2,327 results match your criteria Sarcoidosis Thoracic


Diffuse Sarcoidosis Masquerading as Widespread Malignant Disease: A Rare Case Report and Literature Review.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620938942

James H. Quillen Veterans Affairs Medical Center, Mountain Home, TN, USA.

Sarcoidosis is a multisystem granulomatous disease commonly involving the lungs and mediastinal lymph nodes with the exact etiology being unclear. The simultaneous presence of malignant disease such as breast cancer and sarcoidosis has been reported. Sarcoidosis preceding a diagnosis of malignancy and that occurring years after treatment of malignant disease has been noted in the past. Read More

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http://dx.doi.org/10.1177/2324709620938942DOI Listing

Sarcoidosis presenting as hiccups.

Respirol Case Rep 2020 Aug 29;8(6):e00605. Epub 2020 Jun 29.

Division of Pulmonary Medicine Memorial Sloan Kettering Cancer Center New York NY USA.

Hiccups are common; however, hiccups caused by sarcoidosis have rarely been reported. An unusual case involving a patient with persistent hiccups possibly caused by hilar/mediastinal lymph node enlargement due to sarcoidosis prompted us to perform a literature search. Eight case reports relating hiccups to sarcoidosis were found and in only one case were the hiccups thought to be due to thoracic lymphadenopathy (LAD). Read More

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http://dx.doi.org/10.1002/rcr2.605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324693PMC

Evaluation of Serum Biomarkers in Patients with Sarcoidosis: Can Visfatin Be a New Biomarker for Sarcoidosis?

Turk Thorac J 2020 May;21(3):145-149

Department of Biochemical, Bağcılar Education and Research Hospital, İstanbul, Turkey.

Objectives: Sarcoidosis is a chronic systemic inflammatory disease that affects multiple organ systems. The role of biomarkers in the diagnosis and prognosis of sarcoidosis is increasing. Interest in the role of adipose tissue-mediated inflammation in the pathogenesis of inflammatory diseases has increased in recent years. Read More

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http://dx.doi.org/10.5152/TurkThoracJ.2019.180112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311147PMC

The extended utility of antifibrotic therapy in progressive fibrosing interstitial lung disease.

Expert Rev Respir Med 2020 Jun 22. Epub 2020 Jun 22.

Manchester University NHS Foundation Trust , Manchester, United Kingdom.

Introduction: The approval of two antifibrotic treatment agents for delaying disease progression in idiopathic pulmonary fibrosis (IPF), has prompted researchers to look at expanding the role of antifibrotic therapy to other fibrosing interstitial lung disease (ILD). Similarities in the pathological mechanisms that lead to the development of IPF have been implicated in other progressive fibrosing ILD (PF-ILD) such as chronic hypersensitivity pneumonitis, connective tissues disease associated ILD, sarcoidosis, occupational ILD and idiopathic non-specific interstitial pneumonia (iNSIP). This has prompted the rationale to use antifibrotic therapy to target similar molecular pathways in these diseases. Read More

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http://dx.doi.org/10.1080/17476348.2020.1784730DOI Listing

Massive pericardial effusion causing cardiac tamponade accompanied by elevated CA-125 and thoracic lymphadenopathy in sarcoidosis: a case report.

Int J Surg Case Rep 2020 Jun 13;72:355-360. Epub 2020 Jun 13.

Scientific Research Institute of Heart Surgery and Organ Transplantation, Bishkek, Kyrgyzstan.

Introduction: Pericardial effusion and cardiac tamponade are rare manifestations of cardiac sarcoidosis. This is a first case report that describes a patient with severe pericardial effusion and signs of cardiac tamponade with elevated carbohydrate antigen 125 (CA-125) levels, enlarged pericardial (PLN) and mediastinal lymph nodes (MLN), histologically confirmed as sarcoidosis.

Presentation Of Case: A 51-year-old female patient was admitted with complaints of sickness, shortness of breath on minimal exertion, swelling in lower extremities, and heaviness in right upper abdomen. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306529PMC

Sarcoid-like reaction in lymphadenopathy associated with superficial esophageal squamous cell carcinoma.

Clin J Gastroenterol 2020 Jun 9. Epub 2020 Jun 9.

Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.

Correctly distinguishing metastasis and sarcoid-like reaction in patients with mediastinal lymphadenopathy is clinically important in esophageal cancer. A patient was a 52-year-old Japanese woman with superficial esophageal squamous cell carcinoma and rare case of sarcoid-like reaction. The patient was admitted with pharyngeal discomfort and an upper gastrointestinal endoscopy detected a superficial tumor in the middle thoracic esophagus. Read More

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http://dx.doi.org/10.1007/s12328-020-01156-xDOI Listing

TREM-1 and TREM-2 Expression on CD14 Cells in Bronchoalveolar Lavage Fluid in Pulmonary Sarcoidosis and Hypersensitivity Pneumonitis in the Context of T Cell Immune Response.

