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    A comparative study on inflammatory factors and immune functions of lung cancer and pulmonary ground-glass attenuation.
    Eur Rev Med Pharmacol Sci 2017 Sep;21(18):4098-4103
    Department of Respiratory Medicine, The Affiliated Jiangyin Hospital of Southeast University, Jiangyin, Jiangsu Province, China.
    Objective: To compare the inflammatory factors and immune functions of patients with lung cancer and pulmonary ground-glass attenuation.

    Patients And Methods: A total of 108 patients with pulmonary sarcoidosis treated in our hospital were selected and randomly divided into lung cancer group (Group A, n=32), diffuse ground-glass nodule group (Group B, n=35) and solitary ground-glass nodule group (Group C, n=41) according to the diagnosis results. Levels of inflammatory factors, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-10 (IL-10), in serum were detected via enzyme-linked immunosorbent assay (ELISA); the T-lymphocyte subset levels (CD3+, CD4+, CD8+ and CD4+/CD8+) in the immune system of patients in the three groups were detected using the flow cytometer; the levels of immunoglobulins, immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM), were detected via immunoturbidimetric assay. Read More

    An unusual cutaneous infection caused by Mycobacterium marinum.
    JMM Case Rep 2017 Apr 12;4(4):e005088. Epub 2017 Apr 12.
    Department of Health Science, University of Eastern Piedmont, Novara, Italy.
    Introduction.Mycobacterium marinum is a non-tubercular mycobacterium residing in fresh or salt water (in tropical or temperate areas); it is a fish and human pathogen, and in immunocompromised patients can cause severe cutaneous and subcutaneous infections. Case presentation. Read More

    Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease.
    BMJ Case Rep 2017 Oct 11;2017. Epub 2017 Oct 11.
    Neurology, Universitair Medisch Centrum Groningen, Groningen, Netherlands.
    We present a case of a 57-year-old man who presented with progressive cerebellar dysarthria and cerebellar ataxia. Additional investigations confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML) in the posterior fossa. This is a demyelinating disease of the central nervous system, caused by an opportunistic infection with John Cunningham virus. Read More

    Clinical Characteristics of Ocular Sarcoidosis: A Population-Based Study 1976-2013.
    Ocul Immunol Inflamm 2017 Oct 12:1-7. Epub 2017 Oct 12.
    c Department of Ophthalmology , Mayo Clinic College of Medicine and Science , Rochester , Minnesota , USA.
    Purpose: To characterize the epidemiology and clinical characteristics of ocular involvement in patients with systemic sarcoidosis.

    Methods: An inception cohort of patients with systemic sarcoidosis in 1976-2013 in Olmsted County, Minnesota, was identified based on comprehensive individual medical record review. Medical records of those patients were then reviewed for ocular involvement. Read More

    Sudden failure of ventricular pacing and recovery in a patient with cardiac sarcoidosis.
    J Arrhythm 2017 Oct 26;33(5):521-522. Epub 2017 Jul 26.
    Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Iwate 0200066, Japan.
    A 76-year-old woman with sarcoidosis who had an implantable pacemaker for complete atrioventricular block was admitted with syncope. Electrocardiogram revealed ventricular pacing failure, and a marked rise in the ventricular pacing threshold. (18)F-Fluorodeoxyglucose positron emission tomography (FDG-PET) indicated increased uptake of FDG in the ventricular septum. Read More

    The value of endomyocardial biopsy in diagnosis and guiding therapy.
    Pathology 2017 Oct 8. Epub 2017 Oct 8.
    Department of Tissue Pathology and Diagnostic Oncology, ICPMR, Westmead Hospital, Westmead, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia. Electronic address:
    Endomyocardial biopsy (EMB) is a highly-specialised procedure that is associated with some controversy as to its diagnostic role due to its inconsistency in diagnosing a wide variety of cardiac diseases. Given the advances and sophistication in echocardiography and cardiac magnetic resonance imaging (MRI), the vast majority of cardiac diseases can be diagnosed by these non-invasive procedures. Under-sampling and the fact that biopsy site is limited to the right side of the interventricular septum further limits its value. Read More

    Higher Priced Older Pharmaceuticals: How Should We Respond?
    Chest 2017 Oct 7. Epub 2017 Oct 7.
    Medstar Washington Hospital Center, Washington, DC.
    We and our patients have been aware of the high cost of medications in the United States for decades. However, we are recently witnessing a relatively new phenomenon: exponential price increases for some older pharmaceuticals that have been available for years. To assist practitioners in how to respond to the issue of higher priced pharmaceuticals, an interprofessional session was developed and held at CHEST 2016 in Los Angeles. Read More

