46,038 results match your criteria Salmonella Infection


Evaluation of the efficiency of using Salmonella Kentucky and Escherichia coli O119 bacteriophages in the treatment and prevention of salmonellosis and colibacillosis in broiler chickens.

Lett Appl Microbiol 2020 Jul 6. Epub 2020 Jul 6.

Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agriculture Research Center Giza, Giza, Egypt.

Phage therapy is considered an alternative modality in the treatment of different bacterial diseases. However, their therapeutic and preventive roles against infections caused by S.Kentucky and E. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/lam.13347DOI Listing

The European Union One Health 2018 Zoonoses Report.

Authors:

EFSA J 2019 Dec 11;17(12):e05926. Epub 2019 Dec 11.

This report of the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring activities carried out in 2018 in 36 European countries (28 Member States (MS) and 8 non-MS). The first and second most commonly reported zoonoses in humans were campylobacteriosis and salmonellosis, respectively. The European Union (EU) trend for confirmed human cases of these two diseases was stable during 2014-2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2903/j.efsa.2019.5926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055727PMC
December 2019

Source Tracking Based on Core Genome SNV and CRISPR Typing of Serovar Heidelberg Isolates Involved in Foodborne Outbreaks in Québec, 2012.

Front Microbiol 2020 17;11:1317. Epub 2020 Jun 17.

Laboratoire de Santé Publique du Québec, Institut National de Santé Publique du Québec, Sainte-Anne-de-Bellevue, QC, Canada.

Whole-genome sequencing (WGS) is the method of choice for bacterial subtyping and it is rapidly replacing the more traditional methods such as pulsed-field gel electrophoresis (PFGE). Here we used the high-resolution core genome single nucleotide variant (cgSNV) typing method to characterize clinical and food from serovar Heidelberg isolates in the context of source attribution. Additionally, clustered regularly interspaced short palindromic repeats (CRISPR) analysis was included to further support this method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2020.01317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311582PMC

Temporospatial shifts within commercial laboratory mouse gut microbiota impact experimental reproducibility.

BMC Biol 2020 Jul 3;18(1):83. Epub 2020 Jul 3.

Department of Microbiology and Immunology, University of Louisville, Louisville, KY, 40202, USA.

Background: Experimental reproducibility in mouse models is impacted by both genetics and environment. The generation of reproducible data is critical for the biomedical enterprise and has become a major concern for the scientific community and funding agencies alike. Among the factors that impact reproducibility in experimental mouse models is the variable composition of the microbiota in mice supplied by different commercial vendors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12915-020-00810-7DOI Listing

Genetic diversity of subsp. serovar Enteritidis in the Siberia and Far East of Russia based on plasmid profiles.

AIMS Microbiol 2020 8;6(2):106-120. Epub 2020 May 8.

Laboratory of Molecular Epidemiology and Ecology of Pathogenic Bacteria, Somov Institute of Epidemiology and Microbiology, Vladivostok, Russia.

For the first time, in the literature review we presents the molecular genetic structure of Enteritidis populations in Russia, and particularly, in Siberia and the Far East of the country. Pathogen population in Russia has been compared with populations circulating in different countries of the world. It has been shown that the microbial population is heterogeneous, but it is possible to identify the dominant and main genotypes, which determine up to 90% of the total population morbidity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3934/microbiol.2020007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326731PMC

The protective capacity of anti-O4 antigen antibodies against Salmonella infection is influenced by the presence or absence of the O5 antigen.

Vaccine 2020 Jun 29. Epub 2020 Jun 29.

National Institute of Animal Health, NARO, 3-1-5, Kannondai, Tsukuba, Ibaraki 305-0856, Japan. Electronic address:

Anti-O-antigen antibodies, such as anti-O4 antigen IgG, induce protective immunity against Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2020.06.054DOI Listing

Dietary supplementation with vitamin C ameliorates the adverse effects of Salmonella Enteritidis-challenge in broilers by shaping intestinal microbiota.

