63,206 results match your criteria Salud i Ciencia Health i Science [Journal]


QSAR modelling for predicting the toxic effects of traditional and derived biomass solvents on a Danio rerio biomodel.

Chemosphere 2019 Apr 10;227:480-488. Epub 2019 Apr 10.

Universidad San Jorge, Campus Universitario, Autov A23 Km 299, 50830, Villanueva de Gállego, Zaragoza, Spain. Electronic address:

The increasing interest in the development of ecofriendly solvents has led to the synthesis of benign alternative chemicals with minimized environmental impacts. These kinds of chemicals are known as Green solvents. In this work, we selected three families of solvents (furfural, lactate and levulinate families) derived from biomass that are structurally related. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.054DOI Listing

Spotlight on epigenetic reprogramming in cardiac regeneration.

Semin Cell Dev Biol 2019 Apr 16. Epub 2019 Apr 16.

Heart Failure and Cardiac Regeneration (ICREC) Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Carretera Canyet, s/n, Camí de les Escoles, s/n, 08916 Badalona, Spain; CIBERCV, Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain; Cardiology Service, HUGTiP, Carretera Canyet, s/n, 08916 Badalona, Spain; Department of Medicine, Barcelona Autonomous University (UAB), Carretera Canyet, s/n, Camí de les Escoles, s/n, 08916 Badalona, Spain.

Heart failure of ischemic origin is caused by the presence of a large scar resulting from an acute myocardial infarction. Acute myocardial infarction generally occurs when blood supply to the heart is blocked. Regenerative strategies that limit infarct injury would be able to prevent adverse post-ischemic remodelling and maintain the structural support necessary for effective cardiomyocyte contraction. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.009DOI Listing

Comparison of Risk of Osteoporotic Fracture in Denosumab vs Alendronate Treatment Within 3 Years of Initiation.

JAMA Netw Open 2019 Apr 5;2(4):e192416. Epub 2019 Apr 5.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Importance: Head-to-head randomized clinical trials showed greater efficacy of denosumab vs alendronate in improving bone mineral density. Although there is an association of changes in bone mineral density with reductions in fracture risk, the magnitude of the association is not well established.

Objective: To compare the risk of hip and any fracture in patients treated with denosumab and alendronate in routine practice settings. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2416DOI Listing
April 2019
1 Read

GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.

Acta Physiol (Oxf) 2019 Apr 19:e13283. Epub 2019 Apr 19.

University of Navarra, Department of Nutrition, Food Science and Physiology, Pamplona, Spain.

Aim: The facilitative glucose transporter GLUT12 was isolated from the breast cancer cell line MCF-7 by its homology with GLUT4. GLUT12 is expressed in insulin sensitive tissues such as adipose tissue. The aim of this work was to investigate GLUT12 expression and hormonal regulation in 3T3-L1 adipocytes and in adipose tissue of lean and diet-induced obese mice. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13283
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http://dx.doi.org/10.1111/apha.13283DOI Listing
April 2019
1 Read

Identification of Off-Patent Compounds That Present Antifungal Activity Against the Emerging Fungal Pathogen .

Front Cell Infect Microbiol 2019 2;9:83. Epub 2019 Apr 2.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.

is an emerging fungal pathogen of great concern among the scientific community because it is causing an increasing number of hospital outbreaks of difficult management worldwide. In addition, isolates from this species frequently present reduced susceptibility to azole and echinocandin drugs. For this reason, it is necessary to develop new antifungal strategies to better control the disease caused by this yeast. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454888PMC

Recent advances in managing/understanding the metabolic syndrome.

F1000Res 2019 3;8. Epub 2019 Apr 3.

Unidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14008, Mexico.

The metabolic syndrome (MetS) concept gathers in a single entity a set of metabolic abnormalities that have in common a close relationship with ectopic deposit of lipids, insulin resistance, and chronic low-grade inflammation. It is a valuable teaching tool to help health professionals to understand and integrate the consequences of lipotoxicity and the adverse metabolic consequences of insulin resistance. Also, it is useful to identify subjects with a high risk for having incident type 2 diabetes. Read More

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https://f1000research.com/articles/8-370/v1
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http://dx.doi.org/10.12688/f1000research.17122.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449786PMC
April 2019
1 Read

Nephroprotective Effect of Embryonic Stem Cells Reducing Lipid Peroxidation in Kidney Injury Induced by Cisplatin.

