1,294,907 results match your criteria SCI Nursing[Journal]


Supplementation of Modified Mannitol-Yolk-Polymyxin B Agar with Cefuroxime for Quantitative Detection of Bacillus cereus in Food.

J Food Sci 2018 Dec 17. Epub 2018 Dec 17.

the Konkuk Univ., Hwayang-dong, Gwangjin-gu, Seoul, The Republic of Korea.

The presence of unwanted competing flora has been the most common confounding factor in the enumeration of Bacillus cereus (B. cereus) using selective media such as mannitol-yolk-polymyxin B agar (MYPA). The objective of this study was to improve MYPA selectivity for B. Read More

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December 2018

Formation of Clusters in Whiskies During the Maturation Process.

J Food Sci 2018 Dec 17. Epub 2018 Dec 17.

Inst. for Solid State Physics, The Univ. of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8581, Japan.

Maturation provides whisky with a mild and smooth texture by removing the irritating alcoholic flavor. However, the precise mechanism by which the whisky flavor is improved through the maturation process remains unknown. In this study, we performed mesoscopic structural measurements-dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS)-to elucidate the relationship between the liquid structure and flavor maturation of whiskies. Read More

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December 2018

Validation of a Rapid Microwave-Assisted Extraction Method and GC-FID Quantification of Total Branched Chain Fatty Acids in Lamb Subcutaneous Adipose Tissue.

J Food Sci 2018 Dec 17. Epub 2018 Dec 17.

School of Agriculture and Food Science, Univ. College Dublin, Belfield, Dublin, 4, Ireland.

A rapid microwave-assisted extraction and derivatization of three branched chain fatty acids (BCFA): 4-methyloctanoic acid (MOA), 4-ethyloctanoic acid (EOA) and 4-methylnonanoic acid (MNA) from subcutaneous adipose tissue (SAT) of lamb was developed and validated. Linearity was excellent (R > 0.99), and the limits of detection and quantification (μg/mL) were between 0. Read More

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December 2018

A Novel Method for Generation of a Fingerprint Using Electronic Nose on the Example of Rapeseed Spoilage.

J Food Sci 2018 Dec 17. Epub 2018 Dec 17.

Inst. of Agrophysics, Polish Academy of Sciences, ul. Doswiadczalna 4, 20-290, Lublin, Poland.

The paper presents application of a new three-parameter method for identification of volatile organic compounds (VOCs) and creation of fingerprints based on the impregnation time (t ), cleaning time (t ), and maximum response ([ΔR/R] ) of chemically sensing sensors for detecting spoilage of agricultural commodities. The novelty of this method consists in the use of two additional parameters: an impregnation time and a cleaning time for the first time. An Agrinose built of eight metal oxide semiconductors was used for identification of loss in the rapeseed quality during a short period of storage after harvest. Read More

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December 2018
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Phenolic Profiles, Antioxidant and Antimicrobial Activities of Pawpaw Pulp (Asimina triloba [L.] Dunal) at Different Ripening Stages.

J Food Sci 2018 Dec 17. Epub 2018 Dec 17.

Dept. of Microbiology and Molecular Biology, Chungnam Natl. Univ., 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Republic of Korea.

In this study, the phenolic components, as well as the antioxidant and antimicrobial activities, of the ripe and unripe fruit of pawpaw (Asimina triloba [L.] Dunal) extracted using five different solvents (distilled water, 95% methanol, 80% methanol, 95% ethanol, and 80% ethanol) were analyzed. The total phenolic content and total flavonoid content were the highest in the 95% ethanol (149. Read More

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December 2018

Effects of Hesperidin on H₂O₂-Treated Chondrocytes and Cartilage in a Rat Osteoarthritis Model.

Med Sci Monit 2018 Dec 17;24:9177-9186. Epub 2018 Dec 17.

Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).

