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    Isolated Cardiac Sarcoidosis Mimicking Arrhythmogenic Right Ventricular Cardiomyopathy.
    Intern Med 2017 Dec 8. Epub 2017 Dec 8.
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Japan.
    The diagnosis of cardiac sarcoidosis (CS) has become easier due to advances in imaging modalities, but we sometimes encounter difficult-to-diagnose patients. We herein report the case of a 60-year-old Japanese woman who was diagnosed with isolated CS, although she also met the diagnostic criteria of arrhythmogenic right ventricular cardiomyopathy (ARVC). A histological examination by an endomyocardial biopsy of the right ventricle revealed the typical findings of granulomatous change for CS. Read More

    Evaluation of QT dispersion and T-peak to T-end interval in patients with early-stage sarcoidosis.
    Rev Port Cardiol 2017 Dec 7. Epub 2017 Dec 7.
    Yıldırım Beyazıt University, Faculty of Medicine, Department of Cardiology, Ankara, Turkey.
    Introduction And Aim: Sarcoidosis increases inhomogeneity in ventricular repolarization due to the presence of sarcoid granuloma, which significantly correlates with ventricular fibrillation. Various studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (T-peak to T-end [Tpe] interval) may correspond to the transmural dispersion of repolarization and that increased Tpe interval and Tpe/QT ratio are associated with malignant ventricular arrhythmias. The present study hypothesized that QT and Tpe intervals are significantly prolonged in sarcoidosis patients without apparent cardiac involvement. Read More

    The pathogenesis of pulmonary sarcoidosis and implications for treatment.
    Chest 2017 Dec 7. Epub 2017 Dec 7.
    Johns Hopkins University School of Medicine, Baltimore, MD.
    Thoracic sarcoidosis is the most common form of sarcoidosis, encompassing a heterogeneous group of patients with a wide range of clinical features and associated outcomes. The distinction between isolated thoracic lymphadenopathy and pulmonary involvement matters. Morbidity is often higher, and long-term outcomes are worse for the latter. Read More

    [Atypical computed tomography manifestations of thoracic sarcoidosis].
    Zhonghua Jie He He Hu Xi Za Zhi 2017 Dec;40(12):925-930
    Department of Radiology, Shanghai Pulmonary Hospitial, Tongji University School of Medicine, Shanghai 200433, China.
    Objective: This study evaluated the atypical computed tomography (CT) manifestations of thoracic sarcoidosis. Methods: Medical data of 190 patients with thoracic sarcoidosis were retrospectively reviewed. Results: The atypical CT manifestations of thoracic sarcoidosis observed were unilateral hilar lymphadenopathy with or without mediastinal lymphadenopathy(n=12, 6. Read More

    [Two cases of granuloma annulare under anti-PD1 therapy].
    Ann Dermatol Venereol 2017 Dec 5. Epub 2017 Dec 5.
    EA3181, service de dermatologie, université de Bourgogne-Franche-Comté, CHU, 3, boulevard Fleming, 25030 Besançon, France.
    Background: Granuloma annulare as a granulomatous cutaneous reaction may be drug-induced. Immune checkpoint inhibitors including programmed death-1 (PD-1) inhibitors show remarkable antitumor activity and are approved for melanoma and other cancers. Different immune-related adverse effects have been described. Read More


    Reach and grasp deficits following damage to the dorsal pulvinar.
    Cortex 2017 Nov 8;99:135-149. Epub 2017 Nov 8.
    Department of Neurology, University Medicine Goettingen, Goettingen, Germany; DFG Center for Nanoscale Microscopy & Molecular Physiology of the Brain (CNMPB), Germany.
    Expansion of the dorsal pulvinar in humans and its anatomical connectivity suggests its involvement in higher-order cognitive and visuomotor functions. We investigated visuomotor performance in a 31 year old patient (M.B. Read More

    Serial FDG-PET/CT Imaging in the Management of Cardiac Sarcoidosis.
    Clin Nucl Med 2017 Dec 5. Epub 2017 Dec 5.
    From the Department of Radiology, University of Illinois Hospital and Health Sciences System, Chicago, IL.
    A 60-year-old woman with biopsy-proven cardiac sarcoidosis status post implantable cardioverter defibrillator placement presented with periodic dizziness and dyspnea on exertion. Myocardial perfusion scan demonstrated a moderate sized, fixed perfusion defect along the mid to proximal anteroseptal wall of the left ventricle, with better perfusion on stress images. FDG-PET/CT demonstrated corresponding focal FDG avidity of the mid to proximal anteroseptal wall, suggestive of active cardiac sarcoidosis. Read More

