16,074 results match your criteria Rubella


A microneedle patch for measles and rubella vaccination: a game changer for achieving elimination.

Curr Opin Virol 2020 Jul 1;41:68-76. Epub 2020 Jul 1.

Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA.

While morbidity and mortality associated with measles and rubella (MR) have dramatically decreased, there are still >100000 estimated deaths due to measles and an estimated 100000 infants born with congenital rubella syndrome annually. Given highly effective MR vaccines, the primary barrier to global elimination of these diseases is low vaccination coverage, especially among the most underserved populations in resource-limited settings. In contrast to conventional MR vaccination by hypodermic injection, microneedle patches are being developed to enable MR vaccination by minimally trained personnel. Read More

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http://dx.doi.org/10.1016/j.coviro.2020.05.005DOI Listing

Longitudinal Profiling of the Vaccination Coverage in Brazil Reveals a Recent Change in the Patterns Hallmarked by Differential Reduction Across Regions.

Int J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Curso de Medicina, Faculdade de Tecnologia e Ciências (UniFTC), Salvador, Bahia, Brazil; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil; Multinational Organization Network Sponsoring Translational and Epidemiological Research(MONSTER), Salvador, Bahia, Brasil.

Objective: Vaccination coverage is decreasing worldwide, favoring potential reemergence of vaccine-preventable disease. Here, we performed a longitudinal characterization of the vaccination coverage in Brazil and compared the profiles between the distinct regions in the country to test whether there has been a substantial change over the last five years.

Methods: We retrieved de-identified data publicly available from the repository of the Brazilian Ministry of Health, comprising detailed information on vaccination coverage, in all age groups, between 1994 and 2019. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326384PMC

Seroprevalence of Measles, Rubella, Tetanus, and Diphtheria Antibodies among Children in Haiti, 2017.

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia.

In Haiti, measles, rubella, and maternal and neonatal tetanus have been eliminated, but a diphtheria outbreak is ongoing as of 2019. We conducted a national representative, household-based, two-stage cluster survey among children aged 5-7 years in 2017 to assess progress toward maintenance of control and elimination of selected vaccine-preventable diseases (VPDs). We stratified Haiti into west region (west department, including the capital city) and non-west region (all other departments). Read More

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http://dx.doi.org/10.4269/ajtmh.20-0112DOI Listing

The Practice Guideline for Vaccinating Korean Patients with Autoimmune Inflammatory Rheumatic Disease.

Infect Chemother 2020 Jun;52(2):252-280

Department of Rheumatology, Chonnam National University Medical School & Hospital, Gwangju, Korea.

To develop a clinical practice guideline for vaccination in patients with autoimmune inflammatory rheumatic disease (AIIRD), the Korean College of Rheumatology and the Korean Society of Infectious Diseases developed a clinical practice guideline according to the clinical practice guideline development manual. Since vaccination is unlikely to cause AIIRD or worsen disease activities, required vaccinations are recommended. Once patients are diagnosed with AIIRD, treatment strategies should be established and, at the same time, monitor their vaccination history. Read More

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http://dx.doi.org/10.3947/ic.2020.52.2.252DOI Listing

Prolonged maternal shedding and maternal-fetal transmission of measles virus.

Clin Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Institut Pasteur, Biology of Infection Unit, Paris, France.

Prolonged measles virus detection in maternal saliva and blood was evidenced in 6 pregnant women. Maternal-fetal transmission was evidenced in 2/4 infants who were asymptomatic at birth, 21-24 weeks after maternal infection. Whereas peripartum congenital measles is severe, asymptomatic measles virus vertical transmission can occur earlier in pregnancy. Read More

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http://dx.doi.org/10.1093/cid/ciaa915DOI Listing

[Re-emerging Rubella Epidemic and Public Health Measures in Japan].

Yakugaku Zasshi 2020 ;140(7):901-904

Infectious Disease Surveillance Center, National Institute of Infectious Diseases.

Although rubella is usually a mild, febrile illness, and up to 50% of rubella infections are asymptomatic, congenital rubella syndrome (CRS) can occur in the developing fetus of a pregnant woman infected with rubella virus (RV) in early pregnancy. After a rubella outbreak from early 2012 to late 2013 in Japan, another outbreak re-emerged from mid-2018 in the Tokyo metropolitan area and other large cities. In 2018, and up to epidemiological week (EW) 25 in 2019, more than 4000 rubella cases had been reported. Read More

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http://dx.doi.org/10.1248/yakushi.19-00255-3DOI Listing
January 2020

A review of intralesional wart therapy.