Mediators Inflamm 2020 14;2020:9501617. Epub 2020 May 14.

Institute of Immunology, Faculty of Medicine Comenius University, Bratislava, Slovakia.

Background: Sarcoidosis and hypersensitivity pneumonitis (HP) are immunologically mediated processes caused by hypersensitivity reaction accompanied by similar features including lymphocytic alveolitis and granuloma formation. Recent studies describe the role of TREM receptors in T cell activation, differentiation, and granuloma formation. Alveolar macrophages activation via TREM receptors may be the key factor mediating subsequent immune response. Read More

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http://dx.doi.org/10.1155/2020/9501617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244974PMC

A Comprehensive and Contemporary Review on Immunosuppression Therapy for Heart Transplantation.

Curr Pharm Des 2020 Jun 3. Epub 2020 Jun 3.

Heart Transplantation Unit, Cardiology Department, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre. Brazil.

Heart transplantation is the standard of therapy for patients with end-stage heart disease. Since the first human-to-human heart transplantation, performed in 1967, advances in organ donation, surgical techniques, organ preservation, perioperative care, immunologic risk assessment, immunosuppression agents, monitoring of graft function and surveillance of long-term complications have drastically increased recipient survival. However, there are yet many challenges in the modern era of heart transplantation in which immunosuppression may play a key role for further advances in the field. Read More

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http://dx.doi.org/10.2174/1381612826666200603130232DOI Listing

Clinical characteristics and organ system involvement in sarcoidosis: comparison of the University of Minnesota Cohort with other cohorts.

BMC Pulm Med 2020 Jun 1;20(1):155. Epub 2020 Jun 1.

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Univesity of Minnesota Medical School, Minneapolis, USA.

Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Clinical cohort studies of different populations are important to understand the high variability in clinical presentation and disease course of sarcoidosis. The aim of the study is to evaluate clinical characteristics, including organ involvement, pulmonary function tests, and laboratory parameters, in a sarcoidosis cohort at the University of Minnesota. Read More

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http://dx.doi.org/10.1186/s12890-020-01191-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268634PMC

Histological differences between sarcoidosis and lung cancer-related sarcoid reaction.

Respir Investig 2020 May 29. Epub 2020 May 29.

Department of Respiratory Medicine, Nishi Fukuoka Hospital, Fukuoka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.resinv.2020.04.003DOI Listing

Which patients are SaPHe in sarcoidosis-associated pulmonary hypertension?

Eur Respir J 2020 May 14;55(5). Epub 2020 May 14.

Dept of Medicine, Division of Respirology, University of Calgary, Calgary, AB, Canada

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http://dx.doi.org/10.1183/13993003.00700-2020DOI Listing

Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies: Guideline From the College of American Pathologists in Collaboration With the American College of Chest Physicians, Association for Molecular Pathology, American Society of Cytopathology, American Thoracic Society, Pulmonary Pathology Society, Papanicolaou Society of Cytopathology, Society of Interventional Radiology, and Society of Thoracic Radiology.

Arch Pathol Lab Med 2020 May 13. Epub 2020 May 13.

From the Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston (Dr Roy-Chowdhuri); Thoracic Surgery and Interventional Pulmonology, Swedish Cancer Institute, Seattle, Washington (Dr Gilbert); the Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania (Dr Dacic); the Department of Pathology, PeaceHealth Southwest Medical Center, Vancouver, Washington (Dr Ghofrani); the Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland (Dr Illei); the Department of Pathology and Anatomic Sciences, University of Missouri, Columbia (Dr Layfield); the Department of Radiology, Keck Medical Center of the University of Southern California, Los Angeles (Dr Lee); the Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio (Dr Michael); Memorial Pathology Consultants, PA, Houston, Texas (Dr Miller); the Department of Radiology, Capital Regional Medical Center, Tallahassee, Florida (Dr Mitchell); the Department of Interventional and Vascular Radiology, Cooley Dickinson Hospital, Northampton, Massachusetts (Dr Nikolic); the Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York (Dr Nowak); the Division of Pulmonary and Critical Care, Medical University of South Carolina, Charleston (Dr Pastis); the Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Dr Rauch); the Department of Radiology, Massachusetts General Hospital, Boston (Dr Sharma); the Methodology Consultant, Ontario, Canada (Dr Souter); the Departments of Governance Services (Ms Billman) and Surveys (Ms Thomas), College of American Pathologists, Northfield, Illinois; the Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (Dr VanderLaan); the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Voss); the Division of Pulmonary, Allergy and Critical Care, Duke University School of Medicine, Durham, North Carolina (Dr Wahidi); and the Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD (Dr Yarmus).

