61,879 results match your criteria Salud Ciencia[Journal]


Prevalence of severe/morbid obesity and other weight status and anthropometric reference standards in Spanish preschool children: The PREFIT project.

Pediatr Res 2019 Feb 18. Epub 2019 Feb 18.

PROFITH "PROmoting FITness and Health through physical activity" research group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.

Background: Childhood obesity has become a major health problem in children under the age of 5 years. Providing reference standards would help paediatricians to detect and/or prevent health problems related to both low and high levels of body mass and to central adiposity later in life. Therefore, the aim of this study was to examine the prevalence of different weight status categories and to provide sex- and age-specific anthropometry reference standards for Spanish preschool children. Read More

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http://dx.doi.org/10.1038/s41390-019-0325-8DOI Listing
February 2019

Non-pharmacological therapies for depressive symptoms in breast cancer patients: Systematic review and meta-analysis of randomized clinical trials.

Breast 2019 Jan 31;44:135-143. Epub 2019 Jan 31.

DPH, Instituto Nacional de Salud Pública, Av. Universidad 655, Sta. Ma. Ahuacatitlán, C.P. 62100, Cuernavaca, Morelos, Mexico. Electronic address:

Objective: Depressive symptoms are common comorbidities among breast cancer (BC) patients. Non-pharmacological therapies (NPTs) such as exercise and psychotherapy may reduce depressive symptoms; however, the evidence is inconclusive. The objective of this study is to evaluate if NPTs reduce depressive symptoms among BC patients. Read More

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http://dx.doi.org/10.1016/j.breast.2019.01.006DOI Listing
January 2019

Development and psychometric properties of the assessment questionnaire for the process of the tutorial action plan.

Nurse Educ Today 2019 Feb 13;76:109-117. Epub 2019 Feb 13.

Campus Docent Sant Joan de Déu-Fundació Privada, School of Nursing, University of Barcelona, Barcelona, Spain; Research Group GIES (Grupo de investigación en Enfermería, Educación y Sociedad), Spain; Research Committee of the Campus Docent SJD, Spain; Neonatal and Pediatric Hospital Pedagogy Research Group, Spain.

Background: Internationally, most countries recognize the right of the student to receive assistance from teachers and tutors. The Tutorial Action Plan is a teaching tool that aims to promote academic, personal, and professional development in students. It is important to monitor this process of tutoring to be able to provide appropriate guidance to nursing students throughout their education. Read More

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http://dx.doi.org/10.1016/j.nedt.2019.02.002DOI Listing
February 2019

High CD8 T cell percentage and HCV replication control are common features in HIV-1 controllers and HTLV-2-co-infected patients with a history of injection drug use.

Virus Res 2019 Feb 15. Epub 2019 Feb 15.

Immunovirology Laboratory, Institute of Biomedicine of Seville (IBIS), Virgen del Rocío University Hospital, Avda. Manuel Siurot s/n, 41013 Seville, Spain. Electronic address:

HTLV-2/HIV-1-coinfected patients and HIV-infected patients with natural HIV-1 control show an immune capacity that allows some control of viral infections. These two groups of patients have showed an immune capacity that allows them to have some control over viral infections, very strong control of HIV-1 replication in the case of HIV-1 controllers. The purpose of this retrospective cross-sectional study was to compare viral and immunologic parameters between three cohorts of Caucasian adult HIV-1-infected patients, including HIV-1 controllers (29 patients), HTLV-2/HIV-1 chronic progressors (56 patients), and HIV-1 chronic progressors (101 patients), followed in two different tertiary University Hospitals in Spain. Read More

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http://dx.doi.org/10.1016/j.virusres.2019.02.007DOI Listing
February 2019

[Transition of adolescents with attention deficit/hyperactivity disorder. Implications for treatment of adults].

Medicina (B Aires) 2019 ;79 Suppl 1:72-76

Centro de Salud de Catarroja, Valencia, España.

Attention deficit hyperactivity disorder (ADHD) is a chronic, complex and multifactorial neurodevelopmental disorder associated with high rates of concurrent psychiatric disorders, along with problems and complications on different areas of individual functioning. ADHD is not exclusively a childhood disorder, 40-60% persisting into adulthood with an estimated prevalence of 2.5-5%. Read More

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January 2019

[Attention deficit/hyperactivity disorder. Study habits].

