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.

Background: The ophthalmic manifestation of neurosarcoidosis is varied. The complication of optic neuropathy and central retinal vein occlusion (CRVO) is rare in sarcoidosis.

Case Report: The patient was a 55-year-old female with systemic sarcoidosis suffering from visual loss as hand motion in her left eye. Read More

BMJ Case Rep 2019 Nov 19;12(11). Epub 2019 Nov 19.

Neurology, North Middlesex University Hospital NHS Trust, London, UK.

Neurosarcoidosis when encountered by neurologists most commonly presents as cranial neuropathy, peripheral mononeuropathy,polyneuropathy, myopathy, meningitis or myelopathy. There are limited reports in the current literature on the cases of neurosarcoidosis patients presenting with ischaemic stroke. We discuss a 52-year-old patient with a known previous history of cutaneous sarcoidosis presenting with an acute third nerve palsy, facial weakness and ataxia. Read More

Monaldi Arch Chest Dis 2019 Sep 10;89(3). Epub 2019 Sep 10.

Intenal Medicine Department, Cerrahpasa Medical Faculty, Istanbul University.

Sarcoidosis is a multisystemic disease that may lead to neurologic complications in 10% of the patients. Carpal tunnel syndrome is very rare in sarcoidosis. We present two identical twin sarcoidosis patients with carpal tunnel syndrome. Read More

J Neuroophthalmol 2020 Jun;40(2):255-257

Division of Neurology, Department of Medicine, Department of Ophthalmology and Vision Sciences (JAM), University of Toronto, Toronto, Canada; Kensington Vision and Research Centre (JAM), Toronto, Canada; Department of Ophthalmology (JAM), St. Michael's Hospital, Toronto, Canada; Department of Laboratory Medicine (CJS), St. Michael's Hospital, Toronto, Canada; and Division of Respirology (KM), Department of Medicine, University of Toronto, St. Michael's Hospital, Toronto, Canada.

A 35-year-old healthy African-American woman presented with a 4-month history of gradual loss of vision in the right eye from an optic neuropathy. MRI of the orbits with gadolinium showed isolated thickening and enhancement of the right optic nerve sheath. Chest x-ray and CT-scan of the chest were performed and showed bilateral hilar and mediastinal lymphadenopathy. Read More

Ther Adv Neurol Disord 2019 12;12:1756286419866367. Epub 2019 Aug 12.

Department of Neurology, Royal Children's Hospital, Murdoch Children's Research Institute and University of Melbourne, Melbourne, Victoria, Australia.

This review is an overview of systemic conditions that can be associated with peripheral nervous system dysfunction. Children may present with neuropathic symptoms for which, unless considered, a causative systemic condition may not be recognized. Similarly, some systemic conditions may be complicated by comorbid peripheral neuropathies, surveillance for which is indicated. Read More

Respiration 2019;98(5):373-382. Epub 2019 Aug 22.

Mild care foundation research team, Ede, The Netherlands.

Background: Consequences of sarcoidosis are wide ranging, and the symptom burden has a great impact on patients' quality of life (QoL). However, the QoL of couples living with sarcoidosis has not yet been studied.

Objectives: Our aim was to assess the QoL of couples living with sarcoidosis and to evaluate whether living with a partner with sarcoidosis influences the partner's QoL. Read More

Curr Opin Pulm Med 2019 09;25(5):533-538

Sarcoidosis Center, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Purpose Of Review: The current review discusses the diagnosis and management of nonorgan-related symptoms that commonly arise in the setting of systemic sarcoidosis. Fatigue, small fiber neuropathy (SFN) and neuropsychological symptoms are highlighted.

Recent Findings: The debilitating effects of chronic nonorgan-based symptoms in sarcoidosis have led to recent studies focusing on incidence rates, contributing factors and potential therapeutic strategies. Read More

J Community Hosp Intern Med Perspect 2019 19;9(3):226-229. Epub 2019 Jun 19.

Department of Medicine, Reading Hospital, Reading, PA, USA.

AL amyloidosis is due to deposition of protein derived from immunoglobulin light chain fragments. It is a systemic disorder in which deposition of plasma proteins can adversely affect function of the heart, liver, kidneys, and peripheral nerves. Deposition in the heart results in a decrease in the amplitude of the electrical activity of the heart and can be an early clue to the diagnosis. Read More

Rev Neurol 2019 Jun;68(12):524-530

Fundacion Favaloro, Buenos Aires, Argentina.

