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Foodborne Pathog Dis 2019 Feb 19. Epub 2019 Feb 19.

1 Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, China.

Objectives: This study aimed to trace the transmission source of Salmonella enterica serovar Typhimurium and Salmonella enterica serovar Enteritidis strains associated with enteric infections in Shanghainese children, and understand the molecular mechanism of resistance to third-generation cephalosporins and ciprofloxacin.

Materials And Methods: The profiles of pulsed-field gel electrophoresis (PFGE) were compared among the isolates from children, animal, and environment. Antimicrobial susceptibility was determined using the minimal inhibitory concentrations and Kirby-Bauer disk diffusion method. Read More

Front Vet Sci 2019 4;6. Epub 2019 Feb 4.

College of Animal Science and Technology, Southwest University, Chongqing, China.

is a pathogenic microorganism that causes a variety of serious diseases in humans and animals worldwide. The global regulator gene, , plays an important role in pathogenesis and regulates the virulence of many bacteria. Here, we identified a gene in by complementing a Choleraesuis Δ mutant, and characterized a mutant strain of . Read More

Nat Biotechnol 2019 Feb 18. Epub 2019 Feb 18.

Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.

Reproducibility in research can be compromised by both biological and technical variation, but most of the focus is on removing the latter. Here we investigate the effects of biological variation in HeLa cell lines using a systems-wide approach. We determine the degree of molecular and phenotypic variability across 14 stock HeLa samples from 13 international laboratories. Read More

Microb Genom 2019 Feb 18. Epub 2019 Feb 18.

2​National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Gastrointestinal Infections at University of Liverpool, Liverpool, UK.

We present the LiSEQ (Listeria SEQuencing) project, funded by the European Food Safety Agency (EFSA) to compare Listeria monocytogenes isolates collected in the European Union from ready-to-eat foods, compartments along the food chain (e.g. food-producing animals, food-processing environments) and humans. Read More

Germs 2018 Dec 3;8(4):178-185. Epub 2018 Dec 3.

MD, PhD, Dr Med, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado Nº 430, San Martín de Porras, Lima 31, Lima, Perú.

Introduction: The salmonelloses are among the commonest, most widespread human zoonotic infections. They have generated international networks to attempt their control, since they cause a spectrum of ailments, ranging from inapparent carrier states to full-blown, severe, sometimes deadly diarrheal and systemic disease. Rapid diagnosis is needed for a number of reasons. Read More

Immunol Lett 2019 Feb 13. Epub 2019 Feb 13.

MRC Centre for Molecular Bacteriology and Infection, Imperial College London, SW7 2AZ, UK. Electronic address:

Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4 T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by translocating effectors of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system (T3SS) into host cells. Read More

Infection 2019 Feb 15. Epub 2019 Feb 15.

Department of Infectious and Tropical Diseases, Spedali Civili, Piazzale Spedali Civili, 1, 25123, Brescia, Italy.

S. typhi infection rarely involves the genitourinary system. We report the first described case of acute epididymo-orchitis due to S. Read More

Clin Infect Dis 2019 Feb;68(Supplement_1):S34-S41

Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.

Several decades following the first estimates of the global burden of typhoidal salmonellosis (infections caused by Salmonella Typhi and Salmonella Paratyphi), this disorder remains a major cause of morbidity worldwide with an estimated 17 million cases annually. The risk factors for typhoid include poverty, poor living conditions with unsafe water and lack of adequate sanitation, and unsafe foods-all reasons for the disease burden being highest among such populations including urban slums. A recent review of typhoid trends globally and in specific countries suggests that the relative contributions of these risk factors to disease burden reduction as well as persistence have varied. Read More

Clin Infect Dis 2019 Feb;68(Supplement_1):S10-S15

Department of Medicine, University of Cambridge, United Kingdom.

Background: Salmonella infections cause a disproportionately high number of deaths in Africa, especially among poor urban populations. The increasing level of multidrug-resistant (MDR) infections is a major cause of concern in these settings where alternative effective treatment is unavailable. Other options for management of these infections must be sought. Read More

Biochimie 2019 Feb 11. Epub 2019 Feb 11.

Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, and Instituto de Química Biológica "Dr. Bernabé Bloj", Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI, San Miguel de Tucumán, Tucumán, Argentina. Electronic address:

Bacterial survive and respond to adverse changes in the environment by regulating gene transcription through two-component regulatory systems. In Salmonella Typhimurium the STM1485 gene expression is induced under low pH (4.5) during replication inside the epithelial host cell, but it is not involved in sensing or resisting to this condition. Read More

Eur J Case Rep Intern Med 2018 22;5(2):000766. Epub 2018 Feb 22.

Institute of Infectious Diseases and Epidemiology, Communicable Disease Centre, Singapore.

We describe a patient with a mycotic aneurysm. A 91-year-old man presented with recurrent episodes of bacteraemia 2 months apart. During the second presentation, he underwent magnetic resonance imaging of the left lower limb that revealed rupture of the popliteal artery with a popliteal fossa collection. Read More

Eur J Case Rep Intern Med 2018 28;5(11):000967. Epub 2018 Nov 28.

Department of Medicine, Sealand University Hospital, Køge, Denmark.

Aortitis is a rare condition and easily overlooked. It is defined as infectious or non-infectious inflammation of the aortic wall. This report describes two cases of aortitis, demonstrating the diagnostic difficulty and how diagnostic delay could have been reduced if early radiology had been performed. Read More

Trends Microbiol 2019 Feb 9. Epub 2019 Feb 9.

Michael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada. Electronic address:

The complex infection environment within hosts exerts unique stresses across tissues and cell types, selecting for phenotypic heterogeneity in bacterial populations. Pathogens maintain variability during infection as a strategy to cope with fluctuating host immune conditions, leading to diversification of virulence phenotypes. Recent improvements in single-cell analyses have revealed that distinct bacterial subpopulations contribute unique colonization and growth strategies across infection sites. Read More

Epidemiol Health 2019 9;41:e2019002. Epub 2019 Jan 9.

Busan Center for Infectious Disease Control and Prevention, Busan National University Hospital, Busan, Korea.

Objectives: This study aimed to reveal the epidemiologic characteristics of the outbreak of gastroenteritis caused by Salmonella enterica serovar Thompson in Busan Metropolitan City and to identify points for improvement to prevent of food-borne disease outbreak.

Methods: This was a case-control study. The control group comprised asymptomatic students in the same classes of the cases. Read More

Elife 2019 Feb 12;8. Epub 2019 Feb 12.

Host-Toxoplasma Interaction Laboratory, The Francis Crick Institute, London, United Kingdom.

For image-based infection biology, accurate unbiased quantification of host-pathogen interactions is essential, yet often performed manually or using limited enumeration employing simple image analysis algorithms based on image segmentation. Host protein recruitment to pathogens is often refractory to accurate automated assessment due to its heterogeneous nature. An intuitive intelligent image analysis program to assess host protein recruitment within general cellular pathogen defense is lacking. Read More

Nat Microbiol 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

When choosing antibiotics to treat bacterial infections, it is assumed that the susceptibility of the target bacteria to an antibiotic is reflected by laboratory estimates of the minimum inhibitory concentration (MIC) needed to prevent bacterial growth. A caveat of using MIC data for this purpose is heteroresistance, the presence of a resistant subpopulation in a main population of susceptible cells. We investigated the prevalence and mechanisms of heteroresistance in 41 clinical isolates of the pathogens Escherichia coli, Salmonella enterica, Klebsiella pneumoniae and Acinetobacter baumannii against 28 different antibiotics. Read More

J Clin Gastroenterol 2019 Mar;53 Suppl 1:S1-S41

Department of Gastroenterology, San Filippo Neri Hospital, Rome, Italy.

Lactobacillus rhamnosus GG (LGG) was the first strain belonging to the genus Lactobacillus to be patented in 1989 thanks to its ability to survive and to proliferate at gastric acid pH and in medium containing bile, and to adhere to enterocytes. Furthermore LGG is able to produces both a biofilm that can mechanically protect the mucosa, and different soluble factors beneficial to the gut by enhancing intestinal crypt survival, diminishing apoptosis of the intestinal epithelium, and preserving cytoskeletal integrity. Moreover LGG thanks to its lectin-like protein 1 and 2 inhibits some pathogens such as Salmonella species. Read More

Appl Environ Microbiol 2019 Feb 8. Epub 2019 Feb 8.