Dermatol Online J 2020 Mar 15;26(3). Epub 2020 Mar 15.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.

Background: New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and candida antigen but there have been limited studies to compare their efficacies.

Objective: The purpose of this systematic review is to compare the efficacy and safety of injectable agents used for the treatment of warts.

Methods: A PubMed search included terms "intralesional wart therapy," "wart injection" and "verruca injection. Read More

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The Cost-Effectiveness of Universal Varicella Vaccination in Italy: A Model-Based Assessment of Vaccination Strategies.

Clinicoecon Outcomes Res 2020 8;12:273-283. Epub 2020 Jun 8.

Center for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, NJ, USA.

Background: In 2017, varicella vaccination became mandatory for all children in Italy, based on a two-dose schedule administered at 12-15 months of age and 5 to 6 years of age. Varicella vaccines are available in different formulations (as a single vaccine or as a combination vaccine together with measles, mumps, and rubella) and are made by multiple manufacturers with different effectiveness profiles. This study calculates the cost-effectiveness of a range of varicella vaccination strategies to identify the optimal strategy for Italy. Read More

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http://dx.doi.org/10.2147/CEOR.S229685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294569PMC

Evaluation of two (02) platforms for chemiluminescence-based detection of anti-rubella IgG antibodies in a sub-Saharan country, Côte d'Ivoire.

J Immunoassay Immunochem 2020 Jun 30:1-11. Epub 2020 Jun 30.

Department of Haematology and Immunology, University Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire.

The diagnosis of rubella is mainly made in pregnant women and the newborn by specific IgG and/or IgM detection. In addition to HAI and ELISA techniques, new immunoanalytical methods have been developed. This study aimed to evaluate two chemiluminescence platforms, Architect i2000SR and Maglumi 800 for rubella biological diagnosis in Côte d'Ivoire. Read More

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http://dx.doi.org/10.1080/15321819.2020.1786398DOI Listing

Prevalence of toxoplasmosis, rubella, cytomegalovirus, and herpes (TORCH) infections among women attending the antenatal care clinic, maternity hospital in Abha, Southwestern Saudi Arabia.

Saudi Med J 2020 Jul;41(7):757-762

Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia. E-mail.

Objectives: To investigate the presence of toxoplasmosis, rubella, cytomegalovirus, and herpes (TORCH) infections in women attending at the antenatal care clinic in Abha, Kingdom of Saudi Arabia (KSA). Methods: A total of 190 blood samples were collected from Abha maternity hospital in Aseer region, KSA, from February 2018 to May 2019 and screened with the TORCH panel (toxoplasmagondii [IgG/IgM], cytomegalovirus [CMV] [IgG/IgM], rubella [IgG/IgM], and herpes simplex type 1 and 2 [IgG/IgM]).

Results: The mean age was 31. Read More

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http://dx.doi.org/10.15537/smj.2020.7.25121DOI Listing
July 2020
0.554 Impact Factor

Effect of Maternal Rubella Virus Infection on Fetal Cardiac Function and Neural Development by Color Doppler Ultrasound (Cardiography) Information Technology.

Authors:
Haixia Liu Wei Shi

Neurosci Lett 2020 Jun 26:135209. Epub 2020 Jun 26.

Third department of Ultrasound, Cangzhou Central Hospital, Cangzhou City, 061001, Hebei Province, China. Electronic address:

This study was aimed to explore the effect of maternal rubella virus infection on fetal cardiac function and neural development by color Doppler ultrasound cardiogram based on computer information technology. 658 pregnant women who were treated in our hospital were selected as the research subject. The rubella virus IgM antibody test, prenatal color Doppler ultrasound cardiogram test, suspicious neonatal ultrasound test and follow-up were performed on them. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135209DOI Listing

Paediatrics in Theresienstadt ghetto.

Cent Eur J Public Health 2020 Jun;28(2):155-160

Faculty of Education, Comenius University, Bratislava, Slovak Republic.

