Search our Database of Scientific Publications and Authors

I’m looking for a

    14908 results match your criteria Rubella

    1 OF 299

    Long-term balancing selection contributes to adaptation in Arabidopsis and its relatives.
    Genome Biol 2017 Nov 15;18(1):217. Epub 2017 Nov 15.
    State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
    Background: In contrast to positive selection, which reduces genetic variation by fixing beneficial alleles, balancing selection maintains genetic variation within a population or species and plays crucial roles in adaptation in diverse organisms. However, which genes, genome-wide, are under balancing selection and the extent to which these genes are involved in adaptation are largely unknown.

    Results: We performed a genome-wide scan for genes under balancing selection across two plant species, Arabidopsis thaliana and its relative Capsella rubella, which diverged about 8 million generations ago. Read More

    Immunity Following Childhood Vaccinations in Perinatally HIV-Exposed Children with and without HIV Infection in Latin America.
    Pediatr Infect Dis J 2017 Nov 14. Epub 2017 Nov 14.
    1 Escola Paulista de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil 2 Westat, Rockville, MD, USA 3 Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil 4 Clínica de Inmunodeficiencias/Depto. de Infectología, Hospital Infantil de Mexico Federico Gomez, Mexico City 5 Department of Child & Adolescent Health, the University of the West Indies, Jamaica 6 National Institute of Child Health and Faculty of Medicine of National University of San Marcos of Lima Peru 7 Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brasil 8 Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina 9 Instituto de Pesquisas Biomédicas da Pontifícia Universidade Católica do Rio Grande do Sul and Irmandade da Santa Casa de Misericórdia de Porto Alegre, both in Porto Alegre, Brazil 10 Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
    Background: Perinatally HIV-infected (PHIV) children are at risk for undervaccination and poor vaccine response at four years of age. Childhood vaccine coverage and immune response were compared between PHIV and HIV-exposed uninfected (HEU) children in Latin America and the Caribbean.

    Methods: PHIV and HEU children were enrolled prospectively at fifteen sites from 2002-2009. Read More

    A Role of Sp1 Binding Motifs in Basal and Large T-Antigen-Induced Promoter Activities of Human Polyomavirus HPyV9 and Its Variant UF-1.
    Int J Mol Sci 2017 Nov 14;18(11). Epub 2017 Nov 14.
    Division 12, Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients, Robert Koch Institute, 13353 Berlin, Germany.
    Human polyomavirus 9 (HPyV9) was originally detected in the serum of a renal transplant patient. Seroepidemiological studies showed that ~20-50% of the human population have antibodies against this virus. HPyV9 has not yet been associated with any disease and little is known about the route of infection, transmission, host cell tropism, and genomic variability in circulating strains. Read More

    Whole genomic analysis of two potential recombinant strains within Human mastadenovirus species C previously found in Beijing, China.
    Sci Rep 2017 Nov 13;7(1):15380. Epub 2017 Nov 13.
    WHO WPRO Regional Reference Measles/Rubella Laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, No. 155, Changbai Road, Changping District, Beijing, 102206, People's Republic of China.
    Human mastadenovirus species C (HAdV-C) are the most common etiologic agents of respiratory disease in young children and are frequently detected worldwide including China. Two recombinant HAdV-C strains (BJ04 and BJ09) were isolated from infants with acute respiratory infection (ARI) in Beijing in 2012-2013. The whole genome sequences (WGS) of BJ04 and BJ09 were generated and compared to other 35 HAdV-C WGSs publicly available. Read More

    Measuring the timeliness of childhood vaccinations: Using cohort data and routine health records to evaluate quality of immunisation services.
    Vaccine 2017 Nov 10. Epub 2017 Nov 10.
    Population, Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK. Electronic address:
    Background: To achieve full benefits of vaccination programmes, high uptake and timely receipt of vaccinations are required.

    Objectives: To examine uptake and timeliness of infant and pre-school booster vaccines using cohort study data linked to health records.

