61,845 results match your criteria Salud i Ciencia Health i Science [Journal]


Trichoderma longibrachiatum-An unusual pathogen of fungal pericarditis.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology. Hospital Universitario 12 de Octubre. Madrid. Spain.

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http://dx.doi.org/10.1016/j.cmi.2019.02.006DOI Listing
February 2019

Forms of extracellular mitochondria and their impact in health.

Mitochondrion 2019 Feb 13. Epub 2019 Feb 13.

Universidad San Francisco de Quito, Colegio de Ciencias de la Salud - Hospital de los Valles, Escuela de Medicina, Quito 17-12-841, Ecuador; Universidad San Francisco de Quito, Instituto de Investigaciones en Biomedicina, Quito 17-12-841, Ecuador; Mito-Act Research Consortium, Quito, Ecuador; Sistemas Médicos - Universidad San Francisco de Quito, SIME-USFQ, Quito 17-12-841, Ecuador. Electronic address:

Mitochondria play an important role as an intracellular energy plant and signaling organelle. However, mitochondria also exist outside cells where they could mediate cell-to-cell communication, repair and serve as an activator of the immune response. Their effects depend on the mitochondrial state or the form in which it is present, either as a whole functional structure as fragments or only as mitochondrial DNA. Read More

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http://dx.doi.org/10.1016/j.mito.2019.02.002DOI Listing
February 2019

Interventions for the control of Aedes aegypti in Latin America and the Caribbean: Systematic Review and Meta-Analysis.

Trop Med Int Health 2019 Feb 16. Epub 2019 Feb 16.

Instituto de Efectividad Clínica y Sanitaria, Centro de Investigación de Epidemiología y Salud Pública, Argentina.

Objective: To determine the effectiveness and degree of implementation of interventions for the control of Aedes aegypti in Latin America and the Caribbean (LAC) as reported in scientific literature.

Methods: We searched MEDLINE, EMBASE, CENTRAL, SOCINDEX and LILACS, for experimental and observational studies, economic assessments and qualitative experiences carried out in LAC from 2000 to 2016. We assessed incidence and morbimortality of Aedes aegypti-related diseases and entomological indices: Breteau (containers), House, and Pupae per Person. Read More

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http://dx.doi.org/10.1111/tmi.13217DOI Listing
February 2019

Prevalence and Correlates of Injecting with Visitors from the United States Among People Who Inject Drugs in Tijuana, Mexico.

J Immigr Minor Health 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, MC-0725, La Jolla, CA, 92093-0725, USA.

Cross-border infectious disease transmission is a concern related to drug tourism from the U.S. to Mexico. Read More

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http://dx.doi.org/10.1007/s10903-019-00868-8DOI Listing
February 2019

Incidence of perineal pain and dyspareunia following spontaneous vaginal birth: a systematic review and meta-analysis.

Int Urogynecol J 2019 Feb 15. Epub 2019 Feb 15.

Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Introduction And Hypothesis: Perineal pain and dyspareunia are experienced by women undergoing a vaginal birth that can have short and longer term physical and psychological morbidities. This review aimed to determine the incidence of perineal pain and dyspareunia following spontaneous vaginal birth (SVB) with intact perineum, first and second-degree perineal trauma or episiotomy.

Methods: Searches of MEDLINE, EMBASE, CINAHL, AMED and MIDIRS (inception - December 2017) were undertaken with selection criteria of any study evaluating the effect of intact perineum, first- or second-degree perineal trauma on perineal pain or dyspareunia in women with SVB. Read More

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http://dx.doi.org/10.1007/s00192-019-03894-0DOI Listing
February 2019

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma.

Cell Mol Life Sci 2019 Feb 15. Epub 2019 Feb 15.

Group of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-Universitat Autònoma de Barcelona (UAB), Passeig Vall d'Hebron 119-129, Collserola Building. Lab 207, 08035, Barcelona, Spain.

Current therapies for most non-infectious diseases are directed at or affect functionality of the human translated genome, barely 2% of all genetic information. By contrast, the therapeutic potential of targeting the transcriptome, ~ 70% of the genome, remains largely unexplored. RNA therapeutics is an emerging field that widens the range of druggable targets and includes elements such as microRNA. Read More

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http://dx.doi.org/10.1007/s00018-019-03041-4DOI Listing
February 2019

Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Medical and Surgical Research Unit, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO removal while potentially reducing the risk of ventilator-induced lung injury.

Objective: To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.

Study Design: Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO). Read More

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http://dx.doi.org/10.1038/s41372-019-0338-5DOI Listing
February 2019

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.

Cell Death Differ 2019 Feb 15. Epub 2019 Feb 15.

Redox Homeostasis Group, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013, Sevilla, Spain.

