19,892 results match your criteria Salivary Gland Neoplasms


Necrotizing sialometaplasia can hide the presence of salivary gland tumors. A case series.

Oral Dis 2019 Feb 18. Epub 2019 Feb 18.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Objective: Necrotizing sialometaplasia (NS) is an uncommon benign process which affects minor and, more rarely, major salivary glands. While self-limiting, the condition might be clinically and histologically mistaken for malignancy. Furthermore, NS may accompany neoplasms. Read More

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http://doi.wiley.com/10.1111/odi.13066
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http://dx.doi.org/10.1111/odi.13066DOI Listing
February 2019
5 Reads

Adjuvant androgen deprivation therapy for poor-risk, androgen receptor-positive salivary duct carcinoma.

Eur J Cancer 2019 Feb 13;110:62-70. Epub 2019 Feb 13.

Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, the Netherlands. Electronic address:

Aim: Salivary duct carcinoma (SDC), an aggressive subtype of salivary gland cancer, is androgen receptor (AR)-positive in 67-96% of cases. In patients with locally recurrent and metastatic (R/M) AR-positive SDC, androgen deprivation therapy (ADT) has an overall response rate of 18-64.7%. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.035DOI Listing
February 2019
1 Read

Two case reports of synchronous unilateral pleomorphic adenoma and cystadenolymphoma of the parotid gland with literature review.

J Ultrason 2018 ;18(75):369-373

Department of Otorhinolaryngology, Head and Neck Surgery , Klinikum Augsburg, Augsburg , Germany.

Synchronous unilateral tumors in the parotid glands account for less than 5-10% of all salivary gland neoplasms. Mostly these are cystadenolymphomas, but tumors of different histological types can be found as well. In these cases it is often pleomorphic adenoma in combination with cystadenolymphoma. Read More

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http://dx.doi.org/10.15557/JoU.2018.0055DOI Listing
January 2018
1 Read

Induction of squamous cell carcinoma after MAP3K8 overexpression in murine salivry gland epithelial cells.

Head Neck 2019 Feb 5. Epub 2019 Feb 5.

Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Salivary gland neoplasms are relatively rare and comprise only 1%-4% of all human neoplasms. Salivary gland neoplasms also show an extremely wide range of morphological diversity. Currently, the genetic alterations and corresponding molecular mechanisms underlying salivary gland neoplasms development remain largely unknown. Read More

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http://dx.doi.org/10.1002/hed.25411DOI Listing
February 2019

IgG4-related disease: what a hematologist needs to know.

Haematologica 2019 Jan 31. Epub 2019 Jan 31.

Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, Canada.

IgG4-related disease is a fibroinflammatory condition that can affect nearly any organ system. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal fibrosis and tubulointerstitial nephritis. This review focuses on the hematological manifestations of IgG4-related disease, including lymphadenopathy, eosinophilia, and polyclonal hypergammaglobulinemia. Read More

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http://dx.doi.org/10.3324/haematol.2018.205526DOI Listing
January 2019
2 Reads

Computed tomographic features of adenoid cystic carcinoma in the palate.

Cancer Imaging 2019 Jan 31;19(1). Epub 2019 Jan 31.

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth Peoples Hospital, College of Stomatology Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.

Background: To evaluate the computed tomographic features and create a prediction model for clinical diagnosis of adenoid cystic carcinoma (ACC) in the palate with intact mucosa.

Methods: From March 2016 to May 2018, 102 patients with palatal tumors and intact mucosa, including 28 patients with a pathological diagnosis of ACC after surgery, were enrolled in this study. The patients' clinical symptoms, computed tomographic features and pathological diagnoses were recorded and analyzed. Read More

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https://cancerimagingjournal.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s40644-019-0190-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357373PMC
January 2019
3 Reads

Ectopic pleomorphic adenoma on subcutaneous plane of the cheek.

Arch Craniofac Surg 2019 Feb 1. Epub 2019 Feb 1.

Department of Plastic and Reconstructive Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.

Pleomorphic adenoma is the most common benign tumor of the salivary gland. Pleomorphic adenoma occurs most commonly in the parotid gland but it may involve other salivary gland such as submandible or lingual. We report an ectopic pleomorphic adenoma in the subcutaneous layer of the face. Read More

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http://e-acfs.org/journal/view.php?doi=10.7181/acfs.2018.019
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http://dx.doi.org/10.7181/acfs.2018.01949DOI Listing
February 2019
5 Reads

Prevalence of Fatigue in Head and Neck Cancer Survivors.

