60,481 results match your criteria Salud i Ciencia Health i Science [Journal]

Targeting STATs in neuroinflammation: the Road Less Traveled!

Pharmacol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

JAK/STAT transduction pathway is a highly conserved pathway implicated in regulating cellular proliferation, differentiation, survival and apoptosis. Dysregulation of this pathway is involved in the onset of autoimmune, haematological, oncological, metabolic and neurological diseases. Over the last few years, the research of anti-neuroinflammatory agents has gained considerable attention. Read More

View Article
December 2018

Neonatal exposure to a glyphosate-based herbicide alters the histofunctional differentiation of the ovaries and uterus in lambs.

Mol Cell Endocrinol 2018 Dec 11. Epub 2018 Dec 11.

Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquímica y Ciencias Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional del Litoral, Santa Fe, Argentina. Electronic address:

The aim of the present study was to compare the effect of oral and subcutaneous exposure to a glyphosate-based herbicide (GBH) on the female reproductive system, specifically in the ovaries and uterus of prepubertal lambs. To this end, ewe lambs were exposed to a s.c. Read More

View Article
December 2018

Mortality of patients with chronic disease: an increasing problem.

J Pediatr (Rio J) 2018 Dec 11. Epub 2018 Dec 11.

Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria, Pediatric Intensive Care Unit, Madrid, Spain; Maternal and Child Health and Development Network, RETICS funded by the PN I+D+I 2013-2016 (Spain), ISCIII-Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (ERDF), Spain; Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Salud Pública y Maternoinfantil, Madrid, Spain. Electronic address:

View Article
December 2018

Interventions to treat cutaneous leishmaniasis in children: A systematic review.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006986. Epub 2018 Dec 14.

Unidad Clínica de Leishmaniasis, Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.

Background: Case management in children with cutaneous leishmaniasis (CL) is mainly based on studies performed in adults. We aimed to determine the efficacy and harms of interventions to treat CL in children.

Methods: We conducted a systematic review of clinical trials and cohort studies, assessing treatments of CL in children (≤12 years old). Read More

View Article
December 2018
1 Read

[Jesús Kumate 1924-2018].

Jaime Sepúlveda

Salud Publica Mex 2018 Sep-Oct;60(5):605-608

Director Ejecutivo. UCSF Institute for Global Health Sciences. Discurso pronunciado en el Instituto Nacional de Salud Pública; 22 de mayo de 2018.

View Article
December 2018

[New tobacco products, a threat for tobacco control and public health of Mexico].

Salud Publica Mex 2018 Sep-Oct;60(5):598-604

Departamento de Investigación sobre Tabaco, Instituto Nacional de Salud Pública. Cuernavaca, Morelos. México.

The new tobacco products that include electronic cigarettes (called "E Cig", "e-hookahs", "mods", "vape-pens"), electronic nicotine delivery systems (SEAN, Spanish acronym), similar systems without nicotine (SSSN, Spanish acronym) and alternative nicotine consumption systems (SACN, Spanish acronym), are positioned in the global market with a discourse of harm reduction and risk minimization. This manuscript summarizes the scientific evidence and presents a regulatory proposal for this technological innovation, oriented to guide the decision making of legislators, government institutions and organized civil society. The scientific evidence concludes that there is no safe tobacco product for health. Read More

View Article

[Position of the Latin American Society of Nutrition (SLAN) on the management of conflict of interest.]

Salud Publica Mex 2018 Sep-Oct;60(5):592-597

Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública. Cuernavaca, México.

There is solid evidence documenting relationships between the food and beverage industry and academia that shows that industry sponsored research is likely to bias results in favor of industry. In Latin America, examples of these situations have been documented in Mexico, Brazil, Chile, Peru, Colombia, and Ecuador, among others. Due to the urgent need for studying and managing relationships between the food and beverage industry and the field of health and nutrition research, in 2017, the President of the Latin American Society of Nutrition (SLAN) appointed a Conflict of Interest Committee (CCI). Read More

View Article

[Position paper on taxes to non-basic energy-dense foods and sugar-sweetened beverages].

