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    A case of sarcoidosis with isolated hepatosplenic onset and development of inflammatory bowel disease during recovery stage.
    Auto Immun Highlights 2017 Dec 28;8(1). Epub 2017 Apr 28.
    Clinica Medica "Cesare Frugoni", Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy.
    Sarcoidosis is a systemic disease characterized by an immune-mediated disorder, which leads to the development of non-caseating granulomas in the involved organs. More than 90% of patients with sarcoidosis present lungs and lymphatic system involvement at onset, while less than 10% has an isolated extrapulmonary localization. Here, we describe the case of an elderly patient with isolated hepato-splenic onset (multiple splenic lesions at imaging and cholestasis), and subsequent pulmonary involvement. Read More

    Intermediate uveitis: pattern of etiology, complications, treatment and outcome in a tertiary academic center.
    Orphanet J Rare Dis 2017 Apr 27;12(1):81. Epub 2017 Apr 27.
    Eye Center, Medical Center, University of Freiburg, Faculty of Medicine, Killianstr. 5, 79106, Freiburg, Germany.
    Background: Patients with intermediate uveitis (IU) represent a heterogenous group characterized by a wide spectrum of etiologies and regional differences. Aim of the study was to analyze the characteristics of patients with IU examined in an academic center in Germany.

    Methods: We conducted a retrospective analysis of the clinical records of all patients with intermediate uveitis referred to the Eye Center, University of Freiburg from 2007 to 2014. Read More

    T1 and T2 Mapping in Recognition of Early Cardiac Involvement in Systemic Sarcoidosis.
    Radiology 2017 Apr 27:162732. Epub 2017 Apr 27.
    From the Department of Cardiology, Guy's and St Thomas' NHS Trust, London, England (V.O.P., A.I., R.H., L.F., G.C., E.N.); Institute of Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Hospital Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany (V.O.P., E.N.); Department of Cardiology, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany (V.O.P.); Department of Cardiovascular Imaging, King's College London, St. Thomas' Hospital, London, England (V.O.P.); Ramón y Cajal University Hospital, University of Alcalá, Madrid, Spain (R.H.); and King's College Hospital NHS Trust, Denmark Hill, London, England (G.C.).
    Purpose To determine whether quantitative tissue characterization with T1 and T2 mapping supports recognition of myocardial involvement in patients with systemic sarcoidosis. Materials and Methods Fifty-three consecutive patients with a biopsy-proven extracardiac diagnosis of systemic sarcoidosis (21 men; median age, 45 years; interquartile range, 22 years) and 36 normotensive previously healthy control subjects (14 men; median age, 43 years; interquartile range, 18 years) underwent cardiovascular magnetic resonance imaging, which was performed to assess cardiac function and late gadolinium enhancement, and T1 and T2 mapping. A follow-up substudy was performed in 40 patients (mean follow-up interval, 144 days ± 35 [standard deviation]); of these 40 patients, 18 underwent anti-inflammatory treatment for systemic symptoms. Read More

    Catheter ablation for ventricular tachycardia in patients with cardiac sarcoidosis: a systematic review.
    Europace 2017 Apr 21. Epub 2017 Apr 21.
    Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.
    Aims: Cardiac sarcoidosis (CS) is associated with a poor prognosis. Important features of CS include heart failure, conduction abnormalities, and ventricular arrhythmias. Ventricular tachycardia (VT) is often refractory to antiarrhythmic drugs (AAD) and immunosuppression. Read More

    Cutaneous Complications Related to Tattoos: 31 Cases from Finland.
    Dermatology 2017 Apr 26. Epub 2017 Apr 26.
    Department of Dermatology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    Background: Cutaneous complications related to permanent tattoos affect 2-30% of those patients who have tattooed their skin. Little is known about the cases of tattoo complications in Finland.

