2,449 results match your criteria Sarcoidosis Thoracic

Utility of nuclear cardiovascular imaging in the cardiac intensive care unit.

J Nucl Cardiol 2021 Jun 9. Epub 2021 Jun 9.

Cleveland Clinic Heart, Thoracic, Institute Cleveland Clinic, 9500 Euclid Ave. J1-5, Cleveland, OH, 44195, USA.

The contemporary Cardiac Intensive Care Unit (CICU) has evolved into a complex unit that admits a heterogeneous mix of patients with a wide range of acute cardiovascular diseases often complicated by multi-organ failure. Although electrocardiography (ECG) and echocardiography are well-established as first-line diagnostic modalities for assessing patients in the CICU, nuclear cardiology imaging has emerged as a useful adjunctive diagnostic modality. The versatility, safety and accuracy of nuclear imaging (e. Read More

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Adaptive immune system in pulmonary sarcoidosis - comparison of peripheral and alveolar biomarkers.

Clin Exp Immunol 2021 Jun 9. Epub 2021 Jun 9.

Respiratory Diseases and Lung Transplantation, Department of Medical and Surgical Sciences & Neurosciences, Siena University Hospital, Siena, 53100, Italy.

Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Recent research has focused on the role of autoimmunity in its development and progression. This study aimed to determine and define disturbance and distribution of T- and B-cell subsets in the alveolar and peripheral compartments. Read More

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Generalised lymphadenopathy in a patient with fever of unknown origin as a differential diagnostic challenge - case report.

J Pak Med Assoc 2021 May;71(5):1489-1492

Department of Infectious diseases, Faculty of Medical Sciences, University of Kragujevac, Serbia.

Fever of unknown origin (FUO) presents a major diagnostic challenge as it is a consequence of many infectious as well as malignant, rheumatologic and other diseases. Here we present the case of a woman with mediastinal and abdominal lymphadenopathy who was initially suspected to have lymphoproliferative disease, but our histopathologic examination revealed sarcoidosis. Sarcoidosis, especially chronic, is a rare cause of FUO, because it usually manifests as a febrile condition. Read More

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Characterization and Outcomes of SARS-CoV-2 Infection in Patients with Sarcoidosis.

Viruses 2021 05 27;13(6). Epub 2021 May 27.

Department of Autoimmune Diseases, ICMiD, Hospital Clinic, 08036 Barcelona, Spain.

To analyze the clinical characteristics and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with sarcoidosis from a large multicenter cohort from Southern Europe and to identify the risk factors associated with a more complicated infection. We searched for patients with sarcoidosis presenting with SARS-CoV-2 infection (defined according to the European Centre for Disease Prevention and Control guidelines) among those included in the SarcoGEAS Registry, a nationwide, multicenter registry of patients fulfilling the American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and Other Granulomatous Disorders 1999 classification criteria for sarcoidosis. A 2:1 age-sex-matched subset of patients with sarcoidosis without SARS-CoV-2 infection was selected as control population. Read More

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Novelties in Imaging of Thoracic Sarcoidosis.

J Clin Med 2021 May 21;10(11). Epub 2021 May 21.

Department of Diagnostic Imaging, Oncological Radiotherapy and Hematology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00168 Rome, Italy.

Sarcoidosis is a systemic granulomatous disease affecting various organs, and the lungs are the most commonly involved. According to guidelines, diagnosis relies on a consistent clinical picture, histological demonstration of non-caseating granulomas, and exclusion of other diseases with similar histological or clinical picture. Nevertheless, chest imaging plays an important role in both diagnostic assessment, allowing to avoid biopsy in some situations, and prognostic evaluation. Read More

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Sarcoidosis-Like Cancer-Associated Granulomatosis: Characteristics and a Case-Control Comparison with Sarcoidosis.

J Clin Med 2021 May 5;10(9). Epub 2021 May 5.

Service de Pneumologie et Soins Intensifs, Assistance Publique-Hôpitaux de Paris Centre, Hôpital Européen Georges Pompidou, 75015 Paris, France.

