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    Characteristics of Sarcoidosis in Patients with Previous Malignancy: Causality or Coincidence?
    Respiration 2017 Feb 24. Epub 2017 Feb 24.
    Institute of Pulmonary Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
    Background: The association between sarcoidosis and malignancy is poorly defined. Sarcoidosis can precede, be diagnosed concurrently with, or follow malignancy.

    Objectives: We describe the clinical and radiological features of patients with sarcoidosis following malignancy to determine whether this association is causal or coincidental. Read More

    Biomarkers in Autoimmune Salivary Gland Disorders: A Review.
    ORL J Otorhinolaryngol Relat Spec 2017 Feb 24;79(1-2):43-53. Epub 2017 Feb 24.
    Otorhinolaryngology/Head and Neck Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
    Salivary glands are frequent sites of manifestations of autoimmune disorders in the head and neck. Sjögren syndrome, sarcoidosis, granulomatosis with polyangiitis, and IgG4-related sialadenitis represent the most important autoimmune salivary gland disorders. Due to the lack of specific symptoms, diagnosis of these conditions remains a challenge. Read More

    Classification of idiopathic interstitial pneumonias using anti-myxovirus resistance-protein 1 autoantibody.
    Sci Rep 2017 Feb 23;7:43201. Epub 2017 Feb 23.
    Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita City, Osaka 565-0871, Japan.
    Chronic fibrosing idiopathic interstitial pneumonia (IIP) can be divided into two main types: idiopathic pulmonary fibrosis (IPF), a steroid-resistant and progressive disease with a median survival of 2-3 years, and idiopathic non-specific interstitial pneumonia (INSIP), a steroid-sensitive and non-progressive autoimmune disease. Although the clinical courses of these two diseases differ, they may be difficult to distinguish at diagnosis. We performed a comprehensive analysis of serum autoantibodies from patients definitively diagnosed with IPF, INSIP, autoimmune pulmonary alveolar proteinosis, and sarcoidosis. Read More

    Comprehensive evaluation of airway involvement in pulmonary sarcoidosis.
    ERJ Open Res 2017 Jan 14;3(1). Epub 2017 Feb 14.
    Dept of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    IOS can predict airway hyperresponsiveness and long-term outcome in patients with pulmonary sarcoidosis http://ow.ly/bkQH307VD4m. Read More

    Malabsorption syndrome as a rare cause of nephrocalcinosis.
    Clin Cases Miner Bone Metab 2016 Sep-Dec;13(3):247-248. Epub 2017 Feb 10.
    Department of Nephrology, Centro Hospitalar Trás-os-Montes e Alto Douro, Vila Real, Portugal.
    Nephrocalcinosis is characterized by calcification of kidney parenchyma and can be caused by an increased amount of calcium, phosphate or oxalate in urinary excretion. We report a 35-year-old female with nephrocalcinosis. She had fitful steatorrhea since last year. Read More

    Tumor Necrosis Factor Alpha Blocker-Induced Erythrodermic Sarcoidosis in with Juvenile Rheumatoid Arthritis: A Case Report and Review of the Literature.
    Ann Dermatol 2017 Feb 3;29(1):74-78. Epub 2017 Feb 3.
    Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea.; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
    The development of cutaneous sarcoidosis as a paradoxical adverse event of tumor necrosis factor alpha (TNF-α) blockers has been reported in the literature; however, an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy has not yet been reported. Herein, we report the first case of an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy and review previous studies of cutaneous sarcoidosis. A 6-year-old Korean girl who had been suffering from juvenile rheumatoid arthritis presented with generalized erythematous skin eruption involving more than about 90% of her body surface area. Read More

    Conjunctival deposits as the first sign of systemic sarcoidosis in a pediatric patient.
    Eur J Ophthalmol 2006 Jan - Feb;16(1):160-162
    Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakiyr - Turkey.
    Purpose: Sarcoidosis is an inflammatory disease of unknown cause, characterized by noncaseating granulomas. In this study, the authors present a sarcoidosis patient without systemic signs diagnosed by histopathologic analysis of conjunctival deposits.

