29,342 results match your criteria Sarcoidosis


Sarcoidosis and the Th1 chemokine MIG.

Authors:
F Ragusa

Clin Ter 2018 Nov-Dec;169(6):e308-e313

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Sarcoidosis is a systemic inflammatory disease, affecting any organ, and that can be discovered by accident in approximately 5% of cases. High levels of the type-1 helper (Th1)-dependent chemokine, monokine induced by interferon (IFN)-γ (MIG)/chemokine (C-X-C motif) ligand (CXCL)9, and its receptor CXCR3 have been reported in bronchoalveolar lavage and biopsy samples of patients with sarcoidosis. These elevated levels are related with the amount of CD4+ lymphocytes and total lymphocytes. Read More

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December 2018
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Specific features of immune complexes in patients with sarcoidosis and pulmonary tuberculosis.

Immunol Res 2018 Dec 14. Epub 2018 Dec 14.

FGBU "St. Petersburg Scientific Research Institute of Phthisiopulmonology" of the Ministry of Health of Russia, St. Petersburg, Russia.

Clinical and radiological features of tuberculosis and sarcoidosis are quite overlapping, and therefore, a diagnostic dilemma often persists. There are no commonly accepted criteria for the diagnosis of sarcoidosis due to the lack of data on the etiology of the disease. The exclusion of tuberculosis in every patient with suspected sarcoidosis is a mandatory stage of diagnosis, especially in countries with a high burden of tuberculosis. Read More

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December 2018
1 Read

The long-term prognostic significance of sarcoidosis-associated pulmonary hypertension - A cohort study.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

Background: Sarcoidosis is a multisystem, chronic, progressive, granulomatous disease. Sarcoidosis-associated pulmonary hypertension is a well described, but not common, complication of sarcoidosis. In small scale studies, it has been previously described as manifestation of advanced disease and was found to be associated increased morbidity and mortality. Read More

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December 2018

Sarkoidosis and its Eye Ocular Manifestation (an Analysis of Six Case Report).

Cesk Slov Oftalmol 2018 ;73(5-6):189-197

Aim: To introduce the range of eye changes in sarcoidosis in the individual casuistics.

Materials: At the Ophthalmic Clinic of Teaching Hospital Královské Vinohrady in Prague were examined and treated six patients with ocular forms of sarcoidosis in the years from 1998 to 2015. Three patients were unilateral lesions of the lacrimal gland without systemic symptoms. Read More

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January 2018

Molecular phenotyping of infiltrative cardiomyopathies: The future.

J Nucl Cardiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, Cornell University Medical Center, New York, USA.

Cardiac sarcoidosis and amyloidosis have gained recent attention due to substantial advances in imaging and management. In this issue of the Journal of Nuclear Cardiology, imaging experts discuss the role of microvascular perfusion, innervation, targeted imaging of the heart and whole body, and novel molecular targets for imaging inflammation, fibrosis, and amyloidosis. In addition to cutting edge science, experts provide, for the first time, a patient page with information for patients with sarcoidosis and amyloidosis. Read More

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December 2018

Long-lasting cutaneous tuberculosis owing to masquerading as sarcoidosis.

JAAD Case Rep 2019 Jan 27;5(1):1-4. Epub 2018 Nov 27.

Dermatology Department, University Hospital of Bordeaux, Bordeaux, France.

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January 2019
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Corrigendum to "Spontaneous Resolution of Symptomatic Hepatic Sarcoidosis".

Case Rep Gastrointest Med 2018 6;2018:8603896. Epub 2018 Nov 6.

Department of Community Medicine, Department of Internal Medicine, Mercer University School of Medicine, Macon, GA, USA.

[This corrects the article DOI: 10.1155/2018/1535049.]. Read More

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November 2018

Sarcoidosis and Its Splenic Wonder: A Rare Case of Isolated Splenic Sarcoidosis.

Case Rep Med 2018 5;2018:4628439. Epub 2018 Nov 5.

Texas A&M University, College Station, TX, USA.

Sarcoidosis is a systemic granulomatous disease of unknown etiology characterized by presence of noncaseating granulomas in the involved organs. The pulmonary interstitium is most commonly affected but extrapulmonary involvement can occur in almost any other organ system. Such an involvement can occur with or without the presence of pulmonary involvement, but isolated extrapulmonary involvement has been noted only in around 10% of cases. Read More

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November 2018

Treatment of cardiac sarcoidosis: A comparative study of steroids and steroids plus immunosuppressive drugs.