(1) Background: Systemic granulomatosis developed in a context of malignancy has already been reported. Our objective was to describe the clinical, radiological, functional, biological, and evolutive characteristics of sarcoidosis-like cancer-associated granulomatosis (SLCAG) and to compare them to those of sarcoidosis. (2) Methods: 38 patients with a biopsy-proven SLCAG developed after a diagnostic of malignancy were included. Read More

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Epidemiology of sarcoidosis in northern Spain, 1999-2019: A population-based study.

Eur J Intern Med 2021 May 25. Epub 2021 May 25.

Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain. Electronic address:

Background: The incidence of sarcoidosis varies widely worldwide. The aim of this study was to estimate the incidence of sarcoidosis in a population-based cohort from northern Spain.

Methods: Patients diagnosed with sarcoidosis at Marqués de Valdecilla University Hospital, corresponding to the central Cantabria that encompasses Santander city and the surroundings, between January 1999 and December 2019were assessed. Read More

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Patient-reported outcomes and patient-reported outcome measures in interstitial lung disease: where to go from here?

Eur Respir Rev 2021 Jun 25;30(160). Epub 2021 May 25.

Dept of Respiratory Diseases and Allergy, Centre for Rare Lung Diseases, Aarhus University Hospital, Aarhus N, Denmark.

Patient-reported outcome measures (PROMs), tools to assess patient self-report of health status, are now increasingly used in research, care and policymaking. While there are two well-developed disease-specific PROMs for interstitial lung diseases (ILD) and idiopathic pulmonary fibrosis (IPF), many unmet and urgent needs remain. In December 2019, 64 international ILD experts convened in Erice, Italy to deliberate on many topics, including PROMs in ILD. Read More

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HFA/HFSA/JHFS Position Statement on Endomyocardial Biopsy.

J Card Fail 2021 Apr 27. Epub 2021 Apr 27.

Cleveland Clinic, Cleveland OH, USA.

Endomyocardial biopsy (EMB) is an invasive procedure, globally most often used for the monitoring of heart transplant (HTx) rejection. In addition, EMB can have an important complementary role to the clinical assessment in establishing the diagnosis of diverse cardiac disorders, including myocarditis, cardiomyopathies, drug-related cardiotoxicity, amyloidosis, other infiltrative and storage disorders, and cardiac tumours. Improvements in EMB equipment and the development of new techniques for the analysis of EMB samples has significantly improved diagnostic precision of EMB. Read More

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Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy.

Eur J Heart Fail 2021 May 19. Epub 2021 May 19.

Cleveland Clinic, Cleveland, OH, USA.

Endomyocardial biopsy (EMB) is an invasive procedure, globally most often used for the monitoring of heart transplant (HTx) rejection. In addition, EMB can have an important complementary role to the clinical assessment in establishing the diagnosis of diverse cardiac disorders, including myocarditis, cardiomyopathies, drug-related cardiotoxicity, amyloidosis, other infiltrative and storage disorders, and cardiac tumours. Improvements in EMB equipment and the development of new techniques for the analysis of EMB samples have significantly improved diagnostic precision of EMB. Read More

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Clinical characteristics of sarcoidosis patients in Belgium.

Acta Clin Belg 2020 Sep 16:1-8. Epub 2020 Sep 16.

Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.

Background: Sarcoidosis is a non-caseating granulomatous disease, mostly affecting previously healthy persons in their fourth and fifth decade. In Belgium, there is a paucity of epidemiological data concerning sarcoidosis and it is unknown to what respect national data on sarcoidosis relates to the global epidemiology of the disease.

Objectives: In this cohort study we describe the patient population in an academic center of reference, serving both as a regional care center and a center for a tertiary referral. Read More

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September 2020

Case Report: A Well-Hidden Cause for Myelopathy.

Front Neurol 2021 20;12:672648. Epub 2021 Apr 20.

Department of Neurology, University Hospital Giessen and Marburg, Giessen, Germany.

Sarcoidosis is a rare, systemic inflammatory disease and can involve multiple organs, especially the lungs and lymph nodes. The nervous system is affected in <10 percent of patients, which is called neurosarcoidosis. Neurosarcoidosis can cause a multitude of symptoms and can mimic various diseases. Read More

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Pulmonary infarction caused by sarcoidosis vascular involvement: A case report.

