32,127 results match your criteria Sarcoidosis

Disease Behaviour During the Peri-Diagnostic Period in Patients with Suspected Interstitial Lung Disease: The STARLINER Study.

Adv Ther 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Diseases, University Hospital Policlinico "G. Rodolico-San Marco", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.

Introduction: Disease behaviour may guide diagnosis and treatment decisions in patients with interstitial lung disease (ILD). STARLINER aimed to characterise disease behaviour in patients with suspected ILD during the peri-diagnostic period using real-time home-based assessments.

Methods: STARLINER (NCT03261037) was an international, multicentre study. Read More

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Coexistence of immune-mediated diseases in sarcoidosis Frequency and clinical significance in 1737 patients.

Joint Bone Spine 2021 Jun 8:105236. Epub 2021 Jun 8.

Department of Medicine, Universitat de Barcelona, Barcelona, Spain; Department of Autoimmune Diseases, ICMiD, Hospital Clinic, Barcelona, Spain. Electronic address:

Objective: To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease.

Methods: We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population. Read More

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Cardiac sarcoidosis masquerading as arrhythmogenic right ventricular cardiomyopathy: a case report.

Eur Heart J Case Rep 2021 Mar 13;5(3):ytab072. Epub 2021 Mar 13.

Department of Advanced Heart Failure, Sands-Constellation Heart Institute, Rochester Regional Health, 1425 Portland Avenue, Rochester, NY 14621, USA.

Background: Cardiac sarcoidosis (CS) and arrhythmogenic right ventricular cardiomyopathy (ARVC) are rare causes of ventricular arrhythmias and are associated with sudden cardiac death. Differentiation between both is important for proper management.

Case Summary: We present a 56-year-old man with sudden cardiac arrest and was diagnosed to have ARVC based on cardiac magnetic resonance imaging (MRI). Read More

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Utility of nuclear cardiovascular imaging in the cardiac intensive care unit.

J Nucl Cardiol 2021 Jun 9. Epub 2021 Jun 9.

Cleveland Clinic Heart, Thoracic, Institute Cleveland Clinic, 9500 Euclid Ave. J1-5, Cleveland, OH, 44195, USA.

The contemporary Cardiac Intensive Care Unit (CICU) has evolved into a complex unit that admits a heterogeneous mix of patients with a wide range of acute cardiovascular diseases often complicated by multi-organ failure. Although electrocardiography (ECG) and echocardiography are well-established as first-line diagnostic modalities for assessing patients in the CICU, nuclear cardiology imaging has emerged as a useful adjunctive diagnostic modality. The versatility, safety and accuracy of nuclear imaging (e. Read More

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Human U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis.

Sci Rep 2021 Jun 9;11(1):12164. Epub 2021 Jun 9.

Isotope Science Center, The University of Tokyo, Tokyo, Japan.

Acute retinal necrosis (ARN) is a form of infectious uveitis caused by alpha herpesviruses, including herpes simplex virus type 1 (HSV-1). We previously found that the long non-coding RNA (lncRNA) U90926 is upregulated in murine retinal photoreceptor cells following HSV-1 infection, leading to host cell death. However, to date, an orthologous transcript has not been identified in humans. Read More

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Case report of osteolytic lesions in a patient with multisystem granulomatous disease.

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

School of Medicine, University of Notre Dame, Fremantle, Western Australia, Australia.

We present a case of a 70-year-old Caucasian woman with multisystem granulomatous disease involving her lungs, bones and lymph nodes. The patient initially presented with cervical lymphadenopathy and subsequently developed progressive breathlessness. Imaging revealed extensive mediastinal, hilar and intra-abdominal lymphadenopathy as well as bilateral pulmonary parenchymal infiltrates. Read More

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Cesk Slov Oftalmol 2020 ;1(Ahead of print):1-6

Immune mediated inflammatory diseases are categorized into autoimmune and autoinflammatory. Autoimmune etiology is represented by autoreactive lymphocytes or autoantibodies, e.g. Read More

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Adaptive immune system in pulmonary sarcoidosis - comparison of peripheral and alveolar biomarkers.

Clin Exp Immunol 2021 Jun 9. Epub 2021 Jun 9.

Respiratory Diseases and Lung Transplantation, Department of Medical and Surgical Sciences & Neurosciences, Siena University Hospital, Siena, 53100, Italy.

Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Recent research has focused on the role of autoimmunity in its development and progression. This study aimed to determine and define disturbance and distribution of T- and B-cell subsets in the alveolar and peripheral compartments. Read More

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Massive Pulmonary Embolism and Deep Vein Thrombosis in COVID-19 Pneumonia: Two Case Reports.

