Search Our Scientific Publications & Authors

Head Neck Pathol 2020 Jun 26. Epub 2020 Jun 26.

Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

Polymorphous adenocarcinoma (PAC) is the second most common malignant salivary gland tumour of minor salivary glands. Human tissue kallikreins (KLKs) are a family of highly conserved serine proteases expressed by various tissues and organs. The literature demonstrates a link between KLKs and salivary gland neoplasms. Read More

Front Oncol 2020 3;10:881. Epub 2020 Jun 3.

Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Salivary gland cancer (SGC) in the oral cavity is not common and has been less studied in comparison with oral squamous cell carcinoma (SCC). This study aimed to identify the clinical characteristics and outcomes of SGC in the oral cavity compared with oral SCC. The medical charts of the patients with SGC ( = 68) arising from minor salivary glands and SCC ( = 750) in the oral cavity between 1995 and 2017 were reviewed retrospectively. Read More

Acta Reumatol Port 2020 Jan-Mar;45(1):69-70

Unidade Local de Saúde do Alto Minho.

Ultrasound-guided core biopsy is a minimally invasive technique able to identify lymphoma accompanying Sjögren syndrome, neoplasms or infiltrative diseases, with less complications compared to open biopsy. With these images, we aim to describe the ultrasound-guided core biopsy procedure, in a female patient with rheumatoid arthritis who presented evident inhomogeneity of the parotid gland. The procedure was performed by rheumatologists, trained in ultrasonography of the salivary glands, demonstrating that ultrasound-guided core biopsy is an easy and safe method to obtain salivary gland tissue. Read More

J Stomatol Oral Maxillofac Surg 2020 Jun 18. Epub 2020 Jun 18.

Department of Oral and Maxillofacial Surgery, University of Texas Health San Antonio, San Antonio, Texas, USA. Electronic address:

Objective: Mucoepidermoid Carcinoma (MEC) is the most common malignant salivary gland neoplasm, representing 10 to 15% of all salivary neoplasms. A review of the literature was conducted in order to determine trends in presentation, diagnostic features, treatment, and outcomes.

Methods: A PubMed, Embase, and Scopus search was carried out. Read More

Diagn Cytopathol 2020 Jun 20. Epub 2020 Jun 20.

Department of Pathology, University of Health Sciences, Elazig Health Practices And Research Center, Elazig, Turkey.

Background: Salivary gland masses constitute a broad spectrum of lesions ranging from non-neoplastic to benign and malignant lesions. Parotid is the largest salivary gland and constitutes 75% to 80% of all salivary gland areas. 80% of parotid lesions are benign and 20% are malignant. Read More

Head Neck Pathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pathology, Dartmouth-Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH, 03756, USA.

Thyroid carcinomas represent 3.2% of all new cases of cancer in the United States. Whereas most thyroid tumors arise from follicular cells or, less commonly, parafollicular cells, the derivation of some rare primary thyroid carcinoma subtypes is less clear and represents an area of evolving knowledge. Read More

Semin Diagn Pathol 2020 May 5. Epub 2020 May 5.

University of Florida College of Medicine Department of Pathology, Immunology and Laboratory Medicine P.O. Box 100275 1600 SW Archer Road Gainesville, FL 32610-0275.

This review focuses on the diagnosis of select benign processes, ranging from reactive entities to heterotopic tissues to neoplasms, which may occur in the mediastinum. Currently, the mediastinum can be evaluated and biopsied with endoscopic procedures. Therefore, cytopathology specimens, fine needle aspirations, and small biopsies play an important role in the diagnosis of these lesions. Read More

J Oral Pathol Med 2020 Jun 12. Epub 2020 Jun 12.

Department of Pathology, Federal University of Santa Catarina, Florianópolis, Brazil.

This study aimed to synthetize and critically appraise available evidence regarding mucoepidermoid carcinoma (MEC) prevalence among intraoral minor salivary gland tumors (MiSGT). Five main electronic databases and three grey literature databases were searched. The risk of bias (RoB) was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data. Read More

Acta Cytol 2020 Jun 11:1-12. Epub 2020 Jun 11.

Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Background: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour in paediatric population, accounting for 16% of all cases. Patients affected by a previous solid or leukaemic neoplasm during their childhood may develop a second different tumour during the follow-up. In this setting, salivary gland MEC is relatively frequent, accounting for 6% of the second neoplasms in paediatric patients. Read More

Diagn Cytopathol 2020 Jun 7. Epub 2020 Jun 7.

