7,910 results match your criteria SAGE Open [Journal]


Signalling molecules responsive to ozone-induced oxidative stress in Salvia officinalis.

Sci Total Environ 2018 Dec 2;657:568-576. Epub 2018 Dec 2.

Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, Pisa 56124, Italy; CIRSEC, Centre for Climatic Change Impact, University of Pisa, Via del Borghetto 80, Pisa 56124, Italy; Nutrafood Research Center, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.

Tropospheric ozone (O) is the most important gaseous pollutant and induces a mass of negative impacts on vegetation at functional and genic levels. The aim of the present study was to investigate the role of reactive oxygen species and signalling molecules in sage plants exposed to O (200 ppb, 5 h). Ozone exposure induced only a transient oxidative burst, as confirmed by the rapid peak of anion superoxide during the first hours of exposure (+16% compared to controls). Read More

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December 2018

Design and methodology of a cluster-randomized trial in early care and education centers to meet physical activity guidelines: Sustainability via Active Garden Education (SAGE).

Contemp Clin Trials 2018 Dec 11. Epub 2018 Dec 11.

Center for Health Promotion and Disease Prevention, College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, United States.

Strategies are needed to help early care and education centers (ECEC) comply with policies to meet daily physical activity and fruit and vegetable guidelines for young children. This manuscript describes the design and methodology of Sustainability via Active Garden Education (SAGE), a 12-session cluster-randomized controlled crossover design trial using community-based participatory research (CBPR) to test a garden-based ECEC physical activity and fruit and vegetables promotion intervention for young children aged 3-5 years in 20 sites. The SAGE curriculum uses the plant lifecycle as a metaphor for human development. Read More

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December 2018

Using the behavior change wheel to identify barriers to and potential solutions for primary care clinical guideline use in four provinces in South Africa.

BMC Health Serv Res 2018 Dec 14;18(1):965. Epub 2018 Dec 14.

Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177, Stockholm, Sweden.

Background: Clinical practice guidelines risk having little impact on healthcare if not effectively implemented. Theory informed, targeted implementation may maximise their impact. Our study explored barriers to and facilitators of guideline implementation and use by South African primary care nurses and allied healthcare workers in four provinces in South Africa. Read More

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December 2018

Ideal Cardiovascular Health and Cognitive Test Performance: Testing a Modified Index of Life's Simple 7 Among Older Chinese Adults.

Front Public Health 2018 28;6:352. Epub 2018 Nov 28.

Department of Anthropology, Dartmouth College, Hanover, NH, United States.

Evidence suggests that cognitive decline in older adults is influenced by cardiovascular health (CVH), with metabolic and vascular mechanisms hypothesized to underlie the etiology of cognitive impairment. Research in high-income nations suggests that improved CVH is linked with decreased cognitive impairment risk, but it is unclear if this pattern is evident in low-income countries. Nationally-representative data collected in China were drawn from the World Health Organization's Study on global AGing and adult health Wave 1 (2007-2010; = 11,295). Read More

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November 2018
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Comprehensive functional genomic resource and integrative model for the human brain.

Science 2018 Dec;362(6420)

Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.

Despite progress in defining genetic risk for psychiatric disorders, their molecular mechanisms remain elusive. Addressing this, the PsychENCODE Consortium has generated a comprehensive online resource for the adult brain across 1866 individuals. The PsychENCODE resource contains ~79,000 brain-active enhancers, sets of Hi-C linkages, and topologically associating domains; single-cell expression profiles for many cell types; expression quantitative-trait loci (QTLs); and further QTLs associated with chromatin, splicing, and cell-type proportions. Read More

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December 2018
1 Read

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.

Science 2018 Dec;362(6420)

Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA.

Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments of transcriptomic organization in diseased brains are limited. In this work, we integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, and bipolar disorder, as well as controls. Read More

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December 2018
2 Reads

Chronic Musculoskeletal Pain, Self-Reported Health and Quality of Life among Older Populations in South Africa and Uganda.

Int J Environ Res Public Health 2018 Dec 10;15(12). Epub 2018 Dec 10.

School of Medicine and Health Management, Tongji medical college, Huazhong University of Science and Technology, Wuhan 430030, China.

