Search Our Scientific Publications & Authors

Lett Appl Microbiol 2020 Jul 6. Epub 2020 Jul 6.

Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center Giza, Giza, Egypt.

Phage therapy is considered an alternative modality in the treatment of different bacterial diseases. However, their therapeutic and preventive roles against infections caused by S.Kentucky and E. Read More

EFSA J 2019 Dec 11;17(12):e05926. Epub 2019 Dec 11.

This report of the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring activities carried out in 2018 in 36 European countries (28 Member States (MS) and 8 non-MS). The first and second most commonly reported zoonoses in humans were campylobacteriosis and salmonellosis, respectively. The European Union (EU) trend for confirmed human cases of these two diseases was stable during 2014-2018. Read More

BMC Biol 2020 Jul 3;18(1):83. Epub 2020 Jul 3.

Department of Microbiology and Immunology, University of Louisville, Louisville, KY, 40202, USA.

Background: Experimental reproducibility in mouse models is impacted by both genetics and environment. The generation of reproducible data is critical for the biomedical enterprise and has become a major concern for the scientific community and funding agencies alike. Among the factors that impact reproducibility in experimental mouse models is the variable composition of the microbiota in mice supplied by different commercial vendors. Read More

Vaccine 2020 Jun 29. Epub 2020 Jun 29.

National Institute of Animal Health, NARO, 3-1-5, Kannondai, Tsukuba, Ibaraki 305-0856, Japan. Electronic address:

Anti-O-antigen antibodies, such as anti-O4 antigen IgG, induce protective immunity against Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. S. Read More

PLoS Negl Trop Dis 2020 Jul 2;14(7):e0008377. Epub 2020 Jul 2.

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Non-typhoidal Salmonella (NTS) serotypes Typhimurium and Enteritidis are a major cause of bloodstream infections in children in sub-Saharan Africa but their reservoir is unknown. We compared pairs of NTS blood and stool isolates (with the same NTS serotype recovered in the same patient) for genetic similarity.

Methods: Between November 2013 and April 2017, hospital-admitted children (29 days to 14 years) with culture-confirmed NTS bloodstream infections were enrolled in a cross-sectional study at Kisantu Hospital, DR Congo. Read More

MMWR Morb Mortal Wkly Rep 2020 Jul 3;69(26):815-819. Epub 2020 Jul 3.

In May 2019, the New York City Department of Health and Mental Hygiene (NYCDOHMH) detected an unusual cluster of five salmonellosis patients via automated spatiotemporal analysis of notifiable diseases using free SaTScan software (1). Within 1 day of cluster detection, graduate student interviewers determined that three of the patients had eaten prepared food from the same grocery store (establishment A) located inside the cluster area. NYCDOHMH initiated an investigation to identify additional cases, establish the cause, and provide control recommendations. Read More

World J Microbiol Biotechnol 2020 Jul 2;36(7):103. Epub 2020 Jul 2.

Division of Biochemistry, School of Medical Sciences, University of Phayao, 19 Moo 2, Tambon Maeka, Amphur Muang, Phayao, 56000, Thailand.

Food poisoning from consumption of food contaminated with non-typhoidal Salmonella spp. is a global problem. A modified high resolution DNA melting curve analysis (m-HRMa) was introduced to provide effective discrimination among closely related HRM curves of amplicons generated from selected Salmonella genome sequences enabled Salmonella spp. Read More

J Antimicrob Chemother 2020 Jul 1. Epub 2020 Jul 1.

Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.

Objectives: To determine the immune cell populations associated with Salmonella enterica serovar Typhimurium before and after ciprofloxacin treatment using a murine model of systemic infection. The effect of depletion of immune cells associating with Salmonella on treatment outcome was also determined.

Methods: We infected mice with a Salmonella enterica serovar Typhimurium strain expressing GFP and used multicolour flow cytometry to identify splenic immune cell populations associating with GFP-positive Salmonella before and after treatment with ciprofloxacin. Read More

PLoS One 2020 1;15(7):e0235291. Epub 2020 Jul 1.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

Nontyphoidal Salmonella enterica (NTS) causes a substantial health burden to human populations in Canada and worldwide. Exposure sources and demographic factors vary by location and can therefore have a major impact on salmonellosis clustering. We evaluated major NTS serotypes: S. Read More

Virus Evol 2020 Jan 22;6(1):veaa030. Epub 2020 Jun 22.