    Methods: We included 1782 children, born between 2000 and 2001, participating in the Millennium Cohort Study and resident in Wales, whose parents gave consent for linkage to National Community Child Health Database records at the age seven year contact. Read More

    Pediatric Cataract - Importance of Early Detection and Management.
    Indian J Pediatr 2017 Nov 9. Epub 2017 Nov 9.
    Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.
    Pediatric cataract is often diagnosed and managed late. This delay may be due to the ignorance on the part of the community, financial constraints, delay in the diagnosis and lack of tertiary care facilities. There is an urgent need to include rubella vaccination in the universal immunization program. Read More

    Mumps: An Emergency Medicine-Focused Update.
    J Emerg Med 2017 Oct 27. Epub 2017 Oct 27.
    Department of Emergency Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.
    Background: Mumps is a Paramyxoviridae virus. This disease was rampant prior to introduction of the measles, mumps, and rubella vaccine, resulting in decreased incidence. This disease has demonstrated several outbreaks. Read More

    Structural basis for receptor recognition of pollen tube attraction peptides.
    Nat Commun 2017 Nov 6;8(1):1331. Epub 2017 Nov 6.
    Ministry of Education Key Laboratory of Protein Science, Center for Structural Biology, School of Life Sciences, Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, 100084, Beijing, China.
    Transportation of the immobile sperms directed by pollen tubes to the ovule-enclosed female gametophytes is important for plant sexual reproduction. The defensin-like (DEFL) cysteine-rich peptides (CRPs) LUREs play an essential role in pollen tube attraction to the ovule, though their receptors still remain controversial. Here we provide several lines of biochemical evidence showing that the extracellular domain of the leucine-rich repeat receptor kinase (LRR-RK) PRK6 from Arabidopsis thaliana directly interacts with AtLURE1 peptides. Read More

    Low intrathecal antibody production despite high seroprevalence of Epstein-Barr virus in multiple sclerosis: a review of the literature.
    J Neurol 2017 Nov 2. Epub 2017 Nov 2.
    Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany.
    Background: Patients with multiple sclerosis (MS) frequently have an intrathecal production of antibodies to different common viruses, which can be detected by elevated antiviral antibody indices (AIs). There is a strong and consistent association of MS and Epstein-Barr virus (EBV) infection.

    Objective: To systematically compare the frequencies of intrathecal antibody production to EBV, measles virus, rubella virus, varicella zoster virus (VZV) and herpes simplex virus (HSV) in patients with MS. Read More

    Vaccination Coverage Among Children Aged 19-35 Months - United States, 2016.
    MMWR Morb Mortal Wkly Rep 2017 Nov 3;66(43):1171-1177. Epub 2017 Nov 3.
    Immunization Services Division, National Center for Immunization and Respiratory Diseases, CDC.
    Vaccination is the most effective intervention to reduce morbidity and mortality from vaccine-preventable diseases in young children (1). Data from the 2016 National Immunization Survey-Child (NIS-Child) were used to assess coverage with recommended vaccines (2) among children aged 19-35 months in the United States. Coverage remained ≥90% for ≥3 doses of poliovirus vaccine (91. Read More

    Novel polyomaviruses in shrews (Soricidae) with close similarity to human polyomavirus 12.
    J Gen Virol 2017 Nov 2. Epub 2017 Nov 2.
    7​Division 12 'Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients', Robert Koch Institute, Berlin, Germany.
    Shrews (family Soricidae) have already been reported to host microorganisms pathogenic for humans. In an effort to search for additional infectious agents with zoonotic potential, we detected polyomaviruses (PyVs) in common shrew, crowned shrew, and pygmy shrew (Sorex araneus, S. coronatus and S. Read More

    Investigating the assumptions of the self-controlled case series method.
    Stat Med 2017 Nov 2. Epub 2017 Nov 2.
    School of Mathematics and Statistics, The Open University, Milton Keynes, UK.
    We describe some simple techniques for investigating 2 key assumptions of the self-controlled case series (SCCS) method, namely, that events do not influence subsequent exposures and that events do not influence the length of observation periods. For each assumption, we propose some simple tests based on the standard SCCS model, along with associated graphical displays. The methods also enable the user to investigate the robustness of the results obtained using the standard SCCS model to failure of assumptions. Read More

