19,990 results match your criteria Salivary Gland Neoplasms


Sensitivity of Fine-Needle Aspiration and Imaging Modalities in the Diagnosis of Low-Grade Mucoepidermoid Carcinoma of the Parotid Gland.

Ann Otol Rhinol Laryngol 2019 Apr 16:3489419842582. Epub 2019 Apr 16.

1 Department of Otolaryngology-Head and Neck Surgery, BS, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: To determine the diagnostic accuracy of fine-needle aspiration (FNA) and imaging modalities for low-grade mucoepidermoid carcinoma (MEC) of the parotid gland.

Methods: Retrospective chart review of patients diagnosed with low-grade MEC of the parotid gland following surgical excision between January 2010 and June 2018. Imaging from patients with MEC were randomly mixed with imaging from patients with benign pathology and reviewed in a blinded fashion. Read More

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http://dx.doi.org/10.1177/0003489419842582DOI Listing

Myoepithelial Cell Carcinoma of the Oral Tongue: Case Report and Review of the Literature.

Clin Med Insights Oncol 2019 2;13:1179554919838254. Epub 2019 Apr 2.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of New Mexico Hospital, UNM School of Medicine, Albuquerque, NM, USA.

Background: Myoepithelial cell carcinoma is a rare malignant neoplasm of salivary gland origin that typically presents in the parotid gland and minor salivary glands. It has been described previously in head and neck sites such as buccal mucosa, alveolar ridge, and base of tongue.

Methods: A 55-year-old man presented with 30 years of right-sided tongue pain and 10 years of gradually worsening ulceration. Read More

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http://dx.doi.org/10.1177/1179554919838254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448097PMC
April 2019
2 Reads

Metastatic lung cancer associated with Warthin's tumour.

Niger J Clin Pract 2019 Apr;22(4):585-587

Department of Pulmonary Diseases, Health Sciences University Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey.

Warthin's tumors which can easily be subjected to misinterpretation are encountered commonly in clinical practice. Warthin's tumors which generally have the localization of parotid gland cauda and have a slow growing characteristic can rarely be seen aside from parotid gland; such as cervical lymph nodes and minor salivary glands. A 56-year-old patient's case that comprised atypical coexistence of Warthin tumor with PET/CT scan positive cervical lymph nodes during the diagnostic examination carried out for a pulmonary mass lesion is presented. Read More

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http://dx.doi.org/10.4103/njcp.njcp_424_18DOI Listing
April 2019
1 Read

Salivary gland carcinoma in Shanghai (2003-2012): an epidemiological study of incidence, site and pathology.

BMC Cancer 2019 Apr 11;19(1):350. Epub 2019 Apr 11.

Department of Oral & Maxillofacial - Head & Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.

Background: Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor salivary glands with oral cancer instead of with salivary gland carcinoma as a whole, because of the international disease coding. Read More

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http://dx.doi.org/10.1186/s12885-019-5564-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458649PMC
April 2019
1 Read

[Clinical features of mucosa-associated lymphoid tissue lymphoma in head and neck].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):362-366

To summarize the clinical features, diagnosis and treatment of mucosa-associated lymphoid tissue(MALT) lymphoma in head and neck. The clinical data of 22 hospitalizedpatients with MALT lymphoma in head and neck during the recent 18 years were analyzed retrospectively. Among the 22 cases, 13 patients showed salivary gland lesions, 4 showed larynx and trachea lesions,3 showed nasopharynx lesions and 2 showed thyroid gland lesions. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.018DOI Listing
April 2019
7 Reads

Palatal swelling in a young adult.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):27-31

Department of Oral Pathology, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamil Nadu, India.

The presence of numerous minor salivary gland tissues in the posterior part of hard palate increases the possibility of salivary gland neoplasms. Minor salivary gland tumor accounts for about 15% of all the salivary gland neoplasms, of which mucoepidermoid carcinoma (MEC) accounts for about 35.9%. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_192_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421911PMC
February 2019
1 Read

High-Resolution MRI Microscopy Coil Assessment of Parotid Masses.

