30,917 results match your criteria Sarcoidosis


A rare case of lupoid leishmaniasis defying diagnosis for a decade.

J Cutan Pathol 2020 Jul 4. Epub 2020 Jul 4.

Yale University School of Medicine Department of Dermatology.

Cutaneous leishmaniasis is a common disease affecting millions in endemic areas worldwide. We present a case of lupoid leishmaniasis, a rare variant of cutaneous leishmaniasis, which clinically mimicked sarcoidosis and/or granulomatous rosacea for ten years until ultimate diagnosis. An 82-year-old U. Read More

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http://dx.doi.org/10.1111/cup.13793DOI Listing

Myocardial hypoattenuation in cardiac sarcoidosis: CT correlation with CMR, PET and SPECT.

Clin Imaging 2020 Jun 15;67:136-142. Epub 2020 Jun 15.

Department of Cardiology, North Shore University Hospital, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY 11030, United States of America; Department of Radiology, North Shore University Hospital, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY 11030, United States of America; Multimodality Cardiovascular Imaging Laboratory, North Shore University Hospital, Manhasset, NY 11030, United States of America. Electronic address:

We report a marked abnormality in myocardial attenuation on non-gated contrast-enhanced CT in a patient with multiorgan sarcoidosis and correlate our findings with CMR, PET and SPECT. The noteworthy observation of myocardial hypoattenuation, in correspondence with the multimodality cardiovascular imaging findings, suggests that standard contrast-enhanced CT may provide information regarding tissue characterization. This report also demonstrates the independent clinical utility of CMR and PET in the evaluation and management of cardiac sarcoidosis. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.018DOI Listing

Pulmonary rehabilitation and daily life physical activity in patients with stage IV sarcoidosis.

Respir Med Res 2020 Jun 13;78:100775. Epub 2020 Jun 13.

FormactionSanté, 59840 Pérenchies, France.

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http://dx.doi.org/10.1016/j.resmer.2020.100775DOI Listing

Spondyloarthritis and sarcoidosis: related or fake friends? A systematic literature review.

Joint Bone Spine 2020 Jul 1. Epub 2020 Jul 1.

Department of Rheumatology, Rennes University Hospital, 35000, Rennes, France; CHU Rennes, Univ Rennes, INSERM, Institut NUMECAN (Nutrition Metabolisms and Cancer), F-35000, Rennes, France. UMR INSERM U 1241, University of Rennes 1, 35000, Rennes, France.

Background: Sarcoidosis and spondyloarthritis (SpA) have been regularly associated. Bone iliac granulomas have also been described. We propose herein a systematic review of rheumatologic axial manifestations of sarcoidosis. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.06.011DOI Listing

Blau syndrome: NOD2-related systemic autoinflammatory granulomatosis.

G Ital Dermatol Venereol 2020 Jul 2. Epub 2020 Jul 2.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan -

Blau syndrome, or early-onset sarcoidosis, is hereditary juvenile-onset systemic granulomatosis. Clinical symptoms appear before the age of 4 years and mainly affect the skin, joints, and eyes. The symptoms are progressive and cause severe complications, such as joint destruction and blindness. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06524-6DOI Listing

Diffuse Sarcoidosis Masquerading as Widespread Malignant Disease: A Rare Case Report and Literature Review.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620938942

James H. Quillen Veterans Affairs Medical Center, Mountain Home, TN, USA.

Sarcoidosis is a multisystem granulomatous disease commonly involving the lungs and mediastinal lymph nodes with the exact etiology being unclear. The simultaneous presence of malignant disease such as breast cancer and sarcoidosis has been reported. Sarcoidosis preceding a diagnosis of malignancy and that occurring years after treatment of malignant disease has been noted in the past. Read More

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http://dx.doi.org/10.1177/2324709620938942DOI Listing

Solid Pseudopapillary Tumor of the Pancreas in a Patient With Sarcoidosis: A Rare Combination.

Cureus 2020 May 28;12(5):e8340. Epub 2020 May 28.