Salud Publica Mex 2018 Sep-Oct;60(5):586-591

Dirección General, Instituto Nacional de Salud Pública. México.

In 2014 the Mexican government implemented taxes to reduce the consumption of sugar-sweetened beverages and nonessential energy-dense foods. In this manuscript, we analyze the scientific evidence linking the consumption of these products to chronic diseases, and summarize the studies that have evaluated the observed and expected impact of food taxes in Mexico. The implementation of taxes to unhealthy foods has reduced purchases of sugar-sweetened beverages in 7. Read More

View Article

Functional, nutritional and social factors associated with mobility limitations in the elderly: a systematic review.

Salud Publica Mex 2018 Sep-Oct;60(5):579-585

Postgraduate Program in Collective Health, Odontology Department, Federal University of Rio Grande do Norte. Natal, Brazil.

Objective: To systematically review the prevalence and incidence of mobility limitations in the elderly people and their associated factors.

Materials And Methods: Articles in the electronic literature were searched via PubMed, Scopus,,Lilacs, SciELO, PAHO, MedCarib, Repidisca, Wholis, IBCES, PEDro, Medline and Bireme (2012-2016). The instrument STROBE was used to analyze the quality of the work and the PRISMA recommendation was used to structure the review. Read More

View Article
September 2017

[Social determinants of the health of international migrant children in Chile: qualitative evidence.]

Salud Publica Mex 2018 Sep-Oct;60(5):566-578

Programa de Estudios Sociales en Salud, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo. Santiago, Chile.

Objective: To explore the social determinants of health (SDH) of international migrant children, from the perceptions of caregivers, health workers and local authorities in eight municipalities in Chile.

Materials And Methods: A secondary analysis of data was conducted from a qualitative study that took place between 2014 and 2017. The original study involved semi-structured interviews and focus groups. Read More

View Article

[Social participation and health: a collaborative experience on chronic kidney disease.]

Salud Publica Mex 2018 Sep-Oct;60(5):559-565

School of Kinesiology and Health Studies, Queen's University. Kingston, Canada.

Objective: To identify challenges derived from renal insufficiency, as well as potential solutions and an agenda for action.

Materials And Methods: y adopting a collaborative research approach, diverse stakeholders -sick people, family members, advocacy groups, health professionals, and academics- participated in two gatherings in the context of the World Kidney Day in Guadalajara, Mexico and created an agenda for action. Data was gathered through group discussions. Read More

View Article

Enhancing smoking cessation in Mexico using an e-Health tool in primary healthcare.

Salud Publica Mex 2018 Sep-Oct;60(5):549-558

Department of Biomedical Research, Medical Center, Hackensack University. Hackensack, NJ, US.

Objective: To evaluate an e-Health tool designed to enhance smoking cessation in Mexico in primary healthcare.

Materials And Methods: Smokers 18 years of age and older were recruited in the waiting room of two primary healthcare clinics in Mexico City. Participants used an eHealth smoking cessation tool that included smoking-related assessments, education on pharmacotherapy, and motivational videos. Read More

View Article
December 2017

[Validation of a short Spanish version of the instrument Barriers to Physical Activity Questionnaire for People with Mobility Impairments.]

Salud Publica Mex 2018 Sep-Oct;60(5):539-548

Departamento de Educación Física y Deportiva, Universitat de València. España.

Objective: To validate a short Spanish version of the instrument Barriers to Physical Activity Questionnaire for People with Mobility Impairments (BPAQ-MI), applicable to different types of disability.

Materials And Methods: The questionnaire was administered to 791 university students with disabilities. The factorial structure was validated by confirmatory factor analysis and Spearman correlations were carried out to assess criterion validity. Read More

View Article
February 2017

[Psychometric validation of an instrument to evaluate the context of quality improvement and accreditation of hospitals].

