33,289 results match your criteria Sarcoidosis


A Rare Presentation of Sarcoidosis Masquerading as Colonic Polyps on Screening Colonoscopy.

ACG Case Rep J 2022 Jun 22;9(6):e00800. Epub 2022 Jun 22.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, VA.

Sarcoidosis is a systemic disease characterized by noncaseating granulomatous inflammation. Gastrointestinal involvement in sarcoidosis is a very rare occurrence, with the colon being affected in few patients. We present a case of sarcoidosis presenting as multiple colonic polyps found on routine colorectal cancer screening colonoscopy. Read More

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Giant Lupus Vulgaris with Negative T-SPOT.TB, a Case Report and Literature Review.

Clin Cosmet Investig Dermatol 2022 18;15:1119-1123. Epub 2022 Jun 18.

Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, People's Republic of China.

Lupus vulgaris is a paucibacillary form of cutaneous tuberculosis (CTB) which is accounting for 1-2% of all tuberculosis cases. Here, we report a rare huge lupus vulgaris misdiagnosed as sarcoidosis for 11 years. A 65-year-old man presented to dermatology outpatient with a large asymptomatic erythematous plaque and erosions on his neck. Read More

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Unusual case of cerebral embolism after initiation of selexipag for sarcoidosis-related pulmonary hypertension: a case report.

Radiol Case Rep 2022 Sep 18;17(9):3009-3014. Epub 2022 Jun 18.

Department of Cardiology, Chutoen General Medical Center, Syoubugauraike 1-1, Kakegawa City 436-8555, Japan.

: Pulmonary hypertension is a rare complication of sarcoidosis. The pathogenesis of sarcoidosis-related pulmonary hypertension is multifactorial, and patients with sarcoidosis-related pulmonary hypertension can have variable treatment responses and prognoses. While selexipag (Nippon Shinyaku / Kyoto / Japan) was recently approved in Japan for the treatment of pulmonary hypertension, the risk of cerebral infarction has not been clearly reported. Read More

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September 2022

Characterization of the PF-ILD phenotype in patients with advanced pulmonary sarcoidosis.

Respir Res 2022 Jun 25;23(1):169. Epub 2022 Jun 25.

Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.

Background: Advanced pulmonary sarcoidosis causes significant morbidity and can lead to death. Large trials demonstrated efficacy of antifibrotics in patients with progressive fibrosing interstitial lung diseases (PF-ILD), including a few with sarcoidosis. To date, little is known about this progressive fibrosing phenotype in sarcoidosis. Read More

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Identification of multidimensional phenotypes using cluster analysis in sarcoid uveitis patients.

Am J Ophthalmol 2022 Jun 22. Epub 2022 Jun 22.

Department of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 69004 Lyon, France; University Claude Bernard Lyon 1, Research on Healthcare Performance (RESHAPE), INSERM U1290, Lyon, France.

Purpose: To identify multidimensional phenotypes of sarcoid uveitis patients Design: Retrospective cohort.

Methods: Study Population: Consecutive patients with biopsy-proven, presumed or probable sarcoid uveitis between December 2003 and December 2020 in Lyon.

Observation Procedure: Data were collected from the clinical notes, and consisted in laboratory and imaging findings, systemic treatments and outcome. Read More

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Ageing with Interstitial lung disease: preserving health and well being.

Curr Opin Pulm Med 2022 Jul;28(4):321-336

Exeter Respiratory Institute University of Exeter, Exeter.

Purpose Of Review: Ageing, the accrual of molecular and cellular damage over a lifetime confers progressive physiologic dysfunction of bodily systems, leaving the body in a heightened state of vulnerability to biophysical and psychosocial stressors. The inflection point is frailty which easily leads to disability and death. Interstitial lung disease (ILD) creates biophysical and psychosocial stresses difficult for even optimally fit patients to cope with. Read More

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The influence of age and sex in sarcoidosis.

Curr Opin Pulm Med 2022 Jul;28(4):307-313

Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio.

Purpose Of Review: This review aims to describe how the clinical manifestations of sarcoidosis may be shaped by the effects of sex hormones and by age dependent changes in immune functions and physiology This review is intended to highlight the need to consider the effects of sex and sex in future studies of sarcoidosis.

Recent Findings: The clinical manifestations of sarcoidosis differ based on sex and gender There is emerging evidence that female and male hormones and X-linked genes are important determinants of immune responses to environmental antigens, which has important implications for granuloma formation in the context of sarcoidosis Furthermore, sex hormone levels predictably change throughout adolescence and adulthood, and this occurs in parallel with the onset immune senescence and changes in physiology with advanced age.