Context.—: The need for appropriate specimen use for ancillary testing has become more commonplace in the practice of pathology. This, coupled with improvements in technology, often provides less invasive methods of testing, but presents new challenges to appropriate specimen collection and handling of these small specimens, including thoracic small biopsy and cytology samples. Read More

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http://dx.doi.org/10.5858/arpa.2020-0119-CPDOI Listing

Pleural Sarcoidosis and Occult Lymphatic Anthracosis: An Unusual Symptomatic Association.

Eur J Case Rep Intern Med 2020 17;7(5):001479. Epub 2020 Mar 17.

Department of Internal Medicine, Hospital Garcia de Orta, Almada, Portugal.

Sarcoidosis is a chronic multisystemic inflammatory disease of unknown aetiology. Virtually any organ or system can be involved, resulting in a wide range of clinical presentation. Pleural sarcoidosis is rare. Read More

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http://dx.doi.org/10.12890/2020_001479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213820PMC

Transbronchial lung cryobiopsy guided by radial mini-probe endobronchial ultrasound in interstitial lung diseases - a multicenter prospective study.

Adv Respir Med 2020 ;88(2):123-128

Endoscopy Unit, Pulmonary Hospital, Zakopane, Polan.

Introduction: Transbronchial lung cryobiopsy (TBLC) is commonly used in diagnosing interstitial lung diseases (ILDs). Ageneral anesthesia with endotracheal intubation, balloon blockers and fluoroscopy control is the most common modality. Simplifying the procedure without decreasing it's safety could result in wider use. Read More

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http://dx.doi.org/10.5603/ARM.2020.0086DOI Listing
January 2020

Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline.

Am J Respir Crit Care Med 2020 04;201(8):e26-e51

The diagnosis of sarcoidosis is not standardized but is based on three major criteria: a compatible clinical presentation, finding nonnecrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative causes of granulomatous disease. There are no universally accepted measures to determine if each diagnostic criterion has been satisfied; therefore, the diagnosis of sarcoidosis is never fully secure. Systematic reviews and, when appropriate, meta-analyses were performed to summarize the best available evidence. Read More

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http://dx.doi.org/10.1164/rccm.202002-0251STDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159433PMC

Diagnostic yield of rapid on-site evaluation transbronchial needle aspiration versus conventional transbronchial needle aspiration: a single center experience.

Monaldi Arch Chest Dis 2020 Apr 15;90(1). Epub 2020 Apr 15.

Department of Thoracic Surgery, Monaldi Hospital, A.O. dei Colli, Naples.

Trans-bronchial needle aspiration allows lymph node sampling in several thoracic conditions; the ability of Rapid On-Site Evaluation (ROSE) to predict the final diagnosis in this setting has not been well characterized. We performed a retrospective study to establish the utility of ROSE in the diagnosis of thoracic diseases with mediastinal lymph node involvement. We retrospectively reviewed 297 patients with hilar-mediastinal lymph node enlargement detected at CT scan from January 2013 to April 2016. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1144DOI Listing

Morphological Patterns of Sarcoidosis and Clinical Outcome: Retrospective Analysis through a Multidisciplinary Approach.

Diagnostics (Basel) 2020 Apr 11;10(4). Epub 2020 Apr 11.

Radiology Unit 1, Department of Medical Surgical Sciences and Advanced Technologies "GF Ingrassia"-University Hospital "Policlinico-Vittorio Emanuele", University of Catania, 95123 Catania, Italy.

The aim of this work was to verify the correlations between different pulmonary morphological patterns and functional outcomes in sarcoidosis patients, using a validated score for the comparison between the high-resolution computed tomography (HRCT) of patients belonging to different imaging patterns. From the electronic database of the reference center for interstitial lung diseases of our University Hospital, we retrospectively selected 55 patients with a diagnosis of sarcoidosis according to the American Thoracic Society (ATS) criteria; we evaluated the initial HRCT examination and pulmonary function tests collected at baseline and after a year. Patients were divided into typical (48% of patients) and atypical (52%) HRCT patterns, and a computer tomography activity score (CTAS) was associated with each HRCT appearance detected; clinical history, impact of therapy, and extra-thoracic locations were also considered. Read More

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http://dx.doi.org/10.3390/diagnostics10040212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235878PMC

Subcutaneous sarcoidosis with thoracic involvement: A very rare presentation of the disease.