Salud Publica Mex 2018 Sep-Oct;60(5):528-538

Instituto Nacional de Salud Pública. México.

Objective: To adapt and validate an instrument to measure the context factors which favor quality improvement initiatives and accreditation of hospitals.

Materials And Methods: The model and questionnaire Model for Understanding Success in Quality (MUSIQ) is adapted and validated for application in Spanish-speaking countries and its specific use in hospital accreditation projects. The theoretical construct of its dimensions is assessed by confirmatory factor analysis (Bartlett test and Kaiser-Meyer-Olkim index) and internal consistency (Cronbach's a), in a study carried out in a sample of 54 hospitals of medium and high complexity in Colombia. Read More

View Article
October 2017

Dry eye symptoms and associated risk factors among adults aged 50 or more years in Central Mexico.

Salud Publica Mex 2018 Sep-Oct;60(5):520-527

Departamento de Epidemiología Ocular y Salud Visual, Instituto de Oftalmología Conde de Valenciana. Mexico City, Mexico.

Objective: To determine the prevalence of dry eye symptoms (DES) and associated risk factors among adults in Tlaxcala, Mexico.

Materials And Methods: A cross-sectional population-based study that included 1 508 individuals aged ≥50 years who answered the Dry Eye Questionnaire (DEQ5), with a score ranging between 0 and 22; the following categories were defined: no DES (<6); mild-moderate DES (6 to 11) and severe DES (≥12).

Results: The prevalence of DES was 41. Read More

View Article

[Food Insecurity Experience Scale (FIES) in Colombia, Guatemala, and México.]

Salud Publica Mex 2018 Sep-Oct;60(5):510-519

Hospital Universitario Nacional de Colombia, Facultad de Medicina, Universidad Nacional de Colombia. Bogotá. Colombia.

Objective: To compare the psychometric characteristics of the Food Insecurity Experience Scale (FIES) and the grade of similitude or difference among Colombia, Guatemala, and Mexico during three years.

Materials And Methods: Psychometric comparison using the Rasch model to calculate the relative severity of each item in FIES, INFIT and contrast in the Differential Functioning of Items (c-DIF).

Results: The majority of items showed a relative severity corresponding to the theoretical construct and acceptably fit the model (INFIT=0. Read More

View Article

[Development and validation of a screening score for prediabetes and undiagnosed diabetes.]

Salud Publica Mex 2018 Sep-Oct;60(5):500-509

Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Ciudad de México, México.

Objective: To develop and validate an easy-to-use risk score to detect prediabetes and undiagnosed diabetes in Mexican population.

Materials And Methods: Using information from the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán's cohort study of 10 234 adults, risk factors were identified and included in multiple logistic regression models stratified by sex. The beta coefficients of the final model were multiplied by 10, thus obtaining the weights of each variable in the score. Read More

View Article

La nueva oleada de la investigación en salud pública: de la evidencia a la política.

Salud Publica Mex 2018 Sep-Oct;60(5):498-499

Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, México.

View Article
December 2018

[Response to the letter "The analysis of inequalities in health"].

Salud Publica Mex 2018 Sep-Oct;60(5):496-497

Instituto Mexicano del Seguro Social. México.

View Article
December 2018

[The analysis of inequalities in health: comments to Julio Pisanty-Alatorre].

Salud Publica Mex 2018 Sep-Oct;60(5):495

Coordinación de Vigilancia Epidemiológica, Instituto Mexicano del Seguro Social. Ciudad de México,México.

View Article
December 2018

[The recent syndemic of HIV and injected drugs in Hermosillo, Sonora and how face it with a public policy of harm reduction].

Salud Publica Mex 2018 Sep-Oct;60(5):494-495

Centro Nacional para la Prevención y Control del VIH//Sida. Ciudad de México, México.

