29,629 results match your criteria Sarcoidosis


Sarcoidosis occurring during BRAF/MEK inhibitors is associated with paradoxical ERK activation in Erdheim-Chester patients.

J Eur Acad Dermatol Venereol 2019 Apr 19. Epub 2019 Apr 19.

Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Service de Médecine Interne 2, Centre National de Référence Maladies Systémiques Rares, Lupus Systémique, Syndrome des Anticorps Antiphospholipides et Histiocytoses, Paris, 75013, France.

Almost 70% of patients with Erdheim-Chester disease (ECD), a rare non-Langerhans cell histiocytosis, harbor the somatic V600E mutation of the BRAF gene. BRAF and MEK inhibitors are dramatically efficacious for treating ECD, particularly in cases of life-threatening manifestations [1]. Sarcoidosis-like disorders have been described during treatments with targeted therapies for cancers [2]. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15636
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http://dx.doi.org/10.1111/jdv.15636DOI Listing
April 2019
1 Read

Moving Target - Shifting the Focus to Pulmonary Sarcoidosis as an Autoimmune Spectrum Disorder.

Eur Respir J 2019 Apr 18. Epub 2019 Apr 18.

Respiratory Medicine Unit, Department of Medicine, Solna and Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden.

Despite over a century of research, the causative agent(s) in sarcoidosis, a heterogeneous granulomatous disorder mainly affecting the lungs, remain elusive. Following identification of genetic factors underlying different clinical phenotypes, increased understanding of CD4 T-cell immunology, which is believed to be central to sarcoid pathogenesis, as well as the role of B-cells and other cells bridging innate and adaptive immunity, is now contributing to novel insights into the mechanistic pathways influencing disease resolution or chronicity. Hopefully, new perspectives and state-of-the-art technology may help to shed light on the still-elusive enigma of sarcoid aetiology. Read More

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http://dx.doi.org/10.1183/13993003.021532018DOI Listing

The role of mediastinoscopy in the diagnosis of thoracic disease: 107-case analysis.

Med Glas (Zenica) 2019 Aug 1;16(2). Epub 2019 Aug 1.

Department of Thoracic Surgery, School of Medicine, Canakkale Onsekiz Mart University, Turkey.

Aim To evaluate the efficacy, safety and feasibility of mediastinoscopy in 107 cases with mediastinal lesions that could not be diagnosed histopathologically with other methods. Methods A total of 107 cases (73 males, 34 females; mean age 57.4, range 30-88 years) with mediastinal lymphadenopathy, who underwent mediastinoscopy between 12 September 2012 and 29 November 2018 were examined retrospectively. Read More

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http://ljkzedo.ba/mgpdf/mg31/01_Kapicibasi_1001_A.pdf
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http://dx.doi.org/10.17392/1001-19DOI Listing
August 2019
1 Read

Autoimmune pulmonary alveolar proteinosis in a patient with sarcoidosis.

Clin Case Rep 2019 Apr 2;7(4):731-734. Epub 2019 Mar 2.

Second Division, Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan.

Steroids used to treat sarcoidosis may induce aPAP. The cooccurrence of sarcoidosis and autoimmune pulmonary alveolar proteinosis (aPAP) is rare. In this case, aPAP merged into sarcoidosis regardless of the disease state of sarcoidosis and improved naturally. Read More

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http://dx.doi.org/10.1002/ccr3.2068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452467PMC

A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia.

Clin Case Rep 2019 Apr 20;7(4):695-698. Epub 2019 Feb 20.

2nd Department of Dermatology and Venereology, General Hospital "Papageorgiou", Medical School Aristotle University of Thessaloniki Thessaloniki Greece.

Palisaded neutrophilic granulomatous dermatitis is a cutaneous marker of a systemic disease. Clinicians' goal should be directed toward determining an underlying condition. Even if the initial investigation is inconclusive, it may be necessary that some tests are repeated, since a serious underlying disease could be revealed in the course of time. Read More

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http://dx.doi.org/10.1002/ccr3.2072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452460PMC

Exercise-related sudden cardiac death of an American football player with arrhythmogenic right ventricular dysplasia/cardiomyopathy AND sarcoidosis.