Ann Otol Rhinol Laryngol 2019 Jan 30:3489419826138. Epub 2019 Jan 30.

2 Supportive Care Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Introduction:: In head and neck cancer (HNC) patients, fatigue is present throughout the course of treatment and during follow-up. There are limited data about the prevalence and factors associated with fatigue in HNC survivors. The objectives of this study were to assess the prevalence of fatigue and its interference with daily life activities and examine the association between fatigue and gender, age, primary tumour site, Human Papillomavirus (HPV) status, previous oncologic therapy, and time since end of treatment. Read More

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http://dx.doi.org/10.1177/0003489419826138DOI Listing
January 2019
2 Reads

Risk-based Stratification of Salivary Gland Lesions on Cytology: An Institutional Experience.

Iran J Pathol 2018 17;13(2):220-228. Epub 2018 Jul 17.

Dept. of Pathology, Integral Institute of Medical Sciences and Research, Lucknow, India.

Background & Objective: Fine needle aspiration cytology (FNAC) of salivary gland lesions is an accepted and useful diagnostic tool to differentiate between benign and malignant lesions. Majority of the neoplasms are benign, and specific diagnosis on cytology can be made in most of the cases. However, the utility is limited by the overlapping and heterogeneous morphological features of benign and malignant neoplasms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339488PMC

Assessment of and rearrangements in breast adenomyoepitheliomas.

NPJ Breast Cancer 2019 18;5. Epub 2019 Jan 18.

1Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA.

Breast adenomyoepitheliomas (AMEs) are rare epithelial-myoepithelial neoplasms that may occasionally produce myxochondroid matrix, akin to pleomorphic adenomas (PAs). Regardless of their anatomic location, PAs often harbor rearrangements involving or . We have recently shown that the repertoire of somatic genetic alterations of AMEs varies according to their estrogen receptor (ER) status; whilst the majority of ER-positive AMEs display mutually exclusive or hotspot mutations, up to 60% of ER-negative AMEs harbor concurrent Q61 hotspot mutations and mutations affecting either or . Read More

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http://dx.doi.org/10.1038/s41523-018-0101-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338730PMC
January 2019
2 Reads

Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.

Nat Commun 2019 01 21;10(1):368. Epub 2019 Jan 21.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Krankenhausstr. 8-10, 91054, Erlangen, Germany.

The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins of which some are specifically expressed at high levels in the salivary glands and constitute major components of saliva. Here we report on recurrent rearrangements [t(4;9)(q13;q31)] in AciCC that translocate active enhancer regions from the SCPP gene cluster to the region upstream of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) at 9q31. Read More

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http://dx.doi.org/10.1038/s41467-018-08069-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341107PMC
January 2019
2 Reads

[Terebrant basal cell carcinoma].

Pan Afr Med J 2018 30;30:300. Epub 2018 Aug 30.

Service de Dermatologie-Vénérologie, Hôpital d'Instruction Mohammed V, Rabat, Maroc.

Basal cell carcinoma (BCC) is the most frequent skin cancer. It never affects the mucosa. It is characterized by a local malignancy with an extremely rare risk of developing distant metastasis and the lowest mortality. Read More

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http://www.panafrican-med-journal.com/content/article/30/300
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http://dx.doi.org/10.11604/pamj.2018.30.300.16224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320449PMC
January 2019
3 Reads

The diagnostic performance of ultrasonography and computerized tomography in differentiating superficial from deep lobe parotid tumours.

Clin Otolaryngol 2019 Jan 12. Epub 2019 Jan 12.

Department of Otolaryngology Head and Neck Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan (R.O.C.).

Objectives: To validate and compare ultrasound (US) versus computerized tomography (CT) criteria in the localisation of superficial/deep lobe tumours of the parotid gland.

Design And Setting: This was a retrospective study of diagnostic tests performed from January 2008 to June 2017.

Participants: We included adult patients who were referred for a neck ultrasonography examination due to parotid tumours, and who subsequently underwent parotid surgery. Read More

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http://dx.doi.org/10.1111/coa.13289DOI Listing
January 2019
1 Read

Postoperative radiotherapy for mucoepidermoid carcinoma of the major salivary glands: long-term results of a single-institution experience.

Radiat Oncol J 2018 Dec 31;36(4):317-324. Epub 2018 Dec 31.

Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: This study aimed to evaluate the long-term survival outcomes and prognostic factors that affect the clinical outcomes of patients who underwent surgery and postoperative radiotherapy for major salivary gland mucoepidermoid carcinoma (MEC).

Materials And Methods: We retrospectively reviewed the clinical data of 44 patients who underwent surgery followed by radiotherapy for primary MEC of the major salivary glands between 1991 and 2014. The median follow-up period was 9. Read More

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http://dx.doi.org/10.3857/roj.2018.00409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361245PMC
December 2018

[Clinical pathologic analysis on 3 724 cases of salivary gland tumors].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Jan;54(1):10-16

Department of Pathology, Hospital of Stomatology, Jilin University, Changchun 130021, China.

To investigate the incidence and proportion of salivary gland tumors in order to provide new thinking for clinical diagnosis and treatment. Collected 3 724 cases salivary gland tumors diagnosed by Pathology Department of Hospital of Stomatology, Jilin University from January 1961 to December 2016. The pathological diagnosis referred to the fourth edition of head and neck-salivary gland tumor histopathological classification standard of WHO. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.01.003DOI Listing
January 2019
2 Reads

Radiotherapy for parapharyngeal space tumors.

Am J Otolaryngol 2018 Dec 21. Epub 2018 Dec 21.

Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

A wide variety of tumors, both benign and malignant, occur in the parapharyngeal space. Depending on histology and extent, treatment may include surgery and/or radiotherapy (RT). Herein we discuss the role of RT in the management of some of the more commonly encountered neoplasms, including salivary gland tumors, paragangliomas, schwannomas, and soft-tissue sarcomas. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.12.010DOI Listing
December 2018
1 Read

Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors.

Authors:
E V Kochurova

Bull Exp Biol Med 2019 Jan 8;166(3):383-385. Epub 2019 Jan 8.

I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia.

The benign and malignant neoplasms in parotid gland have similar clinical presentations despite different tumor growth rates. The study compared the clinical and morphological data as well as the results of ELISA for MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 in salivary fluid yielded during primary examination of the patients with pleomorphic adenoma and adenocarcinoma of parotid gland. The examined biomarkers detected in salivary fluid in patients with various cancer types differed significantly (p≤0. Read More

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http://dx.doi.org/10.1007/s10517-019-04355-wDOI Listing
January 2019
1 Read

Pediatric follicular lymphoma of the parotid gland.

Arch Craniofac Surg 2018 Dec 27;19(4):279-282. Epub 2018 Dec 27.

Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.

Primary malignant lymphoma rarely presents as a mass in the salivary gland. It accounts for about 1% of salivary gland tumors. The lymphomas of the parotid gland are mainly non-Hodgkin's lymphoma of B-cell follicular type. Read More

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http://dx.doi.org/10.7181/acfs.2018.02075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325339PMC
December 2018
1 Read

Intraductal Carcinoma of Salivary Glands Harboring TRIM27-RET Fusion with Mixed Low Grade and Apocrine Types.

Head Neck Pathol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pathology and Laboratory Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, L25, Cleveland, OH, 44195, USA.

Intraductal carcinomas (IDCs) of salivary gland are rare neoplasms. Here, we report a case of IDCs harboring TRIM27-RET fusion with mixed low grade and apocrine types. A 79-year-old male presented with slowly-growing left parotid mass for 2. Read More

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http://link.springer.com/10.1007/s12105-018-0996-1
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http://dx.doi.org/10.1007/s12105-018-0996-1DOI Listing
January 2019
1 Read

Role of fine-needle aspiration in post liver transplant patients: A clinical/cytological review.

Diagn Cytopathol 2018 Dec 28. Epub 2018 Dec 28.

Department of Pathology, Rush University Medical Center, Chicago, Illinois.

Background: Fine-needle aspiration (FNA) of superficial and deep-seated lesions has been used with high sensitivity and specificity in the diagnosis of neoplastic and nonneoplastic lesions. However, literature of FNA in posttransplant patients is sparse, especially in postliver transplant. We undertook a retrospective study to evaluate the utility of FNA in the clinical management of post liver transplant patients. Read More

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http://dx.doi.org/10.1002/dc.24133DOI Listing
December 2018

TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.

J Clin Oncol 2019 Feb 28;37(6):513-524. Epub 2018 Dec 28.

University of Texas Southwestern Medical Center/Children's Health, Dallas, TX.