Poult Sci 2020 Jul 24;99(7):3663-3674. Epub 2020 Apr 24.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China. Electronic address:

Salmonella Enteritidis (SE) infection is not only a leading cause of poor production performance and compromised animal welfare in broilers but also a potential threat to public health. Two experiments were conducted to evaluate the effects of dietary supplemental vitamin C (VC) on SE challenged-broilers. In experiment 1, one hundred eighty 1-day-old Arbor Acre broilers were randomly allocated into 3 treatments, with 0, 500, or 1,000 mg/kg VC included in the diet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psj.2020.03.062DOI Listing

A rapid novel visualized loop-mediated isothermal amplification method for Salmonella detection targeting at fimW gene.

Poult Sci 2020 Jul 25;99(7):3637-3642. Epub 2020 Apr 25.

National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Key Laboratory of Zoonoses, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Salmonella infection causes huge losses in the poultry industry worldwide. With the aim to prevent infectious diseases caused by Salmonella and to achieve rapid visualized Salmonella detection in poultry production, we used cresol red as an indicator to develop a novel visualized loop-mediated isothermal amplification method that targets the Salmonella fimW gene firstly in related field. The detection limit was 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psj.2020.03.045DOI Listing

High genetic similarity between non-typhoidal Salmonella isolated from paired blood and stool samples of children in the Democratic Republic of the Congo.

PLoS Negl Trop Dis 2020 Jul 2;14(7):e0008377. Epub 2020 Jul 2.

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Non-typhoidal Salmonella (NTS) serotypes Typhimurium and Enteritidis are a major cause of bloodstream infections in children in sub-Saharan Africa but their reservoir is unknown. We compared pairs of NTS blood and stool isolates (with the same NTS serotype recovered in the same patient) for genetic similarity.

Methods: Between November 2013 and April 2017, hospital-admitted children (29 days to 14 years) with culture-confirmed NTS bloodstream infections were enrolled in a cross-sectional study at Kisantu Hospital, DR Congo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0008377DOI Listing

Salmonellosis Outbreak Detected by Automated Spatiotemporal Analysis - New York City, May-June 2019.

MMWR Morb Mortal Wkly Rep 2020 Jul 3;69(26):815-819. Epub 2020 Jul 3.

In May 2019, the New York City Department of Health and Mental Hygiene (NYCDOHMH) detected an unusual cluster of five salmonellosis patients via automated spatiotemporal analysis of notifiable diseases using free SaTScan software (1). Within 1 day of cluster detection, graduate student interviewers determined that three of the patients had eaten prepared food from the same grocery store (establishment A) located inside the cluster area. NYCDOHMH initiated an investigation to identify additional cases, establish the cause, and provide control recommendations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15585/mmwr.mm6926a2DOI Listing

Dual role of splenic mononuclear and polymorphonuclear cells in the outcome of ciprofloxacin treatment of Salmonella enterica infections.

J Antimicrob Chemother 2020 Jul 1. Epub 2020 Jul 1.

Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.

Objectives: To determine the immune cell populations associated with Salmonella enterica serovar Typhimurium before and after ciprofloxacin treatment using a murine model of systemic infection. The effect of depletion of immune cells associating with Salmonella on treatment outcome was also determined.

Methods: We infected mice with a Salmonella enterica serovar Typhimurium strain expressing GFP and used multicolour flow cytometry to identify splenic immune cell populations associating with GFP-positive Salmonella before and after treatment with ciprofloxacin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dkaa249DOI Listing

Spatial and space-time clustering and demographic characteristics of human nontyphoidal Salmonella infections with major serotypes in Toronto, Canada.

PLoS One 2020 1;15(7):e0235291. Epub 2020 Jul 1.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

Nontyphoidal Salmonella enterica (NTS) causes a substantial health burden to human populations in Canada and worldwide. Exposure sources and demographic factors vary by location and can therefore have a major impact on salmonellosis clustering. We evaluated major NTS serotypes: S. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235291PLOS

Protective effect and mechanism of Monascus-fermented red yeast rice against colitis caused by Salmonella enterica serotype Typhimurium ATCC 14028.