The main objective of this study is to describe the most common childhood diseases occurring in the Theresienstadt ghetto during the Second World War as well as applied anti-epidemic measures. A partial objective is to describe medical and nursing care of sick child prisoners. The data was obtained by the method of synthesis of primary and secondary data with the highest importance after adequate external source criticism using selected monographs, memoirs, survivor diaries, Orders of the day by the Council of the Elders and Reports of the Jewish self-government of the Theresienstadt ghetto from 1941 to 1945, the Archives of the Jewish Museum in Prague, the Ghetto Museum, the Museum of the History of Polish Jews in Warsaw, Post Bellum online electronic collection of oral historical interviews, and witness accounts. Read More

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http://dx.doi.org/10.21101/cejph.a5557DOI Listing

Vaccination rates for Syrian population under temporary protection in Turkey.

Cent Eur J Public Health 2020 Jun;28(2):130-134

Directorate General of Public Health, Ministry of Health, Ankara, Turkey.

Objectives: The aim of this study was to gather information on demographic and health indicators, primarily vaccination status, of Syrians under temporary protection in five provinces of Turkey and to develop infrastructure for vaccination planning.

Methods: The population under study consists of 89,986 Syrian children, 0-4 years of age, residing in Ankara, Mersin, Gaziantep, Izmir, and Bursa. Initially, we planned to evaluate 2,339 children, although a total of 2,827 children were evaluated by the end of the study. Read More

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http://dx.doi.org/10.21101/cejph.a5543DOI Listing
June 2020
0.798 Impact Factor

Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.

Arch Dis Child 2020 Jun 25. Epub 2020 Jun 25.

Department of Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK.

Background: The epidemiology of congenital infections is ever changing, with a recent resurgence in syphilis infection rates seen in the UK. Identification of congenital infection is often delayed; early recognition and management of congenital infections is important. Testing modalities and investigations are often limited, leading to missed diagnostic opportunities. Read More

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http://dx.doi.org/10.1136/archdischild-2020-318841DOI Listing

Evaluation of vaccination coverage of measles-rubella campaign in Imphal East District, Manipur: A cross-sectional study.

Indian J Public Health 2020 Apr-Jun;64(2):173-177

PGT, Department of Community Medicine, Jawaharlal Nehru Institute of Medical Sciences, Imphal, Manipur, India.

Background: In India, the measles-rubella (MR) vaccination campaign was conducted with the purpose of vaccinating all children of 9 months-15 years of age with a single dose of MR vaccine. However, it encountered various challenges which may hamper with the coverage.

Objectives: This study was conducted to evaluate the recently conducted MR campaign in Manipur pertaining to its coverage and factors for not vaccinating. Read More

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http://dx.doi.org/10.4103/ijph.IJPH_361_19DOI Listing

Does Early Childhood Vaccination Protect Against COVID-19?

Front Mol Biosci 2020 5;7:120. Epub 2020 Jun 5.

Panevezys Faculty of Technology and Business, Kaunas Technology University (KTU), Panevezys, Lithuania.

The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Read More

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http://dx.doi.org/10.3389/fmolb.2020.00120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292051PMC

Molecular Epidemiology of B3 and D8 Measles Viruses through Hemagglutinin Phylogenetic History.

Int J Mol Sci 2020 Jun 22;21(12). Epub 2020 Jun 22.

Department of Biomedical Sciences for Health, University of Milan, via Carlo Pascal 36, 20133 Milan, Italy.

Of the 24 known measles genotypes, only D8 and B3 are responsible for outbreaks in the last years in Europe, Asia, and America. In this study the H gene of 92 strains circulating between 2015 and 2019 in Lombardy, Northern Italy, and 1273 H sequences available in GenBank were analyzed in order to evaluate the genetic variability and to assess the conservation of the immunodominant sites. Overall, in Lombardy we observed the presence of four different B3 and three different D8 clusters, each one of them including sequences derived from viruses found in both vaccinated and unvaccinated subjects. Read More

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http://dx.doi.org/10.3390/ijms21124435DOI Listing

The status of rubella IgG antibody titer between antenatal and postnatal among pregnant non-immune to rubella.

Hum Vaccin Immunother 2020 Jun 23:1-4. Epub 2020 Jun 23.

Reproductive Endocrine and Infertility Medicine Department, King Fahad Medical City , Riyadh, Saudi Arabia.