Int J Cardiol 2018 Nov 30. Epub 2018 Nov 30.

Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Paris, France; Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases), Paris, France; INSERM U1149, Paris, France. Electronic address:

Background: We aimed to compare the efficacy of steroids alone or associated with immunosuppressive drugs for the prevention of relapse in cardiac sarcoidosis (CS).

Methods: In this monocentric multidisciplinary retrospective single center study, all consecutive patients with histologically proven sarcoidosis hospitalized from January 2012 to December 2016 were considered. All patients with symptomatic CS were studied. Read More

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November 2018

Long-Term Outcome in Probable Versus Absolute Cardiac Sarcoidosis.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Division of Cardiology, Heart and Lung Center, Helsinki University Central Hospital, and University of Helsinki, Helsinki, Finland.

Suspicion of cardiac sarcoidosis (CS) arises when a patient has clinical cardiac manifestations and findings on cardiac imaging suggestive of inflammatory cardiomyopathy with or without history of extracardiac sarcoidosis. The additional requirement for diagnosis is proof of sarcoidosis histology. Endomyocardial biopsy (EMB) showing granulomatous inflammation in absence of other explanations confirms an absolute diagnosis of CS while similar histology in an extracardiac biopsy gives a probable diagnosis of CS. Read More

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November 2018
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Coexistent sarcoidosis and lymphangioleiomyomatosis in a patient with cystic lung disease.

Respirol Case Rep 2019 Feb 28;7(2):e00389. Epub 2018 Nov 28.

Department of Respiratory Medicine Cork University Hospital Ireland.

A 45-year-old lady presented acutely with pleuritic chest pain, haemoptysis, and dyspnoea. Her background was significant for a 1.4 cm renal angiomyolipoma, and she was an ex-smoker without any relevant family history. Read More

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February 2019
2 Reads

Differential diagnosis of idiopathic inflammatory myopathies in adults - the first step when approaching a patient with muscle weakness.

Reumatologia 2018 31;56(5):307-315. Epub 2018 Oct 31.

Department of Systemic Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, Warsaw, Poland.

Despite its misleading adjective, the most commonly used diagnostic criteria of idiopathic inflammatory myopathies (IIM) are applicable only after all other non-autoimmune muscle diseases have been excluded. It makes differential diagnosis the first step when approaching a patient with muscle weakness. This article is designed to list the most common conditions from which to differentiate in rheumatological care. Read More

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October 2018
1 Read

A Retrospective Observational Study of Uveitis in a Single Center in Poland with a Review of Findings in Europe.

Med Sci Monit 2018 Dec 3;24:8734-8749. Epub 2018 Dec 3.

Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND This study aimed to review the causes, presentation, and clinicopathological associations of uveitis in a single department of ophthalmology in Poland, and to compare the findings with previously published studies from other European countries. MATERIAL AND METHODS Review of local patient records between 2005-2015 identified patients diagnosed with uveitis. Data obtained included age, gender, imaging findings, and laboratory diagnostic findings. Read More

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December 2018
4 Reads

Cardiac Sarcoidosis.

Am J Cardiol 2018 Nov 6. Epub 2018 Nov 6.

Cardiovascular Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Clinical and subclinical cardiac sarcoidosis (CS) remains diagnostically challenging as the sensitivity and specificity of the diagnostic modalities are limited. The Japanese Ministry of Health and Welfare criteria and the Heart Rhythm Society expert consensus statement on CS are the most common guidelines used to diagnose CS. However, they are mostly based on expert opinions and lack clinical trial validation. Read More

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November 2018
2 Reads

Silicosis, sarcoidosis and systemic sclerosis in the same patient.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Unidad de Enfermedades Sistémicas, Reumatología, Hospital General de Granollers, Granollers, Barcelona, España.

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November 2018
1 Read

Parotid abscess secondary to brucellosis in a patient with primary Sjögren's syndrome.

Eur J Rheumatol 2018 Mar;5(1):62-64

Department of Rheumatology, Fırat University School of Medicine, Elazığ, Turkey.

