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    Coexisting Systemic Sclerosis-Polymyositis and Sarcoidosis: Case Report and Review of the Literature.
    J Clin Rheumatol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Medicine E Meir Medical Center, Kfar Saba Affiliated With the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Hematology Institute, Hillel Yaffe Medical Center, Hadera Affiliated With the Rappaport Faculty of Medicine Technion Institute of Technology, Haifa Department of Pathology, Meir Medical Center, Kfar Saba, Affiliated With the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Department of Medicine E Meir Medical Center, Kfar Saba Affiliated With the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv

    Tidsskr Nor Laegeforen 2018 Feb 19. Epub 2018 Feb 19.
    Sarcoidosis is characterised by granulomatous inflammation in one or more organs, including the heart. Cardiac sarcoidosis generally has non-specific symptoms, and the disease is often diagnosed at a late stage. The condition is associated with cardiomyopathy and arrhythmia and may be fatal. Read More

    Dexamethasone Inserts in Noninfectious Uveitis: A Single-Center Experience.
    Ophthalmology 2018 Feb 16. Epub 2018 Feb 16.
    Charité - Department of Ophthalmology, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:
    Purpose: To report the effectiveness of repeated intravitreal dexamethasone (DEX) inserts in noninfectious uveitis patients.

    Design: Prospective, single-center, interventional clinical trial between February 2010 and March 2015.

    Participants: Patients with noninfectious uveitis with cystoid macular edema and/or vitreitis. Read More

    Differences Between Patients With Sarcoidosis With and Without Joint Involvement Treated for Fifteen Years in a Third Level Hospital.
    Reumatol Clin 2018 Feb 15. Epub 2018 Feb 15.
    Sección de Reumatología, Departamento de Medicina Interna, Hospital Pablo Tobón Uribe, Medellín, Colombia.
    Introduction: Sarcoidosis is a complex disease of unknown etiology, with a variable course and highly different forms of presentation. Our objective was to characterize all our patients with sarcoidosis with emphasis on their clinical presentation and to establish differences between patients with sarcoidosis with and without joint involvement.

    Methods: We reviewed the medical records of all patients with a diagnosis of sarcoidosis who were treated at the outpatient or inpatient services of the Pablo Tobón Uribe Hospital in Medellín, Colombia, from January 2002 to April 2017. Read More

    The effect of anti-tumor necrosis factor alpha agents on the outcome in pediatric uveitis of diverse etiologies.
    Graefes Arch Clin Exp Ophthalmol 2018 Feb 18. Epub 2018 Feb 18.
    Department of Ophthalmology, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel.
    Purpose: This study aimed to report the clinical outcome of children with uveitis treated with anti-tumor necrosis factor alpha (TNF-α) agents.

    Methods: This included a retrospective cohort study. Children with uveitis treated with infliximab or adalimumab in 2008-2014 at five dedicated uveitis clinics were identified by database search. Read More

    Clinical Features of Extrapulmonary Sarcoidosis without Lung Involvement.
    Chest 2018 Feb 14. Epub 2018 Feb 14.
    Albany Medical Center, Albany, NY.
    Background: Compared to pulmonary sarcoidosis, sarcoidosis without lung involvement may involve other immunopathologic mechanisms and be associated with other demographic and clinical features.

    Methods: This was a retrospective analysis of clinical data collected in real time on 1,686 patients with biopsy-proven sarcoidosis from two large university sarcoidosis outpatient clinics in the United States. We compared differences in demographics characteristics and clinical presentation between pulmonary and non-pulmonary sarcoidosis (NPS). Read More

    Pulmonary sarcoidosis with and without extrapulmonary involvement: a cross-sectional and observational study in China.
    BMJ Open 2018 Feb 16;8(2):e018865. Epub 2018 Feb 16.
    Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
    Objectives: Sarcoidosis is a multisystem disease characterised by the formation of granulomas within various organs, mainly the lungs. Several studies from different countries have been undertaken to investigate sarcoidosis with extrapulmonary involvement except from China. The objective of this study is to investigate a comparative clinical analysis in patients with pulmonary sarcoidosis with and without extrapulmonary involvement from China. Read More