    Hydrocephalus associated to congenital Zika syndrome: does shunting improve clinical features?
    Childs Nerv Syst 2017 Oct 30. Epub 2017 Oct 30.
    Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
    Purpose: Congenital Zika syndrome (CZS) is a new entity with little information about its course and natural history. It is known that prenatal infection by Zika virus is associated to disrupted nervous system development, leading to typical neurological disabilities and deformities. Some children present progressive ventriculomegaly and hydrocephalus associated to aggravation of seizures and neurological impairment. Read More

    Genital Tract Screening Finds Widespread Infection with Mustelid Gammaherpesvirus 1 in the European Badger (Meles meles).
    J Wildl Dis 2017 Oct 27. Epub 2017 Oct 27.
    1 Wildlife Conservation Research Unit, Department of Zoology, University of Oxford, The Recanati-Kaplan Centre, Tubney House, Abingdon Road, Tubney, Abingdon OX13 5QL, UK.
    Sexually transmitted diseases (STDs) can be important drivers of population dynamics because of their negative effects on reproduction. However, screening for STDs, especially in wildlife populations, is widely neglected. Using the promiscuous, polygynandrous European badger (Meles meles) as a model, we investigated the presence and prevalence of herpesviruses (HVs) in a wild, high-density population and assessed potential differences in somatic fitness and female reproductive condition between infected and uninfected individuals. Read More

    Measles, mumps, rubella, and varicella among service members and other beneficiaries of the Military Health System, 2010-2016.
    MSMR 2017 Oct;24(10):2-11
    Measles, mumps, rubella, and varicella (MMR/V) are highly communicable infectious diseases whose causative agents are spread through contact with contaminated surfaces or airborne droplets. Individuals at highest risk for MMR/V infections include infants, unvaccinated or inadequately vaccinated persons, individuals living in communities with low vaccination rates or in crowded and unsanitary conditions, and persons with compromised immune systems. During 2010-2016, there were 11 confirmed measles cases and 76 confirmed mumps cases among all Military Health System (MHS) beneficiaries. Read More

    Large choroidal excavation in a patient with rubella retinopathy.
    Eur J Ophthalmol 2017 Oct 17. Epub 2017 Oct 17.
    Department of Ophthalmology, Vita-Salute University, Ospedale San Raffaele, Milan - Italy.
    Purpose: To describe a case of rubella retinopathy complicated by bilateral choroidal neovascularization (CNV) and late development of large choroidal excavation (LCE).

    Methods: A 19-year-old woman with a diagnosis of rubella retinopathy underwent her annual ophthalmologic examination, including visual acuity testing and slit-lamp biomicroscopy with dilated fundus examination. Color fundus photography, spectral-domain optical coherence tomography (SD-OCT) scans, and optical coherence tomography angiography were acquired to complete the investigation of her ocular condition. Read More

    Both sphingomyelin and cholesterol in the host cell membrane are essential for Rubella virus entry.
    J Virol 2017 Oct 25. Epub 2017 Oct 25.
    Department of Virology 3Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo, Japan
    Rubella virus (RuV) causes a systemic infection and transplacental fetal infection causes congenital rubella syndrome. In this study, we showed that treatment of cells with sphingomyelinase inhibited RuV infection. Assays using inhibitors of serine palmitoyl transferase and ceramide transport protein demonstrated the contribution of sphingomyelin (SM) to RuV infection. Read More

    Clinical profile of congenital rubella syndrome in Yogyakarta Indonesia.
    Pediatr Int 2017 Oct 25. Epub 2017 Oct 25.
    Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada/Dr, Sardjito Hospital, Yogyakarta, Indonesia.
    Background: Congenital rubella syndrome (CRS) has many severe neurological manifestations and other systemic consequences in patients. Although various studies have been done in Indonesia, there have not been any conclusive results on CRS incidence. Therefore, we aimed to investigate the incidence, clinical manifestations and outcomes of CRS in Yogyakarta, Indonesia. Read More

