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BMJ Case Rep 2021 Jun 23;14(6). Epub 2021 Jun 23.

Infectious Diseases, Northern Care Alliance NHS Group, Manchester, UK.

Infective endocarditis is associated with morbidity and mortality even when appropriately treated. It can be more complicated to treat when prosthetic material is present, often necessitating surgical revision as well as antimicrobial therapy. Endocarditis caused by gram-negative bacilli is a rare occurrence, with some literature and expert opinion suggesting superior outcomes with combined surgery and antibiotics when a prosthetic valve is involved. Read More

J Korean Med Sci 2021 Jun 21;36(24):e180. Epub 2021 Jun 21.

Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea.

Background: After the global epidemic of coronavirus disease 2019 (COVID-19), lifestyle changes to curb the spread of COVID-19 (e.g., wearing a mask, hand washing, and social distancing) have also affected the outbreak of other infectious diseases. Read More

Appl Microbiol Biotechnol 2021 Jun 22. Epub 2021 Jun 22.

College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, Yangzhou, 225009, China.

Salmonella Enteritidis (SE) causes both horizontal and vertical transmission of diseases in poultry industry and is also one of the main causes of human food poisoning. Sequence analysis of the sef operon of poultry-derived Salmonella serotypes showed the presence of an entire sef operon in SE, whereas only sef pseudogenes were found in Salmonella Gallinarum and Salmonella Pullorum. Subsequently, the sef operon of SE was cloned into the pBR322 plasmid and expressed in a modified Escherichia coli strain SE5000. Read More

mBio 2021 Jun 22:e0109321. Epub 2021 Jun 22.

Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

Antimicrobial resistance (AMR) is a pressing global health crisis, which has been fueled by the sustained use of certain classes of antimicrobials, including fluoroquinolones. While the genetic mutations responsible for decreased fluoroquinolone (ciprofloxacin) susceptibility are known, the implications of ciprofloxacin exposure on bacterial growth, survival, and interactions with host cells are not well described. Aiming to understand the influence of inhibitory concentrations of ciprofloxacin we subjected three clinical isolates of Salmonella enterica serovar Typhimurium to differing concentrations of ciprofloxacin, dependent on their MICs, and assessed the impact on bacterial growth, morphology, and transcription. Read More

Zoonoses Public Health 2021 Jun 20. Epub 2021 Jun 20.

Tokyo University of Agriculture and Technology, Tokyo, Japan.

A total of 1,318 wild geckos were collected in Cambodia, Thailand and Vietnam (Hue and the Mekong Delta) from 2012 to 2015 to determine the prevalence of Salmonella Weltevreden. Those geckos belong to three species: common house gecko (Hemidactylus frenatus), flat-tailed house gecko (Hemidactylus platyurus) and four-clawed gecko (Gehyra mutilata). Of 1,318 gecko samples, 293 (22. Read More

Pediatr Res 2021 Jun 19. Epub 2021 Jun 19.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Introduction: Although non-typhoidal Salmonella (NTS) infection usually causes self-limited enterocolitis, several risk factors have been found to predispose individuals to more severe NTS infections. However, few studies have discussed the association between NTS infection and pediatric thalassemia populations.

Material And Methods: A nationwide population-based retrospective cohort study was conducted using medical records of the selected children from the Taiwan National Health Insurance Research Database. Read More

Travel Med Infect Dis 2021 Jun 16:102105. Epub 2021 Jun 16.

Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; IHU-Méditerranée Infection, Marseille, France. Electronic address:

Background: The aetiologies of fever are poorly understood in sub-Saharan Africa. We aimed to assess the burden of malaria and bacteria in Côte d'Ivoire.

Methods: Blood samples from 438 febrile and 346 afebrile people were screened using molecular tools. Read More

Mol Nutr Food Res 2021 Jun 19:e2100209. Epub 2021 Jun 19.

State Key Laboratory of Animal Nutrition, Department of Animal Nutrition & Feed Science, College of Animal Science & Technology, China Agricultural University, Haidian District, Beijing, 100193, China.

