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    Prevalence of immune-related systemic adverse events in patients treated with anti-Programmed cell Death 1/anti-Programmed cell Death-Ligand 1 agents: A single-centre pharmacovigilance database analysis.
    Eur J Cancer 2017 Jun 21;82:34-44. Epub 2017 Jun 21.
    Assistance Publique - Hôpitaux de Paris, Hôpital Bicêtre, Service de Médecine Interne et Immunologie Clinique, F-94275 Le Kremlin-Bicêtre, France; INSERM, U1184, Immunology of Viral Infections and Autoimmune Diseases, F-94276 Le Kremlin-Bicêtre, France; Université Paris Sud, UMR 1184, F-94276 Le Kremlin-Bicêtre, France; CEA, DSV/iMETI, IDMIT, F-92265 Fontenay-aux-Roses, France. Electronic address:
    Aim: The growing use of immune checkpoint inhibitors (ICIs) is associated with the occurrence of immune-related adverse events (irAEs). Few data are published on systemic, immunohaematological and rheumatic irAEs. In a pharmacovigilance database analysis, we screened for these irAEs and calculated their prevalence. Read More

    Ann Endocrinol (Paris) 2016 Oct;77 Suppl 1:S11-S18
    Fédération d'Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, 59 Boulevard Pinel, 69677 Bron, France; Université Lyon 1, 43 Boulevard du 11 novembre 1918, 69100 Villeurbanne, France.
    Diabetes insipidus is a syndrome that associates both hypotonic polyuria and polydipsia, due to insufficient or ineffective arginine vasopressin (AVP) synthesis, or to AVP resistance. The diagnosis between central/renal origin, or an abnormal thirst regulation (primary polydipsia) is required to organize an adapted management. Because water deprivation tests are not reliable, it's often based on medical history, response to treatment and MRI. Read More

    Anti-TNFα Therapy in Inflammatory Lung Diseases bn.
    Pharmacol Ther 2017 Jun 19. Epub 2017 Jun 19.
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA. Electronic address:
    Increased levels of tumor necrosis factor (TNF) α have been linked to a number of pulmonary inflammatory diseases including asthma, chronic obstructive pulmonary disease (COPD), acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), sarcoidosis, and interstitial pulmonary fibrosis (IPF). TNFα plays multiple roles in disease pathology by inducing an accumulation of inflammatory cells, stimulating the generation of inflammatory mediators, and causing oxidative and nitrosative stress, airway hyperresponsiveness and tissue remodeling. TNF-targeting biologics, therefore, present a potentially highly efficacious treatment option. Read More

    Use of systemic glucocorticoids and the risk of major osteoporotic fractures in patients with sarcoidosis.
    Osteoporos Int 2017 Jun 21. Epub 2017 Jun 21.
    Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
    This study revealed the risk of major osteoporotic fracture in patients with sarcoidosis exposed to glucocorticoids. Current use of glucocorticoids was associated with a risk of fracture, with no difference between patients with and without sarcoidosis. Sarcoidosis per se was not associated with an increased fracture risk. Read More

    Adalimumab-Responsive Refractory Sarcoidosis Following Multiple Eyebrow Tattoos: A Case Report.
    Tanaffos 2017 ;16(1):80-83
    Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran Iran.
    Sarcoidosis is a granulomatous disease that can involve multiple organs including the lungs, eyes, nerves, and skin. Cosmetic tattooing can be a predisposing factor for sarcoidosis, and its incidence is likely to increase along with its popularity. A 47-year-old woman with symptoms of fever and polyarthritis along with erythema nodosum lesions on the legs, swollen eyebrows, and a history of multiple eyebrow tattooing was referred to our center. Read More

    Mycobacterium chimaera Infection After Cardiac Surgery: First Canadian Outbreak.
    Ann Thorac Surg 2017 Jul;104(1):e43-e45
    Department of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Montreal, Québec, Canada. Electronic address:
    Recently reported in Europe and United States, disseminated Mycobacterium chimaera infection is a novel clinical entity linked to point contamination of Stockert 3T heater-cooler units used for cardiopulmonary bypass. We present here the first two cases in Canada. Both patients presented with nonspecific extracardiac symptoms 1 year after undergoing minimally invasive mitral surgical repair. Read More