Medicina (B Aires) 2019 ;79 Suppl 1:57-61

Servicio de Neurología Infantil, Hospital Universitario Quirónsalud, Madrid, España E-mail:

Attention deficit / hyperactivity disorder (ADHD) is one of the most prevalent disorders in the child-youth population, with a known impact on learning and school performance. Lack of attention, associated executive dysfunction and comorbid problems -particularly those related to learning and anxiety-, strongly determine this conceptual domain. Affected youths have more problems for taking notes, completion of homework, school programming and less motivation to study. Read More

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January 2019

[Perfectionism and high intellectual capacity].

Medicina (B Aires) 2019 ;79 Suppl 1:33-37

Centro de Investigación en Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, España.

Perfectionism is a psychological construct related o excellence and an optimal manifestation of high intellectual ability (HIA). The main goal of the present work was to compare types and dimensions of perfectionism in students with HIA and an age-gender matched comparison group. We selected 137 participants with diagnosis of HIA and a comparison group of 137 matched by gender and age. Read More

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January 2019

Actual Anti-TNF Trough Levels Relate to Serum IL-10 in Drug-Responding Patients With Crohn's Disease.

Inflamm Bowel Dis 2019 Feb 19. Epub 2019 Feb 19.

CIBERehd, Instituto de Salud Carlos III, Madrid, Spain.

Background: Patients with Crohn's disease (CD) responding to anti-tumor necrosis factor (anti-TNF) show great variability in serum drug levels, even within the therapeutic range. We aimed at exploring the role of inflammatory, genetic, and bacterial variables in relation to anti-TNF through levels in CD patients.

Methods: Consecutive CD patients receiving stable doses of infliximab or adalimumab were included. Read More

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http://dx.doi.org/10.1093/ibd/izz012DOI Listing
February 2019

Why have transgenic rodent models failed to successfully mimic Alzheimer's disease. How can we develop effective drugs without them?

Expert Opin Drug Discov 2019 Feb 18:1-4. Epub 2019 Feb 18.

b CiberNed: Centro de Investigación en Red, enfermedades Neurodegenerativas , Instituto de Salud Carlos III , Madrid , Spain.

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http://dx.doi.org/10.1080/17460441.2019.1581169DOI Listing
February 2019

European Respiratory Society International Congress, Paris, 2018: highlights from the Clinical Assembly.

ERJ Open Res 2019 Feb 11;5(1). Epub 2019 Feb 11.

Dept of Pneumology and Critical Care Medicine, Thoraxklinik, Heidelberg University Hospital, Heidelberg, Germany.

This article contains highlights and a selection of the scientific advances from the European Respiratory Society's Clinical Assembly (Assembly 1 and its five respective groups) that were presented at the 2018 European Respiratory Society International Congress in Paris, France. The most relevant topics from each of the groups will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, and general practice and primary care. The newest research, actual data and highlight sessions will be discussed. Read More

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http://dx.doi.org/10.1183/23120541.00176-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368995PMC
February 2019

Assessing the costs and cost-effectiveness of ICare internet-based interventions (protocol).

Internet Interv 2019 Apr 27;16:12-19. Epub 2018 Feb 27.

TechnischeUniversität Dresden, School of Science, Faculty of Psychology, Chair ofClinical Psychology and E-Mental-Health, 01062 Dresden, Germany.

Background: Mental health problems are common and place a burden on the individual as well as on societal resources. Despite the existence of evidence-based treatments, access to treatment is often prevented or delayed due to insufficient health care resources. Effective internet-based self-help interventions have the potential to reduce the risk for mental health problems, to successfully bridge waiting time for face-to-face treatment and to address inequities in access. Read More

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http://dx.doi.org/10.1016/j.invent.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364355PMC

Physical activity during pregnancy and its influence on delivery time: a randomized clinical trial.

PeerJ 2019 7;7:e6370. Epub 2019 Feb 7.

Hospital Universitario San Cecilio, Granada, Spain.

Introduction: During pregnancy, women often change their lifestyle for fear of harmful effects on the child or themselves. In this respect, many women reduce the amount of physical exercise they take, despite its beneficial effects.