    Interstitial lung disease: the diagnostic role of bronchoscopy.
    J Thorac Dis 2017 Sep;9(Suppl 10):S996-S1010
    Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, University of Oklahoma Health Sciences Center and Oklahoma City VA Medical Center, Oklahoma, USA.
    Interstitial lung diseases (ILDs) form one of the most fascinating fields in pulmonary medicine. They also pose one of the greatest challenges for accurate diagnosis and proper treatment. Even within the recommended and warranted multidisciplinary approach, differentiating between one disease and another may lead to frustration, especially when proper lung tissue is not available for adequate pathological review. Read More

    Bone Formation Parameters of the Biopsied Ilium Differ between Subtrochanteric and Diaphyseal Atypical Femoral Fractures in Bisphosphonate-Treated Patients.
    Tohoku J Exp Med 2017 ;243(4):247-254
    Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences.
    Atypical femoral fractures (AFFs) are defined as atraumatic or low-trauma fractures located in the subtrochanteric or diaphyseal sites. Long-term bisphosphonates (BPs) are administered to prevent fragility fractures in patients with primary osteoporosis or collagen diseases who are already taking glucocorticoids (GCs). Long-term BP use is one of the most important risk factors for AFFs. Read More

    Transcriptional Survey of Alveolar Macrophages in a Murine Model of Chronic Granulomatous Inflammation Reveals Common Themes with Human Sarcoidosis.
    Am J Physiol Lung Cell Mol Physiol 2017 Dec 6:ajplung.00289.2017. Epub 2017 Dec 6.
    University of Washington
    To advance our understanding of the pathobiology of sarcoidosis, we developed a multiwall carbon nanotube (MWCNT)-based murine model that shows marked histological and inflammatory signal similarities to this disease. In this study, we compared the alveolar macrophage transcriptional signatures of our animal model with human sarcoidosis to identify overlapping molecular programs. Whole-genome microarrays were used to assess gene expression of alveolar macrophages in 6 MWCNT-exposed and 6 control animals. Read More

    PERIVASCULAR GRANULOMATA IN THE RETINA DEMONSTRATED BY EN FACE OPTICAL COHERENCE TOMOGRAPHY IN A PATIENT WITH BLAU SYNDROME.
    Retin Cases Brief Rep 2017 Nov 23. Epub 2017 Nov 23.
    UCLA Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California.
    Purpose: To describe the multimodal retinal imaging findings of a case of Blau syndrome.

    Methods: Case report. The multimodal retinal imaging findings, including widefield angiography, cross-sectional and en face spectral domain optical coherence tomography, and optical coherence tomography angiography, of a case of Blau syndrome are described. Read More

    Feasibility study of a randomised controlled trial to investigate the treatment of sarcoidosis-associated fatigue with methylphenidate (FaST-MP): a study protocol.
    BMJ Open 2017 Dec 4;7(12):e018532. Epub 2017 Dec 4.
    Department of Medicine, University of East Anglia Norwich Medical School, Norwich, Norfolk, UK.
    Introduction: Fatigue is a frequent and troublesome manifestation of chronic sarcoidosis. This symptom can be debilitating and difficult to treat, with poor response to the treatment. Symptomatic management with neurostimulants, such as methylphenidate, is a possible treatment option. Read More

    Urinary 8-Hydroxy-2'-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis.
    Circ Cardiovasc Imaging 2017 Dec;10(12)
    From the Division of Cardiology, Department of Medicine and Clinical Science (H.I., S.K., T.M., M.K., T.N., W.M., S. Oda, K.O., S. Okuda, M.Y.) and Department of Radiology (M.O.), Yamaguchi University Graduate School of Medicine, Ube, Japan; and Department of Radiology, St Hill Hospital, Ube, Japan (K.S.).
    Background: Recently, we reported that urinary 8-hydroxy-2'-deoxyguanosine (U-8-OHdG), an oxidative stress marker, reflected inflammatory activity in cardiac sarcoidosis (CS). Here, we investigated whether U-8-OHdG levels were associated with ventricular tachycardia (VT) in patients with CS.