    Nodular Cutaneous Amyloidoma of the Extremity Secondary to Chronic Granulomatous Inflammation in Setting of Sarcoidosis.
    J Cutan Pathol 2017 Jun 20. Epub 2017 Jun 20.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine.
    Soft tissue amyloidoma is a rare condition that presents primarily in the abdomen and/or mediastinum and more uncommonly on the extremities(1) . Soft tissue amyloidomas on the extremities have been associated with chronic inflammation, particularly when accompanied by AA-type amyloid deposition as seen in local trauma, surgery, hypertension, and diabetes(2) . To our knowledge, this is the first reported case of nodular cutaneous amyloidoma in the setting of systemic and cutaneous sarcoidosis. Read More

    Multiorgan Involvement of Chemotherapy-Induced Sarcoidosis Mimicking Progression of Lymphoma on FDG PET/CT.
    Clin Nucl Med 2017 Jun 19. Epub 2017 Jun 19.
    From the Department of Radiology, University of Illinois Hospital & Health Sciences System, Chicago, IL.
    A 35-year-old woman with biopsy-proven recurrent Hodgkin lymphoma in the neck lymph nodes received salvage chemotherapy of brentuximab/insulin growth factor-methotrexate. Although the patient continued doing well clinically with no constitutional symptoms or significant laboratory abnormalities following the second recurrence, subsequent FDG PET CT examinations over the next 2 years revealed multiple new FDG-avid foci including lymph nodes above/below the diaphragm, liver, spleen, lungs, and bone. An alternate diagnosis of chemotherapy-induced sarcoidosis was suggested and confirmed on both bone marrow and right inguinal node biopsy. Read More

    Bilaterally Diffuse Lacrimal Gland Involvement: Initial Presentation of Systemic Sarcoidosis.
    Turk J Ophthalmol 2017 Jun 1;47(3):165-168. Epub 2017 Jun 1.
    Ankara University Faculty of Medicine, Department of Pathology, Ankara, Turkey.
    Orbital involvement in systemic sarcoidosis is a rare condition. We report a case of orbital sarcoidosis with bilaterally huge lacrimal gland involvement as the initial manifestation of systemic sarcoidosis. A 20-year-old woman admitted the ophthalmology department with progressive bilateral upper eyelid swelling for 6 months. Read More

    Analysis of sarcoidosis in the Oporto region (Portugal).
    Rev Port Pneumol (2006) 2017 Jun 15. Epub 2017 Jun 15.
    Pneumology Department and Diffuse Lung Disease Study Group, Centro Hospitalar de São João, Porto, Portugal; Faculty of Medicine of Porto University, Porto, Portugal.
    Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Epidemiological studies of different populations are essential because clinical presentation, organ involvement, disease severity, and prognosis vary significantly according to region and population. The aim of this study was to assess epidemiological and clinical characteristics, staging factors, and clinical course in patients with sarcoidosis from a tertiary hospital in Oporto, Portugal. Read More

    Hybrid Magnetic Resonance Imaging and Positron Emission Tomography With Fluorodeoxyglucose to Diagnose Active Cardiac Sarcoidosis.
    JACC Cardiovasc Imaging 2017 Jun 9. Epub 2017 Jun 9.
    Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:
    Objectives: The purpose of this study was to explore the diagnostic usefulness of hybrid cardiac magnetic resonance (CMR) and positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) for active cardiac sarcoidosis.

    Background: Active cardiac sarcoidosis (aCS) is underdiagnosed and has a high mortality.

    Methods: Patients with clinical suspicion of aCS underwent hybrid CMR/PET with late gadolinium enhancement (LGE) and FDG to assess the pattern of injury and disease activity, respectively. Read More

    Acute tubulointerstitial nephritis in an HLA-B27-positive patient with axial spondyloarthritis being treated with adalimumab.
    Reumatol Clin 2017 Jun 14. Epub 2017 Jun 14.
    Servicio de Anatomía Patológica, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
    Antagonists of tumor necrosis factor-alpha (ATNF) are used for the treatment of multiple diseases such as psoriatic arthritis, Crohn's disease, ankylosing spondylitis and juvenile idiopathic arthritis, usually, when they are refractory to first-line treatment(1). The use of ATNF has been associated with the induction of autoimmune diseases such as systemic lupus erythematosus-like disease, vasculitis, sarcoidosis-like diseases and, recently, acute granulomatous tubulointerstitial nephritis. We report a case of acute nongranulomatous tubulointerstitial nephritis in an HLA-B27-positive patient with axial spondyloarthritis and Crohn's disease being treated with adalimumab. Read More