Department of Biology, Loyola University Chicago, 1032 W Sheridan Rd, Chicago, IL 60660, USA.

Filamentous phages establish chronic infections in their bacterial hosts, and new phages are secreted by infected bacteria for multiple generations, typically without causing host death. Often, these viruses integrate in their host's genome by co-opting the host's XerCD recombinase system. In several cases, these viruses also encode genes that increase bacterial virulence in plants and animals. Read More

Diagnostics (Basel) 2020 Jun 28;10(7). Epub 2020 Jun 28.

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.

Paratyphoid fever is caused by the bacterium serovar Paratyphi (A, B and C), and contributes significantly to global disease burden. One of the major challenges in the diagnosis of paratyphoid fever is the lack of a proper gold standard. Given the absence of a licensed vaccine against Paratyphi, this diagnostic gap leads to inappropriate antibiotics use, thus, enhancing antimicrobial resistance. Read More

PLoS Negl Trop Dis 2020 Jun 30;14(6):e0008375. Epub 2020 Jun 30.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

Background: Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low- and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing etiology of AGE and associated risk factors in Latin America, including Colombia, is essential to understand the epidemiology of these infections. The primary objectives of this study were to describe etiology of moderate to severe AGE in children less than 5 years of age from Bucaramanga, Colombia, a middle-income country in Latin American, and to identify the presence of emerging E. Read More

J Clin Immunol 2020 Jun 30. Epub 2020 Jun 30.

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare congenital condition characterized by a selective predisposition to infections caused by weakly virulent mycobacteria and other types of intra-macrophagic pathogens. The 16 genes associated with MSMD display a considerable level of allelic heterogeneity, accounting for 31 distinct disorders with variable clinical presentations and prognosis. Most of MSMD deficiencies are isolated, referred to as selective susceptibility to mycobacterial diseases. Read More

Infect Immun 2020 Jun 29. Epub 2020 Jun 29.

GSK Vaccines institute for Global Health, Via Fiorentina 1, 53100, Siena (Italy).

causes grave systemic infections in humans and other animals and provides a paradigm for other diseases where the bacteria have both intracellular and extracellular lifestyles.New generations of vaccines rely on the essential contribution of the antibody responses for their protection. The quality, antigen specificity and functions associated with antibody responses to this pathogen have been elusive for a long time. Read More

Int J Food Microbiol 2020 Feb 14;330:108559. Epub 2020 Feb 14.

Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, Guelph, ON, Canada. Electronic address:

Salmonella Heidelberg resistant to ceftiofur (a third-generation cephalosporin antimicrobial agent) in broiler chicken products pose a risk to public health in Canada. The objective of this study was to assess the extent of that risk and to evaluate the effect of intervention measures along the agri-food chain. A stochastic farm-to-fork quantitative microbial risk assessment model was developed following the Codex Alimentarius Guidelines for Risk Analysis of Foodborne Antimicrobial Resistance. Read More

Microb Pathog 2020 Jun 24;147:104352. Epub 2020 Jun 24.

Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai, 625021, Tamilnadu, India. Electronic address:

Salmonellosis continues to remain a health problem as the causative organism Salmonella spp. developed resistance to many of the antibiotics. As per World Health Organization (WHO), it is estimated that enteric fever, accounts for almost 16 million cases annually and over 600,000 deaths worldwide. Read More

J Immunol 2020 Jun 26. Epub 2020 Jun 26.

Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom;

Clearance of intracellular infections caused by Typhimurium (STm) requires IFN-γ and the Th1-associated transcription factor T-bet. Nevertheless, whereas IFN-γ mice succumb rapidly to STm infections, T-bet mice do not. In this study, we assess the anatomy of immune responses and the relationship with bacterial localization in the spleens and livers of STm-infected IFN-γ and T-bet mice. Read More

Appl Environ Microbiol 2020 Jun 26. Epub 2020 Jun 26.

