39,956 results match your criteria Sacral Plexus


Effects of Olfactory Mucosa Stem/Stromal Cell and Olfactory Ensheating Cells Secretome on Peripheral Nerve Regeneration.

Biomolecules 2022 Jun 11;12(6). Epub 2022 Jun 11.

Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua D. Manuel II, Apartado 55142, 4051-401 Porto, Portugal.

Cell secretome has been explored as a cell-free technique with high scientific and medical interest for Regenerative Medicine. In this work, the secretome produced and collected from Olfactory Mucosa Mesenchymal Stem Cells and Olfactory Ensheating Cells was analyzed and therapeutically applied to promote peripheral nerve regeneration. The analysis of the conditioned medium revealed the production and secretion of several factors with immunomodulatory functions, capable of intervening beneficially in the phases of nerve regeneration. Read More

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Kilohertz alternating current neuromodulation of the pudendal nerves: effects on the anal canal and anal sphincter in rats.

J Appl Biomed 2022 Jun 21;20(2):56-69. Epub 2022 Jun 21.

Erasmus Medical Center, Department of Urology, Rotterdam, Zuid-Holland, Netherlands.

The first two objectives were to establish which stimulation parameters of kilohertz frequency alternating current (KHFAC) neuromodulation influence the effectiveness of pudendal nerve block and its safety. The third aim was to determine whether KHFAC neuromodulation of the pudendal nerve can relax the pelvic musculature, including the anal sphincter. Simulation experiments were conducted to establish which parameters can be adjusted to improve the effectiveness and safety of the nerve block. Read More

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Immortalized Bone Mesenchymal Stromal Cells With Inducible Galanin Expression Produce Controllable Pain Relief in Neuropathic Rats.

Cell Transplant 2022 Jan-Dec;31:9636897221103861

Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Management of chronic pain is one of the most difficult problems in modern practice. Grafted human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) with inducible galanin (GAL) expression have been considered to be a potentially safe and controllable approach for the alleviation of chronic pain. Therefore, in this study, we aimed to assess the feasibility of hTERT-BMSCs/Tet-on/GAL cells secreting GAL under the transcriptional control of doxycycline (Dox) for controllable pain relief. Read More

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Implantation of a nerve protector embedded with human GMSC-derived Schwann-like cells accelerates regeneration of crush-injured rat sciatic nerves.

Stem Cell Res Ther 2022 Jun 20;13(1):263. Epub 2022 Jun 20.

Department of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA, 19104, USA.

Background: Peripheral nerve injuries (PNIs) remain one of the great clinical challenges because of their considerable long-term disability potential. Postnatal neural crest-derived multipotent stem cells, including gingiva-derived mesenchymal stem cells (GMSCs), represent a promising source of seed cells for tissue engineering and regenerative therapy of various disorders, including PNIs. Here, we generated GMSC-repopulated nerve protectors and evaluated their therapeutic effects in a crush injury model of rat sciatic nerves. Read More

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Frozen vein wrapping for chronic nerve constriction injury reduces sciatic nerve allodynia in a rat model.

BMC Neurosci 2022 Jun 20;23(1):37. Epub 2022 Jun 20.

Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan.

Background: Autologous vein wrapping (VW) is used in the treatment of recurrent chronic constriction neuropathy and traumatic peripheral nerve injury. However, use of autologous veins is limited by the inability to obtain longer veins of sufficient length for larger sites. Frozen allograft tissue has several advantages, including its availability for large grafts, avoidance of donor-site morbidity, and shorter operation time. Read More

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Ischiofemoral impingement syndrome provoked by labor: An unusual case of complete sciatic mononeuropathy.

Neuroradiol J 2022 Jun 18:19714009221109895. Epub 2022 Jun 18.

Department of Neurology, 6915Mayo Clinic, Rochester, MN, USA.

