2,198 results match your criteria Sarcoidosis Thoracic


The role of mediastinoscopy in the diagnosis of thoracic disease: 107-case analysis.

Med Glas (Zenica) 2019 Aug 1;16(2). Epub 2019 Aug 1.

Department of Thoracic Surgery, School of Medicine, Canakkale Onsekiz Mart University, Turkey.

Aim To evaluate the efficacy, safety and feasibility of mediastinoscopy in 107 cases with mediastinal lesions that could not be diagnosed histopathologically with other methods. Methods A total of 107 cases (73 males, 34 females; mean age 57.4, range 30-88 years) with mediastinal lymphadenopathy, who underwent mediastinoscopy between 12 September 2012 and 29 November 2018 were examined retrospectively. Read More

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http://dx.doi.org/10.17392/1001-19DOI Listing

Correlation between the Diagnostic Yield from the Bronchoalveolar Lavage Fluid Analysis and Clinicoradiological Findings in Sarcoidosis.

Turk Thorac J 2019 Apr 9. Epub 2019 Apr 9.

Clinic of Pulmonology, University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey.

Objectives: The diagnosis of sarcoidosis is frequently challenging, requiring a search for less invasive, more reliable diagnostic methods. The bronchoalveolar lavage fluid (BALF) analysis has been used in the differential diagnosis of sarcoidosis for many years with a wide sensitivity and specificity rates. The objective of the study is to investigate whether diagnostic performance of the BALF analysis is altered by clinicoradiological findings of patients with sarcoidosis. Read More

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http://turkthoracj.org/eng/makale/1107/154/Full-Text
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http://dx.doi.org/10.5152/TurkThoracJ.2018.180140DOI Listing
April 2019
2 Reads

Comprehensive Evaluation of the Factors Affecting Plasma Circulating Cell-Free DNA Levels and Their Application in Diagnosing Nonsmall Cell Lung Cancer.

Genet Test Mol Biomarkers 2019 Apr;23(4):270-276

1 Department of Clinical Pharmacology Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China.

Aims: Circulating cell-free DNA (ccfDNA) is a valuable biomarker, but the ccfDNA levels are influenced by variations that occur during sample processing. The feasibility of using ccfDNA as a diagnostic biomarker requires further examination.

Materials And Methods: We established a real-time PCR assay with an external standard to comprehensively evaluate the factors affecting ccfDNA levels, including the extraction kit used, freeze-thaw stability, and stability of delayed extraction. Read More

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http://dx.doi.org/10.1089/gtmb.2018.0106DOI Listing

Sarcoidosis in the UK: insights from British Thoracic Society registry data.

BMJ Open Respir Res 2019 18;6(1):e000357. Epub 2019 Feb 18.

Department of Respiratory Medicine, Hammersmith Hospital, London, UK.

Introduction: The British Thoracic Society Sarcoidosis Registry allows physicians to record clinical data after gaining written consent from patients. The registry's aim is to phenotype sarcoidosis in the UK.

Methods: Between February 2013 and July 2017, demographic details for 308 patients (with complete clinical data for 205 patients) presenting to 24 UK hospitals were recorded. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424275PMC
February 2019
1 Read

Unusual presentation of Castleman's disease mimicking lung cancer.

Respirol Case Rep 2019 May 14;7(4):e00416. Epub 2019 Mar 14.

Division of Pulmonary and Critical Care, Department of Internal Medicine Tri-Service General Hospital, National Defense Medical Center Taipei Taiwan.

Castleman's disease (CD) is an uncommon lymphoproliferative disorder characterized as either unicentric or multicentric presentation based on the involving sites. The most frequent presentation of CD is a solitary mediastinal mass. We reported a patient with a history of heavy smoking with particular image features of CD, which presented as mediastinal lymphadenopathy and peribronchovascular interstitial thickening mimicking lung cancer or sarcoidosis initially. Read More

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http://dx.doi.org/10.1002/rcr2.416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417363PMC
May 2019
1 Read

Endobronchial ultrasound-guided transbronchial needle aspiration in sarcoidosis: Beyond the diagnostic yield.

Respirology 2019 Mar 25. Epub 2019 Mar 25.

Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, USA.