Chromosomal translocations involving the NTRK1, NTRK2, and NTRK3 genes (TRK fusions), which encode the neurotrophin tyrosine kinase receptors TRKA, TRKB, and TRKC, can result in constitutive activation and aberrant expression of TRK kinase. Certain cancers almost universally harbor TRK fusions, including infantile fibrosarcoma, cellular congenital mesoblastic nephroma, secretory breast cancer, and mammary analog secretory carcinoma of the salivary gland. TRK fusions have also been identified at lower frequencies across a broad range of other pediatric cancers, including undifferentiated sarcomas, gliomas, papillary thyroid cancers, spitzoid neoplasms, inflammatory myofibroblastic tumors, and acute leukemias. Read More

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http://dx.doi.org/10.1200/JCO.18.00573DOI Listing
February 2019
1 Read

Review of 109 cases of primary malignant orofacial lesions seen at a Nigerian Tertiary Hospital.

Niger Postgrad Med J 2018 Oct-Dec;25(4):246-251

Department of Oral and Maxillofacial Surgery/Oral Pathology, Obafemi Awolowo University, Ile-Ife, Nigeria.

Background: Orofacial malignancy is a growing health issue common in developing regions of the world. Presentation patterns are myriad with geographic variations. Advanced stage owing to late presentation constitutes a significant public health burden. Read More

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http://dx.doi.org/10.4103/npmj.npmj_115_18DOI Listing
December 2018
1 Read

An unusual case of intraosseous mucoepidermoid carcinoma of the mandible: A case report and literature review.

Medicine (Baltimore) 2018 Dec;97(51):e13691

Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province.

Rationale: Mucoepidermoid carcinoma (MEC) is the most common primary salivary gland malignancy. Ectopic MEC can occur in any part of the body, however, only 2% to 4% of MEC could be detected in the jaw, which is named intraosseous mucoepidermoid carcinoma (IMC). IMC is usually a low-grade carcinoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320197PMC
December 2018

Metachronous bilateral multifocal nodular oncocytic hyperplasia of the parotid gland.

J Stomatol Oral Maxillofac Surg 2018 Dec 16. Epub 2018 Dec 16.

University of Health Sciences, Ankara Application and Research Hospital, Department of Nuclear Medicine, Ankara, Turkey.

Multifocal nodular oncocytic hyperplasia (MNOH) is a rare lesion of the parotid gland and bilateral cases are extremely rare. We report the case of a 69-year-old woman who was operated from MNOH 10 years ago and the bilateralism of the case appeared 10 years later making the case metachronous. Read More

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http://dx.doi.org/10.1016/j.jormas.2018.12.009DOI Listing
December 2018

Adenoid cystic carcinoma in ventricle of larynx: An interesting case.

Medicine (Baltimore) 2018 Dec;97(50):e13622

Department of Otolaryngology, First Affiliated Hospital, College of Medicine, Zhe Jiang University, Hangzhou.

Rationale: Adenoid cystic carcinomas (ACCs) are malignant tumors and occur in the major and the minor salivary glands. ACCs are rare in the larynx.

Patient Concerns: A 55-year-old female patient who presented with a 12 months history of paraesthesia pharynges and hoarseness for 4 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000013622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320204PMC
December 2018
2 Reads

[Functional parotid surgery for removal of benign parotid tumors].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1810-1812

Department of Stomatology, Tongji Hospital, Tongji University.

To evaluate the effect of the application of functional parotid surgery for removal of benign parotid tumors and the prevention of Frey syndrome. One hundred and fifty-six cases with benign tumor were underwent functional regional parotidectomy. All tumors were smaller than 4 cm in diameter. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.23.010DOI Listing
December 2018
4 Reads

AHNS series: Do you know your guidelines? Diagnosis and management of salivary gland tumors.

Head Neck 2019 Feb 13;41(2):269-280. Epub 2018 Dec 13.

Otolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania.

This article is the next installment of the series "Do you know your guidelines" presented by the Education Committee of the American Head and Neck Society. Guidelines for the workup and management of tumors of the major and minor salivary glands are reviewed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25499
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http://dx.doi.org/10.1002/hed.25499DOI Listing
February 2019
7 Reads

Review of the Major and Minor Salivary Glands, Part 2: Neoplasms and Tumor-like Lesions.

J Clin Imaging Sci 2018 15;8:48. Epub 2018 Nov 15.

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York, USA.