    Expansion of Vaccination Services and Strengthening Vaccine-Preventable Diseases Surveillance in Haiti, 2010-2016.
    Am J Trop Med Hyg 2017 Oct;97(4_Suppl):28-36
    Centers for Disease Control and Prevention, Port-au-Prince, Haiti.
    Following the 2010 earthquake, Haiti was at heightened risk for vaccine-preventable diseases (VPDs) outbreaks due to the exacerbation of long-standing gaps in the vaccination program and subsequent risk of VPD importation from other countries. Therefore, partners supported the Haitian Ministry of Health and Population to improve vaccination services and VPD surveillance. During 2010-2016, three polio, measles, and rubella vaccination campaigns were implemented, achieving a coverage > 90% among children and maintaining Haiti free of those VPDs. Read More

    Implementing near real-time vaccine safety surveillance using the Clinical Practice Research Datalink (CPRD).
    Vaccine 2017 Oct 19. Epub 2017 Oct 19.
    Statistics, Modelling and Economics Department, Public Health England, London NW9 5 EQ, United Kingdom.
    Introduction: Near real-time vaccine safety surveillance (NRTVSS) using electronic health records is increasingly used to rapidly detect vaccine safety signals. NRTVSS has not been fully implemented in the UK. We assessed the feasibility of implementing this surveillance using the UK Clinical Practice Research Datalink (CPRD). Read More

    Infection of iPSC Lines with Miscarriage-Associated Coxsackievirus and Measles Virus and Teratogenic Rubella Virus as a Model for Viral Impairment of Early Human Embryogenesis.
    ACS Infect Dis 2017 Oct 26. Epub 2017 Oct 26.
    Institute of Virology, University of Leipzig , Johannisallee 30, 04103 Leipzig, Germany.
    Human induced pluripotent stem cell (iPSC) lines are a promising model for the early phase of human embryonic development. Here, their contribution to the still incompletely understood pathogenesis of congenital virus infections was evaluated. The infection of iPSC lines with miscarriage-associated coxsackievirus B3 (CVB3) and measles virus (MV) was compared to the efficient teratogen rubella virus (RV). Read More

    County-level assessment of United States kindergarten vaccination rates for measles mumps rubella (MMR) for the 2014-2015 school year.
    Vaccine 2017 Nov 14;35(47):6444-6450. Epub 2017 Oct 14.
    Computational Epidemiology Group, Children's Hospital Informatics Program, Division of Emergency Medicine, Boston Children's Hospital, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address:
    United States kindergarten measles-mumps-rubella (MMR) vaccination rates are typically reported at the state level by the Centers for Disease Control and Prevention (CDC). The lack of local MMR data prevents identification of areas with low vaccination rates that would be vulnerable to the spread of disease. We collected county-level vaccination rates for the 2014-2015 school year with the objective of identifying these regions. Read More

    Measles and rubella elimination: learning from polio eradication and moving forward with a diagonal approach.
    Expert Rev Vaccines 2017 Dec 23;16(12):1203-1216. Epub 2017 Oct 23.
    b Division of Infectious Diseases, Department of Medicine , Emory University School of Medicine , Atlanta , GA , USA.
    Introduction: In 1988, an estimated 350,000 children were paralyzed by polio and 125 countries reported polio cases, the World Health Assembly passed a resolution to achieve polio eradication by 2000, and the Global Polio Eradication Initiative (GPEI) was established as a partnership focused on eradication. Today, following eradication efforts, polio cases have decreased >99% and eradication of all three types of wild polioviruses is approaching. However, since polio resources substantially support disease surveillance and other health programs, losing polio assets could reverse progress toward achieving Global Vaccine Action Plan goals. Read More

    Update From the Advisory Committee on Immunization Practices.
    J Pediatric Infect Dis Soc 2017 Sep 25. Epub 2017 Sep 25.
    Department of Pediatrics, University of Alabama at Birmingham.
    The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Read More

