15,437 results match your criteria Rubella


[Development of a test kit for the detection of IgG-antibodies to individual antigens of Rubella virus by immunoblotting (Western blot).]

Klin Lab Diagn 2018 ;63(11):696-701

Closed Joint Stock Company «EKOlab», 142530, Elektrogorsk, Moscow region, Russian Federation.

A Russian test kit for detecting IgG-antibodies to individual antigens of Rubella virus by immunoblotting (Western Blot) was designed. The new test kit is intended for confirmation of positive screening results and for differentiation of stages of infection. It has sensitivity and specificity not conceding one of its analogues, the «Anti-Rubella virus (IgG) WESTERNBLOT» («EUROIMMUN AG», Germany). Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-11-696-701DOI Listing
January 2018

The Efficacy and Safety of Intralesional Immunotherapy with Measles, Mumps, Rubella Virus Vaccine for the Treatment of Common Warts in Adults.

Indian Dermatol Online J 2019 Jan-Feb;10(1):19-26

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.

Background: Most therapeutic modalities for common warts remain unsatisfactory.

Objectives: To evaluate efficacy and safety of intralesional MMR (measles, mumps, rubella virus) vaccine in the treatment of common warts in adults.

Patients And Methods: There were 110 (M:F = 61:49) patients aged 19-62 years having 1-211 warts over dorsal hands, feet, palms, soles, and periungual skin for 1-252 months. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_142_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362737PMC
February 2019

Clinical Manifestations, Prognosis And Vaccination Status Of Patients With Rubella Virus-Associated Uveitis.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Purpose: To assess the clinical and laboratory manifestations and vaccination status of uveitis patients positive for Rubella virus (RV) in aqueous humor and investigate its relationship to Fuchs Uveitis Syndrome (FUS).

Methods: Retrospective study of all uveitis patients, positive for RV in aqueous humor analysis (polymerase chain reaction (PCR) and/or Goldmann-Witmer coefficient (GWC)) between January 2010 and October 2016 at the ophthalmology departments in the Erasmus Medical Center (Rotterdam) and University Medical Center Utrecht. Outcomes of aqueous analyses of FUS patients during this period were assessed. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.002DOI Listing
February 2019

Status of Measles Elimination in Eleven Countries with High Routine Immunisation Coverage in The WHO African Region.

J Immunol Sci 2018 Jul;Suppl:140-144

WHO Regional Office for Africa, Brazzaville, Congo.

Background: Measles elimination is defined as the absence of endemic measles virus transmission in a defined geographic area for at least 12 months in the presence of a well-performing surveillance system. The WHO framework for verification of measles elimination indicates that the achievement of measles and/or rubella elimination should be verified for individual countries.

Objective: We identified 11 high performing countries based on their first dose measles vaccination coverage, and looked at their performance across the various programmatic parameters, to see if they are ready to undertake the verification of measles elimination. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372061PMC

Long-term protection against varicella with two-dose combination measles-mumps-rubella-varicella vaccine.

Lancet Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

National Centre for Immunisation Research and Surveillance, Westmead, NSW 2145, Australia. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30797-7DOI Listing
February 2019

Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine or one dose of monovalent varicella vaccine: 10-year follow-up of a phase 3 multicentre, observer-blind, randomised, controlled trial.

Lancet Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

University of Defence, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic; Charles University, Faculty of Medicine in Hradec Kralove, Department of Social Medicine, Hradec Kralove, Czech Republic.

Background: The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V), versus two MMR doses (control vaccine) for the prevention of confirmed varicella.

Methods: This was a phase 3b follow-up of an observer-blinded, randomised, controlled trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14733099183071
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http://dx.doi.org/10.1016/S1473-3099(18)30716-3DOI Listing
February 2019
3 Reads

Early disappearance of maternal anti-measles, mumps, rubella, and varicella antibodies in Indian infants.

Vaccine 2019 Feb 11. Epub 2019 Feb 11.

Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed To Be University), Pune, India. Electronic address:

Background: Immunization of children with vaccines against Measles, Mumps, Rubella, and Varicella (MMRV) is practiced globally with varied recommendations. In India, measles vaccine is administered alone or as MMR at 9 months age. Varicella vaccine is not routinely used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193011
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http://dx.doi.org/10.1016/j.vaccine.2019.01.043DOI Listing
February 2019
1 Read

Vaccination Against Measles, Mumps, and Rubella in the Light of Current Epidemic Threats: Unjustified Postponement.

Adv Exp Med Biol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics with Clinical Assessment Unit, Warsaw Medical University, Warsaw, Poland.