Chronic musculoskeletal pain (CMP) is a serious health concern especially among the elderly population and has significant bearing on health and quality of life. Not much is known about the relationship between chronic pain with self-reported health and quality of life among older populations in low-resource settings. Based on sub-national data from South Africa and Uganda, the present study aimed to explore whether the older population living with CMP report health and quality of life differently compared to those with no CMP complaints. Read More

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December 2018

Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets.

PLoS One 2018 13;13(12):e0209112. Epub 2018 Dec 13.

Department of Medicine & Epidemiology, School of Veterinary Medicine University of California Davis, Davis, California, United States of America.

Introduction: Golden retrievers are over-represented in cases of taurine-deficient dilated cardiomyopathy and recently a surge in cases has prompted further investigation.

Objective: To describe the clinical, dietary, and echocardiographic features in golden retrievers diagnosed with taurine deficiency and dilated cardiomyopathy, and to determine specific dietary associations. A second aim was to determine the whole blood taurine concentrations in a representative sample of healthy golden retrievers. Read More

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December 2018

Novel developments in .

Ther Adv Psychopharmacol 2018 Dec 19;8(12):329-331. Epub 2018 Nov 19.

Editor-in-Chief, Therapeutic Advances in Psychopharmacology, Maudsley Hospital, London, UK.

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December 2018

Cognitive self-assessment scales in surgical settings: Acceptability and feasibility.

Best Pract Res Clin Anaesthesiol 2018 Sep - Dec;32(3-4):303-309. Epub 2018 Aug 9.

The Ohio State University, Wexner Medical Center, Department of Anesthesiology, Columbus, OH, USA; The Ohio State University, Wexner Medical Center, Department of Neurological Surgery, Columbus, OH, USA.

Pre-existing cognitive impairment is associated with poor surgical outcomes, long hospital stays, and increased morbidity and mortality. This necessitates the use of screening tools to evaluate preoperative cognitive status in elderly surgical patients. Given the growing population of older adults and increased prevalence of cognitive impairment, it is necessary to investigate whether staff-administered or self-administered cognitive screening examinations provide more sensitive information about pre-existing (preoperative) cognitive status. Read More

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Venous leiomyosarcoma arising from the radiocephalic vein.

J Med Vasc 2018 Dec 31;43(6):369-370. Epub 2018 Oct 31.

Department of Pathology, University Hospital Grenoble, 38043 Grenoble, France.

Vascular leiomyosarcoma is a very rare soft tissue neoplasma. We are reporting a vascular leiomyosarcoma case arising from an unusual site: the radiocephalic vein. Despite a poor prognosis, after surgery and radiotherapy, the patient was alive without signs of recurrence two years later. Read More

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December 2018

Cytotoxic Tolerance of Healthy and Cancerous Bone Cells to Anti-microbial Phenolic Compounds Depend on Culture Conditions.

Appl Biochem Biotechnol 2018 Dec 10. Epub 2018 Dec 10.

Department of Bioengineering, Izmir Institute of Technology, 35430, Urla, Izmir, Turkey.

Carnosol and carnosic acid are polyphenolic compounds found in rosemary and sage with known anti-oxidant, anti-inflammatory, and anti-microbial properties. Here, we addressed the potential use of carnosol and carnosic acid for in vitro bone tissue engineering applications, specifically depending on their cytotoxic effects on bone marrow stromal and stem cells, and osteosarcoma cells in monolayer and 3D cultures. Carnosol and carnosic acid displayed a bacteriostatic effect on Gram-positive bacteria, especially on S. Read More

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December 2018

[Remarks on the possibility of the introduction of fractionated dose of the inactivated poliomyelitis vaccine in the Latin American Child Immunization Schedule].

Rev Chilena Infectol 2018 Aug;35(4):395-402

Sociedad Latinoamericana de Infectología Pediátrica, Mexico.