BACKGROUND The purpose of this research was to investigate the effects of hesperidin on hydrogen peroxide (H₂O₂)-induced chondrocytes injury and cartilage degeneration in a rat model of osteoarthritis (OA). MATERIAL AND METHODS Chondrocytes were isolated from rat knee joints and treated with hesperidin alone or combined with H₂O₂. Then, Cell Counting Kit-8 (CCK-8) assay was used to assess cell viability. Read More

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December 2018
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Stability of synthetic cathinones in blood and urine.

Forensic Sci Int 2018 Dec 6;295:36-45. Epub 2018 Dec 6.

Jagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Kraków, Poland.

Introduction: Although there is an observed decline in the number of new psychoactive substances entering the drug market, this phenomenon is still a significant public health problem. Synthetic cathinones are the second largest group of new substances and currently belong to the most frequently confiscated. Their availability and prevalence cause that they are often abused. Read More

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December 2018
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Development of postural stability limits: Anteroposterior and mediolateral postural adjustment mechanisms do not follow the same maturation process.

Hum Mov Sci 2018 Dec 14;63:164-171. Epub 2018 Dec 14.

Département de Kinésiologie, Université de Montréal, 2100, boul. Édouard-Montpetit, Montréal, Québec H3T 1J4, Canada; Institut universitaire de gériatrie de Montréal, Université de Montréal, 2100, boul. Édouard-Montpetit, Montréal, Québec H3T 1J4, Canada. Electronic address:

There is increasing evidence that indicates a critical transition period for the maturation of postural control from the ages of 6-7 years. Some studies suggest that this transitional period may be explained by a change from a ballistic toward a sensory strategy, but the cause remains unknown. The purpose of this study was to investigate the influence of the transition period on dynamic postural control in a natural self-initiated leaning task under different sensory conditions. Read More

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December 2018

The role of neighborhoods in household food insufficiency: Considering interactions between physical disorder, low social capital, violence, and perceptions of danger.

Soc Sci Med 2018 Dec 10;221:58-67. Epub 2018 Dec 10.

The University of Texas at San Antonio, United States.

Rationale: Food insecurity is a significant public health concern, with implications for community and individual health and well-being. Although a growing body of literature points to the role of neighborhoods in household food insecurity, studies using nationally representative samples to explore interactions between neighborhood risks - including violence and danger - are lacking.

Objective: The present study examines whether interactions between physical disorder, low social capital, and violence/danger in the neighborhood have significant implications for the risk of household food insufficiency using a large, nationally representative sample of U. Read More

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December 2018

Discovering market segments for hunted wild game meat.

Meat Sci 2018 Nov 29;149:163-176. Epub 2018 Nov 29.

Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, Via Celoria, 10, 20133 Milano, Italy. Electronic address:

Recent years have seen a notable increase in the popularity of hunted wild game meat (HWGM) among consumers. This has led to a growing number of emerging markets for HWGM in many developed countries, including Europe. However, expansion of these markets is often hampered by the lack of a professional supply chain. Read More

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November 2018

Welfare assessment in rabbits raised for meat and laboratory purposes in enclosures with two floor types: Perforated plastic with holes versus slats.

Res Vet Sci 2018 Nov 13;122:200-209. Epub 2018 Nov 13.

Center for Biomedical Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address:

Due to welfare concerns and legal restrictions in certain countries, alternatives to wire net floors must be developed in rabbit husbandries. Also, there is a difference in regulations in Europe for laboratory rabbits vs. rabbits bred and kept for meat production. Read More

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November 2018

Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia.

Neurobiol Dis 2018 Dec 14. Epub 2018 Dec 14.

Kentucky Spinal Cord Injury Research Center, University of Louisville, School of Medicine, 511 S. Floyd St., MDR 616, Louisville, KY 40202, USA; Department of Anatomical Science & Neurobiology, University of Louisville, School of Medicine, 511 S. Floyd St., MDR 616, Louisville, KY 40202, USA.