    Post-9/11 sarcoidosis in WTC-exposed firefighters and emergency medical service workers.
    Respir Med 2017 Jun 7. Epub 2017 Jun 7.
    Fire Department of the City of New York, Bureau of Health Services, 9 Metrotech Center, Brooklyn, NY, USA.
    Introduction: The World Trade Center (WTC) disaster released a huge quantity and variety of toxicants into the environment. To-date, studies from each of the three major cohorts of WTC-exposed workers have suggested "greater than expected" numbers of post-9/11 cases in some workers. We undertook this study to estimate the incidence of post-9/11 sarcoidosis in ∼13,000 male firefighters and EMS workers enrolled in The Fire Department of the City of New York (FDNY) WTC Health Program; to compare FDNY incidence to rates from unexposed, demographically similar men in the Rochester Epidemiology Project (REP); and, to examine rates by level of WTC exposure. Read More

    Ocular sarcoidosis: new diagnostic modalities and treatment.
    Curr Opin Pulm Med 2017 Jun 15. Epub 2017 Jun 15.
    aDepartment of Ophthalmology, Gangneung Asan Hospital, Ulsan University, South Korea bCasey Eye Institute cDivision of Arthritis and Rheumatic Diseases, Oregon Health & Science University dLegacy Devers Eye Institute, Portland, Oregon, USA.
    Purpose Of Review: Ocular involvement in sarcoidosis is present in up to 80% of patients and is frequently manifested before diagnosis of the underlying systemic disease. Considering the therapeutic consequences, early diagnosis of the underlying disease is advantageous in patients presenting with ocular inflammation. There are several ocular findings suggestive of underlying sarcoidosis, such as granulomatous keratic precipitates, iris nodules, cells in the vitreous humor known as snowballs and snowbanks, and retinal periphlebitis. Read More

    Chronic pulmonary aspergillosis complicating sarcoidosis.
    Eur Respir J 2017 Jun 15;49(6). Epub 2017 Jun 15.
    Paris 13 University, EA2363, Sorbonne Paris Cité, Bobigny, France.
    Chronic pulmonary aspergillosis (CPA) complicating sarcoidosis (SA) is associated with high mortality, and there is a lack of clarity regarding the relative contributions of SA or CPA.This was a retrospective single-centre study on CPA-SA.In total, 65 patients (44 men), aged 41. Read More

    Chronic respiratory disease in the regional and remote population of the Northern Territory Top End: A perspective from the specialist respiratory outreach service.
    Aust J Rural Health 2017 Jun 15. Epub 2017 Jun 15.
    Royal Darwin Hospital, Darwin, Northern Territory, Australia.
    Objective: To study the demographic, rates and types of chronic respiratory conditions in Indigenous and non-Indigenous patients in regional and remote communities of Northern Territory Top End, who were referred to the specialist respiratory outreach service.

    Design: A retrospective, observational study over a 2 years period.

    Setting: Remote community health clinics within the Northern Territory Top End visited by the specialist respiratory outreach team. Read More

    Sarcoidosis of the lacrimal gland as a first manifestation.
    Arch Soc Esp Oftalmol 2017 Jun 10. Epub 2017 Jun 10.
    Servicio de Patología, Hospital Central Sur de Alta Especialidad-PEMEX, Ciudad de México, México.
    Objective/method: The first manifestation of sarcoidosis is usually at the pulmonary level. The case is described of a 40-year-old female patient, who presented with an increased volume of the lacrimal gland and mechanical ptosis of upper left eyelid as the first expression of this disease.