As last notified case of poliomyelitis due to wild poliovirus type 2 was 1999, in 2012, the Strategic Advisory Group of Experts on Immunization (SAGE) of the World Health Organization (WHO) recommended the withdrawal of the type 2 component of oral polio vaccine (OPV) and the introduction of bivalent OPV (bOPV) in all countries by 2016. WHO recommended also that the withdrawal should be preceded by the introduction of at least one dose of inactivated poliovirus vaccine (IPV) in routine immunization schedules. The introduction of IPV prior to the change of the bOPV in 2016 to trivalent OPV (tOPV) was based on the concept of ensuring that a substantial proportion of the population would be protected against type 2 polio after the removal of the type 2 OPV. Read More

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August 2018
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A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression.

Front Endocrinol (Lausanne) 2018 23;9:703. Epub 2018 Nov 23.

Neuroscience Department, Tufts University School of Medicine, Boston, MA, United States.

Preclinical testing of treatments for postpartum depression (PPD) has been limited due to the lack of available animal models of such a complex disorder. To address this limitation, our laboratory has generated unique preclinical mouse models that exhibit abnormal postpartum behaviors. Mice with a loss or reduction in the expression of the GABA receptor (GABAR) δ subunit ( or , respectively) and mice that lack the K/Cl co-transporter, KCC2, specifically in corticotropin-releasing hormone (CRH) neurons (KCC2/Crh mice) exhibit depression-like behaviors restricted to the postpartum period and deficits in maternal care, which serve as useful tools for testing novel therapeutic compounds. Read More

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November 2018

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.

Proc Natl Acad Sci U S A 2018 Dec 10. Epub 2018 Dec 10.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115;

T cell-mediated immune responses are compromised in aged individuals, leading to increased morbidity and reduced response to vaccination. While cellular metabolism tightly regulates T cell activation and function, metabolic reprogramming in aged T cells has not been thoroughly studied. Here, we report a systematic analysis of metabolism during young versus aged naïve T cell activation. Read More

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December 2018

The Role of Government in Precision Medicine, Precision Public Health and the Intersection with Healthy Living.

Prog Cardiovasc Dis 2018 Dec 7. Epub 2018 Dec 7.

Institute for Precision Cardiovascular Medicine, American Heart Association, Dallas, TX, United States of America; Department of Medicine, University of Minnesota, Minneapolis, MN, United States of America; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.

This paper focuses on the significant role of government in promoting precision medicine and public health and the potential intersection with healthy living (HL) and population health. Recent research has highlighted the interplay between genes, environments and different exposures individuals and populations experience over a lifetime. These interactions between longitudinal behaviors, epigenetics, and expression of the human genome have the potential to transform health and well-being, even within a single generation. Read More

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December 2018

The association between diabetes and cataract among 42,469 community-dwelling adults in six low- and middle-income countries.

Diabetes Res Clin Pract 2018 Dec 6;147:102-110. Epub 2018 Dec 6.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain.

Background: Cataract is a major cause of visual impairment in people with diabetes, yet a paucity of data is available in low- and middle-income countries (LMICs) on this comorbidity. Thus we assessed the association between diabetes and cataract in 6 LMICs.

Methods: Cross-sectional, community-based data from the Study on Global Ageing and Adult Health (SAGE) was analyzed (n = 42,469 aged ≥18 years). Read More

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December 2018

Modelling to inform prophylaxis regimens to prevent human rabies.

Vaccine 2018 Dec 7. Epub 2018 Dec 7.

Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK. Electronic address:

Background: The Strategic Advisory Group of Experts (SAGE) Working Group on rabies vaccines and immunoglobulins was established in 2016 to develop practical and feasible recommendations for prevention of human rabies. To support the SAGE agenda we developed models to compare the relative costs and potential benefits of rabies prevention strategies.

Methods: We examined Post-Exposure Prophylaxis (PEP) regimens, protocols for administration of Rabies Immunoglobulin (RIG) and inclusion of rabies Pre-Exposure Prophylaxis (PrEP) within the Expanded Programme on Immunization (EPI). Read More

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December 2018
2 Reads

The impact of transmission dynamics of rabies control: Systematic review.

Vaccine 2018 Dec 5. Epub 2018 Dec 5.