Department of Civil and Environmental Engineering, University of Hawaii at Manoa, Honolulu, HI 96822

Clinical surveillance of enteric pathogens like is integral to track outbreaks and endemic disease trends. However, clinic-centered disease monitoring biases toward detection of severe cases and underestimates the incidence of self-limiting gastroenteritis and asymptomatic strains. Monitoring pathogen loads and diversity in municipal wastewater (MW) can provide insight into asymptomatic or subclinical infections which are not reflected in clinical cases. Read More

BMC Pediatr 2020 Jun 26;20(1):309. Epub 2020 Jun 26.

Department of Gastroenterology, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, 210008, Jiangsu Province, China.

Background: Persistent and chronic diarrhea is difficult to treat, and infection is still the main cause. In this study, we investigate the application value of xTAG gastrointestinal pathogen panel (xTAG GPP) multiplex PCR in the early diagnosis of persistent and chronic diarrhea in children and to understand the epidemiology of intestinal diarrhea pathogens.

Methods: One hundred ninety-nine specimens were collected from Nanjing Children's Hospital Affiliated to Nanjing Medical University (Nanjing, China). Read More

Microb Genom 2020 Jun 26. Epub 2020 Jun 26.

Zhejiang Provincial Laboratory of Preventive Veterinary Medicine, Hangzhou 310058, PR China.

is composed of a wide variety of serovars, causing human self-limited gastrointestinal illnesses or invasive infections. Invasive non-typhoidal (iNTS) is well documented, with high mortality for children and immunocompromised adults in sub-Saharan Africa and has recently been reported in Southeast Asia. However, iNTS in China remains unknown. Read More

J Vet Res 2020 Jun 12;64(2):263-268. Epub 2020 May 12.

Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225009, China.

Introduction: Salmonellosis is a zoonotic disease, and spp. can sometimes be found in dogs and cats, posing a risk to human health. In this study, the prevalence and antimicrobial susceptibility of faecal were investigated in pet dogs and cats in Xuzhou, Jiangsu Province, China. Read More

PeerJ 2020 16;8:e9113. Epub 2020 Jun 16.

Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, Thailand.

Background: Nontyphoidal spp. constitute a major bacterial cause of food poisoning. Each serotype causes distinct virulence to humans. Read More

BMJ Open Gastroenterol 2020 Jun;7(1)

Information Team, West Suffolk NHS Foundation Trust, Bury St Edmunds, UK.

Objective: To estimate the number of deaths from foodborne disease in the UK from 11 key pathogens.

Design: Four different models were developed using data from a range of sources. These included enhanced surveillance, outbreaks, death certificates and hospital episode statistics data. Read More

J Clin Microbiol 2020 Jun 24. Epub 2020 Jun 24.

Sydney Medical School, The University of Sydney, NSW, AUSTRALIA.

is a highly diverse genus consisting of over 2600 serovars responsible for high-burden food- and water-borne gastroenteritis worldwide. Sensitivity and specificity of PCR-based culture-independent diagnostic testing (CIDT) systems for , which depend on a highly conserved gene target, can be affected by single nucleotide polymorphisms (SNPs), indels and genomic rearrangements within primer and probe sequences. This report demonstrates the value of prospectively collected genomic data for verifying CIDT targets. Read More

J Food Prot 2020 Jul;83(7):1234-1240

Faculty of Agriculture, Kindai University, 3327-204, Nakamachi, Nara-shi, Nara 631-8505, Japan (ORCID: https://orcid.org/0000-0002-9651-9856 [M.M.]).

Abstract: Hygiene management of domestic refrigerators is an important aspect of food poisoning prevention. The aim of the present study was to confirm the relationship between microbial contamination and hygiene management by measuring microbial levels and investigating temperature and cleaning frequency and method of domestic refrigerators in Japan. We analyzed three internal sections (the egg compartment, bottom shelf, and vegetable drawer) of 100 domestic refrigerators in Japan. Read More

BMC Infect Dis 2020 Jun 22;20(1):436. Epub 2020 Jun 22.

Division of Otolaryngology Head and Neck Surgery, Department of Surgery, Dalhousie University, 5850 University Avenue, Halifax, NS, B3K 6R8, Canada.