Gastroenterology, Creighton University School of Medicine, St. Joseph's Hospital and Medical Center, Phoenix, USA.

Sarcoidosis is a chronic granulomatous disease that is characterized by the formation of non-caseating granulomas, predominantly involving the lung and lymph nodes. Over the years, sarcoidosis has been associated with a high risk of malignancy. Solid pseudopapillary tumor of the pancreas is an uncommon pancreatic tumor with a 15% malignant potential. Read More

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http://dx.doi.org/10.7759/cureus.8340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325336PMC

Sarcoidosis presenting as hiccups.

Respirol Case Rep 2020 Aug 29;8(6):e00605. Epub 2020 Jun 29.

Division of Pulmonary Medicine Memorial Sloan Kettering Cancer Center New York NY USA.

Hiccups are common; however, hiccups caused by sarcoidosis have rarely been reported. An unusual case involving a patient with persistent hiccups possibly caused by hilar/mediastinal lymph node enlargement due to sarcoidosis prompted us to perform a literature search. Eight case reports relating hiccups to sarcoidosis were found and in only one case were the hiccups thought to be due to thoracic lymphadenopathy (LAD). Read More

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http://dx.doi.org/10.1002/rcr2.605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324693PMC

Measurement of angiotensin-I-converting enzyme in the blood: help for method validation.

Ann Biol Clin (Paris) 2020 Jul 2. Epub 2020 Jul 2.

Service de biochimie, Hôpital Robert Debré, AP-HP-Nord-Université de Paris, France.

Blood angiotensin-converting enzyme (ACE) assay is now realized by the determination of enzyme activity on synthetic substrate, mostly furylacryloyl-phenylalanyl-L-glycyl-L-glycine (FAPGG). The matrix can be serum or heparin-plasma, with or without a separator; the assay developed on serum or plasma is not adapted to other matrix such as cerebrospinal fluid where the ACE activity is much lower. This assay has been adapted on a number of automated biochemistry analyzers with the specifications of the supplier of reagents, sometimes with modification of volumes or times for analysis. Read More

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http://dx.doi.org/10.1684/abc.2020.1568DOI Listing

Ulcerative necrobiosis lipoidica with granulomatous vasculitis mimicking sclerosing panniculitis in a patient with sarcoidosis.

Int J Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

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http://dx.doi.org/10.1111/ijd.15033DOI Listing

Krebs von den Lungen-6 as biomarker for disease severity assessment in interstitial lung disease: a comprehensive review.

Biomark Med 2020 Jul 2. Epub 2020 Jul 2.

Respiratory Diseases & Lung Transplantation, Department of Medical & Surgical Sciences & Neurosciences, Siena University Hospital, Siena, Italy.

Interstitial lung diseases (ILD) are a group of lung disorders characterized by interstitial lung thickening. Krebs von den Lungen-6 (KL-6) is a molecule that is predominantly expressed by damaged alveolar type II cells and it has been proposed as a potential biomarker of different ILD. A growing literature about KL-6 has been reviewed and selected to evaluate its role in the clinical management of ILD to predict disease diagnosis, activity, prognosis and treatment response. Read More

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http://dx.doi.org/10.2217/bmm-2019-0545DOI Listing

Chest X-ray and Uveitis Evaluation in a Population with Low Incidence of Sarcoidosis.

Ophthalmol Ther 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.

Introduction: Radiographic chest imaging is utilized in the workup of uveitis, with the purpose of diagnosing sarcoidosis. Sarcoidosis is an idiopathic systemic granulomatous inflammation which accounts for approximately 10% of uveitis. The prevalence of sarcoidosis and uveitis varies widely with geography and ethnicity. Read More

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http://dx.doi.org/10.1007/s40123-020-00274-6DOI Listing

Reproducibility of cardiac magnetic resonance imaging in patients referred for the assessment of cardiac sarcoidosis; implications for clinical practice.

Int J Cardiovasc Imaging 2020 Jul 1. Epub 2020 Jul 1.

Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.

Cardiac sarcoidosis (CS) is an increasingly recognized condition, but cardiac magnetic resonance (CMR) image interpretation in these patients may be challenging as findings are often non-specific. The main objective of this study was to investigate the inter-reader agreement for the overall interpretation of CMR for the diagnosis of CS in an experienced reference center and investigate factors that may lead to discrepancies between readers. Consecutive patients undergoing CMR imaging to investigate for CS were included. Read More

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http://dx.doi.org/10.1007/s10554-020-01923-4DOI Listing

Concurrent primary Sjögren's syndrome and isolated ocular sarcoidosis presenting with bilateral corneal scarring and dry eye.

Am J Ophthalmol Case Rep 2020 Sep 17;19:100790. Epub 2020 Jun 17.

The Wilmer Eye Institute, The Johns Hopkins University Medical School, Baltimore, MD, USA.

Purpose: To report the case of a patient who presents with multiple progressive ocular diseases who is diagnosed with concurrent primary Sjögren's syndrome and isolated ocular sarcoidosis.

Observation: A 60-year-old woman was referred for dry eye disease, bilateral interstitial keratitis, anterior uveitis, and progressive glaucoma. There was clinical suspicion of an autoimmune etiology due to her ocular history, risk factors, and presentation. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320313PMC
September 2020

Autoimmune Pulmonary Alveolar Proteinosis Complicated with Sarcoidosis: The Clinical Course and Serum Levels of Anti-granulocyte-macrophage colony-stimulating Factor Autoantibody.

Intern Med 2020 Jun 30. Epub 2020 Jun 30.

Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.

Autoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction due to anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody. We experienced 2 cases of APAP complicated with sarcoidosis in a 42-year-old woman and a 51-year-old man (age at the sarcoidosis diagnosis). APAP preceded sarcoidosis in the woman, and both diseases were diagnosed simultaneously in the man. Read More

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http://dx.doi.org/10.2169/internalmedicine.3853-19DOI Listing

COVID-19 in Patient with Sarcoidosis Receiving Long-Term Hydroxychloroquine Treatment, France, 2020.

Emerg Infect Dis 2020 Jul 1;26(10). Epub 2020 Jul 1.

Because of in vitro studies, hydroxychloroquine is under evaluation as a preexposure or postexposure prophylaxis for coronavirus disease (COVID-19) and as a possible COVID-19 curative treatment. We report a case of COVID-19 in a patient with sarcoidosis who was receiving long-term hydroxychloroquine treatment, despite adequate plasma concentrations. Read More

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http://dx.doi.org/10.3201/eid2610.201816DOI Listing

Teaching Neuroimages: Rare skull base involvement in neurosarcoidosis.

Neurology 2020 Jun 30. Epub 2020 Jun 30.

Department of Neurology, The Royal London Hospital, London, UK

A 57-year-old woman was admitted with a tonic-clonic seizure on a background of systemic sarcoidosis with uveitis and hilar lymphadenopathy. She had previously been well and stopped steroids one year before presentation. CT showed a sclerotic lesion with focal lucent areas in the skull base MRI revealed a frontal FLAIR hyperintense oedematous lesion with meningeal enhancement in gadolinium T1 This appearance on imaging evokes broad differential diagnoses such as sarcoidosis, fungal (although she had increasing lesion size despite six-month treatment with amphotericin B), craniofacial fibrous dysplasia, atypical lymphoma, nasopharyngeal carcinoma, myeloma and tuberculosis, therefore necessitating biopsy for definitive evaluation. Read More

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http://dx.doi.org/10.1212/WNL.0000000000010082DOI Listing

Response to: 'Glucocorticoid-induced relapse of COVID-19 in a patient with sarcoidosis' by Györfi .

Ann Rheum Dis 2020 Jun 30. Epub 2020 Jun 30.

Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia

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http://dx.doi.org/10.1136/annrheumdis-2020-218328DOI Listing

Glucocorticoid-induced relapse of COVID-19 in a patient with sarcoidosis.