In the presence of aggregation-prone proteins, the cytosol and endoplasmic reticulum (ER) undergo a dramatic shift in their respective redox status, with the cytosol becoming more oxidized and the ER more reducing. However, whether and how changes in the cellular redox status may affect protein aggregation is unknown. Here, we show that C. Read More

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http://dx.doi.org/10.1038/s41418-018-0270-9DOI Listing
February 2019

Improvements cardiometabolic risk factors in Latin American Amerindians (the Mapuche) with concurrent training.

Scand J Med Sci Sports 2019 Feb 15. Epub 2019 Feb 15.

Education department of La Unión city, Chile.

Our aim was to investigate the effects of 12-weeks of CT (i.e., high-intensity interval and resistance training) in Mapuche adults from Chile and in their peers of European descent. Read More

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http://dx.doi.org/10.1111/sms.13409DOI Listing
February 2019

Long-term Efficacy and Safety of Monotherapy Versus Combination Therapy in Systemic Sclerosis-associated Pulmonary Arterial Hypertension: A Retrospective Cohort Study from the Nationwide Spanish Scleroderma Registry (RESCLE).

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Autoimmune Diseases Unit. Department of Internal Medicine. Bellvitge University Hospital. L'Hospitalet de Llobregat, Barcelona, Spain; Department of Internal Medicine. Corporación Sanitaria Universitaria Parc Taulí. Sabadell, Barcelona, Spain; Unit of Autoimmune Diseases, Department of Internal Medicine. Hospital Universitario Vall d'Hebron. Barcelona, Spain; Unit of Systemic Autoimmune Diseases and Thrombosis. Department of Internal Medicine. Complejo Hospitalario Universitario de Vigo. Vigo, Pontevedra, Spain; Department of Internal Medicine. Hospital Universitario Virgen de las Nieves. Granada, Spain; Department of Internal Medicine. Hospital Universitario y Politécnico La Fe. Valencia, Spain; Department of Internal Medicine. Hospital Universitario Mútua Terrassa. Terrassa, Barcelona, Spain; Unit of Autoimmune Diseases, Department of Internal Medicine. Hospital Clínico Universitario Lozano Blesa. Zaragoza, Spain; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology. Hospital Universitario Clinic. Barcelona, Spain; Department of Internal Medicine. Hospital Universitario Central de Asturias. Oviedo, Asturias, Spain; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine. Hospital Campus de la Salud, Complejo Universitario de Granada. Granada, Spain; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine. Hospital de Cabueñes. Gijón, Asturias, Spain; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Spain; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine. Consorci Hospitalari de Vic. Vic, Barcelona, Spain; Department of Internal Medicine. Hospital Universitario Rey Juan Carlos. Móstoles, Madrid, Spain; Faculty of Medicine and Health Sciences. Universitat Internacional de Catalunya,Barcelona,Spain. Address correspondence to: Melani Pestaña-Fernández MD; Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat Barcelona (Spain). Email:

Objective: Monotherapy is an option as first line therapy for pulmonary arterial hypertension (PAH). However, combination therapy is a beneficial alternative. Our objective was to evaluate efficacy of monotherapy vs. Read More

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http://dx.doi.org/10.3899/jrheum.180595DOI Listing
February 2019
3.187 Impact Factor

Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Medical Oncology, University of Colorado Anschutz Medical Campus.

Purpose: IDO1 induces immune suppression in T cells through L-tryptophan (Trp) depletion and kyneurinine (Kyn) accumulation in the local tumor microenvironment, suppressing effector T-cells and hyperactivating Tregs. Navoximod is an investigational small molecule inhibitor of IDO1. This Phase I study evaluated safety, tolerability, PK and PD of navoximod in combination with atezolizumab, a PD-L1 inhibitor, in patients with advanced cancer. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2740DOI Listing
February 2019

[Food quality in the elderly population in Santiago of Chile].

Rev Esp Geriatr Gerontol 2019 Feb 12. Epub 2019 Feb 12.

Facultad de Ciencias para el Cuidado de la Salud, Universidad San Sebastián, Santiago, Chile. Electronic address:

Introduction: With the increase in the elderly population of Chile, it is very important to evaluate the quality of food of this age group using simple and quick tools.

Objective: To compare the food quality of the elderly, according to gender and age.

Material And Methods: A cross sectional study was conducted on 458 elderly subjects ≥60 years-old of Santiago de Chile. Read More

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http://dx.doi.org/10.1016/j.regg.2019.01.002DOI Listing
February 2019

[Nutritional composition of vending foods of public university and hospital buildings in Asturias].

Aten Primaria 2019 Feb 12. Epub 2019 Feb 12.

Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Campus del Cristo, Oviedo, España.

Objective: To evaluate the nutritional composition of food vending machines (VM) located in university public buildings and hospitals in Asturias.

Design: Descriptive cross-sectional study.

Location: The analysis was made of the contents of VMs located in public buildings, hospitals, and university teaching centres in the Principality of Asturias. Read More

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http://dx.doi.org/10.1016/j.aprim.2018.04.010DOI Listing
February 2019

[Profiles of loneliness and social isolation in urban population].

Aten Primaria 2019 Feb 12. Epub 2019 Feb 12.

CAPSBE, Barcelona, España.

Objective: To assess the prevalence of loneliness and social isolation in a population over 65 cared by a urban primary health team and to identify its main characteristics.

Design: Cross-sectional descriptive study by a telephone survey.

Setting: Basic health area of Barcelona. Read More

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http://dx.doi.org/10.1016/j.aprim.2018.09.012DOI Listing
February 2019

Bacteremia caused by Herbaspirillum huttiense in a newborn.

Enferm Infecc Microbiol Clin 2019 Feb 12. Epub 2019 Feb 12.

Servicio de Microbiología y Parasitología Clínica, Hospital Universitario La Paz, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.eimc.2018.12.011DOI Listing
February 2019

Adherence and Concordance of Influenza and Pertussis Vaccination Coverage in Pregnant Women in Spain.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Unidad Mixta de Investigación para el Análisis de las Desigualdades en Salud y la Mortalidad FISABIO-UA, Departament of Community Health, Preventive Medicine and Public Health, and Science's History, University of Alicante, Carretera de San Vicente del Raspeig s/n, 03690 Alicante, Spain.

: Pregnant women should receive two vaccines during pregnancy due to maternal-foetal complications and risks as well as the influenza and pertussis vaccinations. The goal was to evaluate vaccination coverage against influenza and pertussis in pregnant women, following midwife professional advice during the pregnancy follow-up; : Prospective cohort study of 1017 pregnancies during the vaccination campaign in 2015⁻2016. To estimate the degree of consistency between the coverage declared by mothers and that registered in the Nominal Vaccination Registry (NVR), we used the Cohen's kappa index (k); : 95. Read More

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http://dx.doi.org/10.3390/ijerph16040543DOI Listing
February 2019

Decreased ghrelin levels: the cause of obesity and weight regain?

Expert Rev Endocrinol Metab 2012 Mar;7(2):127-129

b Department of Medicine, Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (CHUS), CIBER de Fisiopatologia Obesidad y Nutricion (CB06/03), Instituto Salud Carlos III, Santiago de Compostela, Spain.

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http://dx.doi.org/10.1586/eem.11.94DOI Listing

Early and premature menopause in women with diabetes mellitus Type 2.

Expert Rev Endocrinol Metab 2014 Jul 23;9(4):297-299. Epub 2014 May 23.

b Grupo de Investigación Salud de la Mujer, Asesor internacional, Orquédeas 1068, Dpto 302, Providencia 7510258, Santiago de Chile, Chile.

Those women who have early menopause have major cardiovascular and metabolic risk. The menopause below 40 years of age has been associated to increase in the risk of early beginning of osteoporosis, cardiovascular disease and diabetes mellitus, disorders characterized by hyperglycemia and glucose intolerance due to deficiency of insulin, decrease of the effectiveness of its action or both. The menopausal hormone therapy is the principal therapeutic tool, with the aim to contribute estrogens to suppress the clinical symptomatology and to make a favorably impact on the estrogen-dependent tissues. Read More

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http://dx.doi.org/10.1586/17446651.2014.922863DOI Listing

Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water.

Environ Toxicol Pharmacol 2019 Feb 7;67:79-86. Epub 2019 Feb 7.

Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Rio-verde, San Luis Potosí, Mexico. Electronic address:

The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.004DOI Listing
February 2019

Rapid assessment of enhanced safety surveillance for influenza vaccine.

Public Health 2019 Feb 12;168:137-141. Epub 2019 Feb 12.

Dirección General de Salud Pública, Conselleria de Sanidad Universal y Salud Pública, Valencia, Spain.

Objectives: The enhanced safety surveillance for seasonal influenza vaccines established by the European Medicines Agency is required each season. Therefore, a registry capable of rapidly detecting and evaluating potential new safety concerns is needed. The aim of the study is to demonstrate the effectiveness of the vaccine information system of the Valencia region to make a rapid assessment of the influenza vaccine safety and describe the safety of the two vaccine types used in the 2017/2018 season. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.013DOI Listing
February 2019

Activity of ceftolozane-tazobactam against Pseudomonas aeruginosa and Enterobacterales isolates recovered in Intensive Care Units in Spain: The SUPERIOR multicentre study.