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the commonly used technique for pathological confirmation of clinically suspected sarcoidosis, mostly owing to its consistently high success rate in the detection of granulomas. However, other possible advantages, which are less appreciated and often poorly studied, may also contribute to the wider use of EBUS-TBNA in the future. These advantages include refinement of differential diagnoses through the study of lymph node characteristics during B-mode examination; reduction of complications associated with bronchoscopy, as well as improved triage of the specimen for ancillary studies with the use of rapid on-site evaluation; optimization of the quality of the sample through the selection of a target area for biopsy with minimal vascularity and absence of calcifications by using the colour Doppler and the B-mode; and prediction of the presence of extensive lymph node fibrosis by using the strain elastography module. Read More

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http://dx.doi.org/10.1111/resp.13537DOI Listing
March 2019
2 Reads

Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients With Cardiac Sarcoidosis.

J Card Fail 2019 Apr 27;25(4):307-311. Epub 2019 Feb 27.

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California. Electronic address:

Background: Cardiac fluorodeoxyglucose positron-emission tomography (FDG-PET) has emerged as a standard imaging modality for the diagnosis of cardiac sarcoidosis (CS); however, there is a scarcity of data on the use of serial FDG-PET to guide immunosuppressive therapy. The aim of this work was to report our experience using serial FDG-PET for the diagnosis and management of patients with CS, focusing on its utility in ongoing immunosuppression management.

Methods And Results: We studied consecutive patients with CS managed at Stanford University from 2010 to 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10719164193020
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http://dx.doi.org/10.1016/j.cardfail.2019.02.018DOI Listing
April 2019
5 Reads

Influence of Mouth Pressure on Measurement of Diffusing Capacity in the Clinical Pulmonary Function Laboratory.

Respir Care 2019 Feb 26. Epub 2019 Feb 26.

Tufts Medical Center, Boston, Massachusetts.

Background: Current American Thoracic Society/European Respiratory Society guidelines recommend that patients hold their breath with minimum effort at total lung capacity during measurement of the single-breath diffusing capacity of the lung for carbon monoxide (D) to avoid excessively positive or negative mouth pressures. We asked to what extent do these pressures range during single-breath D testing and whether mouth pressures are associated with single-breath D.

Methods: We analyzed mouth pressures measured during clinical single-breath D testing in an academic pulmonary function laboratory over a 3-month period. Read More

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http://dx.doi.org/10.4187/respcare.06469DOI Listing
February 2019
1 Read

Research highlights from the 2018 ERS International Congress: interstitial lung diseases.

ERJ Open Res 2019 Feb 18;5(1). Epub 2019 Feb 18.

Dept of Diseases of the Thorax, Ospedale GB Morgagni, Forlì, Italy.

This article reviews a selection of the scientific presentations on interstitial lung disease (ILD)/diffuse parenchymal lung disease (DPLD) that were made at the 2018 European Respiratory Society (ERS) International Congress in Paris. A number of advances in the epidemiology, pathogenesis, diagnosis and treatment of these disorders were presented and discussed by clinicians and researchers. The research topics span over all four groups of ERS Assembly 12: Interstitial Lung Diseases (Group 12. Read More

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http://dx.doi.org/10.1183/23120541.00215-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378342PMC
February 2019
1 Read

Bidirectional association between tuberculosis and sarcoidosis.

Respirology 2019 May 5;24(5):467-474. Epub 2019 Feb 5.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background And Objective: Tuberculosis (TB) and sarcoidosis are both granulomatous diseases with potential interassociations. However, much uncertainty remains; thus, the present study aimed to clarify the association between these diseases.

Methods: We established two cohorts in this retrospective longitudinal cohort study using data obtained from the Taiwan National Health Insurance Database from 2000 to 2015. Read More

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http://dx.doi.org/10.1111/resp.13482DOI Listing
May 2019
9 Reads

Clinical significance of the determination of surfactant proteins A and D in assessing the activity of lung sarcoidosis.

Ter Arkh 2018 Apr;90(3):42-46

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To study the clinical significance of SP-A, SP-D in assessing the activity of idiopathic pulmonary fibrosis and sarcoidosis. We examined 81 patients with morphologically confirmed diagnoses of idiopathic pulmonary fibrosis (ILF) and sarcoidosis, a control group of 20 healthy individuals. The MSCT of the thoracic organs of the chest was performed, the diffusivity of the lungs was examined, oxygen saturation was determined. Read More

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http://dx.doi.org/10.26442/terarkh201890342-46DOI Listing
April 2018
1 Read

Multiple huge "cluster" and "galaxy" signs on chest radiography in a patient with pulmonary tuberculosis.