Ann Rheum Dis 2020 Jun 30. Epub 2020 Jun 30.

Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Bayern, Germany

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http://dx.doi.org/10.1136/annrheumdis-2020-218258DOI Listing

Sarcoidosis with Hepatic Involvement: A Case Report.

Sisli Etfal Hastan Tip Bul 2018 30;52(1):54-56. Epub 2018 Mar 30.

Department of Gastroenterology, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.

Sarcoidosis is a systemic, noncaseating granulomatous disease with an unknown etiology. The liver is one of the most frequently affected organs. This case is presented to emphasize that hepatic granulomatous foci can lead to a determination of etiology in a diagnosis of sarcoidosis. Read More

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http://dx.doi.org/10.14744/SEMB.2017.76598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315081PMC

68Ga-DOTATOC PET for Treatment Efficacy Evaluation of Cardiac Sarcoidosis.

Clin Nucl Med 2020 Jun 25. Epub 2020 Jun 25.

From the Nuclear Medicine and Molecular Imaging, ICANS-University Hospitals of Strasbourg.

Cardiac sarcoidosis (CS) has a poor prognosis related to life-threating arrhythmias and heart failure. Treatment includes anti-inflammatory therapies and implantable pacemaker and/or cardioverter defibrillator. The presence of cardiac devices and physiologic myocardial glucose uptake are major limitations of both cardiac magnetic resonance and F-FDG PET/CT, reducing their diagnostic value. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003185DOI Listing

Hepatic Sarcoidosis Presenting as Hypercalcemia, a Case Report.

Am J Med 2020 Jun 27. Epub 2020 Jun 27.

Department of Pathology, University of Arizona, Banner University Medical Center Tucson Campus, Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1016/j.amjmed.2020.05.031DOI Listing

Corrigendum to "The utility of serum C-C chemokine ligand 1 in sarcoidosis: A comparison to IgG4-related disease" [Cytokine 133 (2020) 155123].

Cytokine 2020 Jun 26:155171. Epub 2020 Jun 26.

First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2020.155171DOI Listing

Immunopathogenesis and therapeutic potential of macrophage influx in diffuse parenchymal lung diseases.

Expert Rev Respir Med 2020 Jun 30:1-12. Epub 2020 Jun 30.

Department of Pulmonary Medicine, V.P.Chest Institute , New Delhi, India.

Introduction: The diffuse parenchymal lung diseases (DPLD)/interstitial lung diseases (ILD) are progressive lung disorders with usually unclear etiology, poor long-term survival and no effective treatment. Their pathogenesis is characterized by alveolar epithelial cell injury, inflammation, epithelial-mesenchymal transition, and parenchymal fibrosis. Macrophages play diverse roles in their development, both in the acute phase and in tissue repair. Read More

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http://dx.doi.org/10.1080/17476348.2020.1776117DOI Listing

Whole-exome sequencing in three children with sporadic Blau syndrome, one of them co-presenting with recurrent polyserositis.

Autoimmunity 2020 Jun 29:1-9. Epub 2020 Jun 29.

División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social.

Blau syndrome (BS) is a rare, chronic autoinflammatory disease with onset before age 4 and mainly characterised by granulomatous arthritis, recurrent uveitis, and skin rash. Sporadic (also known as early-onset sarcoidosis) or familial BS is caused by gain-of-function mutations in the gene, which encodes for a multi-task protein that plays a crucial role in the innate immune defense. We report on three Mexican patients clinically diagnosed with BS who exhibited a likely pathogenic variant in as revealed by whole-exome sequencing (WES) and Sanger sequencing: two variants (c. Read More

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http://dx.doi.org/10.1080/08916934.2020.1786068DOI Listing

Bilateral swelling of the forearms revealing muscular sarcoidosis: a case-based review.

Clin Rheumatol 2020 Jun 27. Epub 2020 Jun 27.

Rheumatology Department, Mohammed V University, Rabat, Morocco.

