28,922 results match your criteria Sarcoidosis


Significant elevation of the levels of B-cell activating factor (BAFF) in patients with sarcoidosis.

Clin Rheumatol 2018 Jun 23. Epub 2018 Jun 23.

Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, Japan.

B-cell activating factor (BAFF) plays an important role in the survival and differentiation of B-cells and production of antibodies. Recent studies show that the serum BAFF levels are elevated in patients with sarcoidosis; however, they have not studied the relationship of the finding with the clinical features of the disease. The purpose of the present study is to analyze the BAFF and to elucidate the relationship between BAFF levels and the disease activity or severity of sarcoidosis. Read More

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[Retinal vasculitis and systemic diseases].

Rev Med Interne 2018 Jun 19. Epub 2018 Jun 19.

Service de médecine interne et immunologie clinique, hôpital de la Conception, Aix-Marseille université, 147, boulevard Baille, 13005 Marseille, France. Electronic address:

Retinal vasculitis (RV) is an inflammation of retinal blood vessels that can be associated with uveitis or be isolated, and can induce vascular occlusion and retinal ischemia. Visual acuity can be severely affected in case of macular involvement or neovessel formation. The diagnosis relies on fundoscopy and fluorescein angiography. Read More

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Unique Variant of NOD2 Pediatric Granulomatous Arthritis With Severe 1,25-Dihydroxyvitamin D-Mediated Hypercalcemia and Generalized Osteosclerosis.

J Bone Miner Res 2018 Jun 22. Epub 2018 Jun 22.

Pediatrics / Hematology, CHOC Children's Hospital - UC Irvine; Orange, CA 92868, USA.

Pediatric granulomatous arthritis (PGA) refers to two formerly separate entities; autosomal dominant Blau syndrome (BS) and its sporadic phenocopy early-onset sarcoidosis (EOS). In 2001 BS and in 2005 EOS became explained by heterozygous mutations within the gene that encodes nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also called caspase recruitment domain-containing protein 15 (CARD15). NOD2 is a microbe sensor in leukocyte cytosol that activates and regulates inflammation. Read More

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Sarcoidosis onset simulating a unique hepatic metastasis.

Rev Esp Enferm Dig 2018 Jun 22;110. Epub 2018 Jun 22.

Hospital Campus de la Salud, España.

Sarcoidosis is a systemic granulomatous disease with an uncertain etiology, characterized by the production of non-necrotizing granulomas. The most frequent presentation is pulmonary and mediastinal, although it might affect any other organ. Hepatic alterations occur in 50 to 65% of the cases. Read More

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Clinical characteristics associated with pacing-induced cardiac dysfunction: a high incidence of undiagnosed cardiac sarcoidosis before permanent pacemaker implantation.

Heart Vessels 2018 Jun 21. Epub 2018 Jun 21.

Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, Saitama, 330-8503, Japan.

Previous studies suggested that right ventricular pacing was associated with pacing-induced cardiac dysfunction (PICD). The purpose of this study was to investigate the clinical characteristics including the incidence of undiagnosed cardiac sarcoidosis (CS) in patients with atrioventricular block (AVB) who manifest PICD. We retrospectively investigated consecutive patients with permanent pacemaker (PPM) undergoing a first-generator replacement surgery with a new PPM or an upgrade procedure to a cardiac resynchronization therapy (CRT) device between December 1, 2011 and June 30, 2017. Read More

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Stevens-Johnsons syndrome or drug-induced lupus - a clinical dilemma: A case report and review of the literature.

Biomed Rep 2018 Jul 16;9(1):37-41. Epub 2018 May 16.

Department of Internal Medicine and Rheumatology, 'Sfanta Maria' Hospital, 011172 Bucharest, Romania.

