29,484 results match your criteria Sarcoidosis


The Burden of Sarcoidosis Symptoms from a Patient Perspective.

Lung 2019 Feb 16. Epub 2019 Feb 16.

ILD Center of Excellence, Department of Pulmonology, St. Antonius Hospital, PO Box 2400, 3430 VB, Nieuwegein, The Netherlands.

Purpose: The clinical manifestations of sarcoidosis vary widely, depending on the intensity of the inflammation and the organ systems affected. Hence, sarcoidosis patients may suffer from a great variety of symptoms. The aim of this study was to compare the self-reported burden of sarcoidosis patients in Denmark, Germany and the Netherlands, especially the prevalence of fatigue and small fiber neuropathy (SFN)-related symptoms, as well as differences in treatment strategies. Read More

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http://dx.doi.org/10.1007/s00408-019-00206-7DOI Listing
February 2019

Sarcoidosis: No longer a benign disease?

Authors:
Alicia K Gerke

Respir Med 2019 Feb 6. Epub 2019 Feb 6.

University of Iowa, Pulmonary and Critical Care Medicine, 200 Hawkins Dr. C33-GH, Iowa City, IA, 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2019.02.002DOI Listing
February 2019

The cumulative incidence and trends of rare diseases in South Korea: a nationwide study of the administrative data from the National Health Insurance Service database from 2011-2015.

Orphanet J Rare Dis 2019 Feb 18;14(1):49. Epub 2019 Feb 18.

The Institute for Occupational Health, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: The burden of rare diseases on society and patients' families has increased in Korea. However, because of the infrequency of rare diseases, there is a lack of resources and information to address these cases and inadequate funding for the management of these patients. We investigated the average annual cumulative incidence of rare diseases and the trends in annual cumulative incidence from 2011 to 2015 in Korea by using nationwide administrative data from the Korean National Health Insurance Service (NHIS) database for patients registered with the co-payment assistance policy for rare and incurable diseases. Read More

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https://ojrd.biomedcentral.com/articles/10.1186/s13023-019-1
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http://dx.doi.org/10.1186/s13023-019-1032-6DOI Listing
February 2019
1 Read

Primary Oral Presentation of Sarcoidosis in a Pediatric Patient.

J Oral Maxillofac Surg 2019 Jan 23. Epub 2019 Jan 23.

Associate Professor, Department of Pediatric Rheumatology, Children's of Alabama, Birmingham, AL.

Sarcoidosis is a multisystem granulomatous disease of unknown etiology that commonly affects the lungs, lymph nodes, and skin. The disease often presents in patients between the third and sixth decade and its pathology is defined by the presence of noncaseating granulomas within organs throughout the body. Oral and neurologic involvement of sarcoid is extremely rare and occurs in approximately 1% and 5% of patients with the disease, respectively. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.018DOI Listing
January 2019

Diagnostic performance of F FDG PET in cardiac sarcoidosis: Are we getting closer to the truth?

J Nucl Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1007/s12350-019-01653-8DOI Listing
February 2019

Imaging cardiac sarcoidosis with FDG-PET: Take a look at the right side!

J Nucl Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Nuclear Medicine, Centre Hospitalier Universitaire Bichat, Assistance Publique - Hôpitaux de Paris, Inserm 1148, Université Paris Diderot, Paris, France.

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http://dx.doi.org/10.1007/s12350-019-01645-8DOI Listing
February 2019

Glucocorticoid Treatment of Symptomatic Sarcoidosis in 2 Morbidly Obese Patients.

Fed Pract 2019 Jan;36(1):36-40

is a Resident Physician in the Internal Medicine Department at New York Presbyterian/Weill Cornell Medical College in New York City. is a Fellow Physician, and is a Clinical Professor of Medicine, both in the Division of Pulmonary, Allergy, and Critical Care Medicine at the Hospital of the University of Pennsylvania in Philadelphia. Mitchell Margolis also is Chief of Pulmonary and Critical Care Section at the Michael J. Crescenz Veterans Affairs Medical Center in Philadelphia.

Corticosteroid management for patients with sarcoidosis requires the need for close monitoring to detect and manage any complications that may arise during treatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366578PMC
January 2019

Radiologic Manifestations of Musculoskeletal Sarcoidosis.

