1,318,197 results match your criteria SCI Psychosocial Process[Journal]


The Neuroprotective Peptide PACAP1-38 Contributes to Horizontal Cell Development in Postnatal Rat Retina.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):770-778

Department of Experimental Zoology and Neurobiology, University of Pécs, Pécs, Hungary.

Purpose: PACAP1-38, a member of the secretin/glucagon superfamily, is expressed in the developing retina with documented neuroprotective effects. However, its function in retinal cell differentiation has yet to be elucidated. Our goals, therefore, were to identify PAC1 expressing cells morphologically, investigate the PACAP1-38 action functionally, and establish PACAP1-38 regulated events developmentally during the first postnatal week in rat retina. Read More

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http://dx.doi.org/10.1167/iovs.18-25719DOI Listing
February 2019

Model-based description of disintegration time and dissolution rate of nanoparticle-loaded orodispersible films.

Eur J Pharm Sci 2019 Feb 19. Epub 2019 Feb 19.

Institute for Particle Technology, Technische Universität Braunschweig, Germany; PVZ - Center of Pharmaceutical Engineering, Technische Universität Braunschweig, Germany.

The embedding of nanoparticles in orodispersible films (ODFs) is an innovative strategy to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (API). As the films are supposed to disintegrate within seconds when placed in the mouth, the disintegration time of the ODFs as well as the dissolution behavior of the API are of great interest. This study introduces a new possibility for a model-based description of these film properties to enable a prediction for the process layout for the manufacturing of the nanoparticle-loaded ODFs. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.02.029DOI Listing
February 2019

Cytoplasmic OH scavenger TA293 attenuates cellular senescence and fibrosis by activating macrophages through oxidized phospholipids/TLR4.

Life Sci 2019 Feb 19. Epub 2019 Feb 19.

Laboratory of Physiological Chemistry, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma 370-0033, Japan.

Aims: Elucidation of the biological roles of the mitochondrial and cytoplasmic hydroxyl radical (cyto OH) is hampered by the absence of site-specific OH scavengers. Earlier findings using cyto OH scavenger, TA293, indicated that cyto OH causes cellular senescence, and senescence-associated secretory phenotype (SASP) factors secreted from cells cause macrophage infiltration, inflammation, and apoptosis. However, we found that macrophage infiltration occurs before senescent cells appear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.038DOI Listing
February 2019

Baicalin exerts antidepressant effects through Akt/FOXG1 pathway promoting neuronal differentiation and survival.

Life Sci 2019 Feb 19. Epub 2019 Feb 19.

Qinba Traditional Chinese Medicine Resources Research and Development Center, AnKang University, AnKang 725000, PR China; Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 639, Longmian Road, Nanjing 211198, China. Electronic address:

Background And Aims: Impaired neurogenesis in hippocampus may contribute to a variety of neurological diseases, such as Alzheimer's disease and depression. Baicalin (BA), which is mainly isolated from the root Scutellaria baicalensis Georgi (traditional Chinese herb), which was reported to facilitate neurogenesis, but how to play the role and the underlying molecular mechanisms are still unknown.

Main Methods: In this study, we adopted the chronic unpredictable mild stress (CUMS)-induced mouse model of depression, and then explore antidepressant-like effects and possible molecular mechanisms. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.033DOI Listing
February 2019

Quality by Design Driven Process Development of Cell Culture in Bioreactor for the Production of Foot-and-Mouth Veterinary Vaccine.

J Pharm Sci 2019 Feb 19. Epub 2019 Feb 19.

National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; Jiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China. Electronic address:

Quality by design (QbD) principle has been established as a guideline to emphasize the understanding of the relationship of product quality with process control. Vaccine product have characteristics of security and high efficiency, but it also has features like complexity and rigorous regulatory for production. This case study describes an example of QbD driven process development for manufacturing a veterinary vaccine produced with baby hamster kidney-21 (BHK-21) cells. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.02.004DOI Listing
February 2019

Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration.

J Pharm Sci 2019 Feb 19. Epub 2019 Feb 19.