Cureus 2021 May 4;13(5):e14833. Epub 2021 May 4.

Diagnostic Radiology, St. Joseph Mercy Oakland Hospital, Pontiac, USA.

Coronavirus disease 2019 (COVID-19) is known to cause a severe acute respiratory syndrome with increased morbidity and mortality due to multiorgan involvement. COVID-19 is associated with an increased risk of venous thromboembolism (VTE), ranging from asymptomatic to potentially fatal presentations. Predictors of VTE in COVID-19 are not fully defined, and the role of anticoagulation in these patients is debatable. Read More

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Pulmonary sarcoidosis masquerading as metastatic breast cancer: a case report.

Pan Afr Med J 2021 8;38:245. Epub 2021 Mar 8.

Department of Radiology, Alexis Multispecialty Hospital, Nagpur, Maharashtra, India.

Pulmonary lesions on imaging are presumed to be metastatic lesions in patients with breast cancer. Here, we report an interesting case of a 63-year-old lady with breast carcinoma showing pulmonary lesions on imaging suggestive of pulmonary metastases. Detailed evaluation of pulmonary lesions confirmed the presence of co-existing pulmonary sarcoidosis. Read More

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Georgian Med News 2021 Apr(313):84-88

SO «National Institute of Phthisiology and Pulmonology named after F. G. Yanovsky of National Academy of Medical Sciences of Ukraine», Kyiv, Ukraine.

Long-term outcomes of glucocorticosteroid therapy in pulmonary sarcoidosis patients testify for high rate of relapses, which nowadays are the most acute problem in providing care to these patients. Aim - to study clinical factors, associated with pulmonary sarcoidosis relapse. 108 patients with newly diagnosed pulmonary sarcoidosis were examined (stage II - 102 patients, stage III - 6 patients). Read More

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TNF-α inhibitors used as steroid-sparing maintenance monotherapy in parenchymal CNS sarcoidosis.

J Neurol Neurosurg Psychiatry 2021 Jun 8. Epub 2021 Jun 8.

Service de Neurologie, Hôpital de la Timone, Hôpitaux Universitaires de Marseille, Marseille, France

Objective: To assess the efficacy of tumour necrosis factor-α (TNF-α) inhibitors used as steroid-sparing monotherapy in central nervous system (CNS) parenchymal sarcoidosis.

Methods: The French Multiple Sclerosis and Neuroinflammation Centers retrospectively identified patients with definite or probable CNS sarcoidosis treated with TNF-α inhibitors as steroid-sparing monotherapy. Only patients with CNS parenchymal involvement demonstrated by MRI and imaging follow-up were included. Read More

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A tale of two diseases: Sarcoidosis, COVID-19 and new therapeutic options with dual RAS inhibition and tetanus-diphtheria vaccine.

Demircan Ozbalci

Med Hypotheses 2021 Jun 1;152:110619. Epub 2021 Jun 1.

Suleyman Demirel University School of Medicine, Department of Hematology, Dogu Yerleskesi Cunur, Isparta, Turkey. Electronic address:

Sars Cov-2, the pathogen which belongs to the beta coronavirus family that is responsible for COVID-19, uses Angiotensin Converting Enzyme 2 (ACE2) as a receptor, which is responsible for controlling the actions of renin-angiotensin system (RAS). Sars Cov-2 - ACE2 binding leads to a RAS mediated immune response, which targets especially lungs to form ARDS, which in turn, is the most important cause of mortality in COVID-19. CD8 T cell response dominates over CD4 T cell response and natural killer cell dysfunction also leads to CD4 cell dysfunction in COVID-19; this immune dysregulation leads to inappropriate (ARDS) and inadequate (low or quickly waning antibodies) responses to the disease and unfortunately, prepares the patients for re-infections. Read More

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Overcoming the low yield of histology for the diagnosis of cardiac sarcoidosis.

Int J Cardiol 2021 Jun 5. Epub 2021 Jun 5.

Heart and Lung Center, Helsinki University and Helsinki University Hospital, Helsinki, Finland.

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Sarcoidosis: An Occupational Disease?

Chest 2021 Jun 5. Epub 2021 Jun 5.

The Occupational Health Clinics for Ontario Workers, Sudbury, Ontario, CA; Laurentian University, Sudbury, Ontario, CA; Center for Research in Occupational Safety and Health, Sudbury, Ontario, CA.

Sarcoidosis is an important member of the family of granulomatous lung diseases. Since its recognition in the late 19 century, sarcoidosis has been thought of as a disease of unknown cause. Over the past 20 years this paradigm has been shifting, more rapidly in the past 10 years. Read More

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Fracture of the Dens Axis Due to Spinal Manifestation of Sarcoidosis: Treatment Option and Review of the Literature.