Clin Case Rep 2019 Apr 19;7(4):686-688. Epub 2019 Feb 19.

Department of Electrophysiology, Heart Center University of Leipzig Leipzig Germany.

This case emphasizes the value of cardiac MRI and genetic testing in the early phase of ARVD/C. It also emphasizes the increased risk of SCD for patients with ARVD/C participating in competitive sports, even with immediate cardiopulmonary resuscitation. Read More

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http://dx.doi.org/10.1002/ccr3.2071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452462PMC

Obstructive sleep apnoea in patients with fibrotic diffuse parenchymal lung disease-characterization and treatment compliance assessment.

Can J Respir Ther 2018 1;54(2):35-40. Epub 2018 Aug 1.

Pulmonology Department, Centro Hospitalar São João, Oporto, Portugal.

Introduction: Recent studies have reported a high prevalence of obstructive sleep apnoea (OSA) among patients with diffuse parenchymal lung disease (DPLD), mainly idiopathic pulmonary fibrosis (IPF). Effective OSA treatment appears to have a positive impact on morbidity and mortality in these patients. However, poor compliance to positive airway pressure (PAP) treatment in fibrotic DPLD patients has been reported. Read More

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http://dx.doi.org/10.29390/cjrt-2018-005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422053PMC

Progressive Right Ventricular Aneurysm in a Patient with Systemic Sarcoidosis.

J Cardiovasc Imaging 2019 Apr;27(2):158-161

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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https://synapse.koreamed.org/DOIx.php?id=10.4250/jcvi.2019.2
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http://dx.doi.org/10.4250/jcvi.2019.27.e18DOI Listing
April 2019
1 Read

Role of EBUS-TBNA in the Diagnosis of Tuberculosis and Sarcoidosis.

J Cytol 2019 Apr-Jun;36(2):128-130

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) has diagnostic accuracy and negative predictive value for the diagnosis of mediastinal tubercular lymphadenitis, especially when culture and cytological diagnosis is combined with high clinical suspicion. Both sarcoidosis and tuberculosis (TB) demonstrate granulomatous inflammation on cytology. Diagnosis of sarcoidosis in regions with a high burden of TB is challenging. Read More

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http://www.jcytol.org/text.asp?2019/36/2/128/253727
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http://dx.doi.org/10.4103/JOC.JOC_150_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425784PMC
April 2019
1 Read

Characterization of Blau syndrome panuveitis with wide-field fluorescein angiography.

Am J Ophthalmol Case Rep 2019 Jun 29;14:92-94. Epub 2019 Mar 29.

Department of Ophthalmology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Purpose: To describe a case of Blau panuveitis, characterized on both portable and tabletop wide-field fluorescein angiography, which resolved on systemic immunosuppression.

Observations: A 5-year-old female presented with bilateral eye pain, redness, and decreased visual acuity due to panuveitis and had a history of arthritis, tenosynovitis, and dermatitis. Similar ocular and systemic findings in the patient's mother and maternal half-brother prompted genetic testing that confirmed the diagnosis of the rare Blau syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936183023
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http://dx.doi.org/10.1016/j.ajoc.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447728PMC
June 2019
1 Read

Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e533-e536. Epub 2019 Mar 28.

Department of Medicine, Sultan Qaboos University Hospital, Muscat, Oman.

The coexistence of cystic fibrosis (CF) and sarcoidosis is rare. We report a 22-year-old male cystic fibrosis patient who presented multiple times to the Sultan Qaboos University Hospital, Muscat, Oman, in 2013. He was diagnosed with non-parathyroid-related hypercalcaemia and anterior uveitis, while computed tomography revealed mediastinal and abdominal lymphadenopathy and mild hepatosplenomegaly. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443288PMC
November 2018

[Cutaneous Lesions of Sarcoidosis].