    Parotid gland involvement in Heerfordt syndrome: a case report.
    Pathologica 2017 Dec;109(4):418-420
    Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Italy.
    Sarcoidosis is a multisystemic granulomatous disease characterized by the presence of noncaseating granulomas, the exact etiology of which is yet to be determined. Most of patients show granulomas located in the lungs or in the related lymph nodes. However, lesions can affect any organ. Read More

    Increased T helper 17.1 cells in sarcoidosis mediastinal lymph nodes.
    Eur Respir J 2018 Feb 15. Epub 2018 Feb 15.
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    The lung-draining mediastinal lymph nodes (MLN) are currently widely used to diagnose sarcoidosis. We previously reported that T helper 17.1 (Th17. Read More

    Orthopaedic Considerations in the Management of Skeletal Sarcoidosis.
    J Am Acad Orthop Surg 2018 Feb 13. Epub 2018 Feb 13.
    From the Department of Orthopaedic Surgery, Musculoskeletal Oncology Division, Massachusetts General Hospital, Boston, MA (Dr. Crawford and Dr. Lozano Calderón), the Department of Orthopaedic Surgery (Dr. Crawford) and the Department of Rheumatology (Dr. Badlissi), Beth Israel Deaconess Medical Center, Boston, and the Department of Orthopaedic Surgery, Boston Children's Hospital, Boston (Dr. Crawford).
    Advanced imaging has demonstrated that musculoskeletal manifestations of systemic sarcoidosis are more common than previously thought. A definitive strategy for the management of osseous sarcoidosis has not been defined. Some lesions resolve spontaneously, and no systemic medication for sarcoidosis consistently resolves lesions. Read More

    Underexpression of miR-486-5p but not Overexpression of miR-155 is Associated with Lung Cancer Stages.
    Microrna 2018 Feb 12. Epub 2018 Feb 12.
    Faculty of Engineering - Pharos University in Alexandria. Egypt.
    Background: Evidence is increasing that microRNAs (miR) are particularly important in lung homeostasis and development and have been shown to be involved in many pulmonary diseases such as asthma, chronic obstructive pulmonary disease, sarcoidosis, lung cancer (LC) and other smoking-related diseases.

    Objective: The objective of this study was to investigate the expression of miR-155 and miR-486-5p in tissues from LC patients and healthy endobronchial mucosa as prognostic biomarkers for diagnosing LC.

    Methods: Bronchoscopic and thoracoscopic tissue biopsies were taken from 50 LC patients and other 50 control subjects without lung mass, who were planned for a clinical bronchoscopy. Read More

    The Syndrome of Tubulointerstitial Nephritis With Uveitis (TINU).
    Am J Kidney Dis 2018 Feb 8. Epub 2018 Feb 8.
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA.
    The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a multisystemic autoimmune disorder that may occur in response to various environmental triggers, including drugs and microbial pathogens. Evidence exists of HLA antigen-related genetic predisposition to developing TINU. The resulting inflammation affects chiefly the ocular uvea and renal tubules, although other organs may be involved. Read More

    Contribution of diagnostic tests for the etiological assessment of uveitis, data from the ULISSE study (Uveitis: Clinical and medicoeconomic evaluation of a standardized strategy of the etiological diagnosis).
    Autoimmun Rev 2018 Feb 7. Epub 2018 Feb 7.
    Hospices Civils de Lyon, Croix-Rousse Hospital, Department of Internal Medicine, Lyon, France.
    Purpose: ULISSE is the only study that prospectively assessed the efficiency of a standardized strategy, compared to an open strategy for the etiologic diagnosis of uveitis. Our aim was to evaluate the diagnostic yield of the tests prescribed in the ULISSE study to clarify their relevance.