Int J Antimicrob Agents 2019 Feb 12. Epub 2019 Feb 12.

Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain. Electronic address:

Patients in intensive care units (ICUs) present a high risk of developing an infection caused by multi-drug resistant (MDR) bacteria. Consequently, new antimicrobials and combinations are needed. We evaluated the activity of ceftolozane-tazobactam against Enterobacterales (n=400) and Pseudomonas aeruginosa (n=80) isolates collected from patients in Spanish intensive care units (ICUs) with complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI). Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.02.004DOI Listing
February 2019

FLEAS ASSOCIATED WITH SIGMODONTINE RODENTS AND MARSUPIALS FROM THE PARANAENSE FOREST IN NORTHEASTERN ARGENTINA.

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Centro de Estudios Parasitológicos y de Vectores (CEPAVE) (CONICET CCT La Plata-UNLP), Boulevard 120 s/n e/60 y 64, 1900, La Plata, Argentina. Electronic address:

Fleas from the Paranaense Forest in northeastern Argentina are studied. Herein we provided a list of specimens identified, which includes host species and geographical distribution for each taxa, as well as some comments on the morphology, distribution and epidemiological importance when available. The following eight species and subspecies of fleas belonging to four families were identified: Ctenocephalides felis felis (Pulicidae), Craneopsylla minerva minerva (Stephanocircidae), Polygenis (Polygenis) platensis, Polygenis (Polygenis) roberti beebei, Polygenis (Neopolygenis) pradoi, Polygenis (Neopolygenis) pygaerus (Rhopalopsyllidae), Adoratopsylla (Adoratopsylla) antiquorum antiquorum, and Adoratopsylla (Tritopsylla) intermedia intermedia (Ctenophthalmidae). Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.011DOI Listing
February 2019

Methodological aspects of Universal immuno-PCR on standard tubes.

Anal Biochem 2019 Feb 12. Epub 2019 Feb 12.

Instituto de Salud y Ambiente Del Litoral ISAL, CONICET-UNL, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional Del Litoral, Ciudad Universitaria, Ruta Nacional N°168, km 472, CPA S3000ZAA, Santa Fe, Argentina. Electronic address:

One of the most used formats in inmuno-polymerase chain reaction (IPCR) is known as "Universal" IPCR (signal-generating complexes is based on conjugates of biotinylated DNA, biotinylated IgG and avidin). In the present study, we evaluated the utility of using mono- and bi-biotinylated DNA probes, pre-self-assembled DNA-neutravidin complex, blocking step and glutaraldehyde pretreatment of standard PCR tubes to improve the analytical performance of the hTSH-IPCR assay. The use of pre-self-assembled mono-biotinylated DNA-neutravidin complex enhances both the sensitivity and the reproducibility of the hTSH-IPCR assay, even without blocking step: hTSH-IPCR assay showed an improved limit of detection (LOD: 0. Read More

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http://dx.doi.org/10.1016/j.ab.2019.02.007DOI Listing
February 2019

Pharmacokinetics of meloxicam after oral administration of a granule formulation to healthy horses.

J Vet Intern Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Animal Medicine and Surgery, University of Cordoba, Cordoba, Spain.

Background: Nonsteroidal anti-inflammatory drugs are administered in horses for several systemic diseases. Selective cyclooxygenase-2 inhibitors are preferred because of lower risk of adverse effects. Several meloxicam formulations have been tested in horses, but a recently marketed granule oral formulation has not been studied. Read More

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http://dx.doi.org/10.1111/jvim.15433DOI Listing
February 2019

Latino Health Perceptions in Rural Montana: Engaging Promotores de Salud Using Photovoice Through Facebook.

Fam Community Health 2019 Apr/Jun;42(2):150-160

Departments of Health and Human Development (Miss Nitzinger and Eudave and Dr Held) and Letters and Science (Dr Kevane), Montana State University, Bozeman.

The primary purposes of this study were to use photovoice with Facebook to explore health perceptions and health needs among promotores living in rural Montana and to build community among geographically dispersed promotores. Seven promotores participated in a photovoice project where they uploaded photographs and shared comments in a private Facebook group. Emergent themes based on the promotores' health perceptions, discussions, and interviews were transcribed and coded. Read More

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http://dx.doi.org/10.1097/FCH.0000000000000213DOI Listing
February 2019

Emotional Experiences of Mothers Living With HIV and the Quest for Emotional Recovery: A Qualitative Study in Lima, Peru.

J Assoc Nurses AIDS Care 2019 Feb 13. Epub 2019 Feb 13.