Muscular sarcoidosis is rarely symptomatic and mainly affects proximal muscles of the lower extremities. However, the distal localization in the upper extremities is rare. We used systematic approach to analyze all relevant literature review and we identified only three cases of muscular sarcoidosis of the upper extremities. Read More

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http://dx.doi.org/10.1007/s10067-020-05259-1DOI Listing

Cutaneous Sarcoidosis.

Semin Respir Crit Care Med 2020 Jun 27. Epub 2020 Jun 27.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Sarcoidosis is a chronic, multisystem, inflammatory disorder of unknown etiology that is characterized by noncaseating granulomas that impair normal organ functioning. Sarcoidosis predominantly affects the lungs, but the skin is often cited as the second most frequently involved organ. Cutaneous manifestations of sarcoidosis are highly variable and ongoing research seeks to better understand the relationship between clinical morphology and disease prognosis. Read More

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http://dx.doi.org/10.1055/s-0040-1713130DOI Listing

Cardiac Sarcoidosis.

Authors:
David H Birnie

Semin Respir Crit Care Med 2020 Jun 27. Epub 2020 Jun 27.

Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Approximately 5% of patients with sarcoidosis will have cardiac involvement presenting with one or more of ventricular arrhythmias, conduction abnormalities, and heart failure. It is estimated that another 20 to 25% of pulmonary/systemic sarcoidosis patients have asymptomatic cardiac involvement ( disease). Cardiac presentations can be the first (and/or an unrecognized) manifestation of sarcoidosis in a variety of circumstances. Read More

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http://dx.doi.org/10.1055/s-0040-1712535DOI Listing

Comparison of conventional immunosuppressive drugs versus anti-TNF-α agents in non-infectious non-anterior uveitis.

J Autoimmun 2020 Jun 22:102481. Epub 2020 Jun 22.

Ophthalmology Department, Hospital Charles Nicolle, Rouen, France; EA7510, UFR Santé, Rouen University, Rouen, France.

Objective: To compare the efficacy and safety of Disease-modifying antirheumatic drugs (DMARDs) and anti-TNF-α agents in patients with non-infectious non-anterior uveitis.

Methods: Single center retrospective study including adult patients with non-infectious intermediate, posterior or pan-uveitis. Outcomes were compared between patients treated with DMARDs or anti-TNF-α agents. Read More

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http://dx.doi.org/10.1016/j.jaut.2020.102481DOI Listing

Hypertrophic cardiomyopathy masquerading as sarcoidosis: cases illustrating cardiac imaging overlap relative to pathology.

Cardiovasc Pathol 2020 May 19;49:107234. Epub 2020 May 19.

Centre for Heart Lung Innovation, St Paul's Hospital/University of British Columbia, Vancouver, BC, Canada; Departments of Pathology and Laboratory Medicine, Providence Health Care/University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.carpath.2020.107234DOI Listing

Evaluation of Subclinical Atherosclerosis with Carotid Intima-Media and Epicardial Fat Thickness in Patients with Sarcoidosis.

Turk Thorac J 2020 May;21(3):174-179

Department of Pulmonary Medicine, Baskent University School of Medicine, Ankara, Turkey.

Objectives: Since many similar mechanisms may play a role in the pathophysiology of sarcoidosis and atherosclerosis, the risk of subclinical atherosclerosis may be increased in patients with sarcoidosis. The aim of this study was to evaluate known markers of subclinical atherosclerosis, namely epicardial fat thickness (EFT) and carotid intima-media thickness (CIMT) in patients with sarcoidosis.

Materials And Methods: This cross-sectional study included a total of 183 subjects, including 94 patients with sarcoidosis (patient group) and a control group of 89 healthy individuals. Read More

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http://dx.doi.org/10.5152/TurkThoracJ.2019.19017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311145PMC

Evaluation of Serum Biomarkers in Patients with Sarcoidosis: Can Visfatin Be a New Biomarker for Sarcoidosis?

Turk Thorac J 2020 May;21(3):145-149

Department of Biochemical, Bağcılar Education and Research Hospital, İstanbul, Turkey.

