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Am J Clin Pathol 2019 Mar 10. Epub 2019 Mar 10.

Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Objectives: Multi-institutional studies are required for the validation of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC).

Methods: A total of 1,560 fine-needle aspirations of the salivary glands were retrieved from two institutions for a 12-year period. The diagnoses were reclassified based on the MSRSGC. Read More

JFMS Open Rep 2019 Jan-Jun;5(1):2055116919833249. Epub 2019 Feb 26.

University of Toulouse, ENVT, Toulouse, France.

Case Summary: A 1-year-old male neutered cat was presented with a right-sided swelling of the floor of the oral cavity, causing dysphagia and hypersialorrhoea for 2 months. Fine-needle aspiration of the mass and CT were suggestive of a right sublingual sialocoele with no obvious cause. Surgical resection of the ipsilateral sublingual-mandibular salivary gland complex, as well as marsupialisation of the mucocoele, was performed. Read More

Diagn Cytopathol 2019 Feb 27. Epub 2019 Feb 27.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.

Background: Basal cell adenoma (BCA) of the salivary gland is a relatively rare benign tumor. Although the presence of stromal spindle cells is a characteristic histopathological feature, this finding has not been the focus of much attention in the cytodiagnosis of BCA. Thus, we analyzed the cytological features of BCA, especially the presence of stromal spindle cells. Read More

Iran J Otorhinolaryngol 2019 Jan;31(102):45-50

Department of Otorhinolaryngology, Seth G.S Medical College and KEM Hospital, Mumbai, India.

Introduction: Involvement of the salivary glands in tuberculosis is rare, even in countries where tuberculosis is endemic. It can occur by systemic dissemination from a distant focus or, less commonly, as primary involvement. This article focuses on its myriad clinical presentations that pose a diagnostic challenge to the clinician. Read More

Oral Dis 2019 Feb 18. Epub 2019 Feb 18.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Objective: Necrotizing sialometaplasia (NS) is an uncommon benign process which affects minor and, more rarely, major salivary glands. While self-limiting, the condition might be clinically and histologically mistaken for malignancy. Furthermore, NS may accompany neoplasms. Read More

Medicina (B Aires) 2019 ;79(1):64-66

Servicio de Cirugía General, Hospital Alemán, Buenos Aires, Argentina.

Pleomorphic adenoma is the most benign tumor of the salivary glands. It can undergo a malignant transformation to carcinoma and metastasize to distant organs, sometimes it can metastasize as a benign tumor. We present the case of an 82 years old male with hepatic lesion detected by ultrasound in routine urologic follow-up. Read More

Otolaryngol Pol 2018 Sep;72(6):23-30

Collegium Medicum Uniwersytetu Mikołaja Kopernika w Toruniu Klinika Otolaryngologii i Laryngologii Onkologicznej z Pododdziałem Audiologii i Foniatrii.

Introduction Warthin's tumor is a non-malignant tumor that occurs in major salivary glands. Diagnostics include an interview and physical examination as well as additional tests - ultrasonography, magnetic resonance tomography, fine-needle aspiration biopsy. Surgical tumor resection remains the method of treatment, the scope of which includes techniques from extracapsular tumor resection to a full range of parotidectomy. Read More

Adv Anat Pathol 2019 Mar;26(2):84-92

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Fine needle aspiration (FNA) is a well-established procedure for the diagnosis and management of salivary gland lesions despite challenges imposed by their diversity, complexity, and cytomorphologic overlap. Until recently, the reporting of salivary gland FNA specimens was inconsistent among different institutions throughout the world, leading to diagnostic confusion among pathologists and clinicians. In 2015, an international group of pathologists initiated the development of an evidence-based tiered classification system for reporting salivary gland FNA specimens designated the "Milan System for Reporting Salivary Gland Cytopathology" (MSRSGC) that culminated with the publication of the MSRSGC Atlas in February 2018. Read More

Postgrad Med 2018 Dec 17:1-5. Epub 2018 Dec 17.

a Department of Otorhinolaryngology/Head & Neck Surgery , Hamamatsu University School of Medicine , Hamamatsu , Japan.

Background: Fine-needle aspiration (FNA) cytology is frequently used for initial and/or preoperative diagnosis of tumors in the head and neck region. However, false-negative results can lead to misdiagnosis. The aim of this study was to investigate the diagnostic results of FNA in the head and neck region and the reasons for false-negative cases. Read More

Cytopathology 2018 Dec 1. Epub 2018 Dec 1.

