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    Circulating tumor cells and microemboli can differentiate malignant and benign pulmonary lesions.
    J Cancer 2017 15;8(12):2223-2230. Epub 2017 Jul 15.
    Clinical Biochemistry Unit, "Mario Serio" Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
    The presence of circulating tumor cells (CTC) or microemboli (CTM) in the peripheral blood can theoretically anticipate malignancy of solid lesions in a variety of organs. We aimed to preliminarily assess this capability in patients with pulmonary lesions of suspected malignant nature. We used a cell-size filtration method (ScreenCell) and cytomorphometric criteria to detect CTC/CTM in a 3 mL sample of peripheral blood that was taken just before diagnostic percutaneous CT-guided fine needle aspiration (FNA) or core biopsy of the suspicious lung lesion. Read More

    Acute myocarditis secondary to cardiac tuberculosis.
    Echo Res Pract 2017 Aug 16. Epub 2017 Aug 16.
    Cowley A, Department of Cardiology, Leeds General Infirmary, Leeds, UK.
    Isolated myocardial involvement in tuberculosis is exceedingly rare but there are reports it can present with sudden cardiac death, atrioventricular block, ventricular arrhythmias or congestive cardiac failure. We report the case of a 33 year-old male, of South Asian descent, who presented with chest pain, shortness of breath and an abnormal ECG. The patient had no significant past medical history and coronary angiogram showed no evidence of coronary artery disease. Read More

    Seminoma and sarcoid: A confusing collision.
    J Clin Oncol 2012 Feb;30(5_suppl):339
    Department of Medical Oncology, Mercy University Hospitals, Cork, Ireland; Department of Respiratory Medicine, Mercy University Hospital, Cork, Ireland; Department of Histopathology, Mercy University Hospitals, Cork, Ireland; Department of Radiology, Mercy University Hospital, Cork, Ireland; Department of Respiratory Medicine, Cork University Hospital, Cork, Ireland; Mercy University Hospital, Cork, Ireland.
    339 Background: In patients with active or prior malignancy, the presence of mediastinal lymphadenopathy is often assumed to indicate metastases. However, sarcoidosis can imitate malignancy on CT and PET imaging. The incidence of sarcoidosis or "sarcoid-like reaction" in cancer patients (especially testicular germ cell tumor patients) appears to be higher than in the general population. Read More

    A Circulating Micro-RNA Signature Serves as a Diagnostic and Prognostic Indicator in Sarcoidosis.
    Am J Respir Cell Mol Biol 2017 Aug 16. Epub 2017 Aug 16.
    University of Illinois at Chicago, Department of Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy, Chicago, Illinois, United States.
    Micro-RNAs (miRNAs) act as post-transcriptional regulators of gene expression. In sarcoidosis, aberrant miRNA expression may enhance immune responses mounted against an unknown antigenic agent. We tested whether a distinct miRNA signature functions as a diagnostic biomarker and explored its role as an immune modulator in sarcoidosis. Read More

    Palpitations as a presenting feature of multisystem sarcoidosis.
    J Community Hosp Intern Med Perspect 2017 Jul 13;7(3):190-193. Epub 2017 Jul 13.
    Department of Internal Medicine, Easton Hospital, Drexel University Affiliate, Easton, PA, USA.
    Introduction: Sarcoidosis is described as a systemic condition characterized by non-caseating granulomas in multiple organs. In this report, we present an unusual manifestation of cardiac sarcoidosis and review management strategies. Case presentation: A 29-year-old African-American man presented with weight loss, fatigue, dyspnea, palpitations, night sweats, painless left eye redness and bilateral leg pain over the course of three months. Read More

    Association of anxiety sensitivity-physical concerns and FVC with dyspnea severity in sarcoidosis.
    Gen Hosp Psychiatry 2017 Jul 2;47:43-47. Epub 2017 May 2.
    Department of Internal Medicine, Pneumonology and Allergology, Medical University of Warsaw, Zwirki i Wigury 61, 00-001 Warsaw, Poland.
    Objective: The purpose of the study was to evaluate the relationship of an objective functional lung parameter (FVC) and a subjective psychological factor (physical symptom concerns) with dyspnea in sarcoidosis. Dyspnea constitutes one of the most common and burdensome symptoms in sarcoidosis, yet little is known about its mechanisms and, in particular, psychological.