Curr Rheumatol Rep 2019 Feb 14;21(3). Epub 2019 Feb 14.

Department of Radiology, Escola Paulista de Medicina, Federal University of Sao Paulo (UNIFESP), São Paulo, Brazil.

Purpose Of Review: The purpose of this review article is to present the spectrum of abnormalities and multi-modality imaging evaluations in patients with musculoskeletal sarcoidosis.

Recent Findings: The articular manifestations of sarcoidosis are difficult to distinguish from those of the other inflammatory and degenerative arthropathies, and the muscular lesions in sarcoidosis are generally clinically silent and therefore often missed. Magnetic resonance imaging has shown these manifestations to be very common in active sarcoidosis, and should thus be included in the screening if musculoskeletal sarcoidosis is suspected. Read More

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http://dx.doi.org/10.1007/s11926-019-0806-0DOI Listing
February 2019
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Expression of interleukin (IL)-10 family cytokines in aqueous humour of patients with specific endogenous uveitic entities: elevated levels of IL-19 in human leucocyte antigen-B27-associated uveitis.

Acta Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.

Purpose: Evidence exists that the interleukin (IL)-10 family of cytokines is involved in autoimmune diseases. The aim of this study was to analyse the levels of the IL-10 family cytokines IL-10, IL-19, IL-20, IL-22, IL-26, IL-28A and IL-29 in aqueous humour (AH) samples from patients with specific uveitic entities. In addition, we correlated their levels with the levels of the proinflammatory cytokines tumour necrosis factor-α (TNF-α) and IL-1β. Read More

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http://dx.doi.org/10.1111/aos.14039DOI Listing
February 2019

Yield of screening blood work and MRI of the brain and orbits in the work-up of unilateral chronic optic neuropathy.

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.

Background/objectives: No guidelines exist for the investigation of treatable causes of chronic optic neuropathy, including sarcoidosis, lupus, and syphilis. The purpose of this study was to determine the diagnostic yield of screening blood work (ACE (Angiotensin Converting Enzyme) for sarcoidosis, Antinuclear Antibodies (ANA) for lupus, CMIA (chemiluminescence microparticle enzyme immunoassay) for syphilis) and contrast-enhanced MRI brain and orbits in atypical unilateral chronic optic neuropathy.

Subjects/methods: Retrospective review from February 2012 to June 2018 at a neuro-ophthalmology practice. Read More

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http://dx.doi.org/10.1038/s41433-018-0326-6DOI Listing
February 2019
1 Read

NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis.

BMC Pulm Med 2019 Feb 13;19(1):39. Epub 2019 Feb 13.

Department of Pulmonology, Hospital de São João and Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Diffuse lung diseases (DLD) are characterized by different immunophenotypes in the bronchoalveolar lavage fluid (BALF). We aimed to evaluate the diagnostic value of BALF NK and NKT cell counts of patients with DLD and lymphocytic alveolitis.

Methods: We assessed 202 patients with DLD, who underwent BALF immunophenotyping. Read More

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http://dx.doi.org/10.1186/s12890-019-0802-1DOI Listing
February 2019
2 Reads

Idiopathic granulomatous mastitis.

Cutis 2019 Jan;103(1):38-42

Department of Dermatology, Massachusetts General Hospital, Boston, USA.

Idiopathic granulomatous mastitis (IGM) is a rare, poorly understood condition that presents as inflammatory nodules of the breast. It is often initially misdiagnosed as furunculosis or cellulitis. Despite the painful, scarring, and debilitating nature of the disease, patients often have a delay in accurate diagnosis and treatment. Read More

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January 2019
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A Rare Case of Spinal Sarcoidosis Presenting as Multiple Bone Marrow Oedematous Lesions.

Eur J Case Rep Intern Med 2018 28;5(8):00907. Epub 2018 Aug 28.

Department of Internal Medicine "C", Assaf Harofeh Medical Center, affiliated to Sackler Medical School, Tel Aviv University, Zerifin, Israel.

Sarcoidosis is a systemic disorder that most commonly affects the lungs. Bone involvement is rare, and spinal involvement is even more rare. The presence of focal lesions of the vertebrae is highly suspicious of advanced malignancy. Read More

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http://dx.doi.org/10.12890/2018_00907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346829PMC

Cryptococcal Meningitis in a HIV-Negative Patient.