Objective: To determine the duration of labor in pregnant women who completed a program of moderate physical exercise in water and subsequently presented eutocic birth. Read More

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http://dx.doi.org/10.7717/peerj.6370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371916PMC
February 2019

Compression of the middle cerebellar tract by posterior fossa tumors before and after Gamma Knife radiosurgery studied with diffusion tensor imaging.

J Radiosurg SBRT 2019 ;6(1):11-17

Centro Gamma Knife Dominicano, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic.

Purpose: To investigate if clinically asymptomatic compression of the middle cerebellar tract by extracerebral posterior fossa tumors can produce changes in diffusion tensor imaging (DTI) parameters and if these changes return to normal after Gamma Knife radiosurgery (GKRS).

Material And Methods: In 22 patients (12 female, mean age 53.8 years) with posterior fossa tumors (14 schwannomas and 8 meningiomas), the middle cerebellar tract was tracked using DTI data. Read More

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January 2019

Contribution of promoter region gene polymorphism to early-onset prostate cancer risk in Mexican males.

Oncotarget 2019 Jan 22;10(7):738-748. Epub 2019 Jan 22.

Departamento de Toxicología, Cinvestav-IPN, Mexico City, Mexico.

Sexually transmitted infections and its contribution to prostate cancer (PC) development have been relevant in different populations. gene polymorphism (rs10993994) has exhibited an association both with PC as well as the susceptibility to sexually transmitted infections. Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. Read More

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http://dx.doi.org/10.18632/oncotarget.26592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366823PMC
January 2019

DIFFERENCES IN KNEE SENSORIMOTOR CONTROL BY PHYSICAL ACTIVITY LEVEL AND SEX.

Acta Ortop Bras 2019 Jan-Feb;27(1):20-26

Escuela de Kinesiología, Facultad de Ciencias, Universidad Mayor, Chile.

Objective: The aim of this study was to compare the differences in knee sensorimotor control between healthy men and women by measuring the joint position sense (JPS), sensation of muscle tension (steadiness), and onset of muscle activation (OMA).

Methods: Twenty-four healthy women and 27 healthy men were tested. Knee sensorimotor control was assessed using the JPS test with electrogoniometers in 3 different ranges of motion, sensation of muscle tension using the isometric steadiness technique, and OMA against a mechanical perturbation. Read More

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http://dx.doi.org/10.1590/1413-785220192701174327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362696PMC
February 2019

The impact of initial antibiotic treatment failure: real-world insights in patients with complicated, health care-associated intra-abdominal infection.

Infect Drug Resist 2019 31;12:329-343. Epub 2019 Jan 31.

Department of Medicine, Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena - Instituto de Biomedicina de Sevilla (IBiS), Universidad de Sevilla, Seville, Spain,

Purpose: The RECOMMEND study (NCT02364284; D4280R00005) assessed the clinical management patterns and treatment outcomes associated with initial antibiotic therapy (IAT; antibiotics administered ≤48 hours post-initiation of antibiotic therapy) for health care-associated infections across five countries.

Patients And Methods: Data were collected from a retrospective chart review of patients aged ≥18 years with health care-associated complicated intra-abdominal infection (cIAI). Potential risk factors for IAT failure were identified using logistic regression analyses. Read More

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http://dx.doi.org/10.2147/IDR.S184116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362915PMC
January 2019

Analysis of holmium laser enucleation of the prostate in a high volume centre: the impact of concomitant holmium laser cystolitholapaxy.

J Endourol 2019 Feb 16. Epub 2019 Feb 16.

Hospital Universitario 12 de Octubre, Urology, Madrid, Spain ;

Purpose: To assess the influence of holmium laser cystolitholapaxy (HLC) concomitantly with holmium laser prostate enucleation (HoLEP) on patients with benign prostatic hyperplasia (BPH) presenting bladder calculi.

Methods: Retrospective analysis of patients with BPH (with or without concomitant HLC) at three Spanish centers. Intraoperative variables (e. Read More

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http://dx.doi.org/10.1089/end.2019.0019DOI Listing
February 2019

[Skin to skin contact after cesarean delivery.Theme update and actuation proposal].

Rev Esp Salud Publica 2019 Feb 19;93. Epub 2019 Feb 19.

Facultad de Ciencias de la Salud. Universidad de La Laguna. Tenerife. España.