Health Technology Assessment Postgraduate Program, Mahidol University, 447 Sri-Ayuthaya Road, Phaya Thai, Ratchathewi, Bangkok 10400, Thailand; Department of Epidemiology, Faculty of Public Health, Mahidol University, 420/1 Ratchawithi Road, Phaya Thai, Ratchathewi, Bangkok 10400, Thailand. Electronic address:

The public health and economic burden of rabies has led to major intersectoral initiatives worldwide to reduce its burden. Over the last decade, the impact of rabies prevention and control programmes in real-world settings has become increasingly evident, especially in countries where most rabies exposures and deaths occur, but they have yet to successfully eradicate rabies due to limited access to health care services. We aimed to systematically review published transmission dynamic modelling studies of rabies in both humans and dogs with a focus on studies which estimated the epidemiological and economic impact of different preventive measures. Read More

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December 2018

Patient and treatment pathways for toxoplasmosis in the United States: data analysis of the Vizient Health Systems Data from 2011 to 2017.

Pathog Glob Health 2018 Dec 10:1-10. Epub 2018 Dec 10.

e Department of Medical Affairs , Vyera Pharmaceuticals , New York , NY , USA.

Toxoplasmosis causes substantial morbidity and mortality in the United States (US). Clinical manifestations to toxoplasmosis vary and there is limited information on incidence or treatment patterns in the US. Treatment pathways for pyrimethamine-based regimens and trimethoprim-sulfamethoxazole (TMP-SMX) for toxoplasmosis hospitalizations were investigated using the Vizient Health Systems inpatient and outpatient data. Read More

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December 2018

Reproductive heat tolerance in a Mojave Desert annual plant, Trianthema portulacastrum.

Am J Bot 2018 Dec 3. Epub 2018 Dec 3.

Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, ON, M5S 3B2, Canada.

Premise Of The Study: Reproduction in many crop species is impaired above 30° to 35°C; however, the sensitivity of reproduction in the natural flora remains uncertain. Studies focusing on the effect of high temperature on plant reproduction in wild species are necessary to improve our understanding of how rising global temperatures will impact global plant reproductive success and may ultimately inform models of plant distribution in the future. Additionally, these studies may highlight candidates for thermotolerance that could be further explored for crop improvement. Read More

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December 2018
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Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.

Exp Mol Pathol 2018 Nov 30;106:78-88. Epub 2018 Nov 30.

Departments of Pathology, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-Ku, Sapporo 060-8556, Japan; CREST, Japan Science and Technology Agency, Tokyo 102-0076, Japan. Electronic address:

Uterine endometrial carcinoma is one of the common cancers in females. Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) are a small subpopulation of cancer cells that are tumorigenic and are resistant to treatments, thus they are focused as treatment targets. However, the heterogeneity of CSCs/CICs is still elusive, and we therefore analyzed CSCs/CICs at the clonal level. Read More

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November 2018

The dynamical interplay between a megadalton peptide nanocage and solutes probed by microsecond atomistic MD; implications for design.

Phys Chem Chem Phys 2018 Dec 5. Epub 2018 Dec 5.

School of Biochemistry, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK. and BrisSynBio, Life Sciences Building, Tyndall Avenue, Bristol, BS8 1TQ, UK.

Understanding the assembly and dynamics of protein-based supramolecular capsids and cages is of fundamental importance and could lead to applications in synthetic biology and biotechnology. Here we present long and large atomistic molecular dynamics simulations of de novo designed self-assembling protein nanocages (SAGEs) in aqueous media. Microsecond simulations, comprised of ≈42 million atoms for three pre-formed SAGEs of different charges, in the presence of solutes and solvent have been completed. Read More

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December 2018
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Quantification of α-Thujone and Its Metabolites in Human Urine after Consumption of a Sage Infusion Using Stable Isotope Dilution Assays.

Toxins (Basel) 2018 Dec 3;10(12). Epub 2018 Dec 3.

Technical University of Munich, Chair of Analytical Food Chemistry, Maximus-von-Imhof-Forum 2, 85354 Freising, Germany.

The metabolism of the monoterpene α-thujone was investigated in humans after consumption of sage tea, by analyses of its metabolites 2-hydroxythujone, 4-hydroxythujone, and 7-hydroxythujone in urine. For the quantitation of α-thujone and its metabolites, stable isotope dilution assays were developed. Using ₆-α-thujone as internal standard, we quantified α-thujone by solid phase microextraction GC-MS and the hydroxythujones with ₆-2-hydroxythujone, ₆-4-hydroxythujone, and ₆-7-hydroxythujone after glucuronide/sulfate deconjugation by LC-MS/MS in urine. Read More

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December 2018

, and Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymes.