Objectives: Sarcoidosis is a chronic systemic inflammatory disease that affects multiple organ systems. The role of biomarkers in the diagnosis and prognosis of sarcoidosis is increasing. Interest in the role of adipose tissue-mediated inflammation in the pathogenesis of inflammatory diseases has increased in recent years. Read More

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http://dx.doi.org/10.5152/TurkThoracJ.2019.180112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311147PMC

Health-Related Quality of Life in Sarcoidosis.

Authors:
Ogugua Ndili Obi

Semin Respir Crit Care Med 2020 Jun 24. Epub 2020 Jun 24.

Division of Pulmonary, Critical Care and Sleep Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina.

Health-related quality of life (HRQoL) describes an individual's perception of the impact of health, disease, and treatment on their quality of life (QoL). It is a reflection of how the manifestation of an illness and its treatment is personally experienced. Assessing HRQoL is particularly important in sarcoidosis because the attributable disease mortality is relatively low, and one of the major reasons for initiating treatment is to improve quality of life. Read More

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http://dx.doi.org/10.1055/s-0040-1710080DOI Listing

Prosthetic Rehabilitation of a Patient Diagnosed With Sarcoidosis Using Dental Implants: A Clinical Case Report.

J Oral Implantol 2020 Jun;46(3):235-243

Royal London Dental Hospital, Bart's Health NHS Trust, London, United Kingdom.

No previously published studies have reported on the placement and restoration of dental implants in a patient diagnosed with sarcoidosis. Patients with sarcoidosis may develop periodontitis as a manifestation of systemic disease and are therefore at increased risk of tooth loss. These patients are likely to want fixed dental prostheses, which may need to be supported by dental implants. Read More

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http://dx.doi.org/10.1563/aaid-joi-D-18-00309DOI Listing

A Case Report of Rapidly Lethal Acute Respiratory Distress Syndrome Secondary to Coronavirus Disease 2019 Viral Pneumonia.

Cureus 2020 May 21;12(5):e8228. Epub 2020 May 21.

Anesthesiology, State University of New York Downstate Medical Center, Brooklyn, USA.

As of April 2020, the coronavirus 2019 (COVID-19) pandemic has resulted in more than 210,000 deaths globally. The most common cause of death from COVID-19 is acute respiratory failure. We report the case of a 78-year-old female with a history of hypertension, cerebrovascular accident (CVA), type 2 diabetes mellitus, and sarcoidosis, who presented to the emergency department with one day of dyspnea. Read More

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http://dx.doi.org/10.7759/cureus.8228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306658PMC

Diagnosis of isolated cardiac sarcoidosis based on new guidelines.

ESC Heart Fail 2020 Jun 24. Epub 2020 Jun 24.

Department of Cardiology, Fujita Health University, 1-98 Dengakugakubo, Toyoake, Japan.

Aims: In the updated guidelines for cardiac sarcoidosis (CS) proposed by the Japanese Circulation Society (JCS), the definition of isolated CS (iCS) was established for the first time. This prompted us to examine the characteristics of patients with CS including iCS according to them by reviewing patients undergoing F-fluoro-2-deoxyglucose positron-emission tomography/computerized tomography (FDG-PET/CT), compared with those with CS determined by the conventional international criteria.

Methods And Results: From 2013 to 2019, 94 patients (61 ± 15 years, 50 female patients) with suspected CS underwent whole-body and cardiac FDG-PET/CT scanning. Read More

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http://dx.doi.org/10.1002/ehf2.12853DOI Listing

A Rare Case of Sarcoidosis-Induced Polyserositis and Steroid-Induced Mediastinal Lipomatosis Masquerading as an Epicardial Tumor.

CASE (Phila) 2020 Jun 13;4(3):166-169. Epub 2020 Feb 13.

Leon H. Charney Division of Cardiology, New York University Langone Medical Center, New York, New York.

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http://dx.doi.org/10.1016/j.case.2020.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303243PMC

Cavernous sinus lesions.

