63,218 results match your criteria Salud Ciencia[Journal]


Effect of single and combined chemical and physical treatments on the survival of Salmonella and Escherichia coli O157:H7 attached to Valencia oranges.

Int J Food Microbiol 2019 Apr 12;300:22-30. Epub 2019 Apr 12.

Departamentos de Farmacobiología y Matemáticas, CUCEI, Universidad de Guadalajara, Guadalajara, Jalisco 44430, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.ijfoodmicro.2019.04.001DOI Listing

Evaluation of two approaches to lysosomal acid lipase deficiency patient identification: An observational retrospective study.

Atherosclerosis 2019 Mar 18;285:49-54. Epub 2019 Mar 18.

Instituto de Investigación Sanitaria Aragón (IIS Aragón), GIIS-012, Zaragoza, 50009, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), CB/06/07/1036, Instituto de Salud Carlos III (ISCIII), Hospital Universitario Miguel Servet, Zaragoza, 50009, Spain; Fundación Española para el Estudio y Terapéutica de la Enfermedad de Gaucher y Otras Lisosomales (FEETEG), Zaragoza, 50008, Spain.

Background And Aims: Lysosomal acid lipase deficiency (LALD) leads to the accumulation of cholesteryl esters and/or triglycerides (TG) in lysosomes due to the lack of the enzyme codified by the LIPA gene. The most common symptoms are dyslipidaemia and hypertransaminasemia, together with manifestations common to other lysosomal storage disorders (LSDs), including visceromegalies and elevated plasma biomarkers. Alteration of the lipid-liver profile (LLP) has been widely applied as a criterion for LALD screening, but the usefulness of biomarkers has not yet been explored. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.013DOI Listing

Integrating Bleeding Control Training Into Surgical Missions in Low- and Middle-Income Countries.

J Surg Res 2019 Apr 17;241:53-56. Epub 2019 Apr 17.

Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.

Background: Basic bleeding control (BCon) techniques can save lives globally but the knowledge is not widespread in low-income countries where trauma is a common cause of death. Short-term surgical missions (STSMs) are an effective route to share this public health initiative around the world.

Materials And Methods: Over 2017-2018, the International Surgical Health Initiative organized STSMs to locations in Sierra Leone, Bangladesh, Peru, and Ghana. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.020DOI Listing

Low-cost internal controls for detection of Giardia cysts in water samples.

Parasitol Int 2019 Apr 17. Epub 2019 Apr 17.

Sección Infección Nutrición, Instituto de Investigaciones en Salud (INISA), Universidad de Costa Rica, 11501-2060 San José, Costa Rica.

Giardia cysts stained with hot carbolfuchsin were used as internal controls in a concentration method for surface water samples. The morphological integrity of stained cysts and the stain's stability and intensity weretested with each of the chemical reagents used in the aluminum sulfate flocculation method. No alterations in morphology or color were noted. Read More

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http://dx.doi.org/10.1016/j.parint.2019.04.012DOI Listing

Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions.

Biotechnol Adv 2019 Apr 17. Epub 2019 Apr 17.

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau. Electronic address:

The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.007DOI Listing

Role of Leptin in the Association Between Body Adiposity and Persistent Asthma: A Longitudinal Study.

Obesity (Silver Spring) 2019 Apr 20. Epub 2019 Apr 20.

VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, INSERM U1168, Villejuif, France.

Objective: Obesity is a likely risk factor for asthma. However, underlying mechanisms by which obesity affects asthma activity remain poorly understood. This study aimed to investigate the role of leptin, an adipocyte-derived proinflammatory protein, as a mediator in the association between body adiposity (assessed using BMI, waist circumference, and body fat percentage) and persistent asthma. Read More

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http://dx.doi.org/10.1002/oby.22466DOI Listing

Association between restless legs syndrome and other movement disorders.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Section of Neurology (H.A.-N., F.J.J.-J.), Hospital Universitario del Sureste, Arganda del Rey, Madrid; and University Institute of Molecular Pathology Biomarkers (E.G.-M., J.A.G.A), UNEx, ARADyAL Instituto de Salud Carlos III, Cáceres, Spain.