    Accuracy of Diagnostic Coding for Sarcoidosis in Electronic Databases: A Population-Based Study.
    Lung 2017 Oct 9. Epub 2017 Oct 9.
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, 200 First Avenue SW, Rochester, MN, 55905, USA.
    Purpose: Epidemiologic study of sarcoidosis utilizing electronic databases has been increasingly popular. However, the accuracy of diagnostic codes for sarcoidosis is unknown.

    Methods: The medical record-linkage system of the Rochester Epidemiology Project was searched to identify all potential adult cases of sarcoidosis between January 1, 1995 and December 31, 2013 in Olmsted County, Minnesota, using the International Classification of Diseases, Ninth Revision (ICD-9) code 135 (sarcoidosis). Read More

    Unilateral plantar erythema nodosum in sarcoidosis.
    Arthritis Rheumatol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
    A 32-year old male Caucasian patient presented with mild exertional dyspnea, pain and swelling of both ankles, and general malaise. On examination symmetrical arthritis of both ankles and a vivid nodular erythema with slight pain on pressure was detected on the sole of the right foot (A). A therapy with ibuprofen had not led to any improvement of symptoms. Read More

    Orbital Inflammation as a Presenting Sign for CREST Syndrome.
    Ophthal Plast Reconstr Surg 2017 Sep 27. Epub 2017 Sep 27.
    *Orbital Service, Moorfields Eye Hospital, and †Rheumatology Department, Guy's and St Thomas; Hospital, London, United Kingdom.
    A 61-year-old male was referred with a week's history of a painful and swollen left eye. Examination revealed normal visual acuities, left proptosis and global restriction of ocular ductions, and subretinal fluid at the macula. CT imaging confirmed thickening of the posterior scleral coat, with an associated choroidal effusion. Read More

    There is a need for new systemic sclerosis subset criteria. A content analytic approach.
    Scand J Rheumatol 2017 Oct 9:1-9. Epub 2017 Oct 9.
    aj Division of Rheumatology, Department of Medicine, St Joseph Health Care , University of Western Ontario , London , ON , Canada.
    Objectives: Systemic sclerosis (SSc) is heterogenous. The objectives of this study were to evaluate the purpose, strengths and limitations of existing SSc subset criteria, and identify ideas among experts about subsets.

    Methods: We conducted semi-structured interviews with randomly sampled international SSc experts. Read More

    Diseases of the peripheral nerves.
    Handb Clin Neurol 2017 ;145:453-474
    Institute of Neuropathology, RWTH Aachen University Hospital, Aachen, Germany. Electronic address:
    This chapter reviews the diseases of the peripheral nerves from a neuropathologic point of view, with a special focus on specific morphologic changes, and includes a summary of the histopathologic methods available for their diagnosis. As the rate of obesity and the prevalence of type 2 diabetes increase, diabetic neuropathy is the most common cause of peripheral neuropathy. Many systemic disorders with metabolic origin, like amyloidosis, hepatic failure, vitamin deficiencies, uremia, lipid metabolism disorders, and others, can also cause axonal or myelin alterations in the peripheral nervous system. Read More

    Acute and chronic bacterial infections and sarcoidosis.
    Handb Clin Neurol 2017 ;145:217-226
    Department of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address:
    Pathogen-induced inflammatory diseases mostly involving, but sometimes exclusively affecting, the central nervous system (CNS) manifest with a plethora of signs and symptoms. The different diseases are still difficult to cure despite modern diagnostic, preventive, and therapeutic advances, and this is mainly due to the host inflammatory response, leading to irreversible tissue damage. Knowledge about underlying pathomechanisms is constantly growing, and numerous studies on humans, human material, and animal models as well as in vitro systems have considerably increased our understanding of molecular mechanisms; however, there are still enormous uncertainties with respect to host-pathogen interaction and treatment. Read More