    Methods: A 10-year-old girl had bilateral, focal, multilobular, multiple pale yellow deposits in bulbar conjunctiva for a year. Read More

    The endosonography-guided needle aspiration in the diagnosis of sarcoidosis - randomized study.
    Pol Arch Med Wewn 2017 Feb 9. Epub 2017 Feb 9.
    INTRODUCTION    There are no widely accepted standards of diagnosis of sarcoidosis.  OBJECTIVES    The aim of the study was to assess the relative diagnostic yield of endobronchial ultrasound needle aspiration (EBUS-NA) and endoscopic ultrasound needle aspiration (EUS-NA), and to compare them with the standard diagnostic techniques, i.e. Read More

    Corticosteroid and Azithromycin in Idiopathic Granulomatous Mastitis.
    Adv Biomed Res 2017 31;6. Epub 2017 Jan 31.
    Dentistry School, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Mastitis is an inflammatory disorder in breast tissues due to bacterial factors, mycobacterial infections or autoimmune diseases. Idiopathic granulomatous mastitis (IGM) is a form of mastitis which may be affected by systematic diseases such as sarcoidosis, and infectious causes such as mycobacterium and fungus. This study evaluates the efficacy of medical therapy with a combination of corticosteroid and Azithromycin in patients with IGM. Read More

    Bidirectional ventricular tachycardia in cardiac sarcoidosis.
    J Arrhythm 2017 Feb 4;33(1):69-72. Epub 2016 Jun 4.
    Department of Internal Medicine (Division of Cardiology), University of Wisconsin Hospital and Clinics, 600 Highland Ave, Madison, WI 53713, United States.
    A 73-year-old man with history of pulmonary sarcoidosis was found to have runs of non-sustained bidirectional ventricular tachycardia (BVT) with two different QRS morphologies on a Holter monitor. Cardiac magnetic resonance delayed gadolinium imaging revealed a region of patchy mid-myocardial enhancement within the left ventricular basal inferolateral myocardium. An 18-fluorodeoxyglucose positron emission tomography (FDG-PET) showed increased uptake in the same area, consistent with active sarcoid, with no septal involvement. Read More

    Cardiac sarcoidosis - diagnostic challenges due to unusual clinical presentation.
    Hellenic J Cardiol 2017 Feb 16. Epub 2017 Feb 16.
    Vilnius University, Clinic of Cardiovascular Diseases, Centre of Cardiology and Angiology, Vilnius, Lithuania.

    [Headaches in autoimmune diseases].
    Wiad Lek 2016 ;69(6):773-777
    Uniwersytet Medyczny w Lublinie, Polska.
    Vasculitides in autoimmune diseases are an important cause of secondary headaches. The article discusses the incidence of headache in primary and secondary vasculitides of the central nervous system. The symptoms of primary CNS vasculitis are presented. Read More

    A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient.
    Australas J Dermatol 2017 Feb 17. Epub 2017 Feb 17.
    Australian National University Medical School, Canberra, Australian Capital Territory, Australia.
    Necrobiosis lipoidica (NL) and cutaneous sarcoidosis are granulomatous disorders with a largely unknown aetiopathogenesis. Evidence of co-existing NL and sarcoidosis in the same patient may suggest a degree of overlap between these entities through shared granulomatous inflammatory pathways. Occasionally, one condition can mimic the other, making their distinction difficult. Read More

    Risk of fragility fracture among patients with sarcoidosis: a population-based study 1976-2013.
    Osteoporos Int 2017 Feb 16. Epub 2017 Feb 16.
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, 200 First Avenue SW, Rochester, MN, 55905, USA.
    Incidence of fragility fracture of a population-based cohort of 345 patients with sarcoidosis was compared with age and sex-matched comparators. The incidence of fragility fracture was higher among patients with sarcoidosis with hazard ratio (HR) of 2.18. Read More

