168,946 results match your criteria Saline Systems [Journal]


Evaluation of Pulmonary Toxicity of Nanoparticles by Bronchoalveolar Lavage.

Methods Mol Biol 2019 ;1894:313-322

Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.

Nanoparticles can enter the body via the lungs, the digestive tract, and the skin. The pulmonary effects of nanoparticles and the underlying mechanisms may be investigated by histopathological examination, immunostaining, bronchoalveolar lavage (BAL), and so on. BAL is a simple, fast, and inexpensive method that is commonly used to investigate the immune cells and acellular components in the lungs, which reflect the health state of the lungs. Read More

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January 2019

Allelopathic effects of Canada goldenrod leaf extracts on the seed germination and seedling growth of lettuce reinforced under salt stress.

Ecotoxicology 2018 Dec 13. Epub 2018 Dec 13.

Institute of Environment and Ecology, Academy of Environmental Health and Ecological Security & School of the Environment and Safety Engineering, Jiangsu University, 212013, Zhenjiang, P. R. China.

Allelopathic effects on the seed germination and seedling growth of the natives play a crucial role in the successful invasion of numerous invaders. Meanwhile, soil salinity is an emerging driver of the spread of many invaders, especially in the colonization of saline habitats. Thus, the allelopathic effects of the invaders on the seed germination and seedling growth of the natives may be altered or even reinforced under salt stress. Read More

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December 2018

Efficacy of SMTP-7, a small-molecule anti-inflammatory thrombolytic, in embolic stroke in monkeys.

Pharmacol Res Perspect 2018 Dec 5;6(6):e00448. Epub 2018 Dec 5.

Department of Applied Biological Science Tokyo Noko University (Tokyo University of Agriculture and Technology) Tokyo Japan.

SMTP-7 ( triprenyl phenol-7) is a small molecule that promotes thrombolysis and suppresses inflammation possibly through plasminogen modulation and soluble epoxide hydrolase (sEH) inhibition, respectively. Here, we demonstrate an efficacy of SMTP-7 in a severe embolic stroke model in monkeys. The middle cerebral artery was embolized by an autologous blood clot. Read More

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December 2018

Functional changes of airway epithelial cells and mitochondria in rat models of asthenic lung and phlegm blocking combined with cough variant asthma.

Exp Ther Med 2018 Dec 15;16(6):5021-5024. Epub 2018 Oct 15.

Pneumology Department, The Affiliated Traditional Medical Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, P.R. China.

The aim of this study was to investigated the functional changes of airway epithelial cells and mitochondria in rat models of asthenic lung and phlegm blocking combined with cough variant asthma (CVA). Sixteen Sprague-Dawley rats were randomly divided into two groups: Control and model group, with 8 rats in each group. On the basis of the CVA rat model induced and sensitized by ovalbumin and aluminum hydroxide, the rat models with asthenic lung and phlegm blocking combined with CVA were established via smoking stimulation. Read More

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December 2018

Activation of astrocytes and expression of inflammatory cytokines in rats with experimental autoimmune encephalomyelitis.

Exp Ther Med 2018 Dec 27;16(6):4401-4406. Epub 2018 Sep 27.

Department of Neurology, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252601, P.R. China.

The aim of the study was to investigate and discuss the activation of astrocytes and the expression of inflammatory cytokines in rats with experimental autoimmune encephalomyelitis (EAE). Twenty Wistar rats were randomly divided into the normal control (n=10) and EAE group (n=10). The rats in the EAE group were injected intraperitoneally with myelin oligodendrocyte glycoprotein 35-55 emulsion, and those in the control group were injected with the equivalent volume of normal saline. Read More

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December 2018

Exenatide reduces oxidative stress and cell death in testis in iron overload rat model.

Exp Ther Med 2018 Dec 26;16(6):4349-4356. Epub 2018 Sep 26.

Department of Anesthesiology and Reanimation, Gazi University Medical Faculty, Ankara 06510, Turkey.

Glucagon-like peptide-1 (GLP-1) has been demonstrated to affect the oxidative stress status in several and clinical studies. The aim of the present study was to evaluate the effect of a GLP-1 analogue, exenatide, on oxidative stress parameters and apoptotic markers in testicular cells in an iron overload rat model. To obtain this model, the animals were randomly divided into three groups (n=6/group). Read More

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December 2018

Comparative evaluation of dexmedetomidine and labetalol for attenuating hemodynamic stress responses during laparoscopic cholecystectomy in borderline hypertensive patients.