Tumor necrosis factor inhibitors are the first biological agents used in the treatment of rheumatoid arthritis (RA) to have yielded satisfactory results in terms of clinical improvement and radiologic progression, but they are also associated with the possibility of occurrence of a number of autoimmune systemic events [drug-induced lupus (DIL), vasculitis, sarcoidosis] and localized adverse events [uveitis, psoriasis, interstitial lung disease, erythema multiforme including the major form Stevens-Johnson syndrome (SJS)]. During treatment with TNF inhibitors, many patients develop positivity for antinuclear, antihistone and anti-double stranded DNA antibodies, though only a minority of patients will develop clinical manifestations and approximately less than 1% will fulfill the classification criteria for systemic lupus erythematosus. Mucocutaneous manifestations are the most frequent manifestations of DIL following treatment with TNF inhibitors, and can be severe and occasionally difficult to differentiate from erythema multiforme/SJS. Read More

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July 2018
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Nationwide survey on the organ-specific prevalence and its interaction with sarcoidosis in Japan.

Sci Rep 2018 Jun 21;8(1):9440. Epub 2018 Jun 21.

First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

Previous studies attempted to characterize the subjects with sarcoidosis according to differences in sex, age, and the presence of specific organ involvement. However, significant interactions among these factors precluded a clear conclusion based on simple comparison. This study aimed to clarify the age- and sex-stratified prevalence of specific organ involvement and the heterogenous nature of sarcoidosis. Read More

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Clinical and biochemical presentation of sarcoidosis with high and normal serum angiotensin-converting enzyme.

Scand J Rheumatol 2018 Jun 22:1-4. Epub 2018 Jun 22.

a Copenhagen Lupus and Vasculitis Clinic, Centre for Rheumatology and Spine Diseases , Rigshospitalet and University of Copenhagen , Copenhagen , Denmark.

Objectives: The presentation of sarcoidosis can involve symptoms from all organs and the diagnosis is therefore often difficult. A raised serum level of serum angiotensin-converting enzyme (sACE) can be detected in 41-58% of patients. However, whether the sACE level per se reflects the severity of the sarcoid inflammation at the onset of the disease is not well described. Read More

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Focus on increased serum angiotensin-converting enzyme level: From granulomatous diseases to genetic mutations.

Clin Biochem 2018 Jun 18. Epub 2018 Jun 18.

Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium; Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.

Angiotensin I-converting enzyme (ACE) is a well-known zinc-metallopeptidase that converts angiotensin I to the potent vasoconstrictor angiotensin II and degrades bradykinin, a powerful vasodilator, and as such plays a key role in the regulation of vascular tone and cardiac function. Increased circulating ACE (cACE) activity has been reported in multiple diseases, including but not limited to granulomatous disorders. Since 2001, genetic mutations leading to cACE elevation have also been described. Read More

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Clinical features of patients with homozygous complement C4A or C4B deficiency.

PLoS One 2018 21;13(6):e0199305. Epub 2018 Jun 21.

Transplantation Laboratory, Medicum, University of Helsinki, Helsinki, Finland.

Introduction: Homozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex. There are no studies where the clinical presentation of these patients is analyzed. Read More

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Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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June 2018
2 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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June 2018
1 Read

Granulomatous Tumoral Melanosis Associated With Pembrolizumab Therapy: A Mimicker of Disease Progression in Metastatic Melanoma.

Am J Dermatopathol 2018 Jul;40(7):523-526

Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada.

Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced melanoma, with these agents significantly improving survival for patients with metastatic disease. With the increasing use of these agents, the number of adverse reactions secondary to their use has also increased. Sarcoidosis and sarcoid-like reactions are one such immune checkpoint inhibitor-related adverse event. Read More

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July 2018
1 Read

Glucocorticoid exposure and fracture risk in a cohort of US patients with selected conditions.

J Bone Miner Res 2018 Jun 20. Epub 2018 Jun 20.

Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham AL.

Purpose: We evaluated systemic glucocorticoid exposure and fracture among patients with newly-diagnosed inflammatory and immune-modulated conditions.

Methods: Using administrative data, inception cohorts of RA, asthma/COPD, IBD, MS, lupus, and sarcoidosis patients age 18-64 years with benefits coverage ≥12 months before diagnosis (1/1/2005-12/31/2012) were followed to clinical fracture, cancer diagnosis, or 12/31/2012. Glucocorticoid users were new to therapy. Read More

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June 2018
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Sarcoidosis of the central nervous system: clinical features, imaging, and CSF results.