Respirol Case Rep 2019 Apr 25;7(3):e00398. Epub 2019 Jan 25.

Department of Respiratory Medicine Kyorin University School of Medicine Mitaka Japan.

A 62-year-old healthy man presented to our hospital due to a persistent fever of up to 38°C for one week. Thoracic computed tomography showed right pleural effusion with multiple large nodules up to 7 cm in diameter composed of numerous discrete small nodules like fireworks, the so-called "cluster" signs. Some of the large nodules had a hyper-dense portion centrally surrounded by partially discrete small nodules, not as densely assembled, suggestive of the "galaxy" sign. Read More

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http://dx.doi.org/10.1002/rcr2.398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346226PMC
April 2019
3 Reads

Thoracic Sarcoidosis: Imaging Patterns.

Semin Roentgenol 2019 Jan 27;54(1):59-65. Epub 2018 Dec 27.

Department of Radiology, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1053/j.ro.2018.12.008DOI Listing
January 2019
2 Reads

Hypertrophic cervical spine pachymeningitis due to sarcoidosis: a case report.

Hosp Pract (1995) 2019 Apr 6;47(2):99-103. Epub 2019 Feb 6.

d Pathology , Lehigh Valley Health Network , Allentown , PA , USA.

Hypertrophic pachymeningitis (HP) is a chronic, progressive diffuse inflammatory condition that leads to thickening of the dura mater and can be idiopathic or associated with sarcoidosis among other disorders. In this case report, we present a rare case of cervical spine HP in a 29-year-old woman in the post-partum period, who had a history of pituitary adenoma and juvenile rheumatoid arthritis. Magnetic resonance imaging (MRI) of the spine revealed a soft tissue mass and moderate cord compression. Read More

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https://www.tandfonline.com/doi/full/10.1080/21548331.2019.1
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http://dx.doi.org/10.1080/21548331.2019.1575645DOI Listing
April 2019
14 Reads

Sinonasal and Laryngeal Sarcoidosis-An Uncommon Presentation and Management Challenge.

Am J Med Sci 2019 Feb 22;357(2):93-102. Epub 2018 Nov 22.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

Sarcoidosis is a chronic inflammatory disease of uncertain etiology characterized by the formation of noncaseating granulomas. The thorax is involved in 95% of cases, but any organ can be involved. Sinonasal or laryngeal involvement is uncommon and can be difficult to diagnose. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029629183042
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http://dx.doi.org/10.1016/j.amjms.2018.11.007DOI Listing
February 2019
7 Reads

F-fluorodeoxyglucose positron emission tomography is useful for the diagnosis of intraocular sarcoidosis in patients with a normal CT scan.

Br J Ophthalmol 2019 Jan 18. Epub 2019 Jan 18.

Service de Médecine Interne, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France

Aim: To assess the usefulness of F-fluorodeoxyglucose positron emission tomography (F-FDG PET/CT) and the predictive factors for the diagnosis of sarcoidosis in patients with uveitis who have normal thoracic tomography.

Methods: We retrospectively reviewed 67 consecutive patients with uveitis of unknown aetiology or a suspected sarcoidosis. All patients with normal thoracic tomography underwent an F-FDG PET/CT, which was blindly reinterpreted. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313133DOI Listing
January 2019
6 Reads
2.976 Impact Factor

Case 2-2019: A 36-Year-Old Man with Rash, Abdominal Pain, and Lymphadenopathy.

N Engl J Med 2019 Jan;380(3):275-283

From the Departments of Medicine (S.T.C., E.T.R.), Dermatology (S.T.C.), Radiology (A.M.C.), and Pathology (R.K.F.), Massachusetts General Hospital, the Departments of Dermatology (S.T.C.), Medicine (E.T.R.), Radiology (A.M.C.), and Pathology (R.K.F.), Harvard Medical School, and the Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health (E.T.R.) - all in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1810390DOI Listing
January 2019
3 Reads

Bronchoscopic lung cryobiopsy: An Indian association for bronchology position statement.

Lung India 2019 Jan-Feb;36(1):48-59

Department of Pulmonary Medicine, Christian Medical College, Vellore, India.