Department of Imaging and Pathology, University Hospitals Leuven-KU Leuven, Leuven, Belgium.

Background: Salivary gland fine needle aspiration (FNA) has a well-established role in the evaluation of salivary gland lesions. The Milan system for reporting salivary gland cytopathology (MSRSGC) was developed in 2018 to accomplish a standardized reporting across institutions. This classification is predominantly based on the use of direct smears. Read More

Head Neck Pathol 2020 Jun 6. Epub 2020 Jun 6.

Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.

Salivary gland neoplasms of the buccal mucosa are relatively rare and often present with an unusual histopathologic profile when compared with other intraoral locations. We present a series of minor salivary gland neoplasms of the buccal mucosa and discuss demographics, clinical presentation, and histologic findings. An IRB approved retrospective search of University of Florida Oral Pathology Biopsy Service archive from 1994 to 2018 for all salivary gland neoplasms of the buccal mucosa was undertaken. Read More

BMC Cancer 2020 Jun 5;20(1):519. Epub 2020 Jun 5.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: Treatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a transmembrane protein that is known for its use in diagnostics and targeted therapy in prostate cancer, is also expressed by AdCC. This study aimed to analyse PSMA expression in a large cohort of primary, recurrent and metastasized AdCC of the head and neck. Read More

Head Neck Pathol 2020 May 27. Epub 2020 May 27.

Southern California Permanente Medical Group, Department of Pathology, 5601 De Soto Avenue, Woodland Hills, CA, 91365, USA.

Lymphoepithelial carcinoma of salivary glands (LECSG) are rare neoplasms, reported in endemic populations (southeastern Chinese) with a strong Epstein-Barr virus (EBV) association. A retrospective series comparing EBV status within an ethnically diverse population (endemic vs. non-endemic patients) has not been reported. Read More

Cancer Treat Res Commun 2020 May 12;24:100178. Epub 2020 May 12.

Sunnybrook Odette Cancer Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada. Electronic address:

Introduction: Microglandular adenosis (MGA) is a rare benign proliferative lesion lacking a myoepithelial cell layer; 27% of all reported cases have progressed to invasive carcinoma. Salivary gland-type carcinomas of the breast are also uncommon, representing 2% of all breast cancers. This wide spectrum of neoplasms tends to be triple negative and generally has an excellent prognosis. Read More

J Oral Pathol Med 2020 May 26. Epub 2020 May 26.

Cell Biology and Oral Pathology Division, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.

Background: There has been great interest recently in the mechanisms of cell-to-cell communication through microvesicles (MV). These structures are produced by many different cell types and can modulate cellular activity by induction of epigenetic alterations. These vesicles may promote tumor mass increase either by stimulating cell proliferation via growth factors or by inhibiting apoptosis, which reinforces the role of such vesicles as important modulators of tumor progression. Read More

Diagn Cytopathol 2020 May 26. Epub 2020 May 26.

Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.

Background: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is based on risk stratification. We presented our experience with fine-needle aspiration cytology (FNAC) for the diagnosis of salivary glands lesions by applying the MSRSGC categorization to the cytological diagnoses, and determined risk of malignancy (ROM) for each category.

Methods: Fine-needle aspiration cytology of salivary gland lesions performed over a 6-year period was retrieved. Read More

Eur J Surg Oncol 2020 May 5. Epub 2020 May 5.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:

Objective: Tracheobronchial mucoepidermoid carcinoma (TMEC) is an extremely rare salivary gland-type neoplasm. We aimed to explore the clinical characteristics and prognosis of TMEC and to compare them with those of another rare salivary gland-type neoplasm, tracheobronchial adenoid cystic carcinoma (TACC).

Method: We performed a retrospective review of all patients pathologically diagnosed with TMEC between 1965 and 2017 at our institution. Read More

Otolaryngol Pol 2020 Feb;74(3):17-22

Klinika Otolaryngologii, Onkologii Laryngologicznej, Audiologii i Foniatrii, II Katedra Otolaryngologii, Uniwersytet Medyczny w Łodzi.

Introduction: The paper aims to demonstrate the Clinic's and own research in the treatment of major salivary gland tumors.