Scope: Salmonella is the main food-borne pathogen, which can infect intestinal epithelial cells and cause colitis. Genistein had a variety of biological activities that alleviated colitis induced by sodium dextran sulfate in a variety of ways, but its protective effects on colitis caused by pathogenic bacteria are still unknown.

Methods And Results: This study explored the protective effect of genistein in reducing colitis caused by Salmonella infection. Read More

PLoS Pathog 2021 Jun 18;17(6):e1009319. Epub 2021 Jun 18.

Abt. Mikrobiologie, Universität Osnabrück, Osnabrück, Germany.

Salmonella enterica is a common foodborne, facultative intracellular enteropathogen. Human-restricted typhoidal S. enterica serovars Typhi (STY) or Paratyphi A (SPA) cause severe typhoid or paratyphoid fever, while many S. Read More

Commun Dis Intell (2018) 2021 Jun 15;45. Epub 2021 Jun 15.

Australian Government Department of Health.

Abstract: This report summarises the incidence of diseases potentially transmitted by food in Australia, and details outbreaks associated with food that occurred during 2013-2015. OzFoodNet sites reported an increasing number of notifications of 12 diseases or conditions vthat may be transmitted by food (botulism; campylobacteriosis; cholera; hepatitis A; hepatitis E; haemolytic uraemic syndrome (HUS); listeriosis; Salmonella Paratyphi (paratyphoid fever) infection; salmonellosis; shigellosis; Shiga toxin-producing Escherichia coli (STEC) infection; and Salmonella Typhi (typhoid fever) infection), with a total of 28,676 notifications received in 2013; 37,958 in 2014; and 41,226 in 2015. The most commonly-notified conditions were campylobacteriosis (a mean of 19,061 notifications per year over 2013-2015) and salmonellosis (a mean of 15,336 notifications per year over 2013-2015). Read More

Res Vet Sci 2021 Jun 10;138:125-136. Epub 2021 Jun 10.

Department of Pathobiology and Veterinary Science, College of Agriculture, Health and Natural Resources, University of Connecticut, Storrs, CT, USA; Connecticut Veterinary Medical Diagnostic Laboratory, Department of Pathobiology and Veterinary Science, College of Agriculture, Health and Natural Resources, University of Connecticut, Storrs, CT, USA. Electronic address:

Salmonella enterica subspecies diarizonae serovar 61:(k):1, 5, (7) (sheep associated S. diarizonae, SASd) is the most common Salmonella serotype identified in sheep flocks. Despite the involvement with animal and human infections, there is limited information regarding virulence profiles of SASds and their antibiotic resistance gene complement, particularly for those circulating in the U. Read More

PLoS One 2021 17;16(6):e0253312. Epub 2021 Jun 17.

Centre National de Référence des Escherichia coli, Shigella et Salmonella, Unité des Bactéries Pathogènes Entériques, Institut Pasteur, Paris, France.

Background: Gastrointestinal infections are a global public health problem. In Burkina Faso, West Africa, exposure to Salmonella through the consumption of unhygienic street food represents a major risk of infection requiring detailed evaluation.

Methods: Between June 2017 and July 2018, we sampled 201 street food stalls, in 11 geographic sectors of Ouagadougou, Burkina Faso. Read More

Prague Med Rep 2021 ;122(2):96-105

Department of Infectious Diseases, First Faculty of Medicine, Charles University and Military University Hospital Prague, Prague, Czech Republic.

In our study we present an overview of the use of Oxford Nanopore Technologies (ONT) sequencing technology on the background of Enteric fever. Unlike traditional methods (e.g. Read More

Matern Child Nutr 2021 Jun 17:e13215. Epub 2021 Jun 17.

Unité de Pathogénie Microbienne Moléculaire, INSERM U1202, Department of Cell Biology and Infection, Institut Pasteur, Paris, France.

In the MITICA (Mother-to-Infant TransmIssion of microbiota in Central-Africa) study, 48 mothers and their 50 infants were followed from delivery to 6 months between December 2017 and June 2019 in Bangui (Central-African Republic). Blood tests and stool analyses were performed in mothers at delivery, and their offspring at birth, 11 weeks and 25 weeks. Stool cultures were performed in specific growth media for Salmonella, Shigella, E. Read More

Trop Med Health 2021 Jun 15;49(1):49. Epub 2021 Jun 15.