Swelling in the salivary glands, particularly parotid glands, is observed in approximately one third of Sjögren's syndrome patients. However, such patients should be assessed in terms of causes such as malignancies, infections, amyloidosis, sarcoidosis, and other autoimmune diseases when parotid gland swelling is noted. It should be considered that the incidence of lymphoma increases in Sjögren's syndrome. Read More

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March 2018
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FDG PET/CT Course of Pembrolizumab-Associated Multiorgan Sarcoidosis.

Authors:
Yang Lu

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

From the Department of Nuclear Medicine, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

An 80-year-old man with metastatic melanoma had been receiving treatment with pembrolizumab from September 2015 until June 2017. Series FDG PET/CT scans from March 7, 2017, to June 14, 2018, showed the course of biopsy-proven pembrolizumab-induced sarcoidosis. Reported here is the first case of multiorgan sarcoidosis induced by pembrolizumab and its self-resolving course on FDG PET/CT. Read More

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December 2018
5 Reads

[EFFECTIVENESS AND SAFETY OF METHOTREXATE MONOTHERAPY IN PATIENTS WITH PULMONARY SARCOIDOSIS].

Georgian Med News 2018 Oct(283):34-38

State Institution "National Institute of Phthisiology and Pulmonology them. F. G. Yanovsky NAMS of Ukraine ", Kiev, Ukraine.

Immunosuppressants are traditionally administered in sarcoidosis patients with contraindications for the use of glucocorticosteroids (GCS), or in those with serious adverse reactions on GCS, as well as in the cases of GCS-therapy resistance. Aim - to study the effectiveness and safety of methotrexate monotherapy in pulmonary sarcoidosis patients with either GCS contraindication or adverse reactions. We examined 33 patients with st. Read More

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October 2018
2 Reads

Second-harmonic generation imaging analysis can help distinguish sarcoidosis from tuberculoid leprosy.

J Biomed Opt 2018 Dec;23(12):1-7

Technology on Photonics Applied to Cell Biology, Campinas, Brazil.

Sarcoidosis and tuberculoid leprosy (TL) are prototypes of granulomatous inflammation in dermatology, which embody one of the histopathology limitations in distinguishing some diseases. Recent advances in the use of nonlinear optical microscopy in skin have enabled techniques, such as second-harmonic generation (SHG), to become powerful tools to study the physical and biochemical properties of skin. We use SHG images to analyze the collagen network, to distinguish differences between sarcoidosis and TL granulomas. Read More

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December 2018
3 Reads
2.859 Impact Factor

Multiorgan accelerated silicosis misdiagnosed as sarcoidosis in two workers exposed to quartz conglomerate dust.

Occup Environ Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.

Introduction: Clusters of silicosis cases have been reported in the fabrication of quartz conglomerate, a new high-silica-content artificial stone for kitchen and bathroom benchtops (countertops).

Aim: We describe two cases of accelerated-type silicosis with hepatic granulomas arising in workers exposed to artificial quartz conglomerates.

Methods: A confident diagnosis of multiorgan silicosis was based on high level of respirable silica in the workplace, typical radiological alterations in chest high-resolution CT, histological findings in the lung and liver, and detection of silica crystals in both tissues by phase-contrast polarising light microscopy and scanning electron microscopy and energy dispersive spectroscopy. Read More

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December 2018
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Is SUVmax Helpful in the Differential Diagnosis of Enlarged Mediastinal Lymph Nodes? A Pilot Study.

Contrast Media Mol Imaging 2018 28;2018:3417190. Epub 2018 Oct 28.

Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Objective: To explore the diagnostic value of maximum standard uptake value (SUVmax) from F-FDG PET/CT images in enlarged mediastinal lymph nodes of unknown etiology.

Methods: We performed a retrospective study of patients with enlarged mediastinal lymph nodes on F-FDG PET/CT scans. SUVmax and the short axis and long axis of lymph nodes were recorded. Read More

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October 2018
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Infections with Mycobacterium chimaera and open chest surgery. An unresolved problem.

Med Clin (Barc) 2018 Nov 30. Epub 2018 Nov 30.

Servicio de Medicina Preventiva y Epidemiología, Hospital Universitario Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.