Eur J Case Rep Intern Med 2018 22;5(2):000778. Epub 2018 Feb 22.

Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal.

Sarcoidosis is a risk factor for the development of cryptococcal infection due to dysfunction at T-cell level. Its rarity may, however, delay diagnosis and treatment. We describe the case of a 60-year-old man, diagnosed with sarcoidosis since 1999. Read More

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http://dx.doi.org/10.12890/2017_000778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346933PMC
February 2018
1 Read

Systemic Sarcoidosis Associated with Exposure to in a 21-Year-Old Man.

Eur J Case Rep Intern Med 2018 24;5(10):000942. Epub 2018 Oct 24.

Gelre Ziekenhuizen, Apeldoorn, The Netherlands.

Objective: Here we describe a rare case of systemic sarcoidosis in a healthy young man with neuroborreliosis as a putative trigger.

Case: A 21-year-old forestry worker was diagnosed with systemic sarcoidosis involving his lungs, kidneys and skin. Additional diagnostics revealed signs indicative of a recent infection with . Read More

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http://dx.doi.org/10.12890/2018_000942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346892PMC
October 2018

'When you hear hooves, think zebras, not horses'; two challenging cases of interstitial lung disease (ILD).

BMJ Case Rep 2019 Feb 11;12(2). Epub 2019 Feb 11.

Department of Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland.

Our case series describes two siblings with complex fibrosing lung diseases. The first patient was initially given a diagnosis of sarcoidosis based on imaging and exclusion of alternative diagnoses. A number of years after diagnosis, he had rapid deterioration of his disease and following surgical lung biopsy, his lung fibrosis was re-classified as chronic hypersensitivity pneumonitis (cHP) with a usual interstitial pneumonia pattern. Read More

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http://dx.doi.org/10.1136/bcr-2018-224507DOI Listing
February 2019
2 Reads

Microparticles in systemic sclerosis: Potential pro-inflammatory mediators and pulmonary hypertension biomarkers.

Respirology 2019 Feb 12. Epub 2019 Feb 12.

Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Background And Objective: Endothelial microparticles (EMP) are submicron vesicles released from endothelial cells. We aimed to determine the utility of EMP as biomarkers of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) patients and the pathogenic role of microparticles (MP) in vascular inflammation.

Methods: Levels of EMP (CD144+, CD31+, CD62E+ and CD143+) were compared between three groups (10 SSc patients with PAH, 10 SSc patients without pulmonary hypertension (no-PH) and 10 healthy age- and sex-matched controls). Read More

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http://dx.doi.org/10.1111/resp.13500DOI Listing
February 2019
2 Reads

Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: Techniques and Challenges.

J Cytol 2019 Jan-Mar;36(1):65-70

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Intrathoracic lymphadenopathy is a common problem encountered in clinical practice and is caused by a wide variety of diseases. Traditionally, the mediastinal lymph nodes were sampled using conventional transbronchial needle aspiration (TBNA), or surgical methods such as mediastinoscopy, and thoracotomy (open or video-assisted thoracoscopy). However, surgical modalities including mediastinoscopy are invasive, expensive, and not universally available. Read More

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http://dx.doi.org/10.4103/JOC.JOC_171_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343395PMC
February 2019
1 Read

Mapping mononuclear phagocytes in blood, lungs, and lymph nodes of sarcoidosis patients.

J Leukoc Biol 2019 Feb 11. Epub 2019 Feb 11.

Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Sarcoidosis is a T-cell driven inflammatory disease characterized by granuloma formation. Mononuclear phagocytes (MNPs)-macrophages, monocytes, and dendritic cells (DCs)-are likely critical in sarcoidosis as they initiate and maintain T cell activation and contribute to granuloma formation by cytokine production. Granulomas manifest primarily in lungs and lung-draining lymph nodes (LLNs) but these compartments are less studied compared to blood and bronchoalveolar lavage (BAL). Read More

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http://doi.wiley.com/10.1002/JLB.5A0718-280RR
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http://dx.doi.org/10.1002/JLB.5A0718-280RRDOI Listing
February 2019
3 Reads

PPARγ Deficiency Exacerbates Fibrotic Response to Mycobacteria Peptide in Murine Sarcoidosis Model.