Authors:
Desmond P Kidd

J Neurol 2018 Jun 19. Epub 2018 Jun 19.

Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and Transplantation, University College London, London, NW3 2PF, UK.

Objective: Neurological complications of systemic sarcoidosis are uncommon and the natural history and optimal treatments under-researched. With the advent of modern biological therapies, it is important to define the clinical characteristics and immunopathology of the disease.

Methods: Patients referred to and treated within the Centre for Neurosarcoidosis over a 15 year period who had biopsy-proven "highly probable" disease of the central nervous system were studied prospectively. Read More

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June 2018
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Symptomatic sarcoidosis with stomach, duodenum, small intestine and parotid gland involvement.

Clin Res Hepatol Gastroenterol 2018 Jun 16. Epub 2018 Jun 16.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Digestive Diseases, Beijing, China. Electronic address:

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Identification of left ventricular chamber-like aneurysm related to cardiac sarcoidosis.

BMJ Case Rep 2018 Jun 17;2018. Epub 2018 Jun 17.

Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

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June 2018
1 Read

Case Report: Pulmonary and Liver Sarcoidosis Suspected of Metastasis.

F1000Res 2018 7;7:288. Epub 2018 Mar 7.

Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.

: Sarcoidosis is a granulomatous disease with unknown cause that can vary from an asymptomatic condition. Almost half of the patients with sarcoidosis have no symptoms. In this article, we describe a sarcoidosis patient with lung and liver engagement; it may be confused with metastasis. Read More

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March 2018
2 Reads

PPAR-gamma pathways attenuate pulmonary granuloma formation in a carbon nanotube induced murine model of sarcoidosis.

Biochem Biophys Res Commun 2018 Jun 15. Epub 2018 Jun 15.

Department of Internal Medicine, Pulmonary, Critical Care & Sleep Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA. Electronic address:

Peroxisome proliferator activated receptor gamma (PPARγ), a ligand activated nuclear transcription factor, is constitutively expressed in alveolar macrophages of healthy individuals. PPARγ deficiencies have been noted in several lung diseases including the alveolar macrophages of pulmonary sarcoidosis patients. We have previously described a murine model of multiwall carbon nanotubes (MWCNT) induced pulmonary granulomatous inflammation which bears striking similarities to pulmonary sarcoidosis, including the deficiency of alveolar macrophage PPARγ. Read More

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Atypical Cutaneous Presentations of Sarcoidosis: Two Case Reports and Review of the Literature.

Curr Allergy Asthma Rep 2018 Jun 14;18(8):40. Epub 2018 Jun 14.

Department of Medicine, Division of Rheumatology and Immunology, Duke University Medical Center, DUMC 2918, Durham, NC, 27710, USA.

Purpose Of Review: The goal of this review is to provide the reader with an updated summary of the cutaneous manifestations of systemic sarcoidosis, with a particular emphasis on the predilection of sarcoidosis for scars, tattoos, and other areas of traumatized skin.

Recent Findings: While the mechanism underlying the propensity for traumatized skin to develop sarcoidosis lesions remains unclear, several theories have been proposed including the idea that cutaneous sarcoidosis represents an exuberant, antigen-driven foreign-body response, as well as the theory that traumatized skin represents an immunocompromised district with altered local immune trafficking and neural signaling. In this review, we present two cases in which the development of cutaneous lesions in scars and tattoos was integral to the diagnosis of systemic sarcoidosis. Read More

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Thoracic and cutaneous sarcoid-like reaction associated with anti-PD-1 therapy: longitudinal monitoring of PD-1 and PD-L1 expression after stopping treatment.

J Immunother Cancer 2018 Jun 13;6(1):52. Epub 2018 Jun 13.

Service de Pneumologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49000, Angers, France.

Background: Immune checkpoint inhibitors (ICI) target T cell inhibitory pathways that are responsible for cancer tolerance by down-modulating immune functions. ICI have revolutionized patients care with lung cancer. Nevertheless, restoring endogenous antitumor T-cell responses can induce immune related adverse events, such as sarcoidosis. Read More

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Vaginal sarcoidosis without other organ involvement in a patient with a history of endometrial cancer: A case report.