Summary: Recent studies indicate that sex and age are important variables shaping the immune response of humans to environmental antigens We posit herein that sex and age are important determinants of sarcoidosis clinical phenotypes Many gaps in our understanding of the roles played by sex and gender in sarcoidosis, and these need to be considered in future studies. Read More

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A Case of Undifferentiated Pleomorphic Sarcoma.

Cureus 2022 Jun 21;14(6):e26153. Epub 2022 Jun 21.

Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.

Suspicion for soft tissue malignancy of the hand is usually low because most tumors of the hand are small and benign. We present a case of an elderly female who presented with a rapidly enlarging, ulcerating hand mass over a few months. She was diagnosed with undifferentiated pleomorphic sarcoma (UPS), a high-grade, aggressive soft-tissue sarcoma. Read More

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The Relationship between Tumor Development and Sarcoidosis in Aspects of Carcinogenesis before and after the Onset of Sarcoidosis.

Medicina (Kaunas) 2022 Jun 6;58(6). Epub 2022 Jun 6.

Gunma University Graduate School of Health Sciences, Maebashi 371-8514, Japan.

: It is still unclear whether sarcoidosis is likely to be associated with tumors. In addition, the use of an immune checkpoint inhibitor has been reported to initiate the onset of sarcoidosis. We retrospectively analyzed tumor development before and after the diagnosis of sarcoidosis and examined the impact of having a history of tumors on the activity or the severity of sarcoidosis. Read More

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Tracking the Molecular Scenarios for Tumorigenic Remodeling of Extracellular Matrix Based on Gene Expression Profiling in Equine Skin Neoplasia Models.

Int J Mol Sci 2022 Jun 10;23(12). Epub 2022 Jun 10.

Department of Animal Molecular Biology, National Research Institute of Animal Production, Krakowska 1 Street, Balice, 32-083 Kraków, Poland.

An important component of tissues is the extracellular matrix (ECM), which not only forms a tissue scaffold, but also provides the environment for numerous biochemical reactions. Its composition is strictly regulated, and any irregularities can result in the development of many diseases, including cancer. Sarcoid is the most common skin cancer in equids. Read More

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Sarcoidosis Mimicking Primary Lung Cancer on Tc-3PRGD2 Scintigraphy in a PTC Patient.

Diagnostics (Basel) 2022 Jun 8;12(6). Epub 2022 Jun 8.

Department of Nuclear Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Sarcoidosis is a multi-system disease of unknown etiology that typically occurs in middle-aged adults, often presenting as the formation of granulomas in various organs, including the lungs. Non-typical pulmonary sarcoidosis is rare, and it isnecessary to distinguish its imaging features from lung cancer and tuberculosis. They may appear as an irregular mass with multiple nodules on thoracic computed tomography (CT). Read More

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Sarcoid-like Granulomatosis Associated with Immune Checkpoint Inhibitors in Melanoma.

Cancers (Basel) 2022 Jun 14;14(12). Epub 2022 Jun 14.

Department of Dermatology, Gustave Roussy, 114 rue Edouard-Vaillant, 94800 Villejuif, France.

We aimed to review the clinical and biological presentation of granulomatosis associated with immune-checkpoint inhibitors (ICI) in patients with melanoma and to explore its association with classical sarcoidosis as well as with cancer response to ICI. To this end, a retrospective study on 18 melanoma patients with histologically proven ICI-induced granulomatosis over a 12-year period in a single center, as well as on 67 similar cases reported in the literature, was conducted. Results indicate ICI-induced granulomatosis is an early side effect (median time to onset: 2 months). Read More

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Integration and application of clinical practice guidelines for the diagnosis of idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis.

Chest 2022 Jun 20. Epub 2022 Jun 20.

Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.

Recent clinical practice guidelines have addressed the diagnosis of idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (fHP). These disease-specific guidelines were developed independently, without clear direction on how to concurrently apply their respective recommendations within a single patient, where discrimination between these two fibrotic interstitial lung diseases represents a frequent diagnostic challenge. The objective of this document, created by an international group of experts, was to suggest a pragmatic approach on how to apply existing guidelines to distinguish IPF and fHP. Read More

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Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review.

Curr Oncol 2022 Jun 7;29(6):4148-4154. Epub 2022 Jun 7.

Medical Oncology Department, Blacktown and Westmead Hospitals, Sydney, NSW 2145, Australia.

Growing teratoma syndrome (GTS) is rare and can mimic disease recurrence in patients with a history of immature teratoma. Benign hypermetabolic lymphadenopathy found on staging and surveillance computed tomography (CT) and positron emission tomography (PET) may lead to the presumption of metastatic malignancy. We report a case of a 38 year old with mixed mature and immature teratomas who developed new peritoneal masses after adjuvant chemotherapy despite a normalization of tumor markers. Read More

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Mammary sarcoidosis: A rare case report.