Am J Respir Cell Mol Biol 2019 Feb 11. Epub 2019 Feb 11.

East Carolina University, Dept of Internal Medicine, Greenville, North Carolina, United States ;

We established a murine model of multiwall carbon nanotube (MWCNT)-elicited chronic granulomatous disease which bears similarities to human sarcoidosis pathology including alveolar macrophage deficiency of peroxisome-proliferator-activated receptor gamma (PPARγ). Because lymphocyte reactivity to mycobacterial antigens has been reported in sarcoidosis, we hypothesized that addition of mycobacterial Early Secreted Antigenic Target Protein 6 (ESAT-6) to MWCNT might exacerbate pulmonary granulomatous pathology. MWCNT with or without ESAT-6 peptide-14 were instilled by oropharyngeal route into macrophage-specific PPARγ KO or wild-type mice. Read More

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http://dx.doi.org/10.1165/rcmb.2018-0346OCDOI Listing
February 2019
1 Read

Using FDG-PET to guide targeted cardiac magnetic resonance imaging in patients with suspected cardiac sarcoidosis.

J Nucl Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Section of Cardiovascular Medicine, Yale School of Medicine, 333 Cedar Street, PO Box 208017, New Haven, CT, 06520-8017, USA.

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http://link.springer.com/10.1007/s12350-019-01640-z
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http://dx.doi.org/10.1007/s12350-019-01640-zDOI Listing
February 2019
2 Reads

Echogenic lymph nodes in the differential diagnosis of pediatric sarcoidosis.

J Med Ultrason (2001) 2019 Feb 8. Epub 2019 Feb 8.

Pediatric Rheumatology Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

We present a delayed diagnosis of sarcoidosis in an 11-year-old girl by demonstrating ultrasonographic imaging findings of granulomatous cervical and abdominal lymph node involvement. Pulmonary interstitial fibrosis in addition to multi-compartmental enlarged echogenic lymph nodes could be considered sarcoidosis. Punctate echogenic foci in the cervical lymph nodes should be considered in the differential diagnosis of sarcoidosis. Read More

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http://dx.doi.org/10.1007/s10396-019-00932-8DOI Listing
February 2019
1 Read

Pulmonary sarcoidosis as a cause of intermittent fever of unknown origin in a hemodialysis patient with renal cell carcinoma: A case report and literature review.

Hemodial Int 2019 Feb 7. Epub 2019 Feb 7.

Department of Kidney Disease, Kawashima Hospital, 1-39 Kitasakoichiban-cho, Tokushima, 770-0011, Japan.

Hemodialysis patients have weakened immune systems and can exhibit fever due to various causes. Herein, we describe the case of a 61-year-old hemodialysis patient who exhibited intermittent low-grade fever after a pacemaker had been implanted 2 months before due to sick sinus syndrome. She had a medical history of subcutaneous sarcoidosis and uveitis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hdi.12695
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http://dx.doi.org/10.1111/hdi.12695DOI Listing
February 2019
3 Reads

In-vivo assessment of a case of cutaneous sarcoidosis using reflectance confocal microscopy.

An Bras Dermatol 2019 Jan-Feb;94(1):93-95

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America.

Reflectance confocal microscopy (RCM) is a noninvasive imaging technique that allows visualization of the epidermis and papillary dermis with cellular-level resolution. Granulomatous reactions such as sarcoidosis could be assessed using RCM. The identification of bright beaded-like structures that could correspond to reticulin fibers overlying granulomas, in association with dermoscopy, may be a very useful approach in the diagnosis of sarcoidosis and for the differentiation of this granulomatous entity with superficial cutaneous metastasis. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360958PMC
May 2017
1 Read

Bidirectional association between tuberculosis and sarcoidosis.

Respirology 2019 Feb 5. Epub 2019 Feb 5.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background And Objective: Tuberculosis (TB) and sarcoidosis are both granulomatous diseases with potential interassociations. However, much uncertainty remains; thus, the present study aimed to clarify the association between these diseases.

Methods: We established two cohorts in this retrospective longitudinal cohort study using data obtained from the Taiwan National Health Insurance Database from 2000 to 2015. Read More

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http://dx.doi.org/10.1111/resp.13482DOI Listing
February 2019
2 Reads

Rejection in heart transplantation for cardiac sarcoidosis mimicking idiopathic giant cell myocarditis: long-term follow-up.