Molecules 2018 Dec 1;23(12). Epub 2018 Dec 1.

QOPNA & LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

Vahl., A. Gray, and L. Read More

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December 2018

Modeling atmospheric volatile organic compound concentrations resulting from a deepwater oil well blowout - Mitigation by subsea dispersant injection.

Mar Pollut Bull 2018 Nov 14;136:152-163. Epub 2018 Sep 14.

RPS, Houston Texas US now at Lehigh Hanson. Inc., Irving, TX, USA.

The atmospheric concentrations of volatile organic compounds (VOCs) generated by surface slicks during an oil spill have not been extensively studied. We modeled oil transport and fate, air emissions, and atmospheric dispersion of VOCs from a hypothetical deepwater well blowout in De Soto Canyon of the Gulf of Mexico assuming no intervention and use of SubSea Dispersant Injection (SSDI) at the source during three week-long periods representing different atmospheric mixing conditions. Spatially varying time histories of atmospheric VOCs within ~2 km from the release site were estimated. Read More

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November 2018

Gender differences in the association between migration and cognitive function among older adults in China and India.

Arch Gerontol Geriatr 2018 Nov 22;81:31-38. Epub 2018 Nov 22.

New York University Rory Meyers College of Nursing, New York, NY, USA.

Objective: This study aims to examine gender differences in the association between migration and cognitive function among adults in China and India.

Methods: Data from the World Health Organization Study on global AGEing and adult health (SAGE) study were used that included adults aged 50 + from China (N = 12,937) and India (N = 6244). Migration status included: urban residents, rural residents, urban-to-urban, rural-to-urban, rural-to-rural, and urban-to-rural migrants. Read More

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November 2018
2 Reads

Chromosome Doubling-Enhanced Biomass and Dihydrotanshinone I Production in Salvia miltiorrhiza, A Traditional Chinese Medicinal Plant.

Molecules 2018 Nov 27;23(12). Epub 2018 Nov 27.

Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.

The root of Chinese sage ( Bunge) was regarded as top-grade Chinese medicine two thousand years ago, according to . The aim of this study is to develop an easy and reliable means for obtaining tetraploids (4x plants) via thidiazuron-induced direct organogenesis in the presence of colchicine. The resulting 4x plants showed significantly enhanced agronomic traits, including the size of stomata, leaflet, pollen, and seed as well as shoot length, root diameter, number of leaves, and fresh weight of plant. Read More

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November 2018

Chilaiditi's sign, a cause of pseudo-pneumoperitoneum: A case report.

SAGE Open Med Case Rep 2018 19;6:2050313X18812213. Epub 2018 Nov 19.

Hospital Segamat, Segamat, Malaysia.

The differentiation between a pseudo-pneumoperitoneum and true pneumoperitoneum on an initial chest radiograph is challenging but essential to clinical practice. The former is managed conservatively whereas the latter may require surgical intervention. Chilaiditi's sign describes a rare incidental radiological finding of gas filled bowel interpositioned between the right hemi-diaphragm and the liver, which is visible on a plain abdominal or chest radiograph. Read More

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November 2018
8 Reads

Unique Biology and Single-Channel Properties of GluN2A- and GluN2C-Containing Triheteromeric N-Methyl-D-Aspartate Receptors.

J Exp Neurosci 2018 19;12:1179069518810423. Epub 2018 Nov 19.

Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA.

Triheteromeric N-methyl-D-aspartate receptors (NMDARs) are assemblies of two different types of GluN2 subunits that endow receptors with properties distinct from their diheteromeric counterparts. Previous studies show an abundance of triheteromeric NMDARs across the central nervous system (CNS), making them an important receptor population to investigate and potential drug target. A recent study by Bhattacharya et al. Read More

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November 2018

Discrepancies Between FDA-Required Labeling and Evidence that Payers Cite in Drug Coverage Policies.