The salivary glands are small structures in the head and neck, but can give rise to a wide variety of benign and malignant pathology. When this occurs, patients may present with palpable swelling, although it is quite common that they are asymptomatic and a salivary gland mass was discovered as an incidental finding on imaging performed for another reason. It is, therefore, critical that radiologists pay careful attention to the salivary glands and have working knowledge of the key differentiating features of the most common neoplastic and nonneoplastic etiologies of salivary gland masses. Read More

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http://www.clinicalimagingscience.org/text.asp?2018/8/1/48/2
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http://dx.doi.org/10.4103/jcis.JCIS_46_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251244PMC
November 2018
6 Reads

[Clinicopathologic and molecular features of myoepithelial tumors of salivary glands].

Zhonghua Bing Li Xue Za Zhi 2018 Dec;47(12):936-940

Department of Pathology, General Hospital of Eastern Theater Command, Nanjing 210002, China.

To investigate the clinicopathological, and molecular characteristics of myoepithelial tumors (MTs) of salivary glands. A total of 37 MTs cases including 13 malignant epithelial tumors (MMTs) and 24 benign epithelial tumors (BMTs) of salivary glands were identified from the archives of the Department of Pathology, General Hospital of Eastern Theater Command, dating from 2006 to 2016. Clinical features, histological patterns, immunohistochemical characteristics and status of EWSR1 gene rearrangement by fluorescence in situ hybridization (FISH) analysis were reviewed in all cases. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.12.008DOI Listing
December 2018
2 Reads

Salivary gland tumors in a Brazilian population: A 20-year retrospective and multicentric study of 2292 cases.

J Craniomaxillofac Surg 2018 Dec 26;46(12):2227-2233. Epub 2018 Sep 26.

Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte-UFRN, Av. Senador Salgado Filho, 1787-Lagoa Nova, Natal, RN, 59056-000, Brazil. Electronic address:

Purpose: Neoplasms of the salivary glands comprise more than thirty subtypes of lesions with various clinical behaviors. The present study aimed to describe the incidence and main features of salivary gland tumors in Brazil.

Material And Methods: A retrospective descriptive cross-sectional study was performed (1997-2017). Read More

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http://dx.doi.org/10.1016/j.jcms.2018.09.028DOI Listing
December 2018
2 Reads

Histological Subtypes and Clinical Behavior Evaluation of Salivary Gland Tumors.

Acta Med Port 2018 Nov 30;31(11):641-647. Epub 2018 Nov 30.

Department of Pathology. Centro Hospitalar São João. Porto. Unit of Pathology and Oncology. Department of Pathology. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

Introduction: Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate.

Material And Methods: We performed a retrospective study of all salivary gland tumors diagnosed and treated at the Centro Hospitalar São João, Porto, between 2005 and 2015. Histological re- evaluation was performed in all cases and patient files were reviewed and both clinical and follow-up data were collected. Read More

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http://dx.doi.org/10.20344/amp.9023DOI Listing
November 2018
17 Reads

An Unusual Case Report: Occurrence of Renal Cell Carcinoma, Basal Cell Carcinoma and Chronic Lymphocytic Leukemia in a Case of Papillary Thyroid Carcinoma Treated with Radioactive Iodine.

Iran J Med Sci 2018 Nov;43(6):659-663

Department of Hematology and Medical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran.

The standard therapy for thyroid cancer is total or near total thyroidectomy, followed by the administration of radioactive iodine for remnant ablation or residual disease. Patients with radioiodine therapy are predisposed to second malignant neoplasms in organs such as central nervous system (CNS), breast, prostate, kidney, bone marrow, salivary gland, and digestive tract. Exposure to carcinogen including occupational and therapy related hazard, aging and genetic susceptibility are other causes of second primary cancers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230934PMC
November 2018
3 Reads

Acinic cell carcinoma of parotid gland with cavernous sinus metastasis: A case report.

J Cancer Res Ther 2018 Oct-Dec;14(6):1428-1430

Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.

Acinic cell carcinoma (AciCC) is a low-grade malignancy which rarely metastasizes to bone or cavernous sinuses. A 62-year-old male patient, previously treated for AciCC of right parotid with surgery and local radiotherapy, presented 10 years later with progressive visual impairment and restriction of ocular movements. Magnetic resonance imaging of the head and orbit showed an expansile lobulated mass with heterogeneous signal intensity in bilateral cavernous sinus with encasement of the internal carotid artery on both sides. Read More

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http://dx.doi.org/10.4103/0973-1482.192850DOI Listing
February 2019
12 Reads

Mucoepidermoid carcinoma of the minor salivary gland: Presenting as ranula.