Background: Thyroid gland infections are rare. Their incidence is estimated to be less than 1% in immunocompromised hosts. Most common pathogens isolated are Gram positive aerobic cocci. Read More

Sci Total Environ 2020 Aug 20;728:138808. Epub 2020 Apr 20.

Faculty of Health Sciences, Simon Fraser University, 8888 University Drive Blusson Hall 11518, Burnaby, BC V5A 1S6, Canada. Electronic address:

Background: Food- and water-borne pathogens exhibit spatial heterogeneity, but attribution to specific environmental processes is lacking while anthropogenic climate change alters these processes. The goal of this study was to investigate ecology, land-use and health associations of these pathogens and to make future disease projections.

Methods: The rates of five acute gastrointestinal illnesses (AGIs) (campylobacteriosis, Verotoxin- producing Escherichia coli, salmonellosis, giardiasis and cryptosporidiosis) from 2000 to 2013 in British Columbia, Canada, were calculated across three environmental variables: ecological zone, land use, and aquifer type. Read More

Int J Infect Dis 2020 Jun 19. Epub 2020 Jun 19.

Cambodia Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom. Electronic address:

Objectives: Enteric fever remains an important diagnostic and treatment challenge in febrile children living in the tropics. In the context of a national Salmonella enterica serovar Paratyphi A outbreak, this retrospective study objective was to compare features of S. Typhi and S. Read More

Immunol Cell Biol 2020 Jun 22. Epub 2020 Jun 22.

Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.

Mucosal Associated Invariant T (MAIT) cells are key players in the immune response against microbial infection. The MAIT T cell receptor (TCR) recognizes a diverse array of microbial ligands and recent reports have highlighted the variability in the MAIT TCR that could further contribute to discrimination of ligand. The MAIT TCR CDR3β sequence displays a high level of diversity across individuals and clonotype usage appears to be dependent on antigenic exposure. Read More

Biochemistry 2020 Jun 30. Epub 2020 Jun 30.

Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322, United States.

is the causative agent of bacillary dysentery and is responsible for an estimated 165 million infections and 600,000 deaths annually. Like many Gram-negative pathogens, relies on a type three secretion system (T3SS) to initiate and sustain infection by directly injecting effector proteins into host cells. Protein secretion through the needle-like injectisome and overall virulence rely on the T3SS ATPase Spa47, making it a likely means for T3SS regulation and an attractive target for therapeutic small molecule inhibitors. Read More

Case Rep Vet Med 2020 4;2020:7062408. Epub 2020 Jun 4.

Department of Clinical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA.

A 17-year-old Quarter Horse mare was evaluated for colic of 24-hour duration. Clinical signs and diagnostic evaluation were consistent with duodenitis-proximal jejunitis. The horse's clinical condition deteriorated despite medical treatment and was euthanized. Read More

Genomics 2020 Jun 18. Epub 2020 Jun 18.

Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran. Electronic address:

Salmonella enterica serovar Typhi (S. Typhi) is an essential enteric fever causing bacterium worldwide. Due to the emergence of multidrug-resistant strains, urgently attention is needed to prevent the global spread of them. Read More

J Infect 2020 Jun 16. Epub 2020 Jun 16.

Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung 84001, Taiwan. Electronic address:

Objectives: To explore the association between nontyphoidal salmonellosis (NTS) and the risk of acute ischemic stroke (IS) by using a nationwide, population-based study.

Methods: A retrospective cohort study using claim data from Taiwan's National Health Insurance Research Database (NHIRD), patients aged 18 years and older with histories of NTS (N = 1618) were included from January 1, 2000-December 31, 2012, and the non-NTS group (N = 6472) without NTS were matched by propensity score. The follow-up period was defined as the time from the initial diagnosis of NTS to the date of development of IS, death or 31 December, 2013. Read More

BMC Vet Res 2020 Jun 19;16(1):205. Epub 2020 Jun 19.

Department of Microbiology, Veterinary Faculty, Firat University, 23100, Elazig, Turkey.

Background: The aim of this study was to obtain quantitative data about the frequency, genotypic characterization and antibiotic resistance profiling of Salmonella agents in chicken flocks located in eastern Turkey.