View Article
December 2018

[Anthropometric measures and their relationship with the polymorphism G-2548A of the LEP gene in obese women from Mexico].

Salud Publica Mex 2018 Sep-Oct;60(5):493-494

Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara. Guadalajara, México.

View Article
December 2018

[Consumption of psychoactive substances in students of San Juan del Río, Querétaro].

Salud Publica Mex 2018 Sep-Oct;60(5):492-493

Universidad Autónoma de Querétaro. Querétaro, México.

View Article
December 2018

[Characteristics of Mexico's return migration for health reasons, 2014-2016].

Salud Publica Mex 2018 Sep-Oct;60(5):489-491

Departamento de Estudios de Población, El Colegio de la Frontera Norte. Tijuana, Baja California, México.

View Article
December 2018

[Validation of the Cognitive Emotional Regulation Questionnaire in Mexican patients with breast cancer].

Salud Publica Mex 2018 Sep-Oct;60(5):488-489

Joven y Fuerte: Programa para la Atención e Investigación de Mujeres Jóvenes con Cáncer de Mama, Instituto Nacional de Cancerología. Ciudad de México.

View Article
December 2018

[Leucocyte esterase as a reliable diagnostic, cost-effective and fast in knee infections].

Acta Ortop Mex 2018 Jul-Aug;32(4):198-202

Dirección de Educación e Investigación en Salud, Hospital de Traumatología. Unidad Médica de Alta Especialidad (UMAE). «Dr. Victorio de la Fuente Narváez», Instituto Mexicano del Seguro Social (IMSS). Ciudad de México. México.

Background: The articular infection represents a challenge due to its complexity and its devastating effect when not treated promptly. We have various diagnostic studies: cultures, ESR, CRP, count of leukocytes, among others but none is specific, it takes more than 30 minutes to complete and require complex infrastructure. In this study we determine the sensitivity and specificity of the leukocyte esterase for detection of an infectious process joint in Mexican population. Read More

View Article
December 2018

A giant and atypical port-wine stain with facial deformity.

J Dtsch Dermatol Ges 2018 Dec 14. Epub 2018 Dec 14.

Servicio de Dermatología Hospital Universitario "Dr. José E. González", Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, México.

View Article
December 2018

Competing mortality in oropharyngeal carcinoma according to human papillomavirus status.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Otorhinolaryngology Department, Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: The objective of the present study is to assess differences in the competing causes of death in patients with oropharyngeal carcinoma (OPC) as a function of the human papillomavirus (HPV) status.

Methods: We studied retrospectively 423 patients with OPC with known HPV status. Among the patients included in the study, 53 (12. Read More

View Article
December 2018

Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1α expression in parasympathetic versus sympathetic paragangliomas.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Institute of Sanitary Research of Asturias, Institute of Oncology of Asturias (IUOPA), CIBERONC, Hospital Central de Asturias, Universidad de Oviedo, Oviedo, Spain.

Background: Succinate dehydrogenase subunit B (SDHB) immunohistochemistry was considered a valuable tool to identify patients with inherited paraganglioma/pheochromocytoma (PGL/PCC). However, previous studies jointly analyzed 2 related but clinically distinct entities, parasympathetic head and neck paragangliomas (HNPGLs) and sympathetic PCCs/PGLs. Additionally, a role for hypoxia inducible factor-1α (HIF-1α) as a biomarker for succinate dehydrogenase (SDHx)-mutated tumors has not been studied. Read More

View Article
December 2018

Waist circumference and abdominal volume index are the strongest anthropometric discriminators of metabolic syndrome in Spanish adolescents.

Eur J Clin Invest 2018 Dec 14:e13060. Epub 2018 Dec 14.

Department of Nursing, University of Granada, Av. Ilustración, 60, 18016, Granada, Spain.