Spine (Phila Pa 1976) 2021 Jul;46(13):E743-E749

Department of Orthopedics, Trauma Surgery and Hand Unit, Helios Klinikum Krefeld, Krefeld, Germany.

Study Design: Case report and literature review.

Objective: We present a case of a pathologic unstable fracture of the odontoid process due to vertebral osseous sarcoidosis. The surgical management of this unreported pathology is described and a review of the literature is given. Read More

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Acute arthritis, skin rash and Lofgren's syndrome.

BMJ Case Rep 2021 Jun 7;14(6). Epub 2021 Jun 7.

Department of Radiotherapy and Oncology, IGMC, Shimla, Himachal Pradesh, India.

Sarcoidosis is an autoimmune multisystem granulomatous disorder of unknown aetiology, which mainly affects the adults in the age group of 20-39 years. The disease can affect any organ in the body but mainly presents as bilateral hilar lymphadenopathy, pulmonary infiltrates, cutaneous lesions, ocular manifestations and arthropathy. Lofgren's syndrome is an uncommon initial presentation of sarcoidosis which is recognised by the classical triad of acute arthritis, erythema nodosum and bilateral hilar lymphadenopathy. Read More

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Sarcoidosis and neuroendocrine tumours: case report and literature review.

Respirol Case Rep 2021 Jul 27;9(7):e00784. Epub 2021 May 27.

Department of Pulmonary Critical Care & Sleep Division Wayne State University Detroit MI USA.

Rare cases of co-existing sarcoidosis and carcinoid tumour have been previously reported in the literature. Both diseases may have vague and overlapping clinical presentations that can lead to delayed or missed diagnosis. To avoid this diagnostic pitfall, we discuss and compare the clinical presentations of all reported cases in the literature including our case. Read More

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A Comprehensive Review of Sarcoidosis Diagnosis and Monitoring for the Pulmonologist.

Pulm Ther 2021 Jun 6. Epub 2021 Jun 6.

UOC Malattie Respiratorie, Dip. Scienze Mediche, Chirurgiche E Neuroscienze Università Di Siena Policlinico "Le Scotte", Siena, Italy.

Sarcoidosis is a systemic granulomatous disease with heterogenous clinical manifestations. Here we review the diagnosis of sarcoidosis and propose a clinically feasible diagnostic work-up and monitoring protocol. As sarcoidosis is a systemic disease, a multidisciplinary approach is recommended for best outcomes. Read More

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Generalised lymphadenopathy in a patient with fever of unknown origin as a differential diagnostic challenge - case report.

J Pak Med Assoc 2021 May;71(5):1489-1492

Department of Infectious diseases, Faculty of Medical Sciences, University of Kragujevac, Serbia.

Fever of unknown origin (FUO) presents a major diagnostic challenge as it is a consequence of many infectious as well as malignant, rheumatologic and other diseases. Here we present the case of a woman with mediastinal and abdominal lymphadenopathy who was initially suspected to have lymphoproliferative disease, but our histopathologic examination revealed sarcoidosis. Sarcoidosis, especially chronic, is a rare cause of FUO, because it usually manifests as a febrile condition. Read More

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Ventricular tachycardia based on cardiac sarcoidosis with a narrow QRS complex, ablated on the left ventricle free-wall.

Indian Pacing Electrophysiol J 2021 Jun 3. Epub 2021 Jun 3.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan; Section of Arrhythmia, Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

A septuagenarian female with cardiac sarcoidosis suffered from drug refractory ventricular tachycardia (VT) requiring multiple implantable cardioverter-defibrillator shocks. The QRS complex during the VT was very similar to that during sinus rhythm although the QRS width during the VT (142 ms) was relatively wider than that during sinus rhythm (107 ms). The VT exit was located on the ventricular septum close to the His-bundle recording region. Read More

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PET/CT Variants and Pitfalls in Breast Cancers.

Semin Nucl Med 2021 Jun 1. Epub 2021 Jun 1.

Department of Radiology, Division of Nuclear Medicine, Cleveland, Ohio; University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, Ohio. Electronic address:

There are a number of normal variants and pitfalls which are important to consider when evaluating F-18 Fluorodeoxyglucose (FDG) with Positron Emission Tomography (PET) in breast cancer patients. Although FDG-PET is not indicated for the initial diagnosis of breast cancer, focally increased glucose metabolism within breast tissue represents a high likelihood for a neoplastic process and requires further evaluation. Focally increased glucose metabolism is not unique to breast cancer. Read More

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The Role of Multimodality Imaging in Cardiac Sarcoidosis.