    Result/conclusion: The diagnosis of systemic sarcoidosis with primary presentation of the lacrimal gland was made after performing several immunological studies with negative results, imaging studies, and taking of glandular and lymph node biopsies. Read More

    Fatigue and Excessive Daytime Sleepiness in Sarcoidosis: Prevalence, Predictors, and Relationships between the Two Symptoms.
    Respiration 2017 Jun 14. Epub 2017 Jun 14.
    Department of Respiratory Medicine, University of Leipzig, Leipzig, Germany.
    Background: Fatigue is common among patients with sarcoidosis. The etiology of this problem is unknown and multifactorial. Fatigue can be confounded with excessive daytime sleepiness (EDS). Read More

    [Granulomatous reaction pattern of the skin : Interstitial granulomatous dermatitis - lymphoma - vasculitis].
    Hautarzt 2017 Jun 12. Epub 2017 Jun 12.
    Konsultations- und Referenzzentrum für Vaskulitis-Diagnostik, MVZ am Marienkrankenhaus gGmbH, Hamburg, Deutschland.
    A particular diagnostic situation in the classification of a granulomatous dermatitis results when no circumscribed granulomas but instead a diffuse interstitial histiocytic inflammatory infiltrate, a granulomatous vasculitis or a neoplastic lymphocytic infiltrate is found. Interstitial granulomatous dermatitis was originally described in patients with arthritis. Later, it was recognized that there are also associations with other usually immunological diseases. Read More

    Characteristics and Long-Term Outcome of Neurosarcoidosis: A Population-Based Study from 1976-2013.
    Neuroepidemiology 2017 Jun 10;48(3-4):87-94. Epub 2017 Jun 10.
    Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background/aims: Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting.

    Methods: Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sarcoidosis from Olmsted County, Minnesota, United States from 1976 to 2013 using individual medical record review. Read More

    A Diagnostic Approach to Recurrent Orofacial Swelling: A Retrospective Study of 104 Patients.
    Mayo Clin Proc 2017 Jun 7. Epub 2017 Jun 7.
    Department of Dermatology, Mayo Clinic, Scottsdale, AZ.
    Objective: To identify patients evaluated in an outpatient setting at our institution with a presentation of recurrent orofacial swelling and to review the spectrum of causes to outline a diagnostic approach.

    Patients And Methods: A retrospective study of 104 patients with more than 1 episode of orofacial swelling lasting for more than 5 days identified through a keyword search of the electronic health record from January 2, 2000, through July 5, 2011.

    Results: Patients were categorized according to final cause of orofacial swelling: idiopathic orofacial granulomatosis, solid facial edema due to rosacea and acne vulgaris, Crohn disease, contact dermatitis, sarcoidosis, exfoliative cheilitis, lichen planus, actinic cheilitis, cheilitis glandularis, lymphedema, miscellaneous, and multifactorial. Read More

    A 58-Year-Old Man With Fatigue, Weight Loss, and Diffuse Miliary Pulmonary Opacities.
    Chest 2017 Jun;151(6):e131-e134
    Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ. Electronic address:
    Case Presentaion: A 58-year-old man presented with a 6-month history of profound fatigue and a weight loss of 35 to 40 pounds. He reported occasional night sweats and mildly painful knees and elbows without swelling or redness. He denied respiratory symptoms, rashes, or fevers. Read More

    Cutaneous sarcoidosis.
    Curr Opin Pulm Med 2017 Jun 8. Epub 2017 Jun 8.
    aDepartment of Dermatology bDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    Purpose Of Review: Cutaneous sarcoidosis occurs in up to 30% of patients with sarcoidosis and skin findings are often the initial presenting symptom. Cutaneous sarcoidosis is a rare skin disease and many aspects of the disease presentation and treatment are not well understood. This review will highlight developments in the epidemiology, clinical presentation, diagnosis and treatment of cutaneous sarcoidosis over the past several years. Read More

    Many faces of neurosarcoidosis: from chronic meningitis to myelopathy.
    Curr Opin Pulm Med 2017 Jun 8. Epub 2017 Jun 8.
    aDepartment of Neurology, Academic Medical Centre, Centre of Infection and Immunity Amsterdam (CINIMA), Amsterdam bDepartment of Pulmonology, ILD Centre of Excellence, St. Antonius Hospital, Nieuwegein cDivision of Heart & Lungs, Department of Pulmonology, University Medical Centre, Utrecht dDepartment of Pharmacology and Toxicology, FHML, University Maastricht, Maastricht, The Netherlands.
    Purpose Of Review: Neurosarcoidosis occurs in 5% of patients with sarcoidosis and can be difficult to diagnose. In this review we discuss the most recent advances in our understanding of the disease, describing clinical characteristics, diagnostic process, treatment, and prognosis.