    A joint procedural position statement on imaging in cardiac sarcoidosis: from the Cardiovascular and Inflammation & Infection Committees of the European Association of Nuclear Medicine, the European Association of Cardiovascular Imaging, and the American Society of Nuclear Cardiology.
    Eur Heart J Cardiovasc Imaging 2017 Oct;18(10):1073-1089
    This joint position paper illustrates the role and the correct use of echocardiography, radionuclide imaging with 18F-fluorodeoxyglucose positron emission tomography, radionuclide myocardial perfusion imaging and cardiovascular magnetic resonance imaging for the evaluation and management of patients with known or suspected cardiac sarcoidosis. This position paper will aid in standardizing imaging for cardiac sarcoidosis and may facilitate clinical trials and pooling of multi-centre data on cardiac sarcoidosis. Proposed flow charts for the work up and management of cardiac sarcoidosis are included. Read More

    Cutaneous sarcoidosis: A retrospective case series and a hospital-based case-control study in Taiwan.
    Medicine (Baltimore) 2017 Oct;96(40):e8158
    Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Sarcoidosis is a systemic granulomatous disorder of unknown etiology often involving skin. Studies on cutaneous sarcoidosis and comorbidities are limited. This study is aimed to describe the clinical features of cutaneous sarcoidosis diagnosed in our hospital and to determine the relationships between cutaneous sarcoidosis and comorbidities. Read More

    Clinical and pathological feature of bone marrow granulomas: A modern Australian series.
    Int J Lab Hematol 2017 Oct 6. Epub 2017 Oct 6.
    Haematology Department, ACT Pathology, Garran, ACT, Australia.
    Introduction: Marrow granulomas have been commonly associated with mycobacterial infections, prompting extensive investigations in some cases where they are found, but in the setting of changing infectious epidemiology, there is a lack of recent data to guide the search for probable causes.

    Methods: A retrospective case series examining the clinical and pathological findings in all cases where marrow granulomas were reported over a 10-year period at The Canberra Hospital, Australia.

    Results: Of the 6062 marrow biopsies performed, 73 (1. Read More

    Diagnostic and therapeutic evaluation of multiple choroidal granulomas in a patient with confirmed sarcoidosis using enhanced depth imaging optical coherence tomography.
    Int Ophthalmol 2017 Oct 5. Epub 2017 Oct 5.
    Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama City, Kanagawa, 236-0004, Japan.
    Purpose: Sarcoidosis is a major cause of granulomatous uveitis but rarely manifests as multiple choroidal granulomas. This report describes the use of enhanced depth imaging optical coherence tomography (EDI-OCT) to visualize changes occurring in multiple choroidal granulomas during treatment.

    Methods: The patient was a 36-year-old Japanese man with histopathologically confirmed sarcoidosis, who was examined using EDI-OCT and showed multiple yellowish-white subretinal lesions in the peripapillary region and the arcade of the right eye. Read More

    Role of Cardiac Magnetic Resonance in the Diagnosis and Prognosis of Nonischemic Cardiomyopathy.
    JACC Cardiovasc Imaging 2017 Oct;10(10 Pt A):1180-1193
    Departments of Medicine and Radiology and the Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, Virginia. Electronic address:
    Cardiac magnetic resonance (CMR) is a valuable tool for the evaluation of patients with, or at risk for, heart failure and has a growing impact on diagnosis, clinical management, and decision making. Through its ability to characterize the myocardium by using multiple different imaging parameters, it provides insight into the etiology of the underlying heart failure and its prognosis. CMR is widely accepted as the reference standard for quantifying chamber size and ejection fraction. Read More

    Acute kidney injury as the presenting manifestation of sarcoidosis: A case series and review of literature.
    Nephrology (Carlton) 2017 Oct 4. Epub 2017 Oct 4.
    Nephrology and Transplantation Unit, John Hunter Hospital, Newcastle, NSW, Australia.
    Acute kidney injury is rarely the presenting feature of sarcoidosis. We present a case series of patients whose diagnosis of sarcoidosis was only brought to light by the development of renal impairment. Concurrent hypercalcaemia was noted, prompting further investigation. Read More

    Gene Expression Profiling and Heterogeneity of Nonspecific Orbital Inflammation Affecting the Lacrimal Gland.
    JAMA Ophthalmol 2017 Sep 21. Epub 2017 Sep 21.
    Casey Eye Institute, Oregon Health & Science University, Portland.
    Importance: Although a variety of well-characterized diseases, such as sarcoidosis and granulomatosis with polyangiitis, affect the lacrimal gland, many patients with dacryoadenitis are diagnosed as having nonspecific orbital inflammation (NSOI) on the basis of histology and systemic disease evaluation. The ability to further classify the disease in these patients should facilitate selection of effective therapies.