Oxid Med Cell Longev 2019 14;2019:5420624. Epub 2019 Mar 14.

Escuela Militar de Medicina, Centro Militar de Ciencias de la Salud, Secretaria de la Defensa Nacional, Ciudad de México 11200, Mexico.

Introduction: The acute kidney injury (AKI) is characterized by a sudden glomerular filtration reduction. Renal or intrinsic causes of AKI include nephrotoxicity induced by exogenous agents like cisplatin, which causes oxidative stress altering the biochemical process and leading to apoptosis. Therefore, this research is aimed at analyzing the embryonic stem cells (ESC) nephroprotective effect in AKI induced by cisplatin, employing genetic, phenotypic, and microspectroscopic techniques. Read More

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http://dx.doi.org/10.1155/2019/5420624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437739PMC
March 2019
2 Reads

Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile.

Front Immunol 2019 2;10:610. Epub 2019 Apr 2.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Currently, inflammatory bowel disease (IBD) is a serious public health problem on the rise worldwide. In this work, we utilized the zebrafish to introduce a new model of intestinal inflammation triggered by food intake. Taking advantage of the translucency of the larvae and the availability of transgenic zebrafish lines with fluorescently labeled macrophages, neutrophils, or lymphocytes, we studied the behavior of these cell types during the course of inflammation. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00610
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http://dx.doi.org/10.3389/fimmu.2019.00610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454071PMC
April 2019
1 Read

Diverse Large HIV-1 Non-subtype B Clusters Are Spreading Among Men Who Have Sex With Men in Spain.

Front Microbiol 2019 3;10:655. Epub 2019 Apr 3.

HIV Biology and Variability Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.

In Western Europe, the HIV-1 epidemic among men who have sex with men (MSM) is dominated by subtype B. However, recently, other genetic forms have been reported to circulate in this population, as evidenced by their grouping in clusters predominantly comprising European individuals. Here we describe four large HIV-1 non-subtype B clusters spreading among MSM in Spain. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457325PMC

Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes.

Sci Rep 2019 Apr 18;9(1):6274. Epub 2019 Apr 18.

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.

We aimed to explore the relationship between GLP-1 receptor (GLP-1R) expression in adipose tissue (AT) and incretin secretion, glucose homeostasis and weight loss, in patients with morbid obesity and type 2 diabetes undergoing bariatric surgery. RNA was extracted from subcutaneous (SAT) and visceral (VAT) AT biopsies from 40 patients randomized to metabolic gastric bypass, sleeve gastrectomy or greater curvature plication. Biochemical parameters, fasting plasma insulin, glucagon and area under the curve (AUC) of GLP-1 following a standard meal test were determined before and 1 year after bariatric surgery. Read More

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http://dx.doi.org/10.1038/s41598-019-42770-1DOI Listing

Genomic Islands in the Full-Genome Sequence of an NAD-Hemin-Independent Avibacterium paragallinarum Strain Isolated from Peru.

Microbiol Resour Announc 2019 Apr 18;8(16). Epub 2019 Apr 18.

Laboratorios de Investigación y Desarrollo, FARVET, Chincha Alta, Ica, Peru.

Here, we report the full-genome sequence of an NAD-hemin-independent serovar C-2 strain, FARPER-174, isolated from layer hens in Peru. This genome contained 12 potential genomic islands that include ribosomal protein-coding genes, a gene, hemocin-coding genes, sequences of fagos, an operon, and drug resistance genes. Read More

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http://dx.doi.org/10.1128/MRA.00118-19DOI Listing

Prevalence and factors associated with statin use in high-risk patients with type 1 diabetes from a specialized diabetes unit.

Endocrinol Diabetes Nutr 2019 Apr 15. Epub 2019 Apr 15.

