428 results match your criteria Salivary Gland Tumors Major Benign


Polar Vessel: A New Ultrasound Sign for Complementary Diagnosis of Major Salivary Gland Adenoid Cystic Carcinoma.

J Ultrasound Med 2022 Jun 20. Epub 2022 Jun 20.

Department of Ultrasound, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Objectives: To investigate the characteristic ultrasonographic findings of adenoid cystic carcinoma (ACC) in major salivary glands and identify the value of polar vessel in color Doppler flow imaging (CDFI) for the diagnosis of ACC.

Methods: From January 2017 to December 2021, 76 patients with parotid and submandibular gland tumors, including 14 patients with ACC, as confirmed by surgery and histopathology, were enrolled. Their clinicopathologic information and ultrasound (US) features were recorded and analyzed. Read More

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Salivary gland organoid culture maintains distinct glandular properties of murine and human major salivary glands.

Nat Commun 2022 Jun 7;13(1):3291. Epub 2022 Jun 7.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.

Salivary glands that produce and secrete saliva, which is essential for lubrication, digestion, immunity, and oral homeostasis, consist of diverse cells. The long-term maintenance of diverse salivary gland cells in organoids remains problematic. Here, we establish long-term murine and human salivary gland organoid cultures. Read More

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Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study.

Head Neck Pathol 2022 May 27. Epub 2022 May 27.

Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK.

Background: Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only.

Methods: This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. Read More

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Polarized Microscopic Analysis of Picrosirius Red Stained Salivary Gland Pathologies: An Observational Study.

Eur J Dent 2022 May 17. Epub 2022 May 17.

Department of Anatomy, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

Objective:  Salivary gland diseases and their pathologies may affect the glandular structure including collagen, a major stromal component, in response to tissue damage or diseases. This study aimed to examine the changes in collagens in different salivary gland diseases using polarized picrosirius red staining.

Materials And Methods:  The submandibular gland samples diagnosed as sialadenitis, chronic sclerosing sialadenitis, pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma were stained with picrosirius red, Masson's trichrome, and anticollagen I staining. Read More

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Mucoepidermoid carcinoma - A common neoplasm at an unusual site, mimicking a benign cyst on cytology: Diagnostic pitfall!

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S30-S33. Epub 2022 Feb 28.

Department of Pathology, Kasturba Medical College, Manipal, Karnataka, India.

Mucoepidermoid carcinoma (MEC) is known to be a relatively common neoplasm of the major and minor salivary glands that can secondarily involve skin. The clinical manifestations, diagnostic cytology and histopathology of MEC presenting as a clinically benign periauricular cystic nodule have been analyzed. The challenge of accurate diagnosis can be illustrated by the fact that initially, on cytology, this tumor was misdiagnosed as a benign epidermal inclusion cyst due to the presence of mucin-filled cells which were misinterpreted as cyst macrophages. Read More

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February 2022

Oral Squamous Cell Carcinoma and Warthin Tumour Occurring As Synchronous Tumours: A Report of Two Cases.

Cureus 2022 Feb 23;14(2):e22547. Epub 2022 Feb 23.

Oral Cancer Research and Coordinating Centre, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, MYS.

Oral cancer is a common site of cancer worldwide with oral squamous cell carcinoma (OSCC) comprising the major segment. The risk factors include tobacco and alcohol abuse, betel quid, and areca nut consumption. Warthin tumour (WT), also known as papillary cystadenoma lymphomatosum is a benign tumour of the salivary gland. Read More

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February 2022

Clear Cell Neoplasms of Salivary Glands: A Diagnostic Challenge.

Adv Anat Pathol 2022 Jul 7;29(4):217-226. Epub 2022 Mar 7.

International Head and Neck Scientific Group, Padua, Italy.

This review focuses on the heterogenous group of clear cell neoplasms of salivary glands and attempts to identify major differential diagnostic features. Within the head and neck region, clear cells are found most commonly in salivary gland tumors, but may also be seen in tumors of squamous or odontogenic epithelial origin, primary or metastatic carcinomas, benign or malignant melanocytic lesions, or benign or malignant mesenchymal tumors. Clear cells occur fairly commonly among a wide variety of salivary gland neoplasms, but mostly they constitute only a minor component of the tumor cell population. Read More

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F-fluorodeoxyglucose PET/Computed Tomography: Head and Neck Salivary Gland Tumors.

PET Clin 2022 Apr 26;17(2):249-263. Epub 2022 Feb 26.