It is of great challenge to predict human brain penetration for substrates of multidrug resistance protein 1 (MDR1) and/or breast cancer resistance protein (BCRP), two major efflux transporters at blood-brain barrier. Thus, a PBPK model with the incorporation of in vitro MDR1 and BCRP transporter function data and transporter protein expression levels has been developed. As such, it is crucial to generate MDR1 and BCRP substrate data with a high fidelity. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.02.005DOI Listing
February 2019

Innovation in Chemistry, Manufacturing, and Controls - A Regulatory Perspective From Industry.

J Pharm Sci 2019 Feb 19. Epub 2019 Feb 19.

Regulatory Affairs CMC, Amgen Inc., Thousand Oaks, CA, USA.

This review describes the landscape of novel modalities such as cell and gene therapies, viruses, other novel biologics, oligomers, and emerging technologies, including modern analytics. We summarize the regulatory history and recent landmark developments in some major markets and examine specific chemistry, manufacturing, and controls (CMC) challenges, including suggestions for exploration of potential science-based approaches in support of regulatory strategy development from an industry perspective. Additionally, we evaluate the economic factors contributing to patient access to innovation and discuss the impact of regulation. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.02.007DOI Listing
February 2019

Exercising choice and control: A qualitative meta-synthesis of perspectives of people with a spinal cord injury.

Arch Phys Med Rehabil 2019 Feb 19. Epub 2019 Feb 19.

School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA.

Objective: To systematically search the literature and construct a meta-synthesis of how choice and control are perceived by people with spinal cord injury (SCI) DATA SOURCES: Medline, Academic Search Premier, CINAHL, Cochrane, EMBASE, HealthSource, ProQuest, PsychInfo, SAGE and SCOPUS were searched from 1980 until September 2018 including all languages. Reference lists of selected studies were also reviewed.

Study Selection: Eligible qualitative studies included perspectives about choice of control as reported by people with SCI. Read More

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http://dx.doi.org/10.1016/j.apmr.2019.01.011DOI Listing
February 2019

Oxidative and Toxicological Evolution of Engineered Nanoparticles with Atmospherically Relevant Coatings.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

The health impacts associated with engineered nanoparticles (ENPs) released into the atmosphere have not been adequately assessed. Such impacts could potentially arise from the toxicity associated with condensable atmospheric secondary organic material (SOM), or changes in the SOM composition induced by ENPs. Here, these possibilities are evaluated by investigating the oxidative and toxicological evolution of TiO2 and SiO2 nanoparticles which have been coated with SOM from the O3 or . Read More

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http://dx.doi.org/10.1021/acs.est.8b06879DOI Listing
February 2019

The Developmental Characteristics for the Head Capsule Width of Monochamus alternatus (Coleoptera: Cerambycidae) Larvae and Determination of the Number of Instars.

J Insect Sci 2019 Jan;19(1)

Major of Plant Resources Science and Environment, College of Agriculture & Life Sciences, SARI, Jeju National University, Jeju, South Korea.

The objective of this study was to determine the number of instars of Monochamus alternatus Hope (Coleoptera: Cerambycidae) larvae by comparing their head capsule widths (HCW) published in previous studies, as well as additional laboratory experiments. Larvae of M. alternatus showed repeated molting in the laboratory. Read More

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http://dx.doi.org/10.1093/jisesa/iez010DOI Listing
January 2019

Male Bicyclus anynana Butterflies Choose Females on the Basis of Their Ventral UV-Reflective Eyespot Centers.

J Insect Sci 2019 Jan;19(1)

Department of Biological Sciences, National University of Singapore, Singapore.

Butterflies often use their dorsal and ventral wing color patterns for distinct signaling functions. Color patterns on hidden dorsal wing surfaces are often used in sexual signaling, while exposed ventral patterns are often used to ward off predator attacks. At rest, however, part of the ventral forewings are often hidden by the hindwings, allowing individuals to also use the patterns on this wing surface for sexual signaling. Read More

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http://dx.doi.org/10.1093/jisesa/iez014DOI Listing
January 2019

Influence of Pheromone-Baited Traps on Stink Bugs in Cotton.

J Insect Sci 2019 Jan;19(1)

Southeastern Fruit and Tree Nut Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Byron, GA.