Endocrinology and Nutrition Department, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Introduction: The use of statins in non-selected type 1 diabetes (T1D) populations is low. We assessed the prevalence and factors associated with statin treatment in patients meeting criteria for this therapy for primary prevention of cardiovascular disease (CVD).

Material And Methods: From 2015 to 2018, T1D patients from a tertiary hospital were selected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164193005
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http://dx.doi.org/10.1016/j.endinu.2019.02.004DOI Listing
April 2019
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Association Between Subglottic Pressure and Pulmonary Function in Individuals With Parkinson's Disease.

J Voice 2019 Apr 15. Epub 2019 Apr 15.

Facultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Santiago, Chile. Electronic address:

Introduction: In individuals with Parkinson's disease (PD), pulmonary complication such as weakness and rigidity of respiratory muscles and reduced cough airflow may be associated with reduced voice production due to limited pulmonary capacity and reduced airflow needed to vibrate the vocal folds. It is not clear, however, which pulmonary function parameter is determinant in the association with peak subglottic pressure (SGP). Therefore, the purpose of this study was to determine the association between peak SGP and pulmonary function parameters in individuals with PD. Read More

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http://dx.doi.org/10.1016/j.jvoice.2019.03.001DOI Listing

[Influence of diagnostic pathway on clinical and non-conventional therapies use in women with breast cancer of the cohort DAMA].

Gac Sanit 2019 Apr 15. Epub 2019 Apr 15.

Agència de Salut Pública de Barcelona, Barcelona, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España; Institut de Recerca Biomèdica Sant Pau, Barcelona, España.

Objective: To describe and analyze the characteristics of breast cancer tumours according to the diagnostic pathway. We analyse the adverse effects of the treatments and the use of unconventional therapies in order to alleviate them.

Method: Descriptive design nested in a mixed cohort (Cohort DAMA). Read More

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http://dx.doi.org/10.1016/j.gaceta.2019.02.006DOI Listing

Perineural Invasion in Cutaneous Squamous Cell Carcinoma.

Actas Dermosifiliogr 2019 Apr 15. Epub 2019 Apr 15.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

Cutaneous squamous cell carcinoma is sometimes characterized by an increased risk of locoregional recurrence and occasionally distant metastasis. Several clinical and pathological factors, including perineural invasion, have been shown to have prognostic value in this setting. Perineural invasion, that is, the spread of tumor cells into the space surrounding a nerve, is usually an incidental finding. Read More

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http://dx.doi.org/10.1016/j.ad.2018.10.006DOI Listing

Correction to: Evaluation of the mortality registry in Ecuador (2001-2013) - social and geographical inequalities in completeness and quality.

Popul Health Metr 2019 Apr 18;17(1). Epub 2019 Apr 18.

Agència de Salut Pública de Barcelona, Plaça Lesseps 1, 08023, Barcelona, Catalonia, Spain.

Following the publication of this article [1], the authors reported a typesetting error in Table 1 that caused the columns of the table to be ordered incorrectly, and a typographical error in a sentence in the Conclusions section. Read More

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http://dx.doi.org/10.1186/s12963-019-0185-9DOI Listing

Inequalities in health-related quality of life according to age, gender, educational level, social class, body mass index and chronic diseases using the Spanish value set for Euroquol 5D-5L questionnaire.

Health Qual Life Outcomes 2019 Apr 18;17(1):69. Epub 2019 Apr 18.

Unidad de Investigación AP-OSIs Gipuzkoa, Hospital Alto Deba, Avda Navarra 16, Arrasate-Mondragón, 20500, Gipuzkoa, Spain.

Background: Reducing health inequalities on the basis of social factors has been a key driver in the development of Public Health policies. Health-related quality of life is a global indicator useful to assess health inequalities within a society. The objective of this study was to identify inequalities on health by analysing the interactive effects of gender, age, educational level, social class, body mass index and chronic diseases on health-related quality of life in a Spanish population sample. Read More

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http://dx.doi.org/10.1186/s12955-019-1134-9DOI Listing

Temporal and Cartographic Analyses of the Distribution within Spain of Mortality Due to Granulomatosis with Polyangiitis (1984⁻2016).