Material And Method: In the years 2013-2019, there were 95 salivary gland surgeries, including 45 performed in women (47.36%) aged between 24 and 82 and in 50 men (52. Read More

Med Oral Patol Oral Cir Bucal 2020 May 10. Epub 2020 May 10.

Laboratory of Morphology and Experimental Pathology Institute of Technology and Research, Tiradentes University Av. Murilo Dantas, 300, Farolândia, Aracaju, SE 49032-490, Brazil

Background: Salivary gland tumors (SGT) correspond to a heterogeneous group of lesions with variable biological behavior. The present study aimed to determine the distribution and demographic findings of salivary gland neoplasms in a northeast Brazilian population.

Material And Methods: A retrospective descriptive cross-sectional study was performed. Read More

Sisli Etfal Hastan Tip Bul 2020 24;54(1):88-93. Epub 2020 Mar 24.

Department of Pathology, University of Health Sciences Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: Salivary gland neoplasms are less than 5% of all head and neck neoplasms (1). Although there are morphological similarities between different neoplasms, there may be catchy morphological differences in a single tumour. According to the World Health Organization (WHO), 4 Head and Neck Tumours Classification oncocytic salivary gland lesions are classified as nodular oncocytic hyperplasia, oncocytoma and oncocytic carcinoma. Read More

J Craniomaxillofac Surg 2020 Jun 17;48(6):590-598. Epub 2020 Apr 17.

Department of Oral and Maxillofacial Surgery, Laboratory for Tumor Genetics and Regenerative Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg 20246, Germany.

Objectives: Salivary gland tumors are predominantly benign and frequently localized in the parotid gland (P). The treatment consists primarily of surgical removal; however, the appropriate extent remains a subject of debate. In suitable tumors, superficial parotidectomy (SP) may be substituted for less invasive partial superficial parotidectomy (PSP) (I C). Read More

Br J Radiol 2020 Jul 7;93(1111):20200125. Epub 2020 May 7.

Department of Radiation Oncology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8551, Japan.

Objective: To evaluate the biological effectiveness of dose associated with interruption time; and propose the dose compensation method based on biological effectiveness when an interruption occurs during photon radiation therapy.

Methods: The lineal energy distribution for human salivary gland tumor was calculated by Monte Carlo simulation using a photon beam. The biological dose (D) was estimated using the microdosimetric kinetic model. Read More

Head Neck 2020 06 29;42(6):1305-1307. Epub 2020 Apr 29.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, California, USA.

Background: Telehealth postoperative visits are an attractive strategy to minimize exposure, especially during the SARS-CoV-2 (COVID-19) pandemic. The use of a surgical drain often prevents this minimal-exposure approach in that patients return to the outpatient clinic for drain removal.

Methods And Results: Following unilateral neck dissection, the customary closed-suction drain was replaced with a self-removing, passive drain dressing to facilitate same-day discharge and telehealth postoperative follow-up. Read More

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656720920600. Epub 2020 Apr 20.

Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana.

Background: Epithelial-myoepithelial carcinomas make up less than 0.1% of head and neck malignancies and are regarded as rare, low-grade malignant neoplasms of the salivary gland. They are thought to arise from intercalated ducts with histopathology showing a classic biphasic morphology of an outer layer of myoepithelial cells and inner layer of epithelial cells. Read More

Oral Oncol 2020 Apr 21:104691. Epub 2020 Apr 21.

DeWitt Daughtry Family Department of Surgery, Division of Oral and Maxillofacial Surgery, Section of Head and Neck Surgical Oncology/, Microvascular Reconstructive Surgery, University of Miami, Miller School of Medicine/Jackson Health System, Deering Medical Plaza, 9380 SW 150(th) St #170, Miami, FL 33176, United States. Electronic address:

Background: The presence of synchronous benign and malignant salivary gland neoplasms is very rare. The authors present a previously unreported combination of Secretory Carcinoma (SC) and Warthin's Tumor (WT) within the same parotid gland.

Methods: The patient presented with increasingly painful enlargement of the left parotid gland. Read More

J Clin Med 2020 04 18;9(4). Epub 2020 Apr 18.

Department of Emergency and Organ Transplantation - Section of Pathological Anatomy, University of Bari Aldo Moro, Italy, Piazza G. Cesare, 11, 70124 Bari, Italy.

Aims: To report on the clinico-pathological features of a series of 14 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth.