Respir Med Case Rep 2020 26;30:101041. Epub 2020 Mar 26.

Abderrahmane Mami Hospital of Thoracic diseases. Department I, 2080, Ariana, Tunis, Tunisia.

Subcutaneous sarcoidosis is a very rare manifestation of sarcoidosis and its association with parenchymal lung involvement is rarer. We report the twentieth case in the literature published on PubMed. It is the case of a 61-year-old caucasian, non-smoker lady, who presented to a dermatology department with a 7-month history of asthenia, anorexia, weight loss, fever, exertion dyspnea, dry cough, arthralgia of the large joints and non-tender multiple subcutaneous tumefactions. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139128PMC

[When should a PET/CT be requested in sarcoidosis?]

Rev Med Chil 2019 Oct;147(10):1308-1314

Departamento de Imágenes, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile.

Sarcoidosis is a multisystemic disease of variable course that mainly affects thoracic lymph nodes and lung parenchyma. However, any organ can be involved. There is no single test for the definitive diagnosis or a precise method to evaluate the course of the disease. Read More

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http://dx.doi.org/10.4067/s0034-98872019001001308DOI Listing
October 2019

Ustekinumab-induced Sarcoidosis in a Patient with Psoriatic Arthritis.

Curr Drug Saf 2020 ;15(2):163-166

Ege University Faculty of Medicine, Department of Internal Medicine, Izmir, Turkey.

Background: Psoriatic Arthritis (PsA) is a chronic inflammatory disease that may affect different joints. Sarcoidosis is a Th-1 cell-related chronic granulomatous disease characterized by non-caseating granuloma formation. The coexistence of both the diseases is a rare entity. Read More

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http://dx.doi.org/10.2174/1574886315666200316113312DOI Listing
January 2020

PET/Computed Tomography in Pulmonary and Thoracic Inflammatory Diseases (Including Cardiac Sarcoidosis): The Current Role and Future Promises.

PET Clin 2020 Apr;15(2):163-173

Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, Mumbai 400012, India; Homi Bhabha National Institute, Mumbai 400094, India. Electronic address:

F-fluorodeoxyglucose PET/computed tomography (CT) can play a valuable adjunct role in initial and post-treatment assessment of thoracic and pulmonary inflammatory disorders and is particularly helpful when the conventional biomarkers and anatomical imaging are non-contributory or inconclusive. PET/CT can potentially help in chronic obstructive pulmonary disease (COPD). Quantitative regional parameters of inflammation, perfusion, and ventilation estimated by PET/CT have the potential to cause a paradigm shift in the management of COPD. Read More

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http://dx.doi.org/10.1016/j.cpet.2019.11.008DOI Listing

Lymphoma, a great imitator in neurology.

J Clin Neurosci 2020 Mar 18;73:308-310. Epub 2020 Feb 18.

Department of Neurology, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy VIC 3065, Australia.

The title "great imitator" refers to conditions which can cause varied manifestations and mimic many diseases. Lymphoma is worthy of this title. We describe three cases of lymphoma in which lymphoma mimicked other diseases causing neurological dysfunction, specifically sarcoidosis, vasculitis and infection respectively. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.02.001DOI Listing

Pituitary stalk enlargement in adults.

Neuroendocrinology 2020 Feb 20. Epub 2020 Feb 20.

Pathologies involving the pituitary stalk are generally revealed by the presence of diabetes insipidus (DI). The availability of MRI provides a major diagnostic contribution by enabling visualization of the site of the culprit lesion, especially when it is small. However, when only an enlarged pituitary stalk is found, the etiological workup may be difficult, particularly because the biopsy of the stalk is difficult, harmful and often not contributive. Read More

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http://dx.doi.org/10.1159/000506641DOI Listing
February 2020

Orbital Sarcoidosis in a High TB Endemic Country - A Case Series from South India.

Ocul Immunol Inflamm 2020 Feb 19:1-6. Epub 2020 Feb 19.

Department of Orbit & Oculoplasty, Vittala International Institute of Ophthalmology & Prabha Eye clinic and Research center, Bangalore, India.

: We report a series of orbital sarcoid in a south Indian patient population and their outcome.: Retrospective interventional case series.: Eleven out of 144cases of biopsy-proven sarcoidosis had orbital involvement. Read More

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http://dx.doi.org/10.1080/09273948.2019.1707235DOI Listing
February 2020

Lung cancer in never smokers: The role of different risk factors other than tobacco smoking.