Int J Environ Res Public Health 2019 Apr 17;16(8). Epub 2019 Apr 17.

Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain.

The aim is to conduct a descriptive, population-based study in order to assess temporal and spatial changes in mortality due to granulomatosis with polyangiitis (GPA) in Spain from 1984 to 2016. Mortality data were obtained from the Spanish Annual Death Registry. Deaths in which GPA was the underlying cause were selected using the 446. Read More

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http://dx.doi.org/10.3390/ijerph16081388DOI Listing

EGFR and KRAS Mutations in the Non-Tumoral Lung. Prognosis in Patients with Adenocarcinoma.

J Clin Med 2019 Apr 17;8(4). Epub 2019 Apr 17.

Respiratory Medicine Department, Hospital del Mar, 08003 Barcelona, Spain.

Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout the exposed lung.

Objective: To analyze whether the most prevalent mutations observed in ADC can also be observed in the non-neoplastic lung tissue, as well as the short-term prognosis implications of this finding. Read More

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https://www.mdpi.com/2077-0383/8/4/529
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http://dx.doi.org/10.3390/jcm8040529DOI Listing
April 2019
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QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Laboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.

We report the synthesis and relevant pharmacological properties of the quinoxalinetacrine (QT) hybrid in a project targeted to identify new non-hepatotoxic tacrine derivatives for Alzheimer's disease therapy. We have found that is less toxic than tacrine at high concentrations (from 100 μM to 1 mM), less potent than tacrine as a ChE inhibitor, but shows selective BuChE inhibition (IC (hAChE) = 22.0 ± 1. Read More

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http://dx.doi.org/10.3390/molecules24081503DOI Listing

A Feasible, Simple, Cost-saving Program to End Cardiovascular Disease in the United States.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Division of Endocrinology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029343193032
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http://dx.doi.org/10.1016/j.amjmed.2019.03.043DOI Listing
April 2019
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Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Objectives: To determine whether circulating endothelial cells from septic shock patients and from nonseptic shock patients are transformed in activated fibroblast by changing the expression level of endothelial and fibrotic proteins, whether the level of the protein expression change is associated with the amount of administered resuscitation fluid, and whether this circulating endothelial cell protein expression change is a biomarker to predict sepsis survival.

Design: Prospective study.

Setting: Medical-surgical ICUs in a tertiary care hospital. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003778DOI Listing

Antipsychotics in the general population and the driver population: comparisons from a population-based registry study.

Int Clin Psychopharmacol 2019 Apr 15. Epub 2019 Apr 15.

Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Valladolid.

Antipsychotics are considered driving-impairing medicines. A population-based registry study design was conceived to assess the year-2016 antipsychotic dispensation in Castile and León, Spain. Weighting was performed to obtain the adjusted antipsychotic consumption for licensed drivers according to age and gender using the Spanish national drivers' license census data. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000263DOI Listing

Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs ().

Heliyon 2019 Apr 5;5(4):e01432. Epub 2019 Apr 5.

Escuela de Medicina Veterinaria, Facultad de Ciencias de la Salud, Universidad de Las Américas, Colimes y Granados 170513, Ecuador.

Bone alterations due to metabolic bone disease in captive animal populations can have a negative impact on repopulation and research initiatives. This investigation has the purpose of describing the principal radiographic and anatomopathological findings present in nine gliding leaf frogs () kept in captivity with alterations in their spines and long bones. The observed histopathological findings were in the canalis vertebralis, paraspinal muscle and long bones, and included deformed bones with alteration of the adjacent tissues, alterations in the ossification process, bone degeneration and resorption, decreased number of osteocytes and deposition of osteoid and fibrous material in the compact bone tissue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183305
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http://dx.doi.org/10.1016/j.heliyon.2019.e01432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451164PMC
April 2019
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Immunoescape the link between emphysema and lung cancer?

J Thorac Dis 2019 Mar;11(Suppl 3):S329-S330

Institut d´Investigació Sanitària de les Illes Balears (IdISBa), Palma de Mallorca, Spain.