Results: Feces samples representing at least 20% of the flock area were collected via sock swabs from commercial poultry flocks in the study region in addition to internal organs (liver, spleen, intestine) collected at necropsy of suspected chickens belonging to small family enterprises. The samples were analyzed by conventional bacteriological methods (ISO 6579:2002/A1:2007) for isolation, and genus specific (invA) PCR for the identification of Salmonella spp. Read More

PLoS One 2020 19;15(6):e0234399. Epub 2020 Jun 19.

Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City, Guatemala.

Background: Dengue, chikungunya, and Zika viruses are increasingly important public health problems. Burning vegetation, leaves, and other plant products have been shown to be effective mosquito repellents for their vector, Aedes spp., but there has been scant research on whether firewood cooking smoke in households influences mosquito populations or mosquito-borne diseases. Read More

Zoonoses Public Health 2020 Jun 19. Epub 2020 Jun 19.

Department of Population Medicine, University of Guelph, Ontario Veterinary College, Guelph, Canada.

Purpose: Salmonellosis is one of several reportable diseases in Ontario (ON). Two or more cases of the same serotype that are linked to a common exposure or related to one another in time and/or space are considered a potential outbreak. While laboratory data can help to determine the molecular relatedness of cases, results may take up to several weeks. Read More

Probiotics Antimicrob Proteins 2020 Jun 17. Epub 2020 Jun 17.

Department of Microbiology, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.

Pathogens develop resistance to antibiotics at a rate much faster than the discovery of new antimicrobial compounds. Reports of multidrug-resistant bacteria isolated from broilers, and the possibility that these strains may spread diseases amongst humans, prompted many European countries to ban the inclusion of antibiotics in feed. Probiotics added to broiler feed controlled a number of bacterial infections. Read More

J Food Prot 2020 Jun 18. Epub 2020 Jun 18.

University of Florida Emerging Pathogens Institute, Institute for Sustainable Food Systems Animal Sciences Department 2055 Mowry Road UNITED STATES Gainesville FL 32611.

The Florida Complaint and Outbreak Reporting System (FL-CORS) database is used by the Florida Department of Health's Food and Waterborne Disease Program (FWDP) as one of the tools to detect foodborne disease outbreaks. We present a descriptive and spatial network analysis of the FL-CORS data collected during 2015-2018. We also quantified foodborne disease outbreaks (FBO) which were investigated and confirmed due to a filed complaint and the etiological agents involved in these outbreaks. Read More

Cell Rep 2020 06;31(11):107772

Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. Electronic address:

ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. The signals that lead to the production of extracellular ISG15 and the relationship between its two core functions remain unclear. We show that both epithelial cells and lymphocytes can secrete ISG15, which then signals in either an autocrine or paracrine manner to LFA-1-expressing cells. Read More

BMC Infect Dis 2020 Jun 17;20(1):422. Epub 2020 Jun 17.

Centre for Microbiology Research, Kenya Medical Research Institute, Off Mbagathi Road, PO Box 54840-00200, Nairobi, Kenya.

Background: In Kenya, typhoid fever and invasive non-typhoidal salmonellosis present a huge burden of disease, especially in poor-resource settings where clean water supply and sanitation conditions are inadequate. The epidemiology of both diseases is poorly understood in terms of severity and risk factors. The aim of the study was to determine the disease burden and spatial distribution of salmonellosis, as well as socioeconomic and environmental risk factors for these infections, in a large informal settlement near the city of Nairobi, from 2013 to 2017. Read More

Gut Microbes 2020 Nov 18;11(6):1486-1517. Epub 2020 Jun 18.

University of Illinois at Urbana-Champaign , Department of Pathobiology, Urbana, Illinois, USA.

Enteric viral and bacterial infections continue to be a leading cause of mortality and morbidity in young children in low-income and middle-income countries, the elderly, and immunocompromised individuals. Vaccines are considered an effective and practical preventive approach against the predominantly fecal-to-oral transmitted gastroenteritis particularly in the resource-limited countries or regions where implementation of sanitation systems and supply of safe drinking water are not quickly achievable. While vaccines are available for a few enteric pathogens including rotavirus and cholera, there are no vaccines licensed for many other enteric viral and bacterial pathogens. Read More

MethodsX 2020 29;7:100936. Epub 2020 May 29.