Rev Esp Anestesiol Reanim 2018 Dec 10. Epub 2018 Dec 10.

Department of Obstetrics and Gynecology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Objective: Various pharmacological agents have been tried to attenuate the pressor response in laparoscopic cholecystectomy patients. We have compared single pre-induction intravenous injection of dexmedetomidine with labetalol for attenuation of haemodynamic stress response.

Methods: A total of 160 patients were considered for this prospective, randomized, double blind clinical study done in a single tertiary care institution. Read More

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December 2018

In vitro removal of anti-infective agents by a novel cytokine adsorbent system.

Int J Artif Organs 2018 Dec 13:391398818812601. Epub 2018 Dec 13.

1 Department of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Objectives:: The aim of this study is to describe the in vitro adsorption of anti-infective drugs onto an extracorporeal cytokine adsorber.

Methods:: Various anti-infective drugs (β-lactams, quinolones, aminoglycosides, glycopeptides, azole antimycotics) were prepared in normal saline 0.9% and human albumin 5%, and pumped through a cytokine cartridge (CytoSorb; CytoSorbents Corporation, Monmouth Junction, NJ, USA) at a flow rate of 1. Read More

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December 2018

Studies on Silver Ions Releasing Processes and Mechanical Properties of Surface-Modified Titanium Alloy Implants.

Int J Mol Sci 2018 Dec 9;19(12). Epub 2018 Dec 9.

Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.

Dispersed silver nanoparticles (AgNPs) on the surface of titanium alloy (Ti6Al4V) and titanium alloy modified by titania nanotube layer (Ti6Al4V/TNT) substrates were produced by the chemical vapor deposition method (CVD) using a novel precursor of the formula [Ag₅(O₂CC₂F₅)₅(H₂O)₃]. The structure and volatile properties of this compound were determined using single crystal X-ray diffractometry, variable temperature IR spectrophotometry (VT IR), and electron inducted mass spectrometry (EI MS). The morphology and the structure of the produced Ti6Al4V/AgNPs and Ti6Al4V/TNT/AgNPs composites were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). Read More

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December 2018

Royal Jelly Abrogates Cadmium-Induced Oxidative Challenge in Mouse Testes: Involvement of the Nrf2 Pathway.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt.

The current study examined the efficacy of royal jelly (RJ) against cadmium chloride (CdCl₂)-induced testicular dysfunction. A total of 28 Swiss male mice were allocated into four groups (n = 7), and are listed as follows: (1) the control group, who was intraperitoneally injected with physiological saline (0.9% NaCl) for 7 days; (2) the RJ group, who was orally supplemented with RJ (85 mg/kg daily equivalent to 250 mg crude RJ) for 7 days; (3) the CdCl₂ group, who was intraperitoneally injected with 6. Read More

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December 2018

Targeting IL-13Rα2 for effective treatment of malignant peripheral nerve sheath tumors in mouse models.

Authors:

J Neurosurg 2018 Nov 1:1-11. Epub 2018 Nov 1.

OBJECTIVEMalignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas that harbor a high potential for metastasis and have a devastating prognosis. Combination chemoradiation aids in tumor control and decreases tumor recurrence but causes deleterious side effects and does not extend long-term survival. An effective treatment with limited toxicity and enhanced efficacy is critical for patients suffering from MPNSTs. Read More

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November 2018

Eimeria challenge adversely affected long bone attributes linked to increased resorption in 14-day-old broiler chickens.

Poult Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.

There is limited information on the effects of enteric pathogen on bone quality in rapidly growing broiler chicks. We examined tibia and femur attributes (length, diameter, relative weight of ash content [AC] to the BW, ash concentration [AP]) and serum bone-turnover markers including receptor activator of nuclear factor kappa-B ligand (RANKL) for resorption, alkaline phosphatase (ALP) for mineralization, and selected serum metabolites in 14-day-old broilers challenged with Eimeria. A total of 160 (80 males and 80 females) 1-day-old Ross × Ross 708 chicks were used. Read More

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December 2018

Antigen-specific CD4 and CD8 T-cell responses in PBMC from pony mares immunized with either native or recombinant zona pellucida vaccines.