    Sarcoidosis Extent Relates to Molecular Variability.
    Clin Exp Immunol 2017 Feb 16. Epub 2017 Feb 16.
    Janssen Research & Development, LLC, Spring House, PA.
    The molecular basis of sarcoidosis phenotype heterogeneity and its relationship to effective treatment of sarcoidosis have not been elucidated. Peripheral samples from sarcoidosis subjects who participated in a phase 2 study of golimumab (anti-TNFα) and ustekinumab (anti-IL12p40) were used to measure the whole blood transcriptome and levels of serum proteins. Differential gene and protein expression analyses were used to explore the molecular differences between sarcoidosis phenotypes as defined by extent of organ involvement. Read More

    Cyanoacrylate Associated Foreign Body Granulomatous Gastritis: A Report of Three Cases.
    Case Rep Pathol 2017 19;2017:2753487. Epub 2017 Jan 19.
    Department of Pathology, Faculty of Medicine, Hacettepe University, Sıhhiye, 06100 Ankara, Turkey.
    Granulomas are rarely seen in gastric biopsies mostly as an involvement of granulomatous diseases like sarcoidosis, Crohn's disease, infections, neoplasms, and vasculitis. Here, we claim cyanoacrylate as a foreign body type granuloma-causing agent in the stomach after vascular embolisation. We present cyanoacrylate associated gastric changes of three cases: two endoscopic biopsies and one gastric resection. Read More

    Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis.
    J Thorac Dis 2017 Jan;9(1):88-95
    Clinic of Infectious, Chest diseases, Dermatovenereology and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania;; Center of Pulmonology and Allergology, Vilnius University Hospital Santariskiu klinikos, Vilnius, Lithuania.
    Background: The aim of the present study was to identify specious radiologic and/or physiologic prognostic marker(s), which lead to optimize of the patient follow-up frequency.

    Methods: Eighty consecutive patients with newly diagnosed pulmonary sarcoidosis. Patients underwent chest radiography, high-resolution computed tomography (HRCT) examination, pulmonary function tests (PFT), bronchoscopy with bronchoalveolar lavage (BAL) and lung biopsy, and bronchoalveolar lavage fluid (BALF) cell examination. Read More

    Upregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosis.
    BMC Pulm Med 2017 Feb 15;17(1):39. Epub 2017 Feb 15.
    Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School, Bucheon, Korea.
    Background: Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood.

    Methods: TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal controls (NCs; n = 40) and from patients with idiopathic pulmonary fibrosis (IPF; n = 100), non-specific interstitial pneumonia (NSIP; n = 22), hypersensitivity pneumonitis (HP; n = 20), and sarcoidosis (n = 19).

    Results: The TSLP and IL-33 levels were significantly higher in patients with IPF relative to the NCs (p = 0. Read More

    Personalized medicine in interstitial lung diseases.
    Curr Opin Pulm Med 2017 Feb 13. Epub 2017 Feb 13.
    aDepartment of Cardiac, Thoracic and Vascular Sciences, Section of Respiratory Diseases, University of Padova, Padova, Italy bDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, The University of California at Davis, Sacramento, California, USA cNational Institute for Health Research Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, University of Southampton, Southampton, UK dDepartment of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
    Purpose Of Review: A number of recent studies have explored the possibility to apply personalized medicine to interstitial lung diseases (ILDs), particularly idiopathic pulmonary fibrosis (IPF), the most common and deadly of the idiopathic interstitial pneumonias. In our review, we summarize and discuss the most recent literature on personalized medicine in IPF as well as hypersensitivity pneumonitis and sarcoidosis, with emphasis on patient subgroups for which a personalized approach to disease prognostication and management may become a reality in the near future.