Authors:
Hiroyuki Okamoto

Brain Nerve 2019 Apr;71(4):345-349

Department of Dermatology, Kansai Medical University.

Cutaneous lesions of sarcoidosis show varied clinical features. They are categorized into specific types; skin sarcoid, scar infiltrations with granulomas and foreign bodies, and non-specific lesions like erythema nodosum. Identification of the cutaneous lesions is important for the diagnosis of sarcoidosis, because they are an easily accessible source of tissue for histologic examination. Read More

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http://dx.doi.org/10.11477/mf.1416201273DOI Listing

Correlation between the Diagnostic Yield from the Bronchoalveolar Lavage Fluid Analysis and Clinicoradiological Findings in Sarcoidosis.

Turk Thorac J 2019 Apr 9. Epub 2019 Apr 9.

Clinic of Pulmonology, University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey.

Objectives: The diagnosis of sarcoidosis is frequently challenging, requiring a search for less invasive, more reliable diagnostic methods. The bronchoalveolar lavage fluid (BALF) analysis has been used in the differential diagnosis of sarcoidosis for many years with a wide sensitivity and specificity rates. The objective of the study is to investigate whether diagnostic performance of the BALF analysis is altered by clinicoradiological findings of patients with sarcoidosis. Read More

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http://turkthoracj.org/eng/makale/1107/154/Full-Text
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http://dx.doi.org/10.5152/TurkThoracJ.2018.180140DOI Listing
April 2019
2 Reads

Comprehensive Evaluation of the Factors Affecting Plasma Circulating Cell-Free DNA Levels and Their Application in Diagnosing Nonsmall Cell Lung Cancer.

Genet Test Mol Biomarkers 2019 Apr;23(4):270-276

1 Department of Clinical Pharmacology Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China.

Aims: Circulating cell-free DNA (ccfDNA) is a valuable biomarker, but the ccfDNA levels are influenced by variations that occur during sample processing. The feasibility of using ccfDNA as a diagnostic biomarker requires further examination.

Materials And Methods: We established a real-time PCR assay with an external standard to comprehensively evaluate the factors affecting ccfDNA levels, including the extraction kit used, freeze-thaw stability, and stability of delayed extraction. Read More

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http://dx.doi.org/10.1089/gtmb.2018.0106DOI Listing

[Sarcoidosis].

Rev Prat 2019 Jan;69(1):83-95

AP-HP, service de pneumologie, hôpital Avicenne, Bobigny, France EA2363, « Hypoxie et Poumon », Paris-13 SMBH, Bobigny, France.

Sarcoidosis. Sarcoidosis is a rare, systemic granulomatosis disease of unknown cause. In almost all cases sarcoidosis affects the lung and the lymphatic system. Read More

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January 2019
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A Trained Pulmonologist Can Reliably Assess Endosonography-Derived Lymph Node Samples during Rapid On-Site Evaluation.

Respiration 2019 Apr 12:1-9. Epub 2019 Apr 12.

Interventional Pulmonology Unit, Policlinico Sant'Orsola-Malpighi and Ospedale Maggiore, Bologna, Italy,

Background: The widespread use of rapid on-site evaluation is hampered by constraints related to time and resources, inadequate reimbursement, and evidence from randomized trials that show a lack of increase in diagnostic yield and specimen adequacy associated with its usage.

Objective: We aimed to verify whether a pulmonologist can assess endosonography-derived lymph node samples after a comprehensive and reproducible training provided by a specialist pathologist.

Methods: Prospective, observational trial structured in three phases. Read More

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http://dx.doi.org/10.1159/000496549DOI Listing
April 2019
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Sarcoidosis and idiopathic pulmonary fibrosis: The same tale or a tale of two diseases in one.

Respir Med 2019 Apr 1. Epub 2019 Apr 1.

Center for Interstitial Lung Diseases, Division of Pulmonary and Critical Care and Sleep Medicine, University of Washington Medical Center, Seattle, WA, 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2019.03.021DOI Listing
April 2019
2 Reads

Translation and psychometric properties of the King's Sarcoidosis Questionnaire (KSQ) in German language.