J Cardiovasc Med (Hagerstown) 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiothoracic Science, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.

: Heart transplantation is a life-saving therapy for some patients admitted for acute myocarditis. However, controversial exists about the major risk of rejection following heart transplantation in specific types of myocarditis. Because of relatively few data on the post heart transplant outcomes, we report the long-term follow-up of a 39-year-old patient with a previous history of ulcerative colitis, which rapidly worsened heart failure until an emergency heart transplant in 2004. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000772DOI Listing
January 2019
2 Reads

Takayasu's Arteritis and Sarcoidosis in the Era of Advanced Molecular Imaging.

Arthritis Rheumatol 2019 Feb 4. Epub 2019 Feb 4.

National Institutes of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland, 20892, USA.

A 32-year-old woman with a history of Takayasu's arteritis (TAK) was enrolled into an ongoing vascular imaging research study. She was diagnosed with TAK four years earlier based on vascular headache, arm claudication, and severe aortic arch disease. She had no complaints at the time of enrollment. Read More

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http://dx.doi.org/10.1002/art.40847DOI Listing
February 2019
2 Reads

Multiple Sclerosis and Autoimmune Neurology of the Central Nervous System.

Med Clin North Am 2019 Mar 3;103(2):325-336. Epub 2018 Dec 3.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

Autoimmune disorders of the central nervous system are common and often affect people in the most productive years of their lives. Among primary autoimmune diseases of the central nervous system, multiple sclerosis is most prevalent in the United States. Many other autoantibody-mediated neurologic syndromes have been identified within the past 2 to 3 decades, including neuromyelitis optica and anti-N-methyl-D aspartate receptor encephalitis. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.10.004DOI Listing
March 2019
1 Read

Clinical significance of the determination of surfactant proteins A and D in assessing the activity of lung sarcoidosis.

Ter Arkh 2018 Apr;90(3):42-46

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To study the clinical significance of SP-A, SP-D in assessing the activity of idiopathic pulmonary fibrosis and sarcoidosis. We examined 81 patients with morphologically confirmed diagnoses of idiopathic pulmonary fibrosis (ILF) and sarcoidosis, a control group of 20 healthy individuals. The MSCT of the thoracic organs of the chest was performed, the diffusivity of the lungs was examined, oxygen saturation was determined. Read More

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http://dx.doi.org/10.26442/terarkh201890342-46DOI Listing
April 2018
1 Read

Expression of DROSHA and DICER genes in peripheral blood leukocytes in lung sarcoidosis.

Ter Arkh 2018 Apr;90(3):21-24

Petrozavodsk state University, Department of Hospital Therapy, Petrozavodsk, Russia.

Aim: To study the expression level of the genes DROSHA and DICER in peripheral blood leukocytes (PBL) of patients with sarcoidosis of the lungs.

Materials And Methods: The study included 32 patients diagnosed with persistent lung sarcoidosis (mean age 41.56±1. Read More

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http://dx.doi.org/10.26442/terarkh201890321-24DOI Listing
April 2018
1 Read

Magnetic resonance imaging of the heart in the diagnosis of sarcoidosis.

Ter Arkh 2018 Dec;90(12):101-106

A.L. Myasnikov Institute of Clinical Cardiology National Cardiology Research Center of the Ministry of Health of the Russian Federation, Moscow, Russia.

Heart sarcoidosis diagnosis presents great difficulties due to the absence of specific clinical manifestations. Most often, the diagnosis is established during autopsy. Magnetic resonance imaging (MRI) of the heart with contrast enhancement is one of the most informative methods of intravital diagnosis of cardiac sarcoidosis. Read More

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http://dx.doi.org/10.26442/00403660.2018.12.000017DOI Listing
December 2018
1 Read

Clinical features of cardiac lesion in patients with generalized sarcoidosis.

Ter Arkh 2018 Feb;90(1):54-59

I.M. Sechenov First Moscow State Medical University, Faculty of Medicine, Chair of Internal Medicine No.1, Moscow, Russia.