Ann Med Surg (Lond) 2022 Jun 31;78:103892. Epub 2022 May 31.

Pneumology Department, Moulay Youssef Hospital - Ibn Sina University Hospital, Rabat, Morocco.

Introduction: Sarcoidosis is an inflammatory, systemic, idiopathic disease characterized by multisystem involvement, of which mediastinal and pulmonary involvement is the most frequent. Mammary sarcoidosis is exceptional.

Case Presentation: We report the case of a 50-year-old, diagnosed with mediastinal and mammary sarcoidosis. Read More

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Immune Thrombocytopenic Purpura Secondary to Sarcoidosis.

Maedica (Bucur) 2022 Mar;17(1):234-236

Department of Internal Medicine, Javon Bea Hospital, Rockford, USA.

Sarcoidosis is a systemic granulomatous disease involving multiple organs with predominantly pulmonary manifestations. Severe thrombocytopenia is a relatively rare hematologic manifestation of sarcoidosis. Immune thrombocytopenia is usually characterized by excessive antibody production leading to platelet destruction. Read More

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What cardiologists should know about cardiac sarcoidosis in 2022?

Curr Opin Cardiol 2022 Jul;37(4):380-387

Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec City, Quebec, Canada.

Purpose Of Review: Cardiac sarcoidosis (CS) is a potentially fatal condition when unrecognized or not treated adequately. The purpose of this review is to provide new strategies to increase clinical recognition of CS and to present an updated overview of the immunosuppressive treatments using most recent data published in the last 18 months.

Recent Findings: CS is an increasingly recognized pathology, and its diagnostic is made 20 times more often in the last two decades. Read More

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Clinical features of ocular sarcoidosis: severe, refractory, and prolonged inflammation.

Jpn J Ophthalmol 2022 Jun 21. Epub 2022 Jun 21.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Purpose: To clarify the proportion of ocular sarcoidosis with severe, refractory, and prolonged inflammation and their association with ocular complications and visual prognosis.

Study Design: Multicenter, retrospective, longitudinal cohort study.

Methods: Three hundred and twenty-three eyes of 164 patients (45 men; 119 women) with ocular sarcoidosis who visited Hokkaido University Hospital and Yokohama City University Hospital from 2010 to 2015. Read More

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Dactylitis Due to Subcutaneous Sarcoidosis as a Manifestation of Sarcoidosis.

Actas Dermosifiliogr 2022 Jun 17. Epub 2022 Jun 17.

Servicio de Dermatología, Hospital Universitari de Bellvitge, Universitat de Barcelona, IDIBELL, Barcelona, España.

Dactylitis, or sausage fingers or toes, refers to the swelling of 1 or more digits. Sarcoid dactylitis is an uncommon form that tends to be caused by granulomatous bone involvement in the underlying phalanges. Sarcoid dactylitis can, however, clinically resemble subcutaneous sarcoidosis with finger or toe involvement. Read More

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Atypical and uncommon presentation of sarcoidosis with long segment involvement of the pharynx and larynx: Case report and review of literature.

Radiol Case Rep 2022 Aug 12;17(8):2878-2882. Epub 2022 Jun 12.

Department of Radiology, University of Missouri, Columbia, MO, USA.

Pharynx/Larynx is an uncommon site of involvement of sarcoidosis. Isolated pharyngo-laryngeal sarcoidosis is extremely rare as most of the cases are part from multiorgan and systemic sarcoidosis. Pharyngo-laryngeal sarcoidosis is usually asymptomatic which could be attributed to its rare incidence as many cases pass unnoticed. Read More

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Testicular Sarcoidosis: An Underdiagnosed Manifestation That Poses Unique Challenges.

Cureus 2022 Jun 14;14(6):e25942. Epub 2022 Jun 14.

Internal Medicine/Endocrinology, Our Lady of Lourdes Memorial Hospital, Binghamton, USA.

Testicular involvement is a rarely encountered complication of sarcoidosis. There are unique challenges involved when sarcoidosis affects the genitourinary system. These include differentiating the findings from testicular cancer, which often results in invasive procedures such as orchiectomies. Read More

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Worsening Paraparesis: A Diagnostic Dilemma for Neurosarcoidosis.

Cureus 2022 Jun 15;14(6):e25958. Epub 2022 Jun 15.

Internal Medicine, Guthrie Robert Packer Hospital, Sayre, USA.

Sarcoidosis is a chronic granulomatous disorder mostly known to affect the respiratory system. However, about 5-10% of cases develop neurological complications, either de novo or in patients with known sarcoidosis. The most common complications as cited by current literature include cranial nerve palsies, meningitis, and myelopathy. Read More

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Lesion Localization and Prognosis Using Electrodiagnostic Studies in Facial Diplegia: A Rare Variant of Guillain-Barre Syndrome.