Carmen Contreras, BA, is Director of Intervention Projects, Socios En Salud, Partners In Health, Lima, Peru. Nancy Rumaldo, BA, is a Project Coordinator, Socios En Salud, Partners In Health, Lima, Peru. Michael Masao Lindeborg, BA, is an MD candidate, Harvard Medical School, Boston, Massachusetts, USA. Milagros Mendoza, BA, is a Project Manager, Socios En Salud, Partners In Health, Lima, Peru. David Roy Chen, BA, is an MD candidate, University of Washington School of Medicine, Seattle, Washington, USA. Olga Saldaña, RN, is a Field Coordinator, Socios En Salud, Partners In Health, Lima, Peru. Milagros Wong, RN, is a Project Manager, Socios En Salud, Partners In Health, Lima, Peru. Maribel Muñoz, RN, is a Project Manager, Socios En Salud Partners In Health, Lima, Peru. Elizabeth Schrier, BA, is a Research Assistant, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Leonid Lecca, MD, MPH, is a Lecturer on Global Health and Social Medicine, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA, and Executive Director of Socios En Salud, Partners In Health, Lima, Peru. Arachu Castro, PhD, MPH, is the Samuel Z. Stone Endowed Chair of Public Health in Latin America, Department of Global Community Health and Behavioral Sciences, and Director of the Collaborative Group for Health Equity in Latin America (CHELA), Tulane School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA. Sonya Sunhi Shin, MD, MPH, is an Associate Physician of Infectious Disease, Division of Global Health Equity at Brigham and Women's Hospital, Boston, Massachusetts, USA. Adrianne Katrina Nelson, MPH, Msc, is a Research Manager, Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Little evidence exists about the emotional experiences of mothers with HIV, and a better understanding is essential to support their emotional health and treatment adherence. We describe the emotional experiences of eight mothers who initiated antiretroviral therapy during pregnancy or within a few years of childbirth in Lima, Peru. An interpretive phenomenological approach was used, and the following themes emerged: (a) emotions involved in diagnosis and disclosure, (b) the meaning of motherhood with HIV, (c) the mothers' roles in seeking and maintaining relationships with partners and families, and (d) mechanisms for resilience and emotional recovery. Read More

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http://dx.doi.org/10.1097/JNC.0000000000000051DOI Listing
February 2019
1.228 Impact Factor

Common Polygenic Variations for Psychiatric Disorders and Cognition in Relation to Brain Morphology in the General Pediatric Population.

J Am Acad Child Adolesc Psychiatry 2019 Jan 9. Epub 2019 Jan 9.

Erasmus University Medical Center, Rotterdam, the Netherlands.

Objective: To examine the relationship between polygenic scores (PGS) for five major psychiatric disorders and two cognitive traits with brain MRI morphological measurements in a large population-based sample of children. Additionally, we tested whether differences in brain morphology mediated associations between PGS for psychiatric disorders and related behavioral phenotypes.

Method: The participants included 1,139 children from the Generation R Study assessed at 10 years-of-age with genotype and neuroimaging data available. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.09.443DOI Listing
January 2019

Evaluation of endothelial function and diastolic function in patients with primary hyperparathyroidism before and after parathyroidectomy.

Cir Cir 2019 ;87(2):196-204

Unidad de Investigación en Endocrinología Experimental. Hospital de Especialidades Centro Médico Nacional Siglo XXI. Ciudad de México, México.

Introduction: Primary hyperparathyroidism (PHPT) is the leading cause of outpatient hypercalcemia associated with increased cardiovascular risk. The flow-mediated vasodilation (FMV) has been proposed as a non-invasive method for assessing endothelial function.

Objective: To compare the endothelial dysfunction measured by FMV and diastolic dysfunction in patients with PHPT before and after parathyroidectomy. Read More

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http://dx.doi.org/10.24875/CIRU.18000520DOI Listing
January 2019

Starch as a risk factor for increased trans surgical bleeding in total hip arthroplasty.

Cir Cir 2019 ;87(2):164-169

División de Investigación en Salud, Unidad Médica de Alta Especialidad Dr. Victorio de la Fuente Narváez, IMSS. México.

Objective: Establish whether the use of starch in hip arthroplasty is a risk factor for excessive surgical bleeding and requirement of red blood cell transfusion.

Method: Analytical observational retrospective study in 240 patients who underwent primary total hip arthroplasty from January 2015 to January 2016. Two groups were formed: starch (94 patients) and non-starch (146 patients). Read More

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http://dx.doi.org/10.24875/CIRU.18000397DOI Listing
January 2019

Citroniella saccharovorans gen. nov. sp. nov., a member of the family Peptoniphilaceae isolated from a human fecal sample from a coastal traditional community member.

Int J Syst Evol Microbiol 2019 Feb 15. Epub 2019 Feb 15.