    Method: A total of 107 hospitalized sarcoidosis patients (Female=50, Mage=45. Read More

    Tubulointerstitial nephritis and uveitis.
    Curr Opin Ophthalmol 2017 Aug 12. Epub 2017 Aug 12.
    Department of Ophthalmology, University of Washington, Seattle, Washington, USA.
    Purpose Of Review: Tubulointerstitial nephritis and uveitis (TINU) is an important yet underrecognized ocular inflammatory syndrome. This review summarizes key historical publications that identified and defined the syndrome, and more recent literature that reveal the importance of urinary β2-microglobulin testing and kidney biopsy in the diagnostic evaluation of patients with TINU. Additionally, research studies providing new insights into disease pathogenesis are highlighted. Read More

    Predominance of Comorbidities in the Detriment of Daily Activity in Sarcoidosis Patients.
    Adv Exp Med Biol 2017 Aug 15. Epub 2017 Aug 15.
    School of Medicine with the Division of Dentistry, Department of Lung Diseases and Tuberculosis, Medical University of Silesia, 1 Koziołka Street, 41-803, Zabrze, Poland.
    Sarcoidosis may affect lung function, working ability, overall mobility, and daily activity. In the present study we performed an analysis of clinical settings in patients with sarcoidosis to disentangle its influence on daily physical activity (PA). PA assessment (number of steps per day, daily energy expenditure) was performed by accelerometry during consecutive 7 days after discharge from hospital. Read More

    Abridged version of the AWMF guideline for the medical clinical diagnostics of indoor mould exposure: S2K Guideline of the German Society of Hygiene, Environmental Medicine and Preventive Medicine (GHUP) in collaboration with the German Association of Allergists (AeDA), the German Society of Dermatology (DDG), the German Society for Allergology and Clinical Immunology (DGAKI), the German Society for Occupational and Environmental Medicine (DGAUM), the German Society for Hospital Hygiene (DGKH), the German Society for Pneumology and Respiratory Medicine (DGP), the German Mycological Society (DMykG), the Society for Pediatric Allergology and Environmental Medicine (GPA), the German Federal Association of Pediatric Pneumology (BAPP), and the Austrian Society for Medical Mycology (ÖGMM).
    Allergo J Int 2017 28;26(5):168-193. Epub 2017 Feb 28.
    Department of Infection Control and Environmental Hygiene, Cologne Health Authority, Neumarkt 15-21, 50667 Cologne, Germany.
    This article is an abridged version of the AWMF mould guideline "Medical clinical diagnostics of indoor mould exposure" presented in April 2016 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, GHUP), in collaboration with the above-mentioned scientific medical societies, German and Austrian societies, medical associations and experts. Indoor mould growth is a potential health risk, even if a quantitative and/or causal relationship between the occurrence of individual mould species and health problems has yet to be established. Apart from allergic bronchopulmonary aspergillosis (ABPA) and mould-caused mycoses, only sufficient evidence for an association between moisture/mould damage and the following health effects has been established: allergic respiratory disease, asthma (manifestation, progression and exacerbation), allergic rhinitis, hypersensitivity pneumonitis (extrinsic allergic alveolitis), and increased likelihood of respiratory infections/bronchitis. Read More