Cureus 2022 May 16;14(5):e25047. Epub 2022 May 16.

Neurology, Aga Khan Health Service, Karachi, PAK.

Background The etiology of facial nerve palsy is diverse and includes herpes zoster virus, Guillain-Barre syndrome (GBS), otitis media, Lyme disease, sarcoidosis, human immunodeficiency virus, etc. The lower motor neuron type facial nerve palsy is usually caused by an ipsilateral facial nerve lesion; however, it may be caused by a central lesion of the facial nerve nucleus and tract in the pons. Facial diplegia is an extremely rare condition that occurs in approximately 0. Read More

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Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation.

Lung 2022 Jun 18. Epub 2022 Jun 18.

Division of Pulmonary, Critical Care and Sleep, College of Medicine-Jacksonville, University of Florida, 655 West 11th Street, Jacksonville, FL, 32209, USA.

Purpose: Alpha-melanocyte stimulating hormone (α-MSH) is known to have anti-inflammatory effects. However, the anti-inflammatory properties of α-MSH on normal bronchial epithelial cells are largely unknown, especially in the context of in vitro sarcoidosis models.

Methods: We evaluated the anti-inflammatory effects of α-MSH on two different in vitro sarcoidosis models (lung-on-membrane model; LOMM and three-dimensional biochip pulmonary sarcoidosis model; 3D-BSGM) generated from NBECs and an in vivo sarcoidosis mouse model. Read More

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Utility of PET/Computed Tomography in Infection and Inflammation Imaging.

PET Clin 2022 Jul;17(3):533-542

Division of Diagnostic Nuclear Medicine, Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address:

The role of nuclear medicine for noninvasive assessment of infection and inflammation is well established. The role of nuclear medicine is limited to initial diagnosis, recurrence, and response assessment of infections and inflammations such as tuberculosis, sarcoidosis, vasculitis, osteomyelitis, immunoglobulin G4-related diseases, and coronavirus disease 2019, as the specificity is affected by false positivity due to physiologic fluorodeoxyglucose uptake in specific organ and nonspecific uptake in postoperative cases. PET with fludeoxyglucose F 18/CT is a well-established modality for diagnosis of fever of unknown origin helping in optimized management of the patient. Read More

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Nonmalignant Thoracic Disorders: An Appraisal of Fluorodeoxyglucose and Non-fluorodeoxyglucose PET/Computed Tomography Applications.

PET Clin 2022 Jul;17(3):495-515

Radiation Medicine Centre (B.A.R.C), Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Mumbai, Maharashtra 400012, India; Homi Bhabha National Institute, 2nd floor, BARC Training School Complex, Anushaktinagar, Mumbai, Maharashtra 400094, India. Electronic address:

PET/computed tomography (CT) with fluorodeoxyglucose and nonfluorodeoxyglucose PET tracers has established itself in the management of malignant disorders. Its role in the assessment of nonmalignant conditions, such as infectious and noninfectious inflammatory diseases and other benign conditions, has emerged independently and alongside its role being evaluated in malignancy and continues to evolve. It is evident that PET/CT has the potential to play a significant role in various nonmalignant disorders of the thorax. Read More

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Effectiveness of methotrexate as a second-line treatment for cardiac sarcoidosis assessed via F-FDG PET: a case report.

Eur Heart J Case Rep 2022 Jun 31;6(6):ytac226. Epub 2022 May 31.

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Background: Although methotrexate has been widely used as a second-line therapy for cardiac sarcoidosis (CS), it is not clear if it has a direct anti-inflammatory effect.

Case Summary: A 65-year-old man presented to our hospital with symptomatic ventricular tachycardia (VT). After cardioversion, electrocardiography showed a first-degree atrioventricular block with a right bundle branch block, and transthoracic echocardiography revealed left ventricular dilatation. Read More

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Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis.

Front Immunol 2022 27;13:895765. Epub 2022 May 27.

Department of Dermatology, Hyogo Medical University, Nishinomiya, Japan.

Blau syndrome is a systemic autoinflammatory granulomatous disease caused by mutations in the nucleotide-binding oligomerization domain 2 () gene. NOD2 is an intracellular pathogen recognition receptor. Upon binding to muramyl dipeptide (MDP), NOD2 activates the NF-κB pathway, leading to the upregulation of proinflammatory cytokines. Read More

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"The Invisible Corset": A Rare Manifestation of Neurosarcoidosis.

Intern Med 2022 Jun 14. Epub 2022 Jun 14.

Department of Neurology, National Hospital Organization Matsumoto Medical Center, Japan.

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