Health Qual Life Outcomes 2019 Apr 11;17(1):62. Epub 2019 Apr 11.

Department of Pneumology, Faculty of Medicine, Medical Center- University of Freiburg, Freiburg, Germany.

Background: King's Sarcoidosis Questionnaire (KSQ) is a novel, validated, health-related quality of life questionnaire on sarcoidosis with 5 scales and 29 items. For future multinational observational and interventional studies on sarcoidosis, a validated German version of the KSQ is needed. The objective of our study is to translate the original KSQ and develop a German version possessing good psychometric properties and with as few modifications as possible. Read More

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http://dx.doi.org/10.1186/s12955-019-1131-zDOI Listing
April 2019
3 Reads

Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure.

Int J Environ Res Public Health 2019 Apr 10;16(7). Epub 2019 Apr 10.

Department of Medicine, New York University, New York, NY 10016, USA.

: Sarcoidosis is a granulomatous disease involving intrathoracic and extrathoracic organs. Genetic and environmental factors, such as exposure to World-Trade Center (WTC) dust after 9/11, may play a role in clinical presentation. Characterization of sarcoidosis in community members with exposure to the WTC dust can provide further insight into the relationship between environmental exposure and sarcoidosis. Read More

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https://www.mdpi.com/1660-4601/16/7/1291
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http://dx.doi.org/10.3390/ijerph16071291DOI Listing
April 2019
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Minimally invasive biventricular mechanical circulatory support with Impella pumps as a bridge to heart transplantation: a first-in-the-world case report.

ESC Heart Fail 2019 Apr 9. Epub 2019 Apr 9.

Section of Heart Failure and Cardiac Transplant Medicine, Kaufman Center for Heart Failure Treatment and Recovery, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J3-4, Cleveland, OH, 44195, USA.

Cardiogenic shock from biventricular failure that requires acute mechanical circulatory support carries high 30 day mortality. Acute mechanical circulatory support can serve as bridge to orthotopic heart transplant (OHT) in selected patients. We report a patient with biventricular failure secondary to rapidly progressive cardiac sarcoidosis refractory to medical management who was bridged to OHT with Impella 5. Read More

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http://dx.doi.org/10.1002/ehf2.12412DOI Listing
April 2019
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Small-fiber neuropathy definition, diagnosis, and treatment.

Neurol Sci 2019 Apr 9. Epub 2019 Apr 9.

Laboratory of the Mosaic of Autoimmunity, Federal State Budget Educational Institution of Higher Education "St. Petersburg State University", University Emb., 7-9, Saint-Petersburg, Russia, 199034.

In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. Read More

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http://dx.doi.org/10.1007/s10072-019-03871-xDOI Listing
April 2019
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Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study.

Ann Rheum Dis 2019 Apr 9. Epub 2019 Apr 9.

Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.

Objective: To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice.

Methods: We performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214816DOI Listing
April 2019
1 Read
10.377 Impact Factor

Correction to: The Burden of Sarcoidosis Symptoms from a Patient Perspective.

Lung 2019 Apr 8. Epub 2019 Apr 8.

ILD Center of Excellence, Department of Pulmonology, St. Antonius Hospital, PO Box 2400, 3430 VB, Nieuwegein, The Netherlands.

The original version of this article unfortunately contained a mistake in coauthor's given name. The abbreviated given name "M.D. Read More

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http://link.springer.com/10.1007/s00408-019-00221-8
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http://dx.doi.org/10.1007/s00408-019-00221-8DOI Listing
April 2019
5 Reads

Scar Sarcoidosis 10 Years After Videothoracoscopy: Incidental Diagnosis at FDG-PET-CT.

Arch Bronconeumol 2019 Apr 5. Epub 2019 Apr 5.

Nuclear Medicine Department. Hospital Universitario Araba.

