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Front Endocrinol (Lausanne) 2021 7;12:654638. Epub 2021 Apr 7.

Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, China.

There are many histological morphological types of papillary thyroid carcinoma (PTC), but the most frequently seen types are conventional. A single PTC commonly has a conventional and/or a variant morphological pattern. PTC with multiple (more than two) well-differentiated morphological patterns are extremely rare. Read More

Natl J Maxillofac Surg 2020 Jul-Dec;11(2):289-291. Epub 2020 Dec 16.

Department of Hospital Administration, District Hospital Baramulla, Baramulla, Jammu and Kashmir, India.

Pleomorphic adenoma (PA), also called mixed tumor, is the most common benign tumor of the salivary glands that mostly occurs in the parotid or submandibular glands but may also occur in the minor salivary glands that are distributed throughout the oral cavity. The common sites of PA of the minor salivary glands are the palates followed by lips and cheeks. Surgical removal with adequate margins is the principal treatment. Read More

Eur J Radiol 2021 Apr 10;139:109716. Epub 2021 Apr 10.

Department of Experimental and Clinical Biomedical Sciences, Radiodiagnostic Unit n. 2, Careggi University Hospital, Largo Brambilla 3, Florence, 50134, Italy. Electronic address:

Salivary gland tumours are rare, representing only 3% of all head and neck neoplasms, with the parotid gland being the most common site (80 %). The risk of malignancy is inversely proportional to the size of the gland: lesions arising in the sublingual or minor salivary glands are more likely to be malignant, whereas parotid gland neoplasms are mostly benign. Fine needle aspiration cytology and core needle biopsy are considered the most accurate modalities for the diagnosis of a salivary gland neoplasm; however, they are not always conclusive due to procedural sampling errors and for the presence of a cytological / histological overlap between benign and malignant tumours. Read More

Eur Arch Otorhinolaryngol 2021 Mar 19. Epub 2021 Mar 19.

Department of Otorhinolaryngology - Head and Neck Surgery, Inselspital, Bern University Hospital, Freiburgstrasse, 3010, Bern, Switzerland.

Purpose: Parapharyngeal space neoplasms (PSNs) are rare tumors of the head and neck region. In this study, we report our institutional experience with PSNs over a 27-years period.

Methods: Patients treated between 1992 and 2018 were identified through our tumor board database. Read More

J Int Med Res 2021 Mar;49(3):300060521997592

Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Hepatocellular carcinoma (HCC), the most common primary hepatic tumor, metastasizes in more than 50% of cases. However, metastasis of HCC to the submandibular glands is very rare. HCC rarely metastasizes to the salivary glands; only six cases of metastasis to the parotid gland have been reported in the English-language literature. Read More

J Am Soc Cytopathol 2021 Feb 22. Epub 2021 Feb 22.

Department of Cytopathology, Alpha Prolipsis Medical Laboratories, Athens, Greece.

Objective: The objective of this study was to investigate the feasibility of implementing videos captured by static telecytological applications for remote cytological diagnosis of fine needle aspiration (FNA) specimens from salivary gland lesions.

Methods: The current study was performed on 102 specimens from patients referred to the Alpha Prolipsis Cytopathology Department for preoperative evaluation of salivary gland lesions. In all cases, surgical excision followed the initial cytological diagnosis. Read More

Niger Postgrad Med J 2021 Jan-Mar;28(1):27-32

Department of Oral and Maxillofacial Surgery, Aminu Kano Teaching Hospital, Kano, Nigeria.

Background: Neoplasms both benign and malignant are the most common indications for parotidectomy. About 70%-80% of all salivary gland tumours are located in the parotid gland with up to 80% being benign. Parotidectomy is a common surgical procedure performed by the otorhinolaryngologist and oral and maxillofacial surgeons. Read More

Int J Oral Maxillofac Surg 2021 Feb 19. Epub 2021 Feb 19.

Showa University Head and Neck Oncology Centre, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, Division of Oral Oncology, Showa University, School of Dentistry, Tokyo, Japan; Department of Otorhinolaryngology, Showa University, School of Medicine, Tokyo, Japan.

The objective of this study was to investigate the accuracy of fine needle aspiration cytology (FNAC) and biopsy for the clinical diagnosis of minor salivary gland tumours (MSGTs). This retrospective study of 32 MSGT cases was conducted over a 5-year period. Clinical features including age, sex, and location of the tumour were obtained from the patient clinical records. Read More

J Telemed Telecare 2021 Feb 17:1357633X21995061. Epub 2021 Feb 17.

Department of Cytopathology, Alpha Prolipsis Medical Laboratories, Athens, Greece.

Objective: The objective of this study was to examine the feasibility of implementing videos captured by static telecytological applications for remote cytological evaluation of fine needle aspiration specimens from salivary gland lesions.

Methods: The current study was carried out on 102 fine needle aspiration specimens from salivary gland lesions with histological confirmation (benign lesions, 11; benign neoplasms, 68; malignant neoplasms, 23), retrospectively selected from the department's registry. Videos were transferred via file transfer protocol to password-protected accounts for remote review by three independent cytopathologists. Read More

J Pak Med Assoc 2021 Jan;71(1(A)):153-155

Department of General Surgery, Lahore General hospital, Lahore, Pakistan.