Background: The infection of rubella in pregnancy is worrisome due to the fact that it causes miscarriages, congenital defects, and Congenital Rubella Syndrome (CRS). The purpose of this study was to determine the status of Rubella IgG antibody levels both during the antenatal and postnatal periods among pregnant women nonimmune to rubella and the incidence of exposure to rubella in pregnancy.

Methods: This was a prospective cohort study that included 4770 pregnant, who attended the obstetric clinics and delivered in Women's Specialized Hospital, King Fahad Medical City, between January and December 2015. Read More

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http://dx.doi.org/10.1080/21645515.2020.1771077DOI Listing

Faster waning of the rubella specific immune response in young pregnant women immunized with MMR at 15 months.

Am J Reprod Immunol 2020 Jun 22:e13294. Epub 2020 Jun 22.

Department of Education and Research, Fooyin University Hospital, Pingtung, Taiwan.

Problem: Vaccination is the best protection against rubella and congenital rubella infection. Although a high rate of immunization coverage is achieved in Taiwan, it is unknown if the vaccine induced immunity persists from the age of vaccination to childbearing age.

Methods Of Study: A total of 5,988 prenatal rubella IgG test results of young pregnant women aged 19-23 years old from six hospitals during Jan. Read More

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http://dx.doi.org/10.1111/aji.13294DOI Listing

Can Users Search Trends Predict People Scares or Disease Breakout? An Examination of Infectious Skin Diseases in the United States.

Infect Dis (Auckl) 2020 8;13:1178633720928356. Epub 2020 Jun 8.

Jordanian Royal Medical Services, Amman, Jordan.

Background: In health and medicine, people heavily use the Internet to search for information about symptoms, diseases, and treatments. As such, the Internet information can simulate expert medical doctors, pharmacists, and other health care providers.

Aim: This article aims to evaluate a dataset of search terms to determine whether search queries and terms can be used to reliably predict skin disease breakouts. Read More

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http://dx.doi.org/10.1177/1178633720928356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285938PMC

Measles, mumps, rubella, and varicella-zoster virus serology and infections in solid organ transplant recipients during the first year post-transplantation.

Clin Infect Dis 2020 Jun 21. Epub 2020 Jun 21.

Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Mumps, measles, rubella, and varicella-zoster viruses (MMRV) may cause severe infections in seronegative adult solid organ transplant (SOT) recipients but can be prevented by vaccination. We aimed to determine MMRV serostatus in adult SOT recipients before and one-year post-transplantation as well as evidence of MMRV infections in a large, prospective cohort of SOT recipients.

Methods: A prospective study of 1182 adult SOT recipients included in the Management of Posttransplant Infections in Collaborating Hospitals (MATCH) cohort from 2011 to 2017 with a one-year follow-up. Read More

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http://dx.doi.org/10.1093/cid/ciaa824DOI Listing

Could an Unrelated Live Attenuated Vaccine Serve as a Preventive Measure To Dampen Septic Inflammation Associated with COVID-19 Infection?

mBio 2020 06 19;11(3). Epub 2020 Jun 19.

Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.

We propose the concept that administration of an unrelated live attenuated vaccine, such as MMR (measles, mumps, rubella), could serve as a preventive measure against the worst sequelae of coronavirus disease 2019 (COVID-19). There is mounting evidence that live attenuated vaccines provide nonspecific protection against lethal infections unrelated to the target pathogen of the vaccine by inducing "trained" nonspecific innate immune cells for improved host responses against subsequent infections. Mortality in COVID-19 cases is strongly associated with progressive lung inflammation and eventual sepsis. Read More

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http://dx.doi.org/10.1128/mBio.00907-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304316PMC

Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature.

Rev Bras Ginecol Obstet 2020 Jun 19. Epub 2020 Jun 19.

Departament of Gynecology and Obstetrics, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Objective:  The aim of the current review is to present a systematic evaluation of reported human placental findings in cases of zika virus (ZIKV) infection.

Data Sources:  We reviewed the EMBASE, PUBMED, and SCIELO databases until June 2019, without language restrictions.

Selection Of Studies:  The search terms AND were used. Read More

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http://dx.doi.org/10.1055/s-0040-1712126DOI Listing

Measles surveillance in Canada: 2018.

