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    Diagnostic Yield of Transbronchial Biopsy in Comparison to High Resolution Computerized Tomography in Sarcoidosis Cases
    Asian Pac J Cancer Prev 2018 Apr 25;19(4):1029-1033. Epub 2018 Apr 25.
    Department of Pulmonary Medicine , Medical Faculty, Gazi University, Ankara, Turkey. Email: nkokturk©gmail.com
    This study aimed to evaluate the diagnostic yield of fiberoptic bronchoscopic (FOB) transbronchial biopsy and its relation with quantitative findings of high resolution computerized tomography (HRCT). A total of 83 patients, 19 males and 64 females with a mean age of 45.1 years diagnosed with sarcoidosis with complete records of high resolution computerized tomography were retrospectively recruited during the time period from Feb 2005 to Jan 2015. Read More

    Comparison between optical coherence tomography angiography and fluorescein angiography findings in retinal vasculitis.
    Int J Retina Vitreous 2018 16;4:15. Epub 2018 Apr 16.
    1Departamento de Oftalmologia, Universidade Federal de São Paulo, Rua Botucatu, 821 - Vila Clementino, São Paulo, SP 04023-062 Brazil.
    Background: To describe optical coherence tomography angiography (OCT-A) findings in patients with retinal vasculitis and to compare them to current fluorescein angiography (FA) findings.

    Methods: This was an observational case series. Nineteen eyes in 10 patients with retinal vasculitis of various etiologies were imaged with FA (TRC-50DX, Topcon) and OCT-A (SD-OCT, Optovue). Read More

    Musculoskeletal manifestations of sarcoidosis: A review article.
    Curr Rheumatol Rev 2018 Apr 24. Epub 2018 Apr 24.
    Department of Rheumatology, Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad. Iran.
    Sarcoidosis is a multisystem inflammatory disease with an etiology that is not clearly understood. Amongst the different organs that may be affected, the lungs are the most common. Musculoskeletal manifestations of the disease are uncommon. Read More

    [Pulmonary tuberculosis in diagnostic imaging: the great mime.]
    Recenti Prog Med 2018 Apr;109(4):220-225
    Dipartimento di Radiologia, Ospedale Monaldi AO dei Colli, Napoli.
    Pulmonary tuberculosis (TB) is nowadays one of the most common causes of infectious disease-related morbility and mortality worldwide. The differential diagnosis between TB and some others conditions is an emerging problem, particularly challenging when TB imaging mimicks sarcoidosis, lymphoproliferative disorders and pulmonary neoplasms. In these cases, the correct diagnoses can be made with certainty only with trans-bronchial or CT guided biopsy. Read More

    Sarcoidosis Related Novel Candidate Genes Identified by Multi-Omics Integrative Analyses.
    OMICS 2018 Apr 24. Epub 2018 Apr 24.
    1 Clinical Institute of Medical Genetics, University Medical Centre Ljubljana , Ljubljana, Slovenia .
    Sarcoidosis is a multifactorial systemic disease characterized by granulomatous inflammation and greatly impacting on global public health. The etiology and mechanisms of sarcoidosis are not fully understood. Recent high-throughput biological research has generated vast amounts of multi-omics big data on sarcoidosis, but their significance remains to be determined. Read More

    The Utility of F-FDG PET/CT for Monitoring Response and Predicting Prognosis after Glucocorticoids Therapy for Sarcoidosis.
    Biomed Res Int 2018 1;2018:1823710. Epub 2018 Mar 1.
    Department of Respiratory Disease, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
    Sarcoidosis has significant heterogeneity involving multiple organs; treatment of the disease is a significant therapeutic challenge due to the difficulties in accurately monitoring disease activity and estimating prognosis. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG-PET/CT) plays an important role in assessing the metabolic activity. However, there is not enough evidence about the influence of this method in the clinical management and prognosis prediction for sarcoidosis. Read More

    Soluble Interleukin-2 Receptor: A Potential Marker for Monitoring Disease Activity in IgG4-Related Disease.
    Mediators Inflamm 2018 1;2018:6103064. Epub 2018 Mar 1.
    Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.
    Background: IgG4-related disease (IgG4-RD) is a fibroinflammatory condition. T-cells play a crucial role in the pathogenesis, and therefore, serum soluble interleukin-2 receptor (sIL-2R) may be a potential biomarker.

