71,326 results match your criteria Salivary Gland Tumors Minor Benign


Salivary Biomarkers of Parenting Stress in Mothers Under Community Criminal Justice Supervision.

Nurs Res 2019 Jan/Feb;68(1):48-56

Jenna K. Rieder, BA, is Research Assistant, The Graduate Center, The City University of New York, NY. Lorie S. Goshin, PhD, RN, is Assistant Professor; and D.R. Gina Sissoko, BA, is Research Assistant, Hunter College, The City University of New York, NY. Olena Kleshchova, MS, is Research Assistant, The Graduate Center, The City University of New York, NY. Mariann R. Weierich, PhD, is Associate Professor, Hunter College, The City University of New York, NY.

Background: Community criminal justice supervised mothers are an underserved population who experience high rates of psychological distress and unique parenting challenges, but little is known about physiological stress system function in this population.

Objective: We tested the salivary biomarkers of the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis function as predictors of subjective maternal stress.

Method: We recruited 23 mothers (age: M = 35. Read More

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December 2018

Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals.

Mol Biol Cell 2018 Dec 12:mbcE18100615. Epub 2018 Dec 12.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr. Rm 2050B, Bethesda, MD, 20892 USA.

Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model systems in vivo. Here we used the salivary glands of live mice to examine the role of the small GTPase Cdc42 in the regulation of the homeostasis of the intercellular canaliculi, a specialized apical domain of the acinar cells, where protein and fluid secretion occur. Read More

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December 2018

Proteomic analysis of the acquired enamel pellicle formed on human and bovine tooth: a study using the Bauru in situ pellicle model (BISPM).

J Appl Oral Sci 2018 Dec 10;27:e20180113. Epub 2018 Dec 10.

Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departmento de Ciências Biológicas, Bauru, SP, Brasil.

Objectives: The acquired enamel pellicle (AEP) is an organic film, bacteria-free, formed in vivo as a result of the selective adsorption of salivary proteins and glycoproteins to the solid surfaces exposed to the oral environment. Objective: This study aimed to compare the proteomic profile of AEP formed in situ on human and bovine enamel using a new intraoral device (Bauru in situ pellicle model - BISPM).

Material And Methods: Material and Methods: One hundred and eight samples of human and bovine enamel were prepared (4×4 mm). Read More

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December 2018

Practice variations in salivary gland imaging and utility of virtual unenhanced dual energy CT images for the detection of major salivary gland stones.

Acta Radiol 2018 Dec 12:284185118817906. Epub 2018 Dec 12.

1 Department of Radiology, Jewish General Hospital & McGill University, Montreal, QC, Canada.

Background: There are variations in computed tomography (CT) protocols used for evaluating sialolithiasis, with some protocols including acquisitions before and after IV contrast administration. Dual-energy CT (DECT) can be used to generate virtual unenhanced (VUE) images, potentially precluding the need for an uninfused scan.

Purpose: In this study, we performed a survey in order to assess variations in the imaging approach for sialolithiasis and evaluated the accuracy of DECT VUE images for the detection of salivary stones. Read More

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December 2018

Determination of Autoantibodies to Salivary Gland Antigens.

Methods Mol Biol 2019 ;1901:103-112

UCLA School of Dentistry, Los Angeles, CA, USA.

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease marked by dry mouth/dry eye symptoms as a result of the destruction of the salivary and lacrimal glands. Patients with pSS may be at risk for the development of mucosa-associated lymphoid tissue (MALT) lymphoma. Testing of autoantibodies in the oral fluid of patients with pSS or MALT lymphoma using immunoassays may lead to a simple and noninvasive clinical tool for diagnostic or prognostic applications. Read More

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January 2019

Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.

Cell Oncol (Dordr) 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 N University Ave, Room 2029C, Ann Arbor, MI, 48109-1078, USA.