Can Commun Dis Rep 2020 Apr 2;46(4):77-83. Epub 2020 Apr 2.

Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.

Background: Measles has been eliminated in Canada since 1998. Every year, the Public Health Agency of Canada presents epidemiologic evidence to the Pan American Health Organization (PAHO) to verify that measles continues to be eliminated in Canada. The objectives of this article are to: provide an epidemiologic summary of measles activity reported in 2018 in Canada, and provide documented evidence to support the continued verification of measles elimination status in Canada. Read More

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http://dx.doi.org/10.14745/ccdr.v46i04a04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279125PMC

Progress Toward Rubella Elimination - Western Pacific Region, 2000-2019.

MMWR Morb Mortal Wkly Rep 2020 Jun 19;69(24):744-750. Epub 2020 Jun 19.

Rubella is the leading vaccine-preventable cause of birth defects. Rubella typically manifests as a mild febrile rash illness; however, infection during pregnancy, particularly during the first trimester, can result in miscarriage, fetal death, or a constellation of malformations known as congenital rubella syndrome (CRS), commonly including one or more visual, auditory, or cardiac defects (1). In 2012, the Regional Committee of the World Health Organization (WHO) Western Pacific Region (WPR)* committed to accelerate rubella control, and in 2017, resolved that all countries or areas (countries) in WPR should aim for rubella elimination as soon as possible (2,3). Read More

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http://dx.doi.org/10.15585/mmwr.mm6924a4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302473PMC

Measles virus and rinderpest virus divergence dated to the sixth century BCE.

Science 2020 06;368(6497):1367-1370

Epidemiology of Highly Pathogenic Microorganisms Project Group, Robert Koch Institute, Berlin, Germany.

Many infectious diseases are thought to have emerged in humans after the Neolithic revolution. Although it is broadly accepted that this also applies to measles, the exact date of emergence for this disease is controversial. We sequenced the genome of a 1912 measles virus and used selection-aware molecular clock modeling to determine the divergence date of measles virus and rinderpest virus. Read More

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http://dx.doi.org/10.1126/science.aba9411DOI Listing

Routine vaccination during covid-19 pandemic response.

BMJ 2020 06 16;369:m2392. Epub 2020 Jun 16.

UCL Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1136/bmj.m2392DOI Listing

Related factor of igg rubella-specific in couples of childbearing age in bolaang mongondow district.

Enferm Clin 2020 Jun;30 Suppl 4:461-464

Occupational Health and Safety Departement, Public Health, Hasanuddin University, Indonesia.

Objective: This study aims to determine the determinant factors associated with the amount of Specific Rubella IgG levels in women of childbearing age.

Methods: The study design used observational analytic with cross-sectional, while sample was women of childbearing age who were in Maelang Health Center, as well as fulfilling the specified inclusion criteria 125 samples.

Results: There was no significant relationship between age (p=0. Read More

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http://dx.doi.org/10.1016/j.enfcli.2019.10.121DOI Listing

Vaccine-associated Rubella - a report of two cases and a review of the literature.

Hum Vaccin Immunother 2020 Jun 12:1-4. Epub 2020 Jun 12.

Department of Microbiology, Singapore General Hospital , Singapore.

We report the clinical characteristics of two adult patients, presenting with a typical erythematous rash consistent with rubella disease after MMR vaccination. Both patients had an uncomplicated clinical course and recovered uneventfully. One patient was confirmed to have vaccine-associated rubella via sequencing of virus isolated in viral culture. Read More

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http://dx.doi.org/10.1080/21645515.2020.1765623DOI Listing
June 2020
2.131 Impact Factor

Intralesional antigen immunotherapy for the treatment of plane warts: A comparative study.

Dermatol Ther 2020 Jun 12:e13807. Epub 2020 Jun 12.

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Intralesional immunotherapy by different antigens has shown promising efficacy and safety in the treatment of warts. However, the use of these antigens for the treatment of plane warts has been investigated in 2 studies only. To evaluate the efficacy and safety of three antigens; Measles Mumps, Rubella vaccine (MMR), Candida antigen, and purified protein derivative (PPD) in the treatment of multiple plane warts. Read More

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http://dx.doi.org/10.1111/dth.13807DOI Listing

Effects of a measles outbreak on vaccination uptake.