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http://jtd.amegroups.com/article/view/26403/20225
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http://dx.doi.org/10.21037/jtd.2018.12.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424755PMC
March 2019
1 Read

Severe aortic regurgitation in a quadricuspid aortic valve: A false rheumatic disease.

Clin Case Rep 2019 Apr 19;7(4):841-843. Epub 2019 Feb 19.

Department of Cardiology Hospital Universitario de Canarias Tenerife Spain.

The quadricuspid aortic valve (QAV) is a malformation that leads to severe valve failure later in life. Malformation and displacement of coronary ostia are found in 10% of patients. In this context, transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) are the essential imaging tests for the preoperative assessment for cardiac surgery. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2060
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http://dx.doi.org/10.1002/ccr3.2060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452453PMC
April 2019
2 Reads

Reliability and reproducibility of a rodent model of choroidal neovascularization based on the subretinal injection of polyethylene glycol.

Mol Vis 2019 18;25:194-203. Epub 2019 Mar 18.

Instituto Universitario de Oftalmobiología Aplicada (IOBA), University of Valladolid, Valladolid, Spain.

Purpose: To evaluate the reliability and reproducibility of a rodent choroidal neovascularization (CNV) model by subretinal injection of polyethylene glycol (PEG).

Methods: C57BL/6 mice were injected subretinally with 2 μl PBS (Gibco, Invitrogen, Paisley, UK; n=14) or PEG (1 mg; n=18). Animals were sacrificed at either 0, 5, 14 or 21 days. Read More

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Prevention of hatching of porcine morulae and blastocysts by liquid storage at 20 °C.

Sci Rep 2019 Apr 17;9(1):6219. Epub 2019 Apr 17.

Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, 30100, Murcia, Spain.

Vitrification is the ideal method for long-lasting storage of porcine embryos. However, both strict airline regulations for transport of liquid nitrogen dewars and the technical problems experienced when vitrified embryos are transferred using non-surgical procedures have led to the introduction of alternative storage methods, such as preserving embryos in liquid state. This study evaluated whether a pH-stable medium containing high concentrations of either foetal calf serum (FCS; 50%) or BSA (4%) combined with storage at temperatures of 17 °C or 20 °C maintained in vivo-derived morulae and blastocysts alive and unhatched (a sanitary requirement for embryo transportation) during 72 h of storage. Read More

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http://www.nature.com/articles/s41598-019-42712-x
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http://dx.doi.org/10.1038/s41598-019-42712-xDOI Listing
April 2019
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Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling.

Sci Rep 2019 Apr 17;9(1):6199. Epub 2019 Apr 17.

Group of Applied Mechanics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain.

The tumour microenvironment (TME) has recently drawn much attention due to its profound impact on tumour development, drug resistance and patient outcome. There is an increasing interest in new therapies that target the TME. Nonetheless, most established in vitro models fail to include essential cues of the TME. Read More

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http://www.nature.com/articles/s41598-019-42529-8
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http://dx.doi.org/10.1038/s41598-019-42529-8DOI Listing
April 2019
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Author Correction: Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size.

Sci Rep 2019 Apr 17;9(1):6395. Epub 2019 Apr 17.

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Departament de Medicina, Barcelona, Spain.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42591-2DOI Listing

A Live Vaccine Delivering PcrV through the Type III Secretion System Protects against Pseudomonas aeruginosa.

mSphere 2019 Apr 17;4(2). Epub 2019 Apr 17.

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain

is a common Gram-negative opportunistic pathogen that is intrinsically resistant to a wide range of antibiotics. The development of a broadly protective vaccine against remains a major challenge. Here, we used an attenuated strain of serovar Typhimurium as a vehicle to express antigens. Read More

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http://dx.doi.org/10.1128/mSphere.00116-19DOI Listing

Beyond Fever and Pain: Diagnostic Methods for Chikungunya Virus.

J Clin Microbiol 2019 Apr 17. Epub 2019 Apr 17.