    Method: We studied the levels of sIL-2R in 26 histologically proven IgG4-RD patients with available serum sIL-2R and compared them to those in newly diagnosed and untreated sarcoidosis patients ( = 78) and controls ( = 101) and the serum sIL-2R levels in patients after treatment of IgG4-RD ( = 15). Read More

    A cavernous sinus lesion clinically responsive to steroids.
    J Clin Neurosci 2018 Apr 20. Epub 2018 Apr 20.
    Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA. Electronic address:
    Tolosa Hunt syndrome (THS) is characterized by painful ophthalmoplegia secondary to idiopathic granulomatous inflammation of the cavernous sinus. The characteristic finding on MRI is an enhancing T1 isointense and T2 hypo- or hyperintense cavernous sinus mass lesion, which may result in focal narrowing of the ipsilateral internal carotid artery. Although the incidence is quite rare, it is a common diagnostic consideration in cases that present with multiple cranial neuropathies. Read More

    Spontaneous Reduction in Abnormal Myocardial Uptake of Fluorine-18 Fluorodeoxygluose in a Patient with Cardiac Sarcoidosis.
    Int Heart J 2018 Apr 20. Epub 2018 Apr 20.
    Department of Cardiology, Osaka Medical College.
    Fluorine-18 fluorodeoxygluose (F-FDG) positron emission tomography (PET) is a useful tool for evaluating disease activity in sarcoidosis including cardiac involvement. A 67-year-old patient who developed atrioventricular block requiring permanent pacemaker implantation was diagnosed with cardiac sarcoidosis. The patient did not undergo steroid or immunosuppressive therapy but underwent serial F-FDG PET examination, which showed spontaneous reduction in the myocardial FDG uptake, indicating the remission of immune-inflammatory activity. Read More

    Proangiogenic and Profibrotic Markers in Pulmonary Sarcoidosis.
    Adv Exp Med Biol 2018 Apr 21. Epub 2018 Apr 21.
    Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, Bonn, Germany.
    The aim of our study was to determine the blood levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, fibroblast growth factor (FGF)-2, and platelet-derived growth factor (PDGF)-AB in different stages of pulmonary sarcoidosis. There were 92 patients in sarcoidosis stages I + II, III, and IV enrolled into the study. All the patients underwent lung diffusing capacity and blood sampling. Read More

    [Dermatologic toxicities of immune checkpoint inhibitors].
    Ann Dermatol Venereol 2018 Apr 17. Epub 2018 Apr 17.
    Oncodermatologie, institut universitaire du cancer Toulouse Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
    The development of immune checkpoint inhibitors (monoclonal antibodies targeting PD-1/PD-L1 or CTLA-4) represents a significant advance in the treatment of multiple cancers. Given their particular mechanism of action, which involves triggering CD4+/CD8+ T-cell activation and proliferation, they are associated with a specific safety profile. Their adverse events are primarily immune-related, and can affect practically all organs. Read More

    Utility and safety of endobronchial ultrasound-guided transbronchial needle aspiration in patients with mediastinal and hilar lymphadenopathy: Western region experience.
    Ann Thorac Med 2018 Apr-Jun;13(2):92-100
    Department of Internal Medicine, Faculty of Medicine, King Abdul Aziz University, Jeddah, Saudi Arabia.
    Aims: The aim of the study was to evaluate the clinical utility and safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with mediastinal and hilar lymphadenopathy and to explicitly describe the utility of this procedure in patient's outcome.

    Methods: A retrospective review and analysis was conducted on 52 patients with mediastinal or hilar lymphadenopathy who underwent EBUS-TBNA from June 2012 to June 2016. All the patients were evaluated by computed tomography (CT) chest with contrast before EBUS examination. Read More

    An atypical case of neurosarcoidosis presenting with neovascular glaucoma.
    J Ophthalmic Inflamm Infect 2018 Apr 18;8(1). Epub 2018 Apr 18.
    Department of Ophthalmology, University Hospital Ghent, De Pintelaan 185, 9000, Ghent, Belgium.
    Background: Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative.