Pathol Int 2021 Apr 26. Epub 2021 Apr 26.

Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Sarcoidosis is a systemic granulomatous disease. In pulmonary sarcoidosis, granulomatous vascular involvement is a common feature that occurs in all types of vessels, including large elastic arteries to venules, but sarcoidosis complicated with pulmonary infarction has not been reported. We report a case of a 60 years old female, who was operated on a clinical diagnosis of lung cancer, and histological examination revealed a pulmonary infarction and sarcoidosis. Read More

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Mediastinal lymphadenopathy: a practical approach.

Expert Rev Respir Med 2021 May 6:1-18. Epub 2021 May 6.

Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

: Mediastinal lymphadenopathy is secondary to various benign and malignant etiologies. There is a variation in the underlying cause in different demographic settings. The initial clue to the presence of enlarged mediastinal lymph nodes is through thoracic imaging modalities. Read More

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ATS Core Curriculum 2020. Pediatric Pulmonary Medicine.

ATS Sch 2020 Dec 30;1(4):456-475. Epub 2020 Dec 30.

Beth Israel Deaconess Medical Center, Boston, Massachusetts.

The American Thoracic Society Core Curriculum updates clinicians annually in adult and pediatric pulmonary disease, medical critical care, and sleep medicine, in a 3- to 4-year recurring cycle of topics. These topics will be presented at the 2020 International Conference. Below is the pediatric pulmonary medicine core, including pediatric hypoxemic respiratory failure; modalities in noninvasive management of chronic respiratory failure in childhood; surgical and nonsurgical management of congenital lung malformations; an update on smoke inhalation lung injury; an update on vaporizers, e-cigarettes, and other electronic delivery systems; pulmonary complications of sarcoidosis; pulmonary complications of congenital heart disease; and updates on the management of congenital diaphragmatic hernia. Read More

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December 2020

Transbronchial cryobiopsy for diagnosing parenchymal lung diseases: real-life experience from a tertiary referral center.

Sarcoidosis Vasc Diffuse Lung Dis 2021 31;38(1):e2021004. Epub 2021 Mar 31.

University of Health Sciences Turkey, Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Department of Chest Diseases, Istanbul, Turkey.

Background And Objectives: Transbronchial cryobiopsy (cryo-TBB) is increasingly being used in the diagnosis of diffuse parenchymal lung diseases (DPLD). Varying diagnostic success and complication rates have been reported. Herein we report our experience with cryo-TBB, focusing on diagnostic yield, factors affecting diagnosis, and safety. Read More

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F-fluorodeoxyglucose positron emission tomography/computed tomography imaging review of benign lesions of the thorax.

Reddy Ravikanth

World J Nucl Med 2021 Jan-Mar;20(1):7-16. Epub 2020 Oct 7.

Department of Radiology, St. John's Hospital, Kattappana, Kerala, India.

2-deoxy-2-(Fluorine-18) fluoro-D-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT) has been used exclusively to diagnose malignancies. However, increased F-FDG uptake is not always limited to malignant lesions. This imaging review demonstrates the physiological F-FDG uptake of normal structures in the thorax and illustrates many benign pathological lesions with standardized uptake value >2. Read More

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October 2020

[Sinus node dysfunction associated with cardiac sarcoidosis: A case report].

Rev Med Interne 2021 Apr 3. Epub 2021 Apr 3.

Service de cardiologie, unité de rythmologie, hôpital européen Georges-Pompidou, Université de Paris, Assistance publique-Hôpitaux de Paris, 75015 Paris, France. Electronic address:

Introduction: Sarcoidosis is a multisystemic granulomatous disease of unknown cause occurring in young adults. Cardiac sarcoidosis patients are at increased risk for atrioventricular blocks and ventricular arrhythmias. Sinus node dysfunction is scarcely reported. Read More

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Utility of FDG PET and Cardiac MRI in Diagnosis and Monitoring of Immunosuppressive Treatment in Cardiac Sarcoidosis.