Peripheral neuropathies are a recognized complication of labor in the post-partum period. Herein, we describe an uncommon presentation of sciatic mononeuropathy due to ischiofemoral impingement during labor. A 29-year-old, gravida 4 para 2, female presented post-partum with acute left lower limb paresthesia and left foot drop, following spontaneous vaginal delivery of twins. Read More

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Imaging peripheral nerve micro-anatomy with MUSE, 2D and 3D approaches.

Sci Rep 2022 Jun 17;12(1):10205. Epub 2022 Jun 17.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.

Understanding peripheral nerve micro-anatomy can assist in the development of safe and effective neuromodulation devices. However, current approaches for imaging nerve morphology at the fiber level are either cumbersome, require substantial instrumentation, have a limited volume of view, or are limited in resolution/contrast. We present alternative methods based on MUSE (Microscopy with Ultraviolet Surface Excitation) imaging to investigate peripheral nerve morphology, both in 2D and 3D. Read More

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Sciatic nerve stimulation alleviates acute neuropathic pain via modulation of neuroinflammation and descending pain inhibition in a rodent model.

J Neuroinflammation 2022 Jun 15;19(1):153. Epub 2022 Jun 15.

Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: Neuropathic pain (NP) is characterized by abnormal activation of pain conducting pathways and manifests as mechanical allodynia and thermal hypersensitivity. Peripheral nerve stimulation is used for treatment of medically refractory chronic NP and has been shown to reduce neuroinflammation. However, whether sciatic nerve stimulation (SNS) is of therapeutic benefit to NP remains unclear. Read More

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Stimulation of the tibial nerve-a randomised trial for urinary problems associated with Parkinson's-the STARTUP trial.

Age Ageing 2022 Jun;51(6)

Yunus Centre for Social Business and Health, Glasgow Caledonian University, Glasgow G4 0BA, UK.

Background: non-motor symptoms such as bladder dysfunction are common (80%) in people with Parkinson's increasing the risk for falls with a negative impact on health-related costs and quality of life.We undertook STARTUP to evaluate the clinical and cost-effectiveness of using an adhesive electrode to stimulate the transcutaneous tibial nerve stimulation (TTNS) to treat bladder dysfunction in people with Parkinson's disease (PD).Study design, materials and methods: STARTUP was a parallel two-arm, multi-centre, pragmatic, double-blind, randomised controlled trial. Read More

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MR Neurography of Lumbosacral Plexus: Incremental Value Over XR, CT, and MRI of L Spine With Improved Outcomes in Patients With Radiculopathy and Failed Back Surgery Syndrome.

J Magn Reson Imaging 2022 Jun 14. Epub 2022 Jun 14.

Department of Radiology at UT Southwestern Medical Center, Dallas, Texas, USA.

Background: Lower back pain is often evaluated using magnetic resonance imaging (MRI) and conventional imaging, which provide incomplete information about the etiology of pain and lead to less than optimal management.

Hypothesis: MR neurography (MRN) of the lumbosacral (LS) plexus renders a more accurate diagnosis, alters the management strategy, and clinical outcomes of radiculopathy or failed back surgery Syndrome (FBSS) patients when compared to the conventional imaging modalities.

Study Type: Retrospective, cross-sectional. Read More

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Anatomic Variation of the Sciatic Nerve: A Study on the Prevalence, and Bifurcation Loci in Relation to the Piriformis and Popliteal Fossa.

Acta Med Acad 2022 Apr;51(1):52-58

Niger Delta University, Department of Human Anatomy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.

Objective: To examine and identify sciatic nerve variations in relation to the piriformis muscle, its prevalence, pattern and the course of its bifurcation loci.

Materials And Methods: Twenty-eight formalin fixed male cadavers comprising 56 lower limbs were used for this study. Dissection of the gluteal region and posterior compartment of the thigh was conducted to expose the sciatic nerve. Read More

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Femoral 3-in-1 Nerve Block for Total Knee Replacement, an Analgesic Approach Not to Be Neglected. Single Center Experience and Literature Review.