Food Funct 2020 Jul 1. Epub 2020 Jul 1.

State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China. and Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.

Red yeast rice (RYR), a traditional Chinese fermented food, has the effect of lowering blood lipid and cholesterol, but little information is available about whether RYR can inhibit pathogenic bacterial infection in vivo. The present study explored the effect of RYR on Salmonella enterica-induced intestinal inflammation and gut microbiota dysbiosis in mice as well as the underlying anti-inflammatory mechanism. Results showed that RYR can alleviate S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0fo01017kDOI Listing

UPΦ phages, a new group of filamentous phages found in several members of .

Virus Evol 2020 Jan 22;6(1):veaa030. Epub 2020 Jun 22.

Department of Biology, Loyola University Chicago, 1032 W Sheridan Rd, Chicago, IL 60660, USA.

Filamentous phages establish chronic infections in their bacterial hosts, and new phages are secreted by infected bacteria for multiple generations, typically without causing host death. Often, these viruses integrate in their host's genome by co-opting the host's XerCD recombinase system. In several cases, these viruses also encode genes that increase bacterial virulence in plants and animals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ve/veaa030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307601PMC
January 2020

The diagnosis and successful replication of a clinical case of Duck Spleen Necrosis Disease: An experimental co-infection of an emerging unique reovirus and Salmonella indiana reveals the roles of each of the pathogens.

Vet Microbiol 2020 Jul 19;246:108723. Epub 2020 May 19.

Institute for Poultry Science and Health, Guangxi University, Nanning, Guangxi, 530005, China. Electronic address:

Duck spleen necrosis disease (DSND) is an emerging infectious disease that causes significant economic loss in the duck industry. In 2018, a duck reovirus (named DRV/GX-Y7) and Salmonella indiana were both isolated from the spleens and livers of diseased ducks with DSND in China. The DRV/GX-Y7 strain could propagate in the Vero, LMH, DF-1 and DEF cells with obvious cytopathic effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetmic.2020.108723DOI Listing

Prevalence and genomic characterization of Salmonella Weltevreden in commercial pig feed.

Vet Microbiol 2020 Jul 16;246:108725. Epub 2020 May 16.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore. Electronic address:

Viet Nam is the world's fifth largest producer of pork meat. Salmonella is frequently found at farm level; however, risk factors for Salmonella infection in pigs have not been thoroughly investigated in the production system. In the current study, 123 commercial feed samples were obtained from 103 small, medium and large-scale pig farms in Viet Nam and investigated for the presence of Salmonella in 25 g of feed using the ISO 6579:2002/Cor 1:2004 method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetmic.2020.108725DOI Listing

Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance.

Diagnostics (Basel) 2020 Jun 28;10(7). Epub 2020 Jun 28.

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia.

Paratyphoid fever is caused by the bacterium serovar Paratyphi (A, B and C), and contributes significantly to global disease burden. One of the major challenges in the diagnosis of paratyphoid fever is the lack of a proper gold standard. Given the absence of a licensed vaccine against Paratyphi, this diagnostic gap leads to inappropriate antibiotics use, thus, enhancing antimicrobial resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/diagnostics10070438DOI Listing

Etiology of acute Gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study.

PLoS Negl Trop Dis 2020 Jun 30;14(6):e0008375. Epub 2020 Jun 30.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

Background: Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low- and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing etiology of AGE and associated risk factors in Latin America, including Colombia, is essential to understand the epidemiology of these infections. The primary objectives of this study were to describe etiology of moderate to severe AGE in children less than 5 years of age from Bucaramanga, Colombia, a middle-income country in Latin American, and to identify the presence of emerging E. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0008375DOI Listing

Mendelian Susceptibility to Mycobacterial Disease (MSMD): Clinical and Genetic Features of 32 Iranian Patients.

J Clin Immunol 2020 Jun 30. Epub 2020 Jun 30.