A worrying increase in the number of measles cases has been noted recently in Poland, which may have to do with a decreasing proportion of children vaccinated against measles, mumps, and rubella (MMR) in the second year of life (<95%). For many years, MMR vaccination in children has been associated with a fear of allergy to eggs. This study seeks to define the reason and justification for postponing MMR vaccination in a population of children referred to the outpatient specialist immunization clinic. Read More

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http://dx.doi.org/10.1007/5584_2019_344DOI Listing
February 2019

Timeliness and completeness of routine childhood vaccinations in young children residing in a district with recurrent vaccine-preventable disease outbreaks, Jerusalem, Israel.

Euro Surveill 2019 Feb;24(6)

Chief Scientist, Ministry of Health, Jerusalem, Israel.

BackgroundChildhood vaccination schedules recommend vaccine doses at predefined ages.AimWe evaluated vaccination completeness and timeliness in Jerusalem, a district with recurrent vaccine-preventable disease outbreaks.MethodsVaccination coverage was monitored by the up-to-date method (vaccination completeness at age 2 years). Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.6.1800004DOI Listing
February 2019

[Vaccination Controversies: An Adult Case of Post-Vaccinal Acute Disseminated Encephalomyelitis].

Acta Med Port 2019 Feb 1;32(1):81-85. Epub 2019 Feb 1.

Departamento de Neurologia. Hospital da Luz. Lisboa. Portugal.

Acute disseminated encephalomyelitis is a rare inflammatory demyelinating multifocal disease of the central nervous system that typically occurs in children following vaccination or exanthematous viral infections and conveys an elevated risk of neurological sequelae unless promptly recognized and treated. We describe an adult case of acute disseminated encephalomyelitis following vaccination against Mumps, Measles and Rubella, presenting with fever and progressive neurological deficits which improved under systemic corticosteroid therapy. Considering the ongoing public debate regarding universal vaccination and the surge of previously controlled infectious diseases, we aim not only to underline the need for a rigorous assessment of vaccination safety on adult patients in order to prevent misguidance of public opinion, but also to alert clinicians for an early diagnosis of acute disseminated encephalomyelitis in these patients, the incidence of which we speculate may be rising. Read More

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http://dx.doi.org/10.20344/amp.9809DOI Listing
February 2019
1 Read

Descriptive Study of Rubella Titer Status in Infertility Patients.

S D Med 2018 Nov;71(11):495-499

Sanford Health Fertility and Reproductive Medicine, Sioux Falls, South Dakota.

Introduction: There is a 6.4 percent incidence of rubella exposure during pregnancy in the U.S. Read More

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November 2018
1 Read

Evaluation of the Abbott ARCHITECT™ cytomegalovirus IgM/IgG, rubella IgM/IgG, and syphilis treponemal antibodies enzyme immunoassays in a mother and child health center population.

Diagn Microbiol Infect Dis 2019 Jan 17. Epub 2019 Jan 17.

Université de Montréal, 2900 Boulevard Édouard-Montpetit, Montréal, Québec, Canada, H3T 1J4; Centre Hospitalier Universitaire Sainte-Justine, 3175 Chemin de la Côte Sainte-Catherine, Montreal, Quebec, Canada, H3T 1C4.

This study evaluated the concordance of Architect™ chemiluminescent microparticle immunoassays with Captia™ ELISA for cytomegalovirus (CMV) IgM and IgG, with Enzygnost™ and Captia™ ELISA for rubella IgM and IgG and with Trep-Sure™ ELISA for syphilis treponemal antibodies in a mixed pediatric and obstetrical population. Total agreement between assays and Kappa statistic value were 82.5% (95% CI: 75. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07328893193002
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http://dx.doi.org/10.1016/j.diagmicrobio.2018.12.017DOI Listing
January 2019
2 Reads

Comparison of the whole genome sequence of an Oka varicella vaccine from China with other Oka vaccine strains reveals sites putatively critical for vaccine efficacy.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

NHC Key Laboratory of Medical Virology and Viral Diseases (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention), WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing 102206, People's Republic of China.

Varicella-Zoster Virus (VZV) infection results in varicella mostly in children. Reactivation of the virus causes Herpes Zoster (HZ) mostly in adults. A live attenuated vaccine (vOka-Biken hereafter) was originally derived from the parental strain pOka. Read More

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http://dx.doi.org/10.1128/JVI.02281-18DOI Listing
February 2019
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Immunogenicity and safety of the new MMR vaccine containing measles AIK-C, rubella Takahashi, and mumps RIT4385 strains in Japanese children: a randomized phase I/II clinical trial.