Purpose: Emerging evidence indicates that bromodomains comprise a conserved class of epigenome readers involved in cancer development and inflammation. Bromodomains are associated with epigenetic modifications of gene transcription through interactions with lysine residues of histone tails. Particularly, the bromodomain and extra-terminal domain (BET) family member BRD4 has been found to be involved in the control over oncogenes, including c-MYC, and in the maintenance of downstream inflammatory processes. Read More

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December 2018
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Oncocytic Sialolipoma of Parotid Gland: Case Report and Literature Review.

Head Neck Pathol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ear, Nose and Throat, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.

Oncocytic sialolipoma is a very rare tumor of which only three cases have been reported. This entity is considered to be a variant of sialolipoma which harbours oncocytic nodules within a well-circumscribed lipomatous mass. We report a parotid mass in 73-year-old female that was difficult to diagnose in imaging and on biopsy. Read More

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December 2018

Identification of salivary metabolites for oral squamous cell carcinoma and oral epithelial dysplasia screening from persistent suspicious oral mucosal lesions.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.

Objective: To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with persistent suspicious oral mucosal lesions (PSOML).

Subjects And Methods: Whole unstimulated saliva samples were collected from age-, sex-, and race-matched patients who had a lesion in the oral cavity and for whom open biopsies were performed. The patients included OSCC (n = 6), OED (n = 10), and PSOML (n = 32). Read More

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December 2018

Radiotherapy as salvage treatment of salivary duct carcinoma in major salivary glands without radical operations.

Cancer Manag Res 2018 21;10:6071-6078. Epub 2018 Nov 21.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China,

Background: Salivary duct carcinoma (SDC) is an extremely rare and highly malignant carcinoma, and surgical radical resection is the most effective therapy. However, there were quite a proportion of patients receiving non-radical resections, and how to treat them remained controversial. Thus, the aim of this study is to evaluate whether postoperative radiotherapy could be a salvage treatment of SDC in major salivary glands without radical operations. Read More

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November 2018

Role of miRNAs in skeletal muscle aging.

Clin Interv Aging 2018 22;13:2407-2419. Epub 2018 Nov 22.

Department of Geriatrics, The First Hospital of Jilin University, Changchun 130021, Jilin, China,

Purpose: The aim of this study was to explore the role of miRNAs in the process of skeletal muscle aging.

Materials And Methods: We analyzed the miRNA microarray datasets from 19 young and 17 old skeletal muscle samples by bioinformatic analysis. Differentially expressed miRNAs were identified, followed by function and pathway enrichment analysis. Read More

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November 2018

[Value of sialendoscopy in German ENT-hospitals in 2016].

Laryngorhinootologie 2018 Dec 11. Epub 2018 Dec 11.

Universitatsklinikum Giessen und Marburg Standort Giessen HNO.

Objective: In 2009 a nationwide survey revealed that only 24 % of the German ENT-hospitals performed sialendoscopy. In 2016 the survey was repeated to reevaluate the actual ranking of sialendoscopy in Germany.

Material Und Methods: Again, the same questionnaire as in 2009 was sent to all German ENT-hospitals. Read More

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December 2018
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Cortisol Stress Reactivity to the Trier Social Stress Test in Obese Adults.

Obes Facts 2018 Dec 11;11(6):491-500. Epub 2018 Dec 11.

Objective: Approximately 600 million adults worldwide suffer from obesity. In addition to individual's eating behavior and lack of physical activity in the development of obesity and overweight, psychosocial stress as well as hormonal stress reactivity must also be considered as important contributing factors. In the current study we compared the cortisol stress response pathway in a psychosocial stress induction (Trier Social Stress Test; TSST) with obese individuals and normal-weight controls. Read More

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December 2018
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Daily oxytocin patterns in relation to psychopathy and childhood trauma in residential youth.

Psychoneuroendocrinology 2018 Dec 1;102:105-113. Epub 2018 Dec 1.

Behavioural Science Institute, Radboud University, Nijmegen, the Netherlands; Stichting Conrisq Groep, the Netherlands; Stichting Jeugdzorg Sint Joseph, the Netherlands; Maastricht University, the Netherlands.