    Objective: To test the a priori hypothesis that gene expression profiles would complement clinical and histopathologic evaluations in identifying well-characterized diseases and in subdividing NSOI into clinically relevant groups. Read More

    Trends and Patterns of Differences in Chronic Respiratory Disease Mortality Among US Counties, 1980-2014.
    JAMA 2017 09;318(12):1136-1149
    Institute for Health Metrics and Evaluation, University of Washington, Seattle.
    Importance: Chronic respiratory diseases are an important cause of death and disability in the United States.

    Objective: To estimate age-standardized mortality rates by county from chronic respiratory diseases.

    Design, Setting, And Participants: Validated small area estimation models were applied to deidentified death records from the National Center for Health Statistics and population counts from the US Census Bureau, National Center for Health Statistics, and Human Mortality Database to estimate county-level mortality rates from 1980 to 2014 for chronic respiratory diseases. Read More

    Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases.
    World J Gastroenterol 2017 Sep;23(33):6137-6146
    Department of Medical Gastroenterology S, Odense University Hospital, 5000 Odense, Denmark.
    Aim: To investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD).

    Methods: In this population based registry study, a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16, 2013. Controls were randomly selected from the Danish Civil Registration System (CRS) and matched for sex, age, and municipality. Read More

    Unusual Clinical Presentations in Early-Onset Childhood Sarcoidosis: A Correlation or Coincidence?
    J Clin Diagn Res 2017 Aug 1;11(8):WD01-WD03. Epub 2017 Aug 1.
    Assistant Professor, Department of Pathology, Shaheed Hasan Khan Mewati, GMC, Nalhar, Rajasthan, India.
    Sarcoidosis is a multisystem granulomatous disease which frequently affects young adults. Because of its rarity, the exact incidence and prevalence of childhood sarcoidosis is not known. It mostly affects children of older age group i. Read More

    A review of the musculoskeletal manifestations of sarcoidosis.
    Rheumatology (Oxford) 2017 Aug 29. Epub 2017 Aug 29.
    Academic Department of Rheumatology, King's College London, London.
    Sarcoidosis is a systemic disease of unknown aetiology that is characterized by granulomatous inflammation that can develop in almost any organ system. Musculoskeletal manifestations are seen in up to one-third of patients, ranging from arthralgia through to widespread destructive bone lesions. Inflammatory tendon lesions and periarticular swelling are more common than true joint synovitis. Read More

    Right ventricular involvement and the extent of left ventricular enhancement with magnetic resonance predict adverse outcome in pulmonary sarcoidosis.
    ESC Heart Fail 2017 Oct 2. Epub 2017 Oct 2.
    Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
    Aims: Cardiac involvement is the main determinant of poor outcomes in sarcoidosis. Right ventricular (RV) dysfunction and left ventricular (LV) late gadolinium enhancement (LGE) have been reported to be predictive of adverse outcome in non-ischaemic cardiomyopathies. The aim of our study was to determine whether delayed RV LGE with cardiovascular magnetic resonance would be predictive of adverse events in addition to LV LGE during the long-term follow-up of pulmonary sarcoidosis patients. Read More

    [Sarcoid-like granulomatosis associated with eosinophilic fasciitis].
    Ann Dermatol Venereol 2017 Sep 26. Epub 2017 Sep 26.
    Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris-Diderot, Paris VII, 75010 Paris, France. Electronic address:
    Background: Eosinophilic fasciitis (EF) is a rare condition characterized by swelling of the extremities, sclerodermatous evolution and frequent hypereosinophilia. Hematological disorders, including aplastic anemia, solid tumors and autoimmune diseases, may be associated with EF. EF is usually not associated with granulomatous diseases. Read More

    Sinonasal and laryngeal sarcoidosis.
    Proc (Bayl Univ Med Cent) 2017 Oct;30(4):452-454
    Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.
    Sarcoidosis is a chronic granulomatous inflammation of uncertain etiology that can involve any organ system in the body. Sinonasal and laryngeal involvement is rare, poorly understood, and difficult to diagnose. Additionally, the extent of the disease is variable, and the response to systemic corticosteroids is often poor. Read More