J Manag Care Spec Pharm 2018 Dec;24(12):1240-1246

1 The Center for the Evaluation of Value and Risk in Health, Tufts Medical Center, Boston, Massachusetts.

Background: FDA-required labeling summarizes certain data that the FDA relies on in its drug approval process. However, when determining coverage of specialty drugs, health care payers may consider dissimilar evidence.

Objective: To compare evidence cited by the largest U. Read More

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December 2018
3 Reads

Ionic liquids as stationary phases for gas chromatography-Unusual selectivity of ionic liquids with a phosphonium cation and different anions in the flavor, fragrance and essential oil analyses.

J Chromatogr A 2018 Nov 19. Epub 2018 Nov 19.

Laboratory of Pharmaceutical Biology and Food Chemistry, Dipartimento di Scienza e Tecnologia del Farmaco, Via Pietro Giuria 9, I-10125 Torino, Italy. Electronic address:

Room-temperature ionic liquids (ILs) have been shown to be successful as stationary phases (SPs) for gas chromatography in several fields of applications because of their unique and tunable selectivity, low vapor pressure and volatility, high thermal stability (over 300 °C), and good chromatographic properties. This study has been focused on two ILs based on a phosphonium cation (trihexyl(tetradecyl)phosphonium, P) combined with different anions, previously shown to be suitable as gas chromatography (GC) SPs. In particular, trihexyl(tetradecyl)phosphonium bis[(trifluoromethyl)sulfonyl]imide ([P] [NTf]) and trihexyl(tetradecyl)phosphonium chloride ([P] [Cl]) were investigated, as the Abraham linear solvation energy relationship has shown their ability to interact with the solute(s) when tested with a set of 26-34 probe analytes. Read More

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November 2018

Evaluating new rabies post-exposure prophylaxis (PEP) regimens or vaccines.

Vaccine 2018 Nov 21. Epub 2018 Nov 21.

Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States. Electronic address:

The development of human rabies vaccines has evolved dramatically from the first crude nerve tissue vaccine produced then administered in the presence of Louis Pasteur in 1885. New cell culture technology has enabled highly potent and well-tolerated rabies vaccines to be produced that have reduced the volume and number of doses required to save human lives after exposure. However, these highly potent vaccines are still unaffordable to many patients living at risk of exposure on a daily basis. Read More

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November 2018

Observational studies of non-specific effects of Diphtheria-Tetanus-Pertussis vaccines in low-income countries: Assessing the potential impact of study characteristics, bias and confounding through meta-regression.

Vaccine 2019 Jan 22;37(1):34-40. Epub 2018 Nov 22.

GSK, Avenue Fleming 20, B-1300 Wavre, Belgium.

Introduction: It has been suggested that some vaccines have effects beyond protection against the diseases they target, called non-specific effects (NSEs). In 2016, a systematic review by Higgins et al., commissioned by the WHO Strategic Advisory Group of Experts (SAGE) on immunization, estimated the relative risk (RR) of all-cause mortality after whole-cell Diphtheria-Tetanus-Pertussis (DTwP) vaccination to be 1. Read More

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January 2019
1 Read

Intravenous single administration of amiodarone and breastfeeding.

Fundam Clin Pharmacol 2018 Nov 24. Epub 2018 Nov 24.

Centre Hospitalier Régional Universitaire de Nancy, Laboratoire de Pharmacologie Clinique et de Toxicologie, Nancy, France.

Amiodarone treatment is contraindicated during breastfeeding. As the regional pharmacovigilance center, we were contacted for information relative to the possibility of breastfeeding after single intravenous administration of 450 mg amiodarone to a breastfeeding woman. A monitoring of amiodarone concentration in plasma and milk was performed in the mother. Read More

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November 2018
1 Read

The humanistic burden of postpartum depression: a systematic literature review.

Curr Med Res Opin 2018 Nov 23:1-31. Epub 2018 Nov 23.

b Sage Therapeutics, Inc . , Cambridge , MA.

Objective: Postpartum depression (PPD) is the most common medical complication of childbirth. PPD can be disabling, with potential negative effects on maternal health-related quality of life (HRQoL) as well as on children and partners. The objective of this study was to systematically review and summarize recently published literature describing the humanistic burden of PPD on affected women, their children, and partners. Read More

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November 2018
2 Reads

Structural network disruption markers explain disability in multiple sclerosis.