Background: Waist circumference has been suggested as predictor for metabolic syndrome (MetS) in adolescents but it has not been compared with newly proposed anthropometric indexes. This study aimed to disclose the capacity of ten classic and novel anthropometric indexes to discriminate by the presence of MetS in this young population.

Materials And Methods: A cross-sectional study was performed on 981 adolescents (13. Read More

View Article
December 2018

Optimizing the Clinical Utility of Sirolimus-Based Immunosuppression for Kidney Transplantation.

Clin Transplant 2018 Dec 13:e13464. Epub 2018 Dec 13.

Clínica Universitaria Colombia, Fundacion Universitária de Ciencias de la Salud, Bogotá, Colombia.

While calcineurin inhibitors (CNIs) are effective for preventing acute rejection in kidney transplant recipients, long-term use may cause chronic kidney injury and is associated with increased risks of cardiovascular events, cancer, and infection-associated death. Immunosuppression strategies are needed to balance risks of acute and subclinical rejection with long-term benefits of improved kidney function. Sirolimus, an inhibitor of mammalian target of rapamycin, is used for immunosuppression in kidney transplantation. Read More

View Article
December 2018

Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida & CIBERONC, Lleida, Spain.

Background: Recent epidemiological studies suggest that past data where superficial spreading melanoma was by far the most common subtype of melanoma may not reflect current patterns of sun exposure or other risk factors more involved in other subtypes of melanoma as lentigo maligna (LM) or lentigo maligna melanoma (LMM).

Methods: In order to measure the current situation in our country, all cases of LM and LMM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007, were recorded.

Results: Although for the global period LM/LMM represented only 8. Read More

View Article
December 2018

Multiple imputation approach for interval-censored time to HIV RNA viral rebound within a mixed effects Cox model.

Biom J 2018 Dec 13. Epub 2018 Dec 13.

Departarment d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya/BARCELONATECH, Barcelona, Spain.

We present a method to fit a mixed effects Cox model with interval-censored data. Our proposal is based on a multiple imputation approach that uses the truncated Weibull distribution to replace the interval-censored data by imputed survival times and then uses established mixed effects Cox methods for right-censored data. Interval-censored data were encountered in a database corresponding to a recompilation of retrospective data from eight analytical treatment interruption (ATI) studies in 158 human immunodeficiency virus (HIV) positive combination antiretroviral treatment (cART) suppressed individuals. Read More

View Article
December 2018

Data-driven adult asthma phenotypes based on clinical characteristics are associated with asthma outcomes twenty years later.

Allergy 2018 Dec 13. Epub 2018 Dec 13.

Inserm, Univ. Grenoble Alpes, CNRS, IAB, Team of environmental epidemiology applied to reproduction and respiratory health, 38000, Grenoble, France.

Background: Research based on cluster analyses led to the identification of particular phenotypes confirming phenotypic heterogeneity of asthma. The long-term clinical course of asthma phenotypes defined by clustering analysis remains unknown, although it is a key aspect to underpin their clinical relevance. We aimed to estimate risk of poor asthma events between asthma clusters identified 20 years earlier. Read More

View Article
December 2018

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Grup d'Oncogènesi i Antitumorals, lnstitut d'Investigacions Biomèdiques Sant Pau (IIB-Sant Pau), Barcelona, Spain.

Background: Serpin Family E Member 1 (SerpinE1) overexpression associates with poor clinical outcome in head and neck squamous cell carcinoma (HNSCC) patients. This study analyzed the role of serpinE1 in HNSCC dissemination.

Methods: We studied the phenotypic characteristics and dissemination of HNSCC cells overexpressing serpinE1 using an orthotopic model and the association between serpinE1 overexpression and clinicopathological variables in patients included in The Cancer Genome Atlas database. Read More

View Article
December 2018

African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children.

Pediatr Pulmonol 2018 Dec 11. Epub 2018 Dec 11.

Institute of Collective Health, Federal University of Bahia, Salvador, Bahia, Brazil.