Materials And Methods: All mucoepidermoid carcinomas diagnosed in the period 1990–2012 were retrieved; the original histological preparations were reviewed to confirm the diagnosis and from selected cases, showing exclusive intra-cystic neoplastic components, additional sections were cut at three subsequent 200 m intervals and stained with Hematoxylin–Eosin, PAS, Mucicarmine and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Additionally, pertinent findings collected from the clinical charts and follow-up data were analyzed. Read More

Medicine (Baltimore) 2020 Apr;99(16):e19739

Department of Hematology.

Rationale: B cell lymphoma can co-occur with multiple myeloma (MM), and the prognosis in this case is usually poor. We propose the combination of CD19-chimeric antigen receptor (CAR) T cells and BCMA-CAR T cells for the treatment of such patients to obtain a superior prognosis.

Patient Concerns: We present a 50-year-old patient with previous B cell lymphoma and subsequent multiple myeloma (MM). Read More

Arkh Patol 2020 ;82(2):43-51

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Ministry of Health of Russia, Moscow, Russia; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

Secretory carcinoma of the salivary gland is a tumor that was first described less than 10 years ago and that mainly occurs in the parotid salivary gland in the elderly. Analyzing the literature over 8 years since the first description of the tumor identifies the main clinical, morphological, and genetic signs of the diagnosis of secretory carcinoma with a focus on the pediatric population. Four new cases of secretory carcinoma of the salivary glands, which have been diagnosed in children of the youngest age encountered in the literature, are also described. Read More

Ann Diagn Pathol 2020 Apr 6;46:151521. Epub 2020 Apr 6.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States of America. Electronic address:

The tumors involving the parotid gland are mainly primary, with metastatic lesions comprising only 5% of malignant salivary gland neoplasms. We are presenting a rare case of metastatic meningioma to the parotid in a 51-year-old male with a past medical history of recurrent atypical meningioma involving the frontal lobe. For the past 1. Read More

MMWR Morb Mortal Wkly Rep 2020 Apr 17;69(15):433-438. Epub 2020 Apr 17.

Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC.

Cancers of the oral cavity and pharynx account for 3% of cancers diagnosed in the United States* each year. Cancers at these sites can differ anatomically and histologically and might have different causal factors, such as tobacco use, alcohol use, and infection with human papillomavirus (HPV) (1). Incidence of combined oral cavity and pharyngeal cancers declined during the 1980s but began to increase around 1999 (2,3). Read More

Shanghai Kou Qiang Yi Xue 2019 Oct;28(5):499-503

Department of General Dentistry,Beijing Stomatological Hospital affiliated to Capital Medical University. Beijing 100006,China.

Purpose: To investigate the expression of rapamycin target protein (mTOR) mRNA and transferrin receptor 1(Tfr1) mRNA in mucoepidermoid carcinoma of parotid gland and its relationship with prognosis.

Methods: From June 2013 to July 2015 in Tangshan Workers' Hospital, 35 patients with mucoepidermoid carcinoma of parotid gland were selected. The relative expression of mTOR and Tfr1 mRNA in mucoepidermoid carcinoma of parotid gland was detected. Read More

Diagn Cytopathol 2020 Jul 9;48(7):604-609. Epub 2020 Apr 9.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, US.

Background: Salivary duct carcinoma (SDC) is an uncommon and highly aggressive primary salivary gland neoplasm. Cytomorphologic features of SDC include cellular smears, nuclear atypia, prominent nucleoli, cribriform and papillary architecture, and background necrosis. The presence of oncocytic features has been described but not adequately characterized in the current literature. Read More

Cancers (Basel) 2020 Apr 3;12(4). Epub 2020 Apr 3.

Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany.

Background: Malignant neoplasms of the salivary glands are rare, and therapeutic options are limited. Results from recently published studies indicate a possible use for checkpoint inhibition in a subset of patients, but there are no established criteria for programme cell death ligand 1 (PD-L1) scoring in salivary gland carcinomas (SGCs).

Methods: In this retrospective study, we present a cohort of 94 SGC patients with full clinical follow-up. Read More

Cytopathology 2020 May;31(3):193-207

Division of Pathology, Department of Pathology and Cytology, Clinical Hospital "Sveti Duh", Zagreb, Croatia.