Hum Vaccin Immunother 2019 Feb 6. Epub 2019 Feb 6.

b Japan Vaccine Co., Ltd .

Domestic measles, mumps, and rubella combined (MMR) vaccines were discontinued in 1993 in Japan because of the unexpected high incidence of aseptic meningitis. The introduction of an effective MMR vaccine with lower reactogenicity has been expected. A new MMR vaccine (JVC-001) was developed, using mumps RIT4385 strain in combination with Japanese measles AIK-C strain and rubella Takahashi strain (MR) vaccine. Read More

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http://dx.doi.org/10.1080/21645515.2019.1578591DOI Listing
February 2019
6 Reads

Low anti-rubella antibody levels in public facilities staff in Tokyo.

Lancet Infect Dis 2019 Feb 30;19(2):132. Epub 2019 Jan 30.

The King Clinic, Tokyo 150-0001, Japan; Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30806-5DOI Listing
February 2019

Determination of rubella virus-specific humoral and cell-mediated immunity in pregnant women with negative or equivocal rubella-specific IgG in routine screening.

J Clin Virol 2019 Jan 24;112:27-33. Epub 2019 Jan 24.

Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), France; AP-HP, Hôpital Paul Brousse, Department of Virology, WHO Rubella NRL, 94804 Villejuif, France; Univ Paris-Sud, INSERM U1193, Villejuif, 94804 France. Electronic address:

Background: Immunity to rubella-virus (RV) is commonly determined by measuring specific IgG (RV-IgG). However, RV-IgG results may be different and even discordant, depending on the assay used. Cell-mediated immunity is not routinely investigated for diagnostic purposes. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.01.009DOI Listing
January 2019

Measles, mumps, and rubella: A cross-sectional study of susceptibility to vaccine-preventable diseases among young people in India.

Med J Armed Forces India 2019 Jan 18;75(1):70-73. Epub 2019 Jan 18.

Dean and Deputy Commandant, Armed Forces Medical College, Pune 411040, India.

Background: Global elimination of vaccine preventable diseases, such as measles, mumps and rubella is a priority. Many countries have reported diminishing of antibody titres against these diseases among young population as immunization coverage of adolescents and adults in not monitored. The objective of this study was to determine the susceptibility against measles, mumps and rubella among young adults. Read More

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http://dx.doi.org/10.1016/j.mjafi.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349678PMC
January 2019
1 Read

Declining prevalence of pediatric sudden deafness during the past two decades.

Int J Pediatr Otorhinolaryngol 2019 Jan 22;119:118-122. Epub 2019 Jan 22.

Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Objective: This study compared the prevalence of sudden deafness (SD) in children to investigate the evolution of pediatric SD during the past two decades.

Methods: From 1996 to 2005, totaling 358 SD patients were experienced. Of them, 25 patients (7%) aged <15 years were assigned to Group A. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.01.029DOI Listing
January 2019
1 Read

Validation of monoplex assays detecting antibodies against Corynebacterium diphtheriae and Clostridium tetani toxins, rubella virus and parvovirus B19 for incorporation into Multiplex Serology.

Methods 2019 Jan 28. Epub 2019 Jan 28.

Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. Electronic address:

Serological assays detecting antibodies in serum or plasma samples are useful and versatile instruments to investigate an individual's infection and vaccination history, e.g. for clinical diagnosis, personal risk evaluation, and seroepidemiological studies. Read More

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http://dx.doi.org/10.1016/j.ymeth.2019.01.013DOI Listing
January 2019
1 Read

Plasmonic gold chips for the diagnosis of Toxoplasma gondii, CMV, and rubella infections using saliva with serum detection precision.

Eur J Clin Microbiol Infect Dis 2019 Jan 30. Epub 2019 Jan 30.

Department of Chemistry, Stanford University, William Keck Science Building rm 125, Stanford, CA, 94305-5080, USA.

Sampling the blood compartment by an invasive procedure such as phlebotomy is the most common approach used for diagnostic purposes. However, phlebotomy has several drawbacks including pain, vasovagal reactions, and anxiety. Therefore, alternative approaches should be tested to minimize patient's discomfort. Read More

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http://dx.doi.org/10.1007/s10096-019-03487-1DOI Listing
January 2019
1 Read

School-based educational and on-site vaccination intervention among adolescents: study protocol of a cluster randomised controlled trial.

BMJ Open 2019 Jan 29;9(1):e025113. Epub 2019 Jan 29.