    'Hesitant compliers': Qualitative analysis of concerned fully-vaccinating parents.
    Vaccine 2017 Oct 11. Epub 2017 Oct 11.
    School of Population and Global Health, The University of Western Australia, Australia; Telethon Kids Institute, The University of Western Australia, Australia.
    Objective: Some parents are hesitant about vaccines and yet still vaccinate their children. Vaccine behaviours are not fixed and parents who are concerned but nonetheless adherent to standard schedules could switch to an unconventional schedule, delaying or cherry-picking vaccines. There is a need to better understand vaccine hesitancy in specific contexts, acknowledging cultural and geographical variation, to ensure interventions targeting hesitancy are well directed and received. Read More

    Timeliness of childhood vaccination in the Federated States of Micronesia.
    Vaccine 2017 Nov 10;35(47):6404-6411. Epub 2017 Oct 10.
    Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Immunization Services Division, Atlanta, GA, United States.
    Background: Vaccination coverage is typically measured as the proportion of individuals who have received recommended vaccine doses by the date of assessment. This approach does not provide information about receipt of vaccines by the recommended age, which is critical for ensuring optimal protection from vaccine-preventable diseases (VPDs).

    Objective: To assess vaccination timeliness in the Federated States of Micronesia (FSM), and the projected impact of suboptimal vaccination in the event of an outbreak. Read More

    Effectiveness of Measles Vaccination and Immune Globulin Post-Exposure Prophylaxis in an Outbreak Setting-New York City, 2013.
    Clin Infect Dis 2017 Nov;65(11):1843-1847
    New York City Department of Health and Mental Hygiene, New York.
    Background: Measles, mumps, and rubella vaccine (MMR) or immune globulin (IG) are routinely used for measles post-exposure prophylaxis (PEP). However, current literature on the effectiveness of measles PEP is limited and variable. Here, we examined the effectiveness of MMR and IG PEP among children exposed to measles during an outbreak in New York City (NYC) in 2013. Read More

    Vaccination Coverage for Selected Vaccines, Exemption Rates, and Provisional Enrollment Among Children in Kindergarten - United States, 2016-17 School Year.
    MMWR Morb Mortal Wkly Rep 2017 Oct 13;66(40):1073-1080. Epub 2017 Oct 13.
    State and local school vaccination requirements help protect students and communities against vaccine-preventable diseases (1). CDC reports vaccination coverage and exemption data for children attending kindergarten (kindergartners) collected by federally funded immunization programs in the United States.* The typical age range for kindergartners is 4-6 years. Read More

    Mumps outbreak in a highly vaccinated university-affiliated setting before and after a measles-mumps-rubella (MMR) vaccination campaign-Iowa, July 2015-May 2016.
    Clin Infect Dis 2017 Aug 16. Epub 2017 Aug 16.
    Centers for Disease Control and Prevention, Atlanta, GA.
    Background: In response to a mumps outbreak at the University of Iowa and surrounding community, university, state, and local health officials implemented a vaccination campaign targeting students <25 years of age with an additional dose of measles-mumps-rubella (MMR) vaccine. Over 4,700 vaccine campaign doses were administered; 97% were documented third doses. We describe the epidemiology of the outbreak before and after the campaign, focusing on cases in university students. Read More

    Screening investigations in small-for-gestational-age near-term and term infants.
    Eur J Pediatr 2017 Dec 10;176(12):1707-1712. Epub 2017 Oct 10.
    Monash Newborn, Monash Children's Hospital, Melbourne, Australia.
    The aims of this study are to examine how frequently near-term and term small-for-gestational-age (SGA) infants were investigated in our clinical practice, whether being born less than the third centile for weight increased the yield of positive investigations, and whether there were additional characteristics in infants with positive investigations. This retrospective cohort study was compiled using a database of a large maternity network, using the search near term and term gestational age (greater than or equal to 35 weeks) over a span of 4 years. SGA babies were further filtered into less than the tenth centile and third centile. Read More