Stink bugs (Hemiptera: Pentatomidae) are economic pests in fruit, vegetable, grain, and row crops worldwide. Pyramid traps baited with lures of stink bug aggregation pheromones capture these pests in the field, but stink bugs can congregate on plants near traps. Our specific objective was to examine the area of arrestment of stink bugs based on their density on cotton at different distances from pheromone-baited traps. Read More

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http://dx.doi.org/10.1093/jisesa/iey140DOI Listing
January 2019

Next generation strategies for geroprotection via mTORC1 inhibition.

J Gerontol A Biol Sci Med Sci 2019 Feb 22. Epub 2019 Feb 22.

William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

Inhibition of mTORC1 (mechanistic Target Of Rapamycin Complex 1) with the pharmaceutical rapamycin prolongs the lifespan and healthspan of model organisms including rodents, with evidence now emerging that rapamycin and its analogs may also have rejuvenative effects in dogs and humans. However, the side effects associated with long-term rapamycin treatment, many of which are due to inhibition of a second mTOR complex, mTORC2, have seemed to preclude the routine use of rapamycin as a therapy for age-related diseases. Here, we discuss recent findings suggesting that strong, chronic inhibition of both mTOR complexes may not be necessary to realize the geroprotective effects of rapamycin. Read More

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http://dx.doi.org/10.1093/gerona/glz056DOI Listing
February 2019

Renal iron accumulation and oxidative injury with aging: effects of treatment with an iron chelator.

J Gerontol A Biol Sci Med Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Health and Human Physiology, The University of Iowa.

Dysregulation of iron metabolism in the kidney may contribute to age-related increases in renal oxidative stress and dysfunction. This study assessed the effects of short-term iron chelation on markers of iron status, oxidative stress, inflammation, and autophagy in the kidneys of old rats. Old Fischer 344 rats (24 mo) were treated with deferoxamine (DFO; 200 mg/kg, twice daily for 4. Read More

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http://dx.doi.org/10.1093/gerona/glz055DOI Listing
February 2019

Implications of Classification of Os Trigonum: A Study Based on Computed Tomography Three-Dimensional Imaging.

Med Sci Monit 2019 Feb 22;25:1423-1428. Epub 2019 Feb 22.

Department of Orthopedic, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).

BACKGROUND The os trigonum is an accessory bone that is not fully fused with the talus during secondary ossification, and is one of the risk factors of posterior malleolus impact syndrome. The purpose of this study was to classify the os trigonum and to guide the diagnosis and treatment of related clinical diseases. MATERIAL AND METHODS Ankle computed tomography (CT) scans of 586 Chinese patients between October 2014 and October 2018 were reviewed. Read More

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http://dx.doi.org/10.12659/MSM.914485DOI Listing
February 2019

Enhancement of bone consolidation using high-frequency pulsed electromagnetic fields (HF-PEMFs): An experimental study on rats.

Bosn J Basic Med Sci 2019 Feb 20. Epub 2019 Feb 20.

"Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

In vitro studies showed that high-frequency pulsed electromagnetic fields (HF-PEMFs) increase the activity/expression of early and late osteogenic markers and enhance bone mineralization. The main aim of this study was to investigate the in vivo effects of HF-PEMFs on fracture healing using a rat model. A femur fracture was established by surgery in 20 male Wistar rats. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3854DOI Listing
February 2019

Haplotype-phased genome assembly of virulent Phythophthora ramorum isolate ND886 facilitated by long-read sequencing reveals effector polymorphisms and copy number variation.

Mol Plant Microbe Interact 2019 Feb 22. Epub 2019 Feb 22.

Indian Institute of Chemical Biology CSIR, 30156, Structural Biology and bioinformatics, Kolkata, West Bengal, India.

Phytophthora ramorum is a destructive pathogen that causes Sudden Oak Death. The genome sequence of P. ramorum isolate Pr102 was previously produced using Sanger reads, and contained 12 Mb of gaps. Read More

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http://dx.doi.org/10.1094/MPMI-08-18-0222-RDOI Listing
February 2019

Catalyzed Gasoline Particulate Filters Reduce Secondary Organic Aerosol Production from Gasoline Direct Injection Vehicles.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

The effects of photochemical aging on exhaust emissions from two light-duty vehicles with gasoline direct injection (GDI) engines equipped with and without catalyzed gasoline particle filters (GPFs) were investigated using a mobile environmental chamber. Both vehicles with and without the GPFs were exercised over the LA92 drive cycle using a chassis dynamometer. Diluted exhaust emissions from the entire LA92 cycle were introduced to the mobile chamber and subsequently photochemically reacted. Read More