Skin to skin contact (SSC) between mother and child immediately after birth is now considered to be an indicator of good clinical practice as it offers multiple benefits for both: it reduces stress levels of the mother, it facilitates affective bonding, breastfeeding and the newborns adaptation to extra-uterine life. However, in the vast majority of hospitals, mother and child are separated until complete recovery following a caesarean section, which can be several hours. In this article the advantages of SSC after a caesarean section, were analyzed, as well as the main difficulties in order to carry it out, which include maternal or neonatal instability and the reticence of the professionals themselves. Read More

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February 2019

Abnormal Electrocardiographic Findings in the Population Older Than 40 Years. Prevalence and Clinical Significance. Results of the OFRECE Study.

Rev Esp Cardiol (Engl Ed) 2019 Feb 14. Epub 2019 Feb 14.

Servicio de Cardiología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Introduction And Objectives: Abnormal electrocardiographic findings are highly common. The aim of this study was to analyze the prevalence of abnormal electrocardiographic patterns in the general Spanish population aged 40 years or older.

Methods: This subanalysis of the OFRECE study selected a representative sample of the Spanish population aged 40 years or older. Read More

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http://dx.doi.org/10.1016/j.rec.2019.01.001DOI Listing
February 2019

Effectiveness of individual and group multicomponent interventions for smoking cessation in primary care: a quasi-experimental study.

Fam Pract 2019 Feb 17. Epub 2019 Feb 17.

Servicio Extremeño de Salud, Centro de Salud Universitario 'La Paz', Unidad Docente de Medicina Familiar y Comunitaria, Departamento de Ciencias Biomédicas, Universidad de Extremadura, Badajoz, Spain.

Background: The efficacy of smoking cessation interventions can be quite diverse in day-to-day clinical practice.

Objective: To analyse the effectiveness in smoking cessation of multicomponent interventions carried out in groups or individually in primary care practices.

Methods: A quasi-experimental, multicentre study of 12-month follow-up of patients treated in multicomponent smoking cessation interventions was carried out in Urban health care centres in Sevilla, Spain. Read More

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http://dx.doi.org/10.1093/fampra/cmz005DOI Listing
February 2019

Association between high levels of inflammatory markers and cognitive outcomes at 4 years of age: The Rhea mother-child cohort study, Crete, Greece.

Cytokine 2019 Feb 14;117:1-7. Epub 2019 Feb 14.

Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.

There is growing evidence associating inflammatory markers in complex, higher order neurological functions, such as cognition and memory. We examined whether high levels of various inflammatory markers are associated with cognitive outcomes at 4 years of age in a mother-child cohort in Crete, Greece (Rhea study). We included 642 children in this cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.010DOI Listing
February 2019

Spanish validation of the Barcelona TEMPS-A questionnaire in patients with bipolar disorder and general population.

J Affect Disord 2019 Feb 12;249:199-207. Epub 2019 Feb 12.

Bipolar and Depression Disorders Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain. Electronic address:

Background: The Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego (TEMPS-A) is a self-administered questionnaire intended to assess five affective temperaments: depressive, cyclothymic, hyperthymic, irritable and anxious. Our objective was to examine the psychometric properties of the TEMPS-A using a sample comprised by patients with bipolar disorder (BD) and healthy controls (HC) and to determine cut-off scores for each temperament.

Methods: Five hundred and ninety-eight individuals (327 BD and 271 HC) completed the TEMPS-A. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.037DOI Listing
February 2019

Postpartum post-traumatic stress disorder: Associated perinatal factors and quality of life.

J Affect Disord 2019 Feb 10;249:143-150. Epub 2019 Feb 10.

Department of Health Sciencies, University of Jaen, Jaen, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Madrid, Spain.

Background: The relationship between obstetric variables and postpartum post-traumatic stress disorder (PTSD), and its influence on quality of life (QoL), have scarcely been studied.

Objective: Determine the prevalence of PTSD at postpartum weeks 4 and 6, and its relation with perinatal variables and quality of life METHOD: A cross-sectional study with 2990 Spanish puerperal women in Spain. Data were collected on socio-demographic and obstetric variables, and on newborns. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.042DOI Listing
February 2019

Prevalence of overweight and obesity in child population. A study of a cohort in Castile and Leon, Spain.

Endocrinol Diabetes Nutr 2019 Feb 13. Epub 2019 Feb 13.