Lipomas in the submandibular region are very uncommon. Large submandibular neck mass (greater than 10 cm) with a rapid growth rate, may raise concern about possible malignancy of salivary glands. Failure to distinguish salivary gland tumour and liposarcoma from a lipoma may represent a medico-legal pitfall. Read More

Am J Otolaryngol 2021 May-Jun;42(3):102924. Epub 2021 Jan 13.

Department of Otolaryngology - Head and Neck Surgery, University of Missouri School of Medicine, Columbia, MO, USA.

Objectives: To report a unique case of salivary duct cyst presenting as parapharyngeal space mass and review relevant literature regarding salivary duct cyst and fine needle aspiration biopsy of salivary gland lesions.

Methods: After a case description, a review of the literature regarding salivary duct cyst etiology, pathophysiology, presentation, histologic features, and the accuracy of FNA in the context of salivary gland lesions was conducted.

Results: Salivary duct cysts are rare, often acquired, cystic dilatations of salivary ducts thought to arise secondary to ductal obstruction, commonly occurring in the major salivary glands. Read More

Head Neck Pathol 2021 Jan 18. Epub 2021 Jan 18.

Department of Cytopathology, Alpha Prolipsis Medical Laboratories, 163 Mesogion Street, 11526, Athens, Greece.

This study aimed to present the 2-year experience of the implementation of the Milan System for Reporting Salivary Gland Cytopathology at Alpha Prolipsis Medical Laboratories, a private medical laboratory located in Athens, Greece. A totaI of 102 Fine Needle Aspirations (FNAs) performed since 2018 were included in the study. Reports were issued according to the Milan System for Reporting Salivary Gland Cytopathology. Read More

Acta Cytol 2021;65(2):194-196. Epub 2021 Jan 5.

Istituto Cantonale di Patologia, Locarno, Switzerland,

Cureus 2020 Nov 17;12(11):e11528. Epub 2020 Nov 17.

Otolaryngology - Facial Plastic Surgery, Beaumont Health-Farmington Hills, Farmington Hills, USA.

Primary lymphomas of the salivary glands are rare tumors seen in the head and neck. We report the case of a 52-year-old woman with an extranodal marginal cell lymphoma of her submandibular gland, whose primary presenting symptom was a slow swelling of her neck. Fine-needle aspiration of the mass was performed, followed by CT imaging studies, and both tests showed inconclusive results. Read More

Oman Med J 2020 Nov 30;35(6):e209. Epub 2020 Nov 30.

Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Maharashtra, India.

Malignant mesenchymoma is a rare tumor in which there are two or more distinct mesenchymal components. These are generally considered as high-grade neoplasms and are usually associated with a poor prognosis. Here, we report a case of malignant mesenchymoma containing undifferentiated spindle cell sarcoma, leiomyosarcoma, chondrosarcoma, osteosarcoma, and areas with rhabdoid differentiation in a 54-year-old male. Read More

BMJ Case Rep 2020 Nov 30;13(11). Epub 2020 Nov 30.

ENT-Head & Neck Surgery, St George's University Hospital NHS Foundation Trust, London, London, UK

Non-sebaceous lymphadenoma (NSLA) is a rare benign salivary gland tumour with lymphoid and epithelial components and without sebaceous differentiation. The large majority of the reported cases arise within the parotid gland. We present an NSLA arising from the submandibular gland. Read More

Int J Clin Oncol 2021 Feb 20;26(2):326-334. Epub 2020 Nov 20.

Department of Pathology, Osaka Medical College, Takatsuki, Osaka, Japan.

Background: When determining treatment strategy for a salivary gland tumor, assessing histology and malignancy grade before surgery is essential. Several new diagnostic classification systems for salivary gland cytology have recently been proposed. However, none incorporate histology and grade of malignancy. Read More

Ear Nose Throat J 2020 Nov 4:145561320971932. Epub 2020 Nov 4.

Department of Clinical Pathology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Okayama, Japan.

We describe the case of a 51-year-old woman with immunoglobulin G4-related disease (IgG4-RD) diagnosed using lip biopsy. She reported having bilateral submandibular nodules for a month. Magnetic resonance imaging showed diffuse swelling in the bilateral submandibular glands (SMGs), suggesting inflammatory changes. Read More

Acta Cytol 2021 28;65(2):123-131. Epub 2020 Oct 28.

Department of Diagnostic Pathology, Okinawa Red Cross Hospital, Okinawa, Japan.

Objective: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a recently published evidence-based categorization system for salivary gland fine-needle aspiration (FNA). We applied MSRSGC to Japanese cases and evaluated its utility.

Study Design: A total of 480 FNA cases were reviewed. Read More

Cancer Cytopathol 2020 Dec 27;128(12):885-894. Epub 2020 Oct 27.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: To the authors' knowledge, the impact of the coronavirus disease 2019 (COVID-19) pandemic on cytopathology practices worldwide has not been investigated formally. In the current study, data from 41 respondents from 23 countries were reported.