Acta Med Acad 2022 Apr;51(1):14-20

Department of Orthopedic Surgery, University Hospital of Heraklion, Greece.

Objectives: Total Knee Replacement Surgery (TKR) is one of the most common elective orthopedic operations. Postoperative pain after total knee replacement, remains a challenge. In this retrospective observational study, we evaluated the effectiveness of 3-in-1 nerve block in patients after total knee arthroplasty compared to standard opioid treatment, and we state the reasons why this approach should still be considered. Read More

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CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury.

Cells 2022 05 30;11(11). Epub 2022 May 30.

Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.

Activating and inhibitory immune receptors play a critical role in regulating systemic and central nervous system (CNS) immune and inflammatory processes. The CD200R1 immunoreceptor induces a restraining signal modulating inflammation and phagocytosis in the CNS under different inflammatory conditions. However, it remains unknown whether CD200R1 has a role in modulating the inflammatory response after a peripheral nerve injury, an essential component of the successful regeneration. Read More

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Achilles: Failed Acute Repair.

Foot Ankle Clin 2022 Jun 11;27(2):415-430. Epub 2022 May 11.

Georgetown University School of Medicine, Washington, DC, USA.

Acute Achilles tendon ruptures are commonly managed with surgical repair. This particular surgery is prone to rerupture, wound complications, deep vein thrombosis, and sural nerve injuries. In this chapter the authors discuss complications, how to avoid them, and ultimately how to manage complications with your patients. Read More

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Effect of Low-Dose Dexmedetomidine Combined with Lumbosacral Plexus Block Guided by Ultrasound Imaging Based on Image Segmentation Algorithm in Fracture Surgery.

Comput Intell Neurosci 2022 30;2022:8063874. Epub 2022 May 30.

Department of Anesthesiology, Hebei Gucheng Hospital, Hengshui 253800, Hebei, China.

The aim of this study was to analyze the application of ultrasound-guided low-dose dexmedetomidine combined with lumbosacral plexus block based on artificial intelligence algorithm in the surgical treatment of proximal femoral fractures. 104 patients with proximal femoral fractures were divided into 52 cases in the experimental group (ultrasound-guided lumbosacral plexus block combined with dexmedetomidine based on local fitting image segmentation algorithm) and 52 cases in the routine group (endotracheal intubation and inhalation combined with general anesthesia). An image segmentation algorithm based on local fitting was constructed to enhance the ultrasound image. Read More

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Low Intensity Focused Ultrasound Increases Duration of Anti-Nociceptive Responses in Female Common Peroneal Nerve Injury Rats.

Neuromodulation 2022 Jun;25(4):504-510

Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, USA; Department of Neurosurgery, Albany Medical Center, Albany, NY, USA. Electronic address:

Objective: Chronic pain affects 7%-10% of Americans, occurs more frequently and severely in females, and available treatments have been shown to have less efficacy in female patients. Preclinical models addressing sex-specific treatment differences in the treatment of chronic pain have been limited. Here we examine the sex-specific effects of low intensity focused ultrasound (liFUS) in a modified sciatic nerve injury (SNI) model. Read More

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Anesthetic management of hip fracture in geriatric patient with respiratory and heart failure using pericapsular nerve group block: A case report.

Medicine (Baltimore) 2022 Jun 3;101(22):e29478. Epub 2022 Jun 3.

Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Introduction: Hip fracture with severe cardiopulmonary and cerebral dysfunction is a relatively common problem in the elderly population and poses a great challenge to anesthetic management. Pericapsular nerve group (PENG) block combined with nerve blocks of the hip region has recently attracted significant interest from anesthesiologists, and very few reports on its anesthetic management exist.