    Methods And Results: This prospective cohort study enrolled 62 consecutive patients with CS, of whom 36 were diagnosed as having active CS based on abnormal 18F-flurodeoxyglucose accumulation in the heart on positron-emission tomography/computed tomography. Read More

    Autoimmune and medication-induced lymphadenopathies.
    Semin Diagn Pathol 2017 Nov 28. Epub 2017 Nov 28.
    Department of Hematopathology, M.D. Anderson Cancer Center Houston, TX, USA.
    This article will provide a discussion of some common autoimmune disorders that could affect the lymph nodes and potentially mimic B and T-cell lymphomas. Some of these disorders are more characteristic of individuals in the pediatric age group (autoimmune lymphoproliferative syndrome, Kawasaki disease), while others present in older individuals (rheumatoid arthritis, lupus erythematosus, sarcoidosis). A common finding that groups all of these disorders together is the overall relative preservation of the architecture, a feature that can be particularly helpful to distinguish them from many B and T-cell lymphomas. Read More

    Clinical significance of serum anti-GM-CSF autoantibody levels in autoimmune pulmonary alveolar proteinosis.
    Biomark Med 2017 Dec 5. Epub 2017 Dec 5.
    Medical Clinic, Aichi Medical University Hospital, Aichi, Japan.
    Aim: Precise clinical significance of antigranulocyte-macrophage colony stimulating factor (GM-CSF) autoantibody levels in autoimmune pulmonary alveolar proteinosis (aPAP) has not been well studied.

    Methods: We obtained sera from 50 healthy controls, 46 aPAP patients, 50 with sarcoidosis, 52 with idiopathic interstitial pneumonia and 75 with pneumoconiosis. The clinical course of aPAP patients was assessed by scoring computed tomography images in 19 patients. Read More

    The relationship of SSRI and SNRI usage with interstitial lung disease and bronchiectasis in an elderly population: a case-control study.
    Clin Interv Aging 2017 21;12:1977-1984. Epub 2017 Nov 21.
    Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
    Background: The association between interstitial lung disease (ILD) and selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors (SSRI/SNRI) has been previously described in published case reports. However, its prevalence may be more common than expected. We examined the association between SSRI/SNRI usage and presence of ILD and or bronchiectasis (ILD/B) in an elderly population. Read More

    Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials: analysis of 45 cases and comprehensive review of the literature.
    Immunol Res 2017 Dec 3. Epub 2017 Dec 3.
    Europe Medical Centre, Barcelona, Spain.
    Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and methacrylate compounds in a Spanish patient cohort. This study is a retrospective analysis of clinical, laboratory, histopathological and follow-up data of 45 cases of patients suffering from late-onset, non-infectious inflammatory/autoimmune disorders related to bioimplants. Read More

    Which diseases are risk factors for developing gastroesophageal reflux disease?
    Turk J Gastroenterol 2017 12;28(Suppl 1):S44-S47
    Clinic of Gastroenterology, Tekirdağ State Hospital, Tekirdağ, Turkey
    Although the pathophysiology of gastroesophageal reflux disease (GERD) remains unclear, it is accepted as a multifactorial disease. It is thought that some of the interventions that might cause alterations in the normal gastrointestinal tract anatomy and diseases that affect the lower esophageal sphincter, esophageal clearance, and stomach motility (gastric emptying) might lay a foundation for GERD development. Moreover, it is common knowledge that GERD might cause various extraesophageal symptoms and complications. Read More

    Diagnostic Tools to Use When We Suspect an Allergic Reaction to a Tattoo: A Proposal Based on Cases at Our Hospital.
    Actas Dermosifiliogr 2017 Nov 29. Epub 2017 Nov 29.
    Unidad de Alergia Cutánea, Servicio de Dermatología, Hospital General Universitario de Alicante - ISABIAL, Alicante, España.
    Introduction: Tattooing has become a popular practice in western countries, particularly among younger populations. Tattoos, however, can cause complications, such as infections, allergic or foreign-body reactions, and even systemic inflammatory responses.

    Patients And Methods: We conducted a retrospective study of all patients seen for tattoo-related complications at our skin allergy unit between January 2002 and December 2016. Read More

    Verification of Heart Disease: Implications for a New Heart Transplantation Allocation System.
    JACC Heart Fail 2017 Dec;5(12):904-913
    Department of Cardiology, Kaufman Center for Heart Failure, Cleveland, Ohio; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland, Ohio. Electronic address:
    Objectives: This study sought to determine the accuracy of the pre-transplantation clinical diagnosis of heart disease in the United Network for Organ Sharing (UNOS) database.