Emory University, Department of Medicine, Division of Infectious Diseases, Atlanta, GA, USA

Chikungunya virus (CHIKV) is an alphavirus that is primarily transmitted by species mosquitoes. Though reports of an illness consistent with chikungunya date back over 200 years, CHIKV only gained worldwide attention during a massive pandemic that began in East Africa in 2004. Chikungunya, the clinical illness cause by CHIKV, is characterized by a rapid onset of high fever and debilitating joint pain, though in practice, etiologic confirmation of CHIKV requires the availability and use of specific laboratory diagnostics. Read More

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http://jcm.asm.org/lookup/doi/10.1128/JCM.00350-19
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http://dx.doi.org/10.1128/JCM.00350-19DOI Listing
April 2019
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Association between emergency department length of stay and adverse perioperative outcomes in emergency surgery: a cohort study in two Colombian University hospitals.

BMC Emerg Med 2019 Apr 17;19(1):27. Epub 2019 Apr 17.

Grupo de Cardiología Preventiva, Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.

Background: In low- and middle-income countries emergency surgery represents a higher proportion of the total number of surgeries and is associated with greater morbidity/mortality. Study aims were to determine if emergency department length of stay (ED-LOS) was associated with adverse perioperative outcomes and if such association varied across patient's risk categories.

Methods: A retrospective cohort study was conducted of adult patients who underwent orthopedic or abdominal emergency surgery at two Colombian University hospitals. Read More

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https://bmcemergmed.biomedcentral.com/articles/10.1186/s1287
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http://dx.doi.org/10.1186/s12873-019-0241-6DOI Listing
April 2019
1 Read

Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes.

Orphanet J Rare Dis 2019 Apr 17;14(1):82. Epub 2019 Apr 17.

Instituto de Investigaciones Biomedicas CSIC/UAM, IDIPaz, Arturo Duperier, 4, 28029, Madrid, Spain.

Background: Telomeres are nucleoprotein structures present at the terminal region of the chromosomes. Mutations in genes coding for proteins involved in telomere maintenance are causative of a number of disorders known as telomeropathies. The genetic origin of these diseases is heterogeneous and has not been determined for a significant proportion of patients. Read More

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https://ojrd.biomedcentral.com/articles/10.1186/s13023-019-1
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http://dx.doi.org/10.1186/s13023-019-1046-0DOI Listing
April 2019
4 Reads

Multicomponent exercise and the hallmarks of frailty: Considerations on cognitive impairment and acute hospitalization.

Exp Gerontol 2019 Apr 14. Epub 2019 Apr 14.

Department of Health Sciences, Navarrabiomed, IdiSNA, CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Public University of Navarra, Pamplona, Navarra, Spain. Electronic address:

Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living. On the other hand, physical exercise interventions induce marked improvements in frailty physical hallmarks (e.g. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.007DOI Listing

Maternal Cell Phone Use During Pregnancy, Pregnancy Duration And Fetal Growth In Four Birth Cohorts.

Am J Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

Previous studies evaluating potential effects of prenatal exposure to radiofrequency fields from cell phones on birth outcomes are inconsistent. We explored if maternal cell phone use was associated with pregnancy duration and fetal growth. We used information from 55,507 pregnant women and their children from Denmark (1996-2002), the Netherlands (2003-2004), Spain (2003-2008) and Korea (2006-2011). Read More

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http://dx.doi.org/10.1093/aje/kwz092DOI Listing

Geographic shifts in Aedes aegypti habitat suitability in Ecuador using larval surveillance data and ecological niche modeling: Implications of climate change for public health vector control.

PLoS Negl Trop Dis 2019 Apr 17;13(4):e0007322. Epub 2019 Apr 17.

Quantitative Disease Ecology and Conservation (QDEC) Lab Group, Department of Geography, University of Florida, Gainesville, Florida, United States of America.