Crit Rev Oncol Hematol 2020 Apr 31;148:102895. Epub 2020 Jan 31.

Hospital San Juan de Dios, San José, Costa Rica. Electronic address:

Lung cancer (LC), the leading cause of cancer-related deaths worldwide, is a complex and highly heterogeneous disease. Additional to its biological complexity, LC patients are often confronted with a high degree of stigma, mostly from the association of the disease with tobacco. Nonetheless, a proportion of LC patients are never-smokers, a population which we are beginning to comprehensively explore. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102895DOI Listing

Acute exacerbation of idiopathic pulmonary fibrosis: international survey and call for harmonisation.

Eur Respir J 2020 Apr 3;55(4). Epub 2020 Apr 3.

Dept of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus C, Denmark.

Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is an often deadly complication of IPF. No focussed international guidelines for the management of AE-IPF exist. The aim of this international survey was to assess the global variability in prevention, diagnostic and treatment strategies for AE-IPF. Read More

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http://dx.doi.org/10.1183/13993003.01760-2019DOI Listing

Breaking hearts and taking names: A case of sarcoidosis related effusive-constrictive pericarditis.

Respir Med 2020 Mar 23;163:105879. Epub 2020 Jan 23.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:

Introduction: Pericardial involvement of sarcoidosis is a rare cause for acute heart failure, and usually occurs as a result of the development of a pericardial effusion leading to cardiac tamponade. Even rarer still, is the manifestation of constrictive pericarditis. We report a case of sarcoidosis with lung, pleural, and pericardial involvement with effusive-constrictive pericarditis leading to cardiac tamponade. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.105879DOI Listing

Granuloma in the explanted lungs: Infectious causes and impact on post-lung transplant mycobacterial infection.

Transpl Infect Dis 2020 Jun 26;22(3):e13262. Epub 2020 Feb 26.

Division of Infectious Diseases, Department of Medicine, Multi-Organ Transplant Program, University of Toronto, TO, Ontario, Canada.

Introduction: The significance of granuloma in explanted lungs of lung transplant recipients (LTR) on the development of post-transplant mycobacterial infection is unclear.

Methods: A retrospective review comparing LTRs and heart-lung transplant (H-LTR) recipients with granuloma in the explanted lungs between 2000 and 2012 (excluding those LTRs with granuloma due to sarcoidosis) and LTRs or H-LTRs without granuloma. Patients were followed for 2 years post-transplant. Read More

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http://dx.doi.org/10.1111/tid.13262DOI Listing

Diagnosis issues in sarcoidosis.

Respir Med Res 2020 Mar 28;77:37-45. Epub 2019 Oct 28.

Inserm UMR 1272, université Paris 13, 93000 Bobigny, France; Service de pneumologie, hôpital Avicenne, AP-HP, 93000 Bobigny, France.

Multiple problems may be encountered during the diagnosis of sarcoidosis: at first diagnose sarcoidosis in an appropriate clinical setting, secondly, identify any manifestation to be linked to sarcoidosis at diagnosis work-up and during evolution; thirdly, recognize "danger" in sarcoidosis and parasarcoidosis syndromes, and finally, diagnose sarcoidosis recovery. Diagnosis is often delayed as presentation may be diverse, non-specific, or atypical. Diagnosis of sarcoidosis is based on three criteria: a compatible presentation; evidence of non-caseating granulomas and exclusion of any alternative diagnosis. Read More

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http://dx.doi.org/10.1016/j.resmer.2019.09.002DOI Listing

Hybrid Imaging in Evaluation of Abdominal Sarcoidosis.

Curr Med Imaging Rev 2019 ;15(1):26-31

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Objective: To determine the prevalence of abdominal involvement, distribution pattern and evaluate role of hybrid molecular imaging in patients with abdominal sarcoidosis.

Methods: Between January 2010 and December 2011, 98 patients with chronic sarcoidosis and presence of prolonged symptoms or other findings suggestive of active disease were referred to FDG PET/CT examination. Active disease was found in 82 patients, and they all were screened for the presence of abdominal sarcoidosis on FDG PET/CT. Read More

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http://dx.doi.org/10.2174/1573405614666180531111616DOI Listing
January 2019

[Lung Cancer Accompanied by Sarcoidosis with Mediastinal and Bilateral Hilar Lymphadenopathy;Report of a Case].

Kyobu Geka 2020 Jan;73(1):72-75

Department of Thoracic Surgery, Iwate Prefectural Isawa Hospital, Oshu, Japan.