Medical Directorate, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Introduction: Childhood vaccination programmes have been established in all Organisation for Economic Co-operation and Development (OECD) countries; however, measles, mumps and rubella (MMR) as well as diphtheria, tetanus, pertussis and polio (Tdap-IPV) vaccination rates are not optimal in adolescents. Education in combination with easy access vaccination may be a promising approach to improve vaccination rates. We aim at improving MMR and Tdap-IPV rates in a school setting in the context of a planned cluster randomised controlled trial (cRCT), the present paper describes the detailed protocol of this trial. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025113DOI Listing
January 2019
1 Read

Simultaneous circulation of arboviruses and other congenital infections in pregnant women in Rio de Janeiro, Brazil.

Acta Trop 2019 Jan 24;192:49-54. Epub 2019 Jan 24.

Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, Brazil; Departamento de Patologia, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, Brazil. Electronic address:

Background: Arboviruses (Zika, dengue and chikungunya) represent a major risk for pregnant women, especially because their vertical transmission can lead to neurological damage in newborns. Early diagnosis can be difficult due to similar clinical presentation with other congenital infections that are associated with congenital abnormalities.

Objectives: To investigate the circulation of arboviruses and other pathogens responsible for congenital infections, reporting clinical aspects and geographic distribution of maternal rash in a metropolitan region of Rio de Janeiro (Brazil). Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.01.020DOI Listing
January 2019
3 Reads

50 Years Ago in The Journal of Pediatrics: Maternal and Congenital Rubella before 1964: Frequency, Clinical Features, and Search for Isoimmune Phenomena.

J Pediatr 2019 Feb;205:82

Department of Pediatrics University College of Medical Sciences Delhi, India.

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http://dx.doi.org/10.1016/j.jpeds.2018.08.045DOI Listing
February 2019
1 Read

Laboratory-based investigation of fever with rash cases in the Maharashtra State - India, 2014 to 2017.

J Med Virol 2019 Jan 24. Epub 2019 Jan 24.

Measles Group, ICMR-National Institute of Virology, Pune, Maharashtra, India.

The Maharashtra State (MS), India, launched measles surveillance in the year 2013. From 2014 to 2017, specimens from the patients presenting with fever and skin rashes were received at the National Institute of Virology, Pune. From 36 districts of the MS, 2795 cases (1428 males and 1367 females) were referred for the laboratory diagnosis of measles and rubella using immunoglobulin M enzyme immunoassay and/or RT-PCRs. Read More

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http://dx.doi.org/10.1002/jmv.25407DOI Listing
January 2019

Outcomes for Nitazoxanide Treatment in a Case Series of Patients with Primary Immunodeficiencies and Rubella Virus-Associated Granuloma.

J Clin Immunol 2019 Jan 24;39(1):112-117. Epub 2019 Jan 24.

Division of Allergy Immunology, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA.

Purpose: Nitazoxanide was recently reported as having in vitro effectiveness against the rubella virus. Immunodeficiency-related vaccine-derived rubella occurs in some patients who have an inherited immunodeficiency and who received the MMR vaccine. This study investigated the in vivo effectiveness of nitazoxanide therapy. Read More

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http://dx.doi.org/10.1007/s10875-019-0589-0DOI Listing
January 2019
2 Reads

Local and distal involution of recalcitrant warts after a single intralesional dose of measles, mumps, and rubella vaccine.

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

Naval Medical Center Camp Lejeune, Camp Lejeune, North Carolina.

Verruca vulgaris is a prevalent childhood condition, but treatments are often poorly tolerated. Early treatment is preferable because delays increase the probability of pain, disfigurement, and failed eradication. However, typical treatments require multiple sessions without promising cure. Read More

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December 2018
1 Read

Measles and rubella seroimmunity in newly arrived adult immigrants in Sweden.

Infect Dis (Lond) 2019 Jan 24:1-9. Epub 2019 Jan 24.

a Regional Office of Communicable Disease Control and Prevention, Region Skåne, Malmö, Sweden.

Background: International migrants could be considered as a risk group for being susceptible to vaccine preventable diseases such as measles and rubella. However, data on immunity in different migrant groups are scarce. Apart from asylum seekers and refugees, other immigrant groups might also be at risk. Read More

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http://dx.doi.org/10.1080/23744235.2018.1524583DOI Listing
January 2019
2 Reads

Relationship Between Media Coverage and Measles-Mumps-Rubella (MMR) Vaccination Uptake in Denmark: Retrospective Study.

JMIR Public Health Surveill 2019 Jan 23;5(1):e9544. Epub 2019 Jan 23.

Department of Computer Science, University of Copenhagen, Copenhagen, Denmark.

Background: Understanding the influence of media coverage upon vaccination activity is valuable when designing outreach campaigns to increase vaccination uptake.