    Recent Findings: Clinical presentation is heterogeneous with most patients presenting with cranial nerve palsy, headache, or sensory abnormalities. Read More

    Current concepts regarding calcium metabolism and bone health in sarcoidosis.
    Curr Opin Pulm Med 2017 Jun 8. Epub 2017 Jun 8.
    aDepartment of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, ISA bDepartment of Pulmonary Medicine, Corfu General Hospital, Corfu c2nd Pulmonary Department, ATTIKON University Hospital, Athens, Greece.
    Purpose Of Review: Vitamin D supplementation is widespread used in the general population. In sarcoidosis, up to 50% of patients, especially postmenopausal women and those taking corticosteroids, show evidence of increased bone fragility. The purpose of this review is to provide an evidence-based rationale on how to treat sarcoidosis patients with bone health issues. Read More

    A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent TB Infection.
    Am J Respir Cell Mol Biol 2017 Jun 9. Epub 2017 Jun 9.
    The Ohio State University Wexner Medical Center, Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, Columbus, Ohio, United States ;
    Many aspects of pathogenic granuloma formation are poorly understood requiring new relevant laboratory models that represent the complexity (genetics and diversity) of human disease. To address this need, we developed an in vitro model of granuloma formation using human peripheral blood mononuclear cells (PBMCs) derived from patients with active sarcoidosis, latent tuberculosis (TB) infection (LTBI), or normal healthy controls. PBMCs were incubated for 7 days with uncoated polystyrene beads or beads coated with purified protein derivative (PPD) or human serum albumin (HSA). Read More

    Isolated gastric sarcoidosis: a rare entity.
    BMJ Case Rep 2017 Jun 8;2017. Epub 2017 Jun 8.
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
    We present a case of isolated granulomatous gastritis in a 21-year-old woman. Initial symptoms included nausea, vomiting and inability to tolerate oral intake. An upper oesophagogastroduodenoscopy revealed nodular and thickened mucosa with histological findings of granulomatous gastritis. Read More

    [Facial manifestations of granulomatous diseases].
    Hautarzt 2017 Jun 7. Epub 2017 Jun 7.
    Hautklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz KöR, Langenbeckstr. 1, 55131, Mainz, Deutschland.
    Clinical manifestations of granulomatous diseases are a recurring challenge in everyday dermatological practice. Clinical presentation and histological patterns are variable, depending on the particular disease. Knowledge about the differential diagnosis of granulomatous changes in the face is of decisive importance for making a rational diagnosis and therapy considering the patient's well-being. Read More

    Ocular sarcoidosis masked by positive IgM for toxoplasmosis.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):125-127
    Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    We report a case of ocular sarcoidosis with positive immunoglobulin (Ig) M and IgG serology for toxoplasmosis. The patient was a young female with red painful eyes, bilateral eyelid edema, and panuveitis with periphlebitis. In laboratory testing, she was IgM and IgG positive for toxoplasmosis and anergic in the tuberculin test. Read More

    Transcriptome profiles in sarcoidosis and their potential role in disease prediction.
    Curr Opin Pulm Med 2017 Jun 5. Epub 2017 Jun 5.
    aSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut, USA bClinic for Pneumology, Hannover Medical School cFraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover and German Center for Lung Research, DZL BREATH, Hannover, Germany *Jonas C. Schupp and Milica Vukmirovic contributed equally to this work.
    Purpose Of Review: Sarcoidosis is a systemic disease defined by the presence of nonnecrotizing granuloma in the absence of any known cause. Although clinically, the heterogeneity of sarcoidosis is well characterized, the transcriptome of the sarcoidosis and underlying molecular mechanisms are not. The signal of all transcripts, small and long noncoding RNAs, can be detected using microarrays or RNA-Sequencing. Read More

    Bronchoscopic modalities to diagnose sarcoidosis.
    Curr Opin Pulm Med 2017 Jun 5. Epub 2017 Jun 5.
    Interventional Pulmonology, Division of Pulmonary and Critical Care Medicine, University of Cincinnati, Ohio, USA.
    Purpose Of Review: Several studies have investigated different bronchoscopic techniques to obtain tissue diagnosis in patients with suspected sarcoidosis when the diagnosis cannot be based on clinicoradiographic findings alone. In this review, we will describe the most recent and relevant evidence from different bronchoscopic modalities to diagnose sarcoidosis.