    Conditions Simulating Primary Bone Neoplasms.
    Surg Pathol Clin 2017 Sep;10(3):731-748
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Hilton 11, 200 First Street South West Rochester, MN 55905, Rochester, MN, USA. Electronic address:
    A number of nonneoplastic conditions can mimic tumors of bone. Some of the more common mimics of primary bone tumors include infectious, inflammatory, periosteal, and degenerative joint disease-associated lesions that produce tumorlike bone surface-based or intraosseous lesions. This article considers a spectrum of reactive and nonreactive processes including stress fracture, subchondral cysts, osteonecrosis, heterotopic ossification, osteomyelitis, sarcoidosis, and amyloidoma that can present in such a way that they are mistaken for a tumor arising primary in bone. Read More

    Acquired anhidrosis associated with systemic sarcoidosis: Quantification of nerve fibers around eccrine glands by confocal microscopy.
    Br J Dermatol 2017 Aug 10. Epub 2017 Aug 10.
    Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
    Neurological disorders can cause hypohidrosis and/or anhidrosis by disturbing either the central or the peripheral nervous systems.(1-3) Although a syringotropic variant of cutaneous sarcoidosis causes dysfunction of sweating, systemic sarcoidosis rarely causes hypohidrosis or anhidrosis.(4,5) Here we present a novel case of an acquired anhidrosis in a patient with systemic sarcoidosis. Read More

    Incidental extravascular findings in computed tomographic angiography for planning or monitoring endovascular aortic aneurysm repair: Smoker patients, increased lung cancer prevalence?
    World J Radiol 2017 Jul;9(7):304-311
    Maria Antonietta Mazzei, Susanna Guerrini, Francesco Gentili, Luca Volterrani, Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy.
    Aim: To validate the feasibility of high resolution computed tomography (HRCT) of the lung prior to computed tomography angiography (CTA) in assessing incidental thoracic findings during endovascular aortic aneurysm repair (EVAR) planning or follow-up.

    Methods: We conducted a retrospective study among 181 patients (143 men, mean age 71 years, range 50-94) referred to our centre for CTA EVAR planning or follow-up. HRCT and CTA were performed before or after 1 or 12 mo respectively to EVAR in all patients. Read More

    The role of mediastinoscopy in the diagnosis of non-lung cancer diseases.
    Ther Clin Risk Manag 2017 27;13:939-943. Epub 2017 Jul 27.
    Department of Thoracic Surgery, Faculty of Medicine, Dicle University.
    Background: Mediastinoscopy is a good method to evaluate mediastinal lesions. We sought to determine the current role of mediastinoscopy in the investigation of non-lung cancer patients with mediastinal lymphadenopathy.

    Materials And Methods: We retrospectively reviewed clinical parameters (age, gender, histological diagnosis, morbidity, mortality) of all patients without lung cancer who consecutively underwent mediastinoscopy in Hospital of Faculty of Medicine of Dicle University between June 2003 and December 2016. Read More

    Differential diagnosis of granulomatous lung disease: clues and pitfalls: Number 4 in the Series "Pathology for the clinician" Edited by Peter Dorfmüller and Alberto Cavazza.
    Eur Respir Rev 2017 Sep 9;26(145). Epub 2017 Aug 9.
    Interstitial and Rare Lung Disease Unit, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany
    Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomatous lung diseases. Differential diagnosis is challenging, and includes both infectious (mycobacteria and fungi) and noninfectious lung diseases (sarcoidosis, necrotising sarcoid granulomatosis, hypersensitivity pneumonitis, hot tub lung, berylliosis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, rheumatoid nodules, talc granulomatosis, Langerhans cell histiocytosis and bronchocentric granulomatosis). Read More

    Increased Risk of Atherosclerosis in Patients with Sarcoidosis.
    Pathobiology 2017 Aug 10. Epub 2017 Aug 10.
    Section of Respiratory Medicine, Department of Clinical and Experimental Medicine, Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy.
    Sarcoidosis is a systemic granulomatous disease of unknown etiology. Recent studies demonstrated that its pathogenesis is related with enhanced oxidative stress (protein carbonylation and lipid peroxidation) and alterations in the circulating lipid profile. Alterations of lipid metabolism (including the reduction in high-density lipoprotein cholesterol levels and apolipoprotein A1 concentrations) induce plasma membrane, bronchial and lung capillary endothelial cell damage in sarcoidosis patients. Read More