Inconsistent findings have been found on the relation between oxytocin levels and psychopathy or callous-unemotional (CU) traits in humans, potentially because the role of trauma in oxytocin secretion and the distinction between primary and secondary psychopathy have been overlooked so far. Primary psychopathy has a stronger biological background, whereas secondary psychopathy mainly develops due to environmental adversity, such as childhood trauma. This study investigated the interaction effects of CU traits and childhood trauma on daily salivary oxytocin levels in 57 males living in residential youth care facilities. Read More

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December 2018

Histological and histochemical characterisation of glands associated with the feeding appendages of Argulus foliaceus (Linnaeus, 1758).

Parasitol Int 2018 Dec 8. Epub 2018 Dec 8.

Institute of Aquaculture, University of Stirling, Stirling, UK.

Argulus foliaceus (Linnaeus, 1758) is a member of the branchiuran family Argulidae, a group comprising parasitic "fish lice". A. foliaceus is distributed worldwide and causes major economic impacts for cultured freshwater fish globally. Read More

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December 2018
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Differential Mucosal Gene Expression Patterns in Candida-Associated, Chronic Oral Denture Stomatitis.

J Prosthodont 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY.

Purpose: Denture stomatitis is a common condition manifested by inflammation of the oral mucous membrane beneath a denture. The objective of this study was to compare the transcriptome of human palatal mucosa with chronic oral stomatitis-associated Candida albicans infection to that of healthy oral mucosa.

Materials And Methods: Oral palatal biopsies were obtained from 17 healthy and 15 C. Read More

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December 2018

Gingival crevicular fluid and salivary HIF-1α, VEGF, and TNF-α levels in periodontal health and disease.

J Periodontol 2018 Dec 11. Epub 2018 Dec 11.

Department of Periodontology, Faculty of Dentistry, Ege University, İzmir, Turkey.

Aim: Hypoxia-inducible factor-1 alpha (HIF-1α) is expressed as an adaptive response to hypoxia, mediates angiogenesis through the expression of vascular endothelial growth factor (VEGF) and can be induced by tumor necrosis factor-alpha (TNF-α). This study aimed to investigate the gingival crevicular fluid (GCF) and salivary HIF-1α, VEGF, and TNF-α levels in periodontal health and disease.

Methods: A total of 87 individuals, 20 generalized aggressive periodontitis (G-AgP), 20 chronic periodontitis (CP), 26 gingivitis patients, and 21 periodontally healthy individuals, were included. Read More

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December 2018

Melatonin release by exocytosis in the rat parotid gland.

J Anat 2018 Dec 10. Epub 2018 Dec 10.

Department of Biomedical Sciences, Division of Cytomorphology, University of Cagliari, Cagliari, Italy.

Several beneficial effects on oral health are ascribed to melatonin. Due to its lipophilic nature, non-protein-bound circulating melatonin is usually thought to enter the saliva by passive diffusion through salivary acinar gland cells. Recently, however, using transmission electron microscopy (TEM), melatonin was found in acinar secretory granules of human salivary glands. Read More

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December 2018
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Venous thromboembolism in head and neck surgery: Risk, outcome, and burden at the national level.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Venous thromboembolism (VTE) can complicate major surgeries. This study examines the risk and outcomes of VTE in patients who underwent head and neck surgeries.

Methods: Retrospective cross-sectional analysis utilizing the Nationwide Readmissions Database (2010-2014). Read More

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December 2018
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Evaluation of salivary acetylcholinesterase and pseudocholinesterase in patients with Alzheimer's disease: A case-control study.

Spec Care Dentist 2018 Dec 11. Epub 2018 Dec 11.

Assistant Professor of Linguistics, Department of Persian Literature and English Language, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Aim: The aim of this study was to evaluate acetylcholinesterase (AChE) and pseudocholinesterase (PChE) in whole saliva in patients with Alzheimer's disease (AD) and in healthy subjects. Saliva has a high potential for keeping track of general health and diseases. AD is a type of dementia with reduction in brain cholinergic markers that causes memory, thinking, and behavior problems. Read More

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December 2018

Oral probiotics influence oral and respiratory tract infections in pediatric population: a randomized double-blinded placebo-controlled pilot study.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8034-8041

Department of Clinical and Translational Medicine "Tor Vergata" University of Rome, Rome, Italy.