Mycobacterium chimaera (M. chimaera) is a non-tuberculous mycobacterium of the Mycobacterium avium complex. Between 2013 and April 2018, more than 140 cases of severe infection have been identified, all of them in patients who had undergone cardiothoracic surgery with extracorporeal circulation. Read More

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November 2018
1 Read

Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study.

Respir Res 2018 Dec 3;19(1):236. Epub 2018 Dec 3.

Division of Physiological Chemistry II, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, 17177, Stockholm, Sweden.

Background: Sarcoidosis is a systemic inflammatory multi-organ disease almost always affecting the lungs. The etiology remains unknown, but the hallmark of sarcoidosis is formation of non-caseating epithelioid cells granulomas in involved organs. In Scandinavia, > 30% of sarcoidosis patients have Löfgren's syndrome (LS), an acute disease onset mostly indicating a favorable prognosis. Read More

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December 2018
1 Read

[Ocular sarcoidosis as a clinical manifestation of multiorgan involvement].

Vestn Oftalmol 2018 ;134(5):32-38

Saint Petersburg branch of S. Fyodorov Eye Microsurgery Federal State Institution, 21 Yaroslava Gasheka St., Saint Petersburg, Russian Federation, 192283.

Eye lesion in sarcoidosis is often the first and only sign of a disorder, which suggests a possible systemic disease. Currently sarcoidosis is considered a multisystemic granulomatous disease that requires multidisciplinary approach.

Purpose: To study the prevalence and clinical aspects of sarcoidosis eyes based on the representative sample of patients diagnosed with extraocular nonspecific granulomatous disease. Read More

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January 2018
4 Reads

[Acoustic analysis of the lacrimal gland in sarcoidosis].

Vestn Oftalmol 2018 ;134(5. Vyp. 2):148-155

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021; I.M. Sechenov First Moscow Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991.

Purpose: To analyze the condition of the lacrimal gland in patients confirmed to have sarcoidosis.

Material And Methods: The study included 46 patients (92 orbits) with verified diagnosis of systemic sarcoidosis that were examined during the period of 2009 to 2014. The age of patients ranged from 23 to 65 years and the average was 45. Read More

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January 2018
1 Read

Asymmetric lacrimal gland enlargement: an indicator for detection of pathological entities other than thyroid eye disease.

Graefes Arch Clin Exp Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Department of Oculoplastic, Orbital, and Lacrimal Surgery, Aichi Medical University Hospital, 1-1 Yazako-Karimata, Nagakute, Aichi, 480-1195, Japan.

Purpose: To examine the clinicopathological characteristics of patients with thyroid eye disease (TED) who showed asymmetric lacrimal gland enlargement.

Methods: Sixteen patients were included in this retrospective, observational case series. The following data were collected: sex, age, laterality, past medical history, laboratory results for thyroid function and other autoimmune disorders, pathological results, other systemic lesions related to lacrimal gland pathology, and the clinical course after treatment. Read More

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November 2018
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Paracoccidioidomycosis manifested by sarcoidosis-like cutaneous lesions and caused by Paracoccidioides brasiliensis sensu stricto (S1a).

An Bras Dermatol 2018 Nov/Dec;93(6):902-904

Laboratory of Medical Mycology, Departamento de Microbiologia e Imunologia, Instituto de Biociências de Botucatu, Universidade Estadual Paulista, Botucatu (SP), Brazil.

Molecular studies have shown more than one species of the genus Paracoccidioides to be the causal agent of paracoccidioidomycosis. Efforts have been made to correlate the identified species with epidemiological and clinical data of patients, aiming to determine the real meaning and impact of new species. Bearing this objective in mind, the authors report a clinical case of paracoccidioidomycosis, from São Paulo state, Brazil, that manifested as uncommon sarcoid-like cutaneous lesions and was caused by Paracoccidioides brasiliensis sensu stricto (S1a). Read More

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March 2018
3 Reads

Evaluation of FDG PET combined with cardiac MRI for the diagnosis and therapeutic monitoring of cardiac sarcoidosis.

Clin Radiol 2018 Oct 25. Epub 2018 Oct 25.

Department of Nuclear Medicine, Hôpital Avicenne, Paris 13 University, Bobigny, France. Electronic address:

Aim: To compare combined 2-[F]-fluoro-2-deoxy-d-glucose (FDG)-positron-emission tomography (PET) and cardiac magnetic resonance imaging (CMR) for the diagnosis and therapy monitoring of cardiac sarcoidosis (CS).