    Objective: The aim of this study was to conduct a retrospective review of a series of Finnish patients with cutaneous tattoo reactions. Read More

    Socioeconomic status and its relationship to chronic respiratory disease.
    Adv Respir Med 2017 ;85(2):97-108
    Northwell Health System Department of Pulmonary, Critical Care and Sleep Medicine The Feinstein Institute for Medical Research Center for Heart and Lung Research Hofstra-Northwell School of Medicine.
    Socioeconomic status (SES) is defined as an individual's social or economic standing, and is a measure of an individual's or family's social or economic position or rank in a social group. It is a composite of several measures including income, education, occupation, location of residence or housing. Studies have found a lower SES has been linked to disproportionate access to health care in many diseases. Read More

    Initial Polish experience of Flexible 19 gauge Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration.
    Adv Respir Med 2017 ;85(2):64-68
    Endoscopy Unit, John Paul II Hospital, Jagiellonian University, Cracow, Poland.
    Introduction: EBUS is a well established minimally invasive diagnostic tool for mediastinal and hilar lymphadenopathy. The novel ViziShot Flex 19G needle (Olympus Respiratory America, Redmond, WA, USA) was introduced in 2015 in order to improve loaded scope flexion and to obtain larger tissue samples for analysis. The aims of this study were to assess diagnostic yield of Flex 19G needles and to present endoscopist's feedback about the endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Read More

    Mistakes in ultrasound diagnosis of superficial lymph nodes.
    J Ultrason 2017 Mar 31;17(68):59-65. Epub 2017 Mar 31.
    Department of Diagnostic Imaging, Medical University of Warsaw, Poland.
    The article discusses basic mistakes that can occur during ultrasound imaging of superficial lymph nodes. Ultrasound is the first imaging method used in the diseases of superficial organs and tissues, including lymph nodes. The causes of mistakes can be either dependent or independent of the performing physician. Read More

    Early and frequent defibrillator discharge in patients with cardiac sarcoidosis compared with patients with idiopathic dilated cardiomyopathy.
    Int J Cardiol 2017 Apr 19. Epub 2017 Apr 19.
    Department of Cardiovascular Medicine, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
    Background: Little is known about the suitability of implantable cardioverter defibrillator (ICD) implantation in patients with cardiac sarcoidosis (CS). We evaluated the efficacy of ICD implantation in patients with CS, including suspected CS, compared with those with idiopathic dilated cardiomyopathy (DCM).

    Methods: A total of 102 consecutive patients with definite CS, suspected CS, or DCM who underwent ICD implantation were enrolled. Read More

    Serious adverse events of cell therapy for respiratory diseases: a systematic review and meta-analysis.
    Oncotarget 2017 Feb 16. Epub 2017 Feb 16.
    Texas Lung Injury Institute, University of Texas Health Northeast, Tyler, Texas, USA.
    Background: Cell therapy holds the most promising for acute and chronic deleterious respiratory diseases. However, the safety and tolerance for lung disorders are controversy.

    Methods: We undertook a systematic review and meta-analyses of all 23 clinical studies of cell therapy. Read More

    Tailored approach for management of ventricular tachycardia in cardiac sarcoidosis.
    J Cardiovasc Electrophysiol 2017 Apr 21. Epub 2017 Apr 21.
    Department Arrhythmia and Electrophysiology Services, CARE Hospital, Banjara Hills, Hyderabad, 500 034, India.
    Introduction: Treating ventricular tachycardia (VT) in patients with cardiac sarcoidosis (CS) is challenging as patients present in different phase of the disease (inflammatory, scar or sometimes both). A customized approach to treatment is required for better outcomes. We describe our experience in the management of VT in CS based on the phase of the disease. Read More

    Dynamic and contrast enhanced CT imaging of lung carcinoma, pulmonary tuberculoma, and inflammatory pseudotumor.
    Eur Rev Med Pharmacol Sci 2017 Apr;21(7):1588-1592
    Medical Image Center, The First People's Hospital of Shangqiu, HeNan, China.
    Objective: Our main aim was to investigate the effect of dynamic and contrast enhanced CT imaging on differential diagnosis of lung carcinoma, pulmonary tuberculoma, inflammatory pseudotumor, and coexisting pulmonary tuberculosis and lung cancer.