    Methods: ULISSE is a non-inferiority, prospective, multicenter and cluster randomized study. Read More

    Lung health in era of climate change and dust storms.
    Environ Res 2018 Feb 6;163:36-42. Epub 2018 Feb 6.
    Division of Pulmonary and Critical Care, University of Miami, Miami, FL, United States; Miami VA Healthcare System, Miami, FL, United States. Electronic address:
    Dust storms are strong winds which lead to particle exposure over extensive areas. These storms influence air quality on both a local and global scale which lead to both short and long-term effects. The frequency of dust storms has been on the rise during the last decade. Read More

    Optimized angiotensin-converting enzyme activity assay for the accurate diagnosis of sarcoidosis.
    Clin Chem Lab Med 2018 Feb 9. Epub 2018 Feb 9.
    Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
    Background: Serum angiotensin-converting enzyme (ACE) activity determination can aid the early diagnosis of sarcoidosis. We aimed to optimize a fluorescent kinetic assay for ACE activity by screening the confounding effects of endogenous ACE inhibitors and interfering factors. Genotype-dependent and genotype-independent reference values of ACE activity were established, and their diagnostic accuracies were validated in a clinical study. Read More

    Clinical features and prognostic significance of splenic involvement in sarcoidosis.
    Monaldi Arch Chest Dis 2017 Dec 21;87(3):893. Epub 2017 Dec 21.
    Pulmonary Diseases Department, Cerrahpasa Medical Faculty, Istanbul University.
    Sarcoidosis is a systemic disease characterized by noncasefied granulomas in various organs. Incidence of splenic disease is variable and is reported to occur in 6.7 to 77 percent of the patients. Read More

    Association of HLA antigens with the clinical course of sarcoidosis and familial disease.
    Monaldi Arch Chest Dis 2017 Sep 27;87(3):835. Epub 2017 Sep 27.
    Istanbul University, Department of Internal Medicine.
    Patients with sarcoidosis usually have a benign course and a favourable prognosis. Although spontaneous remission is common, a progressive disease with a severe prognosis occurs in a small but significant number of patients. The aim of this study was to evaluate the potential significance of HLA antigens as a clinical marker on the outcome of sarcoidosis patients. Read More

    A case of longitudinal care of a patient with cardiac sarcoidosis.
    J Nucl Cardiol 2018 Feb 8. Epub 2018 Feb 8.
    Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
    Cardiac sarcoidosis has long been an evasive diagnosis with a spectrum of clinical presentations that extend from asymptomatic to ventricular arrhythmias and sudden cardiac death. The diagnosis has traditionally relied on histology which suffers from the low sensitivity of endomyocardial biopsy due to the patchy nature of the disease in addition to its invasive nature. Due to significant advancements in imaging, it is now possible to accurately identify cardiac sarcoidosis using non-invasive imaging modalities even without histological confirmation. Read More

    Spectrum of interstitial lung diseases at a tertiary center in a developing country: A study of 803 subjects.
    PLoS One 2018 8;13(2):e0191938. Epub 2018 Feb 8.
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: The spectrum of interstitial lung diseases (ILDs) have mainly been reported from the developed countries; data from developing countries is sparse and conflicting. The aim of this study is to describe the distribution of various ILDs from a developing country.

    Methods: This is an analysis of prospectively collected clinical, radiological and histological data of consecutive subjects (age >12 years) with ILDs from a single tertiary care medical center. Read More

    Role of CT Chest and Cytology in Differentiating Tuberculosis from Presumed Sarcoidosis in Uveitis.
    Ocul Immunol Inflamm 2018 Feb 8:1-8. Epub 2018 Feb 8.
    b Departments of Pulmonary Medicine , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
    Purpose: To report the role of CT chest and cytology in suspected tubercular and sarcoid uveitis.