Background: Genetic variants underlying African ancestry have been suggested be implicated in the ethnic-racial inequalities reported for asthma and allergies.

Objectives: To investigate the association between individual African ancestry and asthma symptoms, atopic and non-atopic asthma, and atopy in children.

Methods: A cross-sectional study encompassing 1190 individuals was conducted. Read More

View Article
December 2018
1 Read

Identification of a de novo splicing variant in the Coffin-Siris gene, SMARCE1, in a patient with Angelman-like syndrome.

Mol Genet Genomic Med 2018 Dec 11. Epub 2018 Dec 11.

Genetics Laboratory, UDIAT-Centre Diagnòstic, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.

Background: Patients affected by Angelman syndrome (AS) present severe intellectual disability, lack of speech, ataxia, seizures, abnormal electroencephalography (EEG), and a characteristic behavioral phenotype. Around 10% of patients with a clinical diagnosis of AS (AS-like) do not have an identifiable molecular defect. Some of these patients harbor alternative genetic defects that present overlapping features with AS. Read More

View Article
December 2018

Methods of the ITC Four Country Smoking and Vaping Survey, Wave 1 (2016).

Addiction 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychology, University of Waterloo, Waterloo, Ontario, Canada.

Aim: To describe the methods of the 2016 International Tobacco Control (ITC) Four Country Smoking and Vaping (4CV) Survey, conducted in 2016 in Australia (AU), Canada (CA), England (EN), and the United States (US).

Methods: The respondents were cigarette smokers, former smokers (quit within the previous two years), and at-least-weekly vapers, aged 18 and older. Eligible cohort members from the ITC Four Country Survey (4C) were retained. Read More

View Article
December 2018

Prevalence of intestinal parasites and the absence of soil-transmitted helminths in Añatuya, Santiago del Estero, Argentina.

Parasit Vectors 2018 Dec 14;11(1):638. Epub 2018 Dec 14.

Fundación Mundo Sano, Paraguay, 1535, Buenos Aires, Argentina.

Background: Intestinal parasites (IP) have been reported in point studies from different provinces of Argentina. The presence of soil-transmitted helminths (STH) was detected in many of these studies, including varied prevalences of all five species of STH in the north were the climate is more appropriate for transmission. Nonetheless, Argentina lacks a comprehensive prevalence map of STH. Read More

View Article
December 2018

Impact  of an integral assistance model between primary care and cardiology on the management of patients with ischemic heart disease or atrial fibrillation.

J Comp Eff Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain.

Aim: To analyze the impact of implementing a program integrating cardiology and primary care in clinical practice.

Methods: In the integrated care model, every cardiologist was assigned to each primary care center.

Results & Conclusion: The implementation of the new care model was associated with a significant reduction of 31. Read More

View Article
December 2018

[What can be done to achieve therapeutic adherence to nutritional supplements?]

Carmen Urzola

Nutr Hosp 2018 Apr 3;35(Spec no2):44-51. Epub 2018 Apr 3.


Oral dietary supplements, are part of the medical treatment, the success of oral supplements depends on the Adherence of the patient to meet the prescribed therapeutic indications in the hospital and once the patient is discharged, if this was necessary. The World Health Organization (WHO) defines Treatment Adherence and Compliance as "the degree to which the behavior of a patient, in relation to taking medicine, following a diet or modifying the habits of life, corresponds whit the recommendations agreed on, whit the health personnel". The Therapeutic Adherence, is a complex process that is influenced by multiple factors, which are related to the patients, the professionals, the health system, the illness and whit the treatment, it is a problem of great importance for clinical practice and must be approached both from points, the preventive and interventive, once it is detected. Read More

View Article

Urinary Metal Levels in a Chilean Community 31 Years After the Dumping of Mine Tailings.

J Health Pollut 2016 Jun 16;6(10):19-27. Epub 2016 Jun 16.