A 64-year-old woman with complete atrioventricular block caused by sarcoidosis was emergently placed a pacemaker. A 10 mm nodule in the left upper lobe of the lung and the mediastinal and bilateral hilar lymphadenopathy was detected through chest computed tomography. To establish the diagnosis, resection of the tumor and #4L was performed. Read More

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January 2020

Tubulointerstitial nephritis due to sarcoidosis: Clinical, laboratory, and histological features and outcome in a cohort of 24 patients.

Saudi J Kidney Dis Transpl 2019 Nov-Dec;30(6):1276-1284

Department of Nephrology; Laboratory Department of Kidney Transplantation, Immunology and Immunopathology (LR03SP01), Charles Nicolle Hospital, Tunis, Tunisia.

Renal involvement is rare in systemic sarcoidosis. Among renal manifestations, tubulointerstitial nephritis (TIN) is the most commonly reported finding. We conducted the current study to investigate the clinical, laboratory, and histological features and to analyze the outcome of TIN due to sarcoidosis. Read More

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http://dx.doi.org/10.4103/1319-2442.275471DOI Listing
January 2020

Assessing the qualitative and quantitative impacts of simple two-class vs multiple tissue-class MR-based attenuation correction for cardiac PET/MR.

J Nucl Cardiol 2020 Jan 2. Epub 2020 Jan 2.

Translational and Molecular Imaging Institute, Leon and Norma Hess Center for Science and Medicine, Icahn School of Medicine at Mount Sinai, One Gustave Levy Pl, 1470 Madison Ave, TMII - 1st floor, New York, NY, 10029, USA.

Background: Hybrid PET/MR imaging has significant potential in cardiology due to its combination of molecular PET imaging and cardiac MR. Multi-tissue-class MR-based attenuation correction (MRAC) is necessary for accurate PET quantification. Moreover, for thoracic PET imaging, respiration is known to lead to misalignments of MRAC and PET data that result in PET artifacts. Read More

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http://dx.doi.org/10.1007/s12350-019-02002-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329599PMC
January 2020

An Uncommon Coexistence of Sarcoidosis and Cutaneous Leukocytoclastic Vasculitis in an Adult.

Indian J Dermatol 2019 Nov-Dec;64(6):486-489

Chest Diseases Clinic, Respiratory Intensive Care Unit, Istanbul Süreyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Health Sciences University, Istanbul, Turkey.

The skin is the second most commonly involved organ after pulmonary system in sarcoidosis, a multisystemic granulomatous disease. Cutaneous small-vessel vasculitis (leukocytoclastic vasculitis [LCV]) is a disorder characterized by neutrophilic inflammation of small blood vessels. Although the skin is the organ where LCV is seen most frequently, extracutaneous involvements are also seen. Read More

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http://dx.doi.org/10.4103/ijd.IJD_291_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862359PMC
January 2020

Cutaneous sarcoidosis: clinico-epidemiological profile of 72 patients at a tertiary hospital in São Paulo, Brazil.

An Bras Dermatol 2020 Jan - Feb;95(1):57-62. Epub 2019 Nov 30.

Dermatology Department, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Background: Sarcoidosis is a multisystem disease of unknown cause that is characterized by the presence of granulomas in various organs. Cutaneous involvement is common and the reported incidence has varied from 9% to 37%. Studies on cutaneous sarcoidosis in Brazil are lacking. Read More

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http://dx.doi.org/10.1016/j.abd.2019.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058863PMC

Common variable immunodeficiency presenting as sarcoidosis in a 9-year-old child.

Int J Rheum Dis 2020 Mar 19;23(3):448-453. Epub 2019 Dec 19.

Rheumatology Unit, Anna Meyer Children's Hospital, Florence, Italy.

Background: Granulomatous diseases are a heterogeneous group of conditions characterized by an inflammatory infiltrate with a core of macrophages, epithelioid, giant cells and a corona of fibroblasts and lymphocytes. They are associated with a wide range of disorders such as mycobacterial and fungal infections, neoplasms, immunodeficiencies and systemic inflammatory disorders as sarcoidosis.

Case Report: We report the case of a previously healthy 9-year-old male child who presented with persistent cough, diffuse lymphadenopathy, enlargement of liver and spleen and protracted fever. Read More

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http://dx.doi.org/10.1111/1756-185X.13775DOI Listing

Sarcoidosis with multiorgan involvement.

Postgrad Med J 2019 Dec 19. Epub 2019 Dec 19.

Department of Pathology, Suratthani Hospital, Surat Thani, Surat Thani, Thailand.