Emerging evidence links changes in the gut microbiome and intestinal barrier function to alterations in CNS function. We examined the role of endotoxin-responsive, cAMP-specific, Pde4 subfamily b (Pde4b) enzyme in gut dysbiosis induced neuro-inflammation and white matter loss following spinal cord injury (SCI). Using a thoracic contusion model in C57Bl/6 wild type female mice, SCI led to significant shifts in the gut bacterial community including an increase in the phylum Proteobacteria, which consists of endotoxin-harboring, gram-negative bacteria. Read More

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December 2018

Mechanisms of poor oral bioavailability of flavonoid Morin in rats: From physicochemical to biopharmaceutical evaluations.

Eur J Pharm Sci 2018 Dec 14. Epub 2018 Dec 14.

School of Pharmaceutical Sciences, Zhengzhou University, No.100. Kexue Road, Zhengzhou, Henan Province 450001, China; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China. Electronic address:

We recently reported that the absolute oral bioavailability of flavonoid Morin was extremely low at 0.45%, resulting in unsatisfied therapeutic efficacy in vivo. The present study was aimed to systemically assess the pre-absorption risks of Morin for rationale formulation design. Read More

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December 2018
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Pre-formulation studies of the γ-cyclodextrin and montelukast inclusion compound prepared by co-milling.

J Pharm Sci 2018 Dec 14. Epub 2018 Dec 14.

QOPNA, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Montelukast (MLK), an oral anti-asthmatic drug with growing use, requires special care in formulation and storage to avoid its degradation by action of light and/or water. This work investigates the increase in the stability of montelukast as the effect of molecular encapsulation with gamma-cyclodextrin (γ-CD) by means of a solvent-free method, co-grinding. As a first step, a 1:1 preferred stoichiometry is established for this host-guest system using a combination of molecular modelling and the continuous variation method. Read More

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December 2018

Population Pharmacokinetic and Exposure-Response Analyses of Baloxavir Marboxil in Adults and Adolescents Including Influenza Patients.

J Pharm Sci 2018 Dec 14. Epub 2018 Dec 14.

Project Management Department, Shionogi & Co., Ltd, Osaka, Japan.

Purpose: Baloxavir marboxil, a prodrug that is metabolized to baloxavir acid, suppresses viral replication by inhibiting cap-dependent endonuclease. Our aim is to characterize its pharmacokinetics and exposure-response relationships.

Methods: Population pharmacokinetic analysis of baloxavir acid was performed using 8310 plasma concentration data points from 1109 subjects. Read More

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December 2018

Long non-coding RNA Hotair promotes gastric cancer progression via miR-217-GPC5 axis.

Life Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, The Affiliated YanAn Hospital of Kunming Medical University, Kunming, 650051, Yunnan, China. Electronic address:

Aims: The oncogenic role of lncRNA Hotair has been acknowledged in subset of malignancies, including gastric cancer (GC). However, the detailed molecular mechanisms that contribute to its oncogenic role of are largely elusive. This study was designed to explore the underlying mechanism that contributes the regulatory role of Hotair in GC pathogenesis and progression. Read More

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December 2018
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Fluvastatin-mediated down-regulation of SATB1 affects aggressive phenotypes of human non-small-cell lung cancer cell line H292.

Life Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Aims: Fluvastatin reduces tumor proliferation and increased apoptotic activity in various cancers. Special AT-rich sequence binding protein 1 (SATB1) is a genome organizer that reprogrammes the gene transcription profiles of tumors to promote growth and metastasis. The antitumor effect and molecular mechanisms of fluvastatin on lung cancer is poorly understood. Read More

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December 2018

Effect of High-Dose Statin Pretreatment for Myocardial Perfusion in Patients Receiving Percutaneous Coronary Intervention (PCI): A Meta-Analysis of 15 Randomized Studies.

Med Sci Monit 2018 Dec 17;24:9166-9176. Epub 2018 Dec 17.

Division of Nephrology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND For coronary artery disease, percutaneous coronary intervention (PCI) is the preferred treatment. Reperfusion injury is a common and serious complication of PCI. Studies showed that early statin therapy has a favorable prognostic impact for patients undergoing PCI. Read More

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December 2018
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In Reply: Encouraging a Bare Minimum While Striving for the Gold Standard: A Response to the Updated WHO-WFSA Guidelines.