Objective: Acute oral and respiratory tract infections (RTIs) are highly present in the general population, and they represent one of the most impacting causes of morbidity and mortality every year. The aim of our study was to assess the clinical impact of oral probiotics on acute oral and respiratory tract infections affecting paediatric patients.

Patients And Methods: This is a randomized, double-blinded placebo-controlled clinical study, where probiotics have been compared with placebo in a double-blinded investigation. Read More

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November 2018

Identification of Abnormal Fucosylated-Glycans Recognized by LTL in Saliva of HBV-Induced Chronic Hepatitis, Cirrhosis, and Hepatocellular Carcinoma.

Glycobiology 2018 Dec 7. Epub 2018 Dec 7.

Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi'an, China.

The hepatitis B virus (HBV)-induced chronic liver diseases are serious health threats worldwide. There is evidence to display the alterations of salivary N-linked glycans related to the development of HBV-infected liver diseases. Here, we further investigated the alterations of fucosylated N/O-glycans recognized by LTL in saliva from 120 subjects (30 healthy volunteers (HV), 30 patients with hepatitis B (HB), 30 patients with hepatic cirrhosis (HC), and 30 patients with hepatocellular carcinoma (HCC)) using salivary microarrys and MALDI-TOF/TOF-MS. Read More

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December 2018

Beneficial effect of laughter therapy on physiological and psychological function in elders.

Nurs Open 2019 Jan 18;6(1):93-99. Epub 2018 Jul 18.

Graduate School of Health Sciences Morinomiya University of Medical Sciences Suminoe-ku Japan.

Aim: In the present study we investigated the effect of laughter therapy on physiological and psychological function in older people.

Design: An open-label trial.

Methods: Seventeen older people who regularly attended an elderly day care centre were recruited. Read More

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January 2019
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Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: Biokinetics, Dosimetry, and Evaluation in Patients with Advanced Prostate Cancer.

Contrast Media Mol Imaging 2018 11;2018:5247153. Epub 2018 Nov 11.

Departamento de Medicina Nuclear, Instituto Nacional de Cancerología, Ciudad de México 14000, Mexico.

SPECT/CT images in patients have demonstrated the ability of [Tc]Tc-EDDA/HYNIC-Lys(Nal)-Urea-Glu ([Tc]Tc-iPSMA) to detect tumors and metastases of prostate cancer. Considering that theranostics combines the potential of therapeutic and diagnostic radionuclides in the same molecular probe, the aim of this research was to estimate the biokinetics and dosimetry of Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu (Lu-iPSMA) in healthy subjects and analyze the response in patients receiving Lu-iPSMA therapeutic doses. Lu-iPSMA was obtained from lyophilized formulations with radiochemical purities >98%. Read More

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November 2018

A Case of Sjögren's Syndrome Mimicking Inflammatory Myopathy.

Cureus 2018 Oct 1;10(10):e3393. Epub 2018 Oct 1.

Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.

Sjögren's syndrome (SS) is a chronic autoimmune disorder, characterized by lymphocytic infiltration of exocrine glands and causing the decreased function of lacrimal and salivary glands. We describe a case of a 34-year-old male who presented with Sjögren's syndrome presenting as myopathy and sensorimotor neuropathy. His creatinine kinase levels were elevated with positive anti-Sjögren's syndrome-related antigen A autoantibodies and anti-Sjögren's syndrome Type B autoantibodies. Read More

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October 2018

Pro-inflammatory Monocyte Phenotype and Cell-Specific Steroid Signaling Alterations in Unmedicated Patients With Major Depressive Disorder.

Front Immunol 2018 23;9:2693. Epub 2018 Nov 23.

Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Several lines of evidence have strongly implicated inflammatory processes in the pathobiology of major depressive disorder (MDD). However, the cellular origin of inflammatory signals and their specificity remain unclear. We examined the phenotype and glucocorticoid signaling in key cell populations of the innate immune system (monocytes) vs. Read More

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November 2018

OSC29: Estimation of Psychological and Oxidative Salivary Stress Markers in Edentulous Patients Wearing Complete Dentures.

J Indian Prosthodont Soc 2018 Oct;18(Suppl 1):S20

SRM Dental College and Hospital, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu- 600089.

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October 2018

Transcriptome-wide responses of adult melon thrips (Thrips palmi) associated with capsicum chlorosis virus infection.

PLoS One 2018 7;13(12):e0208538. Epub 2018 Dec 7.

Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St. Lucia, Queensland, Australia.

Thrips palmi is a widely distributed major agricultural pest in the tropics and subtropics, causing significant losses in cucurbit and solanaceous crops through feeding damage and transmission of tospoviruses. Thrips palmi is a vector of capsicum chlorosis virus (CaCV) in Australia. The present understanding of transmission biology and potential effects of CaCV on T. Read More

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December 2018

Activation of E2F-dependent transcription by the mouse cytomegalovirus M117 protein affects the viral host range.

PLoS Pathog 2018 Dec 10;14(12):e1007481. Epub 2018 Dec 10.

Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.

Cytomegaloviruses (CMVs) have a highly restricted host range as they replicate only in cells of their own or closely related species. To date, the molecular mechanisms underlying the CMV host restriction remain poorly understood. However, it has been shown that mouse cytomegalovirus (MCMV) can be adapted to human cells and that adaptation goes along with adaptive mutations in several viral genes. Read More

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December 2018

Volatilomic insight of head and neck cancer via the effects observed on saliva metabolites.

Sci Rep 2018 Dec 7;8(1):17725. Epub 2018 Dec 7.

Proteomics Lab, National Centre for Cell Science (NCCS), Ganeshkhind, SPPU Campus, Pune, 411007, India.

Head and neck cancer (HNC) is a heterogeneous malignant disease with distinct global distribution. Metabolic adaptations of HNC are significantly gaining clinical interests nowadays. Here, we investigated effects of HNC on differential expression of volatile metabolites in human saliva. Read More

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December 2018

Pleomorphic adenoma of the mandibular salivary gland in a captive African pygmy hedgehog (Atelerix albiventris).

J Vet Med Sci 2018 Dec 7. Epub 2018 Dec 7.

Department of Veterinary Pathology and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University.

A 3.9-year-old female African pygmy hedgehog (Atelerix albiventris) had a firm, tan-colored mass with an uneven surface arising from the mandibular salivary gland. A histopathologic examination revealed that the mass was composed of neoplastic proliferation of epithelial and spindle cells. Read More

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December 2018

Effect of mucoadhesive agent HEC on herbal extracts retention and VSC producing bacteria reduction in an experimental oral biofilm.

J Breath Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Prosthodontics, Tel Aviv University, Goldschleger School of Dental Medicine, Ramat Aviv, Tel Aviv, 69978, ISRAEL.

Mucoadhesive tablets containing herbal formulation have been previously shown to reduce oral malodour. The aim of the present in vitro study was to test the effect of the mucoadhesive agent hydroxyethylcellulose (HEC) added to a liquid phase herbal extract formulation on the mucoadhesive retention of the active ingredients and their effect against malodour production. Experimental oral biofilms were grown on mucin coated glass slides treated with liquid phase solutions of herbal extract with or without HEC as well as saline and 0. Read More

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December 2018
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Establishing Digital Biomarkers for Occupational Health Assessment in Commercial Salmon Fishermen: Protocol for a Mixed-Methods Study.

JMIR Res Protoc 2018 Dec 10;7(12):e10215. Epub 2018 Dec 10.

RTI International, RTP, NC, United States.