    Sarcoidosis with Takayasu arteritis: a model of overlapping granulomatosis. A report of seven cases and literature review.
    Int J Rheum Dis 2017 Aug 8. Epub 2017 Aug 8.
    Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
    Objective: To describe the features of exceptional coexisting Takayasu arteritis (TA) and sarcoidosis, two conditions of unknown cause associated with a common immunologic pattern.

    Methods: We report seven cases of concomitant sarcoidosis-Takayasu or Takayasu-like vasculitis, observed in two referral centers between 1995 and 2015.

    Results: All patients were female. Read More

    Cavitary lung lesions: Melioidosis and pulmonary embolism causing necrotizing pneumonia.
    IDCases 2017 20;10:4-6. Epub 2017 Jul 20.
    Department of Internal Medicine, Health campus, Universiti Sains Malaysia, Kelantan, Malaysia.
    Cavitary lung lesions of various etiologies may be encountered in patients with respiratory symptoms associated with fever. Non-malignant cavitary lesions may mimic malignant lung lesions on most of radiographic modalities including chest radiographs or thoracic computed tomography (CT). Primary lung malignancy can be detected in as high as one-fifths of CT thorax as cavitary lesions and the remaining aetiologies may be due to bacterial, parasitic, and invasive fungal infections, as well as Granulomatosis with polyangiitis (GPA), sarcoidosis, septic thrombo-embolism, and lung metastasis from extra-pulmonary primaries. Read More

    A curious case of growth failure and hypercalcemia: Answers.
    Pediatr Nephrol 2017 Aug 7. Epub 2017 Aug 7.
    Division of Nephrology, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
    Background: Sarcoidosis is a multisystem granulomatous disease of unknown etiology that rarely presents in childhood. Here, we report a case of pediatric sarcoidosis, presenting with renal failure and hypercalcemia.

    Case Diagnosis/treatment: A previously well 14-year-old Caucasian boy was admitted to the Hospital for Sick Children, Canada, for hypertension and renal failure following work-up by his family physician for initial concerns of growth failure. Read More

    A curious case of growth failure and hypercalcemia: Questions.
    Pediatr Nephrol 2017 Aug 7. Epub 2017 Aug 7.
    Division of Nephrology, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
    Background: Sarcoidosis is a multisystem granulomatous disease of unknown etiology that rarely presents in childhood. Here, we report a case of pediatric sarcoidosis presenting with renal failure and hypercalcemia.

    Case Diagnosis/treatment: A previously well 14-year-old Caucasian boy was admitted to the Hospital for Sick Children, Canada, for hypertension and renal failure following work-up by his family physician for initial concerns of growth failure. Read More

    Systemic Sarcoidosis with Thyroid Involvement.
    Intern Med 2017 Aug 1;56(16):2181-2186. Epub 2017 Aug 1.
    Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Japan.
    A 66-year-old woman, who was diagnosed with iritis, visited our hospital due to general malaise. A blood analysis revealed hypercalcemia. Computed tomography revealed mediastinal and hilar lymph node hyperplasia. Read More

    Granulomas within renal epithelial neoplasms in patients with sarcoidosis: A causal association?
    Pathol Res Pract 2017 Jul 23. Epub 2017 Jul 23.
    Surgical Pathology Division, Department of Pathology, University of Illinois at Chicago, 840 S. Wood St., Suite 130 CSN, Chicago, IL, 60612, United States; Hematologic Pathology Division, Department of Pathology, University of Illinois at Chicago, 840 S. Wood St., Suite 130 CSN, Chicago, IL, 60612, United States.
    Sarcoidosis is a chronic granulomatous disease that can involve virtually every organ system, but most commonly presents as lung, skin, or lymph node disease. Although kidney involvement is usually clinically silent, granulomatous interstitial nephritis - the hallmark of renal sarcoidosis - can lead to functional impairment and organ failure. Also, recent studies have suggested an association between sarcoidosis and an increased risk of developing kidney tumors. Read More