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http://dx.doi.org/10.1016/j.arbres.2019.02.017DOI Listing
April 2019
2 Reads

Use of red cell distribution width in a population at high risk for pulmonary hypertension.

Respir Med 2019 Apr 16;150:131-135. Epub 2019 Mar 16.

Comprehensive Pulmonary Hypertension Center-University Medical Center, New Orleans, LA, USA; Louisiana State University Health Sciences Center, Section of Pulmonary/Critical Care and Allergy/Immunology, New Orleans, LA, USA. Electronic address:

Background: Pulmonary hypertension (PH) often presents with non-specific symptoms making early diagnosis difficult. Red cell distribution width (RDW) is a parameter routinely reported on an automated complete blood cell count that has been associated with numerous disease states. The purpose of this study was to further evaluate RDW as a biomarker for PH in at-risk populations. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461373PMC
April 2019
1 Read

The effects of High- versus Moderate-Intensity Exercise on Fatigue in Sarcoidosis.

J Clin Med 2019 Apr 5;8(4). Epub 2019 Apr 5.

LHL Hospital Gardermoen, 2067 NO Jessheim, Norway.

Background: Fatigue is a common symptom in patients with sarcoidosis. Despite lacking evidence on whether high-intensity interval training (HIIT) will aggravate fatigue, moderate-intensity exercise is often recommended. This study aimed to investigate whether a single session of HIIT would affect fatigue differently from a single session of moderate-intensity continuous training (MICT). Read More

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https://www.mdpi.com/2077-0383/8/4/460
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http://dx.doi.org/10.3390/jcm8040460DOI Listing
April 2019
3 Reads

Neck Ultrasound for the Detection of Cervical Lymphadenopathy in Sarcoidosis: An Alternative to Endobronchial Ultrasound.

J Bronchology Interv Pulmonol 2019 Apr 4. Epub 2019 Apr 4.

Department of Respiratory Medicine, Plymouth University Hospitals NHS Trust, Plymouth, UK.

Background: Sarcoidosis is diagnosed by demonstration of granulomatous inflammation and exclusion of other potential causes. Lung parenchyma and intrathoracic lymph nodes are currently the commonest sites from which tissue is obtained in clinical practice, but historically scalene lymph node biopsy was the procedure of choice for diagnosing sarcoidosis in many institutions.

Aim: We aimed to assess the utility of neck ultrasound (NUS) and cervical lymph node needle sampling among patients with stage 1 and 2 sarcoidosis. Read More

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http://dx.doi.org/10.1097/LBR.0000000000000588DOI Listing
April 2019
2 Reads

Sarcoidosis following escalated BEACOPP chemotherapy for stage IV Hodgkin lymphoma.

Intern Med J 2019 Apr;49(4):547-548

Department of Haematology, Nepean Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/imj.14246DOI Listing
April 2019
1 Read

First patient-centred set of outcomes for pulmonary sarcoidosis: a multicentre initiative.

BMJ Open Respir Res 2019 18;6(1):e000394. Epub 2019 Feb 18.

Department of Value-Based Healthcare, St. Antonius Hospital, Nieuwegein, The Netherlands.

Introduction: Routine and international comparison of clinical outcomes enabling identification of best practices for patients with pulmonary sarcoidosis is lacking. The aim of this study was to develop a standard set of outcome measures for pulmonary sarcoidosis, using the value-based healthcare principles.

Methods: Six expert clinics for interstitial lung diseases in four countries participated in a consensus-driven RAND-modified Delphi study. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424298PMC
February 2019
1 Read

Sarcoidosis in the UK: insights from British Thoracic Society registry data.

BMJ Open Respir Res 2019 18;6(1):e000357. Epub 2019 Feb 18.

Department of Respiratory Medicine, Hammersmith Hospital, London, UK.

Introduction: The British Thoracic Society Sarcoidosis Registry allows physicians to record clinical data after gaining written consent from patients. The registry's aim is to phenotype sarcoidosis in the UK.