Departamento de Salud Pública, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Between 1938 and 1975, the city of Chañaral, located in the north of Chile, received 200 megatons of unregulated mining waste, which created an artificial beach 10 kilometers long and covering an area larger than 4 km. In 1983, this deposit was classified as a serious case of marine pollution in the Pacific Ocean, according to the Organization for Economic Cooperation and Development. In 1989, dumping ceased due to a judicial order. Read More

View Article

Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model.

Cancer Immunol Immunother 2018 Dec 13. Epub 2018 Dec 13.

Center for Applied Medical Research (CIMA), Program of Immunology and Immunotherapy, University of Navarra, Pío XII 55, 31008, Pamplona, Spain.

Immune checkpoint inhibitors are currently tested in different combinations in patients with advanced hepatocellular carcinoma (HCC). Nivolumab, an anti-PD-1 agent, has gained approval in the second-line setting in the USA. Epigenetic drugs have immune-mediated antitumor effects that may improve the activity of immunotherapy agents. Read More

View Article
December 2018

Correction to: Morphological MRI-based features provide pretreatment survival prediction in glioblastoma.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Mathematical Oncology Laboratory (MôLAB), Department of Mathematics, Universidad de Castilla-La Mancha, 13071, Ciudad Real, Spain.

The original version of this article, published on 15 October 2018, unfortunately contained a mistake. The following correction has therefore been made in the original: The name of Mariano Amo-Salas and the affiliation of Ismael Herruzo were presented incorrectly. Read More

View Article
December 2018

Improving pharmacogenetic prediction of extrapyramidal symptoms induced by antipsychotics.

Transl Psychiatry 2018 Dec 13;8(1):276. Epub 2018 Dec 13.

Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.

In previous work we developed a pharmacogenetic predictor of antipsychotic (AP) induced extrapyramidal symptoms (EPS) based on four genes involved in mTOR regulation. The main objective is to improve this predictor by increasing its biological plausibility and replication. We re-sequence the four genes using next-generation sequencing. Read More

View Article
December 2018

Analysis of expression of the PD-1/PD-L1 immune checkpoint system and its prognostic impact in gastroenteropancreatic neuroendocrine tumors.

Sci Rep 2018 Dec 13;8(1):17812. Epub 2018 Dec 13.

Services of Endocrinology, Immunology and Molecular Biology Unit, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Instituto Princesa, 28006, Madrid, Spain.

The immune checkpoint based therapy targeting the programmed death-1 (PD-1) receptor and its PD-L1 ligand has recently been approved for the therapy of different malignant conditions, but not yet for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). In this context, we evaluated the expression of PD-1 and PD-L1 in GEP-NETs and its potential correlations with clinical outcomes. Expression of PD-1/PD-L1 was analyzed by immunohistochemistry in 116 GEP-NETs and 48 samples of peritumoral tissue. Read More

View Article
December 2018

[Updated report on STOPP-START criteria in Primary Care].

Semergen 2018 Dec 10. Epub 2018 Dec 10.

Unidad de Salud Pública, Gerencia del Área Sanitaria IV, SESPA, Oviedo, Asturias, España.

Introduction: The aim of this study is to determine the rate of potentially inappropriate prescriptions (PIP) in people older than 64 years of age in Avilés, Asturias, Spain.

Materials And Methods: A descriptive cross-sectional study was conducted in six Health Care Centres. A sample of 400 people was selected, obtained by a random sampling proportional to the population registered in each Health Centre. Read More

View Article
December 2018

3D microsurgical anatomy of the corticospinal tract and the lemniscus tract based on microdissection of fibres and demonstration through tractography.

Neurocirugia (Astur) 2018 Dec 10. Epub 2018 Dec 10.

Servicio de Neurocirugía, Hospital de San José, Fundación Universitaria de Ciencias de la Salud, Sociedad de Cirugía de Bogotá, Bogotá, D. C., Colombia. Electronic address:

View Article
December 2018