The article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial infarction, cholestasis, tubulointerstitial nephritis. The accession of systemic manifestations was accompanied by increase of level of angiotensin-converting enzyme in the blood serum, morphological examination of lung tissue in both cases there were high histological activity of vasculitis and granulomatous inflammation. Read More

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http://dx.doi.org/10.26442/terarkh201890154-59DOI Listing
February 2018
1 Read

Multiple cerebral infarcts: a rare complication of neurosarcoidosis.

Pract Neurol 2019 Jan 30. Epub 2019 Jan 30.

Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

A 52-year-old man experienced a relapse of neurosarcoidosis, characterised by obstructive hydrocephalus and multiple posterior circulation infarcts. He was taking methotrexate, but his prednisolone was being weaned because of adverse effects. Stroke is rare in neurosarcoidosis and typically relates to granulomatous inflammation with a predilection for the perforator arteries. Read More

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http://dx.doi.org/10.1136/practneurol-2018-002133DOI Listing
January 2019
2 Reads

Multiple huge "cluster" and "galaxy" signs on chest radiography in a patient with pulmonary tuberculosis.

Respirol Case Rep 2019 Apr 25;7(3):e00398. Epub 2019 Jan 25.

Department of Respiratory Medicine Kyorin University School of Medicine Mitaka Japan.

A 62-year-old healthy man presented to our hospital due to a persistent fever of up to 38°C for one week. Thoracic computed tomography showed right pleural effusion with multiple large nodules up to 7 cm in diameter composed of numerous discrete small nodules like fireworks, the so-called "cluster" signs. Some of the large nodules had a hyper-dense portion centrally surrounded by partially discrete small nodules, not as densely assembled, suggestive of the "galaxy" sign. Read More

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http://dx.doi.org/10.1002/rcr2.398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346226PMC
April 2019
2 Reads

Herpes zoster presenting as unilateral vasculitis.

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Department of Dermatology, Oregon Health and Science University, Portland, Oregon.

Vasculitis can be a primary disorder or a cutaneous manifestation of a viral infection. The present case describes an atypical localized cutaneous varicella-zoster virus infection inducing a small vessel vasculitis in a patient with multisystem sarcoidosis. Additionally, we discuss the differential diagnoses and treatment options. Read More

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November 2018
1 Read

Management of Arrhythmias Associated with Cardiac Sarcoidosis.

Korean Circ J 2019 Feb;49(2):119-133

Department of Cardiology, Kyorin University School of Medicine, Tokyo, Japan.

Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. The annual incidence of systemic sarcoidosis is estimated at 10-20 per 100,000 individuals. Owing to the recent advances in imaging modalities, cardiac sarcoidosis (CS) is diagnosed more frequently. Read More

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http://dx.doi.org/10.4070/kcj.2018.0432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351276PMC
February 2019
2 Reads

Macular hypopigmentation, hair loss and follicular spongiosis: A distinct clinicopathological entity.

Indian J Dermatol Venereol Leprol 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: Hypopigmented macules are seen in a variety of disorders and the diagnosis rests on clinicopathological correlation. However, some cases are difficult to classify and pose a diagnostic challenge.

Aim: To describe the clinical and histopathological features of patients with hypopigmented macules and follicular spongiosis on histopathology. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_679_17DOI Listing
January 2019
1 Read

Scar sarcoidosis: 11 patients with variable clinical features and invariable pulmonary involvement.

Clin Exp Dermatol 2019 Jan 27. Epub 2019 Jan 27.

Department of Pulmonary Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

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http://dx.doi.org/10.1111/ced.13917DOI Listing
January 2019
1 Read

A unique case of hemi-tongue pseudohypertrophy, necrotizing myopathy, and erythema nodosum.

Neurol Int 2018 Dec 5;10(4):7852. Epub 2018 Dec 5.

Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

A 46-year-old woman developed slowly progressive tongue weakness with a pseudohypertrophic change on the right side of her tongue. She subsequently developed weakness in her proximal lower extremities, skin erythema and a sustained increase of muscle enzymes at 11 M after the onset. A biopsy of the quadriceps muscle showed necrotizing myopathy and a skin biopsy showed erythema nodosum. Read More

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http://dx.doi.org/10.4081/ni.2018.7852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322047PMC
December 2018
1 Read

Thoracic Sarcoidosis: Imaging Patterns.

Semin Roentgenol 2019 Jan 27;54(1):59-65. Epub 2018 Dec 27.