    Elevated Serum Anti-GM-CSF Antibodies before the Onset of Autoimmune Pulmonary Alveolar Proteinosis in a Patient with Sarcoidosis and Systemic Sclerosis.
    Tohoku J Exp Med 2017 ;243(1):77-83
    Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine.
    Pulmonary alveolar proteinosis (PAP) is characterized by the accumulation of periodic acid-schiff stain-positive lipoproteinaceous materials in the alveolar space due to impaired surfactant clearance by alveolar macrophage. Autoimmune PAP is the most common form of PAP, but rarely accompanies collagen disease or sarcoidosis. We report here a rare case of autoimmune PAP preceded by systemic sclerosis and sarcoidosis. Read More

    Conventional Transbronchial Needle Aspiration: The Original Guard Who Still Has a Role in Mediastinal Lymph Node Sampling.
    J Bronchology Interv Pulmonol 2017 Oct;24(4):290-295
    *Department of Pulmonary, Critical Care and Sleep Medicine, Apollo Hospitals †Departmnet of Pathology, Fortis Hospitals, Bengaluru, Karnataka, India.
    Introduction: Conventional transbronchial needle aspiration (C-TBNA) is the originally described method for sampling mediastinal lymph nodes (MLN). After the advent of endobronchial ultrasound, the practice and reports of C-TBNA have dwindled. We report a large series of C-TBNA from the Indian subcontinent, highlighting aspects such as pathological spectrum, yield and complications, and reiterating its relevance in MLN sampling. Read More

    Disseminated Mycobacterium chimaera infection after open heart surgery in an Italian woman: a case report and a review of the literature.
    Infez Med 2017 Sep;25(3):267-269
    Infectious Diseases Department, University Hospital of Verona, Verona, Italy.
    We report the first Italian case of Mycobacterium chimaera disseminated infection in a patient with a history of cardiac surgery. The patient was initially diagnosed with sarcoidosis and started on immunosuppressive therapy. Ten months later she developed a vertebral osteomyelitis: M. Read More

    Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide.
    Ecancermedicalscience 2017 8;11:766. Epub 2017 Sep 8.
    Department of Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
    A 60-year-old woman under treatment with letrozole for metastatic breast cancer underwent (18)F-FDG PET-CT for restaging. A new widespread intense splenic FDG uptake without nodular lesions and multiple FDG-avid mediastinal and abdominal nodes were observed. Based on these findings, a nodal and transbronchial lung biopsy was performed. Read More

    Mass Cytometry Identifies Distinct Lung CD4(+) T Cell Patterns in Löfgren's Syndrome and Non-Löfgren's Syndrome Sarcoidosis.
    Front Immunol 2017 12;8:1130. Epub 2017 Sep 12.
    Respiratory Medicine Unit, Department of Medicine, Solna and Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
    Sarcoidosis is a granulomatous disorder of unknown etiology, characterized by accumulation of activated CD4(+) T cells in the lungs. Disease phenotypes Löfgren's syndrome (LS) and "non-LS" differ in terms of clinical manifestations, genetic background, HLA association, and prognosis, but the underlying inflammatory mechanisms largely remain unknown. Bronchoalveolar lavage fluid cells from four HLA-DRB1*03(+) LS and four HLA-DRB1*03(-) non-LS patients were analyzed by mass cytometry, using a panel of 33 unique markers. Read More

    Do you know this syndrome? Heerfordt-Waldenström syndrome.
    An Bras Dermatol 2017 Jul-Aug;92(4):571-572
    Private clinic - Jundiaí (SP), Brazil.
    Heerfordt-Waldenström syndrome is a rare subacute variant of sarcoidosis, characterized by enlargement of the parotid or salivary glands, facial nerve paralysis and anterior uveitis. Granulomas with a peripheral lymphocyte deficit are found in the anatomic pathology of affected organs. It is normally self-limiting, with cure achieved between 12 and 36 months, but some prolonged cases have been reported. Read More

    Heterogeneity of myocardial 2-[18F]fluoro-2-deoxy-D-glucose uptake is a typical feature in cardiac sarcoidosis: a study of 231 patients.
    Eur Heart J Cardiovasc Imaging 2017 Jul 28. Epub 2017 Jul 28.
    HUS Medical Imaging Center, Clinical Physiology and Nuclear Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland.
    Aims: The goal of the investigation was to evaluate whether a semi-quantitative method reflecting myocardial 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake heterogeneity has added value in addition to visual analysis in the diagnosis of cardiac sarcoidosis (CS).