    Recent Findings: Most of the studies that have explored the applicability of personalized medicine to ILDs have been conducted in patients with IPF. Read More

    Granulomatous interstitial nephritis associated with Primary Sjögren's syndrome.
    Z Rheumatol 2017 Feb 14. Epub 2017 Feb 14.
    Internal Medicine/Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey.
    Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by lymphocytic and plasmacytic infiltration of the exocrine glands. Tubulointerstitial nephritis (TIN) is the most common type of renal involvement in pSS. However, clinically significant renal involvement is uncommon. Read More

    Genitourinary sarcoidosis: An essential review for the practicing clinician.
    Indian J Urol 2017 Jan-Mar;33(1):6-12
    Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA.
    Introduction: Sarcoidosis is a multisystem disease that commonly involves the lungs, but may also present with extrapulmonary manifestations. Genitourinary (GU) tract involvement has been traditionally thought to be rare, but that view may underestimate the true prevalence of the disease due to the often, silent presentation thereof.

    Methods: The literature pertaining to sarcoidosis from the general systemic point of view, etiology and therapy and with regard to specific organs was reviewed by identifying key words in a PubMed search. Read More

    [Sarcoidosis flare after autologous stem cell transplantation: An immune paradox?]
    Rev Med Interne 2017 Feb 10. Epub 2017 Feb 10.
    Service de médecine interne, institut E3M, centre national de référence maladies auto-immunes systémiques rares, hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; Université Pierre-et-Marie-Curie, université Paris VI, Sorbonne Université, Paris 75013, France. Electronic address:
    Introduction: Sarcoidosis is a systemic granulomatous disorder of unknown cause. Apparition or flare of previously diagnosed sarcoidosis following hematopoietic stem cell transplantation (HSCT) has rarely been reported.

    Observation: We report a 62-year-old woman who presented a radiological flare of sarcoidosis post-autologous stem cell transplantation for a POEMS syndrome. Read More

    Endobronchial Sarcoidosis.
    J Bronchology Interv Pulmonol 2017 Feb 10. Epub 2017 Feb 10.
    *Division of Internal Medicine †Division of Pulmonary, Allergy and Critical Care Medicine ‡Division of Pathology, Penn State College of Medicine, Hershey, PA §Division of Thoracic Surgery and Interventional Pulmonology, Swedish Cancer Institute/Swedish Medical Center, Seattle, WA.

    Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report.
    Am J Case Rep 2017 Feb 13;18:157-159. Epub 2017 Feb 13.
    Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
    BACKGROUND Laryngeal sarcoidosis is a rare extrapulmonary manifestation of sarcoidosis, accounting for 0.33-2.1% of cases. Read More

    Cutaneous adverse effects of the immune checkpoint inhibitors.
    Curr Probl Cancer 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatology, Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
    The immune checkpoint targeted agents, anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and anti-programed cell death 1 (PD-1) or anti-programmed death ligand 1 (PD-L1) inhibitors are frequently associated with cutaneous side effects that are often dose limiting and can lead to discontinuation of therapy. Ipilimumab, a CTLA-4 inhibitor, is most commonly associated with a morbilliform eruption on the trunk and extremities and pruritus. More severe cutaneous toxicities reported include toxic epidermal necrolysis and severe drug rash with eosinophila and systemic symptoms. Read More

    Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry.
    J Vis Exp 2017 Jan 20(119). Epub 2017 Jan 20.
    Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet;
    The lungs are constantly exposed to the external environment, which in addition to harmless particles, also contains pathogens, allergens, and toxins. In order to maintain tolerance or to induce an immune response, the immune system must appropriately handle inhaled antigens. Lung dendritic cells (DCs) are essential in maintaining a delicate balance to initiate immunity when required without causing collateral damage to the lungs due to an exaggerated inflammatory response. Read More