Background: Bronchoscopic lung cryobiopsy (BLC) is a novel technique for obtaining lung tissue for the diagnosis of diffuse parenchymal lung diseases. The procedure is performed using several different variations of technique, resulting in an inconsistent diagnostic yield and a variable risk of complications. There is an unmet need for standardization of the technical aspects of BLC. Read More

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http://www.lungindia.com/text.asp?2019/36/1/48/249179
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http://dx.doi.org/10.4103/lungindia.lungindia_75_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330795PMC
January 2019
22 Reads

Pseudoachalasia as First Manifestation of a Malignancy.

Dig Dis 2019 Jan 2:1-8. Epub 2019 Jan 2.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria,

Pseudoachalasia is a condition in which symptoms, radiologic, endoscopic, and manometric findings mimick idiopathic achalasia. About 4% of patients with a typical constellation for idiopathic achalasia will turn out to have pseudoachalasia, posing a major diagnostic challenge. A large spectrum of underlying causes of pseudoachalasia has been described. Read More

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http://dx.doi.org/10.1159/000495758DOI Listing
January 2019
5 Reads

Multiorgan accelerated silicosis misdiagnosed as sarcoidosis in two workers exposed to quartz conglomerate dust.

Occup Environ Med 2019 Mar 4;76(3):178-180. Epub 2018 Dec 4.

Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.

Introduction: Clusters of silicosis cases have been reported in the fabrication of quartz conglomerate, a new high-silica-content artificial stone for kitchen and bathroom benchtops (countertops).

Aim: We describe two cases of accelerated-type silicosis with hepatic granulomas arising in workers exposed to artificial quartz conglomerates.

Methods: A confident diagnosis of multiorgan silicosis was based on high level of respirable silica in the workplace, typical radiological alterations in chest high-resolution CT, histological findings in the lung and liver, and detection of silica crystals in both tissues by phase-contrast polarising light microscopy and scanning electron microscopy and energy dispersive spectroscopy. Read More

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http://dx.doi.org/10.1136/oemed-2018-105462DOI Listing
March 2019
6 Reads

[Causes of mediastinal/hilar granulomatous lymphadenitis].

Tuberk Toraks 2018 Sep;66(3):212-216

Department of Pathology, Faculty of Medicine, Karadeniz Teknik University, Trabzon, Turkey.

Introduction: Granulomatous lung disease (GLD) is caused by a wide range of conditions and it is challenge for pulmonologist. A detailed history of exposures is fundamental in GDL and has been found pivotal to reach a precise diagnosis.

Materials And Methods: Between September 2014 and December 2016, the distribution of patients diagnosed with granulomatous lymphadenitis in the mediastinal/hilar lymph nodes by endobronchial ultrasound (EBUS) or mediastinoscopy was analyzed. Read More

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http://dx.doi.org/10.5578/tt.67018DOI Listing
September 2018
30 Reads

Detection of mitochondrial transfer RNA (mt-tRNA) gene mutations in patients with idiopathic pulmonary fibrosis and sarcoidosis.

Mitochondrion 2018 11 26;43:43-52. Epub 2018 Oct 26.

Department of Biochemistry & Biotechnology, University of Thessaly, BIOPOLIS, Larissa 41110, Greece.

Mitochondrial reactive oxygen species production may lead to tissue injury associated with two respiratory disorders of unknown origin which are shared by common tissue fibrosis, IPF and sarcoidosis. Sequence analysis of 22 mt-tRNA genes and parts of their flanking genes revealed 32 and 45 mutations in 38/40 IPF and 69/85 sarcoidosis patients respectively. 4 novel mutations were identified. Read More

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http://dx.doi.org/10.1016/j.mito.2018.10.004DOI Listing
November 2018
1 Read

The combination of EBUS-TBNA and the PAB antibody led to a successful treatment for lung cancer in a patient with asymptomatic sarcoidosis mimicking nodal metastasis.

Respir Med Case Rep 2018 18;25:296-299. Epub 2018 Oct 18.

Department of Pathology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan.

Correct staging of lung cancer is important for the selection of the best therapy, but discriminating between lymphadenopathy from lung cancer and from sarcoidosis by imaging examinations is difficult. Additionally, distinguishing lymphadenopathy of sarcoidosis from sarcoid reactions which are sometimes caused by lung cancer is difficult on imaging and pathological findings. A 73-year-old woman was diagnosed as lung cancer clinical T1bN3M0 stage ШB based on false-positive F-fluoro-2-deoxyglucose positron emission tomography uptake. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183030
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http://dx.doi.org/10.1016/j.rmcr.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198119PMC
October 2018
7 Reads

Utility of routine chest radiography in ocular tuberculosis and sarcoidosis.