Materials And Methods: Eighty patients with sarcoidosis and a suspicion of CS who underwent PET and CMR were included retrospectively. PET was undertaken after a low-carbohydrate-high-fat diet in all patients using a combined 16-section PET/computed tomography (CT) camera. Read More

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October 2018
1 Read

Comparison of Retinal and Choroidal Involvement in Sarcoidosis-related Chorioretinitis Using Fluorescein and Indocyanine Green Angiography.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):426-432

Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialised Care, Teaching Centre Clinic Montchoisi, Lausanne, Switzerland.

Purpose: To compare the involvement of the retina with that of the choroid in ocular sarcoidosis (OS) using dual fluorescein angiography (FA)/indocyanine green angiography (ICGA).

Methods: A retrospective study of 23 patients with the diagnosis of OS was performed. Angiographic signs were quantified following the established FA/ICGA scoring system for uveitis. Read More

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November 2018
5 Reads

Answer: Pulmonary tuberculosis in sarcoidosis patients: two cases.

Tuberk Toraks 2018 09;66(3):272

Dr. Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital, Izmir, Turkey.

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September 2018
3 Reads

Pulmonary tuberculosis developed in sarcoidosis patients.

Tuberk Toraks 2018 09;66(3):271

Division of respiratory Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Japan.

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September 2018
3 Reads

[Causes of mediastinal/hilar granulomatous lymphadenitis].

Tuberk Toraks 2018 Sep;66(3):212-216

Department of Pathology, Faculty of Medicine, Karadeniz Teknik University, Trabzon, Turkey.

Introduction: Granulomatous lung disease (GLD) is caused by a wide range of conditions and it is challenge for pulmonologist. A detailed history of exposures is fundamental in GDL and has been found pivotal to reach a precise diagnosis.

Materials And Methods: Between September 2014 and December 2016, the distribution of patients diagnosed with granulomatous lymphadenitis in the mediastinal/hilar lymph nodes by endobronchial ultrasound (EBUS) or mediastinoscopy was analyzed. Read More

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September 2018
8 Reads

Conditions and Factors Associated With Spontaneous Coronary Artery Dissection (from a National Population-Based Cohort Study).

Am J Cardiol 2018 Oct 30. Epub 2018 Oct 30.

Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

The pathophysiology of spontaneous coronary artery dissection (SCAD) is heterogeneous, associated with systemic arteriopathies and inflammatory diseases, and often compounded by environmental precipitants, genetics, or stressors. However, the frequency of these associated conditions with SCAD on a population level remains unknown. Therefore, the objective of this analysis was to evaluate heterogeneous phenotypes of SCAD in the United States using data from the Nationwide Inpatient Sample collected from January 1, 2004, to September 31, 2015. Read More

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October 2018
1 Read
3.280 Impact Factor

Scalp Sarcoidosis Presenting as Cicatricial Alopecia.

J Am Osteopath Assoc 2018 Dec;118(12):824-826

Sarcoidosis is a granulomatous condition that has a highly variable presentation. One rare presentation of sarcoidosis is cutaneous scalp sarcoidosis. Usually scalp sarcoid presents as a scarring alopecia, but it can be nonscarring. Read More

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December 2018
2 Reads

Dural based marginal zone lymphoma in a patient with sarcoidosis: a case report.

World Neurosurg 2018 Nov 23. Epub 2018 Nov 23.

Neuropathology Section, Department of Pathology and Molecular Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada. Electronic address:

Background: Primary dural based lymphoma is a rare disease entity. It has beenhypothesized that patients with sarcoidosis are at increased risk of developing lymphoma, an association known as "sarcoidosis-lymphoma syndrome", although dural disease has been not yet reported in the literature.

Case Description: Here we report the first case of dural based lymphoma in a 60-year-old; man with a history of sarcoidosis, in keeping with sarcoidosis-lymphoma syndrome. Read More

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November 2018
1 Read

Quantitative image analysis using chest computed tomography in the evaluation of lymph node involvement in pulmonary sarcoidosis and tuberculosis.

PLoS One 2018 26;13(11):e0207959. Epub 2018 Nov 26.