Gynecol Oncol Rep 2018 Feb 10;23:34-36. Epub 2018 Jan 10.

Gynecologic Oncology Division, Department of Obstetrics and Gynecology, University of Virginia School of Medicine, Charlottesville, VA, United States.

•Patient with history of endometrial cancer presented with vaginal discharge.•Biopsy showed non-necrotizing granulomas, potentially sarcoidosis.•She responded to steroids with symptom resolution. Read More

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February 2018

Drug-induced sarcoidosis in a patient treated with an interleukin-1 receptor antagonist for hidradenitis suppurativa.

JAAD Case Rep 2018 Jul 6;4(6):543-545. Epub 2018 Jun 6.

Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania.

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The fear of lymphadenopathy: A cautionary case of sarcoidosis masquerading as recurrent diffuse large b-cell lymphoma (DLBCL).

Leuk Res Rep 2018 9;9:48-53. Epub 2018 Apr 9.

Floyd & Delores Jones Cancer Institute at Virginia Mason Medical Center, Seattle, WA, United States.

We describe the cautionary case of a patient with advanced-stage large B-cell lymphoma (DLBCL). After combination chemotherapy, CT-PET revealed a persistent focus of likely DLBCL for which he received radiotherapy. Follow-up CT-PET showed diffuse hypermetabolic adenopathy and recurrent DLBCL was presumed. Read More

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Immune-mediated ataxias.

Handb Clin Neurol 2018 ;155:313-332

French Reference Centre for Paraneoplastic Neurological Syndromes, Lyon Neurological Hospital, Lyon, France; Institut NeuroMyoGene, Université Claude Bernard Lyon 1, Lyon, France. Electronic address:

Immune-mediated cerebellar ataxia (CA) comprises a group of rare diseases that are still incompletely described, and are probably underdiagnosed. Both acute and progressive progressions are possible. Different syndromes have been identified, including CA associated with anti-GAD antibodies, the cerebellar type of Hashimoto encephalopathy, primary autoimmune CA, gluten ataxia, opsoclonus-myoclonus syndrome, and paraneoplastic cerebellar degenerations. Read More

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January 2018

The Fatigue Assessment Scale: quality and availability in sarcoidosis and other diseases.

Curr Opin Pulm Med 2018 Jun 7. Epub 2018 Jun 7.

ILD care foundation research team, Ede.

Purpose Of Review: Fatigue is a problem experienced by many patients suffering from chronic diseases, including sarcoidosis patients. It has a substantial influence on patients' quality of life (QoL). It is, therefore, important to properly assess fatigue with a valid and reliable measure. Read More

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Disseminated Multi-system Sarcoidosis Mimicking Metastases on F-FDG PET/CT.

Mol Imaging Radionucl Ther 2018 Jun;27(2):91-95

Jewish General Hospital, Department of Nuclear Medicine, Montreal, Canada.

A 60-year-old female with no significant medical history presented with hematuria. A computed tomography (CT) scan revealed extensive lymphadenopathy with hypodensities in the liver and spleen, and she was referred for an F-fluorodeoxyglucose (F-FDG) positron emission tomography/CT (PET/CT) study to assess for malignancy of unknown primary. PET/CT revealed extensive F-FDG avid lymphadenopathy as well as innumerable intensely F-FDG avid lung, liver and splenic nodules, highly concerning for malignancy. Read More

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Concomitant sarcoidosis and papillary thyroid cancer with severe hypercalcaemia as the main symptom.

BMJ Case Rep 2018 Jun 8;2018. Epub 2018 Jun 8.

Department of Internal Medicine, Randers Regional Hospital, Randers, Denmark.

A 65-year-old Caucasian man was admitted to our hospital due to incidental finding of plasma ionised calcium=1.83 mmol/L. During the previous months, he had felt more tired and had experienced an unintended weight loss of 6-8 kg. Read More

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June 2018
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The Curious Omission of Treatment as a Predictor of Pulmonary Sarcoidosis Mortality.