Int J Tuberc Lung Dis 2018 Nov;22(11):1374-1377

Division of Pulmonology, Department of Medicine.

Background: Tuberculosis (TB) and sarcoidosis commonly present with pulmonary and ocular involvement. Routine chest radiography (CXR) is recommended in the workup for suspected intraocular TB (IOTB) or intraocular sarcoidosis (IOS); however, data on the utility of CXR in this setting are lacking.

Methods: A post-hoc analysis was performed of a prospectively collected data set comprising 104 patients with uveitis of unknown cause. Read More

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http://www.ingentaconnect.com/content/10.5588/ijtld.18.0013
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http://dx.doi.org/10.5588/ijtld.18.0013DOI Listing
November 2018
5 Reads

Hilar and mediastinal sarcoid-like reaction after the treatment of malignant tumors: imaging features and natural course on F-FDG-PET/CT.

Jpn J Radiol 2019 Jan 15;37(1):88-94. Epub 2018 Oct 15.

Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Purpose: This study aimed to assess the imaging features and natural course of hilar and mediastinal sarcoid-like reaction on F-fluorodeoxyglucose (FDG) PET/CT after the treatment of malignancies.

Methods: Sixteen patients with the appearance of sarcoid-like reaction seen on F-FDG-PET/CT after treatment were included. Hilar and mediastinal lymph node metastases were pathologically or clinically ruled out. Read More

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http://dx.doi.org/10.1007/s11604-018-0786-4DOI Listing
January 2019
4 Reads

Imaging findings in spinal sarcoidosis: a report of 18 cases and review of the current literature.

Neuroradiol J 2019 Feb 12;32(1):17-28. Epub 2018 Oct 12.

Neuroradiology Department, University of Iowa Hospitals and Clinics, USA.

Purpose: Spinal sarcoidosis, referring to involvement of the spine in sarcoidosis, is relatively rare and may mimic other neurological disease affecting the spine. The authors present a clinic radiological review of 18 spinal sarcoidosis patients who presented to a tertiary hospital, with emphasis on initial imaging and radiological response to treatment.

Materials And Methods: We retrospectively reviewed our departmental imaging archives over a 15-year period and found 49 cases of neurosarcoidosis out of which 18 patients had spinal magnetic resonance imaging. Read More

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http://journals.sagepub.com/doi/10.1177/1971400918806634
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http://dx.doi.org/10.1177/1971400918806634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327364PMC
February 2019
14 Reads

Cerebral granulomatosis as a manifestation of Crohn's disease.

BMC Neurol 2018 Oct 3;18(1):161. Epub 2018 Oct 3.

Department of Neurology and Neuroscience, Medical Center, University of Freiburg, Breisacher Straße 64, D-79106, Freiburg, Germany.

Background: Crohn's disease (CD) is associated with a variety of extra-intestinal manifestations. Most commonly these involve the eye, skin, joints, coagulation system and liver. Cerebral manifestations of CD have been reported to a far lesser extent. Read More

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http://dx.doi.org/10.1186/s12883-018-1163-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169107PMC
October 2018
18 Reads

Reprint of: The pathology of pulmonary sarcoidosis: update.

Semin Diagn Pathol 2018 Sep 24;35(5):324-333. Epub 2018 Sep 24.

Department of Lung Pathologist, KEck Medical Center of USC, Los Angeles, California. Electronic address:

Sarcoidosis is a multi-system disease of unknown etiology, usually affecting the respiratory tract and other organs, and is characterized by the formation of nonnecrotizing epithelioid granulomas. The diagnosis depends on a combination of a typical clinicoradiological presentation, the finding of nonnecrotizing epithelioid granulomas in a tissue biopsy, and exclusion of other possible diseases, especially those of infectious etiology. The granulomas contain epithelioid cells, giant cells, CD4+ T cells in their center, and CD8+ T lymphocytes and B lymphocytes at their periphery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570183006
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http://dx.doi.org/10.1053/j.semdp.2018.09.001DOI Listing
September 2018
9 Reads

Prevalence of Haemophilus influenzae with alteration of PBP 3 sequence over a 1-year period in a French hospital: focus on a clinical failure after ceftriaxone treatment.

Diagn Microbiol Infect Dis 2019 Feb 1;93(2):89-91. Epub 2018 Sep 1.