Arboviral disease transmission by Aedes mosquitoes poses a major challenge to public health systems in Ecuador, where constraints on health services and resource allocation call for spatially informed management decisions. Employing a unique dataset of larval occurrence records provided by the Ecuadorian Ministry of Health, we used ecological niche models (ENMs) to estimate the current geographic distribution of Aedes aegypti in Ecuador, using mosquito presence as a proxy for risk of disease transmission. ENMs built with the Genetic Algorithm for Rule-Set Production (GARP) algorithm and a suite of environmental variables were assessed for agreement and accuracy. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007322
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http://dx.doi.org/10.1371/journal.pntd.0007322DOI Listing
April 2019
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GLP-1 induces alpha cell proliferation and overrides leptin suppression induced by negative energy balance in vagotomized rats.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Endocrine, Cardiovascular & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

Glucagon-like peptide-1 (GLP-1) influences energy balance by exerting effects on food intake and glucose metabolism, through mechanisms that are partially dependent on the vagal pathway. The aim of this study was to characterize the effects of chronic GLP-1 stimulation on energy homeostasis and glucose metabolism in the absence of vagal innervation Truncal vagotomized (VGX) and sham operated rats (SHAM) received an intraperitoneal GLP-1 infusion (3.5 pmol/kg/min) trough mini-osmotic pumps. Read More

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http://dx.doi.org/10.1002/jcb.28719DOI Listing

Graph-Based data integration from bioactive peptide databases of pharmaceutical interest: towards an organized collection enabling visual network analysis.

Bioinformatics 2019 Apr 17. Epub 2019 Apr 17.

Departamento de Ciencias de la Computación, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Baja California, Mexico.

Motivation: Bioactive peptides have gained great attention in the academy and pharmaceutical industry since they play an important role in human health. However, the increasing number of bioactive peptide databases is causing the problem of data redundancy and duplicated efforts. Even worse is the fact that the available data is non-standardized and often dirty with data entry errors. Read More

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http://dx.doi.org/10.1093/bioinformatics/btz260DOI Listing

Workshop for priority-setting in Aedes aegypti control interventions in Latin America and the Caribbean: a policy dialogue.

Cad Saude Publica 2019 8;35(4):e00092918. Epub 2019 Apr 8.

Hospital Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina.

This article presents the results of a dialogue between decision-makers and experts in Latin America and the Caribbean on priority-setting for interventions and studies on Aedes aegypti control. The article is part of a project that included a systematic review of mosquito control strategies and a qualitative study with key informants from the region. Using a collective deliberative process assisted by the results of the above-mentioned projects, a list of priorities was developed by consensus for the implementation of vector control strategies and the development of key regional research lines. Read More

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http://dx.doi.org/10.1590/0102-311X00092918DOI Listing

A Computer Application to Predict Adverse Events in the Short-Term Evolution of Patients With Exacerbation of Chronic Obstructive Pulmonary Disease.

JMIR Med Inform 2019 Apr 17;7(2):e10773. Epub 2019 Apr 17.

Red de Investigación en Servicios Sanitarios en Enfermedades Crónicas, Galdakao, Spain.

Background: Chronic obstructive pulmonary disease (COPD) is a common chronic disease. Exacerbations of COPD (eCOPD) contribute to the worsening of the disease and the patient's evolution. There are some clinical prediction rules that may help to stratify patients with eCOPD by their risk of poor evolution or adverse events. Read More

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http://dx.doi.org/10.2196/10773DOI Listing

High-flow nasal cannula oxygenation reduces postoperative hypoxemia in morbidly obese patients: a randomized controlled trial.

Minerva Anestesiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology & Critical Care, Hospital Clínico Universitario, Valencia, Spain.

Background: Postoperative pulmonary complications (PPCs) are common in high-risk surgical patients. Postoperative ventilatory management may improve their outcomes. Supplemental oxygen through a high-flow nasal cannula (HFNC) has become an alternative to classical oxygenation techniques, although the results published for postoperative patients are contradictory. Read More

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http://dx.doi.org/10.23736/S0375-9393.19.13364-0DOI Listing

Daily Variations in the Expression of Genes Related to Insecticide Resistance in the Chagas Disease Vector (Hemiptera: Reduviidae).

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Instituto de Investigaciones en Ciencias de la Salud (INICSA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Pyrethroid resistance has been detected in , which in part has been attributed to increased oxidative metabolism of the insecticide by cytochrome P450s. Nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome P450 reductase (CPR) catalyzes electron transfer from NADPH to all known cytochrome P450s. In this study, the expression of the gene at transcriptional level was determined in different tissues and two life stages. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0155DOI Listing

Exploring the Use of Technology for Sexual Health Risk-Reduction among Ecuadorean Adolescents.