    Development of A Machine Learning Algorithm to Classify Drugs Of Unknown Fetal Effect.
    Sci Rep 2017 Oct 9;7(1):12839. Epub 2017 Oct 9.
    Department of Biomedical Informatics, Columbia University, New York, USA.
    Many drugs commonly prescribed during pregnancy lack a fetal safety recommendation - called FDA 'category C' drugs. This study aims to classify these drugs into harmful and safe categories using knowledge gained from chemoinformatics (i.e. Read More

    Emergent Lineages of Mumps Virus Suggest the Need for a Polyvalent Vaccine.
    Int J Infect Dis 2017 Oct 4. Epub 2017 Oct 4.
    University of New England, Biddeford, Maine USA.
    Mumps outbreaks among vaccinated patients have become increasingly common in recent years. While there are multiple conditions driving this re-emergence, convention has suggested that these outbreaks are associated with waning immunity rather than vaccine escape. Molecular evidence from both the ongoing American and Dutch outbreaks in conjunction with recent structural biology studies challenge this convention, and suggest that emergent lineages of mumps virus exhibit key differences in antigenic epitopes from the employed vaccine strain Jeryl-Lynn 5. Read More

    Rubella virus infection and associated factors among pregnant women attending the antenatal care clinics of public hospitals in Hawassa City, Southern Ethiopia: a cross-sectional study.
    BMJ Open 2017 Oct 5;7(10):e016824. Epub 2017 Oct 5.
    Department of Medical Laboratory Science, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.
    Objective: To assess the seroprevalence of recent/acute and past exposure to rubella virus infection and associated risk factors among pregnant women.

    Design: A hospital-based cross-sectional study.

    Setting: The study was conducted in two public hospitals in Hawassa City, Southern Ethiopia. Read More

    The pathogenesis of microcephaly resulting from congenital infections: why is my baby's head so small?
    Eur J Clin Microbiol Infect Dis 2017 Oct 5. Epub 2017 Oct 5.
    Department of Virology, Faculty of Basic Medical Sciences, Tarbiat Modares University, Tehran, Iran.
    The emergence of Zika-virus-associated congenital microcephaly has engendered renewed interest in the pathogenesis of microcephaly induced by infectious agents. Three of the original "TORCH" agents are associated with an appreciable incidence of congenital microcephaly: cytomegalovirus, rubella virus, and Toxoplasma gondii. The pathology of congenital microcephaly is characterized by neurotropic infectious agents that involve the fetal nervous system, leading to brain destruction with calcifications, microcephaly, sensorineural hearing loss, and ophthalmologic abnormalities. Read More

    Inhibition of rubella virus replication by the broad-spectrum drug nitazoxanide in cell culture and in a patient with a primary immune deficiency.
    Antiviral Res 2017 Nov 30;147:58-66. Epub 2017 Sep 30.
    Division of Viral Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS C22, Atlanta, GA 30333, USA. Electronic address:
    Persistent rubella virus (RV) infection has been associated with various pathologies such as congenital rubella syndrome, Fuchs's uveitis, and cutaneous granulomas in patients with primary immune deficiencies (PID). Currently there are no drugs to treat RV infections. Nitazoxanide (NTZ) is an FDA-approved drug for parasitic infections, and has been recently shown to have broad-spectrum antiviral activities. Read More

    Rubella Seropositivity in Pregnant Women After Vaccination Campaign in Brazil's Federal District.
    Viral Immunol 2017 Nov 3;30(9):675-677. Epub 2017 Oct 3.
    2 Methodologies Applied to Infectious Diseases Laboratory, School of Medicine, University of Brasilia , Brasilia, Brazil .
    Rubella is an acute viral disease that usually does not generate sequels; however, in pregnant women the infection can cause serious abnormalities to fetuses, which are collectively called congenital rubella syndrome. In Brazil, population immunization was started in 1992, but few epidemiological studies have been conducted to assess vaccination coverage and seroconversion since then. The aim of this work is to evaluate the seropositivity of pregnant women to rubella virus after vaccination campaign was carried out in 2008. Read More