    Recent Findings: Despite multiple available bronchoscopic modalities to procure tissue samples to diagnose sarcoidosis, the vast majority of evidence favors endobronchial ultrasound transbronchial needle aspiration to diagnose Scadding stages 1 and 2 sarcoidosis. Read More

    Cytopathologic findings of cell block materials from the vitreous: Diagnostic distinction between intraocular lymphoma and non-lymphomatous diseases.
    Pathol Int 2017 Jun 7. Epub 2017 Jun 7.
    Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.
    Intraocular lymphoma is a rare neoplasm that occurs only in the eyes and/or central nervous system. Diagnosis of intraocular lymphoma is difficult because its clinical manifestations mimic chronic uveitis. Pathological examination of the vitreous is one of the main diagnostic tools for intraocular lymphoma, but this is challenging due to the sparse cellularity and specimen degeneration. Read More

    Inflammatory myofibroblastic tumor mimicking a relapse in a patient with Hodgkin's lymphoma: report of an unusual case and review of the literature.
    Clin Case Rep 2017 Jun 4;5(6):945-949. Epub 2017 May 4.
    Koç University School of MedicineDepartment of Internal MedicineDivision of HematologyIstanbulTurkey.
    New PET-positive lesions in previously treated patients with lymphomatous malignancies need further investigations. Relapse, sarcoidosis and secondary malignancies are the most important differential diagnosis. Inflammatory myofibroblastic tumors (IMT) is a rare complication after treatment of Hodgkin's disease and every PET-positive lesion should be biopsied to prevent unnecessary intervention. Read More

    Endocardial and epicardial focal activation pattern due to microreentry ventricular tachycardia in a patient with cardiac sarcoidosis.
    Clin Case Rep 2017 Jun 17;5(6):829-832. Epub 2017 Apr 17.
    Division of Arrhythmia and ElectrophysiologyDepartment of Cardiovascular MedicineNational Cerebral and Cardiovascular CenterSuitaJapan.
    Majority of ventricular tachycardias (VTs) are caused by scar-related macroreentry in patients with cardiac sarcoidosis. These VTs usually exhibit the reentry circuit on electroanatomic maps. We here describe a rare case of VT that exhibits a focal activation pattern on the electroanatomic map despite reentrant VT. Read More

    Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.
    J Allergy Clin Immunol 2017 Jun 3. Epub 2017 Jun 3.
    Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. Electronic address:
    Background: Blau syndrome, or early-onset sarcoidosis, is a juvenile-onset systemic granulomatosis associated with a mutation in nucleotide-binding oligomerization domain 2 (NOD2). The underlying mechanisms of Blau syndrome leading to autoinflammation are still unclear, and there is currently no effective specific treatment for Blau syndrome.

    Objectives: To elucidate the mechanisms of autoinflammation in patients with Blau syndrome, we sought to clarify the relation between disease-associated mutant NOD2 and the inflammatory response in human samples. Read More

    Dendritic Cell Trafficking and Function in Rare Lung Diseases.
    Am J Respir Cell Mol Biol 2017 Jun 6. Epub 2017 Jun 6.
    University of Cincinnati, Cincinnati, Ohio, United States ;
    Dendritic cells (DCs) are highly specialized immune cells that capture antigens and then migrate to lymphoid tissue and present antigen to T cells. This critical function of DCs is well defined and recent studies further demonstrate that DCs are also key regulators of several innate immune responses. Studies focused on the roles of DCs in the pathogenesis of common lung diseases such as asthma, infection and cancer have traditionally driven our mechanistic understanding of pulmonary DC biology. Read More

    (18)F-FDG-PET in Finnish patients with clinical suspicion of cardiac sarcoidosis: Female sex and history of atrioventricular block increase the prevalence of positive PET findings.
    J Nucl Cardiol 2017 Jun 5. Epub 2017 Jun 5.
    Department of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, 33520, Tampere, Finland.
    Introduction: Fluorodeoxyglucose positron emission tomography (FDG-PET) is a non-invasive imaging modality that has been shown to be a feasible method to demonstrate myocardial inflammation. The aim of this study was to identify the patients suspected of having cardiac sarcoidosis (CS), who are most likely to benefit from PET imaging.