CHU Nantes, Service de Bactériologie-Hygiène, 9 quai Moncousu, Nantes Cedex 1, F-44093, France. Electronic address:

Among 547 Haemophilus influenzae isolates recovered in our center, 45 displayed a phenotype of loss of PBP 3 affinity (8.2%). Two isolates with 6 substitutions in PBP 3 showed decreased susceptibility to third-generation cephalosporins. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.08.013DOI Listing
February 2019
1 Read

Multi-drug-resistant tuberculosis with galaxy and cluster signs on high-resolution computed tomography.

Respirol Case Rep 2018 Nov 14;6(8):e00369. Epub 2018 Sep 14.

Department of Respiratory Medicine Fukujuji Hospital, Japan Anti-Tuberculosis Association Kiyose Japan.

The galaxy sign and cluster sign were first reported in pulmonary sarcoidosis. From those reports, these two signs became known as one of the characteristic computed tomography (CT) findings of sarcoidosis. We report a patient with pulmonary tuberculosis who had these two signs. Read More

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http://dx.doi.org/10.1002/rcr2.369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138543PMC
November 2018
12 Reads

Pulmonary Multiloculated 'Lotus Torus-like' Sarcoidosis Mimicking Lung Adenocarcinoma.

Intern Med 2019 Feb 12;58(3):419-422. Epub 2018 Sep 12.

Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Japan.

A 34-year-old Japanese woman exhibited a 35×25-mm solitary multiloculated mass shadow in the left lower lobe mimicking lung adenocarcinoma. On computed tomography, the mass resembled a lotus torus. A transbronchial lung biopsy and mediastinal lymph node biopsy led to the diagnosis of sarcoidosis. Read More

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http://dx.doi.org/10.2169/internalmedicine.1541-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395122PMC
February 2019
14 Reads

Relationship between CT activity score with lung function and the serum angiotensin converting enzyme in pulmonary sarcoidosis on chest HRCT.

Medicine (Baltimore) 2018 Sep;97(36):e12205

Department of Radiology, China-Japan Friendship Hospital, Beijing.

To address the reliability of CT activity score (CTAS) and investigate the relationships between CTAS, lung function changes after treatment and the serum angiotensin-converting enzyme (SACE) levels.Fifty-seven sarcoidosis patients underwent chest high-resolution CT (HRCT) and spirometry, as well as SACE examination, were retrospectively analyzed. Follow-up spirometry in each patient was obtained about 6 months after the initial spirometry. Read More

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http://dx.doi.org/10.1097/MD.0000000000012205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133449PMC
September 2018
2 Reads

Clinics in diagnostic imaging (189). Acute phase cardiac sarcoidosis (CS).

Singapore Med J 2018 08;59(8):407-412

Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore.

A 44-year-old man presented with breathlessness and episodes of palpitations for the last one year. The imaging diagnosis of cardiac sarcoidosis was made based on chest radiography and cardiac magnetic resonance (MR) imaging findings, and was further confirmed by biopsy. Cardiac sarcoidosis is an uncommon entity, yet is potentially fatal with nonspecific clinical manifestations, including sudden cardiac death. Read More

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http://www.smj.org.sg/article/clinics-diagnostic-imaging-189
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http://dx.doi.org/10.11622/smedj.2018095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109831PMC
August 2018
18 Reads

An Unusual Case of Dactylitis With Nail Unit Involvement: Answer.

Am J Dermatopathol 2018 Sep;40(9):701

Cabinet de dermatologie, Paris France.

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http://dx.doi.org/10.1097/DAD.0000000000000916DOI Listing
September 2018

Sarcoid-like reaction mimicking disease progression in an ALK-positive lung cancer patient receiving lorlatinib.

Invest New Drugs 2019 Apr 1;37(2):360-363. Epub 2018 Aug 1.

Medical Oncology Unit, University Hospital of Parma, Via Gramsci, 14, 43126, Parma, Italy.

The administration of target inhibitors is paramount to grant the longest survival in patients with ALK-positive non-small cell lung cancer (NSCLC). The eventual resistance to tyrosine kinase inhibitors (TKI) is monitored clinically and radiologically for prompt molecule shift to further generation TKI, if available. However, the early radiological detection of progression pattern (e. Read More

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http://dx.doi.org/10.1007/s10637-018-0652-3DOI Listing
April 2019
11 Reads
2.920 Impact Factor

Thoracic sarcoidosis versus tuberculosis: Need for a multi-disciplinary approach.