Background: Commercial salmon fishing in Alaska is one of the most dangerous occupations in the United States. Between 1992 and 2008, the average annual industry mortality rate was 128 deaths per 100,000 workers, and despite an increase in industry regulations, there has not been a significant decrease in mortality rate since 2000. Unpredictable fishing openings and fierce competition for limited resources result in periods of intense sleep deprivation and physical strain during the short commercial salmon season in Alaska. Read More

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December 2018

Telomere length and salivary cortisol stress reactivity in very preterm infants.

Early Hum Dev 2018 Dec 6;129:1-4. Epub 2018 Dec 6.

0-3 Center for the at-Risk Infant, Scientific Institute IRCCS Eugenio Medea, via Don Luigi Monza 20, 23842 Bosisio Parini, Lecco, Italy.

During the Neonatal Intensive Care Unit (NICU) stay, very preterm (VPT) infants are exposed to life-saving yet pain-inducing skin-breaking procedures (i.e., NICU pain-related stress) which contribute to the programming of hypo-responsive HPA axis development during the first months of life. Read More

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December 2018
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Salivary cortisol levels and biological rhythm in schoolchildren with sleep bruxism.

Sleep Med 2018 Oct 28;54:48-52. Epub 2018 Oct 28.

Department of Health and Behavior, Catholic University of Pelotas, Pelotas, RS, Brazil.

Objective: Salivary cortisol levels and biological rhythms could be hypothesized as part of the multifactorial framework that explains bruxism etiology. The objective of this study was to examine salivary cortisol levels and biological rhythms in schoolchildren with sleep bruxism (SB).

Methods: This is a cross-sectional study with a school-based sample. Read More

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October 2018

Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy.

Sleep Med 2018 Oct 31;54:35-42. Epub 2018 Oct 31.

Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Objective: To assess the diurnal melatonin, cortisol, and activity/rest levels, as well as sleep quality, in patients with and without nonproliferative diabetic retinopathy (DR).

Methods: We included 25 diabetic patients with DR and 29 without DR. A total of 21 healthy subjects constituted the control group. Read More

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October 2018

Child's oxytocin response to mother-child interaction: The contribution of child genetics and maternal behavior.

Psychoneuroendocrinology 2018 Nov 16;102:79-83. Epub 2018 Nov 16.

CIPsi, School of Psychology, University of Minho, Portugal. Electronic address:

The oxytocinergic system is a primary biological system involved in regulating a child's needs for bonding and for protection from threats. It is responsive to social experiences in close relationships, though evidence across studies is not entirely consistent. Guided by previous literature, we investigated individual and environmental factors predicting and presumably affecting children's oxytocin (OT) response during mother-child interaction. Read More

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November 2018

Resting amygdala connectivity and basal sympathetic tone as markers of chronic hypervigilance.

Psychoneuroendocrinology 2018 Nov 26;102:68-78. Epub 2018 Nov 26.

Hunter College, The City University of New York, 695 Park Avenue, New York, NY 10065, USA; The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, USA. Electronic address:

Background: Chronic hypervigilance, a state of sustained alertness and hyperarousal in the absence of threat, has been shown to predict poorer clinical outcomes post-trauma. An exaggerated and persistent amygdala alerting response to affective information has been proposed as a reactivity-based, and thus indirect, marker of hypervigilance. However, because chronic hypervigilance is a persistent rather than reactive state, it should be directly observable under resting-state conditions without the need for exposure to affectively charged stimuli. Read More

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November 2018

Identification of salivary peptidomic biomarkers in chronic kidney disease patients undergoing haemodialysis.

Clin Chim Acta 2018 Dec 7. Epub 2018 Dec 7.

Department of Preventive Dentistry, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, PR China. Electronic address:

Background: Chronic kidney disease (CKD) is a worldwide public health problem. To detect discriminating salivary peptide profiles between CKD patients undergoing haemodialysis (HD) and healthy controls (HCs) and to screen candidate biomarkers for CKD, we preliminarily explored the diagnostic potentiality of saliva.