    Findings: A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Read More

    Comparing the Differential Diagnostic Values of F-Alfatide II PET/CT between Tuberculosis and Lung Cancer Patients.
    Contrast Media Mol Imaging 2018 19;2018:8194678. Epub 2018 Feb 19.
    Department of Nuclear Medicine, Affiliated Hospital of Jiangnan University (Wuxi No. 4 People's Hospital), Wuxi, China.
    Purpose: To compare the differential diagnostic values of F-Alfatide II PET/CT between tuberculosis and lung cancer patients and in patients with sarcoidosis and common inflammation.

    Methods: Nine inflammation patients (4 tuberculosis, 3 sarcoidosis, and 2 common inflammation) and 11 lung cancer patients were included in this study. All patients underwent F-FDG and F-Alfatide II PET/CT within 2 weeks, followed by biopsy and surgery. Read More

    Sarcoid-Like Mediastinal Lymphadenopathy in Gynecologic Malignancy.
    Pulm Med 2018 14;2018:5141575. Epub 2018 Feb 14.
    Pulmonary-Critical Care Medicine, Abington Jefferson Health, Abington, PA, USA.
    Noncaseating granulomas are seen surrounding tumors with varying frequency, possibly as part of an immune response to tumor cells. However, data about the association of sarcoid with gynecologic malignancy is sparse. We performed a search of our institutional database for all EBUS-TBNA biopsies conducted within the past five years that revealed granulomatous inflammation. Read More

    A Glimpse into Uveitis in the Aging Eye: Pathophysiology, Clinical Presentation and Treatment Considerations.
    Drugs Aging 2018 Apr 16. Epub 2018 Apr 16.
    University of Miami Miller School of Medicine, Miami, FL, USA.
    Uveitis describes a group of inflammatory conditions of the eye that have various underlying causes and clinical presentations. Susceptibilities to uveitis in the elderly may be attributed to age-related risk factors such as immunosenescence, increased immunological inflammatory mediators, and autoimmunity. Overall, anterior uveitis is more common than posterior and panuveitis in the general population and also in the elderly. Read More

    Frequency of Aquaporin-4 Immunoglobulin G in Longitudinally Extensive Transverse Myelitis With Antiphospholipid Antibodies.
    Mayo Clin Proc 2018 Apr 11. Epub 2018 Apr 11.
    Department of Neurology, Mayo Clinic, Rochester, MN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address:
    Antiphospholipid (aPL) antibodies have historically been postulated to cause a poorly understood inflammatory myelitis. Neuromyelitis optica spectrum disorder (NMOSD) causes an inflammatory longitudinally extensive transverse myelitis (LETM). In 2004, aquaporin-4 immunoglobulin G (AQP4-IgG) was first reported as a highly specific (>99%) serum diagnostic biomarker of NMOSD, distinguishing it from other disorders (eg, multiple sclerosis). Read More

    A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report.
    J Med Case Rep 2018 Apr 13;12(1):94. Epub 2018 Apr 13.
    Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, 300 Cedar Street, TAC 441 South, P.O. Box 208057, New Haven, CT, 06520, USA.
    Background: Sarcoidosis is a multisystem, chronic granulomatous disease of unknown etiology that predominantly affects the lungs. Pulmonary sarcoidosis classically presents with constitutional symptoms and computed tomographic scan findings of bilateral, symmetric micronodules in a peribronchovascular distribution with upper and middle lung zone predominance accompanied by bilateral, symmetric hilar lymphadenopathy. A solitary lung mass is a rare finding for pulmonary sarcoidosis, and with its associated constitutional symptoms, it strongly mimics a malignancy. Read More