Korean Circ J 2021 May 10. Epub 2021 May 10.

Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.

The etiology and the progression of sarcoidosis remain unknown. However, cardiac sarcoidosis (CS) is significantly associated with a poor prognosis due to the associated congestive heart failure, arrhythmias (such as an advanced atrioventricular block), and ventricular tachyarrhythmia. Novel imaging modalities are now available to detect CS lesions secondary to active inflammation, granuloma formation, and fibrotic changes. Read More

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Spontaneous epidural hematoma of the cervical spine in two patients with sarcoidosis.

Surg Neurol Int 2021 19;12:168. Epub 2021 Apr 19.

Department of Neurosurgery, University Hospital of Ioannina, Ioannina, Epirus, Greece.

Background: Sarcoidosis is correlated with hematological abnormalities that can result in spontaneous spinal epidural hematomas (EDH). As there is significant risk for permanent neurologic sequelae due to acute cord compression, these lesions often warrant emergent surgical intervention.

Case Description: Two females, 56 and 62 years of age, respectively, both with sarcoidosis on corticosteroids, presented with the spontaneous acute onset of cervical pain, and progressive myeloradiculopathy. Read More

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Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis.

Eur Respir J 2021 Jun 3. Epub 2021 Jun 3.

Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Sarcoidosis is a multisystem granulomatous disease of unknown origin with a variable and often unpredictable course and pattern of organ involvement. In this study we sought to identify specific bronchoalveolar lavage (BAL) cell gene expression patterns indicative of distinct disease phenotypic traits.RNA sequencing by Ion Torrent Proton was performed on BAL cells obtained from 215 well characterised patients with pulmonary sarcoidosis enrolled in the multicenter Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study. Read More

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Systemic Sarcoidosis Induced by Chemotherapy, Mimicking Metastatic Testicular Carcinoma with F-FDG PET/CT

Mol Imaging Radionucl Ther 2021 06;30(2):126-128

University of Health Sciences Turkey, İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey

A 34-year-old male patient who had left orchiectomy and received three cycles of chemotherapy for testicular mix germ cell carcinoma was referred for fluorine-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) for complaints of weight loss and fever. PET/CT showed multiple and progressive F-FDG uptakes in supra and infra diaphragmatic lymphatic regions, and multiple abnormal F-FDG uptakes were noted in the lytic formed skeletal lesions. Clinicians remain in doubt regarding the multiple metastatic lesions without elevated serum tumor marker levels (alpha-fetoprotein, beta-human chorionic gonadotrophin, CA19-9, and carcinoembryonic antigen). Read More

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The challenge of differentiating fibromyalgia from small-fiber neuropathy in clinical practice.

Florian Bailly

Joint Bone Spine 2021 May 31:105232. Epub 2021 May 31.

MD, Hôpital Pitié Salpêtrière - Assistance Publique Hôpitaux de Paris, Rheumatology department, Pain unit ; 47-83 boulevard de l'hôpital, 75013 Paris, France. Electronic address:

Fibromyalgia and small fibre neuropathy are two diseases leading to chronic widespread pain, and it is difficult to differentiate them in order to provide appropriate care. In this review, we will describe the pathophysiological and clinical differences between fibromyalgia and small fibre neuropathy. In fibromyalgia, pain is increased by dysregulation of central pain processing while small fibre neuropathy pain is related to loss or dysfunction of intraepidermal small nerve fibres. Read More

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Non-infectious Dacryoadenitis.

Surv Ophthalmol 2021 May 31. Epub 2021 May 31.

Department of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Dacryoadenitis is an inflammation of the lacrimal gland that may have various etiologies with similar presentations. Despite more recent elucidation of specific causes, the management has remained largely unchanged. Hence, the condition remains under biopsied with the rationale that empirical treatment with corticosteroids is effective for many of the causes. Read More

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Chronic macrocheilia: a clinico-etiological series of 47 cases.

Int J Dermatol 2021 Jun 3. Epub 2021 Jun 3.

Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia.

Background: Macrocheilia is an inflammatory disfiguring condition responsible for the swelling of the lips. This multi-etiological entity represents a diagnostic and therapeutic challenge. Published data on macrocheilia is scarce, often limited to granulomatous cheilitis. Read More

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Bilateral Facial Palsy: A Clinical Approach.

Cureus 2021 Apr 25;13(4):e14671. Epub 2021 Apr 25.

Family Medicine, Schulich School of Medicine & Dentistry, Western University, London, CAN.

Bilateral facial palsy (BFP) is exceedingly rare, representing only 0.3%-2.0% of facial palsy cases. Read More

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