Department of Radiology, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1053/j.ro.2018.12.008DOI Listing
January 2019
2 Reads

Odontoid cervical gout causing atlantoaxial instability: case report.

J Neurosurg Spine 2019 Jan 25:1-4. Epub 2019 Jan 25.

Departments of1Neurosurgery and.

The authors present a case report of a patient discovered to have a rotatory subluxation of the C1-2 joint and a large retroodontoid pannus with an enhancing lesion in the odontoid process eventually proving to be caused by gout. This patient represented a diagnostic conundrum as she had known prior diagnoses of not only gout but also sarcoidosis and possible rheumatoid arthritis, and was in the demographic range where concern for an oncological process cannot fully be ruled out. Because she presented with signs and symptoms of atlantoaxial instability, she required posterior stabilization to reduce the rotatory subluxation and to stabilize the C1-2 instability. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18122DOI Listing
January 2019
6 Reads

Hypertrophic cervical spine pachymeningitis due to sarcoidosis: a case report.

Hosp Pract (1995) 2019 Feb 6:1-5. Epub 2019 Feb 6.

d Pathology , Lehigh Valley Health Network , Allentown , PA , USA.

Hypertrophic pachymeningitis (HP) is a chronic, progressive diffuse inflammatory condition that leads to thickening of the dura mater and can be idiopathic or associated with sarcoidosis among other disorders. In this case report, we present a rare case of cervical spine HP in a 29-year-old woman in the post-partum period, who had a history of pituitary adenoma and juvenile rheumatoid arthritis. Magnetic resonance imaging (MRI) of the spine revealed a soft tissue mass and moderate cord compression. Read More

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https://www.tandfonline.com/doi/full/10.1080/21548331.2019.1
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http://dx.doi.org/10.1080/21548331.2019.1575645DOI Listing
February 2019
8 Reads

Erythema nodosum and sarcoid granulomas - letting the cat out of the bag.

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

Department of Dermatology, Coimbra University Hospital, Coimbra.

A 41-year-old woman presented with a violaceous papule on the dorsum of the hand, large ipsilateral axillary lymphadenopathy, and tender, erythematous, subcutaneous nodules on the legs. Accompanying signs included fever, ankle swelling, and bilateral red eye. She recalled having a previous exposure to kittens one month before and had a positive family history for sarcoidosis. Read More

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December 2018
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The formation and disordered degradation of neutrophil extracellular traps in necrotizing lesions of anti-neutrophil cytoplasmic antibody-associated vasculitis.

Am J Pathol 2019 Jan 21. Epub 2019 Jan 21.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan. Electronic address:

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by the production of ANCAs and systemic necrotizing vasculitis in small vessels. Disordered regulation of neutrophil extracellular traps (NETs) is critically involved in the pathogenesis of AAV. NETs are web-like DNA decorated with antimicrobial proteins; they are extruded from activated neutrophils. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.007DOI Listing
January 2019
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Sarcoidosis Presenting as Acute Respiratory Distress Syndrome.

Case Rep Med 2018 23;2018:6465180. Epub 2018 Dec 23.

Department of Pulmonary and Critical Care Medicine-Jefferson Health, Abington, PA, USA.

Sarcoidosis is a multisystem granulomatous disease of unknown origin. It typically involves the lungs and mediastinal lymph nodes in a chronic fashion. However, acute syndrome has been reported possibly in response to systemic release of proinflammatory cytokines. Read More

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http://dx.doi.org/10.1155/2018/6465180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323477PMC
December 2018
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Primary isolated hepatosplenic sarcoidosis mimicking malignancy and causing symptomatic hypercalcaemia.

BMJ Case Rep 2019 Jan 22;12(1). Epub 2019 Jan 22.

Hurley Medical Center, Flint, Michigan, USA.

This is a case of a 67-year-old woman, known to have multiple medical problems, mainly papillary thyroid cancer status post-total thyroidectomy and cervical neck dissection in addition to radioactive iodine currently in remission for 1 year, who presented to the hospital with severe weakness and fatigue. The initial workup showed significant hypercalcaemia and suppressed Parathyroid hormone (PTH). The patient was treated with hydration and pamidronate and her hypercalcaemia and symptoms improved. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22770
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http://dx.doi.org/10.1136/bcr-2018-227703DOI Listing
January 2019
8 Reads