J Cancer Res Ther 2018 Oct-Dec;14(6):1418-1421

Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Hyderabad, Telangana, India.

Malignant tumors of the salivary gland are rare, clinically diverse group of neoplasms, among which mucoepidermoid carcinomas (MECs) are reported to be most frequently occurring epithelial carcinomas. MEC at times misleads the clinician because of its atypical location and innocent appearance. Here, we report a case of low-grade MEC in a 70-year-old female patient in the floor of the mouth mimicking as ranula clinically. Read More

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http://www.cancerjournal.net/preprintarticle.asp?id=204884
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http://dx.doi.org/10.4103/0973-1482.204884DOI Listing
February 2019
13 Reads

Epidemiology of salivary gland tumours in an Eastern Caribbean nation: A retrospective study.

Ann Med Surg (Lond) 2018 Dec 8;36:148-151. Epub 2018 Nov 8.

Department of Clinical Surgical Science, University of the West Indies, St. Augustine, Trinidad and Tobago.

Objective: The epidemiology of the salivary glands tumour is not well documented in the Caribbean countries. Therefore, the aim of this study is to determine the local trend of salivary gland tumours with a review of current diagnostic techniques.

Design & Methods: Retrospective data was collected from the electronic database at the Pathology department of the San Fernando Teaching Hospital between the periods January 2005 to June 2015. Read More

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http://dx.doi.org/10.1016/j.amsu.2018.10.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240702PMC
December 2018
3 Reads

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.

Head Neck Pathol 2018 Nov 22. Epub 2018 Nov 22.

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

Head and neck pathology present a unique set of challenges including the morphological diversity of the neoplasms and presentation of metastases of unknown primary origin. The detection of human papillomavirus and Epstein-Barr virus associated with squamous cell carcinoma and newer entities like HPV-related carcinoma with adenoid cystic like features have critical prognostic and management implications. In salivary gland neoplasms, differential diagnoses can be broad and include non-neoplastic conditions as well as benign and malignant neoplasms. Read More

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http://dx.doi.org/10.1007/s12105-018-0988-1DOI Listing
November 2018
10 Reads

Body Mass Index and Parotidectomy Outcomes.

J Craniofac Surg 2019 Jan;30(1):e54-e58

Department of Otolaryngology, Loyola University Medical Center, Maywood, IL.

Multiple specialties have demonstrated increased risk of certain postoperative complications in patients with an increased body mass index (BMI). The goal of this study was to understand the outcomes of patients undergoing parotidectomy with an increased BMI and to identify any other patient risk factors for postoperative complications. This study was a retrospective chart review of 432 patients. Read More

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http://Insights.ovid.com/crossref?an=00001665-900000000-9521
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http://dx.doi.org/10.1097/SCS.0000000000004973DOI Listing
January 2019
5 Reads

PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms.

J Pathol Transl Med 2019 Jan 14;53(1):23-30. Epub 2018 Nov 14.

Department of Pathology, National Cancer Center, Goyang, Korea.

Background: Recent findings in molecular pathology suggest that genetic translocation and/oroverexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. Weinvestigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues.

Methods: A total of 113 cases of surgically resected salivary gland neoplasms at the NationalCancer Center from January 2007 to March 2017 were identified. Read More

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http://www.jpatholtm.org/journal/view.php?doi=10.4132/jptm.2
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http://dx.doi.org/10.4132/jptm.2018.10.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344797PMC
January 2019
12 Reads

Expression of EpCAM in adenoid cystic carcinoma.

Pathology 2018 Dec 30;50(7):737-741. Epub 2018 Oct 30.

Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

The mutational landscape of adenoid cystic carcinoma (ACC) is currently being revealed, but further studies are needed to identify biomarkers as therapeutic targets or prognostic factors of ACC. In this study, we investigated the expression of epithelial cell adhesion molecule (EpCAM) in ACCs. We retrospectively collected 83 cases of surgically resected ACCs. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.08.013DOI Listing
December 2018

CRTC1-MAML2 fusion in mucoepidermoid carcinoma of the breast.

Histopathology 2019 Feb 5;74(3):463-473. Epub 2018 Dec 5.

Department of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA.