    Patients And Methods: About, 144 patients with pulmonary sarcoidosis as the study subjects were chosen which included: 36 patients with lung carcinoma, 36 patients with pulmonary tuberculoma, 36 patients with inflammatory pseudotumor, 36 patients with coexisting pulmonary tuberculosis and lung cancer. CT imaging scan was carried out on all of these 144 patients. Read More

    Appendectomy, tonsillectomy, and risk for sarcoidosis - A hospital-based case-control study in Japan.
    Respir Investig 2017 May 29;55(3):196-202. Epub 2017 Mar 29.
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan. Electronic address:
    Background: The role of surgery in the onset of sarcoidosis is unclear. We investigated whether surgery is an internal environmental factor for sarcoidosis onset within the Japanese population.

    Methods: We enrolled 222 patients diagnosed with sarcoidosis (78 men, 144 women) who were admitted to our department between 1984 and 2012. Read More

    The role of serum amyloid A staining of granulomatous tissues for the diagnosis of sarcoidosis.
    Respir Med 2017 May 8;126:1-8. Epub 2017 Mar 8.
    Division of Pulmonary and Critical Care Medicine, Albany Medical College, Albany, NY, USA. Electronic address:
    Background: Previous studies demonstrated that SAA staining of sarcoidosis granulomas was qualitatively and quantitatively different from other granulomatous diseases. These data suggest that positive SAA staining of granulomatous tissue may have adequate specificity to establish a diagnosis of sarcoidosis. Our objective was to determine the diagnostic specificity of SAA staining for sarcoidosis relative to other granulomatous disorders. Read More

    Initial Experience With Simultaneous 18F-FDG PET/MRI in the Evaluation of Cardiac Sarcoidosis and Myocarditis.
    Clin Nucl Med 2017 Apr 17. Epub 2017 Apr 17.
    From the *Department of Medical Imaging, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada; and †Department of Radiology, and ‡Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, CA.
    Purpose: The purpose of this study was to compare combined PET/MRI with PET/CT and cardiac MRI in the evaluation of cardiac sarcoidosis and myocarditis.

    Methods: Ten patients (4 men and 6 women; 56.1 ± 9. Read More

    Case Report of Sarcoidosis as a Great Mimicker in Various Populations.
    J La State Med Soc 2017 Mar-Apr;169(2):52. Epub 2017 Apr 15.
    Department of Medicine, Leonard J Chabert Medical Center in Houma, LA.
    Introduction: The prevalence of sarcoidosis varies as much as 1-40 cases per 100,000 depending on region and population. Sarcoid typically occurs in people younger than 50 years old, with a peak incidence with ages between 20 and 40 years old. African Americans are 3 times more likely to develop sarcoidosis than Caucasian Americans, and woman are more likely than men to develop sarcoidosis in any ethnic group; nonetheless, it remains a valid differential across any population. Read More

    Not Another ACS Rule Out.
    J La State Med Soc 2017 Mar-Apr;169(2):47. Epub 2017 Apr 15.
    Tulane University School of Medicine, Department of Internal Medicine in New Orleans, LA.
    Case: A 50 year old African-American woman with diabetes, hypertension, and hyperlipidemia presented with progressively worsening retro-sternal chest pain, exacerbated by activity and relieved by rest. She also endorsed a thirty-pound unintentional weight loss, and dysphagia. She was dysarthric with left-sided Bell's Palsy and a palpable left axillary lymph node. Read More

    Rare scar sarcoidosis: A case report.
    Exp Ther Med 2017 Apr 15;13(4):1535-1537. Epub 2017 Feb 15.
    Department of Dermatology, Clinical Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.
    A 70-year-old female patient presenting with swelling and subcutaneous nodule formation localized to the knee scars over a two-month period is presently reported. Dermatological examinations found erythematous swelling and small papules on the patient's knee scars, along with subcutaneous nodules beneath and around the scars. Computer tomography of the chest region identified multiple obscure tubercles in the lungs and swollen lymph nodes in the hilum pulmonis and mediastinum. Read More

    [Pachymeningitis].
    Rev Med Interne 2017 Apr 13. Epub 2017 Apr 13.
    Service de médecine interne, hôpital Saint-Antoine, AP-HP, DHUi2B, université Paris 6, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
    Pachymeningitis is a fibrosing and inflammatory process, which involves the dura mater. Some pachymeningitis are cranial and induce headaches and cranial nerve palsies. Others are spinal and responsible for nerve roots or spinal cord compression. Read More

    [Granulomatous periocular eruption].
    Ann Dermatol Venereol 2017 Apr 11. Epub 2017 Apr 11.
    Clinique universitaire de dermatologie, allergologie et photobiologie, CHU de Grenoble, boulevard de la Chantourne, 38700 La Tronche, France.
    Background: Herein, we report a case of atypical periorificial dermatitis in a patient that had been receiving treatment for some time for atopic dermatitis. The specific feature of this rash was its periocular predominance with no perioral involvement, its clinical aspect and its histological picture evocative of sarcoidosis.