Radiol Cardiothorac Imaging 2020 Aug 27;2(4):e190140. Epub 2020 Aug 27.

Department of Radiology and Diagnostic Imaging, University of Alberta Hospital, 8440 112 St NW, Edmonton, AB, Canada T6G 2B7 (R.A.C., E.P.S., J.T.A.); and Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (A.M.C.).

Purpose: To compare the contributions of cardiac MRI and PET in the diagnosis and management of cardiac sarcoidosis (CS), with particular reference to quantitative measures.

Materials And Methods: This is a retrospective, observational study of 31 patients (mean age, 45.7 years) with proven extracardiac sarcoidosis and possible CS who were investigated with fluorine 18 fluorodeoxyglucose (FDG) PET/CT and cardiac MRI. Read More

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Obliterating Airway Bronchus Sign of Occult Malignancy in Sarcoid Conglomerate Fibrotic Masses.

J Clin Imaging Sci 2021 25;11:12. Epub 2021 Feb 25.

Department of Radiology, St. Vincent's University College, Dublin, Ireland.

Sarcoidosis is a multiorgan disease which presents in up to 95% of cases with lung involvement, a proportion of which develops conglomerate fibrotic masses (CFMs). CFMs typically progressively increase in size overtime. The development of a lung malignancy within a CFM is rare and difficult to diagnose within the underlying lung fibrosis. Read More

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February 2021

Neurosarcoidosis - a patient series.

Tidsskr Nor Laegeforen 2021 03 22;141(5). Epub 2021 Mar 22.

Background: Neurosarcoidosis is a rare form of sarcoidosis that affects the nervous system. The aim of the study was to survey clinical manifestations, findings from assessments and treatment strategies for patients with neurosarcoidosis.

Material And Method: The study performed a retrospective assessment of 17 patients with definitive, probable and possible neurosarcoidosis diagnosed in the period 2008-2019 at the Department of Neurology, Haukeland University Hospital. Read More

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Pure extra-thoracic sarcoidosis: about 24 cases.

Rom J Intern Med 2021 Mar 22. Epub 2021 Mar 22.

Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia.

Introduction: Pure extra-thoracic sarcoidosis is rare and poorly characterized in the literature. Herein we present features of pure extra-thoracic sarcoidosis, in comparison with sarcoidosis with intra-thoracic involvement, in a population from the south of Tunisia.

Methods: Retrospective, descriptive and comparative study of the patients presenting systemic sarcoidosis and attending the Department of Internal Medicine at the Hedi Chaker University Hospital, Sfax, Tunisia, for 21 years, from January1996 to December2016. Read More

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The Cobblestone Heart.

Med J Malaysia 2021 03;76(2):241-244

Hospital Raja Perempuan Zainab II, Department of Medicine, Kota Bharu, Malaysia.

Sarcoidosis is a chronic, multisystem disorder. A 38 years old lady presented at Hospital Raja Perempuan Zainab II, Kota Bharu ,Malaysia with cough and breathless for 2 months and constitutional symptoms of weight loss and loss of appetite. She was initially treated as smear negative pulmonary tuberculosis for 5 months. Read More

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Sarcoidosis-Lymphoma Syndrome Presenting As Bony Vertebral Metastasis: A Case Report and Literature Review.

Cureus 2021 Feb 8;13(2):e13227. Epub 2021 Feb 8.

Neurological Surgery, Moffitt Cancer Center, Tampa, USA.

Sarcoidosis preceding a diagnosis of lymphoma has been a reported phenomenon termed sarcoidosis-lymphoma syndrome. Skeletal metastasis is extremely rare. Here, we detail a case of sarcoidosis-lymphoma syndrome presenting as a lumbar vertebral metastasis with suspected associated intracranial lesions. Read More

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February 2021

Multidisciplinary team obviates biopsy in most patients with diffuse parenchymal lung diseases-A retrospective study from India.

Clin Respir J 2021 Mar 15. Epub 2021 Mar 15.

Department of Pulmonology and Internal Medicine, Mazumdar Shaw Medical Center, Narayana Health City, Bengaluru, India.