    Methods: This is a retrospective, interventional case series of 376 uveitis patients with suspected ocular tuberculosis (TB)/sarcoidosis seen between January 2010 and April 2015 at the Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh. All underwent CT chest, and had following inclusion criteria: (1) Presence of active granulomatous anterior/intermediate/posterior uveitis or panuveitis; (2) a documented tuberculin skin test/QuantiFERON-TB Gold test; (3) all other causes of infectious/non-infectious uveitis ruled out. Read More

    Increased Aqueous Humor CD4+/CD8+ Lymphocyte Ratio in Sarcoid Uveitis.
    Ocul Immunol Inflamm 2018 Feb 8:1-8. Epub 2018 Feb 8.
    b GROW Research Laboratory , Narayana Nethralaya Foundation , Bangalore , India.
    Purpose: To determine aqueous humor CD4+/CD8+ T-lymphocyte ratio changes in sarcoid and non-sarcoid uveitis with anterior chamber involvement.

    Methods: The case-control study includes 61 patients with either anterior uveitis, intermediate uveitis with anterior spill, or panuveitis. A total of 21 of them were categorized as sarcoid uveitis and 40 as non-sarcoid uveitis according to diagnostic criteria. Read More

    Granulomatous Tattoo reaction with Associated Uveitis successfully treated with methotrexate.
    J Eur Acad Dermatol Venereol 2018 Feb 8. Epub 2018 Feb 8.
    Academic Tattoo Clinic Amsterdam Department of Dermatology-Allergology, VU University Medical Center, Amsterdam, the Netherlands.
    Few reports describe tattoo granulomas with the simultaneous development of intraocular inflammation without any evidence of systemic sarcoidosis at the time of presentation. Here, we present a patient with no prior diagnosis of sarcoidosis who developed inflammation of tattooed skin and shortly after bilateral uveitis.A 52-year-old previously healthy woman presented with a 8 months history of swelling and itching located in all of her 11 black tattoos. Read More

    Annular cutaneous sarcoidosis with systemic involvement.
    J Family Med Prim Care 2017 Jul-Sep;6(3):660-662
    Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.
    Sarcoidosis is a granulomatous disease involving multiple systems. Cutaneous involvement is present in 25% of patients. A 42-year-old woman presented with itchy skin lesions on her face for 5 years duration. Read More

    Association of genetic variants inandwith uveitis in sarcoidosis.
    Mol Vis 2018 21;24:59-74. Epub 2018 Jan 21.
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA.
    Purpose: Uveitis occurs in a subset of patients with sarcoidosis. The purpose of this study was to determine whether genetic variants that have been associated previously with overall sarcoidosis are associated with increased risk of developing uveitis.

    Methods: Seventy-seven subjects were enrolled, including 45 patients diagnosed with sarcoidosis-related uveitis as cases and 32 patients with systemic sarcoidosis without ocular involvement as controls. Read More

    Endobronchial Ultrasound (EBUS) - Update 2017.
    Ultraschall Med 2018 Feb 7;39(1):14-38. Epub 2018 Feb 7.
    Endobronchial ultrasound (EBUS) has revolutionized the diagnosis of lung cancer over the last decade. This minimally invasive diagnostic method has also become increasingly important in the case of other diseases such as sarcoidosis, thereby helping to avoid unnecessary diagnostic interventions. This review article provides an update regarding EBUS and discusses current and future developments of this method. Read More

    [Association of FOXP3 gene -3279 C>A polymorphism with the risk of pulmonary sarcoidosis].
    Ter Arkh 2017 ;89(12):64-67
    V.A. Baranov Republican Hospital, Petrozavodsk, Russia.
    Aim: To investigate the association of the polymorphic marker -3279 C>A of the FOXP3 gene with the risk of pulmonary sarcoidosis (PS) and to estimate the transcription level of this gene in the carriers of different genotypes of this polymorphic marker.