Objective: This review focuses on the possible association between restless legs syndrome (RLS) and movement disorders, including Parkinson disease (PD), other parkinsonian syndromes, essential tremor, choreic and dystonic syndromes, Tourette syndrome, and heredodegenerative ataxias.

Methods: Review of PubMed from 1966 to September 2018 and identification of references of interest for the topic. A meta-analysis of eligible studies on the frequency of RLS in patients with PD and controls using Meta-DiSc1. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007500DOI Listing

A novel mutation in the gene expands the phenotype of Alexander disease.

J Med Genet 2019 Apr 19. Epub 2019 Apr 19.

Neurometabolic Diseases Laboratory, Institut d'Investigacio Biomedica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat (Barcelona), Catalonia, Spain

Background: Alexander disease, an autosomal dominant leukodystrophy, is caused by missense mutations in . Although mostly diagnosed in children, associated with severe leukoencephalopathy, milder adult forms also exist.

Methods: A family affected by adult-onset spastic paraplegia underwent neurological examination and cerebral MRI. Read More

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2018-105959
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http://dx.doi.org/10.1136/jmedgenet-2018-105959DOI Listing
April 2019
1 Read

Assessment of analgesia, sedation, physical restraint and delirium in patients admitted to Spanish intensive care units. Proyecto ASCyD.

Enferm Intensiva 2019 Apr 16. Epub 2019 Apr 16.

Grupo de Trabajo de Analgesia, Sedación, Contenciones y Delirio de la Sociedad Española de Enfermería Intensiva y Unidades Coronarias (GT-ASCyD-SEEIUC), España; Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, España; Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA), Majadahonda, Madrid, España.

Aims: Main aim: To determine the Spanish intensive care units (ICU) that assess and record pain levels, sedation/agitation, delirium and the use of physical restraint (PR) as standard practice. Secondary aims: To determine the use of validated assessment tools and to explore patients' levels of pain and sedation/agitation, the prevalence of delirium, and the use of PR.

Method: An observational, descriptive, cross-sectional, prospective and multicentre study using an ad hoc survey with online access that consisted of 2 blocks. Read More

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http://dx.doi.org/10.1016/j.enfi.2018.11.002DOI Listing

Clinical guide for the diagnosis and follow-up of myotonic dystrophy type 1, MD1 or Steinert's disease.

Neurologia 2019 Apr 16. Epub 2019 Apr 16.

Servicio de Neurología, Hospital Universitario 12 de Octubre, Madrid, España.

Background And Objectives: Steinert's disease or myotonic dystrophy type 1 (MD1), (OMIM 160900), is the most prevalent myopathy in adults. It is a multisystemic disorder with dysfunction of virtually all organs and tissues and a great phenotypical variability, which implies that it has to be addressed by different specialities with experience in the disease. The knowledge of the disease and its management has changed dramatically in recent years. Read More

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http://dx.doi.org/10.1016/j.nrl.2019.01.001DOI Listing

Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial.

Lancet Diabetes Endocrinol 2019 May;7(5):e6-e17

Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Internal Medicine and Lipid Clinic, Department of Endocrinology and Nutrition, University of Barcelona, Barcelona, Spain.

Background: Because of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese.

Methods: PREDIMED was a 5 year parallel-group, multicentre, randomised, controlled clinical trial done in primary care centres affiliated to 11 hospitals in Spain. Read More

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http://dx.doi.org/10.1016/S2213-8587(19)30074-9DOI Listing

Drug Susceptibility Testing and Synergistic Antibacterial Activity of Curcumin with Antibiotics against Enterotoxigenic .

Antibiotics (Basel) 2019 Apr 18;8(2). Epub 2019 Apr 18.

Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Calle Sierra Mojada 950, Independencia Oriente, Guadalajara 44340, Jalisco, Mexico.