1​Department of Microbiology and Plant Biology, University of Oklahoma, USA.

A novel Gram-stain-positive, non-motile, non-spore-forming coccus-shaped obligately anaerobic bacterium was recovered from a fecal sample obtained from an individual from a traditional community located on the southern coast of Peru. The results of analysis based on 16S rRNA gene sequencing indicated the novel bacterium to be phylogenetically distinct from other genera of members of the Peptoniphilaceae family, sharing a loose affinity with the genera Ezakiella, Finegoldia, Gallicola and Parvimonas. The major cellular fatty acids of the novel isolate were determined to be C16:0, C17:1ω8c, and C18:1ω9c. Read More

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http://dx.doi.org/10.1099/ijsem.0.003287DOI Listing
February 2019

A walk through tau therapeutic strategies.

Acta Neuropathol Commun 2019 Feb 15;7(1):22. Epub 2019 Feb 15.

AXON Neuroscience R&D Services SE, Dvorakovo nabrezie 10, 811 02, Bratislava, Slovakia.

Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease and related human tauopathies. There is a growing body of evidence indicating that pathological tau species can travel from cell to cell and spread the pathology through the brain. Throughout the last decade, physiological and pathological tau have become attractive targets for AD therapies. Read More

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-019-0664-zDOI Listing
February 2019
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Epidemiological and clinical characteristics and the approach to infant chickenpox in primary care.

Eur J Pediatr 2019 Feb 14. Epub 2019 Feb 14.

Primary health care Miralbueno, Servicio Aragonés de Salud, Zaragoza, Spain.

Chickenpox is not common in the first year of life (infant varicella) and there is a lack of data on its presentation, especially in primary care. A year-long observational study (July 2015-2016) carried out by a research network of primary care pediatricians throughout Spain.Two hundred and sixty-four pediatricians gathered data from 358 cases of clinically diagnosed chickenpox in infants. Read More

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http://dx.doi.org/10.1007/s00431-019-03332-9DOI Listing
February 2019

Estimating age-dependent survival when juveniles resemble females: Invasive ring-necked parakeets as an example.

Ecol Evol 2019 Jan 5;9(2):891-898. Epub 2019 Feb 5.

Animal Demography and Ecology Group IMEDEA, CSIC-UIB Esporles Spain.

Many species only show sexual dimorphism at the age of maturity, such that juveniles typically resemble females. Under these circumstances, estimating accurate age-specific demographic parameters is challenging. Here, we propose a multievent model parameterization able to estimate age-dependent survival using capture-recapture data with uncertainty in age and sex assignment of individuals. Read More

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http://dx.doi.org/10.1002/ece3.4366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362439PMC
January 2019

Neuregulin 4 Is a Novel Marker of Beige Adipocyte Precursor Cells in Human Adipose Tissue.

Front Physiol 2019 31;10:39. Epub 2019 Jan 31.

Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona, Girona, Spain.

Nrg4 expression has been linked to brown adipose tissue activity and browning of white adipocytes in mice. Here, we aimed to investigate whether these observations could be translated to humans by investigating mRNA and markers of brown/beige adipocytes in human visceral (VAT) and subcutaneous adipose tissue (SAT). We also studied the possible association of with insulin action. Read More

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http://dx.doi.org/10.3389/fphys.2019.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365457PMC
January 2019

Juvenile hormone controls ovarian development in female Anopheles albimanus mosquitoes.

Sci Rep 2019 Feb 14;9(1):2127. Epub 2019 Feb 14.

Department of Biological Sciences and Biomolecular Science Institute, Florida International University, Miami, FL, USA.

Anophelinae mosquitoes are vectors of human malaria, a disease that infects hundreds of millions of people and causes almost 600,000 fatalities annually. Despite their medical importance, laboratory studies on key aspects of Anophelinae reproductive biology have been limited, and in particular, relatively little is known about the role of juvenile hormone (JH) in the control of female reproduction. The study presented here attempts to fill a gap of knowledge in our understanding of the JH control of ovarian development in female Anophelinae mosquitoes, using Anopheles albimanus as a model. Read More

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http://dx.doi.org/10.1038/s41598-019-38631-6DOI Listing
February 2019

Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course.

Eur Respir J 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Rationale: We aimed to identify differentially methylated regions (DMRs) in cord blood DNA associated with childhood lung function, asthma and chronic obstructive pulmonary disease (COPD) across the life course.