Division of Pulmonary Medicine, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

Purpose: To evaluate the feasibility of quantitative analysis of chest computed tomography (CT) scans for the assessment of lymph node (LN) involvement in patients with pulmonary tuberculosis and sarcoidosis.

Methods: In 47 patients with tuberculosis (n = 26) or sarcoidosis (n = 21), 115 lymph nodes (tuberculous, 55; sarcoid, 60) were visually analyzed on chest CT scans according to their size, location, attenuation and shape. Each node was manually segmented using image analysis tool, which was quantitatively analyzed using the following variables: Feret's diameter, perimeter, area, circularity, mean grey value (Mean), standard deviation (SD) of grey value, minimum grey value (Min), maximum grey value (Max), median grey value (Median), skewness, kurtosis, and net enhancement. Read More

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November 2018
5 Reads

Limbic encephalitis: Experience of a moroccan center.

Brain Behav 2018 Nov 25:e01177. Epub 2018 Nov 25.

Department of Neurology, Hassan II University Teaching Hospital, Fez, Morocco.

Objectives: Histologically defined as an inflammation-degeneration of limbic structures, limbic encephalitis (LE) is a rare disease and often difficult to diagnose particularly in institutions with limited access to laboratory tests such as antineuronal antibodies or HSV-PCR, and functional imaging. We aimed to describe the demographic, clinical, paraclinical, and etiological features of LE, as well as its medium-term prognosis in Moroccan patients.

Materials And Methods: We collected retrospectively all patients diagnosed with LE in the Department of Neurology of the University Hospital Hassan II of Fez (Morocco) between September 2008 and December 2016. Read More

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November 2018
5 Reads

Detection of mitochondrial transfer RNA (mt-tRNA) gene mutations in patients with idiopathic pulmonary fibrosis and sarcoidosis.

Mitochondrion 2018 Nov 26;43:43-52. Epub 2018 Oct 26.

Department of Biochemistry & Biotechnology, University of Thessaly, BIOPOLIS, Larissa 41110, Greece.

Mitochondrial reactive oxygen species production may lead to tissue injury associated with two respiratory disorders of unknown origin which are shared by common tissue fibrosis, IPF and sarcoidosis. Sequence analysis of 22 mt-tRNA genes and parts of their flanking genes revealed 32 and 45 mutations in 38/40 IPF and 69/85 sarcoidosis patients respectively. 4 novel mutations were identified. Read More

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November 2018
1 Read

Sarcoidosis deaths in the United States: 1999-2016.

Respir Med 2018 Nov 16. Epub 2018 Nov 16.

Program in Lung Cell Biology and Translational Research, Division of Pulmonary and Critical Care, Brody School of Medicine, East Carolina University, USA. Electronic address:

Background: It has been over a decade since a comprehensive study has been published that has examined sarcoidosis deaths at the national level. The purpose of this study was to analyze sarcoidosis as the underlying cause of death using current national death certificate data. Results from this project can be used to evaluate and compare trends of sarcoidosis reported deaths across the U. Read More

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November 2018
1 Read

Effect of Cardiac Resynchronization Therapy on Left Ventricular Remodeling in Patients With Cardiac Sarcoidosis.

Am J Cardiol 2018 Oct 22. Epub 2018 Oct 22.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:

Cardiac resynchronization therapy (CRT) has been shown to be beneficial in patients with medically refractory heart failure. Although it has been found to be effective in a wide range of etiologies for nonischemic cardiomyopathy, its role in improving remodeling and survival of patients with cardiac sarcoidosis (CS) remains undefined. We performed a retrospective review of all patients at our institution with CS who underwent implantation of a CRT device from 2007 to 2017. Read More

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October 2018
1 Read

Importance of endomyocardial biopsy in distinguishing between cardiac sarcoidosis and giant cell myocarditis : Need to distinguish between sarcoidosis and giant cell myocarditis.

Wien Klin Wochenschr 2018 Nov 23. Epub 2018 Nov 23.

2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U Nemocnice 2, 12808, Prague, Czech Republic.

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November 2018
1 Read

Advances in Inflammatory Granulomatous Skin Diseases.