Objective: To study the relationship between media coverage and vaccination activity of the measles-mumps-rubella (MMR) vaccine in Denmark.

Methods: We retrieved data on media coverage (1622 articles), vaccination activity (2 million individual registrations), and incidence of measles for the period 1997-2014. Read More

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http://dx.doi.org/10.2196/publichealth.9544DOI Listing
January 2019
1 Read

Mandatory vaccination of infants in France: Is that the way forward?

Eur J Gen Pract 2019 Jan 23:1-6. Epub 2019 Jan 23.

a Conseil Scientifique du Collège National des Généralistes Enseignants (CNGE) , Paris , France.

In this opinion paper, the authors argue that the extension of mandatory immunization of infants up to two years of age from three diseases (diphtheria, tetanus, poliomyelitis) to 11 diseases, introduced in France in January 2018, is not a sustainable response to the challenge of controlling vaccine-preventable diseases. In France in 2017, infant immunization coverage (IC) rates were sufficiently high or increasing (hepatitis B), except for measles, mumps and rubella (MMR) and meningococcus C disease. Even if vaccination obligation makes it possible to achieve the MMR IC objectives among infants, communication programmes and supported advice from GPs are essential for the catch-up of susceptible adults to obtain herd immunity. Read More

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http://dx.doi.org/10.1080/13814788.2018.1561849DOI Listing
January 2019
2 Reads

Seasonal influence on TORCH infection and analysis of multi-positive samples with indirect immunofluorescence assay.

J Clin Lab Anal 2019 Jan 21:e22828. Epub 2019 Jan 21.

Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Background: TORCH including the pathogens of Toxoplasma gondii (TOX), rubella virus (RV), cytomegalovirus (CMV), and herpes simplex virus (HSV) causes intrauterine infections and poses a worldwide threat to women especially in pregnancy. In this study, we described the seasonal difference in TORCH infection and analyzed the anti-TORCH IgM multipositive serum samples by the indirect immunofluorescence assays (IFA).

Methods: To observe the seasonal influence of the anti-TORCH IgG and IgM antibodies, a retrospective study was conducted with 10 669 women (20-40 y old) before pregnancy from August 2016 to July 2017. Read More

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http://doi.wiley.com/10.1002/jcla.22828
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http://dx.doi.org/10.1002/jcla.22828DOI Listing
January 2019
3 Reads

Intralesional Injection of the Measles-Mumps-Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial.

Iran J Med Sci 2019 Jan;44(1):10-17

General physician, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Common resistant-to-therapy warts pose a challenge to both clinicians and patients. Among many destructive and immunotherapeutic options, no single, fully effective treatment has been suggested yet. Many investigations, including those using intralesional antigen administrations, have demonstrated that cellular immunity plays a major role in the clearance of human papilloma virus (HPV) infection. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330524PMC
January 2019
5 Reads

Antiviral immunity in chronic lymphocytic leukemia measured by anti-rubella antibody.

Adv Clin Exp Med 2019 Jan 17. Epub 2019 Jan 17.

Department of Clinical Pharmacology, Wroclaw Medical University, Poland.

Background: Chronic lymphocytic leukemia (CLL), the most common form of adult leukemia in Caucasian populations, is characterized by a decrease in anti-infective immunity. Clinical evidence of antiviral immunity decrease is the reactivation of herpes virus in the form of skin lesions. In Europe, rubella infection is common and creates lifelong persistence of IgG antibodies. Read More

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http://dx.doi.org/10.17219/acem/94164DOI Listing
January 2019
2 Reads

Breastfeeding Prevalence at Time of Vaccination: Results of a Pilot Study in 6 Italian Regions.

J Hum Lact 2019 Jan 18:890334418823539. Epub 2019 Jan 18.

1 National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy.

Background: In Italy, there is no widespread standardized national monitoring system for breastfeeding practices.

Research Aims: To estimate breastfeeding indicators according to World Health Organization recommendations and associated socioeconomic factors, highlighting the potential and limitations of vaccination centers as sources of data.

Methods: A cross-sectional study was conducted in the vaccination centers of 13 Local Health Districts in Italy. Read More

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http://dx.doi.org/10.1177/0890334418823539DOI Listing
January 2019
3 Reads

Timeliness of routine immunization in non-preterm children less than 2 years old using electronic data capture in an ambulatory setting in France in the context of vaccine hesitancy.

Arch Pediatr 2019 Feb 10;26(2):56-64. Epub 2019 Jan 10.