    [Perioperative onset of sarcoidosis : Rare differential diagnosis of a difficult airway].
    Anaesthesist 2018 Apr 11. Epub 2018 Apr 11.
    Klinik für Anästhesiologie und Intensivmedizin, Notfallmedizin und Schmerztherapie, Städtisches Klinikum Dresden Friedrichstadt, Dresden, Deutschland.
    Sarcoidosis is a rare multisystemic chronic inflammatory condition. Typically, there is a big discrepancy between the patient's subjectively perceived symptoms and the presence of clinical signs. Due to the high number of potential sites of onset (e. Read More

    Granuloma Annulare Skin Lesions in a Case of Sarcoidosis.
    Indian Dermatol Online J 2018 Mar-Apr;9(2):117-119
    Department of Dermatology, Base Hospital, Delhi Cantt, New Delhi, India.
    We report the case of a 32-year- old man with a short 3-week history of erythematous, annular, non scaly plaques on palmar and dorsal aspect of his hands, who was concurrently diagnosed as a case of sarcoidosis on the basis of findings of generalized lymphadenopathy and radiological and histological features of pulmonary sarcoidosis. His skin biopsy was consistent with the diagnosis of granuloma annulare. Sarcoidosis and granuloma annulare are two separate diseases, which involve the skin and have a mononuclear histiocytic cellular reaction, although their aetiology is still unknown. Read More

    A Rare Case of Sarcoidosis Presenting as Diffuse Contracturing Granulomatous Myositis on Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.
    Indian J Nucl Med 2018 Apr-Jun;33(2):148-151
    Department of Nuclear Medicine, MIOT International, Chennai, Tamil Nadu, India.
    Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is an established imaging modality in diagnosis and treatment response monitoring of sarcoidosis. Multisystemic involvement of sarcoidosis is characteristically seen on PET/CT; however, isolated organ involvement is rare. We describe here a case of a 52-year-old male with generalized muscle weakness, an extremely rare clinical manifestation of sarcoidosis. Read More

    Role of serum immunoglobulins for predicting sarcoidosis outcome: A cohort study.
    PLoS One 2018 11;13(4):e0193122. Epub 2018 Apr 11.
    Internal Medicine Department, Rennes University Hospital, Rennes, France.
    Background: Sarcoidosis is a systemic granulomatous disease which carries variable outcomes. Serum protein electrophoresis is an easily accessible and routinely performed examination at diagnosis, in order to search for hypergammaglobulinemia, which is frequently found, and to rule out other granulomatous diseases such as common variable immunodeficiency. We aimed to assess the impact of baseline immunoglobulin level on the outcome of sarcoidosis. Read More

    Not everything is as it seems: neurosarcoidosis presenting as leptomeningitis.
    Clin Case Rep 2018 Apr 13;6(4):596-602. Epub 2018 Feb 13.
    American British Cowdray Medical CenterMexico CityMexico.
    Involvement of the central nervous system in sarcoidosis is rare; neurosarcoidosis, although unusual, can present as leptomeningitis. The diagnosis is usually difficult because of the vague and broad symptomatology; therefore, a prompt diagnosis should be made, and adequate treatment should be administered to reduce morbidity and mortality. Read More

    Prevalence, incidence, and mortality of sarcoidosis in Korea, 2003-2015: A nationwide population-based study.
    Respir Med 2018 Apr 3. Epub 2018 Apr 3.
    Division of Pulmonology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Gyeonggi-do, Republic of Korea; Department of Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Background: The prevalence and incidence of sarcoidosis, a granulomatous disorder involving multiple organ systems, varies among geographical regions and ethnicities. This study evaluated the incidence, prevalence, and mortality of sarcoidosis in a large nationwide population-based cohort in Korea.

    Methods: We used data of the National Health Insurance Service database, which is an extensive health-related database including most Korean residents. Read More

    Pulmonary Hydatid Disease with Aspergillosis - An Unusual Association in an Immunocompetent Host.
    Turk Patoloji Derg 2018 Apr 9. Epub 2018 Apr 9.
    Department of Pathology, Dayanand Medical College and Hospital, LUDHIANA, INDIA.
    Echinococcosis is a common cause of pulmonary cavities. Aspergillus fumigatus, a saprophytic fungus, can colonise pulmonary cavities caused by tuberculosis, sarcoidosis, echinococcosis, bronchiectasis and neoplasms. Infection by Aspergillus is often seen in immunosuppressed cases. Read More