    Patients And Methods: A 33-year-old man was being treated for a atopic dermatitis limited to the face and poorly responsive to dermal corticosteroids. Read More

    [Small fiber neuropathy].
    Rev Med Interne 2017 Apr 11. Epub 2017 Apr 11.
    U1096, service de médecine interne, Normandie univ, UNIROUEN, 76000 Rouen, France.
    Small fiber neuropathy (SFN) is still unknown. Characterised by neuropathic pain, it typically begins by burning feet, but could take many other expression. SFN affects the thinly myelinated Aδ and unmyelinated C-fibers, by an inherited or acquired mechanism, which could lead to paresthesia, thermoalgic disorder or autonomic dysfunction. Read More

    Conventional TBNA experience over a 10-year period: Diagnostic yield and associated limitations in a tertiary care government set-up.
    Indian J Tuberc 2017 Apr 20;64(2):99-103. Epub 2016 Dec 20.
    Junior Resident, Department of Pulmonary Medicine, Government Medical College and Hospital, Sector 32, Chandigarh, India.
    Introduction: It is challenging for pulmonologists to sample mediastinal lymph nodes or some endobronchial lesions because of safety concerns. C-TBNA (conventional transbronchial needle aspiration) is a procedure to sample such sites, but is underutilized. We present a retrospective review of patients subjected to C-TBNA through fibre-optic bronchoscopy over a 10-year period. Read More

    Tracheobroncopathia osteochondroplastica: Three case reports with literature review.
    Niger J Clin Pract 2017 Apr;20(4):495-497
    Department of Pathology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.
    Tracheobroncopathia osteochondroplastica (TO) is a benign disease of the large airways seen very rarely. It is characterized by 1-3 mm sized ossified nodular lesions in submucosa. Its etiology is unclear, but it is stated that malignancy, chronic inflammation, amyloidosis, and genetic factors might have an effect on it. Read More

    [Sarcoidosis : Renal manifestations].
    Z Rheumatol 2017 Apr 12. Epub 2017 Apr 12.
    Medizinische Klinik A, Hämatoonkologie, Nephrologie, Rheumatologie, Klinikum Ludwigshafen, Bremserstr. 79, 67069, Ludwigshafen, Deutschland.
    Renal involvement in sarcoidosis is much more common than generally assumed from old epidemiological studies and is often only detected when actively searched for. Many patients with renal sarcoidosis present with no or only few symptoms. The diagnostic work-up of sarcoidosis should always include a possible renal involvement. Read More

    Diagnosis of sarcoidosis from a biopsy of a dilated mammary duct.
    Proc (Bayl Univ Med Cent) 2017 Apr;30(2):197-199
    Departments of Radiology (Mason, Yang, Hamilton, Shah, Spigel, Wang) and Pathology (Punar), Baylor University Medical Center at Dallas, Texas.
    Sarcoidosis is an immunologic disease of unknown etiology that manifests most frequently within the lungs or associated lymph nodes. Sarcoidosis involving the breast is seen in <1% of cases and usually is diagnosed in patients with multisystem disease. The clinical and imaging presentations of sarcoidosis of the breast can be variable. Read More

    Single-centre experience of granulomatous interstitial nephritis-time for a new approach?
    Clin Kidney J 2017 Apr 7;10(2):249-254. Epub 2017 Jan 7.
    Renal Unit, King's College Hospital, London, UK.
    Background: Differentiating between renal-limited sarcoidosis and tuberculosis (TB) infection as a cause of granulomatous interstitial nephritis (GIN) can be difficult. This series compares clinical features and response to treatment between the different underlying aetiologies in order to propose a management algorithm for GIN to assist with diagnosis and treatment. Methods: This retrospective study reports on all patients presenting with a histological diagnosis of GIN between 2000 and 2012 at our unit. Read More