Authors:
Jerome M Reich

Chest 2018 Jun;153(6):1507

Thoracic Oncology Program, Earle A Chiles Research Institute, Portland, OR. Electronic address:

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Treatment of sarcoidosis: grading the evidence.

Expert Rev Clin Pharmacol 2018 Jun 18:1-11. Epub 2018 Jun 18.

b Department of Medicine , University of Cincinnati Medical Center , Cincinnati , OH , USA.

Introduction: Treatment of sarcoidosis recommendations are often based on clinical experience and expert opinion. However, there are an increasing number of studies which are providing evidence to support decisions regarding treatment. Areas covered: Several studies have identified factors associated with increased risk for organ failure or death ('danger'). Read More

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June 2018
5 Reads

[What rheumatologists can learn from ophthalmologists].

Z Rheumatol 2018 Jun 7. Epub 2018 Jun 7.

Klinik für Rheumatologie, Stadtspital Triemli, Zürich, Schweiz.

Intraocular inflammation with the imprecise and broad umbrella term "uveitis" is a diagnostic and therapeutic challenge in ophthalmology. Uveitis is one of the most common causes of blindness worldwide and due to the associated costs is comparable to diabetic retinopathy. Patients can be affected by uveitis at any age. Read More

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June 2018
1 Read

Restrictive lung defects: parenchymal, chest wall and neuromuscular.

Thorax 2018 Jun 7. Epub 2018 Jun 7.

Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.

Sarcoidosis is a multisystem condition which may affect a number of organs and, within the cardiopulmonary system, most commonly manifests as parenchymal, airway-centred, nodal, vascular or cardiac disease. Pleural involvement is rare, but well described, and often presents as pleural effusions or pleural thickening. Here, we present the first case of active sarcoidosis manifesting as bilateral pleural calcification. Read More

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June 2018
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Bi-atrial fibrosis detected using three-dimensional late gadolinium enhancement magnetic resonance imaging in a patient with cardiac sarcoidosis.

Oxf Med Case Reports 2018 May 16;2018(5):omy016. Epub 2018 May 16.

Department of Cardiac Electrophysiology, The University of Ottawa Heart Institute, 40 Ruskin Ave, K1Y 4W7, Ottawa, ON, Canada.

Presented is the case of a 62-year old male with a history of sarcoidosis and sinus node dysfunction, who underwent late gadolinium enhancement magnetic resonance imaging, which demonstrated left ventricular hyperenhancement and bi-atrial fibrosis. Read More

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Tuberculosis of the Oral Cavity Misdiagnosed as Precancerous Lesion.

Acta Stomatol Croat 2017 Dec;51(4):326-331

Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Introduction: The aim of this case report was to discuss an extremely rare oral lesion as a result of primary pulmonary tuberculosis.

Case Report: In this case report, the patient with refractory painless ulceration at ventral surface of the tongue was described. Detailed medical history was taken followed by clinical examination of the oral mucosa and palpation of regional lymph nodes. Read More

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December 2017

Urinary N-terminal fragment of titin is a marker to diagnose muscular dystrophy in patients with cardiomyopathy.

Clin Chim Acta 2018 Jun 2;484:226-230. Epub 2018 Jun 2.

Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

The differential diagnosis of cardiomyopathy is important. It has been recently reported that urinary titin N (U-TN) is increased in patients with muscular dystrophy (MD), and is associated with muscular damage. We aimed to clarify whether U-TN is useful as a diagnostic tool for distinguishing MD from various cardiomyopathies [e. Read More

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Disseminated Exophiala dermatitidis causing septic arthritis and osteomyelitis.

BMC Infect Dis 2018 Jun 4;18(1):255. Epub 2018 Jun 4.

Division of Infectious Diseases, Department of Medicine, University of Saskatchewan, Regina, Saskatchewan, Canada.

Background: Exophiala dermatitidis is a melanized fungus isolated from many environmental sources. Infections caused by Exophiala species are typically seen in immunocompromised hosts and manifest most commonly as cutaneous or subcutaneous disease. Systemic infections are exceedingly rare and associated with significant morbidity and mortality CASE PRESENTATION: A 28-year-old female originally from India presented with fevers, chills, weight loss and increasing back pain. Read More

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June 2018
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Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis.