Methods: Saliva samples from 30 CKD HD patients and 35 HCs were analysed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with weak cation exchange magnetic beads. Read More

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December 2018

Oxidative stress markers in saliva and plasma differ between diet-controlled and insulin-controlled gestational diabetes mellitus.

Diabetes Res Clin Pract 2018 Dec 6. Epub 2018 Dec 6.

Department of Bioanalysis and Drugs Analysis, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, Poland.

Objectives: The aims of the study were as follows: to investigate possible differences between plasma oxidative status (OS) in late-onset GDM and well-characterized healthy pregnant women (oral health, diet); to verify the existence of possible differences between GDMG1 (diet-treated) and GDMG2 (insulin-treated GDM); to determine whether oxidative stress markers could be detected in saliva.

Material And Methods: A total of 89 pregnant women (n=89; 59 with GDM and 30 controls) were evaluated. Malondialdehyde (MDA), total antioxidant capacity (ORAC), inactivation of aldehyde dehydrogenase (I), activity of glutathione peroxidase (GPx) and glutathione transferase (GST)) in plasma and/or saliva were analyzed. Read More

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December 2018

The impact of acute mental stress on brachial artery flow-mediated dilation in women diagnosed with depression.

Int J Psychophysiol 2018 Dec 6. Epub 2018 Dec 6.

School of Kinesiology and Health Studies, 28 Division Street, Queen's University, Kingston K7L 3N6, Ontario, Canada. Electronic address:

Endothelial function, assessed by flow-mediated dilation (FMD), may be transiently attenuated in healthy adults following acute mental stress. However, the impact of acute mental stress on endothelial function in the context of clinical depression is unknown. This study examined the impact of acute mental stress on FMD in women with a diagnosis of a depressive disorder. Read More

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December 2018

Salivary gland tumors in a Brazilian population: A 20-year retrospective and multicentric study of 2292 cases.

J Craniomaxillofac Surg 2018 Sep 26. Epub 2018 Sep 26.

Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte-UFRN, Av. Senador Salgado Filho, 1787-Lagoa Nova, Natal, RN, 59056-000, Brazil. Electronic address:

Purpose: Neoplasms of the salivary glands comprise more than thirty subtypes of lesions with various clinical behaviors. The present study aimed to describe the incidence and main features of salivary gland tumors in Brazil.

Material And Methods: A retrospective descriptive cross-sectional study was performed (1997-2017). Read More

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September 2018

The limited role of elective neck dissection in patients with cN0 salivary gland carcinoma.

J Craniomaxillofac Surg 2018 Nov 22. Epub 2018 Nov 22.

Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address:

Purpose: To evaluate whether elective neck dissection (END) was beneficial for cN0 patients with salivary gland carcinoma.

Materials And Methods: The rates of regional failure-free survival and disease-free survival were calculated using Kaplan-Meier methods and Cox models. The risk factors for occult lymph node metastasis (OLNM) in cN0 patients undergoing END was analyzed using logistic regression. Read More

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November 2018

Variability in nitrate-reducing oral bacteria and nitric oxide metabolites in biological fluids following dietary nitrate administration: An assessment of the critical difference.

Nitric Oxide 2018 Dec 5. Epub 2018 Dec 5.

Institute for Clinical Exercise and Health Science, University of the West of Scotland, Hamilton, UK. Electronic address:

There is conflicting evidence on whether dietary nitrate supplementation can improve exercise performance. This may arise from the complex nature of nitric oxide (NO) metabolism which causes substantial inter-individual variability, within-person biological variation (CV), and analytical imprecision (CV) in experimental endpoints. However, no study has quantified the CV and CV of NO metabolites or the factors that influence their production. Read More

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December 2018

Salivary markers of hepato-metabolic comorbidities in pediatric obesity.

Dig Liver Dis 2018 Nov 17. Epub 2018 Nov 17.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana" Pediatrics Section, University of Salerno, Baronissi, Salerno, Italy; European Laboratory for Food Induced Intestinal Diseases (ELFID), Naples, Italy.