Methods: Between February 2013 and July 2017, demographic details for 308 patients (with complete clinical data for 205 patients) presenting to 24 UK hospitals were recorded. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424275PMC
February 2019
1 Read

A Unique Case of Complete Atrioventricular Block Rapidly Progressing to Diastolic and Systolic Dysfunction in Cardiac Sarcoidosis.

Case Rep Med 2019 6;2019:4341098. Epub 2019 Mar 6.

Internal Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL 60612, USA.

Sarcoidosis is a multisystem granulomatous disease that most commonly affects the lungs but can affect other organs including the heart due to granuloma infiltration. Atrioventricular block is a common manifestation of cardiac sarcoidosis which can progress to sudden cardiac death. We report a case of cardiac sarcoidosis presenting as complete heart block, progressing to diastolic and systolic dysfunction without extracardiac manifestations early in the disease. Read More

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http://dx.doi.org/10.1155/2019/4341098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431385PMC
March 2019
1 Read

Sarcoidosis.

Med Clin North Am 2019 May 21;103(3):527-534. Epub 2019 Feb 21.

Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Sarcoidosis is a multisystemic granulomatous disease that affects individuals worldwide. The lungs are most commonly involved but any organ can be involved. It has variable manifestations and clinical course. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.12.011DOI Listing
May 2019
2 Reads

Thrombocytopenia recovered by surgical resection of a myxoma.

J Cardiol Cases 2019 Mar 20;19(3):97-100. Epub 2018 Dec 20.

Department of Cardiovascular Surgery, Takamatsu Red Cross Hospital, Takamatsu, Japan.

Myxoma is the most common primary cardiac neoplasm, and causes a variety of symptoms, including hematological disorder. An 82-year-old man with anorexia was diagnosed with a gastrointestinal stromal tumor. Computed tomography and echocardiography showed a 2-cm tumor in the left atrium. Read More

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http://dx.doi.org/10.1016/j.jccase.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429533PMC
March 2019
2 Reads

Sarcoidosis and the Liver.

Clin Liver Dis 2019 May 2;23(2):331-343. Epub 2019 Mar 2.

Division of Gastroenterology, University of South Alabama College of Medicine, UCOM 6000, 75 University Boulevard South, Mobile, AL 36688, USA. Electronic address:

Hepatic granulomas are a common finding in systemic sarcoidosis, but most patients remain asymptomatic. Elevated alkaline phosphatase is the most common sign of hepatic sarcoidosis (HS). Lacking a specific diagnostic test, the diagnosis of HS is one of exclusion. Read More

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http://dx.doi.org/10.1016/j.cld.2018.12.012DOI Listing
May 2019
1 Read

18FDG PET for Detecting Renal Granulomatous Localization: Illustration of Granulomatosis With Polyangiitis and Sarcoidosis.

J Clin Rheumatol 2019 Apr 3. Epub 2019 Apr 3.

AP-HP, Sorbonne Université Hôpital Saint Antoine Service de Médecine Interne and Inflammation-Immunopathology-Biotherapy Department, Paris Service de Médecine Nucléaire Université Paris 13, Bobigny, France AP-HP, Sorbonne Université Hôpital Saint Antoine Service de Médecine Interne and Inflammation-Immunopathology-Biotherapy Department, Paris

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http://dx.doi.org/10.1097/RHU.0000000000001003DOI Listing

HIF-1α regulates IL-1β and IL-17 in sarcoidosis.

Elife 2019 Apr 4;8. Epub 2019 Apr 4.

Department of Internal Medicine, Wayne State University, Detroit, United States.

Sarcoidosis is a complex systemic granulomatous disease of unknown etiology characterized by the presence of activated macrophages and Th1/Th17 effector cells. Data mining of our RNA-Seq analysis of CD14 monocytes showed enrichment for metabolic and hypoxia inducible factor (HIF) pathways in sarcoidosis. Further investigation revealed that sarcoidosis macrophages and monocytes exhibit higher protein levels for HIF-α isoforms, HIF-1β, and their transcriptional co-activator p300 as well as glucose transporter 1 (Glut1). Read More

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http://dx.doi.org/10.7554/eLife.44519DOI Listing
April 2019
2 Reads

Phosphoinositide 3-kinase/protein kinase B inhibition restores regulatory T cell's function in pulmonary sarcoidosis.