This study investigated the susceptibility of Enterotoxigenic to curcumin, as well as its synergistic effect with 12 antimicrobial drugs. Our study shows that curcumin did not affect bacterial growth. The antimicrobial susceptibility of curcumin and antibiotic synergy were identified using disc diffusion on Mueller-Hinton agar. Read More

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http://dx.doi.org/10.3390/antibiotics8020043DOI Listing

QSAR modelling for predicting the toxic effects of traditional and derived biomass solvents on a Danio rerio biomodel.

Chemosphere 2019 Apr 10;227:480-488. Epub 2019 Apr 10.

Universidad San Jorge, Campus Universitario, Autov A23 Km 299, 50830, Villanueva de Gállego, Zaragoza, Spain. Electronic address:

The increasing interest in the development of ecofriendly solvents has led to the synthesis of benign alternative chemicals with minimized environmental impacts. These kinds of chemicals are known as Green solvents. In this work, we selected three families of solvents (furfural, lactate and levulinate families) derived from biomass that are structurally related. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.054DOI Listing

Spotlight on epigenetic reprogramming in cardiac regeneration.

Semin Cell Dev Biol 2019 Apr 16. Epub 2019 Apr 16.

Heart Failure and Cardiac Regeneration (ICREC) Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Carretera Canyet, s/n, Camí de les Escoles, s/n, 08916 Badalona, Spain; CIBERCV, Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029 Madrid, Spain; Cardiology Service, HUGTiP, Carretera Canyet, s/n, 08916 Badalona, Spain; Department of Medicine, Barcelona Autonomous University (UAB), Carretera Canyet, s/n, Camí de les Escoles, s/n, 08916 Badalona, Spain.

Heart failure of ischemic origin is caused by the presence of a large scar resulting from an acute myocardial infarction. Acute myocardial infarction generally occurs when blood supply to the heart is blocked. Regenerative strategies that limit infarct injury would be able to prevent adverse post-ischemic remodelling and maintain the structural support necessary for effective cardiomyocyte contraction. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.009DOI Listing
April 2019
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Comparison of Risk of Osteoporotic Fracture in Denosumab vs Alendronate Treatment Within 3 Years of Initiation.

JAMA Netw Open 2019 Apr 5;2(4):e192416. Epub 2019 Apr 5.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Importance: Head-to-head randomized clinical trials showed greater efficacy of denosumab vs alendronate in improving bone mineral density. Although there is an association of changes in bone mineral density with reductions in fracture risk, the magnitude of the association is not well established.

Objective: To compare the risk of hip and any fracture in patients treated with denosumab and alendronate in routine practice settings. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2416DOI Listing
April 2019
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GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.

Acta Physiol (Oxf) 2019 Apr 19:e13283. Epub 2019 Apr 19.

University of Navarra, Department of Nutrition, Food Science and Physiology, Pamplona, Spain.

Aim: The facilitative glucose transporter GLUT12 was isolated from the breast cancer cell line MCF-7 by its homology with GLUT4. GLUT12 is expressed in insulin sensitive tissues such as adipose tissue. The aim of this work was to investigate GLUT12 expression and hormonal regulation in 3T3-L1 adipocytes and in adipose tissue of lean and diet-induced obese mice. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13283
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http://dx.doi.org/10.1111/apha.13283DOI Listing
April 2019
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Identification of Off-Patent Compounds That Present Antifungal Activity Against the Emerging Fungal Pathogen .

Front Cell Infect Microbiol 2019 2;9:83. Epub 2019 Apr 2.

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.

is an emerging fungal pathogen of great concern among the scientific community because it is causing an increasing number of hospital outbreaks of difficult management worldwide. In addition, isolates from this species frequently present reduced susceptibility to azole and echinocandin drugs. For this reason, it is necessary to develop new antifungal strategies to better control the disease caused by this yeast. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00083
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http://dx.doi.org/10.3389/fcimb.2019.00083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454888PMC
April 2019
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Recent advances in managing/understanding the metabolic syndrome.

F1000Res 2019 3;8. Epub 2019 Apr 3.

Unidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14008, Mexico.