Department of Plant Sciences, Microbiology & Biotechnology, Makerere University, P.O Box 7062, Kampala, Uganda.

Background: Rural populations in Uganda rely heavily on medicinal plants for the treatment of bacterial skin infections. However, the efficacy of these medicinal plants for their pharmacological action is not known. The study aimed at evaluating the antibacterial, antioxidant, and sun protection potential of Spermacoce princeae, Psorospermum febrifugum, Plectranthus caespitosus, and Erlangea tomentosa extracts. Read More

J Nanobiotechnology 2021 Jun 14;19(1):183. Epub 2021 Jun 14.

Laboratory of Molecular Nutrition and Immunity, The Institute of Animal Nutrition, Northeast Agricultural University, Harbin, People's Republic of China.

Background: Acid-tolerant enteric pathogens can evade small intestinal acid barriers, colonize and infect the intestinal tract. However, broad-spectrum antibiotics are not the best therapeutic strategy because of the disruption of intestinal flora caused by its indiscriminate antimicrobial activity against beneficial and harmful bacteria. So that is what inspired us to combine pH regulation with nanotechnology to develop a pH-triggered site-targeted antimicrobial peptide with entrapping function. Read More

mBio 2021 Jun 15:e0027621. Epub 2021 Jun 15.

Université de Paris, Paris, France.

Antibiotic-resistant Staphylococcus aureus strains constitute a major public health concern worldwide and are responsible for both health care- and community-associated infections. Here, we establish a robust and easy-to-implement model of oral S. aureus infection using Drosophila melanogaster larvae that allowed us to follow the fate of S. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 21;261:119986. Epub 2021 May 21.

Institute of Environmental, Chemical and Pharmaceutical Sciences, Department of Biology, Federal University of Sao Paulo, Diadema, Sao Paulo, Brazil.

Contaminated poultry products as eggs and meat are the primary vehicles of Salmonella infection. Conventional methods for microorganisms detections involve multiple steps, and despite its accuracy, these assays are time-consuming. Biosensing methods have shown great potential for the rapid detection of foodborne pathogens. Read More

Microb Pathog 2021 Jun 12;158:105010. Epub 2021 Jun 12.

Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil. Electronic address:

Amebiasis is the most severe protozoan infection affecting the human intestine, and the second leading cause of death among parasitic diseases. The mechanisms of amoebic virulence factors acquisition are poorly understood, and there are few studies showing the interaction between Entamoeba dispar and bacteria. Salmonella enterica subsp. Read More

J Glob Antimicrob Resist 2021 Jun 9. Epub 2021 Jun 9.

Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor Darul Ehsan, Malaysia; Department of Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, 840212, Sultan Abubakar Road, City Campus Complex, Sokoto State, Nigeria.

Objective: The emergence and dissemination of resistance determinants that confer colistin resistance among the Enterobacterales isolated from foods, animals, and humans create a serious public health problem due to the lack of remedial choices for infections caused by these isolates. This research aimed to evaluate the potential application of the resazurin reduction-based Rapid ResaPolymyxin NP assay in detecting the susceptibility of colistin in Enterobacterales .

Methods: Colistinsusceptibility test was performed by Rapid ResaPolymyxin NP technique and compared with reference broth microdilution method (BMD). Read More

Poult Sci 2021 Apr 21;100(7):101205. Epub 2021 Apr 21.

College of Veterinary Medicine, Jeonbuk National University, Iksan Campus, 54596, Iksan, Republic of Korea. Electronic address:

The present study describes the generation of Salmonella enteritidis (SE) ghosts with a surface decorated Salmonella Typhimurium (ST) flagellin (FliC) antigen for immune enhancement and strain-specific protection. The ghosts were generated by biological means using pJHL184::fliC temperature inducible plasmid where the lysis occurs by phage PhiX174 lysis gene E expression. Being an inactivated strain, no environmental contamination was observed by fecal shedding upon inoculation into the chicken. Read More

iScience 2021 May 20;24(5):102454. Epub 2021 Apr 20.