State Key Laboratory of Microbial Metabolism, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China

DNA is the carrier of genetic information. DNA modifications play a central role in essential physiological processes. Phosphorothioation (PT) modification involves the replacement of an oxygen atom on the DNA backbone with a sulfur atom. Read More

Molecules 2019 02 7;24(3). Epub 2019 Feb 7.

College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China.

The antibiotic resistance of has become increasingly serious due to the increased use of antibiotics, and antimicrobial peptides have been considered as an ideal antibiotic alternative. can induce macrophage apoptosis and thus further damage the immune system. The antimicrobial peptide JH-3 has been shown to have a satisfactory anti- effect in previous research, but its mechanism of action remains unknown. Read More

Diseases 2019 Feb 7;7(1). Epub 2019 Feb 7.

Department of Biology/Environmental Science, College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA.

(1) Background: infections are a major cause of illnesses in the United States. Each year around 450 people die from the disease and more than 23,000 people are hospitalized. outbreaks are commonly associated with eggs, meat and poultry. Read More

Klin Lab Diagn 2018 ;63(9):557-563

State budgetary institution of health care Infectious disease hospital, 150040 Yaroslavl, Russia.

Salmonella infections continue to be a serious problem in modern medicine. Being intestinal infections-associated pathogens, representatives of the genus Salmonella manifest themselves as pathogenic bacteria, especially in developing nosocomial infections. Given the polymorphism of clinical symptoms of salmonellosis, laboratory studies using bacteriological and serological methods are an important link in the diagnosis. Read More

Evid Based Complement Alternat Med 2019 10;2019:7631531. Epub 2019 Jan 10.

Laboratory of Research in Applied Microbiology (LAPEMA), University of Franca, Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, SP, Brazil.

Trees of the genus are native to the tropical regions of Latin America and Western Africa. sp is widely used as a popular medicine and it has various ethnopharmacological indications, including gonorrhea, bronchitis, asthma, skin ulcers, ulcers, sore throat, uterine infections, general inflammations, cancer, and leishmanioses. Kaurenoic acid is a naturally occurring diterpene found in and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer. Read More

Int J Med Microbiol 2019 Jan 31. Epub 2019 Jan 31.

Institute of Biomedicine for Brazilian Semiarid, Federal University of Ceará, 1315 Coronel Nunes de Melo, 60430-270, Fortaleza, Brazil.

Shigella/Enteroinvasive Escherichia coli (EIEC) pathotype is a major enteropathogen associated with diarrhea and malnutrition in children from developing countries. This study aimed to correlate Shigella/EIEC virulence-related genes (VRGs) with clinical symptoms, nutritional status and coenteropathogens in children from the Brazilian semiarid region. We designed a case-control study of community diarrhea in six cities of the Brazil semiarid region with 1200 children aging 2-36 months. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14335

Hepatology, Gastroenetrology and Infectious Diseases Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh.

Helicobacter pylori (H pylori) infection is the most frequent infection worldwide and it has been postulated that it predisposes to multiple enteric pathogens and diarrheal diseases. Salmonella infection is common in tropical and under developed communities and is associated with wide range of diseases from gastroenteritis to typhoid fever. This study aimed at detecting the impact of H pylori infection on the incidence of salmonella infections. Read More

Plasmid 2019 Feb 5;102:1-5. Epub 2019 Feb 5.

Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Electronic address:

Azithromycin represents a valid therapeutic option for gastrointestinal and systemic infections caused by multidrug resistant (MDR) diarrheagenic Escherichia coli, Shigella and Salmonella species. However, acquired macrolide resistance in these species has been increasingly described, mostly related to macrolide modifying enzymes encoded by mph- and erm-type genes. In this study, we characterized the first bla/ermB-carrying IncI1 plasmid from Latin America, which was detected in a MDR E. Read More

Gut Microbes 2019 Feb 6:1-16. Epub 2019 Feb 6.

a Department of Microbiology and Physiological Systems , University of Massachusetts Medical School , Worcester , MA , USA.

SifA is a bi-functional Type III Secretion System (T3SS) effector protein that plays an important role in Salmonella virulence. The N-terminal domain of SifA binds SifA-Kinesin-Interacting-Protein (SKIP), and via an interaction with kinesin, forms tubular membrane extensions called Sif filaments (Sifs) that emanate from the Salmonella Containing Vacuole (SCV). The C-terminal domain of SifA harbors a WxxxE motif that functions to mimic active host cell GTPases. Read More

Zoonoses Public Health 2019 Feb 5. Epub 2019 Feb 5.