Introduction: Chronic relapsing inflammatory optic neuropathy (CRION) is an inflammatory disease characterized by painful recurrent episodes of optic neuritis with clear response to steroids and relapses with treatment withdrawal.

Aims: To performed a systematic review of the literature about CRION, since 2003 to present in medical database. We excluded pediatric or animal research articles. Read More

Lung 2019 08 17;197(4):407-413. Epub 2019 May 17.

ILD Care Foundation Research Team, Ede, The Netherlands.

Objective: Sarcoidosis, an inflammatory multi-organ disease with a wide variety of clinical manifestations, affecting people of working age. Patients suffer from a broad spectrum of physical symptoms of varying severity that impact function including cognitive impairment and disabling fatigue. The Dutch Sarcoidosis Society identified a knowledge gap in various facets related to work ability. Read More

Rinsho Ketsueki 2019 ;60(4):302-307

Division of Hematology, Hamamatsu University School of Medicine.

A 65-year-old woman was diagnosed with rheumatoid arthritis in 2010 and was treated with methotrexate (MTX). In 2012, she was diagnosed with sarcoidosis and underwent a follow-up therapy for mild peripheral neuropathy due to neurosarcoidosis. In 2018, she experienced primary splenic diffuse large B-cell lymphoma (DLBCL) and was diagnosed with sarcoidosis-lymphoma syndrome (SLS). Read More

Neurol Sci 2019 Jul 9;40(7):1343-1350. Epub 2019 Apr 9.

Laboratory of the Mosaic of Autoimmunity, Federal State Budget Educational Institution of Higher Education "St. Petersburg State University", University Emb., 7-9, Saint-Petersburg, Russia, 199034.

In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. Read More

Lung 2019 04 16;197(2):155-161. Epub 2019 Feb 16.

ILD Center of Excellence, Department of Pulmonology, St. Antonius Hospital, PO Box 2400, 3430 VB, Nieuwegein, The Netherlands.

Purpose: The clinical manifestations of sarcoidosis vary widely, depending on the intensity of the inflammation and the organ systems affected. Hence, sarcoidosis patients may suffer from a great variety of symptoms. The aim of this study was to compare the self-reported burden of sarcoidosis patients in Denmark, Germany and the Netherlands, especially the prevalence of fatigue and small fiber neuropathy (SFN)-related symptoms, as well as differences in treatment strategies. Read More

Eye (Lond) 2019 06 13;33(6):974-979. Epub 2019 Feb 13.

Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.

Background/objectives: No guidelines exist for the investigation of treatable causes of chronic optic neuropathy, including sarcoidosis, lupus, and syphilis. The purpose of this study was to determine the diagnostic yield of screening blood work (ACE (Angiotensin Converting Enzyme) for sarcoidosis, Antinuclear Antibodies (ANA) for lupus, CMIA (chemiluminescence microparticle enzyme immunoassay) for syphilis) and contrast-enhanced MRI brain and orbits in atypical unilateral chronic optic neuropathy.

Subjects/methods: Retrospective review from February 2012 to June 2018 at a neuro-ophthalmology practice. Read More

Sarcoidosis Vasc Diffuse Lung Dis 2019 1;36(4):325-328. Epub 2019 May 1.

Department of Neurology, Asahi General Hospital, Asahi, Chiba, Japan.

Sarcoidosis Vasc Diffuse Lung Dis 2019 1;36(4):254-260. Epub 2019 May 1.

Department of Medicine, University of Cincinnati Medical Center, Cincinnati, OH USA.

Background: Bothersome symptoms from sarcoidosis can develop in the absence of identified granulomas. These parasarcoidosis complaints can include small fiber neuropathy, diaphoresis, dysautonomia, and fatigue. Similar issues are also encountered in some cancer patients, especially those with onconeural antibodies. Read More

Sarcoidosis Vasc Diffuse Lung Dis 2019 1;36(1):2-10. Epub 2019 May 1.

ILD Center of Excellence, Department of Pulmonology, St. Antonius Hospital, Nieuwegein, The Netherlands.