    Cancer and Autoimmune Diseases.
    Autoimmun Rev 2017 Aug 1. Epub 2017 Aug 1.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty in Medicine, Sheba Medical Center, Tel-Aviv University, Israel.
    Purpose Of Review: The association between autoimmunity and cancer is well established. Cancer has been implicated in some autoimmune disorders (AID), such as scleroderma and myositis. On the other hand, many autoimmune disorders and immunosuppressive therapy, have been linked to an increased risk for cancer. Read More

    Jaccoud's arthropathy, an unusual manifestation of idiopathic retroperitoneal fibrosis: rapid improvement of symptoms after tocilizumab treatment.
    Reumatismo 2017 Aug 3;69(2):88-91. Epub 2017 Aug 3.
    Rheumatology Unit, San Giovanni di Dio Hospital, Florence.
    Jaccoud's arthropathy (JA) is a chronic, non erosive, rheumatoid-like deformity associated with rheumatic fever (RF) and systemic lupus erythematosus and with other diseases such as psoriatic arthritis, connective tissue diseases, hypocomplementemic urticarial vasculitis, infections, sarcoidosis and neoplasia. We described a case of JA in a patient with cutaneous psoriasis but with a particular disease evolution associated with idiopathic retropritoneal fibrosis (IRF), evaluated with computed tomography, magnetic resonance and 18F-FDG PET/ CT. The patient, following failure with steroids, methotrexate and etanercept, was treated with tocilizumab (8 mg/kg) once every 4 weeks for 6 months. Read More

    Development of Hodgkin lymphoma in a patient with sarcoidosis.
    Reumatismo 2017 Aug 3;69(2):84-87. Epub 2017 Aug 3.
    Department of Hematology, Katip Celebi University, Ataturk Education and Research Hospital, Izmir.
    Sarcoidosis is a chronic granulomatous disease of unknown etiology characterized by non-caseified granulomas in many different organs and systems. The disease most frequently manifests with bilateral hilar lymphadenopathy and infiltrations in the lungs and skin, as well as with eye lesions. It may mimic a number of systemic diseases and/or accompany them. Read More

    Granulomas in the gastrointestinal tract: deciphering the Pandora's box.
    Virchows Arch 2017 Aug 4. Epub 2017 Aug 4.
    School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.
    Granulomas are organised collection of activated histiocytes induced by a persistent antigen stimulus. A wide variety of antigens encountered by the gastrointestinal tract are of this nature and hence the resulting granulomatous inflammation represents a tissue reaction pattern. The potential causes can be broadly classified as infections or non-infectious immune reactions. Read More

    I Can Not Wear My Sunglasses: An Unusual Sarcoidosis Presentation.
    Korean J Fam Med 2017 Jul 20;38(4):226-228. Epub 2017 Jul 20.
    Department of Internal Medicine Unit, University Hospital Salamanca, Salamanca, Spain.
    A 39-year-old Caucasian man was referred to University Hospital Salamanca from a primary care unit due to the presence of an erythematous violaceous nodule at the superior portion of his nose. Physical examination indicated that the firm, fixed erythematous violaceous nodule measured approximately 2 cm in diameter and was located inferior to a scar on the nasal bridge. Cutaneous involvement in sarcoidosis occurs in 25% of cases. Read More