Integrative Research Center for Veterinary Preventive Medicine, Faculty of Veterinary Medicine, Chiang Mai University, Muang, Thailand.

Human salmonellosis is a major public health problem worldwide. Infections can pass to humans by contact with contaminated substances in the food chain. This study aimed to determine the prevalence and contamination levels of Salmonella isolated from pork, chicken and beef sold in different types of retail stores in Chiang Mai and Lamphun provinces and to investigate the genetic relatedness among Salmonella isolates in food chains in that area. Read More

MBio 2019 Feb 5;10(1). Epub 2019 Feb 5.

Department of Internal Medicine II (Infectious Diseases, Immunology, Rheumatology and Pneumology), Medical University of Innsbruck, Innsbruck, Austria

We have recently shown that the catecholamine dopamine regulates cellular iron homeostasis in macrophages. As iron is an essential nutrient for microbes, and intracellular iron availability affects the growth of intracellular bacteria, we studied whether dopamine administration impacts the course of infections. Dopamine was found to promote the growth of both in culture and within bone marrow-derived macrophages, which was dependent on increased bacterial iron acquisition. Read More

Pathog Glob Health 2019 Feb 6:1-7. Epub 2019 Feb 6.

a Department of Clinical Microbiology , Christian Medical College and Hospital , Vellore , India.

Non-typhoidal Salmonella (NTS) are foodborne pathogens that are responsible for self-limiting gastroenteritis in humans. The present study aims at the molecular characterisation and comparative genomics of Salmonella enterica serovar Senftenberg strain P5558 isolated from the pus samples of a patient suffering from stump infection. The isolate was subjected to serotyping and antimicrobial susceptibility test to understand the phenotypical characteristics. Read More

Sci Rep 2019 Feb 4;9(1):1344. Epub 2019 Feb 4.

Public Health England, National Infection Service, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.

The multidrug resistant (MDR) opportunistic pathogen Klebsiella pneumoniae has previously been shown to adapt to chlorhexidine by increasing expression of the MFS efflux pump smvA. Here we show that loss of the regulator SmvR, through adaptation to chlorhexidine, results in increased resistance to a number of cationic biocides in K. pneumoniae and other members of the Enterobacteriaceae. Read More

PLoS One 2019 4;14(2):e0211584. Epub 2019 Feb 4.

Department of Microbial Physiology, Humboldt Universität zu Berlin, Berlin, Germany.

The Cpx-envelope stress system regulates the expression of virulence factors in many Gram-negative pathogens. In Salmonella enterica serovar Typhimurium deletion of the sensor kinase CpxA but not of the response regulator CpxR results in the down regulation of the key regulator for invasion, HilA encoded by the Salmonella pathogenicity island 1 (SPI-1). Here, we provide evidence that cpxA deletion interferes with dephosphorylation of CpxR resulting in increased levels of active CpxR and consequently in misregulation of target genes. Read More

Biochemistry 2019 Feb 15. Epub 2019 Feb 15.

Department of Biochemistry and Biophysics , Texas A&M University , College Station , Texas 77843 , United States.

Non-typhoidal Salmonella can colonize the gastrointestinal system of cattle and can also cause significant food-borne disease in humans. The use of a library of single-gene deletions in Salmonella enterica serotype Typhimurium allowed identification of several proteins that are under selection in the intestine of cattle. STM2437 ( yfeJ) encodes one of these proteins, and it is currently annotated as a type I glutamine amidotransferase. Read More

Placenta 2019 Jan 22;75:23-26. Epub 2018 Nov 22.

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address:

The human placenta functions as an innate immune barrier to prevent fetal infection. However, the molecular mechanisms accounting for placental resistance to pathogens are currently poorly understood. The solute carrier family 11 member 1 (SLC11A1) is a divalent cation transporter expressed primarily by macrophages and neutrophils that is essential for controlling infections by intracellular pathogens such as Salmonella, Leishmania and Mycobacteria. Read More

Anal Chim Acta 2019 Apr 21;1054:157-166. Epub 2018 Dec 21.