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare congenital condition characterized by a selective predisposition to infections caused by weakly virulent mycobacteria and other types of intra-macrophagic pathogens. The 16 genes associated with MSMD display a considerable level of allelic heterogeneity, accounting for 31 distinct disorders with variable clinical presentations and prognosis. Most of MSMD deficiencies are isolated, referred to as selective susceptibility to mycobacterial diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10875-020-00813-7DOI Listing

Antibodies and protection in systemic infections: do we still have more questions than answers?

Infect Immun 2020 Jun 29. Epub 2020 Jun 29.

GSK Vaccines institute for Global Health, Via Fiorentina 1, 53100, Siena (Italy).

causes grave systemic infections in humans and other animals and provides a paradigm for other diseases where the bacteria have both intracellular and extracellular lifestyles.New generations of vaccines rely on the essential contribution of the antibody responses for their protection. The quality, antigen specificity and functions associated with antibody responses to this pathogen have been elusive for a long time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/IAI.00219-20DOI Listing

Intracellular delivery, accumulation, and discrepancy in antibacterial activity of four enrofloxacin-loaded fatty acid solid lipid nanoparticles.

Colloids Surf B Biointerfaces 2020 Jun 15;194:111196. Epub 2020 Jun 15.

National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, Hubei 430070, China. Electronic address:

Four fatty acid-solid lipid nanoparticles (SLNs) were formulated and evaluated for intracellular delivery, accumulation, as well as discrepancy in antimicrobial efficacy of their loaded enrofloxacin by using RAW 264.7 cells. The delivery efficacy of enrofloxacin into the macrophages by docosanoic acid SLNs (DAS), octadecanoic acid SLNs (OAS), hexadecanoic acid SLNs (HAS), and tetradecanoic acid SLNs (TAS) were 26. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2020.111196DOI Listing

A farm-to-fork quantitative risk assessment model for Salmonella Heidelberg resistant to third-generation cephalosporins in broiler chickens in Canada.

Int J Food Microbiol 2020 Feb 14;330:108559. Epub 2020 Feb 14.

Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, Guelph, ON, Canada. Electronic address:

Salmonella Heidelberg resistant to ceftiofur (a third-generation cephalosporin antimicrobial agent) in broiler chicken products pose a risk to public health in Canada. The objective of this study was to assess the extent of that risk and to evaluate the effect of intervention measures along the agri-food chain. A stochastic farm-to-fork quantitative microbial risk assessment model was developed following the Codex Alimentarius Guidelines for Risk Analysis of Foodborne Antimicrobial Resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108559DOI Listing
February 2020

Development of multiplex oligonucleotide microarray for simultaneous detection of six swine pathogens.

J Virol Methods 2020 Jun 26:113921. Epub 2020 Jun 26.

College of Veterinary Medicine, Nanjing Agricultural University, China.

In order to establish a high-throughput identification technique that simultaneously detects six major pathogens including APP, HPS, PRRSV, Mhp, PCV-2 and CSFV, six pairs of primers and probes were designed based on the specific conservative sequences of the pathogens, a multiplex PCR system was developed, hybrid parameters were optimized, and evaluation of the technology was performed. The results showed that the present detection method had a sensitivity of 5.8 × 10copies/μL for APP, 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jviromet.2020.113921DOI Listing

Mice Deficient in T-bet Form Inducible NO Synthase-Positive Granulomas That Fail to Constrain .

J Immunol 2020 Jun 26. Epub 2020 Jun 26.

Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom;

Clearance of intracellular infections caused by Typhimurium (STm) requires IFN-γ and the Th1-associated transcription factor T-bet. Nevertheless, whereas IFN-γ mice succumb rapidly to STm infections, T-bet mice do not. In this study, we assess the anatomy of immune responses and the relationship with bacterial localization in the spleens and livers of STm-infected IFN-γ and T-bet mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.2000089DOI Listing

Municipal wastewater surveillance reveals high community disease burden of rarely reported and possibly subclinical Derby strain.

Appl Environ Microbiol 2020 Jun 26. Epub 2020 Jun 26.