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

Nearly all clinical isolates of Typhi, the cause of typhoid fever, are antibiotic resistant. All Typhi isolates secrete an AB exotoxin called typhoid toxin to benefit the pathogen during infection. Here, we demonstrate that antibiotic-resistant Typhi secretes typhoid toxin continuously during infection regardless of antibiotic treatment. Read More

Front Microbiol 2021 25;12:663210. Epub 2021 May 25.

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

is the primary cause of community-acquired foodborne infections, so its resistance to antimicrobials, such as aminoglycosides, is a public health issue. Of concern, aminoglycoside resistance in is increasing rapidly. Here, we performed a retrospective study evaluating the prevalence of harboring -mediated aminoglycoside resistance in community-acquired infections and in food or environmental sources. Read More

J Pak Med Assoc 2021 Jun;71(6):1639-1643

Department of Microbiology, PNS Shifa Hospital, Karachi, Pakistan.

Objective: To see the efficacy of rapid colour test for the sensitivity of ceftriaxone against clinical isolates of salmonella typhi.

Methods: The cross-sectional validation study was conducted at the Department of Microbiology, Pakistan Navy Ship Shifa Hospital, Karachi, from Nov 2018 to April 2019, and comprised clinical isolates of salmonella typhi that were obtained from five different hospitals in Karachi and Hyderabad. The isolates were tested using the rapid colour test. Read More

Front Immunol 2021 24;12:667897. Epub 2021 May 24.

Department of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United States.

A therapy that includes an oral vaccine for type 1 diabetes (T1D) using live attenuated MvP728 (ΔΔ), cytokines (IL10 and TGFβ) and preproinsulin (PPI) antigen in combination with a sub-therapeutic dose of anti-CD3 mAb was developed by our team. The vaccine combination therapy reduced insulitis and prevented and reversed diabetes in non-obese diabetic (NOD) mice. Here, we show the effectiveness of an alternative mutant (Δ) as a carrier strain, which is anticipated to have lower risks of an inflammatory response and septicemia as a result of modification in the lipopolysaccharide (LPS) detoxification of lipid A. Read More

Front Immunol 2021 24;12:637809. Epub 2021 May 24.

Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.

Iron plays an important role in host-pathogen interactions, in being an essential element for both pathogen and host metabolism, but also by impacting immune cell differentiation and anti-microbial effector pathways. Iron has been implicated to affect the differentiation of T lymphocytes during inflammation, however, so far the underlying mechanism remained elusive. In order to study the role of iron in T cell differentiation we here investigated how dietary iron supplementation affects T cell function and outcome in a model of chronic infection with the intracellular bacterium (). Read More

Front Microbiol 2021 24;12:591929. Epub 2021 May 24.

Institute of Bacterial Infections and Zoonoses, Friedrich-Loeffler-Institut, Jena, Germany.

subspecies serovar Derby (. Derby) is one of the most frequent causes for salmonellosis in humans and animals. Understanding the genetic diversity of . Read More

Microbiol Spectr 2021 Jun 9:e0000321. Epub 2021 Jun 9.

Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, Massachusetts, USA.

Gastrointestinal infections cause significant morbidity and mortality worldwide. The complexity of human biology and limited insights into host-specific infection mechanisms are key barriers to current therapeutic development. Here, we demonstrate that two-dimensional epithelial monolayers derived from human intestinal organoids, combined with like bacterial culturing conditions, provide significant advancements for the study of enteropathogens. Read More

Glob Pediatr Health 2021 31;8:2333794X211022263. Epub 2021 May 31.

KK Women's and Children's Hospital, Singapore.

We describe a case of a 10-year-old immunocompetent girl with a left renal abscess due to Group C ( serovar Oranienburg). Percutaneous drainage of the abscess was done. She also received 2 weeks of intravenous ceftriaxone, followed by 4 weeks of oral co-trimoxazole with resolution seen on ultrasound. Read More

J Coll Physicians Surg Pak 2021 Jun;30(6):750-751

Department of Neurology, University of Oklahoma Health Sciences Centre, USA.

Null. Read More