Dirección General de Salud Pública, Consejería de Sanidad, Junta de Castilla y León, Valladolid, España.

Introduction: Several studies warn that overweight and obesity have become an epidemic with severe consequences in the population's health. The objetive of the present study is to estimate the prevalence of overweight and obesity in Castile and Leon in a sample of children at 6, 11 and 14 years of age, to describe its evolution and its association with life habits and antecedents.

Material And Methods: Observational study, retrospective cohort, performed by the pediatricians of the Health Sentinel Network. Read More

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http://dx.doi.org/10.1016/j.endinu.2018.10.004DOI Listing
February 2019

General and abdominal adiposity and the risk of Parkinson's disease: A prospective cohort study.

Parkinsonism Relat Disord 2019 Feb 8. Epub 2019 Feb 8.

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Germany. Electronic address:

Introduction: Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD.

Methods: In 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.019DOI Listing
February 2019

[Pyogenic psoas abscess as a cause of subacute functional impairment in the elderly patient].

Rev Esp Geriatr Gerontol 2019 Feb 13. Epub 2019 Feb 13.

Servicio de Geriatría, Hospital Central de la Cruz Roja San José y Santa Adela, Madrid, España.

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http://dx.doi.org/10.1016/j.regg.2018.12.006DOI Listing
February 2019

[Prevalence of dementia in the elderly in Latin America: A systematic review].

Rev Esp Geriatr Gerontol 2019 Feb 13. Epub 2019 Feb 13.

Fundación Oftalmológica de Santander, Clínica Carlos Ardila Lulle-FOSCAL, Departamento de Medicina Interna y Geriatria, Bucaramanga, Colombia.

Background And Objective: Dementia is a growing public health problem. It involves the impairment of several cognitive functions, generating mental and physical disability, and therefore greater functional dependence. There is limited epidemiological information which reveals an approximate prevalence in older adults from Latin America. Read More

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http://dx.doi.org/10.1016/j.regg.2018.12.007DOI Listing
February 2019

Patterns of recovery course in early intervention for FIRST episode non-affective psychosis patients: The role of timing.

Schizophr Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain.

Background: Prevention of symptom relapse and promotion of functional recovery are the two main goals of early intervention following a first episode of non-affective psychosis (FEP). The identification of patterns of recovery is important in developing and implementing recovery focused interventions at set time interval.

Method: Patterns of recovery course, in terms of symptomatic and functional remission, were explored at 1 and 3-year follow-up in a sample of 373 consecutive FEP patients. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.032DOI Listing
February 2019

Effect of the pulsation type (alternate or simultaneous) on milk yield and health status of the mammary gland of Murciano-Granadina goats.

J Dairy Sci 2019 Feb 13. Epub 2019 Feb 13.

Dpto. Tecnología Agroalimentaria, Universidad Miguel Hernández (UMH), Ctra. de Beniel km 3.2., 03312 Orihuela (Alicante), Spain. Electronic address:

Recent research into how the pulsation type affects goat milking concluded that alternate pulsation (AP) and simultaneous pulsation (SP) similarly affect the milking efficiency (milking duration and milking fractioning) and teat end condition after milking when both pulsations are employed in short-term experiments. However, the use of SP in high pipeline milking machines led to higher vacuum fluctuations, which, in the long term, may entail a potential risk factor for the mammary gland health status. The aim of this work was to study how AP and SP affect the milk yield, mammary gland health status, and milk composition of goats in the long term, during a complete lactation period, in a high pipeline milking machine. Read More

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http://dx.doi.org/10.3168/jds.2018-15286DOI Listing
February 2019

Detection of the sentinel node using a magnetic tracer in thyroid cancer. A technical pilot study.

Cir Esp 2019 Feb 13. Epub 2019 Feb 13.

Departamento de Cirugía, Pediatría y Obstetricia y Ginecología, Universidad de Murcia, Murcia, España; Servicio de Cirugía General y de Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Servicio Murciano de Salud, Murcia, España; Instituto Murciano de Investigación Bio-Sanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, España.