    Firm, non-tender mass in right breast · worsening, nonproductive cough · pleuritic pain · Dx?
    J Fam Pract 2017 Jan;66(1):38-41
    Department of Pathology, Stanford University School of Medicine, CA, USA.
    Granulomatous lesions, such as foreign body granuloma, idiopathic granulomatous mastitis (IGM), and sarcoidosis can mimic breast carcinoma. IGM is associated with elevated prolactin (eg, pregnancy or oral contraceptive use) and is usually subareolar. Infection, however, is also commonly subareolar. Read More

    HTLV-1 seroprevalance in sarcoidosis. A clinical and laboratory study in northeast of Iran.
    Int J Rheum Dis 2017 Feb 9. Epub 2017 Feb 9.
    Rheumatic Diseases Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    Aim: Sarcoidosis is an autoimmune multiorgan granulomatosis disease with unknown origin. Some environmental factors such as viruses may induce the disease in genetically susceptible individuals. Human T cell lymphotropic virus type 1 (HTLV-1) can dysregulate the human immune system and the role of this virus in the pathogenesis of autoimmune diseases has been investigated and documented, such as in uveitis. Read More

    Risk of cardiovascular disease among patients with sarcoidosis: a population-based retrospective cohort study, 1976-2013.
    Eur Respir J 2017 Feb 23;49(2). Epub 2017 Feb 23.
    Division of Rheumatology, Dept of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
    A higher incidence of cardiovascular disease (CVD) has been observed in several chronic inflammatory diseases. However, data on sarcoidosis are limited.In this study, 345 patients with incident sarcoidosis in Olmsted County (Minnesota, USA) during 1976-2013 were identified based on comprehensive medical record review. Read More

    Use of Narrow Band Imaging in the Diagnosis of Hypovascular Endobronchial Sarcoidosis.
    J Bronchology Interv Pulmonol 2017 Feb 8. Epub 2017 Feb 8.
    Division of Pulmonary and Critical Care Medicine, Greater Baltimore Medical Center, Baltimore, MD.
    Narrow band imaging (NBI) has been widely applied for the evaluation of numerous disease conditions that present with increased vascularity of the mucosa, most often malignancies. It is increasingly being used in benign conditions as well. We present the first case in which NBI was used, rather, to detect areas of bronchial hypovascularity due to its ability to increase the visual contrast between normal and hypovascular mucosa. Read More

    Coexistent Sarcoidosis and Tuberculosis: A Case Report.
    Respiration 2017 Feb 9. Epub 2017 Feb 9.
    Department of Medical and Surgical Sciences, Institute of Respiratory Diseases, Azienda Ospedaliero Universitaria Foggia, Foggia, Italy.
    Necrotizing granulomatous diseases of the lungs are usually dependent on a narrow range of differential diagnoses. Tuberculosis (TB) is responsible for the largest number of cases, while necrotizing sarcoidosis is generally considered a rare and easily distinguishable disease substantially based on histological features. However, this entity has become a viable diagnosis in the absence of mycobacteria isolation or when a remarkable clinical improvement cannot be achieved with the combination of anti-TB drugs at full dosage. Read More

    Sarcoidosis Increases Risk of Hospitalized Infection: A Population-Based Study 1976-2013.
    Ann Am Thorac Soc 2017 Feb 8. Epub 2017 Feb 8.
    Mayo Clinic, Rheumatology, Rochester, Minnesota, United States ;
    Rationale: Patients with sarcoidosis may have an increased risk of infection similar to other immune-mediated disorders. However, the data are still limited.