Methods: We meta-analyzed epigenome-wide data of 1688 children from five cohorts to identify cord blood DMRs and their annotated genes, in relation to Forced Expiratory Volume in 1 s (FEV1), FEV1/Forced Vital Capacity (FVC), and Forced Expiratory Flow at 75% of FVC (FEF75) at ages 7-13 years. Identified DMRs were explored for associations with childhood asthma, adult lung function and COPD, gene expression and involvement in biological processes. Read More

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http://dx.doi.org/10.1183/13993003.01795-2018DOI Listing
February 2019

Effects of a standardized emergency department protocol on after-hours use of venous duplex ultrasound.

J Vasc Surg Venous Lymphat Disord 2019 Feb 11. Epub 2019 Feb 11.

Raymond G. Murphy VA Medical Center, Albuquerque, NM.

Objective: Vascular laboratory (VL) venous duplex ultrasound is the "gold standard" for diagnosis of lower extremity deep venous thrombosis (DVT), which is linked to many morbid conditions. Decreasing night and weekend use of VL services in the emergency department (ED) represents a potentially viable means of reducing costs as skilled personnel must remain on call and receive a wage premium when activated. We investigated the effects of workflow changes that required ED providers to use a computerized decision-making tool, integrated into the electronic medical record, to calculate a Wells score for each patient considered for an after-hours venous duplex ultrasound study for suspected DVT. Read More

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http://dx.doi.org/10.1016/j.jvsv.2018.11.010DOI Listing
February 2019

[Quality of life of parents of school age children with a birth weight less than 1500 grams].

An Pediatr (Barc) 2019 Feb 11. Epub 2019 Feb 11.

Facultad de Psicología, Instituto de Neurociencias del Principado de Asturias (INEUROPA), Universidad de Oviedo, Oviedo, España.

Introduction: The birth of a preterm child has a high family emotional cost. The aim of this study is to assess the quality of life of parents of children aged 5-7 years born prematurely (<1500g).

Participants And Methods: This is a cross-sectional study of a sample of parents of preterm infants admitted to a third level hospital in Spain between 2009 and 2011. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.10.013DOI Listing
February 2019

Lung function trajectories in health and disease.

Lancet Respir Med 2019 Feb 11. Epub 2019 Feb 11.

August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Barcelona, Spain; Centro de Investigación Biomédica en Red, Enfermedades Respiratorias, Instituto de Salud Carlos III (CIBER), Madrid, Spain.

The normal lung function trajectory from birth to death has three phases: a growth phase (from birth to early adulthood), a plateau phase (that lasts for a few years), and a decline phase resulting from physiological lung ageing. Numerous genetic and environmental factors can alter one or more of these phases. Evidence shows that several lung function trajectories exist throughout the life course and, importantly, that some of them are associated with substantial implications for health and disease. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30529-0DOI Listing
February 2019

[Pemphigoid and dementia].

Rev Esp Geriatr Gerontol 2019 Feb 11. Epub 2019 Feb 11.

Biogerontología, Departamento de Anatomía y Biología Celular, Universidad de Cantabria, Santander, Cantabria, España.

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http://dx.doi.org/10.1016/j.regg.2018.09.014DOI Listing
February 2019

Mixed infection of four diarrhoeagenic Escherichia coli pathotypes in a case of travellers' diarrhoea: Caracterisation of the isolates by whole-genome sequencing.

Enferm Infecc Microbiol Clin 2019 Feb 11. Epub 2019 Feb 11.

Laboratorio de Referencia e Investigación en Infecciones Bacterianas Transmitidas por Agua y Alimentos, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.eimc.2019.01.003DOI Listing
February 2019

[Clinical validation of 2 morbidity groups in the primary care setting].

Aten Primaria 2019 Feb 11. Epub 2019 Feb 11.

Coordinador general de las tecnologías de la información y comunicación, Departamento de Salud de la Generalidad de Cataluña, Barcelona, España.

Introduction: Adjusted Morbidity Groups (GMAs) and the Clinical Risk Groups (CRGs) are population morbidity based stratification tools which classify patients into mutually exclusive categories.

Objetive: To compare the stratification provided by the GMAs, CRGs and that carried out by the evaluators according to the levels of complexity.

Design: Random sample stratified by morbidity risk. Read More

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http://dx.doi.org/10.1016/j.aprim.2018.09.016DOI Listing
February 2019

Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey.

Respir Res 2019 Feb 14;20(1):33. Epub 2019 Feb 14.

Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

Background: Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investigated in longitudinal studies. Our aim is to investigate the associations of exposure to SHS in adults with respiratory symptoms, respiratory conditions and lung function over 20 years.

Methods: We used information from 3011 adults from 26 centres in 12 countries who participated in the European Community Respiratory Health Surveys I-III and were never or former smokers at all three surveys. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0996-zDOI Listing
February 2019
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Responsiveness and minimal clinically important difference of the Minnesota living with heart failure questionnaire.