Department of Pathology, Truman Medical Center, University of Missouri at Kansas City, Kansas City, Missouri, USA.

Mammary analogue secretory carcinoma of the salivary glands has morphological shares molecular similarities to secretory carcinoma of the breast. Here, we report a 46-year-old woman who presented with a right submandibular gland mass. Fine needle aspiration differential diagnosis included oncocytosis, oncocytoma, acinic cell carcinoma and mammary analogue secretory carcinoma. Read More

Diagn Cytopathol 2018 Nov 29. Epub 2018 Nov 29.

Faculté de Médecine de Tunis, Université de Tunis El Manar, UR17ES15, Tunis, Tunisie.

Background: Head and neck masses are a common presentation in daily practice and can be challenging to both clinicians and cytopathologists. Fine needle aspiration cytology (FNAC) is a widely used method for the diagnosis of head and neck masses. The aim of the study was to assess our institutional experience of the accuracy of FNAC in the diagnosis of head and neck masses. Read More

J Otolaryngol Head Neck Surg 2018 Nov 16;47(1):69. Epub 2018 Nov 16.

Division of Otolaryngology - Head & Neck Surgery, Department of Surgery, Dalhousie University, 5820 University Ave. 3rd Floor Dickson Bldg, Halifax, NS, B3H 2Y9, Canada.

Background: Secretory Carcinoma (SC) is a recently described malignancy affecting salivary glands of the head and neck, with a paucity of evidence regarding the natural history, morbidity, and mortality. This study aimed to investigate the current treatment options utilized for SC, as well as its presentation and outcomes.

Methods: This study is a retrospective case series and includes patients diagnosed with SC at four Maritime Canadian institutions. Read More

Praxis (Bern 1994) 2018 Nov;107(23):1295-1297

1 HNO-Klinik, Universitätsspital Basel.

Diagn Cytopathol 2019 Feb 29;47(2):67-87. Epub 2018 Oct 29.

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania.

Introduction: Fine needle aspiration (FNA) has been widely utilized in establishing the nature of salivary gland lesions and guiding the clinical management. This study aimed to determine the accuracy of FNA in detecting salivary gland neoplasms and malignancies, employing the "Milan System for Reporting Salivary Gland Cytopathology" (MSRSGC).

Method: A systematic search was conducted. Read More

Open Dent J 2018 28;12:782-790. Epub 2018 Sep 28.

Department of Pathology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India.

Objective: Fine Needle Aspiration Cytology (FNAC) is a rapid, reliable and safe diagnostic tool used for various lesions of the oral cavity and salivary glands. The present study was undertaken to categorize the cytomorphology of the oral cavity and salivary gland lesions on FNAC and to assess the accuracy of FNAC in arriving at a diagnosis.

Materials And Methods: A prospective study on oral cavity swellings and salivary gland aspirates was done during a 2 year period from August 2015 to July 2017 in which a total of 70 FNAC's were performed. Read More

Diagn Cytopathol 2018 Oct;46(10):859-863

Unit of Molecular Pathology, IPATIMUP, Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal.

Background: Recently a new system for reporting salivary gland fine-needle aspiration (FNA) cytology was proposed, the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). Herein, we evaluated diagnostic accuracy of salivary gland FNA, comparing the system previously used in our hospital with the Milan system.

Methods: Salivary gland specimens obtained between 2011 and 2017 were reclassified according to MSRSGC. Read More

Diagn Cytopathol 2018 Dec 3;46(12):1004-1009. Epub 2018 Oct 3.

Department of Pulmonary Medicine, Government Medical College and Hospital, Chandigarh, India.

Background: Adenoid cystic carcinoma (ACC) arises at sites where seromucinous or sweat gland epithelium is present and commonly affects the salivary glands. Rarely it can occur at extra-salivary locations.

Methods: A retrospective analysis of 19 cases of ACC diagnosed on fine needle aspiration cytology (FNAC) over a period of 15 y (2002-2016) was made. Read More

Eur Arch Otorhinolaryngol 2018 Nov 20;275(11):2609-2613. Epub 2018 Sep 20.

International Head and Neck Scientific Group, Padua, Italy.