    Methods And Results: This retrospective analysis included 271 consecutive patients suspected of CS attending cardiac positron emission tomography combined with computed tomography (PET-CT) at our institution between 2007 and 2013. Visual analysis of PET-CT and semi-quantitative analysis of heterogeneity [coefficient of variation (CoV)] of myocardial FDG uptake were performed. Read More

    The complimentary role of transbronchial lung cryobiopsy and endobronchial ultrasound fine needle aspiration in the diagnosis of sarcoidosis.
    Respir Med 2017 Oct 4;131:65-69. Epub 2017 Aug 4.
    Interventional Pulmonology, Division of Pulmonary and Critical Care Medicine, University of Cincinnati, Cincinnati, OH 45219, USA.
    Purpose: Transbronchial lung cryobiopsy (TBLC) is a novel technique that has proved to be useful in diagnosing various interstitial lung diseases (ILD). The use of TBLC to diagnose sarcoidosis in an unselected patient population is unknown, and could be complimentary to endobronchial ultrasound fine needle aspiration (EBUS-FNA).

    Methods: A retrospective analysis of 36 patients in a single, tertiary-care, academic medical center was conducted to describe the yield of both EBUS-FNA and TBLC in the diagnosis of suspected sarcoidosis over a three year period. Read More

    Sarcoidosis with Pancreatic Mass, Endobronchial Nodules, and Miliary Opacities in the Lung.
    Intern Med 2017 Sep 25. Epub 2017 Sep 25.
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
    Sarcoidosis affects multiple organs and rarely has unusual manifestations. A 78-year-old woman was referred to our hospital for coughing symptoms. A chest computed tomography (CT) scan revealed bilateral diffuse miliary patterns and right pleural effusion. Read More

    Sarcoidosis vs tuberculosis: Diagnostic mystery still unresolved.
    Indian J Tuberc 2017 Oct;64(4):243-245
    All India Institute of Medical Sciences, India.
    Sarcoidosis and tuberculosis are chronic, multisystemic, granulomatous disease of alike clinical, radiological and histopathological manifestations. Idiopathic nature of the disease and a strong clinical similarity with tuberculosis make the effectiveness of various clinical examinations for the diagnosis of sarcoidosis difficult in a tuberculosis endemic area. Presently confirmation of a diagnosis of sarcoidosis in most cases requires a biopsy which is often not confirmatory. Read More

    Right ventricular scar-related ventricular tachycardia in non-ischemic cardiomyopathy: Electrophysiological characteristics, mapping and ablation of underlying heart disease.
    J Cardiovasc Electrophysiol 2017 Sep 21. Epub 2017 Sep 21.
    Arrhythmia Service, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
    Background: Right ventricular (RV)-scar related ventricular tachycardia (VT) is often due to arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) or cardiac sarcoidosis (CS), but some patients whose clinical course has not been described do not fulfill diagnostic criteria for these diseases. We sought to characterize the electrophysiologic substrate and catheter ablation outcomes of such patients, termed RV cardiomyopathy of unknown source (RCUS).

    Methods And Results: Data of 100 consecutive patients who presented with RV cardiomyopathy and/or RV-related VT for ablation was reviewed (51 ARVC/D, 22 CS; 27 RCUS). Read More

    Acute kidney injury with granulomatous interstitial nephritis and vasculitis revealing sarcoidosis.
    Saudi J Kidney Dis Transpl 2017 Sep-Oct;28(5):1157-1161
    Department of Medicine A, Charles Nicolle Hospital, Tunis, Tunisia.
    Sarcoidosis is an inflammatory disease that affects mostly the lungs and lymph glands. Renal involvement is rare and especially vasculitis. We report a case who presented an acute kidney failure and had sarcoidosis with vasculitis and nodular splenic involvement. Read More

    Patterns of Intermediate Uveitis in Children Presenting at a Tertiary Eye Care Center in South India.
    Middle East Afr J Ophthalmol 2017 Apr-Jun;24(2):94-99
    Department of Uveitis and Ocular Pathology, Sankara Nethralaya, Chennai, Tamil Nadu, India.
    Purpose: To study the patterns of intermediate uveitis in the pediatric age group in a referral eye care center in South India.

    Methods: This is a study of twenty consecutive patients under 16 years of age with intermediate uveitis, conducted at a tertiary referral center. Numerous variables were assessed, including age and gender distribution, laboratory data, the presence of systemic diseases, onset and course of ocular inflammation, clinical features, their complications, therapeutic strategies with their outcomes, remission, final visual acuity (VA), and characteristics associated with poor visual outcome. Read More

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