Background: The pediatric obesity epidemic calls for the noninvasive detection of individuals at higher risk of complications.

Aims: To investigate the diagnostic role of combined salivary uric acid (UA), glucose and insulin levels to screen noninvasively for metabolic syndrome (MetS) and nonalcoholic fatty liver disease.

Methods: Medical history, clinical, anthropometric, and laboratory data including serum triglyceride, glucose, insulin, HOMA, HDL-cholesterol, and UA levels of 23 obese children (15 with [St+] and 8 without [St-] ultrasonographic hepatic steatosis) and 18 normal weight controls were considered. Read More

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November 2018

UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line.

Oral Oncol 2018 Dec 18;87:21-28. Epub 2018 Oct 18.

Department of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI, USA; Department of Otolaryngology, University of Michigan School of Medicine, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Objectives: Limited availability of validated human adenoid cystic carcinoma (ACC) cell lines has hindered the mechanistic understanding of the pathobiology of this malignancy and the development of effective therapies. The purpose of this work was to generate and characterize a human ACC cell line.

Material And Methods: Immediately after surgery, a tumor fragment from a minor salivary gland from the tongue of a female Caucasian was minced, dissociated, and a single cell suspension was plated in fibronectin-coated flasks. Read More

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December 2018

Human papillomavirus-related multiphenotypic sinonasal carcinoma: An emerging tumor type with a unique microscopic appearance and a paradoxical clinical behaviour.

Oral Oncol 2018 Dec 16;87:17-20. Epub 2018 Oct 16.

Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA. Electronic address:

Human papillomavirus (HPV) is well established as a causative factor in most squamous cell carcinomas of the oropharynx (OPSCC). Indeed, a growing awareness over the past two decades that HPV-OPSCC is a distinct form of head and neck cancer has had a profound impact on diagnostic and clinical practices. The sinonasal tract is a second anatomic "hot spot" for HPV-related head and neck carcinomas, but certain pathologic features and the clinical behavior of HPV-related carcinomas at this site remain unclear. Read More

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December 2018

Clinical, pathological and treatment factors associated with the survival of patients with primary pulmonary salivary gland-type tumors.

Lung Cancer 2018 Dec 10;126:174-181. Epub 2018 Nov 10.

Department of Medical Oncology, Changzheng Hospital, Naval Medical University, Shanghai, 200072, China. Electronic address:

Introduction: Primary pulmonary salivary gland-type tumors (p-SGTs) are rare, with poorly understood clinicopathological characteristics and survival. There are only few case reports or small case series, and factors associated with survival need to be identified.

Methods: A population cohort study was conducted using data from patients with histologically diagnosed primary p-SGTs in the Surveillance, Epidemiology and End Results (SEER) database between 1988 and 2013. Read More

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December 2018
3.958 Impact Factor

Salivary myoepithelial cells: an addendum.

Ultrastruct Pathol 2018 Dec 10:1-12. Epub 2018 Dec 10.

m Coordinator of the International Head and Neck Scientific Group , Padua , Italy.

Salivary myoepithelial cells bear particular appendages and are involved in processes that have received incomplete attention in previous reviews. Here, cilia on myoepithelial cells are reviewed as regards substructure, occurrence, detection (electron microscopy, double immunofluorescence together with confocal microscopy), and roles (sensory reception, evolutionary homology, paracrine interaction). Attention is drawn to regressive changes affecting those cells (e. Read More

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December 2018

Excision of tumors in the parapharyngeal space using an endoscopically assisted transoral approach: a case series and literature review.

J Int Med Res 2018 Dec 11:300060518816190. Epub 2018 Dec 11.

2 Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Objective: Magnetic resonance imaging (MRI) provides important information regarding tumors in the parapharyngeal space (PPS), revealing their origin, whether they are benign or malignant, and their relationships with surrounding structures.

Methods: Twelve tumors in the PPS were completely excised using an endoscopically assisted transoral approach (EATA). The MRI features were analyzed. Read More

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December 2018