Introduction: There is no standard procedure for the detection of the sentinel node (SN) in thyroid disease. However, the recent detection of the SN using a paramagnetic tracer is proving to be useful in breast cancer and melanoma. The objective was to assess the utility of super paramagnetic iron oxide tracer for the intraoperative detection of the SN in patients with papillary thyroid cancer without nodal involvement in the preoperative study. Read More

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http://dx.doi.org/10.1016/j.ciresp.2018.12.003DOI Listing
February 2019

Trichoderma longibrachiatum-An unusual pathogen of fungal pericarditis.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology. Hospital Universitario 12 de Octubre. Madrid. Spain.

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http://dx.doi.org/10.1016/j.cmi.2019.02.006DOI Listing
February 2019

Forms of extracellular mitochondria and their impact in health.

Mitochondrion 2019 Feb 13. Epub 2019 Feb 13.

Universidad San Francisco de Quito, Colegio de Ciencias de la Salud - Hospital de los Valles, Escuela de Medicina, Quito 17-12-841, Ecuador; Universidad San Francisco de Quito, Instituto de Investigaciones en Biomedicina, Quito 17-12-841, Ecuador; Mito-Act Research Consortium, Quito, Ecuador; Sistemas Médicos - Universidad San Francisco de Quito, SIME-USFQ, Quito 17-12-841, Ecuador. Electronic address:

Mitochondria play an important role as an intracellular energy plant and signaling organelle. However, mitochondria also exist outside cells where they could mediate cell-to-cell communication, repair and serve as an activator of the immune response. Their effects depend on the mitochondrial state or the form in which it is present, either as a whole functional structure as fragments or only as mitochondrial DNA. Read More

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http://dx.doi.org/10.1016/j.mito.2019.02.002DOI Listing
February 2019

Interventions for the control of Aedes aegypti in Latin America and the Caribbean: Systematic Review and Meta-Analysis.

Trop Med Int Health 2019 Feb 16. Epub 2019 Feb 16.

Instituto de Efectividad Clínica y Sanitaria, Centro de Investigación de Epidemiología y Salud Pública, Argentina.

Objective: To determine the effectiveness and degree of implementation of interventions for the control of Aedes aegypti in Latin America and the Caribbean (LAC) as reported in scientific literature.

Methods: We searched MEDLINE, EMBASE, CENTRAL, SOCINDEX and LILACS, for experimental and observational studies, economic assessments and qualitative experiences carried out in LAC from 2000 to 2016. We assessed incidence and morbimortality of Aedes aegypti-related diseases and entomological indices: Breteau (containers), House, and Pupae per Person. Read More

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http://dx.doi.org/10.1111/tmi.13217DOI Listing
February 2019
1 Read

Prevalence and Correlates of Injecting with Visitors from the United States Among People Who Inject Drugs in Tijuana, Mexico.

J Immigr Minor Health 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, MC-0725, La Jolla, CA, 92093-0725, USA.

Cross-border infectious disease transmission is a concern related to drug tourism from the U.S. to Mexico. Read More

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http://dx.doi.org/10.1007/s10903-019-00868-8DOI Listing
February 2019

Incidence of perineal pain and dyspareunia following spontaneous vaginal birth: a systematic review and meta-analysis.

Int Urogynecol J 2019 Feb 15. Epub 2019 Feb 15.

Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Introduction And Hypothesis: Perineal pain and dyspareunia are experienced by women undergoing a vaginal birth that can have short and longer term physical and psychological morbidities. This review aimed to determine the incidence of perineal pain and dyspareunia following spontaneous vaginal birth (SVB) with intact perineum, first and second-degree perineal trauma or episiotomy.

Methods: Searches of MEDLINE, EMBASE, CINAHL, AMED and MIDIRS (inception - December 2017) were undertaken with selection criteria of any study evaluating the effect of intact perineum, first- or second-degree perineal trauma on perineal pain or dyspareunia in women with SVB. Read More

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http://dx.doi.org/10.1007/s00192-019-03894-0DOI Listing
February 2019

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma.

Cell Mol Life Sci 2019 Feb 15. Epub 2019 Feb 15.

Group of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-Universitat Autònoma de Barcelona (UAB), Passeig Vall d'Hebron 119-129, Collserola Building. Lab 207, 08035, Barcelona, Spain.