The metabolic syndrome (MetS) concept gathers in a single entity a set of metabolic abnormalities that have in common a close relationship with ectopic deposit of lipids, insulin resistance, and chronic low-grade inflammation. It is a valuable teaching tool to help health professionals to understand and integrate the consequences of lipotoxicity and the adverse metabolic consequences of insulin resistance. Also, it is useful to identify subjects with a high risk for having incident type 2 diabetes. Read More

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https://f1000research.com/articles/8-370/v1
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http://dx.doi.org/10.12688/f1000research.17122.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449786PMC
April 2019
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Nephroprotective Effect of Embryonic Stem Cells Reducing Lipid Peroxidation in Kidney Injury Induced by Cisplatin.

Oxid Med Cell Longev 2019 14;2019:5420624. Epub 2019 Mar 14.

Escuela Militar de Medicina, Centro Militar de Ciencias de la Salud, Secretaria de la Defensa Nacional, Ciudad de México 11200, Mexico.

Introduction: The acute kidney injury (AKI) is characterized by a sudden glomerular filtration reduction. Renal or intrinsic causes of AKI include nephrotoxicity induced by exogenous agents like cisplatin, which causes oxidative stress altering the biochemical process and leading to apoptosis. Therefore, this research is aimed at analyzing the embryonic stem cells (ESC) nephroprotective effect in AKI induced by cisplatin, employing genetic, phenotypic, and microspectroscopic techniques. Read More

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http://dx.doi.org/10.1155/2019/5420624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437739PMC
March 2019
2 Reads

Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile.

Front Immunol 2019 2;10:610. Epub 2019 Apr 2.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Currently, inflammatory bowel disease (IBD) is a serious public health problem on the rise worldwide. In this work, we utilized the zebrafish to introduce a new model of intestinal inflammation triggered by food intake. Taking advantage of the translucency of the larvae and the availability of transgenic zebrafish lines with fluorescently labeled macrophages, neutrophils, or lymphocytes, we studied the behavior of these cell types during the course of inflammation. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00610
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http://dx.doi.org/10.3389/fimmu.2019.00610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454071PMC
April 2019
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Diverse Large HIV-1 Non-subtype B Clusters Are Spreading Among Men Who Have Sex With Men in Spain.

Front Microbiol 2019 3;10:655. Epub 2019 Apr 3.

HIV Biology and Variability Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.

In Western Europe, the HIV-1 epidemic among men who have sex with men (MSM) is dominated by subtype B. However, recently, other genetic forms have been reported to circulate in this population, as evidenced by their grouping in clusters predominantly comprising European individuals. Here we describe four large HIV-1 non-subtype B clusters spreading among MSM in Spain. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457325PMC

Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes.

Sci Rep 2019 Apr 18;9(1):6274. Epub 2019 Apr 18.

CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.

We aimed to explore the relationship between GLP-1 receptor (GLP-1R) expression in adipose tissue (AT) and incretin secretion, glucose homeostasis and weight loss, in patients with morbid obesity and type 2 diabetes undergoing bariatric surgery. RNA was extracted from subcutaneous (SAT) and visceral (VAT) AT biopsies from 40 patients randomized to metabolic gastric bypass, sleeve gastrectomy or greater curvature plication. Biochemical parameters, fasting plasma insulin, glucagon and area under the curve (AUC) of GLP-1 following a standard meal test were determined before and 1 year after bariatric surgery. Read More

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http://dx.doi.org/10.1038/s41598-019-42770-1DOI Listing

Genomic Islands in the Full-Genome Sequence of an NAD-Hemin-Independent Avibacterium paragallinarum Strain Isolated from Peru.

Microbiol Resour Announc 2019 Apr 18;8(16). Epub 2019 Apr 18.

Laboratorios de Investigación y Desarrollo, FARVET, Chincha Alta, Ica, Peru.