Anesth Analg 2019 Jan;128(1):e13-e14

Department of Anesthesia & Perioperative Care University of California San Francisco, San Francisco, California University of Otago, Christchurch Hospital, Christchurch, New Zealand Services Organization and Clinical Interventions Unit (SCI), Service Delivery and Safety Department (SDS), Health Systems and Innovation (HIS), World Health Organization, Switzerland Department of Anaesthesiology, University of Auckland Department of Anaesthesia, Auckland City Hospital, Auckland, New Zealand.

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January 2019

The Transcriptional Signature of a Runner's High.

Med Sci Sports Exerc 2018 Dec 14. Epub 2018 Dec 14.

SUNY Upstate Medical University, Departments of Neuroscience & Physiology, Biochemistry & Molecular Biology, Pediatrics, and Psychiatry & Behavioral Sciences, Syracuse NY.

Introduction: Endorphins, endocannabinoids, monoamines, and neurotrophins have all been implicated in the euphoric response to endurance running, known as a runner's high. The epi-transcriptional mechanisms regulating this effect have not been defined. Here, we investigate peripheral micro-ribonucleic acid (miRNA) changes unique to athletes experiencing post-run euphoria, yielding insights about gene networks that control a runner's high. Read More

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December 2018

Effect of Endurance Training on Hemoglobin Mass and V˙O2max in Male Adolescent Athletes.

Med Sci Sports Exerc 2018 Dec 14. Epub 2018 Dec 14.

Section for Elite Sport, Swiss Federal Institute of Sport, Magglingen, Switzerland.

Purpose: It is unknown, whether endurance training stimulates hemoglobin mass (Hbmass) and V[Combining Dot Above]O2max increases during late adolescence. Therefore, this study assessed the influence of endurance training on Hbmass, blood volume parameters, and V[Combining Dot Above]O2max in endurance athletes and control subjects from age 16 to 19.

Methods: Hbmass, blood volume parameters, V[Combining Dot Above]O2max and anthropometric parameters were measured in male elite endurance athletes from age 16 to 19 in 6-month intervals (n=10), as well as in age-matched male controls (n=12). Read More

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December 2018

Contribution of High School Sport Participation to Young Adult Bone Strength.

Med Sci Sports Exerc 2018 Dec 14. Epub 2018 Dec 14.

Department of Preventative and Community Dentistry, College of Dentistry, University of Iowa, Iowa City, IA.

Introduction: Nearly 8 million American adolescents participate in sports. Participation declines in young adulthood.

Purpose: This study assessed longitudinal effects of high school sport participation and muscle power on young adult bone strength. Read More

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December 2018
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Nature's Fractal Similarities: Integrating Art and Science.

Authors:
Richard P Taylor

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):173-176

University of Oregon, Eugene OR.

This year's cover artist, Clinton Marstall, creates fractal imagery by photographing natural patterns. He then uses a pen to highlight the patterns and projects them on to a canvas for painting. Using this precision technique, he integrates a number of biomorphic images into a unique amalgum of multi-scaled complexity. Read More

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January 2019

The Temporal Dimension in Maternal Sensitivity Predicting Organized Attachment in Children.

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):137-171

National Distance Education University, Madrid, Spain.

This study analyzed Maternal Sensitivity in the interaction of mother-infant dyads to distinguish different dynamics associated with their attachment group membership - Insecure-Avoidant (A), Secure (B), or Insecure-Resistant (C), with no Disorganized traits - that they developed at 15 months. Participants were 26 eight-month old infants interacting with their mothers in a free-play setting. The analyses used sequential streams of infant actions and maternal responses, and state-space grids to study the temporal organization of the sequences. Read More

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January 2019

Monitoring Nonlinear Dynamics of Change in a Single Case of Psychodynamic Play Therapy.

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):113-135

Sapienza University of Rome, Italy and NCU Italian University, London, UK.