J Cell Physiol 2019 Apr 3. Epub 2019 Apr 3.

Department of Basic Medicine, Center of Translational Medicine, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School, Nanjing, China.

Sarcoidosis is a systemic granulomatous disease associated with Th1/ regulatory T cells (Treg) paradigm. PI3K/Akt signaling, critical for maintaining Treg's homeostasis, is aberrantly activated in sarcoidosis patients. Here we tested the role of the PI3K inhibitors, LY294002 and BKM120, in immune modulation in experimental pulmonary sarcoidosis, concerning Th1/Th17/Treg immune profile detected by fluorescence-activated cell sorting analysis or quantitative polymerase chain reaction, as well as the effect on Treg's suppressive functions. Read More

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http://dx.doi.org/10.1002/jcp.28589DOI Listing
April 2019
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Prognostic insights of molecular imaging in cardiac sarcoidosis.

J Nucl Cardiol 2019 Apr 3. Epub 2019 Apr 3.

Department of Biomedical and Dental Sciences and of Morpho-functional Imaging, Nuclear Medicine Unit, University of Messina, Via Consolare Valeria n.1, Messina, ME, Italy.

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http://dx.doi.org/10.1007/s12350-019-01701-3DOI Listing
April 2019
3 Reads

Prognostic Biomarkers of Sarcoidosis: A Comparative Study of Serum Chitotriosidase, ACE, Lysozyme, and KL-6.

Dis Markers 2019 3;2019:8565423. Epub 2019 Mar 3.

Department of Clinical Medicine and Immunological Sciences, Respiratory Disease and Lung Transplant Unit, Respiratory Diseases and Transplant Unit, Siena University, Siena, Italy.

Purpose: Sarcoidosis is a systemic granulomatous disease with unknown etiology. Many clinical presentations have been reported, and acute disease needs to be distinguished from subacute and chronic disease. The unpredictable clinical course of the disease prompted us to evaluate the clinical utility of biomarker serum detection in sarcoidosis follow-up. Read More

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http://dx.doi.org/10.1155/2019/8565423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421736PMC
March 2019
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Peritoneal sarcoidosis mimicking peritoneal carcinomatosis.

Ann Ital Chir 2019 Jan 10;8. Epub 2019 Jan 10.

Aim: Describtion of a rare case of intestinal obstruction due to peritoneal sarcoidosis mimicking peritoneal carcinomatosis, and of the literature review about its surgical management.

Material Of Study: A 69 year-old woman was referred to our emergency department with diffuse abdominal pain, enteric vomiting and constipation. Abdominal CT showed a dilatated small bowel loops extended to the jejunum with a mechanical obstruction. Read More

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January 2019
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The Sudden Development of Multi-Organ Lesions in a Patient With Pulmonary Sarcoidosis: A Case Report.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619836139

1 University of South Dakota, Sioux Falls, SD, USA.

Introduction: Sarcoidosis is a systemic granulomatous inflammatory disease that can involve almost any organ system in the human body. It most frequently presents with pulmonary infiltrates, hilar lymphadenopathy, and skin lesions. Clinical and subclinical involvement of other organ systems is not uncommon. Read More

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http://journals.sagepub.com/doi/10.1177/2324709619836139
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http://dx.doi.org/10.1177/2324709619836139DOI Listing
April 2019
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Mycobacterium Avium Complex Presenting as Pulmonary Nodules in a Child With Sickle Cell Disease.

J Pediatr Hematol Oncol 2019 Mar 29. Epub 2019 Mar 29.

Departments of Pediatrics, Texas A&M Health Science Center, Scott & White Medical Center-Temple, Temple, TX.