Department of Civil and Environmental Engineering, University of Hawaii at Manoa, Honolulu, HI 96822

Clinical surveillance of enteric pathogens like is integral to track outbreaks and endemic disease trends. However, clinic-centered disease monitoring biases toward detection of severe cases and underestimates the incidence of self-limiting gastroenteritis and asymptomatic strains. Monitoring pathogen loads and diversity in municipal wastewater (MW) can provide insight into asymptomatic or subclinical infections which are not reflected in clinical cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AEM.00814-20DOI Listing

Spinal epidural abscess caused by non-typhoidal Salmonella: A case report and literature review.

J Infect Chemother 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathogen, Infection and Immunity, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan.

Non-typhoidal Salmonellae are Gram negative bacilli commonly causing self-limiting gastroenteritis, representing a public health issue particularly in tropical countries. Further, the epidemiology of invasive infection by non-typhoidal Salmonella species is poorly understood. Herein, we presented a case of an unusual Salmonella enterica subsp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiac.2020.05.016DOI Listing

The application research of xTAG GPP multiplex PCR in the diagnosis of persistent and chronic diarrhea in children.

BMC Pediatr 2020 Jun 26;20(1):309. Epub 2020 Jun 26.

Department of Gastroenterology, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, 210008, Jiangsu Province, China.

Background: Persistent and chronic diarrhea is difficult to treat, and infection is still the main cause. In this study, we investigate the application value of xTAG gastrointestinal pathogen panel (xTAG GPP) multiplex PCR in the early diagnosis of persistent and chronic diarrhea in children and to understand the epidemiology of intestinal diarrhea pathogens.

Methods: One hundred ninety-nine specimens were collected from Nanjing Children's Hospital Affiliated to Nanjing Medical University (Nanjing, China). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-020-02206-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318512PMC

Genomic characterization of Uzaramo for human invasive infection.

Microb Genom 2020 Jun 26. Epub 2020 Jun 26.

Zhejiang Provincial Laboratory of Preventive Veterinary Medicine, Hangzhou 310058, PR China.

is composed of a wide variety of serovars, causing human self-limited gastrointestinal illnesses or invasive infections. Invasive non-typhoidal (iNTS) is well documented, with high mortality for children and immunocompromised adults in sub-Saharan Africa and has recently been reported in Southeast Asia. However, iNTS in China remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/mgen.0.000401DOI Listing

Prevalence and Drug Resistance of in Dogs and Cats in Xuzhou, China.

J Vet Res 2020 Jun 12;64(2):263-268. Epub 2020 May 12.

Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225009, China.

Introduction: Salmonellosis is a zoonotic disease, and spp. can sometimes be found in dogs and cats, posing a risk to human health. In this study, the prevalence and antimicrobial susceptibility of faecal were investigated in pet dogs and cats in Xuzhou, Jiangsu Province, China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/jvetres-2020-0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305642PMC

CRISPR 2 PCR and high resolution melting profiling for identification and characterization of clinically-relevant enterica subsp. enterica.

PeerJ 2020 16;8:e9113. Epub 2020 Jun 16.

Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, Thailand.

Background: Nontyphoidal spp. constitute a major bacterial cause of food poisoning. Each serotype causes distinct virulence to humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7717/peerj.9113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304428PMC

Estimating deaths from foodborne disease in the UK for 11 key pathogens.

BMJ Open Gastroenterol 2020 Jun;7(1)

Information Team, West Suffolk NHS Foundation Trust, Bury St Edmunds, UK.

Objective: To estimate the number of deaths from foodborne disease in the UK from 11 key pathogens.

Design: Four different models were developed using data from a range of sources. These included enhanced surveillance, outbreaks, death certificates and hospital episode statistics data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjgast-2020-000377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319714PMC

Multiple Salmonella-pathogenicity island 2 effectors are required to facilitate bacterial establishment of its intracellular niche and virulence.

PLoS One 2020 25;15(6):e0235020. Epub 2020 Jun 25.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.