    A Case of a Cardiac Resynchronization Therapy-Defibrillator Exhibiting a Lower and Alternately Variable Basic Rate.
    Int Heart J 2018 Apr 6. Epub 2018 Apr 6.
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.
    A cardiac resynchronization therapy defibrillator (CRT-D) (Medtronic Inc. Protecta XT) was implanted in a 67-year-old man who had cardiac sarcoidosis with extremely low cardiac function. He had ventricular tachycardia which was controlled by catheter ablation, medication and pacing. Read More

    Sleep disturbance and symptom burden in sarcoidosis.
    Respir Med 2018 Mar 24. Epub 2018 Mar 24.
    University of California, San Francisco, Division of Pulmonary and Critical Care, 505 Parnassus Ave, San Francisco, CA 94143, USA. Electronic address:
    Introduction: Sarcoidosis is a systemic inflammatory disease associated with myriad symptoms, including fatigue. It can affect physiological processes like sleep, leading to poor sleep quality and excessive daytime sleepiness. We hypothesized that sarcoidosis patients would report more severe sleep disturbance than healthy controls and that relationships would be found with sleep disturbance and the severity of other symptoms. Read More

    Nuclear Imaging in Sarcoidosis.
    Semin Nucl Med 2018 May 9;48(3):246-260. Epub 2018 Mar 9.
    Nuclear Medicine Department and DHU FIRE, Bichat-Claude Bernard Hospital, AP-HP, France; University Paris-Diderot, Paris, France; Inserm UMR-S 1148, Paris, France. Electronic address:
    Sarcoidosis is a multisystem granulomatosis which may result in a wide variety of clinical and biological presentations. Symptoms are often nonspecific, and incidental abnormal findings on chest radiography is rather common. Although sarcoidosis resolves favorably in most cases, some localizations can provoke functional impairment or even impact on patients' prognosis. Read More

    Imaging Macrophage-associated Inflammation.
    Semin Nucl Med 2018 May 13;48(3):242-245. Epub 2018 Feb 13.
    Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:
    Macrophages belong to the mononuclear phagocyte system comprising closely related cells of bone marrow origin. Activated macrophages are critical in several diseases such as tuberculosis, sarcoidosis, Crohn's disease, and atherosclerosis. Noninvasive imaging techniques that can specifically image activated macrophages could therefore help in differentiating various forms of inflammatory diseases and to monitor therapeutic responses. Read More

    Systemic inflammatory disorders in patients admitted for aseptic meningitis.
    Clin Med (Lond) 2018 Mar;18(2):132-137
    Bichat Hospital, Paris, France
    Acute meningitis can be the first manifestation of an underlying systemic inflammatory disorder (SID). In the current study, we aimed to identify clinical indicators for SIDs in patients admitted for acute aseptic meningitis. All patients hospitalised for acute aseptic meningitis over a 4-year period in a department of internal medicine were included retrospectively. Read More

    Pulmonary sarcoidosis.
    Lancet Respir Med 2018 Apr 3. Epub 2018 Apr 3.
    Royal Brompton and Harefield National Health Service Foundation Trust, Interstitial Lung Disease Unit, London, UK.
    Sarcoidosis is a granulomatous disease of unknown cause, occurs worldwide and has a highly variable prevalence. The disease is typically dominant in the lungs, although it can affect virtually any organ and is unpredictable in its clinical course. The severity of pulmonary sarcoidosis ranges from incidentally discovered radiographic abnormalities in asymptomatic patients to a chronic progressive disease that is refractory to treatment. Read More

    Craniofacial Manifestations of Systemic Disorders: CT and MR Imaging Findings and Imaging Approach.
    Radiographics 2018 Apr 6:170145. Epub 2018 Apr 6.
    From the Departments of Radiology (V.C.A.A., M.N.C., H.K., A.F., O.S.), Otolaryngology-Head and Neck Surgery (O.S.), and Radiation Oncology (O.S.), Boston University Medical Center, Boston University School of Medicine, 820 Harrison Ave, 3rd Floor, Boston, MA 02118.
    Many systemic diseases or conditions can affect the maxillofacial bones; however, they are often overlooked or incidentally found at routine brain or head and neck imaging performed for other reasons. Early identification of some conditions may significantly affect patient care and alter outcomes. Early recognition of nonneoplastic hematologic disorders, such as thalassemia and sickle cell disease, may help initiate earlier treatment and prevent serious complications. Read More