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http://dx.doi.org/10.1021/acs.est.8b06418DOI Listing
February 2019

Reducing indoor levels of 'outdoor PM2.5' in urban China: impact on mortalities.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

This study estimates adult mortalities attributed to PM2.5 across urban China in 2015 and the corresponding mortalities that might be avoided by meeting the yearly-averaged indoor PM2.5 threshold in the newly established Assessment Standard for Healthy Building (ASHB) and seven other potential thresholds. Read More

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http://dx.doi.org/10.1021/acs.est.8b06878DOI Listing
February 2019

Sorption of nonionic aromatic organics to mineral micropores: Interactive effect of cation hydration and mineral charge density.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

The influence of K+ and Ca2+ on the sorption of nonionic aromatic contaminants (1,4-dinitrobenzene and p-xylene) on a series of microporous zeolite minerals (HZSM-5) with various surface charge densities were investigated. For zeolites with high or low charge density (> 1.78 sites/nm2 or < 0. Read More

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http://dx.doi.org/10.1021/acs.est.9b00145DOI Listing
February 2019

Antioxidant and Antiproliferative Activities of Modified Polysaccharides Originally Isolated from Morchella Angusticepes Peck.

J Food Sci 2019 Feb 22. Epub 2019 Feb 22.

College of Food Science, Southwest Univ., Chongqing, 400715, People's Republic of China.

Polysaccharides extracted from Morchella angusticepes Peck (PMEP) were chemically modified to obtain sulfated, carboxymethylated, and acetyled derivatives. Results showed that the acetyled derivatives with the degree of substitution (0.40 ± 0. Read More

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http://dx.doi.org/10.1111/1750-3841.14470DOI Listing
February 2019

Low-Dose Testosterone and Evoked Resistance Exercise after Spinal Cord Injury [TEREX-SCI] on Cardio-metabolic Risk Factors: An open-label randomized clinical trial.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

McGuire VA Medical Center, Endocrinology & Metabolism, Richmond, Virginia, United States ;

The purpose of the work is to investigate the effects of low-dose testosterone replacement therapy (TRT) and evoked resistance training (RT) on body composition and metabolic variables after SCI. Twenty-two individuals with chronic motor complete SCI (ages 18-50 years) were randomly assigned to either TRT+RT (n = 11) or TRT (n = 11) for 16 weeks following a 4 -week delayed entry period. TRT+RT men underwent twice weekly progressive RT using electrical stimulation with ankle weights. Read More

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http://dx.doi.org/10.1089/neu.2018.6136DOI Listing
February 2019

An 'experimental' instrument: testing the torsion balance in Britain, Canada and Australia.

Ann Sci 2019 Feb 22:1-29. Epub 2019 Feb 22.

a Humanities , York University , Toronto , Canada.

The torsion balance, an instrument that was first developed to demonstrate the high precision of physical science in the laboratory became a different sort of demonstration instrument in its brief vogue in the 1920s. This article considers intersecting stories of acquiring and testing the torsion balance as a field instrument in Canada, Britain and Australia. It examines the purchasing trip and fieldwork of A. Read More

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http://dx.doi.org/10.1080/00033790.2019.1578897DOI Listing
February 2019

Food or nutrient pattern assessment using the principal component analysis applied to food questionnaires. Pitfalls, tips and tricks.

Int J Food Sci Nutr 2019 Feb 22:1-11. Epub 2019 Feb 22.

a Centre of Excellence for Nutrition (CEN), North-West University , Potchefstroom , South Africa.