A preoperative cytologic or histologic diagnosis of parotid gland neoplasms is mandatory to decide which surgical procedure would be appropriate. Open biopsies are contraindicated because of the risk of recurrence secondary to tumour cell seeding; furthermore a subsequent curative parotid surgery can be complicated by a previous open biopsy. While fine-needle aspiration cytology (FNAC) was the only preoperative diagnostic procedure to distinguish benign versus malignant neoplasms over the past decades, core needle biopsy (CNB) has been increasingly used over the last few years. Read More

Diagn Cytopathol 2018 Nov 19;46(11):964-965. Epub 2018 Sep 19.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, South Korea.

The case of a fine-needle aspiration biopsy (FNAB) of the patient's salivary gland lesions is considered a rapid, simple, reliable, minimal invasive procedure with markedly rare complications. Herein, we report a case of bleeding from the region of the Wharton's duct after a procedure of a FNAB on the patient's submandibular gland. To our knowledge, this is the first case of bleeding from a salivary duct after a FNAB. Read More

Acta Cytol 2018 17;62(5-6):352-359. Epub 2018 Sep 17.

Objective: To compare the recently proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) with the four-tiered reporting system (FTRS) followed at our institute.

Methods: Parotid gland fine-needle aspirates reported over a period of 5 years were analysed. These aspirates had been placed into 4 categories according to the FTRS: unsatisfactory (UNS), no evidence of malignancy/negative (NEG), inconclusive for malignancy (INC), and diagnostic for malignancy/positive (POS). Read More

Surg Pathol Clin 2018 Sep;11(3):489-500

Department of Pathology, UVA Hospital, University of Virginia, MC 800214, Jefferson Park Avenue, Charlottesville, VA 22908, USA. Electronic address:

Salivary gland fine needle aspiration biopsies remain common specimens seen by most cytology services. The diagnostic diversity and overlap between many of the lesions seen with these biopsies impart many challenges for the cytopathologist, rendering most specific diagnoses impossible with cytology alone. Here, the use of the Milan System for the classification of salivary gland fine needle aspiration biopsy FNAB is discussed, together with the potential use of ancillary testing in arriving at definitive diagnoses. Read More

APMIS 2018 Sep;126(9):771-776

Laboratory of Pathology, Department of Translational Medicine, UPO School of Medicine, Novara, Italy.

Intraductal carcinoma of the salivary glands is a rare, not well-characterized tumor. We reviewed the literature and report the first case of a high-grade unicystic intraductal carcinoma of the parotid. Formalin-fixed/paraffin-embedded blocks were sectioned and stained for hematoxylin and eosin and immunostains (CAM5. Read More

Diagn Pathol 2018 Aug 28;13(1):65. Epub 2018 Aug 28.

Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.

Background: Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating pilomatricoma is a rare variant of pilomatricoma that can rapidly increase and may be misidentified as a malignant tumor. We herein report the cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant parotid tumor. Read More

Acta Cytol 2018 25;62(5-6):346-351. Epub 2018 Jul 25.

Objective: Basal cell adenoma (BCA) is an uncommon benign epithelial neoplasm of salivary glands, which was first described by Kleinsasser and Klein in 1967 and which derives its name from the monomorphic basaloid appearance of tumor cells. This tumor represents 1-2% of all salivary gland epithelial tumors; the most common site of occurrence is the parotid gland. It usually arises in adults over 50 years of age with slight female prevalence. Read More

Cureus 2018 May 18;10(5):e2644. Epub 2018 May 18.

General Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IND.

Cystic lymphangioma of the parotid gland is an uncommon congenital lymphatic malformation. Its occurrence in patients of advanced age is infrequent. Patients usually present with painless soft swelling, often having experienced a long duration of symptoms. Read More

Indian J Dent Res 2018 May-Jun;29(3):396-399

Department of General Pathology, Government Dental College, Kozhikode, Kerala, India.

Papillary cystadenocarcinoma of the salivary gland is a rare malignant tumor and occurs in major and minor salivary glands. Papillary cystadenocarcinoma of the mandible is exceptionally rare. It is usually a low-grade destructive tumor with a papillary and cystic architecture. Read More

Clin Nucl Med 2018 Aug;43(8):593-594

From the Nuclear Medicine and Molecular Imaging Unit, Veneto Institute of Oncology (IOV), Istituto di Ricovero e Cura a Carattere Scientifico, Padua, Italy.