    Efficacy and safety of tumor necrosis factor antagonists in refractory sarcoidosis: A multicenter study of 132 patients.
    Semin Arthritis Rheum 2017 Mar 8. Epub 2017 Mar 8.
    Service de Médecine Interne, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103 Grande rue de la Croix-Rousse F-69004, Lyon, France; Université Claude Bernard-Lyon 1, Villeurbanne, France. Electronic address:
    Introduction: The off-label use of TNF antagonists in refractory sarcoidosis is increasingly reported but data on their efficacy and safety are still insufficient.

    Objective: To report on efficacy and safety of TNF antagonists in severe and refractory sarcoidosis.

    Methods: Examination of retrospective demographic, clinical, therapeutic, and adverse event data on 132 sarcoidosis patients (58% women; mean (min-max) age = 45. Read More

    [Erythema nodosum : a panniculitis of diverse origins].
    Rev Med Liege 2017 Jan;72(1):43-44
    Service de Dermatologie, CHU de Liège, site du Sart Tilman, Liège, Belgique.
    Erythema nodosum is an acute nodular panniculitis, mainly affecting young women. Diverse etiologies are evoked, but the most frequent are sarcoidosis (Löfgren syndrome), streptococcal infections, yersiniosis and inflammatory enteropathies. Antalgic drugs and rest are usually adequate in this condition, which is spontaneously of favourable evolution. Read More

    An Uncommon Cause of a Small-Bowel Obstruction.
    Case Rep Gastrointest Med 2017 12;2017:1628215. Epub 2017 Mar 12.
    Department of Internal Medicine, Division of Pulmonology, Providence-Providence Park Hospital, Michigan State University College of Human Medicine, Southfield, MI, USA.
    Sarcoidosis is a systemic granulomatous disease of unknown etiology, characterized by the formation of noncaseating granulomas. Gastrointestinal (GI) system involvement that is clinically recognizable occurs in less than 0.9% of patients with sarcoidosis, with data revealing small intestine involvement in 0. Read More

    Thoracic Sarcoidosis: Imaging with High Resolution Computed Tomography.
    J Clin Diagn Res 2017 Feb 1;11(2):TC15-TC18. Epub 2017 Feb 1.
    Assistant Professor, Department of Radiology, Base Hospital , Delhi Cantt, New Delhi, India .
    Introduction: Sarcoidosis is a disease of unknown aetiology that primarily affects the lungs. Clinical and radiological findings with demonstration of non caseating granulomas on pathology is utilised for diagnosing the disease.

    Aim: To assess and evaluate the features of thoracic sarcoidosis on High Resolution Computed Tomography (HRCT) chest. Read More

    Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis: A feasibility study.
    Eur Radiol 2017 Apr 5. Epub 2017 Apr 5.
    Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.
    Objectives: To evaluate the diagnostic value of delayed contrast-enhanced computed tomography (DE-CT) for cardiac sarcoidosis (CS) in patients with or without implantable devices, including a quantitative comparison with late gadolinium enhancement cardiac magnetic resonance (LGE-CMR).

    Methods: Twenty-four patients (mean age, 64 ± 9 years; 17 women) with known or suspected CS underwent retrospective electrocardiogram-gated DE-CT at 80 kV with knowledge-based iterative model reconstruction. Fourteen patients without implantable devices also underwent LGE-CMR, while ten with pacemakers or implantable cardioverter-defibrillators did not. Read More

    A Bare-Bones Approach.
    N Engl J Med 2017 Apr;376(14):1371-1376
    From the Department of Medicine, Legacy Emanuel and Legacy Good Samaritan Hospitals, Portland, OR (K.L., D.J.G.); the Ann Arbor Veterans Affairs (VA) Health Services Research and Development Center of Excellence, the Patient Safety Enhancement Program, University of Michigan Health System, and the Department of Internal Medicine, University of Michigan Medical School - all in Ann Arbor (S.S.); the Department of Medicine and Division of Pulmonary and Critical Care Medicine, Albany Medical College, Albany, NY (M.A.J.); and the Medical Service, San Francisco VA Medical Center, and the Department of Medicine, University of California at San Francisco School of Medicine - both in San Francisco (G.D.).