Here, we report the full-genome sequence of an NAD-hemin-independent serovar C-2 strain, FARPER-174, isolated from layer hens in Peru. This genome contained 12 potential genomic islands that include ribosomal protein-coding genes, a gene, hemocin-coding genes, sequences of fagos, an operon, and drug resistance genes. Read More

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http://genomea.asm.org/lookup/doi/10.1128/MRA.00118-19
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http://dx.doi.org/10.1128/MRA.00118-19DOI Listing
April 2019
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Prevalence and factors associated with statin use in high-risk patients with type 1 diabetes from a specialized diabetes unit.

Endocrinol Diabetes Nutr 2019 Apr 15. Epub 2019 Apr 15.

Endocrinology and Nutrition Department, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Introduction: The use of statins in non-selected type 1 diabetes (T1D) populations is low. We assessed the prevalence and factors associated with statin treatment in patients meeting criteria for this therapy for primary prevention of cardiovascular disease (CVD).

Material And Methods: From 2015 to 2018, T1D patients from a tertiary hospital were selected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164193005
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http://dx.doi.org/10.1016/j.endinu.2019.02.004DOI Listing
April 2019
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Association Between Subglottic Pressure and Pulmonary Function in Individuals With Parkinson's Disease.

J Voice 2019 Apr 15. Epub 2019 Apr 15.

Facultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Santiago, Chile. Electronic address:

Introduction: In individuals with Parkinson's disease (PD), pulmonary complication such as weakness and rigidity of respiratory muscles and reduced cough airflow may be associated with reduced voice production due to limited pulmonary capacity and reduced airflow needed to vibrate the vocal folds. It is not clear, however, which pulmonary function parameter is determinant in the association with peak subglottic pressure (SGP). Therefore, the purpose of this study was to determine the association between peak SGP and pulmonary function parameters in individuals with PD. Read More

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http://dx.doi.org/10.1016/j.jvoice.2019.03.001DOI Listing

[Influence of diagnostic pathway on clinical and non-conventional therapies use in women with breast cancer of the cohort DAMA].

Gac Sanit 2019 Apr 15. Epub 2019 Apr 15.

Agència de Salut Pública de Barcelona, Barcelona, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España; Institut de Recerca Biomèdica Sant Pau, Barcelona, España.

Objective: To describe and analyze the characteristics of breast cancer tumours according to the diagnostic pathway. We analyse the adverse effects of the treatments and the use of unconventional therapies in order to alleviate them.

Method: Descriptive design nested in a mixed cohort (Cohort DAMA). Read More

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http://dx.doi.org/10.1016/j.gaceta.2019.02.006DOI Listing

Perineural Invasion in Cutaneous Squamous Cell Carcinoma.

Actas Dermosifiliogr 2019 Apr 15. Epub 2019 Apr 15.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

Cutaneous squamous cell carcinoma is sometimes characterized by an increased risk of locoregional recurrence and occasionally distant metastasis. Several clinical and pathological factors, including perineural invasion, have been shown to have prognostic value in this setting. Perineural invasion, that is, the spread of tumor cells into the space surrounding a nerve, is usually an incidental finding. Read More

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http://dx.doi.org/10.1016/j.ad.2018.10.006DOI Listing

Correction to: Evaluation of the mortality registry in Ecuador (2001-2013) - social and geographical inequalities in completeness and quality.

Popul Health Metr 2019 Apr 18;17(1). Epub 2019 Apr 18.

Agència de Salut Pública de Barcelona, Plaça Lesseps 1, 08023, Barcelona, Catalonia, Spain.

Following the publication of this article [1], the authors reported a typesetting error in Table 1 that caused the columns of the table to be ordered incorrectly, and a typographical error in a sentence in the Conclusions section. Read More

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http://dx.doi.org/10.1186/s12963-019-0185-9DOI Listing

Inequalities in health-related quality of life according to age, gender, educational level, social class, body mass index and chronic diseases using the Spanish value set for Euroquol 5D-5L questionnaire.

Health Qual Life Outcomes 2019 Apr 18;17(1):69. Epub 2019 Apr 18.

Unidad de Investigación AP-OSIs Gipuzkoa, Hospital Alto Deba, Avda Navarra 16, Arrasate-Mondragón, 20500, Gipuzkoa, Spain.