A 65-year-old man with prostate cancer surgically treated in June 2016 underwent F-choline PET/CT in April 2017 for a biochemical recurrence of disease. PET/CT revealed a high tracer uptake in a solid nodulation near the left masseter muscle with a high SUVmax. The patient underwent both ultrasonography examination and fine needle aspiration cytology that confirmed the presence of an ectopic salivary gland. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Mar;32(5):341-344

Department of OtorhinolaryngologyHead and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.

To investigate the clinical features, diagnosis and treatment experience of basal cell adenoma (BCA).The clinical data of 7 patients with basal cell adenoma of the parotid gland from the Second Affiliated Hospital of Medical University of Anhui from March 2012 to June 2016 were retrospectively analyzed. Combined with literature review, the experience of diagnosis and treatment was discussed. Read More

BMC Ear Nose Throat Disord 2018 9;18. Epub 2018 May 9.

Department of Pathology, Seth GSMC & KEMH, Parel, Mumbai, Maharashtra 4900012 India.

Background: Adenoid cystic carcinoma (ACC), a rare tumor of epithelial cell origin, commonly arises from the major salivary glands. Uncommonly it may be found outside the salivary glands and it's especially rare in the nasal cavity.

Case Presentation: A 71-year female had complaints of swelling at the base of nose, Fine needle aspiration (FNA) from the swelling revealed features of adenoid cystic carcinoma; cell block & IHC for CD-117 was positive. Read More

Diagn Cytopathol 2018 Sep 16;46(9):764-768. Epub 2018 Apr 16.

Department of Pathology, Institut Curie, Paris, France.

Medullary thyroid carcinoma occurs in a sporadic setting and may also be inherited in an autosomal dominant fashion, which is related with germline mutations of the RET gene. Metastases are often present at the time of a diagnosis-most frequently within the cervical lymph nodes, followed by the liver, lungs, and bones. Intraocular metastases are extremely rare. Read More

Am J Otolaryngol 2018 May - Jun;39(3):286-289. Epub 2018 Mar 2.

Division of Head and Neck Surgery, Department of Surgery, United Christian Hospital, Hong Kong Special Administrative Region.

Purpose: Benign parotid tumors are adequately treated with partial parotidectomy, which is often performed under general anesthesia (GA). We have reported our preliminary results on the feasibility to perform parotidectomy under local anesthesia (LA). We hereby present our accumulated experience of partial parotidectomy under LA to further consolidate its feasibility, efficacy and safety in a larger series. Read More

Head Neck Pathol 2018 Dec 9;12(4):548-561. Epub 2018 Mar 9.

Division of Anatomic Pathology and Histology, Agostino Gemelli School of Medicine, Catholic University of Sacred Heart, Rome, Italy.

Fine needle aspiration (FNA) has diagnostic and therapeutic value in the management of salivary gland cysts. Rendering an accurate diagnosis from an aspirated salivary gland cyst is challenging because of the broad differential diagnosis, possibility of sampling error, frequent hypocellularity of specimens, morphologic heterogeneity, and overlapping cytomorphology of many cystic entities. To date, there have been no comprehensive review articles providing a practical diagnostic approach to FNA of cystic lesions of salivary glands. Read More

Diagn Cytopathol 2018 Mar 1. Epub 2018 Mar 1.

Department of Pathology, Institute Curie, Paris, France.

Basal cell adenocarcinoma (BCAC) of salivary glands is uncommon low-grade malignancy. Only 19 cases of preoperative cytology were reported up to date. We present here a new case of BCAC arising in the minor salivary gland. Read More

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S54-S56

Department of Conservative Dentistry and Endodontics, Goa Dental College and Hospital, Bambolim, Goa, India.

Adenoid cystic carcinomas are rare epithelial malignancies of salivary glands that show slow growth and local invasion with recurrences seen many years after diagnosis. Upto 50% of tumors occur in intraoral minor salivary glands usually in the hard palate. Tumors on the alveolar mucosa are extremely rare. Read More

J Appl Oral Sci 2018 22;26:e20170267. Epub 2018 Feb 22.

Mures County Emergency Clinic, Department of Oral and Maxillofacial Surgery, University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania.