Theriogenology 2018 Dec 5;126:106-113. Epub 2018 Dec 5.

Veterinary Population Management Laboratory, Faculty of Veterinary Science, University of Pretoria, Old Soutpan Road, Onderstepoort, 0110, South Africa.

Few studies have investigated the cell mediated immune response during zona pellucida-based immunocontraception, despite hypothesized cytotoxic T-cell involvement in ovarian dysfunction associated with these vaccines. This study aimed to investigate antigen-specific anamnestic responses of helper (CD4) and cytotoxic (CD8) T-lymphocytes in peripheral blood mononuclear cells (PBMC) isolated from pony mares before and after their treatment with native porcine zona pellucida (pZP), recombinant pZP3 and pZP4 antigens (reZP) or adjuvanted saline. Mares were randomly assigned to pZP, reZP and control groups (n = 7 per group). Read More

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December 2018
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A Microbiota-Derived Bacteriocin Targets the Host to Confer Diarrhea Resistance in Early-Weaned Piglets.

Cell Host Microbe 2018 Dec;24(6):817-832.e8

State Key Laboratory of Agricultural Microbiology, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei 430070, China; Hubei Provincial Engineering Laboratory for Pig Precision Feeding and Feed Safety Technology, Wuhan, Hubei 430070, China. Electronic address:

Alternatives to antibiotics for preventing diarrhea in early-weaned farm animals are sorely needed. CM piglets (a native Chinese breed) are more resistant to early-weaning stress-induced diarrhea than the commercial crossbred LY piglets. Transferring fecal microbiota, but not saline, from healthy CM into LY piglets by oral administration prior to early weaning conferred diarrhea resistance. Read More

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December 2018

Absence of Healing Impairment in Osteotomies Prepared via Osseodensification Drilling.

Int J Periodontics Restorative Dent 2019 Jan/Feb;39(1):65-71

This study sought to qualitatively and quantitatively evaluate the effect of osteotomy preparation by conventional (control group) or OD (OD group) instrumentation on osteotomy healing. An incision of 10 cm was made in the anteroposterior direction over the hip in five sheep, and 15 osteotomies were prepared in the left ilium of the sheep (n = 3/sheep). Three different instrumentation techniques were utilized: (1) conventional/regular drilling (R [recommended by manufacturer]) in a 3-step series of a 2-mm pilot, 3. Read More

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December 2018

Phytoactinopolyspora halophila sp. nov., a halophilic actinomycete isolated from a saline soil.

Int J Syst Evol Microbiol 2018 Dec 13. Epub 2018 Dec 13.

1​Key Laboratory for Conservation and Utilization of Bio-resource, and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, PR China.

A novel halophilic actinobacterial strain, designated YIM 96934, was isolated from a soil sample collected from the edge of a saline lake in Xinjiang, north-west China. The taxonomic position of the strain was investigated using a polyphasic approach. Cells of the strain were aerobic and Gram-stain-positive. Read More

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December 2018

Passenger head kinematics in abrupt braking and lane change events.

Traffic Inj Prev 2018 Dec 13:1-8. Epub 2018 Dec 13.

b Toyota Motor North America , Saline , Michigan.

Objective: A test track study was conducted to quantify patterns of adult front seat passenger head motion during abrupt vehicle maneuvers.

Method: Eighty-seven men and women with a wide range of body sizes and ages participated in data collection on a closed test track in a passenger sedan under manual control by a test driver. Because a primary goal of the study was to gather "unaware" data, the participants were instructed that the study was concerned with vehicle dynamics and they were required to read from a questionnaire taped to the top of their thighs as the drive began. Read More

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December 2018

Effects of hypertonic dextrose injection on chronic supraspinatus tendinopathy of the shoulder: randomized placebo-controlled trial.

Eur J Phys Rehabil Med 2018 Dec 13. Epub 2018 Dec 13.

Graduate Institute of Sports Science, National Taiwan Sports University, Taoyuan, Taiwan -

Background: Rotator cuff lesions are common causes of shoulder pain. Although patients with symptoms caused by chronic rotator cuff tendinopathy can be treated using conservative treatments, some of them may still experience refractory symptoms. Hypertonic dextrose prolotherapy (DPT) may be another treatment choice for these refractory symptoms. Read More

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December 2018
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Vascular responses of aortic, renal, and uterine arteries in suramin-induced preeclampsia-like syndrome in rats

Turk J Med Sci 2018 12 12;48(6):1328-1339. Epub 2018 Dec 12.