    Background: Because survival on the heart transplantation waitlist depends on underlying heart disease, a new allocation system will include the type of heart disease. Accuracy of the pre-transplantation clinical diagnosis and the effect of misclassification are unknown. Read More

    Radiological and nuclear medicine imaging of sarcoidosis.
    Q J Nucl Med Mol Imaging 2017 Nov 30. Epub 2017 Nov 30.
    Department of Nuclear Medicine and Molecular Imaging, University Hospitals, Leuven, Belgium.
    Sarcoidosis is a multisystem chronic inflammatory disease of unknown etiology characterized by widespread growth of non-caseating granulomas. The diagnosis of sarcoidosis is based on clinical and imaging presentation, histologic confirmation and the absence of alternative diseases. Radiology and Nuclear Medicine play an essential role in the diagnostic work-up of patients with sarcoidosis to assess disease extent and activity. Read More

    Expression of interleukin-27 (IL-27) in the lower airways diseases. Increased levels of IL-27 in early clinical stages of non-small cell lung cancer (NSCLC) patients.
    Pol Arch Intern Med 2017 Nov 29. Epub 2017 Nov 29.
    INTRODUCTION    Interleukin-27, is a cytokine secreted mostly by antigen presenting cells, key for the Th1 cells immune polarization. Its role in interstitial lung diseases (ILD) as well as in lung cancer has been investigated.  OBJECTIVES    Assessment of IL-27 expression in the lower airways of patients with selected ILD and early-stage non-small cell lung cancer (NSCLC). Read More

    Cutaneous sarcoidosis and secondary open-angle glaucoma in a patient: case report and literature review.
    An Bras Dermatol 2017 May-Jun;92(3):407-409
    Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
    The current report presents the case of a 41-year-old male patient with a two-month history of asthenopia and plaques in the frontotemporal region. Computed tomography revealed bilateral hilar and mediastinal lymphadenopathy. Ophthalmological examination showed elevated intraocular pressure. Read More

    A case of acute kidney injury caused by granulomatous interstitial nephritis associated with sarcoidosis.
    CEN Case Rep 2017 Nov 27. Epub 2017 Nov 27.
    Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan.
    Sarcoidosis affects multiple organs including lung, heart and kidney. Sarcoidosis causes hypercalcemia, hypergammaglobulinemia, and rarely, granulomatous interstitial nephritis, resulting in renal stromal damage. Granulomatous interstitial nephritis is characterized as interstitial nephritis with noncaseating epithelioid granulomas. Read More

    Association between sarcoidosis, pulse wave velocity, and other measures of subclinical atherosclerosis: a systematic review and meta-analysis.
    Clin Rheumatol 2017 Nov 25. Epub 2017 Nov 25.
    Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Chronic inflammation from autoimmune diseases has shown to be a risk factor for atherosclerosis, subsequently leading to cardiovascular disease. Endothelial dysfunction is the early pathogenesis of atherosclerosis in chronic inflammation, but the risk of atherosclerosis in sarcoidosis is less well defined. This meta-analysis aimed to explore the association of subclinical atherosclerosis and arterial stiffness in sarcoidosis. Read More

    High-Cost Sarcoidosis Patients in the United States: Patient Characteristics and Patterns of Health Care Resource Utilization.
    J Manag Care Spec Pharm 2017 Dec 17;23(12):1261-1269. Epub 2017 Oct 17.
    2 Mallinckrodt Pharmaceuticals, Hampton, New Jersey.
    Background: Sarcoidosis is a multisystem inflammatory disorder characterized by the presence of noncaseating granulomas in involved organs. Prior research has found that sarcoidosis imposes a significant economic burden to U.S. Read More

    The Protean Neuropsychiatric and Vestibuloauditory Manifestations of Neurosarcoidosis.
    Audiol Neurootol 2017 Nov 23;22(4-5):205-217. Epub 2017 Nov 23.
    Department of Otolaryngology - Head and Neck Surgery, Northwestern University, Chicago, IL, USA.
    Background: A rare subset of sarcoidosis, neurosarcoidosis, is reported to occur in 5-7% of sarcoid patients and can manifest in a variety of ways. The most common are facial paralysis and optic neuritis, less commonly causing cochleovestibulopathy, blindness, anosmia, and other cranial nerve (CN) palsies. The sensory deficit may be severe and psychiatric symptoms may result from the effects of the disease or steroid treatment. Read More

    The different roles of innate immune receptors in inflammation and carcinogenesis between races.
    Environ Health Prev Med 2017 Oct 11;22(1):70. Epub 2017 Oct 11.
    Department of Public Health and Preventive Medicine, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
    Innate immune factors exert widespread effects on cytokine secretion, cell survival, autophagy, and apoptosis. Nucleotide-binding and oligomerization domain-like receptors (NLRs) are members of the innate immune system in the cytosol that sense pathogens, endogenous danger molecules such as uric acid, and pollutants. Nucleotide-binding oligomerization domain-containing protein 1 and 2 (NOD1 and NOD2) are components of NLR family, and ligands of these factors are γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) and muramyl dipeptide (MDP), respectively. Read More