A systematic single case study with a mixed quantitative and qualitative methodology was conducted to investigate the nonlinear dynamics of change in play profiles of a child in psychodynamic play therapy. The first aim of the study was to cluster the different features of play characteristics (i.e. Read More

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January 2019
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A Nonlinear Dynamic Systems Model of Psychotherapy: First Steps Toward Validation and the Role of External Input.

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):79-112

Paracelsus Medical University, Salzburg, Austria.

Mathematical modeling and computer simulations are important means to understand the mechanisms of psychotherapy. The challenge is to design models which not only predict outcome, but simulate the nonlinear trajectories of change. Another challenge is to validate them with empirical data. Read More

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January 2019

Fractal Self-Structure and Psychological Resilience.

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):57-78

Chapman University, Orange, CA.

Since the mid 1980's, mainstream social psychology investigations of self-complexity and psychopathology have produced contradictory results. These results are likely the result of a lack of theoretical and methodological grounding in complexity theory. The current study proposes that the self has an interconnected fractal structure, and that this structure may be reflected within inverse-power law (IPL) distributions of response times to self-related questions. Read More

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January 2019

Nonlinear Indices with Applications to Schizophrenia and Bipolar Disorder.

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):17-56

Western University, London, ON, Canada.

In this article we study the application of nonlinear indices (sometimes called complexity indices) to univariate time series data arising from studies of schizophrenia and bipolar disorder. Specifically, we consider time series arising from EEG studies, ECG studies, and self-report mood data. As part of our analysis, we empirically examine the claim in the literature that complexity tends to be higher in the EEG of schizophrenia patients than controls and that this tendency is dampened or even inverted by medication, increasing age, and reduced symptomatology. Read More

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January 2019
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Clinical Psychology at the Crossroads: An Introduction to the Special Issue on Nonlinear Dynamical Systems.

Authors:
David Pincus

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):1-15

Chapman University, Orange CA.

This introduction to a special issue of Nonlinear Dynamics, Psychology and Life Sciences discusses the contributing articles within the issue from a variety of perspectives. This analysis examines each article's contribution to understanding the self, and to exploring the application of innovative nonlinear methods to clinical questions. Moving beyond the special issue, the analysis examines the role of nonlinear science in clinical psychology from the perspective of Aristotle's four types of cause: material, efficient, formal and teleological. Read More

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January 2019

Well on wheels intervention: Satisfaction with life and health for adults with spinal cord injuries.

J Spinal Cord Med 2018 Dec 17:1-9. Epub 2018 Dec 17.

c Department of Physical Medicine and Rehabilitation , University of Michigan , Ann Arbor , Michigan , USA.

Objective/background: To examine how demographic and injury characteristics identify satisfaction with life (SWL), and assess the differential effects of a wellness intervention by baseline SWL groups.

Design: Baseline and longitudinal analysis of a randomized controlled pilot intervention using decision tree regression and linear mixed models.

Setting: Community based. Read More

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December 2018

A Robust Neural Index of High Face Familiarity.

Psychol Sci 2018 Dec 17:956797618813572. Epub 2018 Dec 17.

2 Department of Psychology, University of York.

Humans are remarkably accurate at recognizing familiar faces, whereas their ability to recognize, or even match, unfamiliar faces is much poorer. However, previous research has failed to identify neural correlates of this striking behavioral difference. Here, we found a clear difference in brain potentials elicited by highly familiar faces versus unfamiliar faces. Read More

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December 2018

Advancing primary and community care for persons with spinal cord injury: Key findings from a Canadian summit.

J Spinal Cord Med 2018 Dec 17:1-11. Epub 2018 Dec 17.

e Rick Hansen Institute , Vancouver , Canada.

Context: Persons with spinal cord injury (SCI) experience significant challenges when they access primary care and community services.

Design: A provincial summit was held to direct research, education, and innovation for primary and community care for SCI.

Setting: Toronto, Ontario, Canada. Read More

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December 2018
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Enhanced chlorine and bromine atom activation by hydrolysis of halogen nitrates from marine aerosols at polluted coastal areas.

Environ Sci Technol 2018 Dec 17. Epub 2018 Dec 17.