We considered the Blom's transformation, a statistical method aimed to normalise and standardise food intakes before principal component analysis. A simulation study was performed to evaluate the eigenvalue distribution of a correlation matrix under common conditions in food questionnaire analysis. The scree plot visual inspection and the Guttman-Kaiser (GK) criterion were compared to Horn's parallel analysis to evaluate their efficacy in food pattern identification. Read More

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http://dx.doi.org/10.1080/09637486.2019.1566445DOI Listing
February 2019

Specific brain morphometric changes in spinal cord injury: a voxel-based meta-analysis of white and grey matter volume.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

105# jiefang roadJinan, Shandong, China , 250013 ;

We want to investigate degenerative changes of white matter volume (WMV) and grey matter volume (GMV) in individuals after a spinal cord injury (SCI). Published studies of whole-brain voxel-based morphometry (VBM) comparing SCI patients with controls published between 2006 and March 1st, 2018 were collected by searching PubMed, Web of Science, and EMBASE databases. Voxel-wise meta-analyses of GMV and WMV differences between SCI patients and controls were performed separately using seed-based d mapping. Read More

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http://dx.doi.org/10.1089/neu.2018.6205DOI Listing
February 2019

Real-time monitoring and control of urea hydrolysis in cyber-enabled nonwater urinal system.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

This research used a cyber-physical system (CPS) to monitor and control the extent of urea hydrolysis in nonwater urinals. Real-time pH and conductivity data were used to control urea hydrolysis inhibition under realistic restroom conditions with acetic acid addition. Variable urination frequencies and urination volumes were used to compare three conditions that affect the progression of urea hydrolysis. Read More

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http://dx.doi.org/10.1021/acs.est.8b06126DOI Listing
February 2019

Phthalates and phthalate alternatives have diverse associations with oxidative stress and inflammation in pregnant women.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

Exposure to environmental chemicals such as phthalates has been linked to numerous adverse pregnancy outcomes, potentially through an oxidative stress mediated mechanism. Most research examined urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) as the oxidative stress biomarker. However, 8-iso-PGF2α also originates from enzymatic sources linked to inflammation. Read More

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http://dx.doi.org/10.1021/acs.est.8b05729DOI Listing
February 2019

Complex Mixtures of Brominated/Chlorinated Diphenyl Ethers and Dibenzofurans in Soils from the Agbogbloshie E-waste Site (Ghana): Occurrence, Formation and Exposure Implications.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

The distribution and toxic equivalents (TEQs) of brominated, chlorinated dibenzo-p-dioxins/dibenzofurans (PBDD/Fs and PCDD/Fs) in soils from Agbogbloshie e-waste site (Ghana) were investigated. The composition of brominated/chlorinated dibenzofurans (PXDFs) and diphenyl ethers (PBDEs, PCDEs and PXDEs) were examined using two-dimensional gas chromatography-time-of-flight mass spectrometry to elucidate possible formation pathways of dioxins from e-waste recycling. The highest concentrations of PCDD/Fs and PBDD/Fs were found respectively in the open burning (1. Read More

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http://dx.doi.org/10.1021/acs.est.8b06929DOI Listing
February 2019

High-resolution datasets unravel the effects of sources and meteorological conditions on nitrate and its gas-particle partitioning.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

The formation of nitrate in ambient atmosphere, one of the most abundant inorganic water-soluble ions in fine particulate matter (PM2.5), is difficult to clear explore by its semi-volatility, the various existing forms of "N" and pathways associated with its formation. In this study, hourly ambient observations (NO3-, SO42-, etc. Read More

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http://dx.doi.org/10.1021/acs.est.8b06524DOI Listing
February 2019

Dynamical Correlations for Statistical Copolymers from High-Throughput Broad-Band Dielectric Spectroscopy.

ACS Comb Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemical and Biomedical Engineering , University of South Florida , Tampa , Florida 33620 , United States.

Broad-band dielectric spectroscopy (BDS) provides a powerful method of characterizing relaxation dynamics in diverse materials. Here we describe and employ a novel instrument for high-throughput broad-band dielectric spectroscopy (HTBDS) that accelerates this capability, enabling simultaneous measurements of 48 samples. This capability is based around a coaxial switching system for rapid scanning between multiple samples on the same sample stage, coordinated with shared environmental control. Read More

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http://dx.doi.org/10.1021/acscombsci.8b00160DOI Listing
February 2019

The Spectrum of Learning and Teaching: The Impact of a Fourth-Year Anatomy Course on Medical Student Knowledge and Confidence.

Anat Sci Educ 2019 Feb 22. Epub 2019 Feb 22.

Department of Physical Therapy, Northeastern University, Boston, Massachusetts.