Ear Nose Throat J 2019 Apr 8:145561319839898. Epub 2019 Apr 8.

1 Department of Radiology, University of Chicago, Pritzker School of Medicine, Chicago, IL, USA.

The goal of this study was to determine whether high-resolution magnetic resonance imaging (MRI) microscopy coil imaging can improve the depiction parotid masses. A total of 14 parotid masses, including 7 salivary neoplasms, 2 abnormal lymph nodes, and 5 benign cystic lesions were imaged with T2-weighted and fat-suppressed postcontrast T1-weighted sequences using a 47-mm diameter microscopy coil in addition to conventional MRI sequences acquired with a conventional head and neck neurovascular coil. Compared to conventional parotid MRI sequences, microscopy coil images provided better definition of the margins of neoplasms, provide more detailed definition of lymph node morphology, and better depict certain cyst contents in the superficial portions of the parotid gland. Read More

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http://dx.doi.org/10.1177/0145561319839898DOI Listing
April 2019
4 Reads

Salivary gland neoplasms in non-human primates: A case series and brief literature review.

J Med Primatol 2019 Apr 2. Epub 2019 Apr 2.

Southwest National Primate Research Center at the Texas Biomedical Research Institute, San Antonio, Texas.

Background: Salivary gland neoplasms are rare in non-human primates.

Methods: Thirty-five years of pathology records were reviewed at the Southwest (SNPRC) and Yerkes (YNPRC) National Primate Research Centers. An in-depth literature search for salivary gland neoplasms in non-human primates was performed. Read More

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http://dx.doi.org/10.1111/jmp.12412DOI Listing
April 2019
2 Reads

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland.

Diagn Cytopathol 2019 Mar 26. Epub 2019 Mar 26.

Department of Pathology & Laboratory Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.

Oncocytic and oncocytoid lesions represent a distinct subset of salivary gland lesions. True oncocytic lesions of the salivary gland are entirely composed of oncocytes. These are characterized by the presence of abundant eosinophilic granules due to the presence of abundant cytoplasmic mitochondria. Read More

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http://dx.doi.org/10.1002/dc.24175DOI Listing

Oncological outcomes of parotid gland malignancies: a retrospective analysis of 74 patients.

J Stomatol Oral Maxillofac Surg 2019 Mar 22. Epub 2019 Mar 22.

Department of Otolaryngology-Head and Neck Surgery, University Hospital of Modena, University of Modena and Reggio Emilia, Modena, Italy.

Introduction: Salivary gland malignancies are rare neoplasms whose management has been evolving over the last two decades. Nevertheless, patient outcomes have not improved accordingly.

Objective: In the present paper, factors and variables that could influence Overall, Disease-Specific and Disease-Free Survival, and Loco-Regional Control were analyzed. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.03.006DOI Listing

The Role of Ancillary Techniques in Salivary Gland Cytopathology Specimens.

Acta Cytol 2019 Mar 25:1-11. Epub 2019 Mar 25.

Department of Pathology, Emory University, Atlanta, Georgia, USA,

Salivary gland tumor aspiration cytology is a useful preoperative test to guide the most appropriate clinical and surgical management for these patients. Although salivary gland cytology is often useful to distinguish between non-neoplastic lesions, benign neoplasms and malignant neoplasms, there remain many challenges in this area. Specifically, these tumors are uncommon and may have considerable morphologic overlap, especially in the setting of a malignant tumor. Read More

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https://www.karger.com/Article/FullText/497109
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http://dx.doi.org/10.1159/000497109DOI Listing
March 2019
10 Reads

Is HIF1-a deregulated in malignant salivary neoplasms?

Gene 2019 Mar 19;701:41-45. Epub 2019 Mar 19.

Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil; Dilson Godinho Hospital, Montes Claros, Minas Gerais, Brazil. Electronic address:

Background: There is significant controversy in the literature regarding the relationship between hypoxia and salivary gland neoplasms (SGNs).

Objective: The current study aims to investigate levels of hypoxia markers in both benign and malignant salivary neoplasms.

Patients And Methods: The current study sample is comprised of a total of 62 samples. Read More

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http://dx.doi.org/10.1016/j.gene.2019.03.017DOI Listing

Assessment of salivary endothelin-1 in patients with leukoplakia, submucous fibrosis, oral cancer and healthy individuals - a comparative study.

J Stomatol Oral Maxillofac Surg 2019 Mar 9. Epub 2019 Mar 9.

Faculty of Dental Sciences, Ramaiah University of Applied Sciences, India.

Background: Oral cancer is one of the highly prevalent cancers worldwide being. According to data of GLOBOCAN 2018, the estimated incidence, mortality and 5-year survival rates due to lip, oral cavity and salivary gland cancer in world is (2.0%), (0. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.02.024DOI Listing
March 2019
2 Reads

Differential Expression of PLAG1 in Apocrine and Eccrine Cutaneous Mixed Tumors: Evidence for Distinct Molecular Pathogenesis.

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Cutaneous mixed tumors, also known as chondroid syringomas, are benign adnexal neoplasms that share histomorphologic features with pleomorphic adenomas of the salivary gland. Recent work suggests that the similarity between these 2 tumor types extends to the molecular level because both harbor identical chromosomal rearrangements involving the PLAG1 gene. The resulting nuclear PLAG1 overexpression can be detected by immunohistochemistry and has become a useful diagnostic adjunct for both tumor types. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001393DOI Listing
February 2019
7 Reads

Role of Antioxidants in Minor Salivary Glands Cancer in the Elderly.

J Craniofac Surg 2019 Feb 5. Epub 2019 Feb 5.

Department of Biomorphology.

Background: Minor salivary gland tumors (MSGTs) are infrequent, representing 10% to 15% of all salivary neoplasms. Despite this low frequency, a significant increase in the incidence of these tumors has been reported in the lasts 30 years. While tumors of the salivary glands can appear at any age, different authors consider the peak of incidence to be associated with old age (60+). Read More

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http://dx.doi.org/10.1097/SCS.0000000000005172DOI Listing
February 2019
3 Reads

Primary salivary gland-type tumors of the lung: A systematic review and pooled analysis.

Lung India 2019 Mar-Apr;36(2):118-122

Department of Cancer Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Introduction: Primary salivary gland-type tumors of the lung (PSGTTL) are rare intrathoracic malignant neoplasms. Their description in literature is largely limited to a few case series and case reports. A systematic review and pooled analysis of the previously reported cases of PSGTTL is presented here. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_284_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410586PMC
March 2019
2 Reads

Lymph node ratio predictive of recurrence, distant metastasis, and survival in submandibular gland carcinoma patients.

J Cancer Res Clin Oncol 2019 Apr 26;145(4):1055-1062. Epub 2019 Feb 26.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Purpose: Submandibular gland (SMG) carcinoma has an unfavorable clinical course and a low survival rate. Specific tumor and nodal findings might help predict posttreatment recurrence and survival in SMG carcinoma patients. This study evaluated factors predictive of posttreatment recurrence and survival in SMG carcinoma patients. Read More

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http://dx.doi.org/10.1007/s00432-019-02876-5DOI Listing

Immunohistochemistry Using a Pan-TRK Antibody Distinguishes Secretory Carcinoma of Salivary Gland from Acinic Cell Carcinoma.

Histopathology 2019 Feb 23. Epub 2019 Feb 23.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Aims: Secretory carcinoma (previously known as mammary analog secretory carcinoma) is characterized by ETV6 rearrangements, most often ETV6-NTRK3 fusion. Given its histologic overlap with other salivary gland tumors, secretory carcinoma can be difficult to diagnose without genetic confirmation. A recently developed pan-TRK antibody shows promise for identifying tumors with NTRK fusions. Read More

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http://dx.doi.org/10.1111/his.13845DOI Listing
February 2019
1 Read

Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.