Detailed multiphase chemistry box model studies are carried out, investigating halogen radical activation at polluted coastal areas. Simulations are performed for a non-permanent cloud and a cloud-free scenario and reveal that ClNO photolysis as well as ICl photolysis is crucial for gas-phase Cl atom activation. In the cloud scenario, the integrated ClNO and ICl photolysis rates are 3. Read More

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December 2018

Factions Influencing the Filing of Complaints, Their Investigation, and Subsequent Legal Judgment in Cases of Sexual Assault.

J Forensic Sci 2018 Dec 17. Epub 2018 Dec 17.

University Center of Legal Medicine, Geneva and Lausanne, Geneva site de Genève, 1 rue Michel Servet, 1211, Genève 4, Switzerland.

In Geneva, examination of victims of sexual assault is performed by a gynecologist and a medical examiner. 48% of the victims file a complaint and we wanted to investigate the factors leading to file a complaint, those leading the Prosecutor to go to trial, and those influencing a conviction. Between 2006 and 2012, 676 victims of sexual assault were investigated (averaged age 26 year, mean 22). Read More

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December 2018

Nutritional strategies for psoriasis: current scientific evidence in clinical trials.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8537-8551

Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Objective: Several nutritional strategies for the management of psoriasis are promising. Even if recent data support that nutrition may play a pivotal role in prevention and co-treatment and despite patient's concerns regarding the best nutritional habits, the consensus regarding the nutritional strategies to be adopted lacks in clinical settings. In this manuscript, the effects of several nutritional strategies for psoriasis patients such as hypocaloric diet, vitamin D, fish oil, selenium, and zinc supplementation were systematically reviewed. Read More

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December 2018
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Discovery and identification of fatigue-related biomarkers in human saliva.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8519-8536

Hebei University of Engineering, Affiliated Hospital, College of Medicine, Handan, China.

Objective: To identify stable and specific biomarkers/biomarker combinations for fatigue assessment and establish a discriminant model.

Patients And Methods: Saliva was collected and electroencephalogram analysis was performed for 47 emergency physicians while awake and after continuoutas duty for 18-24 h. Physicians were divided into the fatigue and non-fatigue groups. Read More

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December 2018
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Retigabine protects the blood-brain barrier by regulating tight junctions between cerebral vascular endothelial cells in cerebral ischemia-reperfusion rats.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8509-8518

Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Objective: To investigate the effect of retigabine on the blood-brain barrier permeability in rats with cerebral ischemia-reperfusion and its mechanism.

Materials And Methods: A total of 90 Sprague-Dawley (SD) rats were selected to prepare a rat model of focal cerebral ischemia-reperfusion. The blood flow changes were detected using a laser Doppler flow meter, the percentage of the cerebral infarction volume was measured by means of the triphenyl tetrazolium chloride (TTC) staining, the effect of retigabine on the permeability of the blood-brain barrier after cerebral ischemia-reperfusion was examined via Evans blue (EB) staining, and the state of tight junctions between endothelial cells was determined via the transmission electron microscopy (TEM) technique. Read More

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December 2018

Efficacy and safety of dronedarone in patients with amiodarone-induced hyperthyroidism: a clinical study.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8502-8508

Division of Cardiology, University of Rome Tor Vergata, Rome, Italy.

Objective: The aim of the study was to examine the safety and efficacy of dronedarone in patients with a history of atrial fibrillation and amiodarone-induced hyperthyroidism.

Patients And Methods: We conducted a prospective study to evaluate the use of amiodarone and dronedarone in 124 patients with a history of paroxysmal atrial fibrillation who had no additional structural heart disease. All patients received amiodarone 200 mg qd. Read More

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December 2018

99mTc-diphosphonates bone scintigraphy for vitality evaluation in cleft palate.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8497-8501

Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.