    Subjects And Methods: The investigation included 99 patients of Russian ethnicity (mean age, 45.41±1. Read More

    Comprehensive analysis of immune, extracellular matrices and pathogens profile in lung granulomatosis of unexplained etiology.
    Hum Pathol 2018 Feb 2. Epub 2018 Feb 2.
    Department of Pathology, Faculty of Medicine, University of Sao Paulo, São Paulo, Brazil. Electronic address:
    This study analyzed the Type 1 and Type 2T helper (Th-1/Th-2) cytokines (including interleukins), immune cellular, matrix profile and pathogens in granulomas with unexplained etiology and compared to infectious and non-infectious etiology. Surgical lung biopsies from 108 patients were retrospectively reviewed. Histochemistry, immunohistochemistry, immunofluorescence, morphometry and polymerase chain reaction (PCR) were employed, respectively, to evaluate total collagen and elastin fibers, collagen I and III, immune cells, cytokines, metalloproteinase-9 (MMP-9), myofibroblasts and multiple usual and unusual pathogens. Read More

    Cardiac Sarcoidosis: A Review of Contemporary Challenges in Diagnosis and Treatment.
    Am J Med Sci 2018 Feb 18;355(2):113-125. Epub 2017 Aug 18.
    Sarcoidosis is a systemic disease characterized by noncaseating granulomas and is often a diagnosis of exclusion. The actual prevalence of cardiac sarcoidosis (CS) is unknown, as studies have demonstrated mixed data. CS may be asymptomatic and is likely more frequently encountered than previously thought. Read More

    A case of cardiac sarcoidosis mimicking cardiac amyloidosis on cardiovascular magnetic resonance.
    ESC Heart Fail 2018 Feb 5. Epub 2018 Feb 5.
    Department of Cardiology and Nuclear Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
    A 52-year-old male visited our hospital with abnormal electrocardiogram and exertional fatigue. The electrocardiogram showed first-degree atrioventricular block, complete right bundle branch block, and inverted T waves in Leads II, III, aVF, V3, and V4. Echocardiography showed biventricular wall thickening involving granular sparkling of the interventricular septum. Read More

    Granulomatous diseases of the breast and axilla: radiological findings with pathological correlation.
    Insights Imaging 2018 Feb 5. Epub 2018 Feb 5.
    Department of Radiology, Mayo Clinic, Rochester, MN, USA.
    Objectives: This article reviews our experience and describes the literature findings of granulomatous diseases of the breast and axilla.

    Methods: After approval of the Institutional Review Board was obtained, the surgical pathological records from January 2000 to January 2017 were searched for the keyword granulomatous. Clinical, imaging and histology findings were reviewed by both a fellowship-trained radiologist and a breast-imaging consultant radiologist, reviewing 127 patients (age range, 32-86 years; 126 women and 1 man). Read More

    A Prospective Review of the Results of Patients Treated and Followed up for a Diagnosis of Sarcoidosis.
    Turk Thorac J 2018 Jan 27;19(1):1-6. Epub 2017 Sep 27.
    Department of Chest Diseases, İskenderun State Hospital, Hatay, Turkey.
    Objectives: The present study reports the treatment and follow-up results of patients prospectively diagnosed and treated in a public hospital.

    Material And Methods: The present study reports the prospective follow-up data of 21 sarcoidosis cases followed up and treated in the Department of Chest Diseases of Dörtyol State Hospital from January 2010 to December 2014.

    Results: The 21 cases had a mean age of 44±10 years and a mean follow-up period of 38±13 months. Read More

    Propionibacterium acnes-derived insoluble immune complexes in sinus macrophages of lymph nodes affected by sarcoidosis.
    PLoS One 2018 5;13(2):e0192408. Epub 2018 Feb 5.
    Department of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
    Background: Propionibacterium acnes is thought to be a causative agent of sarcoidosis. Patients with sarcoidosis have circulating immune complexes. We attempted to detect P. Read More

    Efficacy of a Structured Exercise Program for Improving Functional Capacity and Quality of Life in Patients With Stage 3 and 4 Sarcoidosis: A RANDOMIZED CONTROLLED TRIAL.
    J Cardiopulm Rehabil Prev 2018 Mar;38(2):124-130
    Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Izmir Katip Celebi University, Izmir, Turkey (Dr Naz), Dokuz Eylul University, School of Physical Therapy and Rehabilitation, Izmir, Turkey (Dr Ozalevli); and Dr Suat Seren Chest Disease and Thoracic Surgery Training and Research Hospital, Izmir, Turkey (Drs Ozkan and Sahin).
    Purpose: This study investigated the effects of an exercise program on functional capacity and quality of life in patients with stage 3 and stage 4 sarcoidosis.