Department of Radiology, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Salivary gland tumors (SGTs) are a heterogeneous group of neoplasms arising from the 3 pairs of major salivary glands (parotid, submandibular, and sublingual) or numerous minor salivary glands located throughout the oral cavity. This review discusses the role of PET/computed tomography (CT) in evaluation of SGTs, including staging, restaging, prognostication, and response assessment. 18F-fluorodeoxyglucose (FDG) PET/CT is useful for staging and restaging malignant SGTs and offers important prognostic information in these patients. Read More

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Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.

Auris Nasus Larynx 2022 Aug 31;49(4):547-553. Epub 2022 Jan 31.

Department of Otorhinolaryngology, School of Medicine and Surgery, University of Milano- Bicocca, Milan, Italy.

Objectives: To evaluate surgical approaches and outcomes of pleomorphic adenoma of parotid gland in pediatric population.

Methods: A systematic search of PubMed and EMBASE was performed to identify articles reporting surgical treatment of pleomorphic adenoma of the parotid gland in children. A qualitative analysis on results was conducted. Read More

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Results of histopathological revisions of major salivary gland neoplasms in routine clinical practice.

J Clin Pathol 2022 Jan 18. Epub 2022 Jan 18.

Department of Otorhinolaryngology and Head and Neck Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

Aims: Salivary gland neoplasms are rare and are characterised by overlapping histopathological aspects. Therefore, the assessment of the correct histopathological diagnosis can be challenging. This study evaluated the frequency of pathology consultations and revisions for salivary gland neoplasms during routine clinical practice in the Netherlands. Read More

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January 2022

Mélange of Lymphoepithelial Lesions of Salivary Glands from a Tertiary Care Center of North East India: Diagnostic Conundrums.

J Lab Physicians 2021 Dec 12;13(4):338-345. Epub 2021 Jul 12.

Department of Pathology, North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences, Shillong, Meghalaya, India.

Lymphocytic infiltrates of the major salivary glands are involved in a spectrum of diseases that range from reactive to benign and malignant neoplasms. Occasionally, these pathologic entities present difficulties in the clinical and pathological diagnosis. The aim of this study was to highlight the importance of meticulous cytopathological and histopathological examination (HPE) in solving the diagnostic challenges encountered in the analysis of these salivary gland lesions. Read More

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December 2021

A mechanistic basis for the malignant progression of salivary gland tumors.

iScience 2021 Dec 25;24(12):103508. Epub 2021 Nov 25.

Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR 97239, USA.

Salivary gland tumors are diverse neoplasms, likely reflecting differences in the tissue- and cell-of-origin. 80%-90% of tumors arising in the sublingual gland (SLG) are malignant, whereas the other major glands often form benign tumors. Owing to the lack of experimental models to explore the etiology of salivary gland tumors, the cellular and molecular bases of malignancy remain unknown. Read More

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December 2021

Fine-Needle Aspiration Cytology of Salivary Gland Tumors Before the Milan System: Ten Years of Experience at a Tertiary Care Center in Turkey.

Medeni Med J 2021 30;36(3):233-240. Epub 2021 Sep 30.

Haydarpaşa Numune Training and Research Hospital, Department of Otorhinolaryngology and Head and Neck Surgery, İstanbul, Turkey.

Objective: The role of fine-needle aspiration cytology (FNAC) is well established for preoperative evaluation of patients with salivary gland lesions. However, the lack of a uniform system for salivary gland FNAC has limited its effectiveness. In recent years, the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has been in use around the world to report the cytology results. Read More

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September 2021

Mucoepidermoid carcinoma of the anterior lingual salivary gland: A rare case report.

Mol Clin Oncol 2022 Jan 14;16(1). Epub 2021 Nov 14.

Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Ryukyu University, Nishihara, Okinawa 903-0215, Japan.

Mucoepidermoid carcinomas (MECs) are rare head and neck malignant tumours that were originally considered to be benign. It has been estimated that ~20% of MECs in the major salivary glands, such as the parotid gland, and 50% in the several minor salivary glands found in the oral cavity, are malignant. The diagnosis of MECs is mainly based on ancillary and immunohistochemistry testing. Read More

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January 2022

A Tissue Section-Based Near-Infrared Spectroscopical Analysis of Salivary Gland Tumors.

Cancers (Basel) 2021 Oct 26;13(21). Epub 2021 Oct 26.

Department of Diagnostic Sciences, Ghent University Hospital, 9000 Ghent, Belgium.

SGTs vary in histological behavior. Mucins, a major component in salivary glands, consist of a glycosylated and sialylated protein core. Rapid evolutions in glycobiology have demonstrated the important role of glycoproteins in cancer development. Read More

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October 2021

Rare Case Report: Young Male Hard Palate Pleomorphic Adenoma.