Cleft of the lip, palate and alveolus are congenital oro-maxillofacial malformation with an established treatment protocol. At present, there is great interest in the alveolar bone grafting procedures that involve the use of platelet-rich-plasma (PRP), to enhance bone formation and specifically to promote bone graft healing in head and neck tissues regeneration. The aim of this retrospective case report study was to assess the condition and viability of the standard bone grafting in association with PRP (platelet rich plasma) to enhance osteogenesis and maintain osteointegration in alveolar cleft with a follow up of eight years from the surgical procedure. Read More

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December 2018

Non-steroidal anti-inflammatory drugs increase MRP4 expression in an endometriotic epithelial cell line in a PPARa dependent manner.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8487-8496

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Objective: Endometriosis is a debilitating disease characterized by chronic inflammation. The transporter multidrug resistance-associated protein 4 (MRP4/ABCC4) is expressed in human endometrial tissue; it is overexpressed in ectopic endometrial tissue, and is modulated by the anti-inflammatory lipid Lipoxin A4 (LXA4). Recently, it was demonstrated that aspirin induces platelet MRP4 over-expression, through genomic modulation in megakaryocytes. Read More

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December 2018

Vaginal natural oxygenation device (VNOD) for concomitant administration of hyaluronic acid and topical hyperbaric oxygen to treat vulvo-vaginal atrophy: a pilot study.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8480-8486

Ospedale Civile Urbino - SSD Oncologia Ginecologica, Urbino, Italy.

Objective: This is a pilot study to evaluate the effectiveness of concomitant administration of hyaluronic acid and topical hyperbaric oxygen therapy (THOT) by a specifically designed medical device (vaginal natural oxygenation device, VNOD) in improving the symptomatology of postmenopausal patients with vulvo-vaginal atrophy (VVA).

Patients And Methods: Women with diagnosis of severe VVA from September 2017 to May 2018 were included. Five biweekly administration of THOT and concomitant of hyaluronic acid were performed with a specifically designed medical device. Read More

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December 2018

The association of the rs670 variant of APOA1 gene with insulin resistance and lipid profile in morbid obese patients after a biliopancreatic diversion surgery.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8472-8479

Department of Endocrinology and Nutrition, Endocrinology and Nutrition Research Center, School of Medicine, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.

Objective: A common G-to-A transition (rs670) of the Apoprotein subtype 1 APOA1 gene has been evaluated. The presence of the A allele has been related with increased activity. We investigated the role of this genetic variant (rs670) on lipoprotein levels and anthropometric parameters after biliopancreatic diversion (BPD) surgery in morbid obese patients. Read More

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December 2018

Overexpression of miR-638 attenuated the effects of hypoxia/reoxygenation treatment on cell viability, cell apoptosis and autophagy by targeting ATG5 in the human cardiomyocytes.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8462-8471

Clinical Research Center, The Second Clinical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.

Objective: Myocardial ischemia/reperfusion (I/R) injury largely contributed to the damage of myocardial tissues in patients with coronary disease, which may subsequently lead to heart failure. MicroRNAs (miRNAs) are considered to be involved in the process of myocardial I/R injury. The present study aimed to investigate the in vitro functional role of miR-638 in the myocardial I/R injury in the human cardiomyocytes (HCMs). Read More

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December 2018

miRNA-130a improves cardiac function by down-regulating TNF-α expression in a rat model of heart failure.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8454-8461

Department of Cardiovascular Medicine, The First College of Clinical Medical Science, Three Gorges University, China; Yichang Central People's Hospital, Yichang City, Hubei Province, China.

Objective: To investigate the effect of MicroRNA (miRNA)-130a on cardiac function and the expression of tumor necrosis factor-α (TNF-α) in rats with heart failure.

Materials And Methods: The rat heart failure model (n = 30) were established, then divided into miRNA-130a group, phosphate-buffer saline (PBS) group, rAAV9 group, and sham group (n = 10 in each group). Four weeks after the operation, the cardiac ultrasound and hemodynamic determination were performed. Read More

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December 2018

GAS5 promotes myocardial apoptosis in myocardial ischemia-reperfusion injury via upregulating LAS1 expression.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8447-8453

Department of Cardiovascular Surgery, the First Affiliated Hospital, Harbin Medical University, Harbin, China.