Department of Immunology, IML and IdSSC, Hospital Clínico San Carlos, Madrid, Spain.

Assessment of specific antibody (Ab) production to polysaccharide antigens is clinically relevant, identifying patients at risk for infection by encapsulated bacteria and thus enabling a more rigorous selection of patients that can benefit of immunoglobulin replacement therapy. Classically, the gold-standard test is the measurement of antibody production to pure polysaccharide pneumococcal (PPV) immunization. Several factors, including introduction of conjugate vaccination schedule, serotyping analysis, high baseline Ab levels, have hindered the evaluation of polysaccharide antigens. Read More

Rozhl Chir 2020 ;99(5):232-235

Introduction: Although gastroenteritis is considered to be a non-surgical disease, rare complications necessitating surgical intervention may occur.

Case Report: We present a patient who underwent acute small bowel resection due to an abdominal abscess, which developed in association with Salmonella enteritis. Read More

Int J Mol Sci 2020 Jun 13;21(12). Epub 2020 Jun 13.

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn, Poland.

Endometrial infections at a young age can lead to fertility issues in adulthood. Bacterial endotoxins, such as lipopolysaccharide (LPS), can participate in long-term molecular changes even at low concentrations. Lipopolysaccharide plays a crucial role in the progression of septic shock, inflammation and auto-immune diseases. Read More

Prev Vet Med 2020 Jan 9:104884. Epub 2020 Jan 9.

Faculty of Veterinary Medicine, Department of Reproduction, Obstetrics and Herd Health, Ghent University, Merelbeke, Belgium.

Subclinical Salmonella Typhimurium infections occur frequently in pigs and constitute a major risk for human salmonellosis. With the currently available control measures, Salmonella Typhimurium infections in pigs remain difficult to control. Vaccination has been proposed to be an effective tool to control infections at farm level. Read More

Arch Microbiol 2020 Jun 13. Epub 2020 Jun 13.

Dalian Customs of the People's Republic of China, Dalian, 116000, China.

Salmonella developed drug-resistance under durative antibiotic pressures pressure. The widespread prevalence of Salmonella has been associated with not only drug-resistance but also pathogenicity. Outer membrane porin proteins (OMPs) are critical for the drug resistance of bacteria. Read More

Gene Ther 2020 Jun 12. Epub 2020 Jun 12.

Molecular and Cellular Immunology Unit, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.

Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder characterised by recurrent and often life-threatening infections and hyperinflammation. It is caused by defects of the phagocytic NADPH oxidase, a multicomponent enzyme system responsible for effective pathogen killing. A phase I/II clinical trial of lentiviral gene therapy is underway for the most common form of CGD, X-linked, caused by mutations in the gp91 subunit of the NADPH oxidase. Read More

Microbiol Resour Announc 2020 Jun 11;9(24). Epub 2020 Jun 11.

Division of Enteric Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.

with antigenic formula 4,[5],12:i:- is a monophasic variant of serovar Typhimurium that has emerged globally as a human pathogen over the last 3 decades. We describe the closed genomes and plasmids from six 4,[5],12:i:- isolates recovered from stool samples obtained during investigation of human food poisoning cases reported to PulseNet Canada that are suitable for use as reference strains. Read More

Cell Host Microbe 2020 06;27(6):851-853

Department of Microbiology, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

In this issue of Cell Host and Microbe, Lee et al. define the glycan binding specificity of a variant of typhoid toxin produced by a non-typhoidal Salmonellae serotype. The authors elegantly demonstrate that tissue and host specificity of the toxin are related to specific glycan binding characteristics of the toxin. Read More

mSphere 2020 Jun 10;5(3). Epub 2020 Jun 10.

Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada

comprises more than 2,600 serovars. Very few environmental and uncommon serovars have been characterized for their potential role in virulence and human infections. A complementary and systematic high-throughput analysis of virulence was used to elucidate the association between genetic and phenotypic variations across isolates. Read More