Background: Cognitive failure is associated with memory and concentration problems. Previously, a prevalence of one third was found in a general sarcoidosis population. The aim of this study was to assess if neurosarcoidosis patients are at higher risk for developing everyday cognitive failure using the Cognitive Failure Questionnaire (CFQ) and to determine what factors were associated with cognitive failure. Read More

Acta Dermatovenerol Croat 2018 Oct;26(3):270-272

Gyula Laszlo Fekete, MD, Bdul. 1 Decembrie 1918, no. 211/27, Tg. Mures, Romania:

Dear Editor, Eczema is an inflammatory dermatitis mediated by cellular immunity, with an etiology in which environmental, immunological, and genetic factors are involved. Skin inflammation through proinflammatory cytokines creates a favorable environment for microbial antigens and optimal conditions for infection (1). In case of underlying immunosuppression, inflammatory features of dermatitis and superimposed infections are more severe. Read More

J Med Case Rep 2018 Oct 23;12(1):307. Epub 2018 Oct 23.

Department of Ophthalmology and Visual science, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.

Background: Neurosarcoidosis is a rare complication, and cranial neuropathy is the most frequent manifestation of this disease. However, few cohesive reports have discussed multiple cranial neuropathies in Japanese patients with sarcoidosis. The present report discusses the case of a patient with sarcoid uveitis and multiple neurological findings. Read More

Pan Afr Med J 2018 28;30:67. Epub 2018 May 28.

Service de Neurologie, Hôpital Militaire Moulay Ismail, Meknès, Maroc.

We report the case of a 37-year old patient with right optic neuropathy. Magnetic resonance imaging (MRI) showed T2 hypersignal in the midline, enhanced after gadolinium injection (figure 1). Cerebrospinal fluid (CSF) analysis revealed lymphocytic meningitis with 64 white blood cells associated with hyperproteinorachy. Read More

Respiration 2018;96(2):159-170. Epub 2018 Jul 6.

Division of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Chronic pulmonary aspergillosis (CPA) complicates conditions including tuberculosis, chronic obstructive pulmonary disease and sarcoidosis, and is associated with high morbidity and mortality. Surgical cure should be considered where feasible; however, many patients are unsuitable for surgery due to extensive disease or poor respiratory function. Azoles are the only oral drug with anti-Aspergillus activity and itraconazole and voriconazole are considered as first-line drugs. Read More

J Neurol 2018 Aug 19;265(8):1906-1915. Epub 2018 Jun 19.

Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and Transplantation, University College London, London, NW3 2PF, UK.

Objective: Neurological complications of systemic sarcoidosis are uncommon and the natural history and optimal treatments under-researched. With the advent of modern biological therapies, it is important to define the clinical characteristics and immunopathology of the disease.

Methods: Patients referred to and treated within the Centre for Neurosarcoidosis over a 15 year period who had biopsy-proven "highly probable" disease of the central nervous system were studied prospectively. Read More

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Ophthalmology, Manchester Royal Eye Hospital and Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

Sarcoidosis is a multisystem disease of unknown aetiology with pulmonary involvement in most patients. Uveitis is common and often characteristic. We report a case of ocular sarcoidosis with grossly atypical contiguous optic neuropathy and choroiditis and describe the diagnostic challenges in this highly unusual presentation. Read More

J Ophthalmic Inflamm Infect 2018 Apr 18;8(1). Epub 2018 Apr 18.

Department of Ophthalmology, University Hospital Ghent, De Pintelaan 185, 9000, Ghent, Belgium.

Background: Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative.

Findings: A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Read More

Sci Rep 2018 03 16;8(1):4734. Epub 2018 Mar 16.

Weill Cornell Medicine-Qatar, Doha, Qatar.

Small fiber neuropathy (SFN) is a common feature of many inflammatory diseases, often presenting with pain and disability. SFN is diagnosed using symptoms, thermal threshold testing, and intra-epidermal nerve fiber quantification. Corneal confocal microscopy (CCM) is an ophthalmic imaging technique which non-invasively quantifies corneal nerve fiber (CNF) density, branch density and length, and has comparable diagnostic and superior ability to identify nerve regeneration compared to skin biopsy. Read More

Pract Neurol 2018 Jun 23;18(3):246-249. Epub 2018 Jan 23.

Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK.

Sarcoidosis is an idiopathic multisystem granulomatous disorder of unknown cause. Nervous system involvement (central and/or peripheral) is uncommon, developing in 5%-10%. The presenting symptoms are variable, reflecting the level of involvement, and frequently fluctuate and progress. Read More

Sarcoidosis Vasc Diffuse Lung Dis 2018 9;35(4):333-341. Epub 2020 Mar 9.

ild care foundation research team, Ede, The Netherlands.

Previous studies found that 40-60% of the sarcoidosis patients suffer from small fiber neuropathy (SFN), substantially affecting quality of life. SFN is difficult to diagnose, as a gold standard is still lacking. The need for an easily administered screening instrument to identify sarcoidosis-associated SFN symptoms led to the development of the SFN Screening List (SFNSL). Read More

Sarcoidosis Vasc Diffuse Lung Dis 2018 28;35(1):91-94. Epub 2018 Apr 28.