    Methods: Eighteen patients with stage 3 and 4 sarcoidosis were recruited; 9 received 12 wk of supervised exercise training and 9 received usual care. Patients underwent the following evaluations at baseline and follow-up: 6-min walk test, maximal inspiratory and expiratory pressure tests, back and leg dynamometer test, modified Medical Research Council Dyspnea Scale, Fatigue Severity Scale, St George Respiratory Questionnaire, Short Form-36 Quality of Life Questionnaire, Hospital Anxiety and Depression Questionnaire, body plethysmography, carbon monoxide diffusing capacity test, and blood gas analysis. Read More

    Dynamic changes of sarcoidosis presenting as acquired ichthyosiform erythroderma.
    Eur J Dermatol 2018 Feb 1. Epub 2018 Feb 1.
    Department of Dermatology, Tianjin Medical University General Hospital, Tianjin, 300052, PR China, Tianjin Neurological Institute, Key Laboratory of Post-neurotrauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, 154 Anshan Road, Tianjin 300052, China.

    [Management of orbital inflammation in internal medicine. Proposal for a diagnostic work-up].
    Rev Med Interne 2018 Feb 1. Epub 2018 Feb 1.
    Service de médecine interne, hôpital de la Croix-Rousse, hospices Civils de Lyon, université de Lyon, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France. Electronic address:
    Inflammatory orbitopathies relate to an inflammatory state originating within the orbit and its adnexes, except the inner ocular globe. Orbital inflammation (OI) may be either localized manifestation of a proven or like autoimmune disease, or local response from immune system against infectious, structural or tumoral antigens. We review the clinical manifestations of OI, which provide helpful clues to the diagnosis and describe the inflammatory, infectious and neoplastic conditions classically associated with OI. Read More

    [Endobronchial ultrasound with transbronchial needle aspiration: Evaluation of clinical practice].
    Rev Mal Respir 2018 Jan 23. Epub 2018 Jan 23.
    Service de pneumologie et réanimation respiratoire, CHU Amiens-Picardie, 80054 Amiens cedex 1, France.
    Introduction: Endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) has undergone a large increase in France since 2007. The aim is to study the evolution of the indications for EBUS-TBNA in our region during the period 2008-2013.

    Material And Methods: We conducted a retrospective observational study including all the patients who underwent an EBUS-TBNA procedure in Picardie from 2008 to 2013. Read More

    Endobronchial Mucosal Neuroma with Sarcoidosis.
    J Coll Physicians Surg Pak 2018 Feb;28(2):162-163
    Department of Pulmonary Medicine, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.
    A first case of endobronchial mucosal neuroma with sarcoidosis is hereby reported. A 67-year female patient, who was diagnosed as sarcoidosis previously, was admitted to our hospital with symptoms of dyspnea, chest pain and fatigue. Middle lobe atelectasis and endobronchial lesion were observed in thorax computed tomography (CT). Read More

    [Early Gastric Cancer with Many Enlarged Lymph Nodes as Sarcoid Reaction - A Case Report].
    Gan To Kagaku Ryoho 2017 Nov;44(12):2020-2022
    Dept. of Surgery, Yujinkai Yamazaki Hospital.
    The patient was a 57-year-old man. Upper gastrointestinal endoscopy revealed a 0- II c lesion at the anterior wall of the greater curvature in the lower third of the stomach, and the biopsy of this tumor gave the diagnosis of tubular adenocarcinoma. Abdominal contrast-enhanced computed tomography revealed many enlarged regional and non-regional lymph nodes. Read More