Authors:
Thomas Schober

Econ Hum Biol 2020 May 24;38:100871. Epub 2020 May 24.

Johannes Kepler University Linz, Department of Economics, Christian Doppler Laboratory for Aging, Health, and the Labor Market, Altenberger Straße 69, 4040 Linz, Austria. Electronic address:

This paper explores the effects of a measles outbreak on vaccination uptake in Austria, using administrative data with individual-level information on childhood vaccinations. I define a treatment group of children affected by the outbreak, and compare them with a control group of earlier-born children who are unaffected. Twelve months after the outbreak, the vaccination rate of the treatment group is 2. Read More

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http://dx.doi.org/10.1016/j.ehb.2020.100871DOI Listing

Investigating the etiologic agents of aseptic meningitis outbreak in Iranian children.

J Family Med Prim Care 2020 Mar 26;9(3):1573-1577. Epub 2020 Mar 26.

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Nemazi Hospital, Shiraz, Iran.

Introduction: This study aimed to determine the viral agent (s) and their genome burden associated with an aseptic meningitis outbreak that occurred in Yasuj, Iran.

Materials And Methods: During April to August 2015, 104 CSF samples from 104 patients under 14 years old admitted to the hospital of Yasuj, Iran, with aseptic meningitis associated clinical signs were collected. 200 μl CSF specimens was prepared for DNA and RNA viral genome extraction each and then subjected to diagnostic Taq-man real time PCR assays for the present of Enteroviruses, HSV, VZV, mumps, measles and rubella in the samples. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_1003_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266184PMC

Multistate Mumps Outbreak Originating from Asymptomatic Transmission at a Nebraska Wedding - Six States, August-October 2019.

MMWR Morb Mortal Wkly Rep 2020 Jun 5;69(22):666-669. Epub 2020 Jun 5.

In August 2019, 30 attendees at a Nebraska wedding developed mumps after being exposed to one asymptomatic index patient who was fully vaccinated according to Advisory Committee on Immunization Practices (ACIP) recommendations (1), resulting in a multistate outbreak. A public health investigation and response revealed epidemiologic links that extended from the index patient through secondary, tertiary, and quaternary patients and culminated in a measles-mumps-rubella (MMR) booster vaccination campaign in the local community where approximately half of the patients resided. Read More

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http://dx.doi.org/10.15585/mmwr.mm6922a2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272110PMC

The Importance of Advancing SARS-CoV-2 Vaccines in Children.

Clin Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

Department of Pediatrics, Emory University School of Medicine, Emory + Children's Pediatric Institute, Atlanta, GA, USA.

While the role of children in the chain of transmission of SARS-CoV-2 remains to be fully defined, they likely play an important role based on our knowledge of other respiratory viruses. Children are more likely to be asymptomatic or have milder symptoms and less likely to present for healthcare and be tested for SARS-CoV-2; thus, our current estimates are likely under-representative of the true burden of SARS-CoV-2 in children. Given the potential direct benefit of a SARS-CoV-2 vaccine in children and the substantial indirect benefit through community protection or 'herd immunity', we argue that planning and implementation of SARS-CoV-2 vaccines should include children. Read More

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http://dx.doi.org/10.1093/cid/ciaa712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314192PMC

Strategies for elimination of rubella in pregnancy and of congenital rubella syndrome in high and upper-middle income countries.

J Prev Med Hyg 2020 Mar 2;61(1):E98-E108. Epub 2020 Apr 2.

Department of Biomedicine and Prevention, Tor Vergata University of Rome, Italy.

Rubella infection generally leads to mild symptoms; otherwise, in pregnant women it can cause severe damages. The only way to prevent rubella is vaccine. Before the introduction of the vaccine, up to 4 babies in 1000 live births were born with CRS. Read More

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http://dx.doi.org/10.15167/2421-4248/jpmh2020.61.1.1310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225652PMC

Spatiotemporal proximity of rubella cases to the occurrence of congenital rubella syndrome in Yogyakarta, Indonesia.

Med J Malaysia 2020 May;75(Suppl 1):41-47

Universitas Gadjah Mada, Public Health and Nursing, Faculty of Medicine, Department of Child Health, Yogyakarta, Indonesia.