    The hUC-MSCs cell line CCRC-1 represents a novel, safe and high-yielding HDCs for the production of human viral vaccines.
    Sci Rep 2017 Oct 2;7(1):12484. Epub 2017 Oct 2.
    Cell Collection and Research Center, National Institutes for Food and Drug Control, Beijing, 100050, PR China.
    MRC-5 represents the most frequent human diploid cells (HDCs)-type cell substrate in the production of human viral vaccines. However, early-passage MRC-5 is diminishing and, due to both technical and ethical issues, it is extremely difficult to derive novel HDCs from fetal lung tissues, which are the common sources of HDCs. Our previous studies suggested that human umbilical cord may represent an alternative but convenient source of new HDCs. Read More

    Comparison of rubella immunization rates in immigrant and Italian women of childbearing age: Results from the Italian behavioral surveillance system PASSI (2011-2015).
    PLoS One 2017 2;12(10):e0178122. Epub 2017 Oct 2.
    National Centre for Epidemiology, Surveillance and Health Promotion (CNESPS), Italian National Institute of Health (ISS), Rome, Italy.
    Background: International migration rapidly increased in the last decade, raising a renewed attention to its impact on public health. We evaluated differences in rubella immunization rate (RIR) between immigrant and Italian women of childbearing age and tried to identify the driving factors causing them.

    Methods: We analyzed data from the Italian behavioral surveillance system PASSI collected in 2011-2015 in a nationally representative sample of residents in Italy. Read More

    Assessing the cost-effectiveness of different measles vaccination strategies for children in the Democratic Republic of Congo.
    Vaccine 2017 Oct 28;35(45):6187-6194. Epub 2017 Sep 28.
    Department of Epidemiology, UCLA Fielding School of Public Health, 650 S Charles E Young Drive, Los Angeles, CA 90095, USA. Electronic address:
    Introduction: One of the goals of the Global Measles and Rubella Strategic Plan is the reduction in global measles mortality, with high measles vaccination coverage as one of its core components. While measles mortality has been reduced more than 79%, the disease remains a major cause of childhood vaccine preventable disease burden globally. Measles immunization requires a two-dose schedule and only countries with strong, stable immunization programs can rely on routine services to deliver the second dose. Read More

    CHRONOVAC VOYAGEUR: A study of the immune response to yellow fever vaccine among infants previously immunized against measles.
    Vaccine 2017 Oct 25;35(45):6166-6171. Epub 2017 Sep 25.
    Institut Pasteur, Unité de Recherche et d'Expertise Epidémiologie des Maladies Emergentes, Paris, France; Institut Pasteur de Dakar, Unité d'épidémiologie des Maladies Infectieuses, Senegal.
    For administration of multiple live attenuated vaccines, the Advisory Committee on Immunization Practices recommends either simultaneous immunization or period of at least 28days between vaccines, due to a possible reduction in the immune response to either vaccine. The main objective of this study was to compare the immune response to measles (alone or combined with mumps and rubella) and yellow fever vaccines among infants aged 6-24months living in a yellow fever non-endemic country who had receivedmeasles and yellow fever vaccines before travelling to a yellow fever endemic area.

    Subjects And Methods: A retrospective, multicenter case-control study was carried out in 7 travel clinics in the Paris area from February 1st 2011 to march 31, 2015. Read More

    Infant immunization coverage in Italy (2000-2016).
    Ann Ist Super Sanita 2017 Jul-Sep;53(3):231-237
    Direzione Generale della Prevenzione Sanitaria, Ministero della Salute, Rome, Italy.
    Background: In Italy, national-level immunization polices are included in the National Immunization Prevention Plan (PNPV), whose latest edition - 2017-2019 PNPV - was finally approved in February 2017. Coverage rates are a key measure of immunization system performance; it can inform and support national and regional polices' implementation monitoring, as well as measure the impact of interventions aimed at increasing vaccine uptake.