Objective: This study aims at investigating whether GAS5 (grow arrest-specific 5) could promote cardiomyocyte apoptosis by upregulating LAS1 expression, thereby participating in the development of myocardial ischemia-reperfusion injury.

Materials And Methods: The expression level of GAS5 in H9c2 cells after hypoxia/reoxygenation (H/R) treatment was detected by quantitative Real time-polymerase chain reaction (qRT-PCR). Myocardial injury markers in H9c2 cells were evaluated using relative commercial kits, including activities of LDH (lactate dehydrogenase), MDA (malondialdehyde), SOD (superoxide dismutase) and GSH-PX (glutathione peroxidase). Read More

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December 2018

MicroRNA-218 prevents lung injury in sepsis by inhibiting RUNX2.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8438-8446

Department of Critical Care Medicine, Dongying People's Hospital, Dongying, Shandong Province, China.

Objective: To explore the regulatory effects of microRNA-218 on lung tissue of rats with acute lung injury (ALI) and its underlying mechanism.

Materials And Methods: A total of 32 Sprague Dawley (SD) rats were randomly divided into control group, lung injury group and microRNA-218 treatment group. The in vitro lung injury model was established by injections of lipopolysaccharide (LPS), PGN (peptidoglycan) and IgG IC (immune complex). Read More

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December 2018
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Expressions of MiR-132 in patients with chronic hepatitis B, posthepatitic cirrhosis and hepatitis B virus-related hepatocellular carcinoma.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8431-8437

Department of Medical Technology, Xi'an Medical University, Xi'an, China.

Objective: To explore the expressions of miR-132 in patients with chronic hepatitis B, posthepatitic cirrhosis and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), and to investigate its possible mechanism affecting the function of the body.

Patients And Methods: Among 125 patients with HBV, there were 44 cases of chronic hepatitis, 42 cases of liver cirrhosis and 39 cases of liver cancer. Their liver function and HBV-deoxyribonucleic acid (HBV-DNA) viral load as well as the expressions of micro ribonucleic acid-132 (miR-132), phosphoinositide 3-kinase (PI3K), phosphorylated-protein kinase B (p-Akt) and hepatitis B X protein (HBx), were detected. Read More

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December 2018

MiR-212-5p regulates the proliferation and apoptosis of AML cells through targeting FZD5.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8415-8422

Department of Hematology and Rheumatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objective: To explore the effects of microRNA-212-5p (miR-212-5p) on biological functions of acute myeloid leukemia (AML) and to find the potential molecular mechanism.

Patients And Methods: We measured the expression level of miR-212-5p in 35 AML patients and 20 patients with idiopathic thrombocytopenic purpura (ITP) as control cases. Besides, the miR-212-5p expression at cellular level was checked as well. Read More

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December 2018

Upregulation of long noncoding RNA MRCCAT1 predicts poor prognosis and functions as an oncogene in glioma.

Authors:
J Ma L-J Su Z-J Zheng

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8406-8414

Department of Neurology, Ningbo Yinzhou No. 2 Hospital, Ningbo, Zhejiang, China.

Objective: This study aimed to investigate the expressions, clinical significances, roles, and mechanism of action of MRCCAT1 in glioma.

Patients And Methods: The expression of MRCCAT1 in 103 glioma tissues with different grades and 21 normal brain tissues was measured by qPCR. The prognostic value of MRCCAT1 was investigated by Kaplan-Meier survival analysis. Read More

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December 2018

Low expression of miR-1231 in patients with glioma and its prognostic significance.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8399-8405

Department of Neurosurgery, Shenzhen People's Hospital, The Second Clinical Medical College of  Jinan University, Shenzhen, Guangdong, China.

Objective: MiR-1231 has been reported to be down-regulated in glioma tissues and to act as a negative regulator in glioma progression. However, the clinical significance of miR-1231 remains unclear. In this study, we aimed to further demonstrate the expression pattern and prognostic value of miR-1231 in glioma patients. Read More

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December 2018
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