Introduction: Rubella infection during early pregnancy may cause fatal consequences such as congenital rubella syndrome (CRS). The incidence rate (IR) of CRS confirmed cases in Yogyakarta, Indonesia between July 2008 and June 2013 was high at 0.05 per 1,000 live births. Read More

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Evaluating the population measles susceptibility in Tianjin, China.

Vaccine 2020 Jun 29;38(31):4829-4836. Epub 2020 May 29.

Institute for Infectious Diseases Control and Prevention, Tianjin Center for Disease Control and Prevention, 6 Hua Yue Street, Hedong District, Tianjin 300011, China.

Background: Measles is a highly infectious illness requiring herd immunity of 95% to interrupt transmission. China has not reached elimination goals despite high vaccination coverage. We estimated the population susceptibility against measles in Tianjin, China and to tailor awareness raising activities in the measles elimination plan. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.05.053DOI Listing

Pityriasis lichenoides et varioliformis acuta following measles rubella vaccine.

Indian J Dermatol Venereol Leprol 2020 Jul-Aug;86(4):398-400

Department of Dermatology, Venereology and Leprosy, JSS Medical College, Mysore, Karnataka, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_48_18DOI Listing

Seroprevalence of chronic hepatitis B virus infection and immunity to measles, rubella, tetanus and diphtheria among schoolchildren aged 6-7 years old in the Solomon Islands, 2016.

Vaccine 2020 Jun 28;38(30):4679-4686. Epub 2020 May 28.

Global Immunization Division, US Centers for Disease Control and Prevention, Atlanta, United States.

The Western Pacific Region (WPR) established a goal to decrease chronic hepatitis B virus (HBV) infection among children to <1% and to achieve ≥95% hepatitis B vaccine birth dose (HepB-BD) and ≥95% three-dose (HepB3) coverage by 2017. In 2016, we conducted a national serosurvey in the Solomon Islands among 6-7-year-old school children to assess progress towards the control goal and immunity to measles, rubella, tetanus and diphtheria. Eighty schools were selected systematically proportional to their 6-7-year-old population; all 6-7-year-olds were enrolled. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.05.029DOI Listing

Cynanchum paniculatum (Bunge) Kitag. ex H. Hara: A review of its ethnopharmacology, phytochemistry and pharmacology.

J Ethnopharmacol 2020 May 27;260:112994. Epub 2020 May 27.

School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China; Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine, Yinchuan, 750004, China; Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education (Ningxia Medical University), Yinchuan, 750004, China. Electronic address:

Ethnopharmacological Relevance: Cynanchum paniculatum (Bunge) Kitag. ex H. Hara (C. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112994DOI Listing
May 2020
2.998 Impact Factor

Whole-genome sequence analysis of the 24th genotype D11 of measles virus.

Arch Virol 2020 May 27. Epub 2020 May 27.

NHC (National health commission), Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, CDC China, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.

We previously reported genotype D11 strains of measles virus that were first isolated from a measles outbreak associated with imported cases in Yunnan province of China by Zhang et al. (Emerg Infect Dis 16(6):943-7, 2010). Genotype D11 has been identified as the 24th genotype of the WHO reference strains. Read More

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http://dx.doi.org/10.1007/s00705-020-04671-xDOI Listing

Estimation of the wastage rate of MMR and pentavalent vaccines in open and closed vials in three western provinces of Iran.

Heliyon 2020 May 20;6(5):e04016. Epub 2020 May 20.

Technical Officer, Vaccines and Immunization, World Health Organization, Genev, Switzerland.

Background: Vaccine wastage is one of quality indicators of immunization program and high vaccine wastage will increase overall costs and impede efforts towards a more efficient and sustainable program. We aimed at estimating of the wastage rates of Measles-Mumps-Rubella (MMR) and pentavalent (diphtheria-tetanus-pertussis-hepatitis B -Haemophilus influenza type b) vaccines in different vaccine vial sizes.

Study Design: Multicentre descriptive study using existing data. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240321PMC

Rubella retinopathy with choroidal neovascular membrane in a 7-year-old.

Indian J Ophthalmol 2020 Jun;68(6):1176-1177

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

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http://dx.doi.org/10.4103/ijo.IJO_1469_19DOI Listing

Knowledge and Attitude towards Vaccination among Healthcare Workers: A Multicenter Cross-Sectional Study in a Southern Italian Region.