Methods: Data regarding the activity of each cytopathology laboratory during 4 weeks of COVID-19 lockdown were collected and compared with those obtained during the corresponding period in 2019. Read More

Cytopathology 2021 Mar 6;32(2):261-265. Epub 2020 Dec 6.

Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA.

Spindle cell lesions of the salivary glands are rare and account for less than 3% of the salivary gland aspirates. A definitive classification of salivary gland neoplasms by fine needle aspiration is possible for the most common lesions but remains a challenge for the less common entities. We present a case of a 72-year-old male with a solitary fibrous tumour (SFT) of the submandibular gland mimicking a myoepithelial-rich pleomorphic adenoma (PA). Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2020 Oct 12. Epub 2020 Oct 12.

Service d'ORL et de chirurgie de la face et du cou, CHU de Lille, Lille, France.

Introduction: The authors present the guidelines of the French Society of Otorhinolaryngology-Head and Neck Surgery (SFORL) for the diagnosis and treatment of pleomorphic adenoma (PA) of the salivary glands.

Method: A review of the literature was performed by a multidisciplinary task force. Guidelines were drafted based on the articles retrieved and the workgroup members' individual experience. Read More

Acta Cytol 2021 12;65(1):27-39. Epub 2020 Oct 12.

Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhubaneswar, India,

Introduction: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was proposed by the American Society of Cytopathology and the International Academy of Cytology to bring uniformity in the reporting system and the treatment protocol. A wide range of risk of malignancy for each category has been reported by various authors by applying the system.

Aim: We intend to study the cytohistological concordance and the ROM for each of the diagnostic categories of the Milan system. Read More

Am J Otolaryngol 2021 Jan - Feb;42(1):102590. Epub 2020 Jun 10.

Sisli Hamidiye Etfal Training and Research Hospital, Department of Ear Nose Throat Head and Neck Surgery, Istanbul, Turkey.

Purpose: Major salivary gland tumors constitute almost 3% of head and neck tumors. Tumors located exclusively in the deep lobe are not common and 20% of parotid gland tumors originate from deep lobe under the branches of the facial nerve. Accuracy of fine needle aspiration biopsy (FNAB) procedure in salivary gland tumors have been studied extensively, however there isn't any data regarding usefulness of FNAB in tumors located exclusively in deep lobe of parotid gland. Read More

BMJ Case Rep 2020 Oct 10;13(10). Epub 2020 Oct 10.

Department of Otolaryngology, Head and Neck surgery, Aberdeen Royal Infirmary, Aberdeen, UK.

The sclerosing variant of mucoepidermoid salivary gland carcinoma is extremely rare. It is nearly impossible to diagnose this condition preoperatively. We present a case of a 23-year-old woman with a 1-year history of left parotid enlargement with inconclusive fine-needle aspiration cytology results. Read More

J Am Vet Med Assoc 2020 Oct;257(8):826-832

Objective: To describe intracanalicular injection of 10% N-acetylcysteine (IINAC) as adjunctive treatment for sialoceles in dogs.

Animals: 25 client-owned dogs.

Procedures: Hard copy medical records at 2 veterinary ophthalmology practices were searched to identify dogs that underwent IINAC for treatment of sialoceles from January 2000 to December 2017. Read More

Diagn Cytopathol 2021 Feb 5;49(2):241-251. Epub 2020 Oct 5.

Pathology, Fimlab Laboratories, Tampere, Finland.

Objective: Fine-needle aspiration (FNA) is a key diagnostic method in the evaluation of salivary gland lesions. Secondary tumors of salivary glands represent only 5% of all malignancies of major salivary glands. The goal of our study was to examine the cytological and clinical features of secondary tumors sampled by FNA. Read More

Diagn Cytopathol 2021 Feb 1;49(2):187-194. Epub 2020 Oct 1.

Department of Pathology and Laboratory Medicine, Eastbourne Disrtrict General Hospital - East Sussex, Healthcare NHS Trust, Kings Drive, Eastbourne, England.

Background: The Milan system for reporting salivary gland cytopathology (MSRSGC) aims to standardize terminology, facilitate communication, and optimize management by providing risk of malignancy (ROM) for each category. Our retrospective cohort aims to study the reproducibility of reporting using the MSRSGC and to calculate the ROM for each category.

Methods: Cases of fine needle aspiration (FNA) of salivary glands and related cervical lymph nodes were retrieved from our files between 2015 to 2019. Read More

Oral Oncol 2021 02 28;113:105026. Epub 2020 Sep 28.

Department of Otolaryngology, Medical University of Gdansk, Poland.

Am J Otolaryngol 2020 Nov - Dec;41(6):102718. Epub 2020 Sep 12.

Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: Usefulness of preoperative tissue sampling and pathology diagnoses in parotid gland tumors were accepted worldwide. We investigate the role of CNB in the parotid gland lesions when FNA results are inconclusive.

Methods: We conducted a cross sectional study to evaluate CNB results from fifty-two patients with history of parotid gland lesion and inconclusive previous fine needle aspiration. Read More