    Materials And Methods: 137 patients suspected of having CS underwent a dedicated cardiac FDG-PET examination at Tampere University Hospital between August 2012 and September 2015. Read More

    Use of Topical Corticosteroids in Dermatology: An Evidence-based Approach.
    Indian J Dermatol 2017 May-Jun;62(3):237-250
    Department of Dermatology, KPC Medical College and Hospital, Kolkata, West Bengal, India.
    Topical corticosteroids (TCs) are the pillars of dermatotherapeutics. These drugs are the "magic molecules," provided they are used judiciously and appropriately, following a rational prescription. On exhaustive literature search in multiple databases, we found a significant evidence favoring the use of TCs in atopic eczema, localized vitiligo, psoriasis, chronic hand eczema, and localized bullous pemphigoid. Read More

    Living Kidney Donation From a Donor With Pulmonary Sarcoidosis: A Case Report and Review of the Literature.
    Transplant Proc 2017 Jun;49(5):1183-1186
    Department of Urology, Tokyo Metropolitan Health and Medical Treatment Corporation Okubo Hospital, Kabukicho, Shinjuku-ku, Tokyo, Japan.
    Background: Sarcoidosis is a chronic systemic disease that is characterized by the formation of noncaseating granuloma and whose etiology is unclear. It is unclear whether patients with sarcoidosis are suitable organ donors.

    Case: We treated a 56-year-old woman with pulmonary sarcoidosis who donated her kidney. Read More

    Benign Bone Conditions That May Be FDG-avid and Mimic Malignancy.
    Semin Nucl Med 2017 Jul 12;47(4):322-351. Epub 2017 Apr 12.
    Department of Radiology and Nuclear Medicine, Deventer Ziekenhuis, Deventer, The Netherlands.
    Positron emission tomography with the radiotracer (18)F-fluoro-2-deoxy-d-glucose (FDG) plays an important role in the evaluation of bone pathology. However, FDG is not a cancer-specific agent, and knowledge of the differential diagnosis of benign FDG-avid bone alterations that may resemble malignancy is important for correct patient management, including the avoidance of unnecessary additional invasive tests such as bone biopsy. This review summarizes and illustrates the spectrum of benign bone conditions that may be FDG-avid and mimic malignancy, including osteomyelitis, bone lesions due to benign systemic diseases (Brown tumor, Erdheim-Chester disease, Gaucher disease, gout and other types of arthritis, Langerhans cell histiocytosis, and sarcoidosis), benign primary bone lesions (bone cysts, chondroblastoma, chondromyxoid fibroma, desmoplastic fibroma, enchondroma, giant cell tumor and granuloma, hemangioma, nonossifying fibroma, and osteoid osteoma and osteoblastoma), and a group of miscellaneous benign bone conditions (post bone marrow biopsy or harvest status, bone marrow hyperplasia, fibrous dysplasia, fractures, osteonecrosis, Paget disease of bone, particle disease, and Schmorl nodes). Read More

    Coexisting Sickle Cell Anemia and Sarcoidosis: A Management Conundrum!
    Clin Med Insights Blood Disord 2017 28;10:1179545X16685314. Epub 2017 Feb 28.
    Howard County General Hospital, USA.
    Sickle cell disease and Sarcoidosis are conditions that are more common in the African American population. In this report we share an unfortunate patient who had hepatic sarcoidosis but could not receive steroids since that precipitated acute liver failure. We have discussed potential therapy options but we need more options that improve mortality. Read More

    RNA-sequencing Identifies Novel Pathways in Sarcoidosis Monocytes.
    Sci Rep 2017 Jun 2;7(1):2720. Epub 2017 Jun 2.
    Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, MI, 48201, USA.
    Sarcoidosis is a complex systemic granulomatous disorder of unknown etiology. Genome-wide association studies have not been able to explain a causative role for nucleotide variation in its pathogenesis. The goal of the present study was to identify the gene expression profile and the cellular pathways altered in sarcoidosis monocytes via RNA-sequencing. Read More

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