The pathogenesis of Salmonella Typhimurium depends on the bacterium's ability to survive and replicate within host cells. The formation and maintenance of a unique membrane-bound compartment, termed the Salmonella-containing vacuole (SCV), is essential for S. Typhimurium pathogenesis. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235020PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316343PMC

City sanitation and socioeconomics predict rat zoonotic infection across diverse neighbourhoods.

Zoonoses Public Health 2020 Jun 25. Epub 2020 Jun 25.

Department of Conservation and Science, Lincoln Park Zoo, Chicago, IL, USA.

Rat-associated zoonoses transmitted through faeces or urine are of particular concern for public health because environmental exposure in homes and businesses may be frequent and undetected. To identify times and locations with greater public health risks from rats, we investigated whether rat characteristics, environmental features, socioeconomic factors, or season could predict rat infection risk across diverse urban neighbourhoods. In partnership with a pest management company, we sampled rats in 13 community areas along an income gradient in Chicago, a large city where concern about rats has increased in recent years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/zph.12748DOI Listing

Detection of Colistin Resistance in Using MALDIxin Test on the Routine MALDI Biotyper Sirius Mass Spectrometer.

Front Microbiol 2020 3;11:1141. Epub 2020 Jun 3.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom.

Resistance to polymyxins in most Gram-negative bacteria arises from chemical modifications to the lipid A portion of their lipopolysaccharide (LPS) mediated by chromosomally encoded mutations or the recently discovered plasmid-encoded genes that have further complicated the landscape of colistin resistance. Currently, minimal inhibitory concentration (MIC) determination by broth microdilution, the gold standard for the detection of polymyxin resistance, is time consuming (24 h) and challenging to perform in clinical and veterinary laboratories. Here we present the use of the MALDIxin to detect colistin resistant using the MALDxin test on the routine matrix-assisted laser desorption ionization (MALDI) Biotyper Sirius system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2020.01141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283459PMC
June 2020
3.941 Impact Factor

A pain in the neck: Salmonella spp. as an unusual cause of a thyroid abscess. A case report and review of the literature.

BMC Infect Dis 2020 Jun 22;20(1):436. Epub 2020 Jun 22.

Division of Otolaryngology Head and Neck Surgery, Department of Surgery, Dalhousie University, 5850 University Avenue, Halifax, NS, B3K 6R8, Canada.

Background: Thyroid gland infections are rare. Their incidence is estimated to be less than 1% in immunocompromised hosts. Most common pathogens isolated are Gram positive aerobic cocci. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-020-05161-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310241PMC

Investigation into In Vitro and In Vivo Models to Select Cheese Yeasts as Probiotic Candidates for their Preventive Effects against Typhimurium.

Microorganisms 2020 Jun 18;8(6). Epub 2020 Jun 18.

Université Clermont Auvergne, INRAE, VetAgro Sup, F-15000 Aurillac, France.

The design of multiscale strategies integrating in vitro and in vivo models is necessary for the selection of new probiotics. In this regard, we developed a screening assay based on the investigation of the potential of yeasts from cheese as probiotics against the pathogen Typhimurium UPsm1 (ST). Two yeasts isolated from raw-milk cheese ( 16, Sc16; 25, Dh25), as well as subspecies (CNCM I-1079, Sb1079), were tested against ST by applying in vitro and in vivo tests. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/microorganisms8060922DOI Listing

Salmonella Typhi and Paratyphi A infections in Cambodian children, 2012 - 2016.

Int J Infect Dis 2020 Jun 19. Epub 2020 Jun 19.

Cambodia Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom. Electronic address:

Objectives: Enteric fever remains an important diagnostic and treatment challenge in febrile children living in the tropics. In the context of a national Salmonella enterica serovar Paratyphi A outbreak, this retrospective study objective was to compare features of S. Typhi and S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2020.06.054DOI Listing

The MAIT TCRβ chain contributes to discrimination of microbial ligand.

Immunol Cell Biol 2020 Jun 22. Epub 2020 Jun 22.

Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.