    Immunology repertoire study of pulmonary sarcoidosis T cells in CD4+, CD8+ PBMC and tissue.
    Oncotarget 2017 Oct 9;8(52):89515-89526. Epub 2017 Aug 9.
    Clinical Medical Research Center, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Luohu District, Shenzhen, China.
    Sarcoidosis is a systemic granulomatous disorder highly related with immune response. The diversity and stability of the immune system could be measured by hypervariable complementarity-determining region 3 (CDR3) segments of the T cell receptor (TCR). Here we used a combination of multiplex PCR and next-generation sequencing to conduct a good quality analysis of the T-cell receptor BV complementarity-determining region 3 (TCR BV CDR3) gene in peripheral blood mononuclear cells (PBMCs) from 7 sarcoidosis patients and lung sarcoidosis tissue from 6 patients. Read More

    [Primary Sjögren syndrome in a child].
    Arch Pediatr 2017 Dec 20;24(12):1249-1252. Epub 2017 Nov 20.
    Service de médecine interne, CHU Hédi Chaker, 3029 Sfax, Tunisie.
    Sjögren syndrome is uncommon in children and occurs most often in association with autoimmune diseases (secondary Sjögren syndrome). We describe the clinical and biological features of a 7-year-old girl with primary Sjögren syndrome revealed by recurrent parotiditis.

    Case Report: A 7-year-old girl was referred for investigation of multiple episodes of parotid swelling since age 4 years, without systemic symptoms. Read More

    Mycobacterium genavense infections in non-HIV immunocompromised hosts: a systematic review.
    Infect Dis (Lond) 2017 Nov 20:1-11. Epub 2017 Nov 20.
    a Division of Infectious Disease, Department of Medicine , Mayo Clinic , Rochester , MN , USA.
    Background: Mycobacterium genavense is a non-tuberculous mycobacterium which can rarely cause disease in non-HIV immunocompromised hosts. We describe our experience with this unusual infection and perform a systematic review of the literature to describe the features of M. genavense infection in non-HIV immunocompromised hosts. Read More

    Small Fiber Neuropathy: Diagnosis, Causes, and Treatment.
    Joint Bone Spine 2017 Nov 15. Epub 2017 Nov 15.
    Département de Médecine Interne, Hôpital Lariboisière, APHP, 75010 Paris France; Université Paris Diderot, 75010 Paris, France. Electronic address:
    Small fiber neuropathy, which affects the sensory A≏ and C fibers, is now a major diagnostic and therapeutic challenge. Nearly 7% of the general population have chronic neuropathic pain responsible for severe quality-of-life impairments. Awareness must therefore be raised among clinicians of the somatosensory and autonomic symptoms that can reveal small fiber neuropathy, appropriate diagnostic investigations, most common causes, and best treatment options for each patient profile. Read More

    Impact of rapid on-site cytological evaluation (ROSE) on the diagnostic yield of transbronchial needle aspiration during mediastinal lymph node sampling: systematic review and meta-analysis.
    Chest 2017 Nov 15. Epub 2017 Nov 15.
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Electronic address:
    Background: Whether the use of rapid onsite cytological evaluation (ROSE) increases the diagnostic yield of transbronchial needle aspiration (TBNA) remains unclear. Herein, we perform a systematic review of studies describing the utility of ROSE in subjects undergoing TBNA.

    Methods: Systematic review of PubMed, EmBase and Scopus databases for RCTs investigating the diagnostic yield of conventional TBNA (c-TBNA) or endobronchial ultrasound (EBUS)-TBNA, with or without ROSE, in subjects with mediastinal lymphadenopathy. Read More

    Right ventricular involvement in cardiac sarcoidosis demonstrated with cardiac magnetic resonance.
    ESC Heart Fail 2017 Nov 6;4(4):535-544. Epub 2017 Jun 6.
    Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
    Aims: Cardiac involvement in sarcoidosis is reported in up to 30% of patients. Left ventricular involvement demonstrated by contrast-enhanced cardiac magnetic resonance has been well validated. We sought to determine the prevalence and distribution of right ventricular late gadolinium enhancement in patients diagnosed with pulmonary sarcoidosis. Read More