    [Analysis of an association of TNF -308G>A polymorphism with a risk for pulmonary sarcoidosis in the Russian population of the Republic of Karelia].
    Ter Arkh 2017 ;89(3):61-64
    Petrozavodsk State University, Ministry of Health of Russia, Petrozavodsk, Russia.
    Aim: To analyze an association of TNF -308G>A polymorphism with a risk for pulmonary sarcoidosis (PS) in the Russian population of the Republic of Kareli.

    Subjects And Methods: 84 patients with persistent PS and 96 donors without clinical manifestations of this disease (a control group) were examined. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used to identify alleles and genotypes by the marker of TNF -308G>A polymorphism. Read More

    Magnetic resonance imaging for characterizing myocardial diseases.
    Int J Cardiovasc Imaging 2017 Mar 31. Epub 2017 Mar 31.
    Department of Radiology and Biomedical Imaging, School of Medicine, University of California San Francisco, 185 Berry Street, Suite 350, Campus Box 0946, San Francisco, CA, 94107-5705, USA.
    The National Institute of Health defined cardiomyopathy as diseases of the heart muscle. These myocardial diseases have different etiology, structure and treatment. This review highlights the key imaging features of different myocardial diseases. Read More

    Novel Noninvasive Nuclear Medicine Imaging Techniques for Cardiac Inflammation.
    Curr Cardiovasc Imaging Rep 2017 10;10(2). Epub 2017 Feb 10.
    Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Straße 6, 97080 Würzburg, Germany.
    Purpose Of Review: Inflammation is a key player in a wide range of cardiovascular and myocardial diseases. Given the numerous implications of inflammatory processes in disease initiation and progression, functional imaging modalities including positron emission tomography (PET) represent valuable diagnostic, prognostic, and monitoring tools in patient management. Since increased glucose metabolism is a hallmark of inflammation, PET using the radiolabeled glucose analog [(18)F]-2-deoxy-2-fluoro-d-glucose (FDG) is the mainstay diagnostic test for nuclear imaging of (cardiac) inflammation. Read More

    Hydroxychloroquine-induced hyperpigmentation in systemic diseases: prevalence, clinical features and risk factors: a cross-sectional study of 41 cases.
    Lupus 2017 Jan 1:961203317700486. Epub 2017 Jan 1.
    1 Department of Internal Medicine, Hedi Chaker Hospital, Sfax, Tunisia.
    Introduction Hydroxychloroquine is an antimalarial agent widely prescribed in internal medicine, rheumatology and dermatology. Its use can be complicated by various side effects including skin pigmentation. Objectives The aim of the study is to review epidemiological, clinical features and risk factors of hydroxychloroquine-induced pigmentation. Read More

    Repository corticotropin for Chronic Pulmonary Sarcoidosis.
    Lung 2017 Mar 28. Epub 2017 Mar 28.
    Department of Medicine, University of Cincinnati Medical Center, 1001 Holmes, Eden Ave, Cincinnati, OH, 45267, USA.
    Purpose: The dose of repository corticotropin (RCI) and need for a loading dose in sarcoidosis patients receiving chronic corticosteroids are unclear. We performed a single-blind prospective study, comparing two doses of RCI in sarcoidosis.

    Methods: Chronic pulmonary sarcoidosis patients receiving prednisone therapy with deterioration by 5% in FVC in the previous year were studied. Read More

    Dysphonia - the single symptom of rifampicin resistant laryngeal tuberculosis.
    Open Med (Wars) 2016 26;11(1):63-67. Epub 2016 Mar 26.
    TChildren's Hospital, Affiliate of Vilnius University Hospital Santariskiu Klinikos, Paediatric otolaryngology departament; Santariskiu g. 7, Vilnius 08406, Lithuania.
    Tuberculosis is still the most frequent granulomatous laryngeal disease. Absence of pathognomonic symptoms and change in clinical pattern frequently leads to misdiagnosis and delayed treatment. Hoarseness is the commonest symptom of laryngeal tuberculosis and constitutional symptoms are usually rare. Read More