Mucosal Associated Invariant T (MAIT) cells are key players in the immune response against microbial infection. The MAIT T cell receptor (TCR) recognizes a diverse array of microbial ligands and recent reports have highlighted the variability in the MAIT TCR that could further contribute to discrimination of ligand. The MAIT TCR CDR3β sequence displays a high level of diversity across individuals and clonotype usage appears to be dependent on antigenic exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imcb.12370DOI Listing

Milk phospholipid supplementation mediates colonization resistance of mice against Salmonella infection in association with modification of gut microbiota.

Food Funct 2020 Jun 22. Epub 2020 Jun 22.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.

Gut microbiota-mediated colonization resistance against enteropathogens is known to be greatly influenced by bioactive food compounds. This work aims to investigate the effects of milk phospholipid (MP) supplementation on the colonization resistance of mice to Salmonella enterica serovar Typhimurium (S. Typhimurium) infection, with the focus mainly on the change of gut microbiota. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0fo00883dDOI Listing

Deletion of the gene augments expression of Pathogenicity Island (SPI)-1 and metal ion uptake genes leading to the accumulation of bactericidal hydroxyl radicals and host pro-inflammatory cytokine-mediated rapid intracellular clearance.

Gut Microbes 2020 Nov 21;11(6):1695-1712. Epub 2020 Jun 21.

College of Veterinary Medicine, Jeonbuk National University , Iksan, Republic of Korea.

In the present study, we characterized the involvement of Lon protease in bacterial virulence and intracellular survival in under abiotic stress conditions resembling the conditions of a natural infection. Wild type (JOL401) and the mutant (JOL909) Typhimurium were exposed to low temperature, pH, osmotic, and oxidative stress conditions and changes in gene expression profiles related to virulence and metal ion uptake were investigated. Expression of candidate genes and of Pathogenicity Island (SPI)-1 and and of SPI-2 revealed that Lon protease controls SPI-1 genes and not SPI-2 genes under all stress conditions tested. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19490976.2020.1777923DOI Listing
November 2020

Novel Noncompetitive Type Three Secretion System ATPase Inhibitors Shut Down Effector Secretion.

Biochemistry 2020 Jun 30. Epub 2020 Jun 30.

Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322, United States.

is the causative agent of bacillary dysentery and is responsible for an estimated 165 million infections and 600,000 deaths annually. Like many Gram-negative pathogens, relies on a type three secretion system (T3SS) to initiate and sustain infection by directly injecting effector proteins into host cells. Protein secretion through the needle-like injectisome and overall virulence rely on the T3SS ATPase Spa47, making it a likely means for T3SS regulation and an attractive target for therapeutic small molecule inhibitors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.0c00431DOI Listing

Atypical in a Horse: Implications for Hospital Safety.

Case Rep Vet Med 2020 4;2020:7062408. Epub 2020 Jun 4.

Department of Clinical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA.

A 17-year-old Quarter Horse mare was evaluated for colic of 24-hour duration. Clinical signs and diagnostic evaluation were consistent with duodenitis-proximal jejunitis. The horse's clinical condition deteriorated despite medical treatment and was euthanized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/7062408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292965PMC

In Vitro Antibacterial Activities of Methanolic Extracts of Fruits, Seeds, and Bark of DC.

J Trop Med 2020 4;2020:2803063. Epub 2020 Jun 4.

Central Department of Botany, Tribhuvan University, Kirtipur, Kathmandu, Nepal.

Crude methanol extracts of fruits, seeds, and bark of were investigated in vitro for antimicrobial activities against 9 different bacterial strains: , , , , , , , methicillin-resistant (MRSA), and using agar well diffusion method, and the MBC values were determined. Only 5 bacteria, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/2803063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292994PMC

Identification of novel vaccine candidate against Salmonella enterica serovar Typhi by reverse vaccinology method and evaluation of its immunization.

Genomics 2020 Jun 18. Epub 2020 Jun 18.

Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran. Electronic address:

Salmonella enterica serovar Typhi (S. Typhi) is an essential enteric fever causing bacterium worldwide. Due to the emergence of multidrug-resistant strains, urgently attention is needed to prevent the global spread of them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygeno.2020.06.022DOI Listing

Molecular identification and antibiotic resistance profiling of Salmonella species isolated from chickens in eastern Turkey.