    [A Case of Pancreatic Cancer with Multiple Lymph Node Swelling Caused by Sarcoidosis].
    Gan To Kagaku Ryoho 2017 Nov;44(12):1886-1888
    Dept. of Surgery, Konan Hospital.
    A 69-year-old woman who was identified the tumor of the pancreas tail by CT scan for postoperative inspection of breast cancer. Pancreas tail cancer with para-aortic lymph node metastases was diagnosed by close inspection. She consulted a different hospital to receive their second opinion. Read More

    Current management of sarcoidosis I: pulmonary, cardiac, and neurologic manifestations.
    Curr Opin Rheumatol 2018 Jan 31. Epub 2018 Jan 31.
    Department of Medicine, University of Colorado School of Medicine, Division of Rheumatology, Aurora, Colorado, USA.
    Purpose Of Review: Sarcoidosis is a systemic disease characterized by noncaseating granulomatous inflammation of multiple organ systems. Pulmonary, cardiac, and neurologic involvements have the worst prognosis. Current recommendations for the therapeutic management and follow-up of sarcoidosis involving these critical organs will be reviewed. Read More

    Unexplained cough: it is time to rule out Sjogren's syndrome.
    Clin Rheumatol 2018 Jan 31. Epub 2018 Jan 31.
    The Pulmonary Medicine Institute, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel.
    Sjogren's syndrome is associated with chronic cough, but sicca symptoms are missing from cough evaluation guidelines. We evaluated patients with unexplained cough for undiagnosed Sjogren's syndrome. Patients referred to our pulmonary clinic (Sheba Medical Center, 2009 to 2012) with unexplained cough and concomitant dry eyes were selected for evaluation. Read More

    Sarcoidosis and spondyloarthritis: A coincidence or common etiopathogenesis?
    Caspian J Intern Med 2018 ;9(1):100-103
    Department of Rheumatology, Kassab Institute of Orthopedics, Manouba. Tunisia.
    Background: Sarcoidosis is a multisystem granulomatous disease. Co-existence with spondyloarthritis (SA) has been more described as an adverse effect of anti-TNF α therapy than an association. We report herein a case of a typical sarcoidosis confirmed by histological proofs and an advanced SA with a bamboo column. Read More

    Is there a clinical usefulness for radiolabeled somatostatin analogues beyond the consolidated role in NETs?
    Indian J Radiol Imaging 2017 Oct-Dec;27(4):509-516
    Nuclear Medicine Unit, Department of Clinical and Experimental Medicine, F. Magrassi, A. Lanzara, Seconda Università di Napoli, Napoli, Italy.
    The somatostatin (SS) receptor scintigraphy (SRS), using octreotide radiolabelled withIn (Ocreoscan©, OCT), is a consolidated diagnostic procedure in patients with neuroendocrine tumors (NET) because of an increased expression of somatostatin receptors (SS-R) on neoplastic cells. Uptake of SS analogues (SSA) can also be due to SS-R expression on nonmalignant cells when activated as lymphocytes, macrophages, fibroblasts, vascular cells. Because of this uptake, clinical indications can be found either in neoplasms not overexpressing SS-R, as nonsmall cell lung cancer, and in active benign diseases. Read More

    Dilemma of diagnosing thoracic sarcoidosis in tuberculosis-endemic regions: An imaging-based approach. Part 2.
    Indian J Radiol Imaging 2017 Oct-Dec;27(4):380-388
    Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
    The second part of the review discusses the role of different existing imaging modalities in the evaluation of thoracic sarcoidosis, including chest radiograph, computed tomography, magnetic resonance imaging, endobronchial ultrasound, and positron emission tomography. While summarizing the advantages and pitfalls of each imaging modality, the authors propose imaging recommendations and an algorithm to be followed in the evaluation of clinically suspected case of sarcoidosis in tuberculosis-endemic regions. Read More

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