Aims: Mucoepidermoid carcinomas (MEC) are the most common malignant neoplasms of salivary glands, but are uncommon in other sites. Salivary gland MEC are most frequently associated with CRTC1-MAML2 translocations. Exceedingly rare MEC of the breast demonstrate a basal-like and often triple (oestrogen and progesterone receptor, HER2)-negative immunophenotype, with a single case previously reported to show MAML2 rearrangement, although the fusion partner was not known. Read More

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http://doi.wiley.com/10.1111/his.13779
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http://dx.doi.org/10.1111/his.13779DOI Listing
February 2019
3 Reads
3.453 Impact Factor

Retrospective assessment of the effectiveness of the Milan system for reporting salivary gland cytology: A systematic review and meta-analysis of published literature.

Diagn Cytopathol 2019 Feb 29;47(2):67-87. Epub 2018 Oct 29.

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania.

Introduction: Fine needle aspiration (FNA) has been widely utilized in establishing the nature of salivary gland lesions and guiding the clinical management. This study aimed to determine the accuracy of FNA in detecting salivary gland neoplasms and malignancies, employing the "Milan System for Reporting Salivary Gland Cytopathology" (MSRSGC).

Method: A systematic search was conducted. Read More

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http://doi.wiley.com/10.1002/dc.24097
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http://dx.doi.org/10.1002/dc.24097DOI Listing
February 2019
1 Read

Diagnostic Accuracy of Fine Needle Aspiration Cytology in Lesions of Oral Cavity and Salivary Glands: A Clinico-Pathological Study.

Open Dent J 2018 28;12:782-790. Epub 2018 Sep 28.

Department of Pathology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India.

Objective: Fine Needle Aspiration Cytology (FNAC) is a rapid, reliable and safe diagnostic tool used for various lesions of the oral cavity and salivary glands. The present study was undertaken to categorize the cytomorphology of the oral cavity and salivary gland lesions on FNAC and to assess the accuracy of FNAC in arriving at a diagnosis.

Materials And Methods: A prospective study on oral cavity swellings and salivary gland aspirates was done during a 2 year period from August 2015 to July 2017 in which a total of 70 FNAC's were performed. Read More

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http://benthamopen.com/FULLTEXT/TODENTJ-12-782
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http://dx.doi.org/10.2174/1745017901814010782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182874PMC
September 2018
23 Reads

A comparison study of the reporting systems for salivary gland fine needle aspirations: Are they really different?

Diagn Cytopathol 2018 Oct;46(10):859-863

Unit of Molecular Pathology, IPATIMUP, Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal.

Background: Recently a new system for reporting salivary gland fine-needle aspiration (FNA) cytology was proposed, the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). Herein, we evaluated diagnostic accuracy of salivary gland FNA, comparing the system previously used in our hospital with the Milan system.

Methods: Salivary gland specimens obtained between 2011 and 2017 were reclassified according to MSRSGC. Read More

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http://doi.wiley.com/10.1002/dc.24037
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http://dx.doi.org/10.1002/dc.24037DOI Listing
October 2018
13 Reads

Abnormal activation of the Akt signaling pathway in adenoid cystic carcinoma.

Eur Arch Otorhinolaryngol 2018 Dec 26;275(12):3039-3047. Epub 2018 Oct 26.

Cell Culture Laboratory, School of Dentistry, Federal University of Pará (UFPA), Belém, PA, Brazil.

Purpose: Adenoid cystic carcinoma (ACC) is an intriguing lesion because it shows a slow growth in the beginning, but a late poor prognosis due to perineural invasion, metastasis and recurrence. This study aimed to investigate whether Akt signaling would be deregulated in adenoid cystic carcinoma and its consequence in the expression of associated proteins.

Methods: The expression of the Akt, p-Akt, NFκB, β-catenin, cyclin D1 and COX-2 was assessed by immunohistochemistry in 10 cases of ACC, 17 cases of pleomorphic adenoma (PA), and 7 cases of normal salivary gland (NSG). Read More

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http://link.springer.com/10.1007/s00405-018-5182-2
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http://dx.doi.org/10.1007/s00405-018-5182-2DOI Listing
December 2018
11 Reads

Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas.

Eur Arch Otorhinolaryngol 2018 Dec 25;275(12):3075-3082. Epub 2018 Oct 25.

Oral Pathology Post-Graduation Program, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande Do Norte, 59056-000, Brazil.

Purpose: To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.

Methods: Twenty cases of pleomorphic adenomas and 20 cases of adenoid cystic carcinomas were evaluated for the immunohistochemical expression of matrix metalloproteinases-2, -7, -9, and -26 and tissue inhibitors-1 and -2 in tumor parenchyma.