BMC Vet Res 2020 Jun 19;16(1):205. Epub 2020 Jun 19.

Department of Microbiology, Veterinary Faculty, Firat University, 23100, Elazig, Turkey.

Background: The aim of this study was to obtain quantitative data about the frequency, genotypic characterization and antibiotic resistance profiling of Salmonella agents in chicken flocks located in eastern Turkey.

Results: Feces samples representing at least 20% of the flock area were collected via sock swabs from commercial poultry flocks in the study region in addition to internal organs (liver, spleen, intestine) collected at necropsy of suspected chickens belonging to small family enterprises. The samples were analyzed by conventional bacteriological methods (ISO 6579:2002/A1:2007) for isolation, and genus specific (invA) PCR for the identification of Salmonella spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12917-020-02425-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304202PMC

Inverse association between dengue, chikungunya, and Zika virus infection and indicators of household air pollution in Santa Rosa, Guatemala: A case-control study, 2011-2018.

PLoS One 2020 19;15(6):e0234399. Epub 2020 Jun 19.

Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City, Guatemala.

Background: Dengue, chikungunya, and Zika viruses are increasingly important public health problems. Burning vegetation, leaves, and other plant products have been shown to be effective mosquito repellents for their vector, Aedes spp., but there has been scant research on whether firewood cooking smoke in households influences mosquito populations or mosquito-borne diseases. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234399PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304608PMC

Detection of spatial, temporal and space-time Salmonella Heidelberg and Salmonella Typhimurium clusters in Ontario in 2015, and comparisons to known outbreaks.

Zoonoses Public Health 2020 Jun 19. Epub 2020 Jun 19.

Department of Population Medicine, University of Guelph, Ontario Veterinary College, Guelph, Canada.

Purpose: Salmonellosis is one of several reportable diseases in Ontario (ON). Two or more cases of the same serotype that are linked to a common exposure or related to one another in time and/or space are considered a potential outbreak. While laboratory data can help to determine the molecular relatedness of cases, results may take up to several weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/zph.12741DOI Listing

Probiotics: an Antibiotic Replacement Strategy for Healthy Broilers and Productive Rearing.

Probiotics Antimicrob Proteins 2020 Jun 17. Epub 2020 Jun 17.

Department of Microbiology, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.

Pathogens develop resistance to antibiotics at a rate much faster than the discovery of new antimicrobial compounds. Reports of multidrug-resistant bacteria isolated from broilers, and the possibility that these strains may spread diseases amongst humans, prompted many European countries to ban the inclusion of antibiotics in feed. Probiotics added to broiler feed controlled a number of bacterial infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12602-020-09640-zDOI Listing

Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins.

Cell Rep 2020 06;31(11):107772

Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. Electronic address:

ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. The signals that lead to the production of extracellular ISG15 and the relationship between its two core functions remain unclear. We show that both epithelial cells and lymphocytes can secrete ISG15, which then signals in either an autocrine or paracrine manner to LFA-1-expressing cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2020.107772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297157PMC

Factors associated with occurrence of salmonellosis among children living in Mukuru slum, an urban informal settlement in Kenya.

BMC Infect Dis 2020 Jun 17;20(1):422. Epub 2020 Jun 17.

Centre for Microbiology Research, Kenya Medical Research Institute, Off Mbagathi Road, PO Box 54840-00200, Nairobi, Kenya.

Background: In Kenya, typhoid fever and invasive non-typhoidal salmonellosis present a huge burden of disease, especially in poor-resource settings where clean water supply and sanitation conditions are inadequate. The epidemiology of both diseases is poorly understood in terms of severity and risk factors. The aim of the study was to determine the disease burden and spatial distribution of salmonellosis, as well as socioeconomic and environmental risk factors for these infections, in a large informal settlement near the city of Nairobi, from 2013 to 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-020-05134-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302364PMC