    The necessity of external validation in exhaled breath research: a case study of sarcoidosis.
    J Breath Res 2017 Aug 4. Epub 2017 Aug 4.
    Department of Pharmacology & Toxicology, Maastricht University NUTRIM School for Nutrition Toxicology and Metabolism, Maastricht, Limburg, NETHERLANDS.
    As in other disciplines of 'omics' research, reproducibility is a major problem in exhaled breath research. Many studies report discriminatory volatiles in the same disease, yet the similarity between lists of identified compounds is low. This can occur due to many factors including the lack of internal and in particular external validation. Read More

    Prevalence and incidence of interstitial lung diseases in a multi-ethnic county of Greater Paris.
    Eur Respir J 2017 Aug 3;50(2). Epub 2017 Aug 3.
    Assistance Publique - Hôpitaux de Paris, Service de Pneumologie, Hôpital Avicenne, Bobigny, France
    The objective of the study was to estimate the prevalence and incidence of interstitial lung diseases (ILDs) in Seine-Saint-Denis, a multi-ethnic county of Greater Paris, France.Patients with ILDs were identified between January and December 2012 by using several sources; all potentially involved medical specialists from public and private hospitals, community-based pulmonologists and general practitioners, and the Social Security system. Diagnoses were validated centrally by an expert multidisciplinary discussion. Read More

    Spectrum of interstitial lung disease from a tertiary care hospital in Karachi.
    J Pak Med Assoc 2017 Jul;67(7):1065-1069
    Aga Khan University, Karachi.
    Objective: To determine the clinical features and patterns of interstitial lung disease.

    Methods: This retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised record of patients diagnosed with interstitial lung disease from January 2005 to December 2015. All patients aged 16 years and above diagnosed with interstitial lung disease on the basis of clinical features, radiological features on high-resolution computed tomography of the chest, and lung biopsies were included. Read More

    Timing of onset affects arthritis presentation pattern in antisyntethase syndrome.
    Clin Exp Rheumatol 2017 Jul 26. Epub 2017 Jul 26.
    Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy.
    Objectives: To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD).

    Methods: The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). Read More

    Multicentric Reticulohistiocytosis with Dermatomyositis-like Eruptions.
    Intern Med 2017 1;56(15):2063-2066. Epub 2017 Aug 1.
    Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Japan.
    A 68-year-old man presented with polyarthritis, proximal muscle weakness, and erythema of the face, arms, neck, and anterior chest that resembled the V-neck sign. Initially, dermatomyositis (DM) was considered because of the erythema, polyarthritis, and muscle weakness. He also had mediastinal and hilar lymphadenopathy on contrast-enhanced computed tomography. Read More

    Paraneoplastic Sarcoidosis in Multiple Myeloma.
    Intern Med 2017 1;56(15):2049-2051. Epub 2017 Aug 1.
    Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan.
    Sarcoidosis predominantly affects the lungs, intrathoracic lymph nodes, and eyes; it less frequently affects the musculoskeletal system. We herein report a case of paraneoplastic sarcoidosis in a patient presenting with multiple myeloma. The patient developed ocular sarcoidosis and showed an increased (18)F-fluorodeoxyglucose uptake in the mediastinal lymph nodes and vertebral column. Read More

    Clinical Features of Pulmonary Sarcoidosis Complicated by Lung Cancer.
    Intern Med 2017 1;56(15):1957-1960. Epub 2017 Aug 1.
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.
    Objective For lung cancer complicated with sarcoidosis, there are no exact features that indicate whether lymphadenopathy is metastatic. This makes the validity of surgery uncertain for clinicians. The aim of this study was to clarify the clinical features of pulmonary sarcoidosis complicated by lung cancer, especially from the viewpoint of evaluating lymphadenopathy. Read More

    Human lung injury following exposure to humic substances and humic-like substances.
    Environ Geochem Health 2017 Aug 1. Epub 2017 Aug 1.
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC, USA.
    Among the myriad particles the human respiratory tract is exposed to, a significant number are distinctive in that they include humic substances (HS) and humic-like substances (HULIS) as organic components. HS are heterogeneous, amorphous, organic materials which are ubiquitous occurring in all terrestrial and aqueous environments. HULIS are a complex class of organic, macromolecular compounds initially extracted from atmospheric aerosol particles which share some features with HS including an aromatic, polyacidic nature. Read More

    Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states.
    Clin Exp Gastroenterol 2017 17;10:147-168. Epub 2017 Jul 17.
    Research Service, Veterans Affairs Medical Center, Minneapolis, MN, USA.
    Protein losing enteropathy (PLE) has been associated with more than 60 different conditions, including nearly all gastrointestinal diseases (Crohn's disease, celiac, Whipple's, intestinal infections, and so on) and a large number of non-gut conditions (cardiac and liver disease, lupus, sarcoidosis, and so on). This review presents the first attempt to quantitatively understand the magnitude of the PLE in relation to the associated pathology for three different disease categories: 1) increased lymphatic pressure (e.g. Read More

    Ophthalmic and neuro-ophthalmic manifestations of sarcoidosis.
    Curr Opin Ophthalmol 2017 Jul 28. Epub 2017 Jul 28.
    aDepartment of Ophthalmology bDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
    Purpose Of Review: Sarcoidosis is a multisystemic inflammatory disease that commonly affects the eye and less often the neuro-ophthalmic pathways. The manifestations can be quite variable but can have characteristic signs and clinical features. This review provides a comprehensive overview of the various ocular and neuro-ophthalmic manifestations of sarcoidosis, emerging diagnostic measures and approach to treatment. Read More

    Necrotizing sarcoid granulomatosis: A distinctive form of pulmonary granulomatous disease.
    Clin Respir J 2017 Jul 29. Epub 2017 Jul 29.
    Department of Pneumonology, Democritus University of Thrace, Alexandroupolis, Greece.
    Objectives: To define the characteristics of necrotizing sarcoid granulomatosis (NGS) a very rare pulmonary disease hardly recognised by pulmonologists and pathologists.

    Data Source: PubMed was searched for the term necrotising or necrotizing sarcoid granulomatosis.

    Study Selection: All cases reported in the English literature were included. Read More

    Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and sarcoidosis: more pathological findings in the same chest CT, or a single pathological pathway?
    BMC Pulm Med 2017 Jul 28;17(1):107. Epub 2017 Jul 28.
    Respiratory Unit, Ospedale San Paolo, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
    Background: Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome, lymphangioleiomyomatosis/tuberous sclerosis complex (LAM-TSC), and sarcoidosis are three rare diseases. Here we present, to the best of our knowledge, the first description of a patient with the coexistence of these three diseases.

    Case Presentation: A 47-year-old woman affected by LAM-TSC and primary biliary cirrosis/autoimmune hepatitis overlap syndrome. Read More

    Cardiac sarcoidosis diagnosed by multimodality imaging.
    Echocardiography 2017 Jul 28. Epub 2017 Jul 28.
    Division of Cardiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.
    A 66-year-old woman presented with frequent premature ventricular contractions (PVC) and akinesis of the basal septum on echocardiography. Coronary angiography was normal. Cardiac magnetic resonance showed mid-wall enhancement. Read More

    Search for biomarkers of neurosarcoidosis by proteomic analysis of cerebrospinal fluid.
    Ann Biol Clin (Paris) 2017 Aug;75(4):393-402
    Service de biochimie. Pôle de biologie médicale et pathologie, Hôpitaux universitaires de l'Est parisien, Hôpital Saint-Antoine, Paris, France, Plate-forme Trans-Prot, IFR 141-IPSIT. UFR de pharmacie, Université Paris-Sud/Paris-Saclay, Châtenay-Malabry, France.
    Sarcoidosis is a systemic granulomatous disease, which mostly affects lung. Central nervous system can be affected causing a neurosarcoidosis in 5 to 15% of all sarcoidosis patients. The definitive diagnosis is established on histological examination of brain granulomas. Read More

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