Salivary gland tumors are relatively rare neoplasms, mostly located in the parotid gland, and few are malignant. Preoperative evaluation of salivary gland tumors includes fine needle aspiration cytology (FNAC).

Objective: The purpose of this study was to determine the importance of FNAC in the evaluation of rare salivary gland neoplasms. Read More

Pathologica 2017 Dec;109(4):355-362

Otorhinolaryngology Unit, "A. Murri" Hospital, Fermo, Italy.

Background: Fine Needle Aspiration Cytology (FNAC) is a well established and widely used method for both a preliminary and sometime final non-invasive pathologic diagnosis. FNAC is a simple and inexpensive diagnostic tool and should represent the standard of care in developing and resource-poor countries while maintaining its diagnostic usefulness in developed and advanced ones.

Methods: The concordance between preoperative FNAC and final histology was evaluated in 168 patients operated on at the Otorhinolaryngology Unit, "A. Read More

Indian J Dent Res 2018 Jan-Feb;29(1):93-106

Department of Oral Pathology and Microbiology, SVS Institute of Dental Sciences, Mahabubnagar, Telangana, India.

To evaluate the diagnostic accuracy of fine-needle aspirations (FNAs) in salivary gland pathologies. A comprehensive literature search was conducted in the PubMed database using related Medical Subject Heading terms "sensitivity and specificity of FNA in salivary gland" and "diagnostic accuracy of FNA in salivary gland" for the period 1980-2016, and we found that 414 research studies had been published. PRISMA technology was utilized to prepare flow chart for displaying data search strategy. Read More

Am J Otolaryngol 2018 May - Jun;39(3):345-348. Epub 2018 Feb 1.

Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai Hospital, Mount Sinai Beth Israel, 10 Union Square East, Suite 5B, New York, NY 10003, USA.

Background: Leiomyosarcoma of the head and neck region is very rare. Primary parotid leiomyosarcoma has only been reported nine times in the medical literature.

Methods: A 68-year-old female presented with a left facial mass. Read More

J Pathol Transl Med 2018 Mar 28;52(2):136-139. Epub 2017 Dec 28.

Deparment of pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea.

Carcinosarcoma of the salivary gland is an extremely rare tumor that is composed of both malignant epithelial and mesenchymal components. Diagnosing carcinosarcoma with fine-needle aspiration cytology is challenging because of its overlapping cytomorphologic characteristics with other high-grade malignant salivary gland tumors. Among the many features, including pleomorphic oncocytoid epithelial components, necrotic background, and mitoses, recognizing the singly scattered atypical spindle cells is most essential in carcinosarcoma. Read More

Cancer Cytopathol 2018 Apr 20;126(4):275-281. Epub 2017 Dec 20.

Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Polymorphous adenocarcinoma (PAC) of the palatal minor salivary glands, previously known as polymorphous low-grade adenocarcinoma, is the second most common intraoral malignant salivary gland carcinoma after adenoid cystic carcinoma (ACC) and carries an excellent prognosis. Unfortunately, PAC demonstrates cytological overlap with 2 other salivary gland tumors frequently encountered in the same location, namely ACC and pleomorphic adenoma (PA). Recently, the protein kinase D1 (PRKD1) hotspot mutation E710D was demonstrated to be specific for PAC and to be present in the majority of cases. Read More

Am J Otolaryngol 2018 Mar - Apr;39(2):162-166. Epub 2017 Nov 29.

Department of Otolaryngology, Head and Neck Surgery, Whangarei Base Hospital, Northland, New Zealand.

Background: The surgical management of benign parotid tumors is aimed at complete extirpation of the mass with preservation of facial nerve function. There is a relative paucity of literature pertaining to complications after benign parotid surgery and related risk factors. We aim to critically review the outcomes following treatment of benign parotid pathology when surgery entailed either complete superficial parotidectomy (CSP), partial superficial parotidectomy (PSP) or extracapsular dissection (ECD). Read More

Dentomaxillofac Radiol 2018 May 10;47(4):20170331. Epub 2018 Jan 10.

1 Department of Oral Pathology, Radiology and Medicine,College of Dentistry, The University of Iowa , Iowa City, IA , USA.

Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. The submandibular gland is rarely involved, about less than 10% of all other major salivary glands. We report a case of a 49-year-old female who presented with a mass on the left side of the floor of the mouth. Read More

Diagn Cytopathol 2018 May 4;46(5):429-433. Epub 2017 Dec 4.

Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan.

Salivary duct carcinoma (SDC) is an aggressive form of salivary gland tumor, and SDC patients tend to be older men, more commonly in advanced stage with a poorer prognosis. Although the cytological characteristics of SDC on fine-needle aspiration cytology have been well-described at the primary site, they have not been explored in metastasis. Here we reported a case of HER2/HER3-positive metastatic SDC in the lung and pleural effusion. Read More

Tumori 2017 Nov 1:tj5000690. Epub 2017 Nov 1.

1 Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy.

Introduction Signet-ring cell (SRC) carcinoma is a common subtype of gastric adenocarcinoma associated with poor prognosis. Metastatic involvement of the parotid gland has been reported in gastric cancer patients, but never bilaterally nor in association with the SRC histotype. Here, we report the first case and a brief review of the literature. Read More

Ann Ital Chir 2017 Nov 14;6. Epub 2017 Nov 14.

Aim: This report shows an incidental finding of Warthin tumor in upper lip mucosa during hospitalization for a biting lesion of cheek mucosa MATERIALS AND METHODS: A 32-year-old male affected by a biting lesion of cheek mucosa was presented at Maxillo- Facial Unit of Federico II University. Clinical examination showed as an incidental finding a solid mass in the superficial layer of upper lip mucosa. We performed mini-invasive surgical treatment to obtain a radical excision of the cheek lesion at the same time as excision of Warthin tumor. Read More

Cancer Cytopathol 2018 02 13;126(2):101-111. Epub 2017 Nov 13.

Division of Cytopathology, Pathology Department, The Johns Hopkins Hospital, Baltimore, Maryland.

Background: Fine-needle aspiration (FNA) is routinely performed to evaluate salivary gland lesions, and provides valuable information regarding the cytomorphologic features of the lesions. Occasionally, there are overlaps between benign and malignant conditions due to heterogeneity of the cell types, metaplastic changes, and sampling issues. Herein, the authors present a retrospective study of diagnostic pitfalls in salivary gland cytology and the simulating conditions. Read More

Head Neck 2018 Jan 30;40(1):154-162. Epub 2017 Oct 30.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: In the absence of unified treatment protocol, we evaluated the management and outcomes of submandibular gland cancers in an unselected patient series.

Methods: We included all patients with resected submandibular gland cancer treated at the Helsinki University Hospital from 2000 to 2010 with a 5-year minimum follow-up.

Results: Twenty-five patients with cancer represented 30% of submandibular gland neoplasms, and most were adenoid cystic carcinomas (ACCs; 56%). Read More

Cancer Cytopathol 2018 02 20;126(2):94-100. Epub 2017 Oct 20.

Department of Laboratory Medicine and Pathology, Temple University Hospital, Philadelphia, Pennsylvania.

Background: Fine-needle aspiration (FNA) cytology is well accepted as a safe, reliable, minimally invasive, and cost-effective method for the diagnosis of salivary gland lesions. Salivary gland neoplasms are often difficult to diagnose because of morphologic heterogeneity and a variety of epithelial metaplastic changes. Hence, a number of salivary gland FNA specimens yield indeterminate results. Read More

J Maxillofac Oral Surg 2017 Dec 8;16(4):500-505. Epub 2015 May 8.

Department of Oral and Maxillofacial Surgery, S D Dental College and Hospital, Parbhani, Maharashtra India.

Salivary gland tumours constitute about less than 4 % of all head and neck tumours. Pleomorphic adenoma, also called benign mixed tumour, is the most common tumour of the salivary glands. About 80-90 % of these tumours occur in the major salivary glands mainly parotid gland and 10 % of them occur in the minor salivary glands. Read More

Diagn Cytopathol 2018 Mar 16;46(3):263-266. Epub 2017 Oct 16.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21224.

Adamantinoma-like Ewing sarcoma (AES) is a rare variant of Ewing sarcoma family of tumors (EFTs), primarily affecting bone and soft tissue. AES has mixed features of Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) and adamantinoma with a complex immunoprofile and EWSR1 gene rearrangements. Herein, we report a 72-year-old male who presented with left parotid mass, right neck mass and thyroid nodules. Read More