Am J Surg Pathol 2019 May;43(5):601-609

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Myoepithelial carcinoma (MECA) is an underrecognized challenging entity with a broad morphologic spectrum. Misinterpreting MECA is not uncommon as distinguishing it from its mimics, especially cellular myoepithelial-rich pleomorphic adenoma (PA), can be difficult. We described 21 histologically challenging cases of MECAs (16 MECA ex-PA and 5 MECA de novo). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001218DOI Listing
May 2019
1 Read

Clinicopathological and immunohistochemical analysis of spindle cell squamous cell carcinoma of the tongue: a rare case.

Einstein (Sao Paulo) 2019 Feb 18;17(1):eRC4610. Epub 2019 Feb 18.

Universidade Estadual da Paraíba, Campina Grande, PB, Brazil.

Spindle cell squamous cell carcinoma of the tongue is a rare variant of squamous cell carcinoma. This paper reports the case of a spindle cell squamous cell carcinoma of the tongue, in a 64-year-old male patient, and presents a review of the etiopathogenesis, clinicopathological and immunohistochemical features and treatment of the malignancy. The patient presented for evaluation of a painful swelling on his tongue. Read More

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http://dx.doi.org/10.31744/einstein_journal/2019RC4610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377040PMC
February 2019

Necrotizing sialometaplasia can hide the presence of salivary gland tumors: A case series.

Oral Dis 2019 May 5;25(4):1084-1090. Epub 2019 Mar 5.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Objective: Necrotizing sialometaplasia (NS) is an uncommon benign process which affects minor and, more rarely, major salivary glands. While self-limiting, the condition might be clinically and histologically mistaken for malignancy. Furthermore, NS may accompany neoplasms. Read More

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http://doi.wiley.com/10.1111/odi.13066
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http://dx.doi.org/10.1111/odi.13066DOI Listing
May 2019
17 Reads

Adjuvant androgen deprivation therapy for poor-risk, androgen receptor-positive salivary duct carcinoma.

Eur J Cancer 2019 Mar 13;110:62-70. Epub 2019 Feb 13.

Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, the Netherlands. Electronic address:

Aim: Salivary duct carcinoma (SDC), an aggressive subtype of salivary gland cancer, is androgen receptor (AR)-positive in 67-96% of cases. In patients with locally recurrent and metastatic (R/M) AR-positive SDC, androgen deprivation therapy (ADT) has an overall response rate of 18-64.7%. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.035DOI Listing
March 2019
1 Read

Two case reports of synchronous unilateral pleomorphic adenoma and cystadenolymphoma of the parotid gland with literature review.

J Ultrason 2018 ;18(75):369-373

Department of Otorhinolaryngology, Head and Neck Surgery , Klinikum Augsburg, Augsburg , Germany.

Synchronous unilateral tumors in the parotid glands account for less than 5-10% of all salivary gland neoplasms. Mostly these are cystadenolymphomas, but tumors of different histological types can be found as well. In these cases it is often pleomorphic adenoma in combination with cystadenolymphoma. Read More

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http://dx.doi.org/10.15557/JoU.2018.0055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444322PMC
January 2018
1 Read

Alpha-L-fucosidase-1 is a diagnostic marker that distinguishes mucoepidermoid carcinoma from squamous cell carcinoma.

Pathol Int 2019 Feb 6;69(2):76-85. Epub 2019 Feb 6.

Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.

Alpha-L-fucose is a component of glycans on the cell surface. Alpha-L-fucose is correlated with tumorigenesis and malignancy, and alpha-L-fucosidase-1 (FUCA1), the enzyme that removes terminal α-L-fucose residues from glycoproteins, is downregulated in some high malignancy cancers. The expression profile of FUCA1 in head and neck tumors remains unknown, and we analyzed the expression profiles of FUCA1 and an upstream molecule p53 in mucoepidermoid carcinoma (MEC) and oral squamous cell carcinoma (OSCC). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pin.12764
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http://dx.doi.org/10.1111/pin.12764DOI Listing
February 2019
3 Reads

[Epithelial tumors of salivary glands. Review of 286 pathology reports].