Health Qual Life Outcomes 2019 Feb 14;17(1):36. Epub 2019 Feb 14.

Research Unit, Basurto University Hospital, Jado 4th floor, Avda Montevideo 18, 48013, Bilbao, Vizcaya, Spain.

Background: The Minnesota Living with Heart Failure Questionnaire (MLHFQ) is one of the most widely used health-related quality of life questionnaires for patients with heart failure (HF). The objective of the present study was to explore the responsiveness of the MLHFQ by estimating the minimal detectable change (MDC) and the minimal clinically important difference (MCID) in Spain.

Methods: Patients hospitalized for HF in the participating hospitals completed the MLHFQ at baseline and 6 months, plus anchor questions at 6 months. Read More

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http://dx.doi.org/10.1186/s12955-019-1104-2DOI Listing
February 2019

Sibship, physical activity, and sedentary behavior: a longitudinal, observational study among Mexican-heritage sibling dyads.

BMC Public Health 2019 Feb 14;19(1):191. Epub 2019 Feb 14.

Robbins College of Health and Human Sciences, Baylor University, One Bear Place #97343, Waco, TX, 76798-7343, USA.

Background: Shared genetic and environmental factors suggest that family relationships are important predictors of obesity-related behaviors, yet little is known about how siblings influence physical activity and sedentary behaviors. This study examined physical activity and sedentary behavior between sibling dyads across summer and fall time points and determined if birth order and gender modify the relationship between sibling behaviors.

Methods: Mexican-heritage families residing in colonias along the United States-Mexico border were recruited using promotoras de salud to participate in summer and school year surveys. Read More

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http://dx.doi.org/10.1186/s12889-019-6521-yDOI Listing
February 2019

Histology Strategies for Medical Implants and Interventional Device Studies.

Toxicol Pathol 2019 Feb 14:192623319827288. Epub 2019 Feb 14.

3 Charles River Laboratories, Frederick, Maryland, USA.

Histology of medical devices poses a variety of unique challenges. Comprehensive histologic assessment of medical devices often requires spatial context and high-quality retention of the device-tissue interface. However, the composition of many medical devices is often not amenable to traditional paraffin embedding and thus alternative specialized methodologies such as hard resin embedding must be used. Read More

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http://dx.doi.org/10.1177/0192623319827288DOI Listing
February 2019

Impact of dietary lipoic acid supplementation on liver mitochondrial bioenergetics and oxidative status on normally fed Wistar rats.

Int J Food Sci Nutr 2019 Feb 15:1-11. Epub 2019 Feb 15.

c Department of Nutrition, Food Science and Physiology , University of Navarra , Pamplona , Spain.

The aim of this study was to examine the effects of α-lipoic acid (α-LA) on liver mitochondrial bioenergetics and oxidative status for 8 weeks in normal-healthy animals. A pair-fed group was included to differentiate between α-LA direct effects and those changes due to reduced food intake. α-LA decreased body weight gain, liver weight and insulin levels with no differences compared to its pair-fed group. Read More

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http://dx.doi.org/10.1080/09637486.2019.1572716DOI Listing
February 2019

Long-term outcome and psychiatric comorbidity of adolescent-onset anorexia nervosa.

Clin Child Psychol Psychiatry 2019 Feb 15:1359104519827629. Epub 2019 Feb 15.

1 Department of Child and Adolescent Psychiatry and Psychology, 2017SGR881, Institute of Neurosciences, Hospital Clinic de Barcelona, Spain.

Objective:: To assess the outcome of adolescents with anorexia nervosa (AN) about 20 years after first treatment.

Methods:: Sixty-two women diagnosed with AN during adolescence were invited to participate. Of these 62 patients, 38 agreed to participate and were assessed with a battery of questionnaires and interviews. Read More

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http://dx.doi.org/10.1177/1359104519827629DOI Listing
February 2019
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Common Polymorphisms Linked to Obesity and Cardiovascular Disease in Europeans and Asians are Associated with Type 2 Diabetes in Mexican Mestizos.

Medicina (Kaunas) 2019 Feb 5;55(2). Epub 2019 Feb 5.

Laboratorio de Medicina Genómica, Hospital Regional Lic. Adolfo López Mateos ISSSTE, Mexico City 01030, Mexico.

Type 2 diabetes (T2D) is a major problem of public health in Mexico. We investigated the influence of five polymorphisms, previously associated with obesity and cardiovascular disease in Europeans and Asians, on T2D in Mexican Mestizos. A total of 1358 subjects from 30 to 85 years old were genotyped for five loci: rs501120; rs1333049; rs2259816; rs9939609; and rs7799039. Read More

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http://dx.doi.org/10.3390/medicina55020040DOI Listing
February 2019