Indian J Otolaryngol Head Neck Surg 2021 Dec 27;73(4):510-513. Epub 2020 May 27.

Uday Nursing Home, Jabalpur, India.

Salivary gland tumors are rare and accounting for only 2-3% of tumors occurring in head and neck region. Pleomorphic adenoma is a benign neoplasm which is very commonly encountered in the parotid gland and other major salivary glands. Few times they can also develop in minor salivary glands of the palate. Read More

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December 2021

Extracapsular Dissection for Small Benign Tumors of Parotid Gland: A Case Report on Contemporary Technique.

Cureus 2021 Aug 8;13(8):e17007. Epub 2021 Aug 8.

Department of Oral and Maxillofacial Surgery, St. Joseph Dental College, Eluru, IND.

Salivary gland tumor looms as painless enlarging mass which may embrace in both major or minor glands. Pleomorphic adenoma (PA) accord about 40-70% of all salivary gland tumors, where Warthin tumor, basal cell adenoma (BCA), adenoid cystic carcinoma (ACC), and sebaceous tumors have a strong predilection for major salivary gland. However, polymorphous low-grade adenocarcinoma (PLGA) has a marked predilection for the minor salivary gland. Read More

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A clinical study of submandibular schwannoma.

Oral Surg Oral Med Oral Pathol Oral Radiol 2022 01 16;133(1):e6-e9. Epub 2021 Jul 16.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School & Hwasun Hospital, Hwasun, South Korea.

Objective: Schwannoma is a slowly growing benign neurogenic tumor that develops from the cells of the nerve sheath. The occurrence of schwannoma in the submandibular space is very rare.

Materials And Methods: From January 2010 to March 2021, we reviewed all patients who had been operated on in the otolaryngology department over 11 years and found 61 patients diagnosed with schwannomas at the final biopsy after surgery. Read More

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January 2022

Rare case of giant myoepithelioma in minor salivary glands of palate in a 9-year-old child.

Natl J Maxillofac Surg 2021 May-Aug;12(2):284-288. Epub 2021 Jul 15.

Department of Oral and Maxillofacial Pathology and Oral Microbiology, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India.

Myoepitheliomas (MEs) are extremely rare benign neoplasms composed of ectodermally derived contractile smooth muscle cells (myoepithelial cells). Various tissues such as the salivary glands, breast, larynx, and sweat glands show the presence of these myoepithelial cells. They occur, principally, in the parotid gland and infrequently in minor salivary glands. Read More

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Salivary Duct Carcinoma in the External Auditory Canal Causing Ipsilateral Hearing Loss.

Diagnostics (Basel) 2021 Jul 21;11(8). Epub 2021 Jul 21.

Department of Otolaryngology & Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou 333, Taiwan.

: Salivary duct carcinoma (SDC) is a rare aggressive tumor. Most tumors are not confined to the salivary ducts; rather, they invade the major and minor salivary glands. Only a few case reports on such tumors in other primary sites have appeared. Read More

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Parotid pleomorphic and non-pleomorphic adenomas: a mono-institutional series of 512 patients.

Eur Arch Otorhinolaryngol 2022 May 5;279(5):2543-2551. Epub 2021 Aug 5.

Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili, Brescia, Italy.

Purpose: Pleomorphic adenoma (PA) is the most common benign parotid tumor, with a well-known propensity to recur. Many factors have been advocated as prognostic, but there is no consensus on how they affect local control. We studied how PA recurrence-free survival (RFS) may be affected by the most relevant risk factors in a time-to-event analysis, comparing them with those observed in a population of non-PA (NPA). Read More

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HMGA2-WIF1 Rearrangements Characterize a Distinctive Subset of Salivary Pleomorphic Adenomas With Prominent Trabecular (Canalicular Adenoma-like) Morphology.

Am J Surg Pathol 2022 02;46(2):190-199

Department of Pathology, Charles University, Faculty of Medicine in Plzen.

Most of salivary gland neoplasms (benign and malignant) are characterized by recurrent gene fusions. Pleomorphic adenoma (PA), the most frequent salivary gland tumor, is driven by chromosomal rearrangements involving PLAG1 mapped to 8q12 and HMGA2 mapped to 12q13-15 in most cases. Multiple fusion partners have been identified including CTNNB1, FGFR1, LIFR, CHCHD7 and TCEA for PLAG1 fusions and NFIB, WIF1 and FHIT for HMGA2 fusions. Read More

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February 2022

Epithelial-Myoepithelial Carcinoma of the Submandibular Gland: Case Report.

J Nippon Med Sch 2021 ;88(3):238-241

Department of Otorhinolaryngology, Shanghai Tenth People's Hospital, Tongji University.

Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland tumor that occurs mostly in the parotid gland. We report a case of EMC of the submandibular gland in a young man. The patient was aware of a slow-growing mass in the right submandibular gland for 1 year. Read More

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November 2021

Endoscopic Resection of a Massive Pleomorphic Adenoma of the Nasal Septum.

Ear Nose Throat J 2021 May 31:1455613211020972. Epub 2021 May 31.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.

Pleomorphic adenoma is a benign tumor that commonly arises from the major salivary glands, such as the parotid and submandibular glands. However, they rarely originate from the nasal cavity. Herein, we describe the case of a 49-year-old woman who presented with nasal obstruction. Read More

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Pleomorphic adenoma of hard palate: a case report.

Pan Afr Med J 2021 9;38:146. Epub 2021 Feb 9.

Département d´Odontologie Chirurgicale, Faculté de Médecine Dentaire de Rabat, Université Mohammed V, Rabat, Maroc.

Pleomorphic adenoma is a benign mixed tumor, which is composed of myoepithelial and epithelial cells. A fibrous capsule separates these cells from the surrounding tissues. Pleomorphic adenoma is the most common salivary gland tumour accounting for 40-70% of all major and minor salivary gland tumours. Read More

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A case of a borderline adrenal oncocytoma in a 62-year old female.

Acta Chir Belg 2021 Apr 9:1-4. Epub 2021 Apr 9.

Department of Abdominal Surgery, Centre Hospitalier Bois de l'Abbaye, Seraing, Belgium.

Introduction: Adrenal oncocytomas are a rare pathology and only about 160 cases have been reported in the literature.

Case Description: We describe the case of a 62-year old female with an incidentaloma found in the right adrenal gland on a CT scan. Endocrine testing showed a non-secreting lesion. Read More

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Intraparotid Osteolipoma: Treatment Option and Surgical View.

J Craniofac Surg 2021 Jul-Aug 01;32(5):1894-1897

Maxillofacial Surgery Unit, Policlinico San Marco University Hospital, University of Catania, Catania.

Abstract: Osteolipoma is a benign neoplasm originating from the mesenchymal fat tissue cells and characterized by the presence of bone formation. In the head and neck district osteolipoma has been described as parapharyngeal, nasopharinx, submandibular gland, eyelid, floor of the mouth, and skull base lesion. Only 1 case of osteolipoma was reported as a neoplasm of the parotid region. Read More

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Contribution of small tissue biopsy and flow cytometry to preoperative cytological categorization of salivary gland fine needle aspirates according to the Milan System: Single center experience on 287 cases.

Diagn Cytopathol 2021 Apr 14;49(4):509-517. Epub 2021 Jan 14.

Department of Cytopathology, Faculty of Medicine, Ankara University, Ankara, Turkey.

Background: Milan system for reporting salivary gland cytopathology (MSRSGC) was proposed to provide a standardized reporting system for salivary gland fine needle aspiration biopsies. Modified Menghini type semi-automatic aspiration biopsy needles provide small tissue fragments (STFs), as well as cellular smears, and immunohistochemical and molecular studies can be performed using the STFs.

Aims: We aimed to evaluate the contribution of STFs and ancillary techniques to pre-operative diagnosis of salivary gland lesions. Read More

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Sebaceous Lymphadenoma: Radiology-Pathology Correlation.

Head Neck Pathol 2021 Jun 4;15(2):593-598. Epub 2021 Jan 4.

Departments of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, 30308, USA.

Sebaceous lymphadenoma is a rare salivary gland neoplasm most commonly occurring in the sixth to eighth decades of life. Cross sectional imaging typically demonstrates a multicystic expansile mass, most commonly occurring in the parotid gland, where the radiographic differential diagnosis would include Warthin tumor in this location and age group. Ultimately, the diagnosis is confirmed with the histopathologic findings of tubuloglandular epithelial profiles with sebaceous differentiation and cystic change set within a dense, benign lymphocytic infiltrate. Read More

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Oncocytic mucoepidermoid carcinoma (OMEC) of the parotid gland in a 12-year-old patient: A diagnostic challenge on cytology.

Diagn Cytopathol 2021 Feb 15;49(2):E60-E64. Epub 2020 Aug 15.

Department of Pathology, King George's Medical University, Lucknow, India.

Mucoepidermoid carcinoma is the most common malignant salivary gland neoplasm comprising approximately 10% of all tumours of the major salivary gland. Owing to a plethora of morphological variations, it poses a diagnostic challenge on fine-needle aspiration cytology. Oncocytic variant of mucoepidermoid carcinoma is a rare subtype seen in the age group of 20-80 years. Read More

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February 2021