Rev Med Chil 2018 Dec;146(10):1159-1166

Departamento de Anatomía Patológica, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Epithelial tumors of the salivary glands, including benign tumors and aggressive malignancies with different prognoses, are uncommon.

Aim: To describe the frequency and distribution of salivary gland tumors according to age, gender and anatomical location.

Material And Methods: Review of pathological reports of salivary gland tumors of a Pathology laboratory at a clinical hospital from 2006 to 2016. Read More

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http://dx.doi.org/10.4067/S0034-98872018001001159DOI Listing
December 2018
3 Reads

Induction of squamous cell carcinoma after MAP3K8 overexpression in murine salivry gland epithelial cells.

Head Neck 2019 Apr 5;41(4):924-929. Epub 2019 Feb 5.

Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Salivary gland neoplasms are relatively rare and comprise only 1%-4% of all human neoplasms. Salivary gland neoplasms also show an extremely wide range of morphological diversity. Currently, the genetic alterations and corresponding molecular mechanisms underlying salivary gland neoplasms development remain largely unknown. Read More

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http://dx.doi.org/10.1002/hed.25411DOI Listing
April 2019
2 Reads

Uptake of F-Fluorodeoxyglucose in Major Salivary Gland Cancer Predicts Survival Adjusting for Pathological Stage.

Anticancer Res 2019 Feb;39(2):1043-1049

Department of Head and Neck Surgery, Aichi Cancer Center, Nagoya, Japan.

Aim: To investigate whether F-fluorodeoxyglucose uptake is associated with overall survival in patients with major salivary gland cancer using univariate and multivariate analyses after adjusting for pathological stage (eighth edition of the International Union Against Cancer).

Patients And Methods: A total of 32 patients with major salivary gland cancer treated with curative surgery were enrolled. Parameters for F-fluorodeoxyglucose uptake were assessed by positron-emission tomography combined with computed tomography. Read More

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http://dx.doi.org/10.21873/anticanres.13211DOI Listing
February 2019
1 Read

Survival Probabilities Related to Histology, Grade and Stage in Patients With Salivary Gland Tumors.

Anticancer Res 2019 Feb;39(2):641-647

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion - Israel Institute of Technology, Haifa, Israel

Background: The diversity of malignant salivary gland tumors challenges the study of survival rates. The current study evaluated patient survival rates using Kaplan-Meier analysis and examined the relative effects of histology, grade and stage on survival.

Materials And Methods: Using the Kaplan-Meier model, cancer-specific (CSS) and disease-free (DFS) survival probabilities were calculated as a function of time. Read More

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http://dx.doi.org/10.21873/anticanres.13158DOI Listing
February 2019

IgG4-related disease: what a hematologist needs to know.

Haematologica 2019 Mar 31;104(3):444-455. Epub 2019 Jan 31.

Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

IgG4-related disease is a fibro-inflammatory condition that can affect nearly any organ system. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal fibrosis and tubulointerstitial nephritis. This review focuses on the hematologic manifestations of IgG4-related disease, including lymphadenopathy, eosinophilia, and polyclonal hypergammaglobulinemia. Read More

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http://dx.doi.org/10.3324/haematol.2018.205526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395313PMC
March 2019
7 Reads

Computed tomographic features of adenoid cystic carcinoma in the palate.

Cancer Imaging 2019 Jan 31;19(1). Epub 2019 Jan 31.

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth Peoples Hospital, College of Stomatology Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.

Background: To evaluate the computed tomographic features and create a prediction model for clinical diagnosis of adenoid cystic carcinoma (ACC) in the palate with intact mucosa.