J Neurol Neurosurg Psychiatry 2018 Nov 22. Epub 2018 Nov 22.

Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK.

Objective: To evaluate whether structural brain network metrics correlate better with clinical impairment and information processing speed in multiple sclerosis (MS) beyond atrophy measures and white matter lesions.

Methods: This cross-sectional study included 51 healthy controls and 122 patients comprising 58 relapsing-remitting, 28 primary progressive and 36 secondary progressive. Structural brain networks were reconstructed from diffusion-weighted MRIs and standard metrics reflecting network density, efficiency and clustering coefficient were derived and compared between subjects' groups. Read More

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November 2018
1 Read
6.807 Impact Factor

Heavy metals in spices commonly consumed in Republic of Korea.

Food Addit Contam Part B Surveill 2018 Nov 22:1-7. Epub 2018 Nov 22.

a Center for Food & Drug Analysis , Busan Regional Korea Food and Drug Administration , Busan , Republic of Korea.

Levels of lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg) were evaluated in 359 samples of commonly consumed spices (cinnamon, parsley, basil, oregano, coriander seed, nutmeg, cumin, bay leaf, fenugreek, rosemary, thyme, fennel, sage, clove, marjoram, tarragon, caraway, dill seed, pepper, and turmeric) from the market in the Republic of Korea. The content of Pb, Cd, and As was assessed by acid wet digestion using a microwave oven and inductively coupled plasma mass spectrometry (ICP-MS). The content of Hg was analysed using a direct mercury analyzer (DMA). Read More

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November 2018
2 Reads

Social engagement and survival in people aged 50 years and over living with HIV and without HIV in Uganda: a prospective cohort study.

Afr J AIDS Res 2018 Nov 23:1-8. Epub 2018 Nov 23.

a Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine , Uganda Research Unit on AIDS , Entebbe , Uganda.

This study examined the association between social engagement and survival in people with or without HIV aged 50 years and over in Uganda. We analysed two waves of a survey from two sites in Uganda to assess predictors of mortality between waves. The first wave was conducted between 2009 and 2010 while the second wave was conducted between 2012 and 2013. Read More

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November 2018

Gendered "Long Arm" of Parental Education? Life Course Influences on Later Life Functional Limitations in India.

J Aging Health 2018 Nov 23:898264318812668. Epub 2018 Nov 23.

2 Case Western Reserve University, Cleveland, OH, USA.

Objective: We adopt a novel approach to mediation analysis to account for interrelated life course social processes that constitute later life health disparities. We examine gender-specific direct effect of parental education on functional limitations in later life.

Method: Based on the first wave (2007-2010; n = 7,150) of the Study on Global Ageing and Adult Health (SAGE), we estimate both (natural) direct and indirect effects of parental education on functional limitations in later life. Read More

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November 2018
1 Read

Flood Risk Perceptions and Insurance Choice: Do Decisions in the Floodplain Reflect Overoptimism?

Risk Anal 2018 Nov 20. Epub 2018 Nov 20.

In the presence of rare disasters, risk perceptions may not always align with actual risks. These perceptions can nevertheless influence an individual's willingness to mitigate risks through activities such as purchasing flood insurance. In a survey of Maryland floodplain residents, we find that stated risk perceptions predict voluntary flood insurance take-up, while perceptions themselves varied widely among surveyed residents, owing in large part to differences in past flood experience. Read More

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November 2018

Assessment of histopathology of wounds based on protein distribution detected by wound blotting.

SAGE Open Med 2018 14;6:2050312118812220. Epub 2018 Nov 14.

Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Shortening the duration of healing based on an accurate assessment is important in pressure ulcer management. This study focused on the peroxidase and alkaline phosphatase activity detected by wound blotting, a non-invasive method of collecting wound exudate, to establish a non-invasive and point-of-care assessment method for analyzing the histopathology of wounds using an animal model.

Methods: Wounds were created on the dorsal skin of rats. Read More

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November 2018
3 Reads

Use of immunohistochemical analysis of CK5/6, CK14, and CK34betaE12 in the differential diagnosis of solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia of the breast.