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. We aimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic, renal, and uterine arteries.

Materials And Methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of saline on days 10 and 11. Read More

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December 2018

Roles of ERK1/2 and PI3K/AKT signaling pathways in mitochondria-mediated apoptosis in testes of hypothyroid rats.

Toxicol Res (Camb) 2018 Nov 27;7(6):1214-1224. Epub 2018 Aug 27.

Department of Toxicology , School of Public Health , Lanzhou University , Lanzhou , 730000 , China . Email: ; Tel: +86-931-8915010.

The absence of the thyroid hormone (TH) could impair testicular function, but its mechanism is still rudimentary. This study aims to explore the roles of estrogen receptor (ER α, β) and G protein-coupled receptor 30 (GPR30), extracellular signal regulated kinase (ERK1/2) and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathways in apoptosis in testes of hypothyroidism rats. Male Wistar rats were randomly divided into control (C), low-(L) and high-hypothyroidism (H) groups [1 mL per 100 g BW per day normal saline, 0. Read More

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November 2018

The role of PI3-K/Akt signal pathway in the antagonist effect of CEPO on CHF rats.

Exp Ther Med 2018 Dec 2;16(6):5161-5165. Epub 2018 Oct 2.

Department of Cardiovascular Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.

The possible role of phosphoinositide 3-kinase (PI3-K)/protein kinase B (Akt) signal pathway in the antagonist effect of carbamylated erythropoietin (CEPO) on chronic heart failure (CHF) in rats was investigated. Twenty of 120 rats were randomly selected as the control group, and the remaining rats as the model group. Rats in the model group received intraperitoneal injection of isoproterenol, those in the control group underwent intraperitoneal injection of equivalent normal saline. Read More

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December 2018

Anti-inflammatory effects of bone marrow mesenchymal stem cells on mice with Alzheimer's disease.

Exp Ther Med 2018 Dec 12;16(6):5015-5020. Epub 2018 Oct 12.

Department of Neurology Medicine, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.

Anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs) on mice with Alzheimer's disease (AD) were investigated. Twenty amyloid precursor protein (APP)/presenilin-1 (PS1) double transgenic mice were randomly divided into two groups: the AD control group and the stem cell treatment group. The normal control group consisted of 10 non-transgenic mice. Read More

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December 2018

Hypothermic treatment after computer-controlled compression in minipig: A preliminary report on the effect of epidural vs. direct spinal cord cooling.

Exp Ther Med 2018 Dec 5;16(6):4927-4942. Epub 2018 Oct 5.

Institute of Neurobiology, Biomedical Research Center, Slovak Academy of Sciences, 040 01 Košice, Slovakia.

The aim of the present study was to investigate the therapeutic efficacy of local hypothermia (beginning 30 min post-injury persisting for 5 h) on tissue preservation along the rostro-caudal axis of the spinal cord (3 cm cranially and caudally from the lesion site), and the prevention of injury-induced functional loss in a newly developed computer-controlled compression model in minipig (force of impact 18N at L3 level), which mimics severe spinal cord injury (SCI). Minipigs underwent SCI with two post-injury modifications (durotomy vs. intact dura mater) followed by hypothermia through a perfusion chamber with cold (epidural t≈15°C) saline, DMEM/F12 or enriched DMEM/F12 (SCI/durotomy group) and with room temperature (t≈24°C) saline (SCI-only group). Read More

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December 2018
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Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting.

Exp Ther Med 2018 Dec 19;16(6):4685-4689. Epub 2018 Sep 19.

Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, P.R. China.

Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting were investigated. Eighty patients undergoing systemic anesthesia with extracorporeal coronary artery bypass grafting in The People's Hospital of Guangxi Zhuang Autonomous Region from January 2015 to August 2017 were selected and randomly divided into the observation group (n=40) and control group (n=40). The two groups were treated with dexmedetomidine and equal volume of normal saline, respectively. Read More

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December 2018

miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2.

Biosci Rep 2018 Dec 12. Epub 2018 Dec 12.

The first afflicted hospital of Xi'an JiaoTong University, Xi'an, China.