Methods: From March 2016 to May 2018, 102 patients with palatal tumors and intact mucosa, including 28 patients with a pathological diagnosis of ACC after surgery, were enrolled in this study. The patients' clinical symptoms, computed tomographic features and pathological diagnoses were recorded and analyzed. Read More

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https://cancerimagingjournal.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s40644-019-0190-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357373PMC
January 2019
13 Reads

Ectopic pleomorphic adenoma on subcutaneous plane of the cheek.

Arch Craniofac Surg 2019 Feb 1;20(1):55-57. Epub 2019 Feb 1.

Department of Plastic and Reconstructive Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.

Pleomorphic adenoma is the most common benign tumor of the salivary gland. Pleomorphic adenoma occurs most commonly in the parotid gland but it may involve other salivary gland such as submandible or lingual. We report an ectopic pleomorphic adenoma in the subcutaneous layer of the face. Read More

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http://e-acfs.org/journal/view.php?doi=10.7181/acfs.2018.019
Publisher Site
http://dx.doi.org/10.7181/acfs.2018.01949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411524PMC
February 2019
13 Reads

18F-FDG PET/CT for staging and response assessment of primary parotid MALT lymphoma with multiple sites involvement: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14270

Department of Nuclear Medicine, Lanzhou University Second Hospital, Lanzhou University.

Rationale: Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade B cell lymphoma that generally exhibits an indolent clinical course. Currently, the application of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in MALT lymphoma is still controversial. Herein, we reported a case of using F-FDG PET/CT for staging and response assessment of primary parotid MALT lymphoma with multiple sites involvement. Read More

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http://dx.doi.org/10.1097/MD.0000000000014270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380729PMC
February 2019
12 Reads

Prevalence of Fatigue in Head and Neck Cancer Survivors.

Ann Otol Rhinol Laryngol 2019 May 30;128(5):413-419. Epub 2019 Jan 30.

2 Supportive Care Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Introduction: In head and neck cancer (HNC) patients, fatigue is present throughout the course of treatment and during follow-up. There are limited data about the prevalence and factors associated with fatigue in HNC survivors. The objectives of this study were to assess the prevalence of fatigue and its interference with daily life activities and examine the association between fatigue and gender, age, primary tumour site, Human Papillomavirus (HPV) status, previous oncologic therapy, and time since end of treatment. Read More

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http://dx.doi.org/10.1177/0003489419826138DOI Listing
May 2019
21 Reads
1.054 Impact Factor

Risk-based Stratification of Salivary Gland Lesions on Cytology: An Institutional Experience.

Iran J Pathol 2018 17;13(2):220-228. Epub 2018 Jul 17.

Dept. of Pathology, Integral Institute of Medical Sciences and Research, Lucknow, India.

Background & Objective: Fine needle aspiration cytology (FNAC) of salivary gland lesions is an accepted and useful diagnostic tool to differentiate between benign and malignant lesions. Majority of the neoplasms are benign, and specific diagnosis on cytology can be made in most of the cases. However, the utility is limited by the overlapping and heterogeneous morphological features of benign and malignant neoplasms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339488PMC

Assessment of and rearrangements in breast adenomyoepitheliomas.

NPJ Breast Cancer 2019 18;5. Epub 2019 Jan 18.

1Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.

Breast adenomyoepitheliomas (AMEs) are rare epithelial-myoepithelial neoplasms that may occasionally produce myxochondroid matrix, akin to pleomorphic adenomas (PAs). Regardless of their anatomic location, PAs often harbor rearrangements involving or . We have recently shown that the repertoire of somatic genetic alterations of AMEs varies according to their estrogen receptor (ER) status; whilst the majority of ER-positive AMEs display mutually exclusive or hotspot mutations, up to 60% of ER-negative AMEs harbor concurrent Q61 hotspot mutations and mutations affecting either or . Read More

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http://dx.doi.org/10.1038/s41523-018-0101-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338730PMC
January 2019
14 Reads

Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.