Dermatol Clin 2019 Jan;37(1):49-64

Dermatology Administration, Perelman Center for Advanced Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, 7th Floor, South Tower, Philadelphia, PA 19104, USA. Electronic address:

Inflammatory granulomatous dermatitides include cutaneous sarcoidosis, necrobiosis lipoidica, granuloma annulare, and reactive granulomatous dermatitis. The etiopathogenesis of these disorders is not well understood; but the T helper 1 response mediated by interferon-gamma, tumor necrosis factor-alpha, and interleukin (IL) 1, 2, and 6 and the T helper 17 response mediated by IL-17 play a role. These inflammatory granulomatous disorders often have cutaneous manifestations in addition to extracutaneous manifestations or associations with systemic diseases. Read More

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January 2019
7 Reads

Small Cell Lung Cancer with Sarcoidosis in Spontaneous Remission: A Case Report.

J Nippon Med Sch 2018 ;85(5):291-296

Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine.

A 69-year-old woman was diagnosed with sarcoidosis, which was not treated with corticosteroid therapy. Her levels of angiotensin converting enzyme decreased significantly over 4 years and a mass lesion was detected near the lower part of her left main bronchus, and diagnosed as small cell lung cancer (SCLC). Treatment of the SCLC with a series of chemotherapeutic agents produced excellent results. Read More

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January 2018
6 Reads

Potassium Iodide for Cutaneous Inflammatory Disorders: A Monocentric, Retrospective Study.

Dermatology 2018 Nov 21:1-7. Epub 2018 Nov 21.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Objectives: Potassium iodide (KI) is a medication that has been used for decades in dermatology and it is mentioned as a treatment option in all major dermatology textbooks. Yet, there is little recent information on its efficacy. In our study, we wanted to retrospectively evaluate the therapy response to KI in our patients. Read More

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November 2018
9 Reads

Current diagnostic strategies for dilated cardiomyopathy: a comparison of imaging techniques.

Expert Rev Cardiovasc Ther 2018 Nov 20:1-11. Epub 2018 Nov 20.

a Cardiovascular Department , Università degli Studi di Trieste , Trieste , Italy.

Introduction: Dilated cardiomyopathy (DCM) is generally thought as a final common pathway of several conditions leading to the same clinical phenotype. Multiple imaging modalities play a fundamental role in recognizing the underlying pathological substrate in DCM. Areas covered: Echocardiography represents the first reliable and easily accessible diagnostic tool, allowing the identification of associated cardiac abnormalities, such as valve disease and highlighting features associated with an adverse prognosis. Read More

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November 2018
5 Reads

Can pulmonary sarcoidosis trigger a progressive multifocal leukoencephalopathy? Considerations from a case series and a review of literature.

Clin Case Rep 2018 Nov 21;6(11):2121-2125. Epub 2018 Sep 21.

Abteilung für Neurologie Krankenanstalt Rudolfstiftung Wien Austria.

Progressive multifocal leukoencephalopathy (PML) is a severe infectious brain disease with lethal outcome mainly seen in immunocompromised subjects. Herein, we describe a new form of PML with different outcome which was observed in patients suffering from systemic sarcoidosis. Thus, we raise the question whether preexisting sarcoidosis might predispose for or even trigger PML. Read More

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November 2018
1 Read

Flow cytometric analysis of lymphocyte profiles in mediastinal lymphadenopathy of sarcoidosis.

PLoS One 2018 19;13(11):e0206972. Epub 2018 Nov 19.

Department of Respiratory Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

Lymphocyte profiles in mediastinal lymph nodes may reflect the immune status of patients with sarcoidosis. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is useful for the diagnosis of diseases with mediastinal lymphadenopathy including sarcoidosis. The purpose of this study was to determine lymphocyte profiles of lymph nodes in sarcoidosis by analyzing EBUS-TBNA samples. Read More

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November 2018
7 Reads

[A Case of Sarcoidosis Associated with Esophageal Cancer].

Gan To Kagaku Ryoho 2018 Nov;45(11):1649-1652

Dept. of Surgery, Yamagata Prefectural Central Hospital.

A 67-year-old man was diagnosed with esophageal cancer. Computed tomography(CT)revealed multiple sites of bilateral mediastinal lymph node swelling. Serum levels of soluble interleukin-2 receptor(sIL-2R)were elevated; however, serum levels of angiotensin-converting enzyme(ACE)were normal. Read More

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November 2018
6 Reads