This study aimed to explore miR-125 effects on RA development to provide a potential target for RA. Briefly, rat RA model was established (Model group) by injection of Freund's Complete Adjuvant into the left hind toe. Normal rats injected with saline in the same location were set as Normal group. Read More

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December 2018

Auditory and Histopathological Effects of Topical Mercurochrome Treatment in Rats with Tympanic Membrane Perforation.

J Int Adv Otol 2018 Dec 12. Epub 2018 Dec 12.

Department of Otorhinolaryngology, Health Sciences University, İzmir Bozyaka Training and Research Hospital, İzmir, Turkey.

Objectives: Topical treatment is first choice in the treatment of uncomplicated chronic otitis media. It was intended to assess auditory and histopathological safety of ototopical use of mercurochrome solution in rats with induced tympanic membrane perforation.

Materials And Methods: The study was conducted on 21 female Wistar-Albino rats which were randomly assigned into 3 groups. Read More

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December 2018

[Epinephrine combined with acupuncture therapy can treat anaphylactic shock mice through nuclear factor-κB signaling pathway: a rat experimental result].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1083-1086

Department of Dermatology, Xinxiang Central Hospital, Xinxiang 453000, Henan, China. Corresponding author: Gan Caibin, Email:

Objective: To explore the therapeutic effect of epinephrine combined with acupuncture on anaphylactic shock and its mechanism.

Methods: Sixty male Kunming mice were randomly divided into normal saline (NS) group, anaphylactic shock model group, and integrated traditional Chinese and Western medicine treatment group with 20 mice in each group. The anaphylactic shock model was reproduced by egg albumin infusion: intraperitoneal injection of 0. Read More

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November 2018

[Regulatory effect of hemichannels protein Pannexin-1 on P2X7 receptor activity in the lungs of mice with lung injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1071-1076

Department of Critical Care Medicine, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, Liaoning, China. Corresponding author: Zang Bin, Email:

Objective: To investigate the regulative effect of hemichannels protein Pannexin-1 on P2X7 receptor activation and caspase-1 mediated inflammatory response in the lungs of mice with lung injury.

Methods: Sixty male C57BL/6 mice were randomly divided into five groups with 12 mice in each group: sham operation group (Sham group), mechanical ventilation (MV) group, MV + low dose lipopolysaccharide (LPS) group (MLL group), MV + medium and high dose LPS group (MML group) and MV + high dose LPS group (MHL group). A "two-hit" lung injury model was reproduced by MV with high tidal volume combined with LPS injection in airway. Read More

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November 2018

[Effects of keratinocyte growth factor-2 on expressions of chemokine FKN and tight junction protein claudin-5 in lung of rats with acute lung injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1066-1070

Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China (Shao TH); Department of Intensive Care Unit, Ningxia Medical University General Hospital, Yinchuan 750004, Ningxia Hui Autonomous Region, China (Bai JJ, Ma XG). Corresponding author: Ma Xigang, Email:

Objective: To observe the effects of keratinocyte growth factor-2 (KGF-2) on the expressions of chemokine FKN and tight junction protein claudin-5 in lung tissue of rats with acute lung injury (ALI).

Methods: Healthy male Sprague-Dawley (SD) rats were randomly divided into normal saline (NS) control group, ALI model group and KGF-2 pretreatment group, with 10 rats in each group. The rat ALI model was reproduced by injection of 0. Read More

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November 2018

Cartilage repair and inhibition of the progression of cartilage degeneration after transplantation of allogeneic chondrocyte sheets in a nontraumatic early arthritis model.

Regen Ther 2018 Dec 24;9:24-31. Epub 2018 Aug 24.

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Introduction: Using a rat model of nontraumatic early arthritis induced by intra-articular administration of low-dose monoiodoacetic acid (MIA), we transplanted allogeneic chondrocyte sheets and examined the effects on tissue repair.

Methods: MIA (0.2 mg/50 μl) was injected into the right knee of 20 male Wistar rats. Read More

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December 2018

Multilineage-differentiating stress-enduring (Muse)-like cells exist in synovial tissue.

Regen Ther 2019 Jun 20;10:17-26. Epub 2018 Nov 20.

Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Introduction: Cartilage regeneration is a promising therapy for restoring joint function in patients with cartilage defects. The limited availability of autologous chondrocytes or chondrogenic progenitor cells is an obstacle to its clinical application. We investigated the existence and chondrogenic potential of synovial membrane-derived multilineage-differentiating stress-enduring (Muse)-like cells as an alternative cell source for cartilage regeneration. Read More

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Diamond/Porous Titanium Nitride Electrodes With Superior Electrochemical Performance for Neural Interfacing.

Front Bioeng Biotechnol 2018 15;6:171. Epub 2018 Nov 15.

Laboratory for Stem Cell Research, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Robust devices for chronic neural stimulation demand electrode materials which exhibit high charge injection () capacity and long-term stability. Boron-doped diamond (BDD) electrodes have shown promise for neural stimulation applications, but their practical applications remain limited due to the poor charge transfer capability of diamond. In this work, we present an attractive approach to produce BDD electrodes with exceptionally high surface area using porous titanium nitride (TiN) as interlayer template. Read More

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November 2018

Immunogenicity evaluation of plasmids encoding Omp25 and Omp31 antigens in BALB/c mice.

Iran J Basic Med Sci 2018 Sep;21(9):957-964

Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.

Objectives: Vaccination is one of the most effective means to protect humans and animals against brucellosis. Live attenuated Brucella vaccines are considered effective in animals but they may be potentially infectious to humans, so it is vital to improve the immunoprotective effects and safety of vaccines against Brucella. This study was designed to evaluate the immunogenicity of DNA vaccines encoding outer membrane proteins (Omp25 and Omp31) against Rev1 in a mouse model. Read More

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September 2018

Evaluation of antibiotic activity of methicillin in healing of full-thickness infected wounds with sensitized methicillin resistant in the presence of HAMLET.

Iran J Basic Med Sci 2018 Oct;21(10):1043-1049

Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Objectives: The novel healing choices for handling of infections due to multidrug resistant are reguired. HAMLET has been reported to be able to sensitize bacterial pathogens to traditional antimicrobial agents. The aim was to assess wound healing activity of methicillin in presence of HAMLET in methicillin resistant (MRSA) infected wounds. Read More

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October 2018

Sulfur dioxide reduces hippocampal cell death and improves learning and memory deficits in a rat model of transient global ischemia/reperfusion.

Iran J Basic Med Sci 2018 Oct;21(10):998-1003

Addiction Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.

Objectives: According to recent the findings, sulfur dioxide (SO) is produced by the cardiovascular system, influencing some major biological processes. Based on previous research, SO exhibits antioxidant effects and inhibits apoptosis following cardiac ischemia/reperfusion. Therefore, the objective of the current study was to examine the neuroprotective impact of SO2 following global cerebral ischemia/reperfusion (I/R). Read More

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October 2018

5-Aminolevulinic Acid-Based Photodynamic Therapy Pretreatment Mitigates Ultraviolet A-Induced Oxidative Photodamage.

Oxid Med Cell Longev 2018 7;2018:9420745. Epub 2018 Nov 7.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Aim: To determine whether 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) is effective in combating ultraviolet A- (UVA-) induced oxidative photodamage of hairless mice skin and human epidermal keratinocytes .

Methods: In experiments, the human keratinocyte cell line (HaCaT cells) was divided into two groups: the experimental group was treated with ALA-PDT and the control group was left untreated. Then, the experimental group and the control group of cells were exposed to 10 J/m of UVA radiation. Read More

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November 2018

Intake of a fermented plant product attenuates allergic symptoms without changing systemic immune responses in a mouse model of Japanese cedar pollinosis.

World Allergy Organ J 2018 4;11(1):31. Epub 2018 Dec 4.

1Hiroshima Research Center for Healthy Aging (HiHA), Graduate School of Advanced Sciences of Matter, Hiroshima University, 1-3-1 Kagamiyama Higashi-Hiroshima, Hiroshima, 739-8530 Japan.

Background: Japanese cedar pollinosis (JCP) is one of the most prevalent allergies in Japan. Within the past few decades, many food factors have been demonstrated to suppress symptoms of pollinosis and mast cell degranulation directly or indirectly. Herein, we conducted a study to clarify the anti-allergic potency of a fermented plant product (FPP) in JCP model mice. Read More

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December 2018

Nephroprotective Effects of Benzyl Isothiocyanate and Resveratrol Against Cisplatin-Induced Oxidative Stress and Inflammation.

Front Pharmacol 2018 21;9:1268. Epub 2018 Nov 21.

Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.

This study was performed to compare the nephroprotective effects of benzyl isothiocyanate (BITC) and resveratrol (RES) and investigate the nephroprotective efficacy of their combination against cisplatin-induced acute renal injury. Five animal groups (each of eight) received either normal saline, a single intraperitoneal injection of cisplatin (20 mg/kg) at the sixth day, cisplatin plus oral RES (30 mg/kg) or BITC (100 mg/kg in diet), or a combination of both for 10 days. Compared to saline-treated mice, cisplatin-intoxicated mice had significantly higher ( < 0. Read More

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November 2018

Striatal Protection in nNOS Knock-Out Mice After Quinolinic Acid-Induced Oxidative Damage.

Neurochem Res 2018 Dec 6. Epub 2018 Dec 6.

Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Insurgentes Sur #3877, Col. La Fama Del. Tlalpan, 14269, Ciudad de México, Mexico.

Under pathological conditions, nitric oxide can become a mediator of oxidative cellular damage, generating an unbalance between oxidant and antioxidant systems. The participation of neuronal nitric oxide synthase (nNOS) in the neurodegeneration mechanism has been reported; the activation of N-methyl-D-aspartate (NMDA) receptors by agonist quinolinic acid (QUIN) triggers an increase in nNOS function and promotes oxidative stress. The aim of the present work was to elucidate the participation of nNOS in QUIN-induced oxidative stress in knock-out mice (nNOS-/-). Read More

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December 2018

Effect of age, sex, and season on the prevalence of Linguatula serrata infestation in mesenteric lymph nodes of goats slaughtered in Tabriz, Iran.

Trop Anim Health Prod 2018 Dec 6. Epub 2018 Dec 6.

Young Researchers and Elite Club, Zabol Branch, Islamic Azad University, Zabol, Iran.

This research was conducted to determine the prevalence and intensity of infection with nymphs of Linguatula serrata in mesenteric lymph nodes of the goats from northwest of Iran. Moreover, the intensity of infection of mesenteric lymph nodes was compared based on gross appearance and the morphological changes in these nodes. In addition, the effects of age, sex, and season on the prevalence of Linguatula serrata were assessed. Read More

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December 2018

Selenium Attenuates Staphylococcus aureus Mastitis in Mice by Inhibiting the Activation of the NALP3 Inflammasome and NF-κB/MAPK Pathway.

Biol Trace Elem Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China.

Mastitis is one of the most important diseases affecting the dairy industry in the world, and it also poses a great threat to human food safety. In this study, we explored whether selenium can inhibit the activation of the NALP3 inflammasome and NF-κB/MAPK pathway to achieve anti-inflammatory effects. Sixty BALB/c female mice were randomly divided into three groups according to diets of different selenium concentrations (high, normal, and low). Read More

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December 2018

De-airing an open stent graft to potentially reduce spinal cord injury.

Gen Thorac Cardiovasc Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 236-0004, Japan.

We have occasionally observed a bubble leaving the suture line of an open stent graft; hence, we hypothesized that de-airing an open stent graft could potentially reduce spinal cord injury. Postoperative computed tomography often showed residual air in thoracic aortic aneurysms, confirmed by the presence of a certain amount of air in an open stent graft in a dry lab. We filled CO in the sterilized package of an open stent graft and subsequently filled it with saline, which absorbed the CO and entered into the gap of the graft. Read More

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December 2018

Ethanol acutely antagonizes the refeeding-induced increase in mTOR-dependent protein synthesis and decrease in autophagy in skeletal muscle.

Mol Cell Biochem 2018 Dec 6. Epub 2018 Dec 6.

Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, 17033, USA.

The purpose of this study was to determine the impact of acute ethanol administration on the major signal transduction pathways in skeletal muscle responsible for regulating the protein synthetic and degradative response to refeeding. Adult male C57Bl/6 mice were fasted overnight; mice were then either refed normal rodent chow for 30 min or a separate group of mice remained food deprived (i.e. Read More

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December 2018

Preparation, optimization and swelling study of carboxymethyl sago starch (CMSS)-acid hydrogel.

Chem Cent J 2018 Dec 6;12(1):133. Epub 2018 Dec 6.