Clin Imaging 2020 Jun 18;68:71-89. Epub 2020 Jun 18.

NYU Langone Health, Department of Radiology, New York, NY, United States of America. Electronic address:

The cavernous sinus is a complex structure susceptible to a wide variety of vascular, neoplastic and inflammatory pathologies. Vascular pathologies include ICA aneurysms, carotid-cavernous fistulas, cavernous sinus thrombosis, and cavernous hemangioma. Neoplasms that involve the cavernous sinus include pituitary adenoma, meningioma, schwannoma, lymphoma, perineural tumor spread, metastases, and direct tumor invasion. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.029DOI Listing

Causes of Erythema Nodosum in Patients Admitted to a Tertiary Care Hospital in Spain.

Actas Dermosifiliogr 2020 Jun 20. Epub 2020 Jun 20.

Servicio de Oncología Radioterápica. Hospital Universitario 12 de Octubre, Madrid, España.

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http://dx.doi.org/10.1016/j.ad.2018.12.012DOI Listing

Maraviroc, a future treatment of sarcoidosis? An unexpected drug effect.

J Investig Allergol Clin Immunol 2020 Jun 23. Epub 2020 Jun 23.

Infectious Diseases Department, Nancy University Hospital, Nancy, France.

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http://dx.doi.org/10.18176/jiaci.0537DOI Listing

Management of Sarcoidosis-Associated Pulmonary Hypertension.

Clin Med Res 2020 Jun 22. Epub 2020 Jun 22.

Pulmonary and Critical Care Medicine Section, Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.3121/cmr.2020.1556DOI Listing

A case of a tattoo granuloma with uveitis (TAGU) without sarcoidosis.

Am J Emerg Med 2020 Jun 2. Epub 2020 Jun 2.

Department of Emergency Medicine, Cleveland Clinic, Cleveland, OH, United States of America.

Tattooing is associated with a handful of potential complications. Short-term complications such as pain, pruritus, erythema, or swelling at the tattoo-site commonly occur from local skin trauma. Long-term complications tend to involve infections or immune-mediated reactions such as sarcoidosis. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.05.106DOI Listing

Sarcoidosis with cryptococcal infection apparently engaging only immune-privileged body compartments: a case report.

BMC Infect Dis 2020 Jun 22;20(1):440. Epub 2020 Jun 22.

Medical Microbiology, Innlandet Hospital Trust, Lillehammer, Norway.

Background: Infection with the Cryptococcus neoformans yeast fungus is largely restricted to patients with HIV, sarcoidosis or immunosuppressive therapies. In sarcoidosis, there is intense local immune response in granuloma lesions, coupled with a paradoxical systemic anergy. An analysis of cryptococcal infection in sarcoidosis may therefore shed light on whether opportunistic pathogens preferentially engage immune-privileged tissues. Read More

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http://dx.doi.org/10.1186/s12879-020-05174-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310135PMC

Relevance of concurrent hypercalcemia in ureteric sarcoidosis complicated with bladder urothelial carcinoma: a case report.

BMC Nephrol 2020 Jun 22;21(1):235. Epub 2020 Jun 22.

Department of Urology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-0001, Japan.

Background: Sarcoidosis is a multisystem inflammatory disorder and can affect any organ; however, ureteric involvement is extremely rare with only four cases reported in the literature to date, all of which were diagnosed with surgical ureteral resection including a nephroureterectomy. This study reports the first case of ureteric sarcoidosis controlled with medical therapy where a differential diagnosis was performed based on the diagnostic clue of hypercalcemia. A definitive diagnosis was established without surgical resection of the ureter. Read More

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http://dx.doi.org/10.1186/s12882-020-01893-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310021PMC

SARCOIDOSIS DIAGNOSED IN THE ELDERLY: A CASE CONTROL STUDY.

QJM 2020 Jun 22. Epub 2020 Jun 22.

Department of Internal Medicine, University Hospital Lyon Croix-Rousse, Claude Bernard University - Lyon 1, Lyon, France.