There is growing demand from accrediting agencies for improved basic science integration into fourth-year medical curricula and inculcation of medical students with teaching skills. The objective of this study was to determine the effectiveness of a fourth-year medical school elective course focused on teaching gross anatomy on anatomical knowledge and teaching confidence. Fourth-year medical student "teacher" participants' gross anatomy knowledge was assessed before and after the course. Read More

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http://dx.doi.org/10.1002/ase.1872DOI Listing
February 2019

Acute kidney injury after hepatectomy can be reasonably predicted after surgery.

J Hepatobiliary Pancreat Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Anesthesiology, Columbia University Medical Center, New York, NY.

Background: Hepatectomy presents unique challenges potentially heightening acute kidney injury risk, but the full spectrum of risk factors have not been identified.

Methods: Data for hepatectomy patients in the 2016 American College of Surgeons National Surgical Quality Improvement Program (N=3814) was randomly split into derivation (70%) and validation (30%) cohorts. AKI was defined as an increase in serum creatinine ≥0. Read More

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http://dx.doi.org/10.1002/jhbp.615DOI Listing
February 2019

A Review on Analytical Methods for Natural Berberine Alkaloids.

J Sep Sci 2019 Feb 22. Epub 2019 Feb 22.

Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Berberine alkaloids, a group of protoberberine alkaloids under the classification of isoquinoline alkaloids, include berberine, coptisine, palmatine, columbamine, dehydrocorydaline, jatrorrhizine and epiberberine from natural sources. Studies have shown that berberine alkaloids have various pharmacological functions, such as antibacterial, antiviral, blood pressure-lowering, hypoglycaemic, antiarrhythmia and anticancer effects. Therefore, it is worthwhile to develop analytical methods to investigate the pharmacokinetics and activity mechanisms of berberine alkaloids and to study berberine alkaloids more comprehensively. Read More

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http://dx.doi.org/10.1002/jssc.201800952DOI Listing
February 2019

A fibrinous and allogeneic fibroblast-enriched membrane as a biocompatible material can improve diabetic wound healing.

Biomater Sci 2019 Feb 22. Epub 2019 Feb 22.

Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran. and Department of Hematology and Laboratory Sciences, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran.

The application of conventional approaches to diabetic wound regeneration has some limitations. Thus, skin substitutes could be a new therapeutic possibility. In this regard, fibrin scaffolds are promising materials due to their desirable characteristics. Read More

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http://dx.doi.org/10.1039/c8bm01377bDOI Listing
February 2019

Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Proliferation and Metastasis of Osteosarcoma Cells by Targeting c-Met and SOX4 via miR-34a/c-5p and miR-449a/b.

Med Sci Monit 2019 Feb 22;25:1410-1422. Epub 2019 Feb 22.

Department of Hand Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).

BACKGROUND Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a functional long non-coding RNA involved in many biologic processes. The study was aimed to explore the functional roles of MALAT1 in osteosarcoma progression. MATERIAL AND METHODS A total of 76 osteosarcoma tissues and paired adjacent non-tumor tissues were collected from surgical resection. Read More

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https://www.medscimonit.com/abstract/index/idArt/912703
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http://dx.doi.org/10.12659/MSM.912703DOI Listing
February 2019
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Dechlorination-Hydroxylation of Atrazine to Hydroxyatrazine with Thiosulfate: A Detoxification Strategy in Seconds.

Environ Sci Technol 2019 Feb 22. Epub 2019 Feb 22.

Hydroxylation of atrazine to nontoxic hydroxyatrazine is generally considered as an efficient detoxification method to remediate atrazine-contaminated soil and water. However, previous studies suggested that hydroxylation was not the dominant pathway for atrazine degradation in the hydroxyl radical-generating systems such as Fenton reaction, ozone and UV/H2O2. Herein we report that the addition of sodium thiosulfate can realize rapid hydroxylation of atrazine to hydroxyatrazine at pH ≤ 4 under room temperature. Read More

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http://dx.doi.org/10.1021/acs.est.8b06351DOI Listing
February 2019

Anatomical Sciences in Chiropractic Education: A survey of Chiropractic Programs in Australia.

Anat Sci Educ 2019 Feb 21. Epub 2019 Feb 21.

Department of Anatomy, School of Medical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia.