    Qualitative Methods to Advance Care, Diagnosis, and Therapy in Rheumatic Diseases.
    Rheum Dis Clin North Am 2018 May 21;44(2):267-284. Epub 2018 Feb 21.
    Royal National Hospital for Rheumatic Diseases, Royal United Hospitals, Upper Borough Walls, Bath BA1 1RL, UK; Department of Pharmacy and Pharmacology, University of Bath, Bath BA11RL, UK.
    This article provides an overview of the basis, usefulness, and validity of qualitative methods in research. It is aimed to enhance the understanding of a broad spectrum of readers, ranging from those mystified by such approaches, to those wanting a better critical knowledge to apply to literature review, and for health care providers considering developing an interest in the field. Qualitative research is crucial in augmentation of disease knowledge as well as the development of incremental care strategies and operational aspects of care that improves health outcomes. Read More

    Clinical presentation, management and prognosis of patients with cardiac sarcoidosis.
    Dan Med J 2018 Apr;65(4)
    Introduction: The course and prognosis of cardiac sarcoidosis (CS) are sparsely described. The purpose of this study was to assess the clinical presentation, treatment response and prognosis for patients with CS.

    Methods: This was a single-centre retrospective study of patients with CS from 2006 to 2016. Read More

    Aortic sarcoidosis complicated by a pulmonary artery aneurysm.
    Eur J Cardiothorac Surg 2018 Mar 29. Epub 2018 Mar 29.
    Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
    A 76-year-old woman, who had a history of ocular sarcoidosis, was incidentally found to have a huge pulmonary artery aneurysm, along with aortic, mitral and tricuspid valve insufficiency. She underwent pulmonary artery plication along with surgeries for 3 valves. A specimen of the slightly enlarged ascending aorta revealed the involvement of sarcoidosis in the aortic wall. Read More

    Tubulointerstitial nephritis and uveitis (TINU) with granulomatosis: a novel report of simultaneous TINU and sarcoidosis in a pediatric patient.
    J AAPOS 2018 Mar 31. Epub 2018 Mar 31.
    Department of Ophthalmology, University of Maryland School of Medicine, Baltimore; Department of Pediatrics, University of Maryland School of Medicine, Baltimore.

    Isolated Mediastinal Lymphadenopathy Caused by Rhodococcus equi Infection.
    Ann Thorac Surg 2018 Mar 31. Epub 2018 Mar 31.
    Department of Thoracic surgery, Tartu University Hospital, Estonia.
    Mediastinal lymphadenopathy is common finding in thoracic surgery, which often requires morphological confirmation to establish the definite diagnosis. The most frequent diagnoses are metastatic lung cancer, sarcoidosis, lymphoma, tuberculosis and other causes of granulomatous infections. Rhodococcus equi is a rare pathogen in humans, mostly affecting immunocompromised patients. Read More

    Focal Myocardial Damage in Cardiac Sarcoidosis Characterized by Strain Analysis on Magnetic Resonance Tagged Imaging in Comparison with Fluorodeoxyglucose Positron Emission Tomography Accumulation and Magnetic Resonance Late Gadolinium Enhancement.
    J Comput Assist Tomogr 2018 Apr 2. Epub 2018 Apr 2.
    Objective: The aims of this study were to characterize focal myocardial damage of cardiac sarcoidosis by strain analysis and to compare it with late gadolinium enhancement (LGE) and fluorodeoxyglucose (FDG) positron emission tomography.