Background: Studies on sarcoidosis in elderly patients are scarce and none have specifically evaluated patients aged ≥75 at onset.

Aim: We aimed to analyze the characteristics of patients with sarcoidosis diagnosed after 75 and to compare them with those of younger patients.

Design: Multicenter case control study comparing elderly-onset sarcoidosis (EOS) with young-onset sarcoidosis (YOS) seen at Lyon University Hospitals between 2006 and 2018. Read More

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http://dx.doi.org/10.1093/qjmed/hcaa171DOI Listing

The extended utility of antifibrotic therapy in progressive fibrosing interstitial lung disease.

Expert Rev Respir Med 2020 Jun 22. Epub 2020 Jun 22.

Manchester University NHS Foundation Trust , Manchester, United Kingdom.

Introduction: The approval of two antifibrotic treatment agents for delaying disease progression in idiopathic pulmonary fibrosis (IPF), has prompted researchers to look at expanding the role of antifibrotic therapy to other fibrosing interstitial lung disease (ILD). Similarities in the pathological mechanisms that lead to the development of IPF have been implicated in other progressive fibrosing ILD (PF-ILD) such as chronic hypersensitivity pneumonitis, connective tissues disease associated ILD, sarcoidosis, occupational ILD and idiopathic non-specific interstitial pneumonia (iNSIP). This has prompted the rationale to use antifibrotic therapy to target similar molecular pathways in these diseases. Read More

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http://dx.doi.org/10.1080/17476348.2020.1784730DOI Listing

Neurosarcoidosis: Analysis of a series of 20 patients.

Med Clin (Barc) 2020 Jun 18. Epub 2020 Jun 18.

Servicio de Neurología, Hospital Virgen de la Victoria, Málaga, España. Electronic address:

Introduction: Neurosarcoidosis is a rare complication of sarcoidosis. There are small series on the condition and very few from Spain. We conducted a retrospective study of neurosarcoidosis in Virgen de la Victoria Hospital over the last 10 years. Read More

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http://dx.doi.org/10.1016/j.medcli.2020.04.027DOI Listing

Massive pericardial effusion causing cardiac tamponade accompanied by elevated CA-125 and thoracic lymphadenopathy in sarcoidosis: a case report.

Int J Surg Case Rep 2020 Jun 13;72:355-360. Epub 2020 Jun 13.

Scientific Research Institute of Heart Surgery and Organ Transplantation, Bishkek, Kyrgyzstan.

Introduction: Pericardial effusion and cardiac tamponade are rare manifestations of cardiac sarcoidosis. This is a first case report that describes a patient with severe pericardial effusion and signs of cardiac tamponade with elevated carbohydrate antigen 125 (CA-125) levels, enlarged pericardial (PLN) and mediastinal lymph nodes (MLN), histologically confirmed as sarcoidosis.

Presentation Of Case: A 51-year-old female patient was admitted with complaints of sickness, shortness of breath on minimal exertion, swelling in lower extremities, and heaviness in right upper abdomen. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306529PMC

Identification of Specific Endobronchial Ultrasound Features to Differentiate Sarcoidosis From Other Causes of Lymphadenopathy.

J Ultrasound Med 2020 Jun 20. Epub 2020 Jun 20.

Department of Life Science, National Chung Hsing University, Taichung, Taiwan.

Objectives: We hypothesized that specific endobronchial ultrasound (EBUS) features may differentiate sarcoidosis from other causes of lymphadenopathy.

Methods: We conducted this retrospective observational study from January 2014 to January 2019 to analyze patients with intrathoracic lymphadenopathy who underwent EBUS-guided transbronchial needle aspiration. Ultrasound features, including nodal size, margin, echogenicity, the presence or absence of calcification, a central hilar structure, the coagulation necrosis sign, nodal conglomeration, and the septal vessel sign in the color Doppler mode were recorded and compared between 3 groups. Read More

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http://dx.doi.org/10.1002/jum.15372DOI Listing