Vaccines (Basel) 2020 May 24;8(2). Epub 2020 May 24.

Department of Medicine and Aging Sciences, "G. d'Annunzio" University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.

: In Italy, the loss of confidence towards vaccination resulted in low vaccine coverage, also among healthcare workers (HCWs). Indeed, low vaccination coverage among HCWs can lead to dangerous outbreaks of disease, reduce productivity, and increase absenteeism. The aim of this study was to investigate the vaccine coverage and attitudes toward vaccination among HCWs. Read More

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http://dx.doi.org/10.3390/vaccines8020248DOI Listing

Incidence of herpes zoster among varicella-vaccinated children, by number of vaccine doses and simultaneous administration of measles, mumps, and rubella vaccine.

Vaccine 2020 May 19. Epub 2020 May 19.

Center for Health Research, Kaiser Permanente Northwest, 3800 North Interstate Avenue, Portland, OR 97227, USA.

Introduction: Children may receive measles-mumps-rubella (MMR) and varicella (VAR) vaccines separately or as measles-mumps-rubella-varicella (MMRV). We examined whether pediatric herpes zoster (HZ) incidence varied by pattern of varicella vaccine administration.

Methods: In six integrated health systems, we examined HZ incidence among children turning 12 months old during 2003-2008. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.05.006DOI Listing

Temporary Fertility Decline after Large Rubella Outbreak, Japan.

Emerg Infect Dis 2020 Jun;26(6):1122-1129

Japan experienced 2 large rubella epidemics in 2004 and 2012-2014. Because of suboptimal immunization levels, the country has been experiencing a third major outbreak during 2018-2020. We conducted time series analyses to evaluate the effect of the 2012-2014 nationwide rubella epidemic on prefecture-level natality in Japan. Read More

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http://dx.doi.org/10.3201/eid2606.181718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258466PMC

Early impact of the coronavirus disease (COVID-19) pandemic and physical distancing measures on routine childhood vaccinations in England, January to April 2020.

Euro Surveill 2020 05;25(19)

Immunisation and Countermeasures Division, Public Health England, Colindale, United Kingdom.

Using electronic health records, we assessed the early impact of coronavirus disease (COVID-19) on routine childhood vaccination in England by 26 April 2020. Measles-mumps-rubella vaccination counts fell from February 2020, and in the 3 weeks after introduction of physical distancing measures were 19.8% lower (95% confidence interval: -20. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2020.25.19.2000848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238742PMC

Compliance with the guidelines on recommended immunization schedule in patients with inflammatory bowel disease: implications on public health policies.

BMC Public Health 2020 May 19;20(1):713. Epub 2020 May 19.

Catalan Health Institute (ICS), Primary Care, Lleida, Spain.

Background: Patients with inflammatory bowel disease (IBD) have a higher risk of developing opportunistic infections due to either the disease itself or to treatment with immunosuppressants. This risk can be reduced through vaccination. The aim of this study was to determine the prevalence of compliance with the guidelines on recommended immunization schedule in patients with IBD in the health district of Lleida, Spain. Read More

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http://dx.doi.org/10.1186/s12889-020-08850-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236120PMC

A double-blind, randomized, multicenter, controlled study to evaluate the immunogenicity, safety, and tolerability of varicella vaccine (VARIVAX™) passage extension 34 (PE34) process administered concomitantly with measles, mumps, and rubella vaccine (M-M-R™ II).

Hum Vaccin Immunother 2020 May 19:1-7. Epub 2020 May 19.

Merck & Co., Inc., Kenilworth, NJ, USA.

The varicella vaccine passage extension (VAR-PE) process was undertaken to extend the availability of varicella zoster virus (VZV)-containing vaccines. This study (V210-A03; NCT03239873) assessed the immunogenicity, safety, and tolerability of VAR-PE process in comparison with varicella vaccine commercial product 2016 (VAR) randomized 1:1 in 600 healthy children 12 to 23 months of age administered concomitantly with measles-mumps-rubella (MMR) vaccine. The VZV seroconversion rate at 6 weeks Postdose 1 in the PP population was 100% for both groups. Read More

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http://dx.doi.org/10.1080/21645515.2020.1743122DOI Listing