Int J Environ Res Public Health 2018 May 26;15(6). Epub 2018 May 26.

Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45219, USA.

This study aimed to determine if short-term exposure to particulate matter (PM) and ozone (O₃) is associated with increased symptoms or lung function decline in fibrotic sarcoidosis. Sixteen patients with fibrotic sarcoidosis complicated by frequent exacerbations completed pulmonary function testing and questionnaires every three months for one year. We compared 7-, 10-, and 14-day average levels of PM and O₃ estimated at patient residences to spirometry (forced expiratory volume in 1 s (FEV1), to forced vital capacity (FVC), episodes of FEV1 decline > 10%) and questionnaire outcomes (Leicester cough questionnaire (LCQ), Saint George Respiratory Questionnaire (SGRQ), and King's Sarcoidosis Questionnaire (KSQ)) using generalized linear mixed effect models. Read More

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Active cardiac sarcoidosis on standard chest computed tomography.

Eur Heart J Cardiovasc Imaging 2018 May 30. Epub 2018 May 30.

King's College London & Guy's and St Thomas' PET Centre, Westminster Bridge road, London SE1 7EH, UK.

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May 2018
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A sarcoidosis clinician's perspective of MHC functional elements outside the antigen binding site.

Authors:
Marc A Judson

Hum Immunol 2018 May 30. Epub 2018 May 30.

Division of Pulmonary and Critical Care Medicine, Albany Medical College, MC-91; 47 New Scotland Ave., Albany, NY 10028, USA. Electronic address:

Sarcoidosis is a multisystem granulomatous disease of unknown cause. Evidence supports an integral role for interactions at the MHC binding site in the development of sarcoidosis. However, despite this evidence, there are clinical data that suggest that additional mechanisms are involved in the immunopathogenesis of this disease. Read More

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The Odd Gallbladder-a Rare Case of Gallbladder and Lymph Node Sarcoidosis: a Case Report and Review of the Literature.

J Gastrointest Cancer 2018 Jun 2. Epub 2018 Jun 2.

Department of General Surgery, Changi General Hospital, Singapore, Singapore.

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Clinical features of sarcoidosis associated pulmonary hypertension: Results of a multi-national registry.

Respir Med 2018 Jun 5;139:72-78. Epub 2018 May 5.

INOVA Medical Center, Fairfax, VA, USA.

Background: Pulmonary hypertension (PH) is a significant cause of morbidity and mortality in sarcoidosis. We established a multi-national registry of sarcoidosis associated PH (SAPH) patients.

Methods: Sarcoidosis patients with PH confirmed by right heart catheterization (RHC) were studied. Read More

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June 2018
1 Read

Three Cases of Scalp Sarcoidosis with Alopecia.

Actas Dermosifiliogr 2018 May 29. Epub 2018 May 29.

Departamento de Dermatología, Universidad de Medicina de Fukushima, Fukushima, Japón.

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Prognostic significance of ventricular late potentials in patients with pulmonary sarcoidosis.

Heart Rhythm 2018 Jun;15(6):798-802

Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.

Background: Early detection of cardiac involvement in sarcoidosis is difficult but essential to achieve optimal treatment. Signal-averaged electrocardiography (SAECG) can detect subtle cardiac electrical abnormalities termed late potentials (LPs) and would be useful for the early diagnosis of cardiac involvement.

Objective: This study aims to investigate the prognostic significance of LP in patients with pulmonary sarcoidosis. Read More

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Gallium-68 DOTA-NOC PET/CT as an alternate predictor of disease activity in sarcoidosis.

Nucl Med Commun 2018 May 30. Epub 2018 May 30.

Nuclear Medicine.

Introduction: We evaluated the role of gallium-68-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-Nal3-octreotide (Ga-DOTA-NOC) PET/CT in assessing sarcoidosis disease activity.