Human anatomy knowledge is a core requirement for all health care clinicians. There is a paucity of information relating to anatomy content and delivery in Australian chiropractic programs. The aim of this study was to describe anatomy teaching in Australian chiropractic programs, utilizing a survey which was distributed to all four programs, requesting information on: anatomy program structure, delivery methods, assessment, teaching resources, and academic staff profile at their institution. Read More

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http://dx.doi.org/10.1002/ase.1871DOI Listing
February 2019

Separation of betacyanins from flowers of Amaranthus cruentus L. in a polar solvent system by high-speed counter-current chromatography.

J Sep Sci 2019 Feb 21. Epub 2019 Feb 21.

Department of Analytical Chemistry, Institute C-1, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Cracow, Poland.

Betacyanin extract of Amaranthus cruentus L. flowers was fractionated for the first time by semi-preparative high-speed counter-current chromatography in highly polar solvent system: Propan-1-ol - Acetonitrile - (NH ) SO - H O (1.0:0. Read More

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http://dx.doi.org/10.1002/jssc.201801172DOI Listing
February 2019

JumpDetector: An automated monitoring equipment for the locomotion of jumping insects.

Insect Sci 2019 Feb 22. Epub 2019 Feb 22.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Continuous jumping behavior, a kind of endurance locomotion, plays important roles in insect ecological adaption and survival. However, the methods used for the efficient evaluation of the insect jumping behavior remain largely lacking. Here, we developed a locomotion detection system named JumpDetector with automatic trajectory tracking and data analysis to evaluate the jumping of insects. Read More

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http://dx.doi.org/10.1111/1744-7917.12668DOI Listing
February 2019

Effects of different levels of dietary protein with or without plant extract YGF251 on growth performance, nutrient digestibility, blood profiles, fecal microbial shedding, and fecal gas emission in growing pigs.

Anim Sci J 2019 Feb 21. Epub 2019 Feb 21.

Department of Animal Resource and Science, Dankook University, Cheonan, Chungnam, South Korea.

This experiment was conducted to evaluate the effects of plant extract YGF251 supplementation in different protein level diets on growth performance, nutrient digestibility, blood profiles, fecal microbial shedding, and fecal gas emission in growing pigs. A total of 144 pigs (24.72 ± 1. Read More

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http://dx.doi.org/10.1111/asj.13162DOI Listing
February 2019

Effect of melatonin on regulation of apoptosis and steroidogenesis in cultured buffalo granulosa cells.

Anim Sci J 2019 Feb 21. Epub 2019 Feb 21.

Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agriculture University, Hubei Wuhan, China.

This study was aimed to address melatonin receptor expression, mRNA level of hypothalamus and hypophysis hormone receptors (GnRHR, FSHR, and LHR), steroidogenesis, cell cycle, apoptosis, and their regulatory factors after addition of melatonin for 24 hr in cultured buffalo granulosa cells (GCs). The results revealed that direct addition of different concentrations of melatonin (100 pM, 1 nM, and 100 nM) resulted in significant upregulation (p < 0.05) of mRNA level of melatonin receptor 1a (MT1) without affecting melatonin receptor 1b (MT2). Read More

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http://dx.doi.org/10.1111/asj.13152DOI Listing
February 2019

Novel Ca -independent carbohydrate recognition of the C-type lectins, SPL-1 and SPL-2, from the bivalve Saxidomus purpuratus.

Protein Sci 2019 Feb 22. Epub 2019 Feb 22.

Biomolecular Chemistry Laboratory, Graduate School of Engineering, Nagasaki University, Bunkyo-machi 1-14, Nagasaki, 852-8521, Japan.

Novel Ca -independent C-type lectins, SPL-1 and SPL-2, were purified from the bivalve Saxidomus purpuratus. They are composed of dimers with either identical (SPL-2 composed of two B-chains) or distinct (SPL-1 composed of A- and B-chains) polypeptide chains, and show affinity for N-acetylglucosamine (GlcNAc)- and N-acetylgalactosamine (GalNAc)-containing carbohydrates, but not for glucose or galactose. A database search for sequence similarity suggested that they belong to the C-type lectin family. Read More

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http://dx.doi.org/10.1002/pro.3592DOI Listing
February 2019

Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif.

Protein Sci 2019 Feb 21. Epub 2019 Feb 21.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.