The Ohio State University.

On April 7 and 8, 2017; the Americas Association for Sarcoidosis and Other Granulomatous Diseases (AASOG) held its annual scientific conference titled "Combining Transformative Sarcoidosis Research and Outreach to Improve Health Disparities" at the Penn State Health, Hershey Campus Conference Center. Participants came from geographically diverse areas of the United States. The demographics of meeting speakers and attendees reflected the gender, racial and ethnic diversity of those who are engaged in the treatment of the disease. Read More

Respir Med 2018 05 20;138S:S24-S30. Epub 2017 Nov 20.

ILD Care Foundation Research Team, Ede, The Netherlands; Dept. of Medical Psychology, St. Elisabeth Hospital Tilburg, Tilburg, The Netherlands; Dept. of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.

Background: Fatigue is a major and disabling problem in sarcoidosis. Knowledge concerning correlates of the development of fatigue and possible interrelationships is lacking.

Objective: A conceptual model of fatigue was developed and tested. Read More

Actas Dermosifiliogr 2018 Mar 6;109(2):162-172. Epub 2017 Dec 6.

Unidad de Alergia Cutánea, Servicio de Dermatología, Hospital General Universitario de Alicante - ISABIAL, Alicante, España.

Introduction: Tattooing has become a popular practice in western countries, particularly among younger populations. Tattoos, however, can cause complications, such as infections, allergic or foreign-body reactions, and even systemic inflammatory responses.

Patients And Methods: We conducted a retrospective study of all patients seen for tattoo-related complications at our skin allergy unit between January 2002 and December 2016. Read More

Joint Bone Spine 2018 10 16;85(5):553-559. Epub 2017 Nov 16.

Département de médecine interne, hôpital Lariboisière, université Paris Diderot, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France. Electronic address:

Small fiber neuropathy, which affects the sensory Aδ and C fibers, is now a major diagnostic and therapeutic challenge. Nearly 7% of the general population have chronic neuropathic pain responsible for severe quality-of-life impairments. Awareness must therefore be raised among clinicians of the somatosensory and autonomic symptoms that can reveal small fiber neuropathy, appropriate diagnostic investigations, most common causes, and best treatment options for each patient profile. Read More

Rheum Dis Clin North Am 2017 11 23;43(4):593-606. Epub 2017 Aug 23.

Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, 200 First Avenue Southwest, Rochester, MN 55905, USA; Division of Epidemiology, Department of Health Science Research, Mayo Clinic College of Medicine and Science, 200 First Avenue Southwest, Rochester, MN 55905, USA.

Neurosarcoidosis occurs in 3% to 10% of patients with sarcoidosis. Cranial neuropathy and meningeal involvement are the most common manifestations, but any part of the nervous system can be affected. Definite diagnosis requires the presence of noncaseating granuloma in the nervous system, although histopathologic confirmation is often not obtainable. Read More

Rev Med Interne 2018 Sep 14;39(9):728-737. Epub 2017 Oct 14.

Service de médecine interne, université de Lyon, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France.

Sarcoidosis is one of the leading causes of inflammatory eye disease. Any part of the eye and its adnexal tissues can be involved. Uveitis and optic neuropathy are the main manifestations, which the internists face. Read More

Handb Clin Neurol 2017 ;145:453-474

Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany. Electronic address:

This chapter reviews the diseases of the peripheral nerves from a neuropathologic point of view, with a special focus on specific morphologic changes, and includes a summary of the histopathologic methods available for their diagnosis. As the rate of obesity and the prevalence of type 2 diabetes increase, diabetic neuropathy is the most common cause of peripheral neuropathy. Many systemic disorders with metabolic origin, like amyloidosis, hepatic failure, vitamin deficiencies, uremia, lipid metabolism disorders, and others, can also cause axonal or myelin alterations in the peripheral nervous system. Read More

J Pain Res 2017 26;10:2057-2065. Epub 2017 Aug 26.

Department of Anesthesiology, Leiden University Medical Center, Leiden, the Netherlands.