Introduction: The inflammation and fibrosis in diffuse parenchymal lung diseases (DPLDs) in varied proportions give rise to different patterns in radiology and histopathology. The radiological pattern on CT of the thorax most often allows us to make a diagnosis with varying levels of confidence, to optimize management. With a multidisciplinary team bringing the strengths of their individual domains of knowledge, clinical, radiological, histopathological, and in many cases rheumatological, the level of confidence in making this diagnosis increases, often to the stage where the diagnosis is most often right, is concordant with the diagnosis achieved at histopathology and therefore obviates the need for lung biopsy which carries its own costs and risks of complications. Read More

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Comparison of typical and atypical computed tomography patterns regarding reversibility and fibrosis in pulmonary sarcoidosis.

Ann Thorac Med 2021 Jan-Mar;16(1):118-125. Epub 2021 Jan 14.

Department of Chest Disease, Chest Disease and Thoracic Surgery Training and Research Hospital, Health Sciences University, Izmir, Turkey.

Purpose: This study aims to investigate whether there is a significant difference between typical and atypical parenchymal patterns in the development of fibrosis, which is the most crucial factor affecting morbidity in pulmonary sarcoidosis.

Methods: In our hospital, 145 cases with Siltzbach Types 2 and 3 sarcoidoses diagnosed by clinical, radiological, and histopathologic were retrospectively investigated. Perilymphatic nodules, accompanying mosaic attenuation, and interlobular septal thickening and central peribronchovascular bunch-like thickening on high-resolution computed tomography were assessed as typical. Read More

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January 2021

Bilateral leg swelling as the presenting symptom of Löfgren syndrome in a paediatric patient: a rare presentation of a rare paediatric disease.

BMJ Case Rep 2021 Mar 4;14(3). Epub 2021 Mar 4.

Pediatric Respirology, Stollery Children's Hospital, Edmonton, Alberta, Canada

A 17-year-old previously healthy man presented with a 4-week history of progressive bilateral leg swelling with discomfort and erythema, but no signs of arthritis or erythema nodosum. An incidental finding of a query pulmonary nodule on chest X-ray prompted chest CT for further evaluation, revealing bilateral hilar and mediastinal lymphadenopathy. The patient then underwent endobronchial ultrasound and transbronchial needle aspiration biopsies of mediastinal lymph nodes. Read More

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[Pulmonary and Cardiac Sarcoidosis - Diagnosis and Therapy].

Dtsch Med Wochenschr 2021 Mar 1;146(5):335-343. Epub 2021 Mar 1.

Sarcoidosis occurs predominantly in younger adults and may involve multiple organ systems. Although classical features such as bihilar lymphadenopathy, low grade fever, fatigue, pulmonary opacities, ocular lesions and arthritis occur frequently it must be kept in mind that sarcoidosis is able to mimic virtually any other disease. A thorough and systematic diagnostic strategy is warranted since even the histological hallmark of non-caseating granulomas occurs in a variety of other granulomatous diseases and even malignancies. Read More

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Sarcoidosis Presenting as Fatigue and Weakness.

J Coll Physicians Surg Pak 2021 Feb;31(2):218-220

Department of Pulmonary Medicine, The Aga Khan University Hospital, Karachi, Pakistan.

Sarcoidosis is a systemic granulomatous disorder of unknown cause that occurs in both men and women of all races. It typically presents in patients after 20 years of age. Sarcoidosis most frequently involves the lung, but up to 30 percent of patients present with extra-thoracic manifestations. Read More

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February 2021

Clinically isolated descending thoracic aortitis in a healthy older woman: a diagnostic challenge.

BMJ Case Rep 2021 Feb 18;14(2). Epub 2021 Feb 18.

Faculty of Health and Medical Sciences, The University of Western Australia, Perth, Western Australia, Australia

A woman travelling to Australia in her early 70s presents to a regional emergency department with chest pain and associated shortness of breath. Her medical history was that of seasonal affective disorder treated with citalopram, and an allergy to ibuprofen. Subsequent CT imaging revealed aortic wall thickening and associated periaortic fluid, and a moderate pleural effusion. Read More

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February 2021