Current therapies for most non-infectious diseases are directed at or affect functionality of the human translated genome, barely 2% of all genetic information. By contrast, the therapeutic potential of targeting the transcriptome, ~ 70% of the genome, remains largely unexplored. RNA therapeutics is an emerging field that widens the range of druggable targets and includes elements such as microRNA. Read More

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http://dx.doi.org/10.1007/s00018-019-03041-4DOI Listing
February 2019

Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Medical and Surgical Research Unit, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO removal while potentially reducing the risk of ventilator-induced lung injury.

Objective: To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.

Study Design: Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO). Read More

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http://dx.doi.org/10.1038/s41372-019-0338-5DOI Listing
February 2019

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.

Cell Death Differ 2019 Feb 15. Epub 2019 Feb 15.

Redox Homeostasis Group, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013, Sevilla, Spain.

In the presence of aggregation-prone proteins, the cytosol and endoplasmic reticulum (ER) undergo a dramatic shift in their respective redox status, with the cytosol becoming more oxidized and the ER more reducing. However, whether and how changes in the cellular redox status may affect protein aggregation is unknown. Here, we show that C. Read More

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http://dx.doi.org/10.1038/s41418-018-0270-9DOI Listing
February 2019

Improvements cardiometabolic risk factors in Latin American Amerindians (the Mapuche) with concurrent training.

Scand J Med Sci Sports 2019 Feb 15. Epub 2019 Feb 15.

Education department of La Unión city, Chile.

Our aim was to investigate the effects of 12-weeks of CT (i.e., high-intensity interval and resistance training) in Mapuche adults from Chile and in their peers of European descent. Read More

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http://dx.doi.org/10.1111/sms.13409DOI Listing
February 2019

Long-term Efficacy and Safety of Monotherapy Versus Combination Therapy in Systemic Sclerosis-associated Pulmonary Arterial Hypertension: A Retrospective Cohort Study from the Nationwide Spanish Scleroderma Registry (RESCLE).

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Autoimmune Diseases Unit. Department of Internal Medicine. Bellvitge University Hospital. L'Hospitalet de Llobregat, Barcelona, Spain; Department of Internal Medicine. Corporación Sanitaria Universitaria Parc Taulí. Sabadell, Barcelona, Spain; Unit of Autoimmune Diseases, Department of Internal Medicine. Hospital Universitario Vall d'Hebron. Barcelona, Spain; Unit of Systemic Autoimmune Diseases and Thrombosis. Department of Internal Medicine. Complejo Hospitalario Universitario de Vigo. Vigo, Pontevedra, Spain; Department of Internal Medicine. Hospital Universitario Virgen de las Nieves. Granada, Spain; Department of Internal Medicine. Hospital Universitario y Politécnico La Fe. Valencia, Spain; Department of Internal Medicine. Hospital Universitario Mútua Terrassa. Terrassa, Barcelona, Spain; Unit of Autoimmune Diseases, Department of Internal Medicine. Hospital Clínico Universitario Lozano Blesa. Zaragoza, Spain; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology. Hospital Universitario Clinic. Barcelona, Spain; Department of Internal Medicine. Hospital Universitario Central de Asturias. Oviedo, Asturias, Spain; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine. Hospital Campus de la Salud, Complejo Universitario de Granada. Granada, Spain; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine. Hospital de Cabueñes. Gijón, Asturias, Spain; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Spain; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine. Consorci Hospitalari de Vic. Vic, Barcelona, Spain; Department of Internal Medicine. Hospital Universitario Rey Juan Carlos. Móstoles, Madrid, Spain; Faculty of Medicine and Health Sciences. Universitat Internacional de Catalunya,Barcelona,Spain. Address correspondence to: Melani Pestaña-Fernández MD; Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat Barcelona (Spain). Email:

Objective: Monotherapy is an option as first line therapy for pulmonary arterial hypertension (PAH). However, combination therapy is a beneficial alternative. Our objective was to evaluate efficacy of monotherapy vs. Read More

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http://dx.doi.org/10.3899/jrheum.180595DOI Listing
February 2019
3.187 Impact Factor

Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Medical Oncology, University of Colorado Anschutz Medical Campus.

Purpose: IDO1 induces immune suppression in T cells through L-tryptophan (Trp) depletion and kyneurinine (Kyn) accumulation in the local tumor microenvironment, suppressing effector T-cells and hyperactivating Tregs. Navoximod is an investigational small molecule inhibitor of IDO1. This Phase I study evaluated safety, tolerability, PK and PD of navoximod in combination with atezolizumab, a PD-L1 inhibitor, in patients with advanced cancer. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2740DOI Listing
February 2019

[Food quality in the elderly population in Santiago of Chile].