Small fiber pathology with concomitant chronic neuropathic pain is a common complication of sarcoidosis. The gold standard of diagnosis of small fiber neuropathy (SFN) is the quantification of small nerve fibers in skin biopsies in combination with patient history and psychophysical tests; a new technique is the quantification of small nerve fibers in the cornea using cornea confocal microscopy (CCM). Here, we studied small fiber morphology in sarcoidosis patients with neuropathic pain using skin biopsies, CCM, and quantitative sensory testing (QST). Read More

Curr Opin Ophthalmol 2017 Nov;28(6):587-594

aDepartment of Ophthalmology bDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.

Purpose Of Review: Sarcoidosis is a multisystemic inflammatory disease that commonly affects the eye and less often the neuro-ophthalmic pathways. The manifestations can be quite variable but can have characteristic signs and clinical features. This review provides a comprehensive overview of the various ocular and neuro-ophthalmic manifestations of sarcoidosis, emerging diagnostic measures and approach to treatment. Read More

J Neurol Sci 2017 Aug 27;379:84-88. Epub 2017 May 27.

Neurology Department, Centro Hospitalar do Porto, Porto, Portugal; Unit for Multidisciplinary Research in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Portugal.

Introduction: Neurosarcoidosis occurs in about 5% to 15% of patients with sarcoidosis. The purpose of this study was to identify and characterize a cohort of neurosarcoidosis patients and to review the largest previously reported neurosarcoidosis case series.

Methods: This retrospective study enrolled all patients with the diagnosis of probable or definitive neurosarcoidosis according to Zajicek and Scolding criteria, followed at the neurology department of a tertiary center in Portugal from January 1989 to December 2015. Read More

Neuroepidemiology 2017 10;48(3-4):87-94. Epub 2017 Jun 10.

Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background/aims: Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting.

Methods: Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sarcoidosis from Olmsted County, Minnesota, United States from 1976 to 2013 using individual medical record review. Read More

Invest Ophthalmol Vis Sci 2017 05;58(6):BIO52-BIO60

Araim Pharmaceuticals, Tarrytown, New York, United States.

Purpose: Sarcoidosis frequently is complicated by small nerve fiber loss (SNFL), which can be quantified using corneal confocal microscopy (CCM). Prior studies suggest that the innate repair receptor agonist cibinetide reverses corneal nerve loss. This phase 2b, 28-day, randomized trial of 64 subjects with sarcoid-associated SNFL and neuropathic pain assessed the effect of cibinetide on corneal nerve fiber area (CNFA) and regenerating intraepidermal fibers (GAP-43+) as surrogate endpoints for disease modification, pain severity, and functional capacity (6-minute walk test [6MWT]). Read More

Rev Med Interne 2018 Feb 11;39(2):99-106. Epub 2017 Apr 11.

U1096, service de médecine interne, Normandie univ, UNIROUEN, 76000 Rouen, France.

Small fiber neuropathy (SFN) is still unknown. Characterised by neuropathic pain, it typically begins by burning feet, but could take many other expression. SFN affects the thinly myelinated Aδ and unmyelinated C-fibers, by an inherited or acquired mechanism, which could lead to paresthesia, thermoalgic disorder or autonomic dysfunction. Read More

Respir Med 2017 05 9;126:135-138. Epub 2017 Mar 9.

Cleveland Clinic Foundation, Respiratory Institute, Cleveland, OH, USA.

Objective: Small fiber neuropathy commonly affects patients with sarcoidosis and is often refractory to standard immunosuppressive therapies used for systemic disease. The clinical features of sarcoidosis-associated small fiber neuropathy (SSFN) and its response to medical therapy have not been described in a large population.

Methods: We performed a retrospective review of patients with SSFN seen at the Cleveland Clinic over a 4-year period. Read More

Sarcoidosis Vasc Diffuse Lung Dis 2017 9;34(3):264-268. Epub 2020 Mar 9.

Division of Environmental and Occupational Health Sciences, National Jewish Health, Denver, Colorado, Department of Medicine, National Jewish Health, Denver, CO, USA.

The 2015 annual meeting of the Americas Association of Sarcoidosis and Other Granulomatous Disorders (AASOG) was held on September 25 and 26 at the University of Colorado Anschutz Medical Campus in Aurora, CO, U.S.A. Read More

Sarcoidosis Vasc Diffuse Lung Dis 2017 28;34(2):179-183. Epub 2017 Apr 28.

University of Minnesota Departments of Ophthalmology.

To report three cases of sarcoidosis confined to the optic nerve. Chart review of clinical, laboratory, imaging, and optic nerve biopsy findings and a review of the literature. All three cases presented with progressive visual loss and showed enhancement of the intraorbital optic nerve on magnetic resonance imaging. Read More