    Objectives: To investigate the risk of hospitalized infection among patients with sarcoidosis using a population-based cohort. Read More

    Ablation of Ventricular Tachycardia in Congenital and Infiltrative Heart Disease.
    Card Electrophysiol Clin 2017 Mar 24;9(1):107-117. Epub 2016 Dec 24.
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
    Radiofrequency catheter ablation (RFCA) is an important treatment modality to prevent ventricular tachycardia (VT) recurrence in patients with repaired congenital heart disease. Identification and ablation of anatomic isthmuses has improved acute ablation outcome with excellent VT-free survival in those with preserved biventricular function. Reports on RFCA for VT in patients with infiltrative disease are sparse and cardiac sarcoidosis seems to be the most prevalent cause for ventricular arrhythmia. Read More

    Papulo-Nodular Reactions in Black Tattoos as Markers of Sarcoidosis: Study of 92 Tattoo Reactions from a Hospital Material.
    Dermatology 2017 Feb 7. Epub 2017 Feb 7.
    Wound Healing Centre, Bispebjerg University Hospital, Copenhagen, Denmark.
    Background/aims: Sarcoidosis is, from historical data, suggested to be more prevalent among patients with tattoo reactions. We aimed to evaluate this association in a systematic study.

    Methods: This is a consecutive study of patients with tattoo complications, diagnosed in the "Tattoo Clinic" at Bispebjerg University Hospital in Copenhagen, Denmark, from 2008 to 2015, based on clinical assessment and histology. Read More

    Humoral immune profiling of mycobacterial antigen recognition in sarcoidosis and Löfgren's syndrome using high-content peptide microarrays.
    Int J Infect Dis 2017 Jan 31. Epub 2017 Jan 31.
    Centre for Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Huddinge, Sweden; Division of Therapeutic Immunology (TIM), Department of Laboratory Medicine (LABMED), Karolinska Institutet, Huddinge 14186, Stockholm, Sweden. Electronic address:
    Introduction: Sarcoidosis is considered an idiopathic granulomatous disease, although similar immunological and clinical features with tuberculosis (TB) suggest mycobacterial involvement in its pathogenesis. High-content peptide microarrays (HCPM) may help to decipher mycobacteria-specific antibody reactivity in sarcoidosis.

    Methods: Serum samples from patients with sarcoidosis, Löfgren's syndrome, and TB, as well as from healthy individuals (12/group), were tested on HCPM containing 5964 individual peptides spanning 154 Mycobacterium tuberculosis proteins displayed as 15-amino acid stretches. Read More

    [Pulmonary sarcoidosis presenting as multiple scattered pulmonary nodules: about a case].
    Pan Afr Med J 2016 3;24:295. Epub 2016 Aug 3.
    Service de Médecine Interne, Hôpital Razi, la Manouba 2010, Faculté de Médecine de Tunis, Tunis Tunisie.
    Sarcoidosis is a multisystem granulomatous disease that can affect all organs, thoracic involvement often predominates representing its most evocative manifestation. Atypical manifestations, such as the presence of multiple scattered pulmonary nodules may indicate malignancy. Our study reports the case of a 56-year-old patient investigated for asthenia associated with paresthesia of the lower limbs evolving since 6 months. Read More

    Role of Imaging in Evaluating Infiltrative Heart Disease.
    Curr Treat Options Cardiovasc Med 2017 Jan;19(1)
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
    Opinion Statement: Infiltrative heart disease is caused by the deposition of abnormal substances in the heart and can lead to abnormalities in cardiac function and electrical conduction. Advances in non-invasive cardiovascular imaging have allowed for improved diagnosis of infiltrative heart disease, as well as ways to track disease progression or regression, thus enabling a mechanism to follow response to therapy. In this review, we provide an overview of the role of imaging in the diagnosis and management of cardiac sarcoidosis (CS) and cardiac amyloidosis (CA), as well as outline a proposed algorithm for using non-invasive cardiovascular imaging for evaluating these conditions. Read More

    Two men with dyspnea, enlarged lymph nodes · Dx?
    J Fam Pract 2016 Dec;65(12):916-920
    Division of Internal Medicine, Kaplan Medical Center, Rehovot, Israel. Email:
    Systolic heart failure has been previously recognized as a cause of reversible mediastinal lymphadenopathy (MLN). Other causes of MLN include sarcoidosis, various malignancies, pulmonary infections, and occupational lung diseases. There are, however, no reports of MLN in patients with diastolic heart failure. Read More


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