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http://dx.doi.org/10.1136/postgradmedj-2019-137219DOI Listing
December 2019

Regulatory T Cells in Respiratory Health and Diseases.

Pulm Med 2019 20;2019:1907807. Epub 2019 Nov 20.

Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Respiratory diseases compromise the health of millions of people all over the world and are strongly linked to the immune dysfunction. CD4+FOXP3+ T regulatory cells, also known as Tregs, have a central role maintaining tissue homeostasis during immune responses. Their activity and clinical impact have been widely studied in different clinical conditions including autoimmune diseases, inflammatory conditions, and cancer, amongst others. Read More

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http://dx.doi.org/10.1155/2019/1907807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886321PMC

Mycobacterium arosiense, an unexpected cause of osteomyelitis in a patient with sarcoidosis: a case report.

BMC Infect Dis 2019 Nov 26;19(1):994. Epub 2019 Nov 26.

Department of infectious Diseases, Rigshospitalet, Copenhagen, Denmark.

Background: Nontuberculous mycobacteria belonging to the Mycobacterium avium complex are recognized as opportunistic pathogens to humans. Mycobacterium arosiense is one of the novel members of the Mycobacterium avium complex. The organism has only rarely been reported in human clinical cases and may be routinely misidentified. Read More

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http://dx.doi.org/10.1186/s12879-019-4638-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878624PMC
November 2019

An Uncommon Presentation of Sarcoidosis with Ground-Glass Opacities.

Am J Respir Crit Care Med 2020 04;201(8):e54-e55

Pneumology, Mediterranean Institute for Transplantation and Advanced Specialized Therapies, IRCCS ISMETT, Palermo, Italy.

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http://dx.doi.org/10.1164/rccm.201906-1229IMDOI Listing

Pediatric Sarcoidosis: A Review with Emphasis on Early Onset and High-Risk Sarcoidosis and Diagnostic Challenges.

Diagnostics (Basel) 2019 Oct 25;9(4). Epub 2019 Oct 25.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2B7, Canada.

Sarcoidosis is a non-necrotizing granulomatous inflammatory syndrome with multisystemic manifestations. We performed a systematic review of sarcoidosis in the pediatric population with particular emphases on early onset sarcoidosis, high-risk sarcoidosis, and newly reported or unusual sarcoid-related diseases. Blau Syndrome and early onset sarcoidosis/ BS-EOS are seen in children younger than five years old presenting with extra-thoracic manifestations but usually without lymphadenopathy and/or pulmonary involvement. Read More

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http://dx.doi.org/10.3390/diagnostics9040160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963233PMC
October 2019

Sarcoidosis presenting pulmonary subsolid nodules that mimic lung adenocarcinoma in a patient with history of uveitis and arrhythmia: a case report.

Ann Transl Med 2019 Sep;7(18):496

Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Sarcoidosis is an idiopathic systemic granulomatous disorder that can involve any organ, although the lung is the most commonly affected site; moreover, it may affect multiple organs simultaneously or serially over a long time span. Diagnosing sarcoidosis can be a challenge in cases presenting an isolated extra-thoracic lesion at the early stage of disease. Pulmonary nodular lesion, a rare radiologic finding, may also lead to delayed diagnosis of sarcoidosis. Read More

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http://dx.doi.org/10.21037/atm.2019.08.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803198PMC
September 2019

Clinical Reasoning: A 65-year-old man with asymmetric weakness and paresthesias.

Neurology 2019 11;93(19):856-861

From the Department of Neurology, University of Arkansas for Medical Sciences, Little Rock.

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http://dx.doi.org/10.1212/WNL.0000000000008444DOI Listing
November 2019

Combined application of angiotensin converting enzyme and chitotriosidase analysis improves the laboratory diagnosis of sarcoidosis.

Clin Chim Acta 2020 Jan 28;500:155-162. Epub 2019 Oct 28.

Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, 22 Moricz Zsigmond str., H-4032 Debrecen, Hungary. Electronic address:

Establishing the diagnosis of sarcoidosis most often requires biopsy and histopathologic evaluation, since there is no single marker with sufficient specificity and sensitivity for the disease. Our aims were to determine and compare the diagnostic accuracies of several potential biomarkers and to develop a combined biomarker analysis tool for the diagnosis of sarcoidosis. 133 healthy individuals and 104 patients with suspected sarcoidosis and diagnostic thoracic surgery were enrolled into this study. Read More

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http://dx.doi.org/10.1016/j.cca.2019.10.010DOI Listing
January 2020

Is mediastinoscopy an effective diagnostic method in mediastinal area evaluation in pediatric patients?