Patient Concerns: Patient suffered from the right femoral neck fracture, combined with respiratory failure, heart failure, moderate-to-severe pulmonary hypertension, cerebral infarction, atrial fibrillation, and cognitive dysfunction. Read More

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Upregulation of neuronal progranulin mediates the antinociceptive effect of trimetazidine in paclitaxel-induced peripheral neuropathy: Role of ERK1/2 signaling.

Toxicol Appl Pharmacol 2022 Aug 2;448:116096. Epub 2022 Jun 2.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address:

Neuronal progranulin (PGRN) overexpression is an endogenous adaptive pain defense following nerve injury. It allows the survival of injured neurons to block enhanced nociceptive responses. Trimetazidine (TMZ) is widely used by cardiac patients as an anti-anginal drug, reflecting its anti-ischemic property. Read More

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The clinical value of using magnetic resonance contrast-enhanced three-dimensional nerve view in the diagnosis and management of sacral fracture accompanied by sacral plexus injury.

Technol Health Care 2022 May 14. Epub 2022 May 14.

Department of Traumatic Orthopaedics, Tianjin Hospital, Tianjin, China.

Background: The treatment of sacral fractures accompanied by nerve injury is complex and often leads to an unsatisfactory prognosis and poor quality of life in patients.

Objective: The present study aimed to investigate the clinical value of using 3.0T magnetic resonance contrast-enhanced three-dimensional (MR CE-3D) nerve view magnetic resonance neurography (MRN) in the diagnosis and management of a sacral fracture accompanied by a sacral plexus injury. Read More

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Applicability and effectiveness of ultrasound combined with nerve stimulator-guided lumbosacral plexus block in the supine versus lateral position during surgeries for lower limb fracture-a prospective randomized controlled trial.

BMC Anesthesiol 2022 Jun 3;22(1):174. Epub 2022 Jun 3.

Department of Anesthesiology, Chaohu Hospital of Anhui Medical University, Chaohu, Anhui, China.

Background: Patients with lower limb fracture often have acute pain and discomfort from changes in position, and such pain affects early postoperative recovery. This study aimed to compare the applicability and effectiveness of ultrasound combined with nerve stimulator-guided lumbosacral plexus block (LSPB) in the supine versus lateral position during lower limb fracture surgery.

Methods: We included 126 patients who underwent elective internal fixation for lower limb fracture who were divided into the S group and the L group by the random number table method and underwent LSPB guided by ultrasound combined with a nerve stimulator in the supine and lateral positions, respectively. Read More

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Spatio-temporal feature extraction in sensory electroneurographic signals.

Philos Trans A Math Phys Eng Sci 2022 Jul 6;380(2228):20210268. Epub 2022 Jun 6.

Edinburgh Neuroprosthetics Laboratory, School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK.

The recording and analysis of peripheral neural signal can provide insight for various prosthetic and bioelectronics medicine applications. However, there are few studies that investigate how informative features can be extracted from population activity electroneurographic (ENG) signals. In this study, five feature extraction frameworks were implemented on sensory ENG datasets and their classification performance was compared. Read More

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Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo.

Proc Natl Acad Sci U S A 2022 Jun 2;119(23):e2117764119. Epub 2022 Jun 2.

Department of Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139.

SignificanceBioelectronic medicine relies on electrical stimulation for most applications in the peripheral nervous system. It faces persistent challenges in selectively activating bundled nerve fibers. Here, we investigated ion-concentration modulation with ion-selective membranes and whether this modality may enhance the functional selectivity of peripheral nerve stimulation. Read More

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Effectiveness of pericapsular nerve group block with ultrasonography in patients diagnosed with hip fracture in the emergency department.

Ulus Travma Acil Cerrahi Derg 2022 Jun;28(6):832-838

Parexel International Ltd. Chandigarh-India.