Nat Commun 2019 01 21;10(1):368. Epub 2019 Jan 21.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Krankenhausstr. 8-10, 91054, Erlangen, Germany.

The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins of which some are specifically expressed at high levels in the salivary glands and constitute major components of saliva. Here we report on recurrent rearrangements [t(4;9)(q13;q31)] in AciCC that translocate active enhancer regions from the SCPP gene cluster to the region upstream of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) at 9q31. Read More

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http://dx.doi.org/10.1038/s41467-018-08069-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341107PMC
January 2019
5 Reads

Results of cystadenolymphoma treatment of superficial parotid gland.

Otolaryngol Pol 2018 Sep;72(6):23-30

Collegium Medicum Uniwersytetu Mikołaja Kopernika w Toruniu Klinika Otolaryngologii i Laryngologii Onkologicznej z Pododdziałem Audiologii i Foniatrii.

Introduction Warthin's tumor is a non-malignant tumor that occurs in major salivary glands. Diagnostics include an interview and physical examination as well as additional tests - ultrasonography, magnetic resonance tomography, fine-needle aspiration biopsy. Surgical tumor resection remains the method of treatment, the scope of which includes techniques from extracapsular tumor resection to a full range of parotidectomy. Read More

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http://dx.doi.org/10.5604/01.3001.0012.4667DOI Listing
September 2018
3 Reads

[Terebrant basal cell carcinoma].

Pan Afr Med J 2018 30;30:300. Epub 2018 Aug 30.

Service de Dermatologie-Vénérologie, Hôpital d'Instruction Mohammed V, Rabat, Maroc.

Basal cell carcinoma (BCC) is the most frequent skin cancer. It never affects the mucosa. It is characterized by a local malignancy with an extremely rare risk of developing distant metastasis and the lowest mortality. Read More

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http://www.panafrican-med-journal.com/content/article/30/300
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http://dx.doi.org/10.11604/pamj.2018.30.300.16224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320449PMC
January 2019
4 Reads

The diagnostic performance of ultrasonography and computerized tomography in differentiating superficial from deep lobe parotid tumours.

Clin Otolaryngol 2019 Jan 12. Epub 2019 Jan 12.

Department of Otolaryngology Head and Neck Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan (R.O.C.).

Objectives: To validate and compare ultrasound (US) versus computerized tomography (CT) criteria in the localisation of superficial/deep lobe tumours of the parotid gland.

Design And Setting: This was a retrospective study of diagnostic tests performed from January 2008 to June 2017.

Participants: We included adult patients who were referred for a neck ultrasonography examination due to parotid tumours, and who subsequently underwent parotid surgery. Read More

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http://dx.doi.org/10.1111/coa.13289DOI Listing
January 2019
2 Reads

Postoperative radiotherapy for mucoepidermoid carcinoma of the major salivary glands: long-term results of a single-institution experience.

Radiat Oncol J 2018 Dec 31;36(4):317-324. Epub 2018 Dec 31.

Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: This study aimed to evaluate the long-term survival outcomes and prognostic factors that affect the clinical outcomes of patients who underwent surgery and postoperative radiotherapy for major salivary gland mucoepidermoid carcinoma (MEC).

Materials And Methods: We retrospectively reviewed the clinical data of 44 patients who underwent surgery followed by radiotherapy for primary MEC of the major salivary glands between 1991 and 2014. The median follow-up period was 9. Read More

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http://dx.doi.org/10.3857/roj.2018.00409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361245PMC
December 2018
1 Read

[Clinical pathologic analysis on 3 724 cases of salivary gland tumors].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Jan;54(1):10-16

Department of Pathology, Hospital of Stomatology, Jilin University, Changchun 130021, China.