Warthin's tumour (WT) is a benign epithelial salivary tumour, one type of salivary adenoma. Histologically, WT is structured of two components, epithelial tissue that often lines cystic formations and lymphoid tissue in the tumour stroma. FNA is a reliable diagnostic approach in the diagnosis of salivary gland lesions allowing a highly accurate categorization of benign tumour-like lesions, benign tumours and malignant tumours. Read More

Ocul Oncol Pathol 2020 Mar 20;6(2):138-144. Epub 2019 Sep 20.

Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose: The aim of this study was to assess whether mucoepidermoid carcinoma of the lacrimal sac is a counterpart of gene fusion-related salivary gland mucoepidermoid carcinoma.

Methods: In this retrospective observational case series, pathology records were searched for all cases of lacrimal sac mucoepidermoid carcinoma diagnosed between 1990 and 2018. Data collected included demographics, clinical findings, management, and follow-up. Read More

Int Arch Otorhinolaryngol 2020 Apr 28;24(2):e211-e214. Epub 2020 Jan 28.

Department of Surgery, Aga Khan University Hospital, Karachi, Sindh, Pakistan.

 Tumors of the parotid gland are heterogeneous. The purpose of the drain placement is to evacuate fluid that has a potential to accumulate in the dead space and cause infection after parotidectomy.  To evaluate the factors associated with drain output among patients submitted to parotidectomy. Read More

Int Arch Otorhinolaryngol 2020 Apr 4;24(2):e160-e169. Epub 2019 Nov 4.

Department of Otorhinolaryngology, Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

 The most common site of salivary gland tumors is the parotid gland. Computed tomography (CT), magnetic resonance imaging (MRI), and sonography are imaging modalities to differentiate benign from malignant parotid tumors.  The aim of this study is the evaluation of the diagnostic value of perfusion CT for differentiating histological categorization of benign and malignant parotid tumors. Read More

Georgian Med News 2020 Feb(299):13-21

2PHEE "Kyiv Vedical University", Ukraine.

The purpose of the research is to clarify the diagnostic value of the ultrasound examination method in the diagnosis of tumors of the parotid gland. A clinical examination of 389 patients with tumors and tumor-like neoplasms of the parotid gland was performed. Based on the clinical examination of patients with tumors of the parotid glands, it can be concluded that the ultrasound examination method is highly informative and allows you to study in detail the structure of the tumor and the surrounding soft tissues, which significantly increases its diagnostic value. Read More

Cancer Immunol Immunother 2020 Jul 30;69(7):1363-1373. Epub 2020 Mar 30.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.

Salivary gland carcinomas (SGCs) are rare and can be subdivided into distinct entities, some of which confer a poor prognosis. As targets for effective systemic therapy are warranted, some studies investigated the role of immune-checkpoint proteins PD-L1 and CTLA-4 in SGC. Our study depicts the expression of lymphocyte activation gene 3 (LAG3) in a test cohort and a larger validation cohort, totaling 139 SGCs. Read More

Zhongguo Fei Ai Za Zhi 2020 Mar;23(3):168-175

Department of Thoracic Medicine, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer Hospital, Changsha 410006, China.

Background: Lymphoepithelioma-like carcinoma, an uncommon epithelial tumor, is mostly originated form the nasopharynx and also occurs in foregut-derived organs, such as lung, stomach, salivary gland, and thymus. Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype accounting for around 0.9% of non-small cell lung cancer (NSCLC). Read More

Cancer Radiother 2020 Jun 17;24(3):226-246. Epub 2020 Mar 17.

UT Health HOPE Cancer Center, Tyler, TX 75701, USA.

We report the case of an 84-year-old woman with poorly differentiated non-small cell carcinoma of the right parotid who presented with headache, was found to have a primary right parotid gland cancer as well as metastatic disease, and underwent palliative radiotherapy to the primary site. The patient received no chemotherapy or immunotherapy, but both the primary site and several non-irradiated foci in the lungs regressed or completely resolved. The patient remained free of disease for about one year before progression. Read More

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S42-S45. Epub 2020 Feb 28.

Department of Oral Pathology and Microbiology, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India.

Central intraosseous adenoid cystic carcinoma (ACC) of the mandible, formerly known as cylindroma, is a rare neoplasm with only 47 cases reported in the literature. We present a case of central ACC involving the mandible of a 55-year-old male patient. Read More

Ann R Coll Surg Engl 2020 May 11;102(5):340-342. Epub 2020 Mar 11.