    P. acnes-Driven Disease Pathology: Current Knowledge and Future Directions.
    Front Cell Infect Microbiol 2017 14;7:81. Epub 2017 Mar 14.
    Department of Biomedical Sciences, NYIT College of Osteopathic Medicine Old Westbury, NY, USA.
    This review discusses the biology and behavior of Propionibacterium acnes (P. acnes), a dominant bacterium species of the skin biogeography thought to be associated with transmission, recurrence and severity of disease. More specifically, we discuss the ability of P. Read More

    Progressive Histoplasmosis with Hemophagocytic Lymphohistiocytosis and Epithelioid Cell Granulomatosis: A Case Report and Review of the Literature.
    Eur J Haematol 2017 Mar 27. Epub 2017 Mar 27.
    Department of Medicine A, University Hospital Muenster, Muenster, Germany.
    Histoplasmosis in central Europe is a rare fungal disease with diverse clinical presentations. Apart from acute pulmonary histoplasmosis and involvement of the central nervous system, the most serious clinical presentation is progressive disseminated histoplasmosis which is generally associated with severe immunodeficiency and in particular, advanced HIV-infection. Here we report on an immunocompetent female residing in a non-endemic area, presenting with progressive disseminated histoplasmosis after a remote travel history to Thailand and Costa Rica. Read More

    Chest Radiographic Screening for Sarcoidosis in the Diagnosis of Patients with Active Uveitis.
    Ann Am Thorac Soc 2017 Mar 27. Epub 2017 Mar 27.
    Erasmus MC, 6993, Ophthalmology, Rotterdam, Zuid-Holland, Netherlands ;
    Rationale: Although chest radiography is currently recommended for the initial evaluation of patients with new onset uveitis, the efficacy of this diagnostic screening modality is not known.

    Objectives: To evaluate the diagnostic value of chest radiographs in patients with active uveitis of recent onset in a tertiary center in Western Europe.

    Methods: A retrospective cross-sectional study was conducted by reviewing all chest imaging for adults with new onset (<1 year) uveitis of unknown origin undergoing initial evaluation in the Department of Ophthalmology at Erasmus University Medical Center (Rotterdam, the Netherlands). Read More

    Incremental Prognostic Value of Global Longitudinal Strain and 18F-Fludeoxyglucose Positron Emission Tomography in Patients With Systemic Sarcoidosis.
    Am J Cardiol 2017 May 1;119(10):1663-1669. Epub 2017 Mar 1.
    Cedars-Sinai Heart Institute, Los Angeles, California. Electronic address:
    In independent studies, abnormal global longitudinal strain (GLS) and myocardial inflammation or scar detected by 18F-fludeoxyglucose positron emission tomography (FDG-PET) are associated with poor prognosis among patients with high likelihood for cardiac sarcoidosis. However, commonly used imaging modalities have not been evaluated in the same population. Our goals were to examine the relation between GLS and FDG-PET, and to evaluate the incremental prognostic value of these imaging techniques for predicting major adverse cardiac events (MACE) in patients suspected to have cardiac sarcoidosis. Read More

    [Analysis of the cellular composition and of the inflammatory response activity in the lymph nodes of patients with sarcoidosis at different stages of the clinical course and treatment with systemic glucocorticosteroids].
    Wiad Lek 2017 ;70(1):32-37
    Вищий Державний Навчальний Заклад України «Українська Медична Стоматологічна Академія», Полтава, Україна.
    Вступ: Вивченню динаміки запальних змін в лімфатичних вузлах хворих саркоїдозом на фоні лікування глюкокориткостероїдами (ГКС) та без них приділяється недостатня увага, що і обумовлює актуальність наукових пошуків у даному напрямку. Мета: Дослідити особливості клітинного складу та активності запальної реакції у лімфатичних вузлах хворих саркоїдозом на різних етапах перебігу та лікування ГКС з урахуванням часу встановлення діагнозу і ступеня активності патології. Матеріали та методи: До аналізу було залучено результати морфологічного дослідження біопсійного материалу, отриманого із уражених лімфатичних вузлів хворих на саркоїдоз. Read More

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