Department of Physics, Chemistry and Biology, Linkӧping University, Linköping, 58185, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Linköping University, Linköping, Sweden. Electronic address:

Salmonella is a leading source of bacterial foodborne illness in humans, causing gastroenteritis outbreaks with bacteraemia occurrences that can lead to clinical complications and death. Eggs, poultry and pig products are considered as the main carriers of the pathogenic Salmonella for humans. To prevent this relevant zoonosis, key changes in food safety regulations were undertaken to improve controls in the food production chain. Read More

Mol Genet Genomics 2019 Feb 1. Epub 2019 Feb 1.

Systemomics Center, College of Pharmacy, and Genomics Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.

Antimicrobial resistance makes pathogenic bacteria hard to control, but little is known about the general processes of resistance gain or loss. Here, we compared distinct S. typhimurium DT104 strains resistant to zero, two, five, or more of the tested antimicrobials. Read More

Microb Cell Fact 2019 Jan 31;18(1):21. Epub 2019 Jan 31.

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.

Background: Infectious bursal disease (IBD) is an acute contagious immunosuppressive disease which lead to acute bursal injury and immune dysfunction in poultry. It has caused heavy economic losses in the commercial poultry industry for many years in worldwide. Attenuated live vaccine has widely used in poultry showing some promising signs against IBDV infection. Read More

BMC Genomics 2019 Jan 31;20(1):99. Epub 2019 Jan 31.

Laboratorio de Patógenos Bacterianos Intracelulares, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB-CSIC), Madrid, Spain.

Background: Salmonella enterica subsp. diarizonae (IIIb) is frequently isolated from the environment, cold-blooded reptiles, sheep and humans; however only a few studies describe the isolation of this subspecies from invasive human infections. The factors contributing to this unusual behavior are currently unknown. Read More

Microb Pathog 2019 Jan 29;129:1-6. Epub 2019 Jan 29.

Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China. Electronic address:

To persist in the host, Salmonella is known to facultatively parasitize cells to escape the immune response. Intracellular Salmonella enterica can replicate using effector proteins translocated across the Salmonella-containing vacuolar membrane via a type III secretion system (T3SS) encoded by Salmonella pathogenicity island-2 (SPI-2). One of these factors, Salmonella secreted factor L (SseL), is a deubiquitinase that contributes to the virulence of Salmonella Typhimurium in mice by inhibiting the cellular NF-κB inflammatory pathway. Read More

Ter Arkh 2018 Nov;90(11):90-97

Infectious Clinical Hospital №2, Moscow City Health Department, Moscow, Russia.

The article describes the clinical observation with an unfavorable outcome of the generalized form of salmonella infection caused by Salmonella typhimurium group B in a woman of 60 years without immunodeficiency, complicated by the development of multiple abscesses of the lower parts of abdominal cavity, probably of appendicular origin. In a short literary review, the pathogenetic mechanisms that contribute to the formation of generalized and extraintestinal forms of salmonella infection are discussed. Read More

PeerJ 2019 25;7:e6359. Epub 2019 Jan 25.

Joint International Research Laboratory of Agriculture & Agri-Product Safety of the Ministry of Education, Yangzhou University, Yangzhou, China.

Persistent colonization of the avian reproductive tract by serovar Enteritidis (SE) negatively affects egg production and contaminates the egg. The immune function of the ovary and oviduct is essential for protection from infection and for the production of wholesome eggs. However, the immune response of laying ducks during SE infection is not well-understood. Read More

Pathogens 2019 Jan 29;8(1). Epub 2019 Jan 29.

UCIBIO@REQUIMTE, Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Portugal; Rua de Jorge Viterbo Ferreira nº 228, 4050-313 Porto, Portugal.

Salmonellosis remains one of the most frequent foodborne zoonosis, constituting a worldwide major public health concern. The most frequent sources of human infections are food products of animal origin, being pork meat one of the most relevant. Currently, particular pig food production well-adapted and persistent serotypes (e. Read More

J Med Microbiol 2019 Jan 30. Epub 2019 Jan 30.

3​Department of Laboratory Medicine, National University Hospital, Singapore.

Field investigations were conducted after a small cluster of food poisoning involving six cases was reported. While no stool samples were available from the cases for microbiological testing, Salmonella species was found to be present in the stools of food handlers with gastroenteritis symptoms. Four Salmonella isolates recovered from the food handlers were retrospectively investigated at the genome level using whole-genome sequencing (WGS). Read More

MBio 2019 Jan 29;10(1). Epub 2019 Jan 29.