SAGE Open Med 2018 9;6:2050312118811542. Epub 2018 Nov 9.

Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.

Objectives: The aim of this study was to use immunohistochemistry to differentiate solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia (IPUDH). Three types of high-molecular-weight cytokeratins (CKs) - CK5/6, CK14, and CK34betaE12 - were targeted.

Methods: We studied 17 patients with solid papillary carcinoma in situ and 18 patients with IPUDH diagnosed by at least two pathologists. Read More

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November 2018

Anti-proliferative and anti-inflammatory activities of the sea cucumber aqueous extract.

SAGE Open Med 2018 2;6:2050312118809541. Epub 2018 Nov 2.

Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.

Objective: Sea cucumbers are considered among the most important functional foods. Following bioassay guided fractionation, we assessed the anti-proliferative and anti-inflammatory activities of () extracts.

Methods: Sea cucumber ethanolic extract and the partially purified aqueous fractions were assessed for their anti-proliferative activities. Read More

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November 2018
6 Reads

End-user involvement in developing and field testing an online contraceptive decision aid.

SAGE Open Med 2018 2;6:2050312118809462. Epub 2018 Nov 2.

Department of General Practice, Student Health Service, University of Amsterdam, Amsterdam, The Netherlands.

Objectives: Decision aids in the field of healthcare contribute to informed decision making. To increase the usefulness and effectiveness of decision aids, it is important to involve end-users in the development of these tools. This article reports on the development of an online contraceptive decision aid. Read More

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November 2018

Immunology beliefs as a factor in vaccine opposition among complementary and alternative medical providers.

SAGE Open Med 2018 31;6:2050312118807625. Epub 2018 Oct 31.

College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.

Objectives: Parental pediatric vaccine decisions are influenced by parents' health provider networks. Complementary and alternative medical providers may be key influences in the networks of those parents who do not vaccinate their children.

Methods: From March to July 2013, we conducted semi-structured interviews of Oregon complementary and alternative medical providers ( = 36) in five disciplines likely to treat parents or children, or both, and whose practitioners are known to express opinions about vaccines and vaccination. Read More

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October 2018
4 Reads

Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence.

BMC Genomics 2018 Nov 20;19(1):826. Epub 2018 Nov 20.

Center for Pharmacogenomics, Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, 1004 Biomedical Research Tower, 460 W 12th Avenue, Columbus, OH, USA.

Background: The CHRNA5/A3/B4 gene locus is associated with nicotine dependence and other smoking related disorders. While the non-synonymous CHRNA5 variant rs16969968 appears to be the main risk factor, linkage disequilibrium (LD) bins in the gene cluster carry frequent variants that regulate expression. Pairwise LD and haplotype analyses had identified at least three haplotype tagging SNPs including rs16969968 as main genetic risk factors. Read More

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November 2018
1 Read

Fungal spores as a source of sodium salt particles in the Amazon basin.

Nat Commun 2018 11 19;9(1):4793. Epub 2018 Nov 19.

Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.

In the Amazon basin, particles containing mixed sodium salts are routinely observed and are attributed to marine aerosols transported from the Atlantic Ocean. Using chemical imaging analysis, we show that, during the wet season, fungal spores emitted by the forest biosphere contribute at least 30% (by number) to sodium salt particles in the central Amazon basin. Hydration experiments indicate that sodium content in fungal spores governs their growth factors. Read More

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November 2018
13 Reads

Inhaled nitric oxide dependency at the end of double-lung transplantation: A boosted propensity score cohort analysis.

Transpl Int 2018 Nov 17. Epub 2018 Nov 17.

Department of Anesthesiology, Hôpital Foch, 92150 Suresnes, France and Université Versailles-Saint-Quentin-en-Yvelines,, 78000, Versailles, France.

Objective: Inhaled nitric oxide (iNO) is usually used during lung transplantation despite controversial postoperative benefits. Our group chose to administer iNO systematically during the procedure and stop at end of surgery. This study aims to describe the features of patients who cannot be weaned from iNO, the reasons for this and its impact on postoperative outcomes. Read More

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November 2018
8 Reads