Association française de pédiatrie ambulatoire (AFPA), 78100 Saint-Germain-en-Laye, France; Association Clinique et thérapeutique infantile du Val-de-Marne (ACTIV), 94100 Saint-Maur-des-Fossés, France; Service de néonatologie, unité Court Séjour, Petits Nourrissons, centre hospitalier Intercommunal de Créteil, 94010 Créteil France; Université Paris Est, IMRB-GRC GEMINI, 94010 Créteil, France. Electronic address:

Objectives: The vaccine schedule was changed in 2013 in France, which resulted in fewer vaccinations. However, to maintain disease protection, both vaccine timeliness and high coverage should be respected. In the context of growing vaccine hesitancy, we aimed to describe compliance with the immunization program according to the age recommended for each dose for non-preterm children less than 2 years old. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0929693X183025
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http://dx.doi.org/10.1016/j.arcped.2018.11.011DOI Listing
February 2019
8 Reads

Complications and risk factors for severe outcome in children with measles.

Arch Dis Child 2019 Jan 12. Epub 2019 Jan 12.

Pediatric Infectious Diseases Unit, Anna Meyer Children's University Hospital, Florence, Italy.

Objective And Design: Risk factors for severe measles are poorly investigated in high-income countries. The Italian Society for Paediatric Infectious Diseases conducted a retrospective study in children hospitalised for measles from January 2016 to August 2017 to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.

Results: Nineteen hospitals enrolled 249 children (median age 14. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315290DOI Listing
January 2019
2 Reads

T Lymphocytes as Measurable Targets of Protection and Vaccination Against Viral Disorders.

Int Rev Cell Mol Biol 2019 24;342:175-263. Epub 2018 Oct 24.

Department of Medicine, McGill University, Montréal, QC, Canada; Lady Davis Institute, Jewish General Hospital, Montréal, QC, Canada.

Continuous epidemiological surveillance of existing and emerging viruses and their associated disorders is gaining importance in light of their abilities to cause unpredictable outbreaks as a result of increased travel and vaccination choices by steadily growing and aging populations. Close surveillance of outbreaks and herd immunity are also at the forefront, even in industrialized countries, where previously eradicated viruses are now at risk of re-emergence due to instances of strain recombination, contractions in viral vector geographies, and from their potential use as agents of bioterrorism. There is a great need for the rational design of current and future vaccines targeting viruses, with a strong focus on vaccine targeting of adaptive immune effector memory T cells as the gold standard of immunity conferring long-lived protection against a wide variety of pathogens and malignancies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19376448183008
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http://dx.doi.org/10.1016/bs.ircmb.2018.07.006DOI Listing
October 2018
9 Reads

Case report on early treatment with valaciclovir after maternal primary cytomegalovirus infection.

J Gynecol Obstet Hum Reprod 2019 Jan 8. Epub 2019 Jan 8.

Service de Gynécologie-Obstétrique, Hôpital Antoine Béclère, Université Paris-Sud, Clamart, France. Electronic address:

Background: Cytomegalovirus (CMV) is the main cause of congenital viral infections. Current guidelines do not include any recommendation about antenatal treatment. Most studies that evaluate the efficacy of valaciclovir aim to treat infected symptomatic fetus but the benefit of anti-CMV therapy remains unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687847183041
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http://dx.doi.org/10.1016/j.jogoh.2019.01.003DOI Listing
January 2019
4 Reads

Zika Virus as a Possible Risk Factor for Autism Spectrum Disorder: Neuroimmunological Aspects.

Neuroimmunomodulation 2018 10;25(5-6):320-327. Epub 2019 Jan 10.

Department of Genetics, Institute of Biosciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre,

The recent outbreak of the Zika virus (ZIKV) and the discovery that perinatal Zika exposure can lead to the Congenital Zika Syndrome has promoted a call for prevention measures. Due to the increased number of babies born with microcephaly, structural brain abnormalities, and neurological alterations in regions affected by ZIKV, investigations were carried out in order to better understand this process. The maternal immune system directly influences the fetal central nervous system, and complications during pregnancy have been associated with neurodevelopmental disorders. Read More

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https://www.karger.com/Article/FullText/495660
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http://dx.doi.org/10.1159/000495660DOI Listing
January 2019
12 Reads

Measles, mumps, and rubella vaccine in genital warts: A case report of two patients.

Indian J Sex Transm Dis AIDS 2018 Jul-Dec;39(2):133-135

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Genital warts have a big psychological impact on the affected individuals, as the treatment requires time and multiple sessions at a time. They can also increase the chances of acquiring other sexually transmitted diseases. Various treatment options are available including the topical application of imiquimod, podophyllin, trichloroacetic acid application, cryotherapy, and radiofrequency cautery. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_44_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298159PMC
January 2019
1 Read

Risk factors associated with accelerated rubella-IgG antibody loss in previously vaccinated,treatment-naïve juvenile Systemic Lupus Erythematosus patients: a prospective study.