Biology of Vector-Borne Viruses Section, Laboratory of Virology, Rocky Mountain Laboratories, NIAID/NIH, Hamilton, Montana, USA.

The tick transmits a number of pathogens, including tick-borne flaviviruses (TBFVs). In the United States, confirmed human infections with the Powassan virus (POWV) TBFV have a fatality rate of ∼10% and are increasing in incidence. Tick salivary glands (SGs) serve as an organ barrier to TBFV transmission, and little is known regarding the location of TBFV infection in SGs from fed ticks. Read More

Euro Surveill 2019 Jan;24(4)

Division for Infection Control and Environmental Health, Norwegian Institute of Public Health (NIPH), Oslo, Norway.

IntroductionDuring summer 2016, Norway observed an increase in subsp. serovar Chester cases among travellers to Greece.AimOur aim was to investigate genetic relatedness of Chester for surveillance and outbreak detection by core genome multilocus sequence typing (cgMLST) and compare the results to genome mapping. Read More

Front Immunol 2018 14;9:3149. Epub 2019 Jan 14.

AgroSup Dijon, PAM UMR A 02.102, University Bourgogne Franche-Comté, Dijon, France.

Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response. Several infectious and immune disorders are associated with autophagy defects, suggesting that stimulation of autophagy in these diseases should be beneficial. Here, we show that resveratrol is able to boost xenophagy, a selective form of autophagy that target invasive bacteria. Read More

Front Microbiol 2018 14;9:3329. Epub 2019 Jan 14.

Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

YfdX is a prokaryotic protein encoded by several pathogenic bacteria including serovar Typhi, which causes one of the most fatal infectious diseases, typhoid fever. YfdX is a product of the operon and is known to be under the control of EvgA, a regulator protein controlling the expression of several proteins involved in response to environmental stress, in . Nevertheless, unlike other proteins encoded by the same operon, the structural and physiological aspects of YfdX have been poorly characterized. Read More

Poult Sci 2019 Jan 25. Epub 2019 Jan 25.

Departamento de Producción Animal, Instituto Nacional de Tecnología Agropecuaria (INTA), Estación Experimental Agropecuaria (EEA) Balcarce, RN 226 Km 73.3, (07620) Balcarce, Buenos Aires, Argentina.

Salmonellosis caused by Salmonella Enteritidis is a widespread zoonosis and poultry products are an important source of infection. This study was carried out to evaluate the protection of different vaccination schedules in layers using a live commercial attenuated Salmonella Enteritidis vaccine based on strain Sm24/Rif12/Ssq (AviPro® Salmonella Vac E, ELANCO) during rearing and egg production. Three hundred and fifty Salmonella-free chickens were distributed into 7 vaccinated groups and 1 unvaccinated group. Read More

J Food Prot 2019 Feb;82(2):339-343

2 Division of Environmental Health Sciences, School of Public Health, University of Minnesota, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA.

Restaurants are a frequent setting for outbreaks and sporadic cases of Salmonella. The relationship among food safety management characteristics, compliance with procedures to reduce Salmonella-associated risk factors (as found during routine inspections), and the likelihood that an establishment has experienced a sporadic Salmonella case was assessed. Individual risk factor violations associated with Salmonella transmission pathways were identified by a literature review. Read More

Front Cell Dev Biol 2018 9;6:176. Epub 2019 Jan 9.

Cell Biology of Viral Infection Lab, Instituto Gulbenkian de Ciência, Oeiras, Portugal.

This year marks the 100th anniversary of one of the deadliest pandemic outbreaks, commonly referred as the Spanish Flu, that was caused by influenza A virus (IAV). Since then, IAV has been in governmental agendas worldwide, and a lot of effort has been put into understanding the pathogen's lifecycle, predict and mitigate the emergence of the strains that provoke yearly epidemics and pandemic events. Despite decades of research and seminal contributions there is still a lot to be investigated. Read More

Front Microbiol 2018 9;9:3182. Epub 2019 Jan 9.

National Institute for Public Health and the Environment, Bilthoven, Netherlands.

The increased availability of whole-genome-sequencing techniques generates a wealth of DNA data on numerous organisms, including foodborne pathogens such as . However, how these data can be used to improve microbial risk assessment and understanding of epidemiology remains a challenge. The aim of this study was to assess variability in virulence and genetic characteristics between and within different serovars. Read More