Asian J Surg 2020 Jun 24;43(6):690-695. Epub 2019 Oct 24.

Department of Thoracic Surgery, Faculty of Medicine, University of Erciyes, Kayseri, Turkey.

Background: The purpose of the study was to discuss the effectiveness of mediastinoscopy for pediatric patients as the use of EBUS-EUS (Endobronchial Ultrasound-Endoscopic Ultrasound) has replaced mediastinoscopy for adult patients in evaluation of the mediastinal area.

Methods: The records of patients subject to cervical and anterior mediastinoscopy at our clinic from January 1, 2000 to June 1, 2019 were examined and patients aged 18 years or less were included in the study. Data were acquired on the demographic characteristics of the patients, type of surgery, complications, operation times, and histopathologic diagnoses. Read More

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http://dx.doi.org/10.1016/j.asjsur.2019.09.012DOI Listing

The Central Nervous System Effects and Mimicry of Common Variable Immunodeficiency (CVID): A Case Report with Literature Review.

Case Rep Rheumatol 2019 29;2019:7623643. Epub 2019 Sep 29.

Rheumatology, Beaumont Hospital, Royal Oak 48073, MI, USA.

There is a scarceness of information on the central nervous system effects of common variable immunodeficiency (CVID). A 30-year-old woman with a history of recurrent upper respiratory infections, vitiligo, and immune thrombocytopenic purpura presented with right-sided numbness. Magnetic resonance imaging (MRI) of the thoracic spine revealed a signal hyperintensity. Read More

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http://dx.doi.org/10.1155/2019/7623643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791247PMC
September 2019
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Endobronchial ultrasound-guided intranodal forceps biopsy (EBUS-IFB)-technical review.

J Thorac Dis 2019 Sep;11(9):4049-4058

Division of Pulmonary, Critical Care Medicine, Washington University Hospital, St Louis, MO, USA.

Endobronchial ultrasound (EBUS) and transbronchial needle aspiration (TBNA) have changed the landscape of pulmonology. Mediastinal structures beyond the confines of airway walls are visualized in real-time with EBUS, leading to improved accuracy of tissue sampling and diagnostic yield. With the development of various needle sizes ranging from 25-G to 19-G, the sampling of lymph nodes is becoming easier and more commonplace. Read More

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http://dx.doi.org/10.21037/jtd.2019.08.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790451PMC
September 2019
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Emerging phenotypes of sarcoidosis based on 18F-FDG PET/CT: a hierarchical cluster analysis.

Expert Rev Respir Med 2020 Feb 29;14(2):229-238. Epub 2019 Oct 29.

Nuclear Medicine Division, Foundation for Biomedical Research of the Academy of Athens, Athens, Greece.

: In sarcoidosis, the definition of organ involvement with traditional means appears laborious and somewhat controversial, and phenotyping by the above overlapping. F-FDG PET/CT defines disease extent by activity more precisely, and may result in a better understanding of sarcoidosis disease behavior and phenotypes expression. We hypothesized that F-FDG PET/CT could add in the phenotyping of sarcoidosis patients by unveiling in detail sites of involvement even in clinically and physiologically silent disease. Read More

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http://dx.doi.org/10.1080/17476348.2020.1684902DOI Listing
February 2020

Finger clubbing and cirrhosis in a sarcoidosis patient.

Monaldi Arch Chest Dis 2019 Oct 18;89(3). Epub 2019 Oct 18.

Department of Internal Medicine Medicine, Cerrahpasa Medical Faculty, Istanbul Cerrahpasa University.

Sarcoidosis is a multisystem granulomatous inflammatory disorder frequently affecting the lungs, but also the liver, along with cirrhosis and portal hypertension occurring in less than 1% of the patients. A 56-year-old female presented with dyspnea, abdominal and leg swelling. Physical examination revealed finger clubbing, ascites and pretibial edema. Read More

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http://dx.doi.org/10.4081/monaldi.2019.1141DOI Listing
October 2019
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Sarcoidosis Presenting as a Right Paraesophageal Mass Abutting the Left Atrium.

Cureus 2019 Aug 16;11(8):e5403. Epub 2019 Aug 16.

Internal Medicine, Largo Medical Center, Largo, USA.

We herein report a unique case of sarcoidosis in a 44-year-old Caucasian female. The patient was initially evaluated for hematochezia and diagnosed with diverticulitis after computed tomography (CT) scan of the abdomen and pelvis. This imaging also incidentally showed a large mass abutting the esophagus. Read More

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http://dx.doi.org/10.7759/cureus.5403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793595PMC
August 2019
3 Reads