Background: Reducing health inequalities on the basis of social factors has been a key driver in the development of Public Health policies. Health-related quality of life is a global indicator useful to assess health inequalities within a society. The objective of this study was to identify inequalities on health by analysing the interactive effects of gender, age, educational level, social class, body mass index and chronic diseases on health-related quality of life in a Spanish population sample. Read More

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http://dx.doi.org/10.1186/s12955-019-1134-9DOI Listing

Temporal and Cartographic Analyses of the Distribution within Spain of Mortality Due to Granulomatosis with Polyangiitis (1984⁻2016).

Int J Environ Res Public Health 2019 Apr 17;16(8). Epub 2019 Apr 17.

Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain.

The aim is to conduct a descriptive, population-based study in order to assess temporal and spatial changes in mortality due to granulomatosis with polyangiitis (GPA) in Spain from 1984 to 2016. Mortality data were obtained from the Spanish Annual Death Registry. Deaths in which GPA was the underlying cause were selected using the 446. Read More

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http://dx.doi.org/10.3390/ijerph16081388DOI Listing

EGFR and KRAS Mutations in the Non-Tumoral Lung. Prognosis in Patients with Adenocarcinoma.

J Clin Med 2019 Apr 17;8(4). Epub 2019 Apr 17.

Respiratory Medicine Department, Hospital del Mar, 08003 Barcelona, Spain.

Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout the exposed lung.

Objective: To analyze whether the most prevalent mutations observed in ADC can also be observed in the non-neoplastic lung tissue, as well as the short-term prognosis implications of this finding. Read More

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https://www.mdpi.com/2077-0383/8/4/529
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http://dx.doi.org/10.3390/jcm8040529DOI Listing
April 2019
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QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Laboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.

We report the synthesis and relevant pharmacological properties of the quinoxalinetacrine (QT) hybrid in a project targeted to identify new non-hepatotoxic tacrine derivatives for Alzheimer's disease therapy. We have found that is less toxic than tacrine at high concentrations (from 100 μM to 1 mM), less potent than tacrine as a ChE inhibitor, but shows selective BuChE inhibition (IC (hAChE) = 22.0 ± 1. Read More

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http://dx.doi.org/10.3390/molecules24081503DOI Listing

A Feasible, Simple, Cost-saving Program to End Cardiovascular Disease in the United States.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Division of Endocrinology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029343193032
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http://dx.doi.org/10.1016/j.amjmed.2019.03.043DOI Listing
April 2019
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Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Objectives: To determine whether circulating endothelial cells from septic shock patients and from nonseptic shock patients are transformed in activated fibroblast by changing the expression level of endothelial and fibrotic proteins, whether the level of the protein expression change is associated with the amount of administered resuscitation fluid, and whether this circulating endothelial cell protein expression change is a biomarker to predict sepsis survival.

Design: Prospective study.

Setting: Medical-surgical ICUs in a tertiary care hospital. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003778DOI Listing

Antipsychotics in the general population and the driver population: comparisons from a population-based registry study.

Int Clin Psychopharmacol 2019 Apr 15. Epub 2019 Apr 15.

Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Valladolid.

Antipsychotics are considered driving-impairing medicines. A population-based registry study design was conceived to assess the year-2016 antipsychotic dispensation in Castile and León, Spain. Weighting was performed to obtain the adjusted antipsychotic consumption for licensed drivers according to age and gender using the Spanish national drivers' license census data. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000263DOI Listing

Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs ().

Heliyon 2019 Apr 5;5(4):e01432. Epub 2019 Apr 5.

Escuela de Medicina Veterinaria, Facultad de Ciencias de la Salud, Universidad de Las Américas, Colimes y Granados 170513, Ecuador.