Arthritis Rheumatol 2019 Jan 5. Epub 2019 Jan 5.

Infectious Diseases Unit, Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, Medical School, National and Kapodistrian University of Athens, Greece.

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease primarily affecting young females. SLE patients are susceptible to infections due to their defective immune system and the immunosuppressive treatment they receive[1]. However we lack data regarding response to specific vaccines. Read More

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http://doi.wiley.com/10.1002/art.40831
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http://dx.doi.org/10.1002/art.40831DOI Listing
January 2019
6 Reads

Rubella Virus-Associated Cutaneous Granulomatous Disease: a Unique Complication in Immune-Deficient Patients, Not Limited to DNA Repair Disorders.

J Clin Immunol 2019 Jan 3;39(1):81-89. Epub 2019 Jan 3.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Department of Pediatrics, University of Washington, Seattle, WA, USA.

The association of immunodeficiency-related vaccine-derived rubella virus (iVDRV) with cutaneous and visceral granulomatous disease has been reported in patients with primary immunodeficiency disorders (PIDs). The majority of these PID patients with rubella-positive granulomas had DNA repair disorders. To support this line of inquiry, we provide additional descriptive data on seven previously reported patients with Nijmegen breakage syndrome (NBS) (n = 3) and ataxia telangiectasia (AT) (n = 4) as well as eight previously unreported patients with iVDRV-induced cutaneous granulomas and DNA repair disorders including NBS (n = 1), AT (n = 5), DNA ligase 4 deficiency (n = 1), and Artemis deficiency (n = 1). Read More

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http://link.springer.com/10.1007/s10875-018-0581-0
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http://dx.doi.org/10.1007/s10875-018-0581-0DOI Listing
January 2019
6 Reads

Spontaneous Lens Absorption Initially Misdiagnosed as Crystalline Lens Luxation

Turk J Ophthalmol 2018 Dec;48(6):320-322

Selçuk University Faculty of Medicine, Department of Ophtalmology, Konya, Turkey

Spontaneous lens absorption (SLA) is a rare complication of hypermature cataract. However, this condition has been reported in several cases of hypermature cataracts that were caused by trauma, senility, uveitic disorders such as Fuchs’ uveitis syndrome (FUS), and infectious disorders including leptospirosis and rubella. We report a case of spontaneous absorption of a hypermature cataract secondary to FUS. Read More

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http://dx.doi.org/10.4274/tjo.65725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330671PMC
December 2018
2 Reads

Talk to Patients About: Rubella.

Authors:
Sean Price

Tex Med 2018 Dec 1;114(12):47. Epub 2018 Dec 1.

The virus that causes rubella often appears deceptively mild - so mild in fact that one-quarter to half of people infected with it will have no symptoms at all, according to the Centers for Disease Control and Prevention (CDC). Vaccination is the best protection. Read More

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December 2018

Revaccination in Children Undergoing Autologous Hematopoietic Stem Cell Transplantation: Results of a Survey in Germany, Austria and Switzerland.

Klin Padiatr 2019 Jan 2. Epub 2019 Jan 2.

Pediatric Hematology and Oncology, University of Frankfurt, Frankfurt, Germany.

Background: Due to the potential loss of protective antibody titers after autologous hematopoietic stem cell transplantation (HSCT), revaccination is important. The aim of the study was to evaluate the current strategies in Germany, Austria and Switzerland for revaccination of children after autologous HSCT.

Methods: An internet-based survey was performed, and results were analyzed in a descriptive way. Read More

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http://dx.doi.org/10.1055/a-0796-6719DOI Listing
January 2019
1 Read

Association of Ocular Inflammation and Rubella Virus Persistence.

JAMA Ophthalmol 2018 Dec 27. Epub 2018 Dec 27.

Francis I. Proctor Foundation, University of California, San Francisco.

Importance: Metagenomic deep sequencing (MDS) demonstrates that persistent and active rubella virus (RV) infection is associated with Fuchs heterochromic iridocyclitis (FHI).

Objective: To assess the utility of MDS in identifying RV infection in patients with uveitis.

Design, Setting, And Participants: This case series assessed 6 patients diagnosed by MDS with RV-associated uveitis at a tertiary uveitis referral center in the United States. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.6185DOI Listing
December 2018
1 Read

Current perspectives in assessing humoral immunity after measles vaccination.