    Methods: We collected, analysed and critically interpreted 2000-2016 Italian national infant immunization coverage trends, by different vaccine, target population, and by Region. Read More

    Detection of human parvovirus B19 in serum samples from children under 5 years of age with rash-fever illnesses in the Democratic Republic of the Congo.
    Int J Infect Dis 2017 Sep 22;65:4-7. Epub 2017 Sep 22.
    University Hospital of Kinshasa, Faculty of Medicine, Department of Microbiology, Kinshasa, Congo; National Institute for Biomedical Research (INRB), Kinshasa, Congo.
    Background: It has been demonstrated that infection with human parvovirus B19 (B19V) is associated with rash-fever illnesses. The present study aimed to investigate B19V as an aetiological agent of rash-fever syndromes in Congolese children confirmed as measles and rubella IgM-negative. An ELISA IgM test and PCR were performed to screen for B19V. Read More

    Complete Genome Sequence of a Genotype 2B Rubella Virus Isolated in South Korea in 2015.
    Genome Announc 2017 Sep 21;5(38). Epub 2017 Sep 21.
    Division of Respiratory Viruses, Center for Infectious Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju-si, Chungbuk, South Korea
    The complete genome sequence of the wild-type genotype 2B rubella virus RVi/Busan.KOR/10.15[2B], isolated from a patient in South Korea, was determined. Read More

    Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 - what is making elimination so difficult?
    Euro Surveill 2017 Sep;22(37)
    Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
    We report an ongoing measles outbreak in Italy, with over 4,400 cases reported in 20 Regions from January to August 2017. Median age was 27 years, 88% of the cases were unvaccinated. The highest incidence was in infants below one year of age and 7% of cases occurred among healthcare workers. Read More

    Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.
    Nat Commun 2017 Sep 19;8(1):599. Epub 2017 Sep 19.
    23andMe, Mountain View, CA, 94041, USA.
    Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P < 5 × 10(-8)) associations in genes with key roles in immunity and embryonic development. Read More

    A novel measles outbreak control strategy in the Netherlands in 2013-2014 using a national electronic immunization register: A study of early MMR uptake and its determinants.
    Vaccine 2017 Oct 18;35(43):5828-5834. Epub 2017 Sep 18.
    National Institute for Public Health and the Environment, Centre for Infectious Disease Control, Bilthoven, The Netherlands. Electronic address:
    Background: During a large measles outbreak in the Netherlands in 2013-2014, infants aged 6-14months living in municipalities with low (<90%) measles-mumps-rubella (MMR) coverage were individually invited for an early MMR using the national electronic immunization register, Præventis. We estimated uptake of early MMR prior to and during the 2013-2014 outbreak and assessed determinants for early MMR vaccination.

    Methods: We obtained vaccination records from Præventis, and defined early MMR as vaccination before 415days (13months) of age. Read More

    Preliminary findings indicate nosocomial transmission and Roma population as most affected group in ongoing measles B3 genotype outbreak in Bulgaria, March to August 2017.
    Euro Surveill 2017 Sep;22(36)
    Bulgarian Association for Prevention and Infection Control - BulNoso, NGO, Sofia, Bulgaria.
    From March to August 2017, 165 measles cases were reported from three regions in Bulgaria. The age range was 0-55 years and 66% of the cases were under 9 years. The Roma population was disproportionally affected (89% of cases), 41% cases were unvaccinated and in 24 cases there was nosocomial transmission mostly in paediatric departments. Read More

    Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016.
    PLoS One 2017 15;12(9):e0185048. Epub 2017 Sep 15.
    WHO WPRO Regional Reference Measles/Rubella laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing City, People's Republic of China.
    From April to November 2016, two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively at primary and middle schools in the Tibet Autonomous Region of China, and a total of 197 clinically diagnosed cases were reported. Real-time PCR analyses confirmed that human adenovirus (HAdV) infection was related to these outbreaks. Further studies involving sequence determination and phylogenetic analysis based on the penton base, hexon, and fiber genes indicated that human adenovirus type 8 (HAdV-8), belonging to species D, was responsible for the outbreaks. Read More

    1 OF 299