Patients And Methods: Patients diagnosed with sarcoidosis underwent Ga-DOTA-NOC-PET/CT. The maximum standardized uptake value (SUVmax) at the pathological site and in the descending thoracic aorta (reference standard, SUVmed) were assessed. Read More

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Sarcoid-resembling granulomatous lung disease secondary to occupational magnetite iron dust exposure.

Respirol Case Rep 2018 Aug 17;6(6):e00331. Epub 2018 May 17.

Respiratory Medicine Royal Darwin Hospital Darwin Australia.

Non-caseating granulomatous pulmonary conditions resembling sarcoidosis secondary to industrial/occupation exposure to magnetite iron ore dusts have been rarely documented in the literature. This is a case report of a 58-year-old blast crew member involved in iron ore/magnetite mining who presented with a 12-month history of chronic dry cough. High-resolution computed tomography revealed bilateral interstitial opacities. Read More

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Consumption Junction: A Case of Peritoneal Tuberculosis-induced Small Bowel Obstruction.

Clin Pract Cases Emerg Med 2018 Feb 11;2(1):51-54. Epub 2018 Jan 11.

Naval Medical Center San Diego, Department of Emergency Medicine, San Diego, California.

The rapid diagnosis and treatment of tuberculosis (TB) is necessary to prevent the spread of infection to others and reduce morbidity and mortality. Atypical presentations are not often considered in the differential. This patient presented with fever and abdominal pain. Read More

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February 2018

Atypical sarcoidosis-associated uveitis: diagnostic challenges.

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Ophthalmology, Manchester Royal Eye Hospital and Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

Sarcoidosis is a multisystem disease of unknown aetiology with pulmonary involvement in most patients. Uveitis is common and often characteristic. We report a case of ocular sarcoidosis with grossly atypical contiguous optic neuropathy and choroiditis and describe the diagnostic challenges in this highly unusual presentation. Read More

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May 2018
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The Etiology of Intraocular Inflammation in HIV Positive and HIV Negative Adults at a Tertiary Hospital in Cape Town, South Africa.

Ocul Immunol Inflamm 2018 May 30:1-8. Epub 2018 May 30.

d Department of Medical Microbiology , University Medical Center Utrecht , Utrecht , The Netherlands.

Purpose: To describe the patterns of uveitis in South Africa.

Methods: Prospective cross-sectional study.

Results: One hundred and six patients were enrolled and 37. Read More

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May 2018
3 Reads

Symptomatic muscular sarcoidosis: Lessons from a nationwide multicenter study.

Neurol Neuroimmunol Neuroinflamm 2018 May 16;5(3):e452. Epub 2018 Mar 16.

AP-HP (F.C.A., S.A, J.H., A.M., M.P., Z.A), Service de Médecine Interne 2, Institut e3m, Hôpital de la Pitié-Salpêtrière, Centre National de Référence Maladies Systémiques Rares, Lupus, Syndrome des anticorps antiphospholipides; Université Paris VI (F.C.A., J.H., O.B.), UPMC, Sorbonnes Universités; AP-HP (T.M.), Département de neurophysiologie et de neuropathologie, Hôpital de la Pitié-Salpêtrière, Paris; Service de Pneumologie (V.C.), Centre des maladies pulmonaires rares, Lyon; AP-HP (T.P.), Service de Médecine Interne, Hôpital Bichat; AP-HP (L.G., B.H., O.B., Z.A.), Service de Médecine Interne et immunologie clinique, Hôpital de la Pitié-Salpêtrière, Paris; AP-HP (M.S.), Service de Médecine Nucléaire, Hôpital Avicenne, Bobigny; Service de Médecine Interne (P.M.), CHU Bordeaux, Bordeaux; AP-HP (H.N., D.V.), Service de Pneumologie, Hôpital Avicenne, Bobigny, France.

Objectives: To describe clinicopathologic features of muscular sarcoidosis and the associated sarcoidosis phenotype through a nationwide multicenter study.

Methods: Patients were included if they had histologically proven sarcoidosis and symptomatic muscular involvement confirmed by biological, imaging, or histologic examinations.

Results: Forty-eight patients (20 males) were studied, with a median age at muscular symptoms onset of 45 years (range 18-71). Read More

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