Ann Glob Health 2019 Apr 15;85(1). Epub 2019 Apr 15.

Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, EC.

Background: There is a lack of sexual health knowledge and resource access among youth in Latin America, along with rising rates of teenage pregnancy and STD transmission.

Objective: To determine baseline sexual health knowledge and the acceptance of a technology based sexual health risk-reduction program among Ecuadorean adolescents.

Methods: We used mixed methods to determine the sexual health knowledge and practices, and technology use among 204 adolescents from two schools in Cumbayá and Lumbisí, Ecuador. Read More

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https://agh.ubiquitypress.com/articles/10.5334/aogh.35/
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http://dx.doi.org/10.5334/aogh.35DOI Listing
April 2019
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Disparities in the management of cutaneous malignant melanoma. A population-based high-resolution study.

Eur J Cancer Care (Engl) 2019 Apr 16:e13043. Epub 2019 Apr 16.

Navarra Public Health Institute - IdiSNA, Pamplona, Spain.

Population-based cancer registry data from three Spanish areas were used to assess the patterns of care and adherence to guidelines for cutaneous malignant melanoma. We included 934 cases diagnosed in 2009-2013. Completeness of the pathology reports, imaging for detecting distant metastasis and the use of sentinel lymph node biopsy (SLNB) were analysed. Read More

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http://dx.doi.org/10.1111/ecc.13043DOI Listing

Role of Physical Activity and Sedentary Behavior in the Mental Health of Preschoolers, Children and Adolescents: A Systematic Review and Meta-Analysis.

Sports Med 2019 Apr 16. Epub 2019 Apr 16.

PROFITH "PROmoting FITness and Health through physical activity" research group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.

Background: Evidence suggests that participation in physical activity may support young people's current and future mental health. Although previous reviews have examined the relationship between physical activity and a range of mental health outcomes in children and adolescents, due to the large increase in published studies there is a need for an update and quantitative synthesis of effects.

Objectives: The objectives of this study were to determine the effect of physical activity interventions on mental health outcomes by conducting a systematic review and meta-analysis, and to systematically synthesize the observational evidence (both longitudinal and cross-sectional studies) regarding the associations between physical activity and sedentary behavior and mental health in preschoolers (2-5 years of age), children (6-11 years of age) and adolescents (12-18 years of age). Read More

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http://dx.doi.org/10.1007/s40279-019-01099-5DOI Listing

Pre-marital predictors of marital violence in the WHO World Mental Health (WMH) Surveys.

Soc Psychiatry Psychiatr Epidemiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Behavioral Medicine and Psychiatry, School of Medicine, West Virginia University, 64 Medical Center Drive, Morgantown, WV, 26506, USA.

Purpose: Intimate partner violence (IPV) is a pervasive public health problem. Existing research has focused on reports from victims and few studies have considered pre-marital factors. The main objective of this study was to identify pre-marital predictors of IPV in the current marriage using information obtained from husbands and wives. Read More

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http://link.springer.com/10.1007/s00127-019-01703-z
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http://dx.doi.org/10.1007/s00127-019-01703-zDOI Listing
April 2019
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Clinical and laboratory features of anti-MAG neuropathy without monoclonal gammopathy.

Sci Rep 2019 Apr 16;9(1):6155. Epub 2019 Apr 16.

Neuromuscular Diseases Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Antibodies against myelin-associated glycoprotein (MAG) almost invariably appear in the context of an IgM monoclonal gammopathy associated neuropathy. Very few cases of anti-MAG neuropathy lacking IgM-monoclonal gammopathy have been reported. We investigated the presence of anti-MAG antibodies in 69 patients fulfilling diagnostic criteria for CIDP. Read More

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http://www.nature.com/articles/s41598-019-42545-8
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http://dx.doi.org/10.1038/s41598-019-42545-8DOI Listing
April 2019
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