Background: Hip fractures (HF) are among the most common fractures present in the emergency department and are very painful. Pericapsular nerve group block (PENG) is a new regional anesthesia technique developed for analgesia in total hip arthroplas-ties. We aimed to determine the effectiveness of PENG block used to reduce pain in patients with HF in the emergency department. Read More

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Is Femoral Nerve Block Superior to Fascia Iliac Block in Hip Surgery? Meta-Analysis of Randomized Controlled Trials.

Biomed Res Int 2022 19;2022:4840501. Epub 2022 May 19.

Department of Anesthesiology, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin 300192, China.

Background: Femoral nerve block (FNB) and fascia iliac compartment block (FICB) are alternative methods of pain relief during hip surgery. Nevertheless, the effectiveness and safety of FNB compared with FICB are yet to be fully determined.

Methods: Electronic databases were systematically searched. Read More

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Effects of bee honey on promotion of peripheral nerve regeneration in an experimental model of nerve crush injury.

Pak J Pharm Sci 2022 Mar;35(2):457-464

Department of Anatomy, College of Medicine, Taif University, Taif, Saudi Arabia.

Peripheral nerve injuries are commonly encountered within clinical settings because of accidental trauma. This study aimed to examine the therapeutic effect of bee honey on peripheral nerve crush injury through a histological and physiological perspective. In this study, forty Wistar rats were divided into four groups. Read More

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Detection of parametrial invasion in women with uterine cervical cancer using diffusion tensor imaging at 1.5T MRI.

Diagn Interv Imaging 2022 May 28. Epub 2022 May 28.

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC, di Radiologia, Fondazione Policlinico Universitario A. Gemelli IRCSS, Largo A. Gemelli, 8, 00168 Rome, Italy; Istituto di Radiologia, Università Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, Italy.

Purpose: The purpose of this study was to prospectively evaluate the capability of diffusion tensor imaging (DTI) of the lumbosacral plexus to identify parametrial invasion by uterine cervical cancer.

Materials And Methods: Twenty-seven women with biopsy-proven cervical cancer were prospectively enrolled and underwent DTI at 1.5 TMRI. Read More

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Antinociceptive effect of ethanolic extract of Bauhinia brachycarpa Benth on neuropathic pain model induced by partial sciatic nerve ligation.

J Ethnopharmacol 2022 Sep 28;295:115412. Epub 2022 May 28.

Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Dali, People's Republic of China; College of Pharmacy, Dali University, Dali, People's Republic of China. Electronic address:

Ethnopharmacological Relevance: The plant Bauhinia brachycarpa Benth (BBB) has been traditionally used for treating muscle aches such as bone pain, and neuralgia for a long time, on account of its sedative and antinociceptive activities in Yunnan province of China. However, there was no experimental evidence to confirm its traditional medicinal use.

Aim Of The Study: The antinociceptive effect and possible mechanism of ethanolic extract of BBB on neuropathic pain was evaluated through a model of partial sciatic nerve ligation in mice. Read More

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September 2022

Improvement of sciatic nerve regeneration by multichannel nanofibrous membrane-embedded electro-conductive conduits functionalized with laminin.

J Mater Sci Mater Med 2022 May 31;33(6):50. Epub 2022 May 31.

Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Multichannel structures in the design of nerve conduits offer potential advantages for regeneration of damaged nerves. However, lack of biochemical cues and electrical stimulation could hamper satisfactory nerve regeneration. The aim of this study was to simultaneously evaluate the effects of topographical, biological, and electrical cues on sciatic nerve regeneration. Read More

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Evaluation methods of a rat sciatic nerve crush injury model.

J Integr Neurosci 2022 May;21(3):91

Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 200437 Shanghai, China.

Background: The rat sciatic nerve crush injury model is one of the most commonly used models to research peripheral nerve injury (PNI), however, the evaluation of the model preparation lacks exact standards. This study aimed to investigate accurately assessment methods for research concerning the rat sciatic nerve crush injury.

Methods: The sciatic nerve crush injury model of was performed using the FST toothless forceps. Read More

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