Bone alterations due to metabolic bone disease in captive animal populations can have a negative impact on repopulation and research initiatives. This investigation has the purpose of describing the principal radiographic and anatomopathological findings present in nine gliding leaf frogs () kept in captivity with alterations in their spines and long bones. The observed histopathological findings were in the canalis vertebralis, paraspinal muscle and long bones, and included deformed bones with alteration of the adjacent tissues, alterations in the ossification process, bone degeneration and resorption, decreased number of osteocytes and deposition of osteoid and fibrous material in the compact bone tissue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183305
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http://dx.doi.org/10.1016/j.heliyon.2019.e01432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451164PMC
April 2019
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Immunoescape the link between emphysema and lung cancer?

J Thorac Dis 2019 Mar;11(Suppl 3):S329-S330

Institut d´Investigació Sanitària de les Illes Balears (IdISBa), Palma de Mallorca, Spain.

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http://jtd.amegroups.com/article/view/26403/20225
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http://dx.doi.org/10.21037/jtd.2018.12.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424755PMC
March 2019
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Severe aortic regurgitation in a quadricuspid aortic valve: A false rheumatic disease.

Clin Case Rep 2019 Apr 19;7(4):841-843. Epub 2019 Feb 19.

Department of Cardiology Hospital Universitario de Canarias Tenerife Spain.

The quadricuspid aortic valve (QAV) is a malformation that leads to severe valve failure later in life. Malformation and displacement of coronary ostia are found in 10% of patients. In this context, transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) are the essential imaging tests for the preoperative assessment for cardiac surgery. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2060
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http://dx.doi.org/10.1002/ccr3.2060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452453PMC
April 2019
2 Reads

Reliability and reproducibility of a rodent model of choroidal neovascularization based on the subretinal injection of polyethylene glycol.

Mol Vis 2019 18;25:194-203. Epub 2019 Mar 18.

Instituto Universitario de Oftalmobiología Aplicada (IOBA), University of Valladolid, Valladolid, Spain.

Purpose: To evaluate the reliability and reproducibility of a rodent choroidal neovascularization (CNV) model by subretinal injection of polyethylene glycol (PEG).

Methods: C57BL/6 mice were injected subretinally with 2 μl PBS (Gibco, Invitrogen, Paisley, UK; n=14) or PEG (1 mg; n=18). Animals were sacrificed at either 0, 5, 14 or 21 days. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441359PMC
March 2019
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Prevention of hatching of porcine morulae and blastocysts by liquid storage at 20 °C.

Sci Rep 2019 Apr 17;9(1):6219. Epub 2019 Apr 17.

Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, International Excellence Campus for Higher Education and Research "Campus Mare Nostrum", University of Murcia, 30100, Murcia, Spain.

Vitrification is the ideal method for long-lasting storage of porcine embryos. However, both strict airline regulations for transport of liquid nitrogen dewars and the technical problems experienced when vitrified embryos are transferred using non-surgical procedures have led to the introduction of alternative storage methods, such as preserving embryos in liquid state. This study evaluated whether a pH-stable medium containing high concentrations of either foetal calf serum (FCS; 50%) or BSA (4%) combined with storage at temperatures of 17 °C or 20 °C maintained in vivo-derived morulae and blastocysts alive and unhatched (a sanitary requirement for embryo transportation) during 72 h of storage. Read More

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http://www.nature.com/articles/s41598-019-42712-x
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http://dx.doi.org/10.1038/s41598-019-42712-xDOI Listing
April 2019
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Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling.

Sci Rep 2019 Apr 17;9(1):6199. Epub 2019 Apr 17.

Group of Applied Mechanics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain.

The tumour microenvironment (TME) has recently drawn much attention due to its profound impact on tumour development, drug resistance and patient outcome. There is an increasing interest in new therapies that target the TME. Nonetheless, most established in vitro models fail to include essential cues of the TME. Read More

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http://www.nature.com/articles/s41598-019-42529-8
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http://dx.doi.org/10.1038/s41598-019-42529-8DOI Listing
April 2019
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Author Correction: Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size.

Sci Rep 2019 Apr 17;9(1):6395. Epub 2019 Apr 17.

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Departament de Medicina, Barcelona, Spain.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42591-2DOI Listing

A Live Vaccine Delivering PcrV through the Type III Secretion System Protects against Pseudomonas aeruginosa.

mSphere 2019 Apr 17;4(2). Epub 2019 Apr 17.