The case of a 10-year-old child with sickle cell disease with pulmonary nodules and prolonged fevers is reported here. The child was first diagnosed with sarcoidosis based on lung biopsy, but unresponsiveness to therapy led to a second lung biopsy, which revealed the true diagnosis of mycobacterium avium complex disease. Multiple possible explanations for why the patient became infected exist. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001458DOI Listing
March 2019
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Relapsing lumbosacral myeloradiculitis: An unusual presentation of MOG antibody disease.

Mult Scler 2019 Apr 1:1352458519840747. Epub 2019 Apr 1.

Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Thiruvananthapuram, India.

Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) seropositivity is being increasingly reported in diverse demyelinating syndromes with monophasic and relapsing presentations. Conus myelitis is described as a typical feature of MOG-Ab seropositivity. However, the association with lumbosacral radiculitis in this disease is not well-recognized. Read More

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http://dx.doi.org/10.1177/1352458519840747DOI Listing
April 2019
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[A case of muscle sarcoidosis with hypercalcemia, lower limb muscle strength and without bilateral hilar lymphadenopathy].

Rinsho Shinkeigaku 2019 Mar 30. Epub 2019 Mar 30.

Department of Internal Medicine, Division of Neurology, Hyogo College of Medicine.

A 73-year-old man was hospitalized with complaints of general malaise, limb muscle weakness and weight loss progressing in 6 months. Ca, ACE, lysozyme, sIL-2R, vitamin 1.25 D was high in the blood test. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001256DOI Listing
March 2019
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Why does it take so long? The reasons behind tuberculosis treatment delay in Portugal.

Pulmonology 2019 Mar 28. Epub 2019 Mar 28.

EPIUnit: Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal; Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal; Pneumology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal; Chest Disease Center, Vila Nova de Gaia, Portugal.

Introduction: Delayed diagnosis and treatment of tuberculosis contributes to the spread of the disease. In this study, we aimed to determine the patient and healthcare system delay among tuberculosis patients in Portugal and identify associated factors at individual and contextual level.

Methods: We analysed all TB cases notified in Portugal between 2010 and 2014 using data from the national surveillance system. Read More

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http://dx.doi.org/10.1016/j.pulmoe.2019.02.005DOI Listing
March 2019
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Combined sarcoidosis and idiopathic pulmonary fibrosis (CSIPF): A novel disease phenotype?

Respir Med 2019 Mar 16. Epub 2019 Mar 16.

Respiratory Diseases and Lung Transplantation, Department of Medical and Surgical Sciences & Neurosciences, Siena University Hospital, Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2019.02.022DOI Listing
March 2019
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Tonsillar and Adenoid Noncaseating, Epithelioid Granulomas in a Young Girl.

J Craniofac Surg 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology-Head and Neck Surgery, Samson Assuta Ashdod University Hospital, Ben Gurion University Faculty of Health Sciences, Ashdod, Israel.

Waldeyer's lymphatic ring granulomas in children are infrequent, and may represent an underlying systemic disease, often nondiagnosed before adenotonsillectomy is performed. The authors report on a 5-year-old otherwise healthy girl presented with remarkable tonsillar asymmetry as well as adenoid hypertrophy, with no systemic signs or complaints. Adenotonsillectomy was performed to rule out malignancy. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005415DOI Listing
March 2019
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0.676 Impact Factor

Foreign-Body Granulomata Caused by Injected Permanent Filler Masquerading as Cutaneous Sarcoidosis.

Ophthalmic Plast Reconstr Surg 2019 Mar 26. Epub 2019 Mar 26.

Department of Ophthalmology, UT Southwestern Medical Center.

Foreign-body granuloma formation following filler injections is most commonly seen with permanent fillers; these reactions can occur years following the injections and often require either an intralesional steroid injection or surgical excision. The authors present a case of a 75-year-old woman with a history of systemic sarcoidosis previously treated with numerous immunosuppressive medications who was examined for bilateral infraorbital nodules and swelling that were unresponsive to treatment. She underwent a bilateral anterior orbitotomy through a transconjunctival approach with mass excision. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001385DOI Listing
March 2019
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