To investigate the incidence and proportion of salivary gland tumors in order to provide new thinking for clinical diagnosis and treatment. Collected 3 724 cases salivary gland tumors diagnosed by Pathology Department of Hospital of Stomatology, Jilin University from January 1961 to December 2016. The pathological diagnosis referred to the fourth edition of head and neck-salivary gland tumor histopathological classification standard of WHO. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.01.003DOI Listing
January 2019
3 Reads

Radiotherapy for parapharyngeal space tumors.

Am J Otolaryngol 2019 Mar - Apr;40(2):289-291. Epub 2018 Dec 21.

Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

A wide variety of tumors, both benign and malignant, occur in the parapharyngeal space. Depending on histology and extent, treatment may include surgery and/or radiotherapy (RT). Herein we discuss the role of RT in the management of some of the more commonly encountered neoplasms, including salivary gland tumors, paragangliomas, schwannomas, and soft-tissue sarcomas. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.12.010DOI Listing
December 2018
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Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors.

Authors:
E V Kochurova

Bull Exp Biol Med 2019 Jan 8;166(3):383-385. Epub 2019 Jan 8.

I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia.

The benign and malignant neoplasms in parotid gland have similar clinical presentations despite different tumor growth rates. The study compared the clinical and morphological data as well as the results of ELISA for MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 in salivary fluid yielded during primary examination of the patients with pleomorphic adenoma and adenocarcinoma of parotid gland. The examined biomarkers detected in salivary fluid in patients with various cancer types differed significantly (p≤0. Read More

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http://dx.doi.org/10.1007/s10517-019-04355-wDOI Listing
January 2019
2 Reads

Parotid incidentalomas on positron emission tomography: what is their clinical significance?

Nucl Med Commun 2019 Mar;40(3):264-269

Norwich Radiology Academy, The Cotman Centre, Norwich.

Objective And Aim: The increased use of PET/CT in cancer staging has resulted in more incidental findings in unexpected locations, making this a challenge for the radiologist interpreting the study. Our aim was to determine the frequency of parotid incidentalomas and to assess the ability of PET/CT to characterize them.

Patients And Methods: At the Norfolk and Norwich University Trust, in between October 2010 to October 2015, 4044 patients had a PET/CT examination. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000961DOI Listing
March 2019
2 Reads

Pediatric follicular lymphoma of the parotid gland.

Arch Craniofac Surg 2018 Dec 27;19(4):279-282. Epub 2018 Dec 27.

Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.

Primary malignant lymphoma rarely presents as a mass in the salivary gland. It accounts for about 1% of salivary gland tumors. The lymphomas of the parotid gland are mainly non-Hodgkin's lymphoma of B-cell follicular type. Read More

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http://dx.doi.org/10.7181/acfs.2018.02075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325339PMC
December 2018
2 Reads

Intraductal Carcinoma of Salivary Glands Harboring TRIM27-RET Fusion with Mixed Low Grade and Apocrine Types.

Head Neck Pathol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pathology and Laboratory Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, L25, Cleveland, OH, 44195, USA.

Intraductal carcinomas (IDCs) of salivary gland are rare neoplasms. Here, we report a case of IDCs harboring TRIM27-RET fusion with mixed low grade and apocrine types. A 79-year-old male presented with slowly-growing left parotid mass for 2. Read More

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http://link.springer.com/10.1007/s12105-018-0996-1
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http://dx.doi.org/10.1007/s12105-018-0996-1DOI Listing
January 2019
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Facial Paralysis Following Core Needle Biopsy of a Deep Lobe Parotid Tumor: A Case Report.

Ann Otol Rhinol Laryngol 2019 Apr 2;128(4):357-359. Epub 2019 Jan 2.

1 Department of Surgery, Division of Otolaryngology-Head & Neck Surgery, University of California, San Diego, CA, USA.

Objectives:: To report a case of total facial paralysis as the result of a core needle biopsy.

Methods:: Case report and literature review.

Results:: A 70-year-old man was diagnosed with a deep lobe parotid tumor on computed tomography. Read More

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http://dx.doi.org/10.1177/0003489418820886DOI Listing
April 2019
1 Read