PNS Shifa Hospital, Karachi, Pakistan.

Introduction: Fine-needle aspiration cytology (FNAC) is an important diagnostic tool used preoperatively for the diagnosis of parotid lump. Mucoepidermoid carcinoma comprises 5-10% of all salivary gland tumours. It poses a diagnostic challenge on FNAC with high false negative rate. Read More

Life Sci 2020 May 3;249:117483. Epub 2020 Mar 3.

Nanotechnology and Regenerative Medicine Commercialization Centre (Ltd), London Bioscience Innovation Centre, London, UK.

Head and neck cancer (HNC) constitute 5% of all reported cancers. Among all, the oral cavity cancer is the most frequent type of HNC which accounts for over half of HNC cases. Mouth cancer ranks the sixth leading cause of cancer-related mortality. Read More

Head Neck Pathol 2020 Jun 2;14(2):311-320. Epub 2020 Mar 2.

Department of Laboratory Medicine and Pathobiology, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada.

Next-Generation Sequencing (NGS) is being utilized with increasing frequency in the characterization of salivary gland tumours. The potential scenarios which may be encountered by using this technique in routine practice will be outlined in further text by drawing from our own clinical experience. These include oncocytic mucoepidermoid carcinomas with unusual variant morphology (and negative MAML2 fluorescent in-situ hybridization results), a diagnosis of ameloblastoma changed to adenoid cystic carcinoma (due to MYBL1 fusion presence), a salivary duct carcinoma with an ETV6-NTRK3 fusion (otherwise seen in secretory carcinomas) and novel fusion partners such as EWSR1-BEND2 (otherwise seen in pancreatic neuroendocrine carcinomas). Read More

Stomatologija 2019 ;21(3):92-96

Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences. Nitte University, Deralakatte, Mangalore, 575018 India.

Salivary gland carcinomas are the uncommon and clinically diverse group of neoplasms with mucoepidermoid carcinoma (MEC) being the most common among them. MEC accounts for 5% of all salivary gland tumors. As the name implies, the tumor is composed of both mucus secreting cells and epidermoid type cells in varying proportions. Read More

Cancer Manag Res 2020 11;12:1047-1067. Epub 2020 Feb 11.

Department of Oncology, Medical University in Lublin, Lublin, Poland.

Purpose: Salivary gland neoplasms are rare cancers of the head and neck region. Radical treatment in tumors of large salivary glands is surgery. Adjuvant treatment depends on the presence of risk factors that worsen the prognosis, but the role of these factors in patients treated by surgery with radio- or radiochemotherapy still remains unclear. Read More

PLoS One 2020 21;15(2):e0229311. Epub 2020 Feb 21.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, United States of America.

Glial cell-derived neurotrophic factor (GDNF) is reported to promote the survival of neurons and salivary gland regeneration after radiation damage. This study investigated the effect of GDNF on cell migration, growth, and response to radiation in preclinical models of head and neck squamous cell carcinoma (HNSCC) and correlated GDNF expression to treatment outcomes in HNSCC patients. Our ultimate goal is to determine whether systemic administration of GDNF at high dose is safe for the management of hyposalivation or xerostomia in HNSCC patients. Read More

Nat Commun 2020 02 20;11(1):991. Epub 2020 Feb 20.

Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

Characterizing the complex composition of solid tumors is fundamental for understanding tumor initiation, progression and metastasis. While patient-derived samples provide valuable insight, they are heterogeneous on multiple molecular levels, and often originate from advanced tumor stages. Here, we use single-cell transcriptome and epitope profiling together with pathway and lineage analyses to study tumorigenesis from a developmental perspective in a mouse model of salivary gland squamous cell carcinoma. Read More

J Clin Med 2020 Feb 14;9(2). Epub 2020 Feb 14.

Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.

A preliminary evaluation of the parotid secretion cellular composition in patients with Sjogren's Syndrome (SS) and a diagnostic accuracy assessment of salivary lymphocyte detection and immunophenotyping in Sjogren's Syndrome diagnosis and prognosis were performed. The study included 40 consecutive patients, aged 19-60 years, with parenchymal sialadenitis associated with Sjogren's Syndrome, and 20 healthy donors. The exclusion criteria were exacerbation of sialadenitis, chronic infections, malignant neoplasms, and lymphoproliferative diseases. Read More