Indian J Radiol Imaging 2018 Apr-Jun;28(2):267-268

Department of Medicine, AIIMS, New Delhi, India E-mail:

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http://dx.doi.org/10.4103/ijri.IJRI_61_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038207PMC
July 2018
2 Reads

Atypical CT findings of pulmonary sarcoidosis: A case report.

Medicine (Baltimore) 2018 Jul;97(29):e11456

Department of Rheumatology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea.

Rationale: Pulmonary involvement occurs in about 90% of patients with sarcoidosis. However, delayed diagnosis sometimes occurs due to atypical thoracic imaging findings.

Patient Concerns: A 52-year-old woman presented with recurrent uveitis and fever of unknown origin. Read More

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http://dx.doi.org/10.1097/MD.0000000000011456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086523PMC
July 2018
18 Reads

[What contribution for mediastinoscopy in non-tumor specific mediastinal lesions?]

Rev Pneumol Clin 2018 Sep 17;74(4):242-247. Epub 2018 Jul 17.

Service de chirurgie thoracique, CHU Hassan II, BP. 1893, km 2200, route de Sidi Harazem, Fès 3000, Maroc; Faculté de médecine et de pharmacie, université Sidi Mohamed Ben Abdellah, Fès, Maroc.

Introduction: The aim of our study was to assess the interest of cervical mediastinoscopy in the management of benign mediastinal lymphadenopathy.

Method: We performed a single-center retrospective descriptive study over a period of 5 years (2013-2017) in the department of thoracic surgery of university hospital Hassan II of Fez.

Results: During this period, a total of 137 cervical mediastinoscopies were performed among which 68 for a benign disease. Read More

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http://dx.doi.org/10.1016/j.pneumo.2018.05.003DOI Listing
September 2018
2 Reads

Sarcoidosis: is cryobiopsy not cool enough? - Authors' reply.

Lancet Respir Med 2018 09 11;6(9):e45. Epub 2018 Jul 11.

Royal Brompton and Harefield National Health Service Foundation Trust, Interstitial Lung Disease Unit, London, UK.

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http://dx.doi.org/10.1016/S2213-2600(18)30217-0DOI Listing
September 2018
9 Reads

Sarcoidosis from Head to Toe: What the Radiologist Needs to Know.

Radiographics 2018 Jul-Aug;38(4):1180-1200

From the Department of Radiology, University of Texas MD Anderson Cancer Center, Pickens Academic Tower, 1400 Pressler St, Unit 1473, Houston, TX 77030-4009 (D.G.); Department of Radiology, Mayo Clinic Arizona, Phoenix/Scottsdale, Ariz (C.O.M.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (M.G.L., P.J.P.); Department of Radiology, Indiana University School of Medicine, Indianapolis, Ind (K.S.); and Mallinckrodt Institute of Radiology, Section of Abdominal Imaging, Washington University School of Medicine, St Louis, Mo (S.B.).

Sarcoidosis is a multisystem granulomatous disorder characterized by development of noncaseating granulomas in various organs. Although the etiology of this condition is unclear, environmental and genetic factors may be substantial in its pathogenesis. Clinical features are often nonspecific, and imaging is essential to diagnosis. Read More

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http://dx.doi.org/10.1148/rg.2018170157DOI Listing
October 2018
3 Reads

Case Report: Case report on multiple extradural thoracic lesions with myelopathy as the clinical presentation in a systemic sarcoidosis- another tale of a lurking entity.

Authors:
Sunil Munakomi

F1000Res 2018 3;7. Epub 2018 Jan 3.

Department of Neurosurgery, Nobel Teaching Hospital, Biratnagar, 0977, Nepal.

Herein, we report a rare case study of a sarcoidosis presenting with the features of compressive myelopathy. There were multiple extra-dural lesions in the thoracic region. Computerized Tomography (CT) of the chest revealed fibrotic changes with a pleural based nodular lesion in the right lung. Read More

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http://dx.doi.org/10.12688/f1000research.13553.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020724PMC
January 2018
6 Reads

Thoracic and cutaneous sarcoid-like reaction associated with anti-PD-1 therapy: longitudinal monitoring of PD-1 and PD-L1 expression after stopping treatment.

J Immunother Cancer 2018 Jun 13;6(1):52. Epub 2018 Jun 13.