Rev Esp Geriatr Gerontol 2019 Feb 12. Epub 2019 Feb 12.

Facultad de Ciencias para el Cuidado de la Salud, Universidad San Sebastián, Santiago, Chile. Electronic address:

Introduction: With the increase in the elderly population of Chile, it is very important to evaluate the quality of food of this age group using simple and quick tools.

Objective: To compare the food quality of the elderly, according to gender and age.

Material And Methods: A cross sectional study was conducted on 458 elderly subjects ≥60 years-old of Santiago de Chile. Read More

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http://dx.doi.org/10.1016/j.regg.2019.01.002DOI Listing
February 2019

[Nutritional composition of vending foods of public university and hospital buildings in Asturias].

Aten Primaria 2019 Feb 12. Epub 2019 Feb 12.

Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Campus del Cristo, Oviedo, España.

Objective: To evaluate the nutritional composition of food vending machines (VM) located in university public buildings and hospitals in Asturias.

Design: Descriptive cross-sectional study.

Location: The analysis was made of the contents of VMs located in public buildings, hospitals, and university teaching centres in the Principality of Asturias. Read More

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http://dx.doi.org/10.1016/j.aprim.2018.04.010DOI Listing
February 2019

[Profiles of loneliness and social isolation in urban population].

Aten Primaria 2019 Feb 12. Epub 2019 Feb 12.

CAPSBE, Barcelona, España.

Objective: To assess the prevalence of loneliness and social isolation in a population over 65 cared by a urban primary health team and to identify its main characteristics.

Design: Cross-sectional descriptive study by a telephone survey.

Setting: Basic health area of Barcelona. Read More

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http://dx.doi.org/10.1016/j.aprim.2018.09.012DOI Listing
February 2019

Bacteremia caused by Herbaspirillum huttiense in a newborn.

Enferm Infecc Microbiol Clin 2019 Feb 12. Epub 2019 Feb 12.

Servicio de Microbiología y Parasitología Clínica, Hospital Universitario La Paz, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.eimc.2018.12.011DOI Listing
February 2019

Adherence and Concordance of Influenza and Pertussis Vaccination Coverage in Pregnant Women in Spain.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Unidad Mixta de Investigación para el Análisis de las Desigualdades en Salud y la Mortalidad FISABIO-UA, Departament of Community Health, Preventive Medicine and Public Health, and Science's History, University of Alicante, Carretera de San Vicente del Raspeig s/n, 03690 Alicante, Spain.

: Pregnant women should receive two vaccines during pregnancy due to maternal-foetal complications and risks as well as the influenza and pertussis vaccinations. The goal was to evaluate vaccination coverage against influenza and pertussis in pregnant women, following midwife professional advice during the pregnancy follow-up; : Prospective cohort study of 1017 pregnancies during the vaccination campaign in 2015⁻2016. To estimate the degree of consistency between the coverage declared by mothers and that registered in the Nominal Vaccination Registry (NVR), we used the Cohen's kappa index (k); : 95. Read More

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http://dx.doi.org/10.3390/ijerph16040543DOI Listing
February 2019

Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water.

Environ Toxicol Pharmacol 2019 Feb 7;67:79-86. Epub 2019 Feb 7.

Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Rio-verde, San Luis Potosí, Mexico. Electronic address:

The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.004DOI Listing
February 2019

Rapid assessment of enhanced safety surveillance for influenza vaccine.

Public Health 2019 Feb 12;168:137-141. Epub 2019 Feb 12.

Dirección General de Salud Pública, Conselleria de Sanidad Universal y Salud Pública, Valencia, Spain.

Objectives: The enhanced safety surveillance for seasonal influenza vaccines established by the European Medicines Agency is required each season. Therefore, a registry capable of rapidly detecting and evaluating potential new safety concerns is needed. The aim of the study is to demonstrate the effectiveness of the vaccine information system of the Valencia region to make a rapid assessment of the influenza vaccine safety and describe the safety of the two vaccine types used in the 2017/2018 season. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.013DOI Listing
February 2019