    Methods: We reviewed 208 segments from 13 cardiac sarcoidosis patients and measured the circumferential strain (Ecc) and the strain change per second (Ecc rate). The mean Ecc and Ecc rate values were compared between the FDG(+) and FDG(-), and the LGE(+) and LGE(-) segments using Welch's t test. Read More

    Prognostic role of serial quantitative evaluation of F-fluorodeoxyglucose uptake by PET/CT in patients with cardiac sarcoidosis presenting with ventricular tachycardia.
    Eur J Nucl Med Mol Imaging 2018 Apr 2. Epub 2018 Apr 2.
    Division of Nuclear Medicine, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA, 19104, USA.
    Background: Positron emission tomography (PET) with F-fluorodeoxyglucose (FDG) has shown to be useful in diagnosis, staging and monitoring of cardiac sarcoidosis (CS) but its interpretation is not standardized.

    Objectives: We sought to investigate the clinical impact of serial quantitative FDG uptake analysis in patients with CS presenting with ventricular tachycardia (VT) treated by catheter ablation (CA).

    Methods: We followed 20 patients (51 ± 9 years, 70% males) with CS and VT who underwent CA, with 92 serial FDG-PET scans (3-10 per patient). Read More

    Pulmonary Sarcoidosis following Etanercept Treatment for Ankylosing Spondylitis: A Case Report and Review of the Literature.
    Case Rep Rheumatol 2018 23;2018:9867248. Epub 2018 Jan 23.
    Rheumatology Department, Mohammed V Military Academic Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
    Antitumor necrosis factor therapies have revolutionized the treatment of some inflammatory diseases. However, the use of these agents is associated with the development of many paradoxical autoimmune diseases. Less well-recognized is the association with sarcoidosis. Read More

    An unusual presentation of neurosarcoidosis with progressive hearing loss.
    Pan Afr Med J 2017 7;28:213. Epub 2017 Nov 7.
    Department of Neurology, Military Hospital Moulay Ismail, Meknes, Morocco.
    Sarcoidosis is a granulomatous disease of unknown etiology that can involve several organ system. Neurological manifestations are not common and mostly include cranial neuropathies. However, auricular disorders are rare and exceptionally inaugural. Read More

    Falsely Elevated CA 15-3 Levels in Ovarian Sarcoidosis with Peritoneal Involvement and Ascites.
    Case Rep Obstet Gynecol 2018 22;2018:2039730. Epub 2018 Jan 22.
    2nd Department of Pathology, University of Athens Medical School, "Attikon" University Hospital, Athens, Greece.
    A rare case of ovarian sarcoidosis with peritoneal and omental involvement presenting as an ovarian malignancy is presented. Clinical, laboratory, and radiological evaluation of the patient revealed ascites and high levels of serum CA 125 and CA 15.3. Read More

    Pulmonary hypertension in patients with interstitial lung disease.
    Pulm Pharmacol Ther 2018 Mar 29. Epub 2018 Mar 29.
    Section of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. Electronic address:
    Interstitial lung diseases (ILDs) comprise a broad and heterogeneous group of more than two hundred diseases with common functional characteristics. Their diagnosis and management require a multidisciplinary approach. This multidisciplinary approach involves the assessment of comorbid conditions including pulmonary hypertension (PH) that exerts a dramatic impact on survival. Read More

    [Rehabilitation of patients with sarcoidosis].
    Pol Merkur Lekarski 2018 Mar;44(261):150-151
    Rehabilitation Department, Gdansk Medical University.
    Comprehensive rehabilitation programs have so far been developed for many chronic diseases. It has been proven that their use can be safe and effective in lung diseases such as chronic obstructive pulmonary disease. There are still no standards of rehabilitation in the group of patients with sarcoidosis available. Read More

    [Disturbances of calcium metabolism and vitamin D supplementation in sarcoidosis - two-way street].
    Pol Merkur Lekarski 2018 Mar;44(261):147-149
    1st Department of Lung Diseases, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
    The role of vitamin D in the human body is not limited only to the regulation of calcium metabolism and secondary to the impact on bones. Recent studies have shown the influence of vitamin D level on muscles, on the risk of cancer, diabetes, hypertension and pulmonary diseases, including granulomatous diseases. Sarcoidosis is a granulomatous disease of unknown etiology. Read More

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