    Emergency Radiotherapy for Spinal Cord Compression due to Bone Sarcoidosis.
    Intern Med 2017 Nov 20. Epub 2017 Nov 20.
    Department of Respiratory Medicine, Hirosaki University Graduate School of Medicine, Japan.
    Sarcoidosis is an inflammatory granulomatous disease that is systemic, but bone involvement is uncommon. A 68-year-old man was referred to our hospital complaining of right shoulder pain with numbness. Computed tomography revealed systemic lymphadenopathy and multiple bone lesions. Read More

    Cardiac Sarcoidosis Presenting as Acute Progressive Heart Failure with Abdominal Lymphadenopathy.
    Intern Med 2017 Nov 20. Epub 2017 Nov 20.
    Department of Cardiology, Yamanashi Prefectural Central Hospital, Japan.
    A 77-year-old Japanese woman presented with asymptomatic abdominal lymphadenopathy. Soluble interleukin-2 receptor (sIL2R) and angiotensin-converting enzyme (ACE) levels were elevated, and a pathological examination of lymph-node biopsies revealed non-caseating granulomas, which was consistent with sarcoidosis. Fluorodeoxyglucose-positron emission tomography did not show a clear accumulation in the mediastinal lymph-nodes or heart. Read More

    Comprehensive analysis of vitreous specimens for uveitis classification: a prospective multicentre observational study.
    BMJ Open 2017 Nov 16;7(11):e014549. Epub 2017 Nov 16.
    Department of Ophthalmology and Visual Science, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Purpose: To determine the clinical relevance of vitreous biomarkers in patients with uveitis.

    Design: Multicentre, prospective, observational study.

    Setting: Uveitis outpatient clinics of two academic medical centres in Japan. Read More

    Considerations regarding sarcoidosis in the bariatric surgical patient.
    Surg Obes Relat Dis 2017 Oct 16. Epub 2017 Oct 16.
    Department of Medicine, Division of Pulmonary & Critical Care Medicine, Albany Medical College, Albany, New York.
    The sarcoidosis patient who seeks surgical management for obesity presents many challenges. The interaction between sarcoidosis and obesity complicates both disorders and creates special issues to consider when contemplating surgery. This manuscript will review the approach to pre- and postoperative management of the sarcoidosis patient undergoing bariatric surgery. Read More

    [Ocular sarcoidosis : Diagnosis and therapy].
    Ophthalmologe 2017 Sep;114(9):865-876
    Augenklinik, Campus Virchow-Klinikum, Charité, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland.
    Sarcoidosis is a multisystem disorder of unknown cause. Ophthalmic involvement occurs in up to 60% of all patients, often as the first manifestation of sarcoidosis. Because of the heterogeneous clinical presentation diagnosis can be difficult; therefore the International Workshop on Ocular Sarcoidosis (IWOS 2009) diagnostic criteria based on clinical presentation, laboratory investigations and imaging techniques enable establishment of the diagnosis. Read More

    Sarcoid-like granulomas in renal cell carcinoma: The Houston Methodist Hospital experience.
    Ann Diagn Pathol 2017 Dec 29;31:62-65. Epub 2017 Jul 29.
    Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, United States. Electronic address:
    Sarcoid-like (SL) granulomas have been previously described in association with malignant tumors. These granulomas appear to be tumor-related but are not indicative of systemic sarcoidosis, and hence are referred to as SL reactions. These SL reactions can be seen within the primary tumor, its vicinity, or in uninvolved sites such as the spleen, bone marrow, skin, and/or regional lymph nodes draining the tumor. Read More

    Magnetic resonance elastography: beyond liver fibrosis-a case-based pictorial review.
    Abdom Radiol (NY) 2017 Nov 15. Epub 2017 Nov 15.
    Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic, 200, First Street SW, Rochester, MN, 55905, USA.
    Magnetic resonance elastography (MRE) has been introduced for clinical evaluation of liver fibrosis for nearly a decade. MRE has proven to be a robust and accurate technique for diagnosis and staging of liver fibrosis. As clinical experience with MRE grows, the possible role in evaluation of other diffuse and focal disorders of liver is emerging. Read More

    Fulminant intramedullary spinal cord sarcoidosis.
    Mult Scler Relat Disord 2017 Nov 13;18:47-48. Epub 2017 Sep 13.
    Department of Neurology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address:
    Neurosarcoidosis is a rare disease with various clinical phenotypes. Thus, case reports and series broaden the understanding of this entity (Ibitoye et al., 2017). Read More

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