Expert Rev Vaccines 2019 Jan 26;18(1):75-87. Epub 2018 Dec 26.

a Mayo Clinic Vaccine Research Group , Mayo Clinic , Rochester , MN , USA.

Introduction: Repeated measles outbreaks in countries with relatively high vaccine coverage are mainly due to failure to vaccinate and importation; however, cases in immunized individuals exist raising questions about suboptimal measles vaccine-induced humoral immunity and/or waning immunity in a low measles-exposure environment. Areas covered: The plaque reduction neutralization measurement of functional measles-specific antibodies correlates with protection is the gold standard in measles serology, but it does not assess cellular-immune or other parameters that may be associated with durable and/or protective immunity after vaccination. Additional correlates of protection and long-term immunity and new determinants/signatures of vaccine responsiveness such as specific CD46 and IFI44L genetic variants associated with neutralizing antibody titers after measles vaccination are under investigation. Read More

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https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
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http://dx.doi.org/10.1080/14760584.2019.1559063DOI Listing
January 2019
9 Reads

Travel medicine consultation: An opportunity to improve coverage for routine vaccinations.

Med Mal Infect 2018 Dec 21. Epub 2018 Dec 21.

Service des maladies infectieuses et tropicales, Centre de vaccinations internationales et conseils aux voyageurs, CHU de Saint-Étienne, 42055 Saint-Étienne, France; Inserm, CIC 1408, 42055 Saint-Étienne, France; Inserm, F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), 75679 Paris, France; Groupe immunité des muqueuses et agents Pathogènes - GIMAP EA 3064, université de Saint-Étienne, Université de Lyon, 42270 Saint-Priest-en-Jarez, France.

Background: Travelers may be responsible for the spread of vaccine-preventable diseases upon return. Travel physicians and family physicians may play a role in checking and updating vaccinations before traveling. Our aim was to evaluate the vaccine coverage for mandatory and recommended vaccination in travelers attending a travel medicine clinic (TMC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0399077X173085
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http://dx.doi.org/10.1016/j.medmal.2018.11.008DOI Listing
December 2018
7 Reads

Using protection motivation theory to predict intention to adhere to official MMR vaccination recommendations in Switzerland.

SSM Popul Health 2019 Apr 15;7:005-5. Epub 2018 Nov 15.

Institute of Communication and Health, Università della Svizzera italiana, Switzerland.

Switzerland has not yet reached the measles vaccination coverage of 95 percent that is recommended by the World Health Organization to achieve herd immunity. Within the overall objective of informing effective ways to promote the combined Measles, Mumps, Rubella (MMR) vaccination in Switzerland, the aim of this study was to identify predictors of parents' intention to adhere to official MMR vaccination recommendations. Between October 2012 and January 2013, we surveyed 554 parents of middle school students aged 13 to 15 in Ticino, Switzerland. Read More

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http://dx.doi.org/10.1016/j.ssmph.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293080PMC
April 2019
1 Read

Rubella Retinopathy.

Adv Exp Med Biol 2018 ;1085:215-217

Department of Ophthalmology, Columbia University, Edward S. Harkness Eye Institute, NewYork-Presbyterian Hospital, New York, NY, USA.

Definition: A phenocopy is an individual showing features (phenotype) characteristic of a genotype but produced environmentally rather than genetically (not inherited); these features are not due to mutations, as the underlying DNA sequence of the phenocopy is not altered. Read More

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http://link.springer.com/10.1007/978-3-319-95046-4_45
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http://dx.doi.org/10.1007/978-3-319-95046-4_45DOI Listing
January 2018
7 Reads

The value of tailoring vial sizes to populations and locations.

Vaccine 2019 Jan 19;37(4):637-644. Epub 2018 Dec 19.

HERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA; HERMES Logistics Modeling Team, Pittsburgh, PA, USA; Global Obesity Prevention Center (GOPC) at Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA; Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA. Electronic address:

Background: Frequently, a country will procure a single vaccine vial size, but the question remains whether tailoring the use of different size vaccine vial presentations based on populations or location characteristics within a single country could provide additional benefits, such as reducing open vial wastage (OVW) or reducing missed vaccination opportunities.

Methods: Using the Highly Extensible Resource for Modeling Supply Chains (HERMES) software, we built a simulation model of the Zambia routine vaccine supply chain. At baseline, we distributed 10-dose Measles-Rubella (MR) vials to all locations, and then distributed 5-dose and 1-dose MR vials to (1) all locations, (2) rural districts, (3) rural health facilities, (4) outreach sites, and (5) locations with average MR session sizes <5 and <10 children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183165
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http://dx.doi.org/10.1016/j.vaccine.2018.12.010DOI Listing
January 2019
9 Reads