Results: Most pleomorphic adenomas and adenoid cystic carcinomas showed high expression of matrix metalloproteinases and tissue inhibitors, predominantly located in the tumor cells. Read More

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http://link.springer.com/10.1007/s00405-018-5176-0
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http://dx.doi.org/10.1007/s00405-018-5176-0DOI Listing
December 2018
9 Reads

Parapharyngeal Space Tumor: Submandibular Approach Without Mandibulotomy.

J Maxillofac Oral Surg 2018 Dec 27;17(4):616-624. Epub 2018 Jun 27.

Department of Head and Neck Surgery, Instituto Nacional de Cancerologia, Av. San Fernando #22, Col. Sección XVI, Tlalpan, 14080 Mexico, D.F. Mexico.

Introduction: Among all head and neck tumors, only 0.5% occur in the parapharyngeal space and 80% are benign tumors. Surgery is the cornerstone of treatment. Read More

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http://link.springer.com/10.1007/s12663-018-1133-0
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http://dx.doi.org/10.1007/s12663-018-1133-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181834PMC
December 2018
10 Reads

Potential therapeutic effects of induced pluripotent stem cells on induced salivary gland cancer in experimental rats.

Biotech Histochem 2018 Oct 19:1-8. Epub 2018 Oct 19.

c Oral & Maxillofacial Pathology , Faculty of Dentistry, Cairo University , Cairo , Egypt.

Salivary gland neoplasms exhibit complex histopathology in a variety of tumor types and treatment options depend largely on the stage of the cancer. Induced pluripotent stem cells (iPS) have been investigated for treating induced salivary gland cancer and for restoring salivary gland function. We investigated iPS treatment for salivary gland cancer both in vitro and in vivo. Read More

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https://www.tandfonline.com/doi/full/10.1080/10520295.2018.1
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http://dx.doi.org/10.1080/10520295.2018.1508747DOI Listing
October 2018
16 Reads
1.444 Impact Factor

An Unusual Salivary Gland Tumor Mimicking Papillary Thyroid Carcinoma: Mammary Analog Secretory Carcinoma.

Front Endocrinol (Lausanne) 2018 25;9:555. Epub 2018 Sep 25.

Department of Pathology, University Health Network, Toronto, ON, Canada.

Thyroid tumors usually present as masses in the thyroid gland. While the majority of these tumors represent neoplasms of thyroid tissues, mainly of follicular epithelial cell differentiation, the differential diagnosis includes other lesions, such as C cell neoplasms (medullary thyroid carcinoma), intrathyroidal parathyroid, or thymic tumors, soft tissue tumors, and hematologic neoplasms as well as metastatic malignancies. Rare tumors are of salivary gland types. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00555
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http://dx.doi.org/10.3389/fendo.2018.00555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178136PMC
September 2018
6 Reads

Adenocarcinoma, Not Otherwise Specified, Arising in Accessory Lacrimal Gland: A Diagnostic Challenge.

Ocul Oncol Pathol 2018 Sep 12;4(2):67-72. Epub 2017 Aug 12.

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, New York, NY, USA.

Neoplasms arising in accessory lacrimal glands are rare. We describe a 33-year-old man with adenocarcinoma arising in the left lower eyelid accessory lacrimal gland. Microscopic evaluation demonstrated an infiltrative neoplasm composed of mildly to moderately pleomorphic cells with abundant eosinophilic cytoplasm and focal intracytoplasmic vacuoles, arranged predominantly in ductules. Read More

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http://dx.doi.org/10.1159/000478730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167685PMC
September 2018
1 Read

Nodular fasciitis of the parotid gland: A challenging diagnosis on FNA.

Cancer Cytopathol 2018 Oct 12;126(10):872-880. Epub 2018 Oct 12.

Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland.

Background: Nodular fasciitis (NF) is a clonal, self-limited proliferation that has only rarely been described in the parotid gland. Because of its potential to mimic benign and malignant parotid neoplasms clinically, radiographically, and cytomorphologically, NF is often managed with unnecessary surgery, which is associated with a risk for significant surgical complications. The purpose of this study is to present the clinical and cytomorphologic findings for NF of the parotid gland by fine-needle aspiration (FNA). Read More

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http://doi.wiley.com/10.1002/cncy.22049
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http://dx.doi.org/10.1002/cncy.22049DOI Listing
October 2018
3 Reads