We previously described structural and functional characterization of the first ubiquitin variant (UbV), UbV.v27.1, engineered by phage display to bind with high affinity to a specific ubiquitin interacting motif (UIM). Read More

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http://dx.doi.org/10.1002/pro.3593DOI Listing
February 2019

Concomitant disorder and high affinity zinc binding in the hZIP4 intracellular loop.

Protein Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA, 01609, USA.

The human (h)ZIP4 protein is the major plasma membrane protein responsible for the uptake of zinc in the body, and as such it plays a key role in cellular zinc homeostasis. hZIP4 plasma membrane levels are regulated through post-translational modification of its large, disordered, histidine-rich cytosolic loop (ICL2) in response to intracellular zinc concentrations. Here, structural characteristics of the isolated disordered loop region, both in the absence and presence of zinc, were investigated using NMR spectroscopy. Read More

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http://dx.doi.org/10.1002/pro.3591DOI Listing
February 2019

Sensory and Consumer Evaluation of Smoked Pulled Pork Prepared Using Different Smokers and Different Types of Wood.

J Food Sci 2019 Feb 21. Epub 2019 Feb 21.

The Sensory and Consumer Research Center, Kansas State Univ., 22201 W. Innovation Drive, Olathe, KS, 66061, USA.

Smoked and barbecued meats have continued to gain popularity in recent years, however, no consensus exists on the best methods for preparation. Several smoker types and many varieties of wood are used for smoking meat in the restaurant industry and by amateur "pit-masters." In this research, pork was smoked with an outdoor offset smoker and an indoor electric smoker using four wood types: hickory, apple, oak, and mesquite. Read More

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http://dx.doi.org/10.1111/1750-3841.14469DOI Listing
February 2019

Combined use of biochar and zinc oxide nanoparticle foliar spray improved the plant growth and decreased the cadmium accumulation in rice (Oryza sativa L.) plant.

Environ Sci Pollut Res Int 2019 Feb 22. Epub 2019 Feb 22.

Botany and Microbiology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.

The contamination of large areas of arable land with cadmium (Cd) is a serious concern worldwide and environmentally feasible amendments are necessary to minimize Cd accumulation in cereals such as rice (Oryza sativa L.). A pot study was, therefore, conducted to evaluate the efficiency of foliar spray of different levels (0, 50, 75, 100 mg/L) of zinc oxide nanoparticles (ZnO NPs) alone or combined with biochar (1. Read More

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http://dx.doi.org/10.1007/s11356-019-04554-yDOI Listing
February 2019

Effect of cation type in mixed Ca-Na systems on transport of sulfonamide antibiotics in saturated limestone porous media.

Environ Sci Pollut Res Int 2019 Feb 22. Epub 2019 Feb 22.

Key Laboratory of Surficial Geochemisty, Ministry of Education, School of Earth Sciences and Engineering, Nanjing University, Nanjing, 210023, China.

Retention and transport of sulfonamides (SAs) in subsurface can strongly affect groundwater quality. In this work, a range of laboratory batch sorption and column transport experiments were conducted to determine the effect of cation type in mixed Ca-Na systems on the retention and transport of two typical SAs, sulfadimethoxine (SDM) and sulfacetamide (SCA), in saturated limestone porous media. Column experimental data showed divalent cation Ca played a more important role than monovalent cation Na in decreasing the transport of only SDM in co-cation systems in the saturated limestone media. Read More

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http://dx.doi.org/10.1007/s11356-019-04561-zDOI Listing
February 2019

Enhanced adsorption of cationic Pb(II) and anionic Cr(VI) ions in aqueous solution by amino-modified nano-sized illite-smectite clay.

Environ Sci Pollut Res Int 2019 Feb 21. Epub 2019 Feb 21.

College of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, China.

A raw illite-smectite mixed-layered clay (RI/S) was ground for preparing nano-sized I/S clay (NI/S) and subsequently amino-functionalized via grafting of 3-aminopropyltrithoxysilane (APTES) (NH-RI/S and NH-NI/S, respectively). The samples were characterized by particle size analysis, specific surface area measurement, X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), and Si nuclear magnetic resonance (Si NMR). Compared to RI/S, NI/S has a narrow particle size distribution and appears in a platelet-like morphology due to the disintegration/exfoliation of RI/S after grinding. Read More

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http://dx.doi.org/10.1007/s11356-019-04447-0DOI Listing
February 2019
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