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain

is a common Gram-negative opportunistic pathogen that is intrinsically resistant to a wide range of antibiotics. The development of a broadly protective vaccine against remains a major challenge. Here, we used an attenuated strain of serovar Typhimurium as a vehicle to express antigens. Read More

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http://dx.doi.org/10.1128/mSphere.00116-19DOI Listing
April 2019
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Beyond Fever and Pain: Diagnostic Methods for Chikungunya Virus.

J Clin Microbiol 2019 Apr 17. Epub 2019 Apr 17.

Emory University, Department of Medicine, Division of Infectious Diseases, Atlanta, GA, USA

Chikungunya virus (CHIKV) is an alphavirus that is primarily transmitted by species mosquitoes. Though reports of an illness consistent with chikungunya date back over 200 years, CHIKV only gained worldwide attention during a massive pandemic that began in East Africa in 2004. Chikungunya, the clinical illness cause by CHIKV, is characterized by a rapid onset of high fever and debilitating joint pain, though in practice, etiologic confirmation of CHIKV requires the availability and use of specific laboratory diagnostics. Read More

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http://jcm.asm.org/lookup/doi/10.1128/JCM.00350-19
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http://dx.doi.org/10.1128/JCM.00350-19DOI Listing
April 2019
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Association between emergency department length of stay and adverse perioperative outcomes in emergency surgery: a cohort study in two Colombian University hospitals.

BMC Emerg Med 2019 Apr 17;19(1):27. Epub 2019 Apr 17.

Grupo de Cardiología Preventiva, Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.

Background: In low- and middle-income countries emergency surgery represents a higher proportion of the total number of surgeries and is associated with greater morbidity/mortality. Study aims were to determine if emergency department length of stay (ED-LOS) was associated with adverse perioperative outcomes and if such association varied across patient's risk categories.

Methods: A retrospective cohort study was conducted of adult patients who underwent orthopedic or abdominal emergency surgery at two Colombian University hospitals. Read More

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https://bmcemergmed.biomedcentral.com/articles/10.1186/s1287
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http://dx.doi.org/10.1186/s12873-019-0241-6DOI Listing
April 2019
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Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes.

Orphanet J Rare Dis 2019 Apr 17;14(1):82. Epub 2019 Apr 17.

Instituto de Investigaciones Biomedicas CSIC/UAM, IDIPaz, Arturo Duperier, 4, 28029, Madrid, Spain.

Background: Telomeres are nucleoprotein structures present at the terminal region of the chromosomes. Mutations in genes coding for proteins involved in telomere maintenance are causative of a number of disorders known as telomeropathies. The genetic origin of these diseases is heterogeneous and has not been determined for a significant proportion of patients. Read More

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https://ojrd.biomedcentral.com/articles/10.1186/s13023-019-1
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http://dx.doi.org/10.1186/s13023-019-1046-0DOI Listing
April 2019
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Multicomponent exercise and the hallmarks of frailty: Considerations on cognitive impairment and acute hospitalization.

Exp Gerontol 2019 Apr 14. Epub 2019 Apr 14.

Department of Health Sciences, Navarrabiomed, IdiSNA, CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Public University of Navarra, Pamplona, Navarra, Spain. Electronic address:

Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living. On the other hand, physical exercise interventions induce marked improvements in frailty physical hallmarks (e.g. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.007DOI Listing
April 2019
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Maternal Cell Phone Use During Pregnancy, Pregnancy Duration And Fetal Growth In Four Birth Cohorts.

Am J Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

Previous studies evaluating potential effects of prenatal exposure to radiofrequency fields from cell phones on birth outcomes are inconsistent. We explored if maternal cell phone use was associated with pregnancy duration and fetal growth. We used information from 55,507 pregnant women and their children from Denmark (1996-2002), the Netherlands (2003-2004), Spain (2003-2008) and Korea (2006-2011). Read More

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http://dx.doi.org/10.1093/aje/kwz092DOI Listing
April 2019
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