Laboratory of Vaccine and Immunotherapeutic, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

In this study, sago starch was modified in order to enhance its physicochemical properties. Carboxymethylation was used to introduce a carboxymethyl group into a starch compound. The carboxymethyl sago starch (CMSS) was used to prepare smart hydrogel by adding acetic acid into the CMSS powder as the crosslinking agent. Read More

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December 2018

Synthesis, characterization, molecular docking, analgesic, antiplatelet and anticoagulant effects of dibenzylidene ketone derivatives.

Chem Cent J 2018 Dec 6;12(1):134. Epub 2018 Dec 6.

Basic Sciences Department, College of Science and Health Professions-(COSHP-J), King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

In this study dibenzylidene ketone derivatives (2E,5E)-2-(4-methoxybenzylidene)-5-(4-nitrobenzylidene) cyclopentanone (AK-1a) and (1E,4E)-4-(4-nitrobenzylidene)-1-(4-nitrophenyl) oct-1-en-3-one (AK-2a) were newly synthesized, inspired from curcuminoids natural origin. Novel scheme was used for synthesis of AK-1a and AK-2a. The synthesized compounds were characterized by spectroscopic techniques. Read More

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December 2018

[Influence of nourishing yin and tonifying yang sequential therapy combined with Western medicine on TGF-β1/Smads signaling pathway in anovulatory infertility rats with diminished ovarian reserve].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1068-1074

First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210029, China.

Objective: To explore the influence for combination of nourishing yin and tonifying yang sequential therapy (NYTYST) with Western medicine in treating anovulatory infertility rats with diminished ovarian reserve (DOR) based on TGF-β1/Smads signaling pathway. 
 Methods: A total of 40 female rats were randomly divided into 5 groups, a normal control group, a model group, a Western medicine group, a NYTYST group and a combination group (n=8 in each group). The DOR model was established through orally taking tripterygium pill for continuous 2 weeks. Read More

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October 2018

A comparative study of the pharmacokinetics of clozapine N-oxide and clozapine N-oxide hydrochloride salt in rhesus macaques.

J Pharmacol Exp Ther 2018 Dec 6. Epub 2018 Dec 6.

Oregon Health & Science University;

Translating chemogenetic techniques from non-human primates to potential clinical applications has been complicated in part due to in vivo conversion of the chemogenetic actuator, clozapine N-oxide (CNO), to its pharmacologically active parent compound, clozapine, a ligand with known side-effects, including five FDA boxed warnings. Additionally, the limited solubility of CNO requires high concentrations of potentially toxic detergents such as dimethyl sulfoxide (DMSO). To address these concerns, pharmacokinetic profiling of commercially available CNO in DMSO (CNO-DMSO, 10% v/v DMSO in saline) and a water-soluble salt preparation (CNO-HCl, saline) was conducted in rhesus macaques. Read More

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December 2018

Safety and efficacy of allogenic placental mesenchymal stem cells for treating knee osteoarthritis: a pilot study.

Cytotherapy 2018 Dec 3. Epub 2018 Dec 3.

Cell-based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Pathology and Cell-based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: Knee osteoarthritis (OA) is a common skeletal impairment that can cause many limitations in normal life activities. Stem cell therapy has been studied for decades for its regenerative potency in various diseases. We investigated the safety and efficacy of intra-articular injection of placental mesenchymal stem cells (MSCs) in knee OA healing. Read More

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December 2018

Immune system stimulation increases dietary threonine requirements for protein deposition in growing pigs.

J Anim Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Animal and Food Sciences, Texas Tech University, Lubbock, Texas.

Previous studies have reported an increase in the utilization of threonine (Thr) during immune system stimulation (ISS). However, increased utilization of an amino acid (AA) during ISS may not reflect an increased dietary requirement, as endogenous sources may supply AA to meet the need for enhanced utilization. The current study evaluated the impact of ISS on components of dietary Thr requirements, i. Read More

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December 2018

Intra-articular Steroids vs Saline for Lumbar Z-Joint Pain: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial.

Pain Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Physical Medicine and Rehabilitation, Vanderbilt University, Nashville, Tennessee.

Objective: To determine if intra-articular (IA) injection of corticosteroids is effective in reducing the need for radiofrequency ablation (RFA) in those with dual comparative medial branch block (MBB)-confirmed lumbar z-joint pain.

Design: This was a randomized, double blind, placebo-controlled study.

Setting: Two academic medical centers. Read More

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December 2018
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