Service de Pneumologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49000, Angers, France.

Background: Immune checkpoint inhibitors (ICI) target T cell inhibitory pathways that are responsible for cancer tolerance by down-modulating immune functions. ICI have revolutionized patients care with lung cancer. Nevertheless, restoring endogenous antitumor T-cell responses can induce immune related adverse events, such as sarcoidosis. Read More

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http://dx.doi.org/10.1186/s40425-018-0372-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001149PMC
June 2018
13 Reads

The Curious Omission of Treatment as a Predictor of Pulmonary Sarcoidosis Mortality.

Authors:
Jerome M Reich

Chest 2018 Jun;153(6):1507

Thoracic Oncology Program, Earle A Chiles Research Institute, Portland, OR. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2018.02.034DOI Listing
June 2018
6 Reads

Restrictive lung defects: parenchymal, chest wall and neuromuscular.

Thorax 2018 10 7;73(10):989-991. Epub 2018 Jun 7.

Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.

Sarcoidosis is a multisystem condition which may affect a number of organs and, within the cardiopulmonary system, most commonly manifests as parenchymal, airway-centred, nodal, vascular or cardiac disease. Pleural involvement is rare, but well described, and often presents as pleural effusions or pleural thickening. Here, we present the first case of active sarcoidosis manifesting as bilateral pleural calcification. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-211895DOI Listing
October 2018
5 Reads

Active cardiac sarcoidosis on standard chest computed tomography.

Eur Heart J Cardiovasc Imaging 2018 09;19(9):1025

King's College London & Guy's and St Thomas' PET Centre, Westminster Bridge road, London SE1 7EH, UK.

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http://dx.doi.org/10.1093/ehjci/jey075DOI Listing
September 2018
2 Reads

Gallium-68 DOTA-NOC PET/CT as an alternate predictor of disease activity in sarcoidosis.

Nucl Med Commun 2018 Aug;39(8):768-778

Nuclear Medicine.

Introduction: We evaluated the role of gallium-68-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-Nal3-octreotide (Ga-DOTA-NOC) PET/CT in assessing sarcoidosis disease activity.

Patients And Methods: Patients diagnosed with sarcoidosis underwent Ga-DOTA-NOC-PET/CT. The maximum standardized uptake value (SUVmax) at the pathological site and in the descending thoracic aorta (reference standard, SUVmed) were assessed. Read More

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http://Insights.ovid.com/crossref?an=00006231-900000000-9855
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http://dx.doi.org/10.1097/MNM.0000000000000869DOI Listing
August 2018
21 Reads

Endobronchial Ultrasound-guided Transbronchial Needle Aspiration With a 19-G Needle Device.

J Bronchology Interv Pulmonol 2018 Jul;25(3):218-223

Royal Brompton & Harefield NHS Foundation Trust.

Background: Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration is a well-established first-line minimally invasive modality for mediastinal lymph node sampling. Although results are excellent overall, the technique underperforms in certain situations. We aimed to describe our results using a new 19-G EBUS-guided transbronchial needle aspiration device to determine safety and feasibility of this approach. Read More

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http://dx.doi.org/10.1097/LBR.0000000000000500DOI Listing
July 2018
5 Reads

[Gastric sarcoidosis revealed by thoracic sarcoidosis].

Rev Pneumol Clin 2018 Sep 7;74(4):260-263. Epub 2018 May 7.

Service de pneumologie, hôpital 20-août, 6, rue Lahssen-Elaarjoun, 20250 Casablanca, Maroc.

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http://dx.doi.org/10.1016/j.pneumo.2018.03.003DOI Listing
September 2018
1 Read

Endocan Levels and Endothelial Dysfunction in Patients With Sarcoidosis.

Angiology 2018 Nov 10;69(10):878-883. Epub 2018 May 10.

1 Department of Cardiology, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.

A systemic inflammatory reaction is a common feature of both sarcoidosis and atherosclerosis. Endothelial-cell specific molecule 1 (endocan) is a marker of vascular pathology which also shows a correlation with inflammation, endothelial dysfunction, and atherosclerosis. The objective of this study was to evaluate the vascular involvement in sarcoidosis using serum endocan levels and brachial artery flow-mediated dilation (FMD), a marker of endothelial dysfunction. Read More

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http://dx.doi.org/10.1177/0003319718775283DOI Listing
November 2018
15 Reads
1 Citation
2.370 Impact Factor